Autoimmune Hemolytic Anemia as Presenting Manifestation of Multiple Myeloma
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - January 11, 2020 Category: Hematology Source Type: research

Rifampin Induced Thrombotic Thrombocytopenic Purpura
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - January 10, 2020 Category: Hematology Source Type: research

HLH Masquerading Lymphoma: Diagnostic Dilemma and Treatment Outcomes
AbstractA case series to illustrate difficulties faced in diagnosis, management and subsequent therapeutic approach patients presenting with HLH secondary to lymphoma. A retrospective review of patients treated for HLH and lymphoma in Clinical Hematology department of a tertiary care hospital in North India, was performed from Jan 2017 to April 2019. Follow up was included till September 2019. Diagnosis of HLH was made using HLH 2004 criteria along with H score. Only patients who fulfilled HLH 2004 criteria were included. Nine patients were treated during above period, three patients with Hodgkins lymphoma, two patients ha...
Source: Indian Journal of Hematology and Blood Transfusion - January 9, 2020 Category: Hematology Source Type: research

Double Hit and Double Expresser Diffuse Large B Cell Lymphoma Subtypes: Discrete Subtypes and Major Predictors of Overall Survival
AbstractDouble hit lymphomas (DHL) and double expresser lymphomas (DEL) are subsets of diffuse large B cell lymphomas (DLBCL) which are being increasingly recognised as cause of treatment failure. This emphasizes the need for their separation from other DLBCL cases in order to prognosticate and administer more aggressive treatment to this set of patients. The present study was conducted with the aim to identify the DHL/DEL patients and study their distinctive clinicopathological profile and overall survival. This retrospective analysis involved 172 cases of DLBCL sub-classified on the basis of cell of origin. Immunohistoch...
Source: Indian Journal of Hematology and Blood Transfusion - January 8, 2020 Category: Hematology Source Type: research

Thrombopoiesis: At a Glance !
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - January 8, 2020 Category: Hematology Source Type: research

Assessment of Knowledge and Practice of Blood Transfusion Among Nurses in a Tertiary Care Hospital in India
The objective was to make use of the results to decide the necessity of targeted teaching using lectures and simulated ward scenes. This was a cross sectional study in which a questionnaire comprising of 25 single best-response type multiple choice questions related to blood products and blood transfusion was distributed to nurses who were selected randomly. Questions were both knowledge and practice based. Five hundred and forty-six nurses consented and were assessed. The data was collected, entered and statistically assessed. The number of ‘Correct’, ‘Incorrect’ and ‘Don’t Know’ ...
Source: Indian Journal of Hematology and Blood Transfusion - January 4, 2020 Category: Hematology Source Type: research

Algorithm to Study HLA-Antibodies and Selecting Criteria for the Best Haploidentical Donor
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - January 3, 2020 Category: Hematology Source Type: research

Adverse effects with intravenous methotrexate in children with acute lymphoblastic leukemia/lymphoma: a retrospective study
AbstractMethotrexate (MTX) forms the backbone of maintenance cycles in childhood acute lymphoblastic leukemia (ALL) chemotherapy, including interim maintenance. There is sufficient published data describing toxicities of high dose MTX  (HD-MTX), but toxicities with escalating doses of MTX (Capizzi regimen) is not well documented. Capizzi regimen is thought to be relatively safe; we contend that even low escalating doses of MTX have significant toxicities. Our study intends to characterise such events with Capizzi MTX in comparis on to that seen with HD-MTX. The retrospective study was conducted at a tertiary...
Source: Indian Journal of Hematology and Blood Transfusion - January 2, 2020 Category: Hematology Source Type: research

Hematoidin Pigment with Bone Marrow Necrosis in Sickle Cell Anemia
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - January 2, 2020 Category: Hematology Source Type: research

Higher Level of Peripheral Blood CD34 Positive Cells Presented with Unfavorable Prognosis in Intermediate-Low Risk Acute Promyelocytic Leukemia
In this study, 76 intermediate-low risk APL patients and 56 age-adjusted healthy volunteers were evaluated. Enumeration of CD34+ cells was inves tigated before the treatment. A cut-off value of 10 × 106/L CD34+ cells could just distinguish APL patients with adverse prognostic factors from others and may have the power to predict shorter progression-free survival (PFS) and poor prognosis. Higher count of CD34+ cells was usually associated with nonclassical chromosomal translocation, PML/RAR α gene complex fusion, APL history, chemotherapy-related APL, disease progression, second tumor, extramedulla...
Source: Indian Journal of Hematology and Blood Transfusion - December 17, 2019 Category: Hematology Source Type: research

