Indian Journal of Hematology and Blood Transfusion This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Post Covid-19 Reactive Arthritis in Two Stem Cell Transplant Recipients
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - July 13, 2022 Category: Hematology Source Type: research

Role of MicroRNA-326 and its Target Genes Bcl-xL and Bak as Potential Markers in Platelet Storage Lesion in Blood Banks
AbstractPlatelet transfusion is crucial in the management of various conditions such as quantitative and qualitative platelet disorders. A serious problem that impacts public health is the shortage of Platelet concentrates (PCs) that frequently affect few blood donors ’ countries, such as Egypt. This has necessitated the need to establish novel standards for determining the quality of PC during storage. It was found that microRNAs (miRNA) differential expression profile is a helpful tool for recognition of physiological platelet changes during storage. The aim of the current study was to highlight the role of platelet mi...
Source: Indian Journal of Hematology and Blood Transfusion - June 2, 2022 Category: Hematology Source Type: research

Twist1 Promoter Methylation Regulates the Proliferation and Apoptosis of Acute Myeloid Leukemia Cells via PI3K/AKT Pathway
AbstractTwist-related protein 1 (Twist1) is a widely recognized oncogene in acute myeloid leukemia (AML), and its promoter methylation is related with the progression of solid tumors. However, the association between Twist1 promoter methylation and AML has not been well studied. Twist1 mRNA expression was detected using quantitative real-time polymerase chain reaction (qRT-PCR). The protein levels of Twist1 and phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signal were measured via western blotting. Methylation-specific PCR was performed to detect the methylation status of Twist1 promoter. CCK-8 assay and flow c...
Source: Indian Journal of Hematology and Blood Transfusion - June 1, 2022 Category: Hematology Source Type: research

The Accuracy of Physical Examination to Diagnose Anemia Among Patients Five Years or Older: A Systematic Review
AbstractAnemia remains a significant public health challenge, disproportionately impacting lower-income patients residing in areas of lesser healthcare resources. We sought to evaluate the accuracy of physical exam techniques to diagnose anemia among patients 5  years of age or older. A systematic review of 5 databases (MEDLINE via OVID, EMBASE, Scopus, Global Health and Global Health Archives, and WHO Global Index Medicus) was conducted. Studies that (1) compared non-invasive physical exam techniques with anemia diagnoses using standard laboratory measur ements and (2) solely assessed or separately reported the diagnosti...
Source: Indian Journal of Hematology and Blood Transfusion - May 31, 2022 Category: Hematology Source Type: research

Single Dose of Ivermectin is not Useful in Patients with Hematological Disorders and COVID-19 Illness: A Phase II B Open Labelled Randomized Controlled Trial
AbstractRepurposed drugs may reduce morbidity and mortality in patients with hematological disorders who develop COVID-19 illness. 112 patients with predominantly hematological illnesses were randomized to receive standard of care, ivermectin 12  mg [Iv 12] or 24 mg [Iv24] for asymptomatic, mild, or moderate COVID 19 illness. Serial respiratory samples for rRT-PCR samples were sent on Day 3, 5 and 7. rRT-PCR negativity and ≥ 2 log10 reduction in viral loads on day 3, 5 and 7 were similar between the 3 treatment groups across all disease categories. Symptom progression occurred in 26 patients [21.6%] with no differe...
Source: Indian Journal of Hematology and Blood Transfusion - May 27, 2022 Category: Hematology Source Type: research

Safety and Efficacy of Bendamustine and Rituximab (BR) Regimen in Indian Chronic Lymphocytic Leukaemia Patients
AbstractWe investigated the safety and efficacy of bendamustine-rituximab (BR) in previously untreated symptomatic and advanced CLL patients, as there is no data available on BR from the Indian subcontinent.This retrospective study included 120 consecutive treatment na ïve patients with CLL without del (17p), who were registered at the Department of Medical Oncology, AIIMS between January 2010 and July 2018. Bendamustine was given at a dose of 90 mg/m2 on days 1 and 2, combined with rituximab 375  mg/m2 rituximab on day 1, every 28  days for up to 6 courses. Event-free survival (EFS) was defined as the date of treatmen...
Source: Indian Journal of Hematology and Blood Transfusion - May 27, 2022 Category: Hematology Source Type: research

Methodological Study on the Establishment of HLA/HPA Gene Bank of Platelet Donors and Its Clinical Application
AbstractThe current study aimed at establishing a large-scale platelet donor database with known HPA and HLA genotypes in Ningbo, to provide matched platelets for the clinic and prevent the occurrence of ineffective immune platelet transfusion refractoriness (PTR). The platelet banks of clinical donor wtih HLA-A, HLA-B, HPA1, HPA2, HPA3, HPA4, HPA5, HPA6, HPA10, HPA15 and HPA21 genotyps were established. Meanwile, the platelet gene matching was performed on the donor. It was found that there were phenotype polymorphisms in 1000 donnors with HPA1, HPA2, HPA3, HPA4, HPA5, HPA6, HPA10, HPA15 and HPA21 genotyps, and allel poly...
Source: Indian Journal of Hematology and Blood Transfusion - May 26, 2022 Category: Hematology Source Type: research