Somatic Hemizygous Y371H CBL Mutation with Loss of Heterozygosity Presenting with BENTA Type Lymphoid Proliferation
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - December 16, 2019 Category: Hematology Source Type: research

Risk Stratification in Multiple Myeloma in Indian Settings
AbstractMultiple myeloma (MM) constitutes 10% of all hematological malignancies. The last one decade has seen a phenomenal progress in the therapeutic options available for the management. Although it still remains incurable, with the advent of newer therapies, the median survival in many risk groups is now around 10  years. Conventional karyotyping of bone marrow samples has a positivity rate of 20–30% at diagnosis in patients of Multiple Myeloma. However, array Comparative Genomic Hybridisation (aCGH) has revealed that almost all MM patients have cytogenetic abnormalities which may affect the pathophysiolog y,...
Source: Indian Journal of Hematology and Blood Transfusion - December 14, 2019 Category: Hematology Source Type: research

Acute Coronary Syndrome Associated with Carfilzomib Treatment
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - December 13, 2019 Category: Hematology Source Type: research

MicroRNA 30a Mediated Autophagy and Imatinib Response in Egyptian Chronic Myeloid Leukemia Patients
AbstractImatinib Mesylate is the drug used for targeted tyrosine kinase inhibition in the beginning of management of all Chronic Myeloid Leukemia (CML) newly diagnosed cases. However, resistance presents a considerable limit to its efficacy. Currently, it is impossible to anticipate IM resistance which makes the recognition of early flags an important treatment goal in CML. In this work we studied the connection between microRNA 30a (miR-30a) and Beclin 1 mediated autophagy and IM resistance in Egyptian CML patients. The study included newly diagnosed (group I, n  = 20), imatinib responder (group II, n&thinsp...
Source: Indian Journal of Hematology and Blood Transfusion - December 12, 2019 Category: Hematology Source Type: research

Coexistence of Serum Monoclonal Gammopathy of Uncertain Significance and Hodgkin Lymphoma
AbstractAn uncommon association between multiple myeloma and Hodgkin lymphoma (HL) was observed in some case reports, while an association with monoclonal gammopathy of uncertain significance (MGUS) is exceedingly rare. We have diagnosed 110 HL cases from 2008 to 2018; here we report 4 HL cases associated with MGUS. MGUS was diagnosed before HL (1 case), together with HL (1 case) or after HL (2 cases). M-component was IgG/k (3 cases) and IgG/k and IgG/ λ (1 case), MGUS was not influenced by HL treatment (2 cases), raised after therapy (1 case), while in the last case MGUS appeared after ASCT while HL was in complete...
Source: Indian Journal of Hematology and Blood Transfusion - December 12, 2019 Category: Hematology Source Type: research

Paratrabecular myelofibrosis and occult mastocytosis are strong morphological clues to suspect FIP1L1-PDGFRA translocation in hypereosinophilia
AbstractTo study the clinico-haematological and histopathological characteristics ofFIP1L1-PDGFRA rearranged hypereosinophilia/hypereosinophilic syndrome (F/P+ve HE/HES), a retrospective analysis of patients with F/P+ve HE diagnosed over a period of 43  months was performed. Peripheral blood smears, bone marrow aspirate (BMA) and biopsies (BMB) were reviewed in each case and; reticulin stain and immunohistochemistry for mast cell tryptase (MCT) and CD117 was performed. F/P+ve HE was diagnosed in a total of ten patients during study period. All pa tients were males with a median age of 36 years (23–44 y...
Source: Indian Journal of Hematology and Blood Transfusion - December 4, 2019 Category: Hematology Source Type: research

Efficacy of Dichlorophenolindophenol (DCIP) as Screening Test for Hb E: Revisited
AbstractHb E-beta thalassemia is a major public health problem in West Bengal, India and is the predominant symptom producing thalassemia in this part of the country. To search for an easy, reliable and cost effective screening method for HbE that can be used at the community level where more sophisticated methods are not readily available. And the DCIP test was performed for the purpose. Blood samples of 425 asymptomatic family members from 80 diagnosed cases of HbE beta Thalassemia patients were tested for Hb, RBC indices, DCIP test, HPLC, and in discordant cases confirmed by DNA mutation analysis. The present study show...
Source: Indian Journal of Hematology and Blood Transfusion - December 4, 2019 Category: Hematology Source Type: research

Skeletal Lesions and Adductor Compartment Mass: A Rare Presentation of Hairy Cell Leukemia
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - December 2, 2019 Category: Hematology Source Type: research

Nasal-Type Extranodal Natural Killer/T Cell Lymphoma with Meningeal Involvement: A Case Report and Literature Review
ConclusionMeningeal metastasis of ENKTL is rare; when patients present with nervous system symptoms, CNS metastasis should be considered as a possibility, even in the early stage. The OS of our patient was 15  months, which is the longest survival time reported in the literature, probably due to early diagnosis and comprehensive management, including intrathecal therapy, chemotherapy and radiotherapy of the whole brain and spinal cord. (Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - November 30, 2019 Category: Hematology Source Type: research

Markers of Thrombin Generation and Inflammation in Patients with Paroxysmal Nocturnal Hemoglobinuria
In this study we describe disease burden and risk factors for thrombosis in 18 Indian PNH patients. We studied markers of thrombin generation (Thrombin-antithrombin complexes; TAT and D-Dimer), endothelium and platelet activation (soluble P-selectin) and inflammation (interleukin-6; IL-6) in PNH patients and compared their levels with healthy controls. Thrombosis was identified in 17% of PNH patients. TAT, sP-selectin and D-Dimer levels were significantly elevated in PNH patients (TAT: 5.06  ± 1.08 ng/ml; sP-selectin: 80.57 ± 19.5 ng/ml; D-Dimer mean: 936 ng/ml 95% C...
Source: Indian Journal of Hematology and Blood Transfusion - November 26, 2019 Category: Hematology Source Type: research

Inherited Bleeding Disorders in North Indian Children: 14  years’ Experience from a Tertiary Care Center
AbstractInherited bleeding disorders are not uncommon in pediatric practice: most of them being chronic, require lifelong replacement therapy. To frame a management policy, it is essential to assess the load and pattern of bleeding disorders in the local population. However, there is paucity of data reporting the clinical spectrum of coagulation and platelet function disorders in Indian children. Hence to find out the exact burden and clinico-investigational profile of these patients we conducted this study. In this retrospective case review, detailed clinical information was extracted from case records in 426 children wit...
Source: Indian Journal of Hematology and Blood Transfusion - November 21, 2019 Category: Hematology Source Type: research

Promising Response to Thalidomide in Symptomatic β-Thalassemia
AbstractOver the past decade, few reports suggested that the drug thalidomide (HbF inducer) may be of value in a subset of transfusion-dependent and non-transfusion dependent thalassemia patients. A cohort of 37 patients with symptomatic β-thalassemia syndrome [14 transfusions dependent thalassemia (TDT), and 23 Non-transfusion dependent Thalassemia (NTDT)], who were unable to pursue conventional therapy with transfusion and chelation, were recruited over 3 years in a center in Iraqi Kurdistan. After taking informed consent, patien ts were put on low dose Thalidomide (2–10 mg/kg), with regular follow up aft...
Source: Indian Journal of Hematology and Blood Transfusion - November 18, 2019 Category: Hematology Source Type: research

Spontaneus Triplet Birth After Acute Lymphoblastic Leukemia Treatment
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - November 18, 2019 Category: Hematology Source Type: research

Forecasting the Amount of Blood Ordered in the Obstetrics and Gynaecology Ward with the Data Mining Approach
AbstractPreoperative blood ordering is frequently used in the obstetrics and gynecology ward of university hospitals in Iran, even for surgeries that rarely require blood transfusions. This routine procedure is an inefficient use of resources and rising costs, wasting time and cause shortage for essential patients. So this study was carried out to propose a new optimal system based on data mining techniques for ordering blood. This cross-sectional study examined the number of units cross-matched and transfused during surgery in the obstetrics and gynecology ward from 2013 to 2015. Data was collected for 1097 patients. Stat...
Source: Indian Journal of Hematology and Blood Transfusion - November 14, 2019 Category: Hematology Source Type: research

14 –3–3ζ Regulates the Platelet Apoptosis During Storage
AbstractThere is an increasing interest in the possibility of storing platelet concentrates below standard temperatures. The role of 14 –3–3 proteins has been demonstrated in numerous cellular functions, including both its positive and negative roles in apoptosis. The 14–3–3ζ protein has a potential role in regulation of storage induced apoptosis in platelets. Apheresis platelets were collected and stored under either at ro om temperature (RT, 20–24 °C) or cold temperature (CT, 2–6 °C) conditions (n = 7 in each group). Flow cytometry was used to asses...
Source: Indian Journal of Hematology and Blood Transfusion - November 14, 2019 Category: Hematology Source Type: research

Flow Cytometry Based MRD and Its Impact on Survival Outcome in Children and Young Adults with ALL: A Prospective Study from a Tertiary Cancer Centre in Southern India
AbstractPresence of minimal residual disease (MRD) following induction chemotherapy is a well-recognized risk factor to predict relapse in acute lymphoblastic leukemia (ALL). There is paucity of data on MRD and outcome in ALL from India. We share our experience in establishing a flow cytometry-based MRD assay for ALL with emphasis on determination of the number of patients who had MRD on day 35 of induction therapy and its correlation with outcome and other prognostic factors. We prospectively studied MRD in patients with ALL less than 25  years who achieved morphological complete remission with induction therapy. The...
Source: Indian Journal of Hematology and Blood Transfusion - November 9, 2019 Category: Hematology Source Type: research

FLAER Based Assay According to Newer Guidelines Increases Sensitivity of PNH Clone Detection
In this study, the abnormal PNH clones were detected using a single tube FLAER based testing and two tubes non-FLAER based testing in all cases of PNH (n = 12), healthy subjects (n = 18) and AA/MDS with PNH clone (n = 9) and compared with clinical and laboratory features at di agnosis. The receiver operator curve (ROC) analysis defined the optimal cut-offs for FLAER in granulocytes (>  0.7%) and monocytes (>  0.9%). There was significant positive correlation between FLAER and non-FLAER based testing in these cells (r >  0.3 andp 
Source: Indian Journal of Hematology and Blood Transfusion - November 5, 2019 Category: Hematology Source Type: research

Experience of Immune Tolerance Induction Therapy for Hemophilia A Patients with Inhibitors from a Single Center in India
AbstractThe availability of clotting factor concentrates of both factor VIII and factor IX have improved  hemophilia treatment to a great extent. Many more improvements like physiotherapy, and comprehensive care are needed to give better care. One important complication that occurs, but is often set aside is the development of inhibitors. When an inhibitor develops in a patient of severe hemophilia t hen the care becomes more difficult and expensive. Eradication of the inhibitor is possible by Immune tolerance induction (ITI), this paper explains some important essential factors and practical issues during my exp...
Source: Indian Journal of Hematology and Blood Transfusion - November 4, 2019 Category: Hematology Source Type: research

Expression Pattern and Prognostic Significance of EVI1 Gene in Adult Acute Myeloid Leukemia Patients with Normal Karyotype
AbstractAccording to current criteria, patients with acute myeloid leukemia with normal karyotype (AML-NK) are classified as intermediate risk patients. There is a constant need for additional molecular markers that will help in substratification into more precise prognostic groups. One of the potential new markers is Ecotropic viral integration 1 site (EVI1) transcriptional factor, whose expression is dissregulated in abnormal hematopoietic process. The purpose of this study was to examineEVI1 gene expression in 104 adult AML-NK patients and on 10 healthy bone marrow donors using real-time polymerase chain reaction method...
Source: Indian Journal of Hematology and Blood Transfusion - November 4, 2019 Category: Hematology Source Type: research

The Characteristics of AIHA Patients Benefited from Glucocorticoid Treatment
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - October 28, 2019 Category: Hematology Source Type: research

Primary Cardiac Lymphoma
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - October 28, 2019 Category: Hematology Source Type: research

Systemic Mastocytosis with Associated Primary Myelofibrosis
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - October 28, 2019 Category: Hematology Source Type: research

60th Annual Conference of Indian Society of Hematology & amp; Blood Transfusion (ISHBT) October 2019
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - October 26, 2019 Category: Hematology Source Type: research

Cannibalistic Hemophagocytosis in Acute Myeloid Leukemia with Trisomy 9
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - October 26, 2019 Category: Hematology Source Type: research

Erythrophagocytosis by Neutrophil and Monocyte in Autoimmune Hemolytic Anemia After Infection
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - October 26, 2019 Category: Hematology Source Type: research

Conventional Cytogenetics and Interphase Fluorescence In Situ Hybridization Results in Multiple Myeloma: A Turkey Laboratory Analysis of 381 Cases
AbstractMultiple myeloma (MM) is an uncontrolled proliferation of plasma cells and these cells play an important role in the immune system. In this research, we retrospectively analyzed cytogenetic abnormalities in 381 patients with MM. Conventional cytogenetic analysis was successful in 354 patients (92.9%). Chromosomal abnormalities were detected in 31.9% (113/354) and 45.8% (116/253) of patients screened with conventional cytogenetics and FISH, respectively. Of 113 patients with chromosomal abnormalities, 31 patients (27.4%) had hyperdiploid and 26 of 31 patients with hyperdiploidy had both numerical and structural anom...
Source: Indian Journal of Hematology and Blood Transfusion - October 25, 2019 Category: Hematology Source Type: research

Aplastic Crisis in a Woman with Autoimmune Hemolytic Anemia
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - October 25, 2019 Category: Hematology Source Type: research

A Prospective, Cross Sectional Study of PNH Clone in MDS Patients Using High Sensitivity Flowcytometry: A Single Center Experience
AbstractSubclinical PNH can be present in patients with bone marrow failure like aplastic anemia and myelodysplastic syndrome (MDS). Such clone may have prognostic and therapeutic implications. In literature around 1 –10% MDS cases have shown a PNH clone, however, data from India is relatively scarce. A high sensitivity PNH assay was employed using a single tube combination of FLAER, CD157, CD64, CD15 and CD45 antibodies in adult patients of MDS at presentation. A clone size of  >  0.01% was taken as significant. A total of 30 patients were included. PNH clone was present in 30% cases. Correlati...
Source: Indian Journal of Hematology and Blood Transfusion - October 24, 2019 Category: Hematology Source Type: research

Activity Wise Unit Cost of Blood Components in a Tertiary Care Hospital Blood Bank for the Year 2018
AbstractThe present study on cost of a unit of blood was conducted in blood bank of a tertiary care public hospital with an annual collection of 20,748. A retrospective chart review was done to calculate the activity wise annual unit cost of blood, based on WHO guidelines (Blood Safety Unit. safe blood and blood products: costing blood transfusion services, World Health Organization, Geneva, 1998). Cost of blood collection, processing and storage were included. Annualized economic cost of equipments, maintenance, personnel salaries, and consumables were enlisted. It was assumed that all component units prepared carried equ...
Source: Indian Journal of Hematology and Blood Transfusion - October 22, 2019 Category: Hematology Source Type: research

Re-defining Prognosis of Hematological Malignancies by Dynamic Response Assessment Methods: Lessons Learnt in Chronic Myeloid Leukemia, Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma and Multiple Myeloma
AbstractRisk-stratification is an essential management tool in defining prognosis of haematological neoplasms, both from patient and physician perspective. We define a new prognostic term “Dynamic Response Assessment Method(s) (DRAM)” as “method(s) used for re-stratifying disease prognosis at fixed intervals during the treatment course”. The risk stratification is done after a fixed duration of treatment or chemotherapy cycles using sensitive techniques. The information obtai ned then can be used for further therapeutic decisions and prognostication. Currently, there is enough evidence that response...
Source: Indian Journal of Hematology and Blood Transfusion - October 22, 2019 Category: Hematology Source Type: research

The IJHBT Editorial Board ’s Journey (2013–2019)
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - October 22, 2019 Category: Hematology Source Type: research

An Editor-in-Chief ’s Reminiscences
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - October 19, 2019 Category: Hematology Source Type: research

Endocrine Challenges and Metabolic Profile in Recipients of Allogeneic Haematopoietic Stem Cell Transplant: A Cross-Sectional Study from Southern India
AbstractAlthough haematopoietic stem cell transplant has been successfully employed in the cure of several malignant and non-malignant conditions, survivors often suffer from delayed effects involving the endocrine system and cardio-metabolic risk factors. In this cross-sectional study, we aimed to assess the prevalence of endocrine dysfunction and alterations in metabolic profile in 63 recipients of allogeneic stem cell transplantation as compared to 65 age, sex and body mass index matched controls. Hypogonadism emerged as the most prevalent endocrinopathy, present in 23/60 (38.3%) of subjects, followed by overt and subcl...
Source: Indian Journal of Hematology and Blood Transfusion - October 16, 2019 Category: Hematology Source Type: research

Molecular Characterization of G6PD Deficiency: Report of Three Novel G6PD Variants
AbstractG6PD deficiency is a monogenic, X-linked genetic defect with a worldwide prevalence of around 400 million people and an overall prevalence of 8.5% in India. Hemolytic anemia is encountered in only a small proportion of patients with G6PD variants and is usually triggered by some exogenous agent. Although G6PD deficiency was reported in India more than 50  years ago, there are very few studies on molecular characterization and phenotypic correlation in G6PD deficient patients. We aimed to study the epidemiology and correlate the phenotypic expression with molecular genotypes in symptomatic G6PD deficient patien...
Source: Indian Journal of Hematology and Blood Transfusion - October 16, 2019 Category: Hematology Source Type: research

Deregulated Expression of Long Non-coding RNA HOX Transcript Antisense RNA (HOTAIR) in Egyptian Patients with Multiple Myeloma
AbstractIncreasing evidence of involvement of non-coding RNAs, especially long non-coding RNAs (lncRNAs), in the molecular biology of various malignancies have been recently reported. Their utilization as markers for diagnosis, prognosis and evaluation of treatment response was widely investigated. As the impact of lncRNA HOTAIR on multiple myeloma (MM) was not properly highlighted, we aimed to explore the expression levels of HOTAIR in three groups of MM patients and to analyze its relationship to different patients ’ characteristics. Plasma samples were withdrawn from 24 newly diagnosed MM patients, 23 post-therapy...
Source: Indian Journal of Hematology and Blood Transfusion - October 16, 2019 Category: Hematology Source Type: research

The Expression of P53, MDM2, c-myc, and P14 ARF Genes in Newly Diagnosed Acute Lymphoblastic Leukemia Patients
This study aimed to investigate the expression of these genes, also their correlation with immunophenotypic subtypes of ALL and the percentage of blasts. Real-time PCR was performed for the expression analysis of P53, MDM2, c-MYC, and P14ARF in the bone marrow or peripheral blood samples of 52 ALL patients and 13 normal samples as controls. The morphological analysis and flow cytometry were carried out to examine the phenotypes and percentage of lymphoblasts. The decreased expression levels of P53 and MDM2 were seen in ALL patients compared with control group. In T cell subgroup of ALL the expression of P14ARF gene was mor...
Source: Indian Journal of Hematology and Blood Transfusion - October 16, 2019 Category: Hematology Source Type: research

All That Lights-Up is not Lymphoma
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - October 14, 2019 Category: Hematology Source Type: research

CRAB Positive Acute Lymphoblastic Leukemia, Masquerader of Multiple Myeloma
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - October 10, 2019 Category: Hematology Source Type: research

Approach to the Diagnosis of Amyloidosis
AbstractAmyloidosis is heterogeneous group of disorder characterized by extracellular deposition of misfolded insoluble proteinaceous material with cross beta pleated sheet structure leading to organ dysfunction. This disease is rare and indeed heterogeneous, as it may be hereditary (familial amyloidosis), secondary to spectrum of inflammatory conditions (AA amyloidosis) or member of plasma cell neoplasm family (AL amyloidosis). AL amyloidosis is the most common type of amyloid, however, is rarely accompanied by multiple myeloma or other lymphoproliferative disorder. This disparity in its origin and presentation needs to b...
Source: Indian Journal of Hematology and Blood Transfusion - October 9, 2019 Category: Hematology Source Type: research

Impact of World Health Organization (WHO) Revised Criteria-2016 on the Diagnosis of Polycythemia Vera
AbstractThe diagnosis of polycythemia vera (PV) requires the integration of clinical and laboratory findings, bone marrow morphologic features, and JAK2 analysis. JAK2V617F (exon 14) mutation is found in 95% of PV cases. In PV, addition of characteristic bone marrow morphology as one of three major diagnostic criteria allowed reduced hemoglobin/hematocrit threshold for diagnosis to 16.5  g/dL/49% in men and 16 g/dL/48% in women. JAK2 mutation is still the third major diagnostic criterion in PV. Low serum erythropoietin level is now considered as minor criterion in PV and is used to detect cases, which are negativ...
Source: Indian Journal of Hematology and Blood Transfusion - October 9, 2019 Category: Hematology Source Type: research