Awareness, Perception, and Practices Towards Blood Donation Among Undergraduate Health Science Students of India During the COVID-19 Pandemic
AbstractTo assess the awareness, perception, and practices of health science students towards blood donation during the COVID-19 pandemic. This cross-sectional study was done among the undergraduate medical, dental, physiotherapy, and audiology, speech and learning pathology students in May 2021. A self-administered questionnaire designed using Google Doc was used for data collection. Out of the 461 participants, only 171(37.1%) knew that Coronavirus was not transmitted through blood transfusion. Only 125(27.1%) participants knew that a minimum of 14  days is required before a donor who tested positive for COVID-19 can do...
Source: Indian Journal of Hematology and Blood Transfusion - May 19, 2022 Category: Hematology Source Type: research

Inhibitor; An Uncommon But Vexing Challenge In North Indian Patients With Hemophilia A
AbstractFactor VIII replacement is the mainstay of treatment in hemophilia A but may lead to the development of inhibitors. While a vexing clinical problem, some observations suggest that the presence of inhibitors may not necessarily portend a higher bleeding risk. Our aim was to assess the prevalence and clinicopathological correlates of inhibitors in a well characterized cohort of Indian patients with HA patients. We retrospectively reviewed the clinical details and laboratory findings of consecutive hemophilia A patients attending a north-Indian tertiary-care center from 2010 to 2020. Among 592 patients with HA, inhibi...
Source: Indian Journal of Hematology and Blood Transfusion - May 6, 2022 Category: Hematology Source Type: research

Cytogenetic Risk Stratification of B-Acute Lymphoblastic Leukemia and Its Correlation with Other Prognostic Factors
AbstractPurpose of current study was to categorize WHO defined B-Acute Lymphoblastic Leukemia (B-ALL) cases into 3 cytogenetic risk groups (good, intermediate and poor) and to see their correlation with age, NCI risk criteria and treatment response. Clinical and diagnostic details were collected for 78 newly diagnosed B-ALL patients which included bone marrow morphology, flow cytometry immunophenotyping, karyotyping, FISH and RT-PCR. Study cohort comprised 44/78 (56.4%) children including 3 infants and 34/78 (43.6%) adults. Median age for paediatric group was 6 years (3 months –17 years) and for adults was 40.5 years (18...
Source: Indian Journal of Hematology and Blood Transfusion - May 5, 2022 Category: Hematology Source Type: research

The Effect of Long-Term Iron Chelator Therapy on Serum Levels of Hepcidin and Ferritin in Patients with Thalassemia Major and Intermediate
AbstractSerum hepcidin is a good predictor of iron overload compared with serum ferritin. However, serum hepcidin levels may change under different conditions. The current study aims to determine the role of long-term iron chelator therapy on serum levels of hepcidin and ferritin in patients with thalassemia major (TM) and intermediate (TI). In this cross-sectional study 91 patients with thalassemia TM and TI, who referred to the thalassemia center were chosen. The serum levels of hepcidin and ferritin were measured after two years of iron chelator therapy by ELISA and ECL methods, respectively. The patients' demographic i...
Source: Indian Journal of Hematology and Blood Transfusion - May 4, 2022 Category: Hematology Source Type: research

‘Primary CNS Blastoid Variant of Mantle Cell Lymphoma: A Unique Case’
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - April 30, 2022 Category: Hematology Source Type: research

Safety and Efficacy of Thalidomide and Hydroxyurea Combination in Beta Thalassemia Patients
AbstractBeta thalassemia results from imbalance in alpha and beta globin chains causing severe anemia, transfusion dependency, and iron overload. Hematopoietic stem cell transplantation (HSCT) is the only curative treatment. Patients without the option of HSCT may benefit from Hemoglobin F (HbF) inducing agents like thalidomide and hydroxyurea (HU). We conducted a retrospective analysis on 87 beta thalassemia patients who received a combination of low dose thalidomide and HU from January 2017 to December 2020. Patients received combination of HU 500  mg everyday (>  30 kg) or every alternate day (<  30 kg) and...
Source: Indian Journal of Hematology and Blood Transfusion - April 21, 2022 Category: Hematology Source Type: research

Clinical Evaluation of Balance in Children With Hemophilic Arthropathy
ConclusionsTreatment and coagulation factor prophylaxis to prevent the onset of arthropathy will improve patients ’ quality of life and reduce morbidity associated with frequent falls and bleeding. (Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - April 21, 2022 Category: Hematology Source Type: research

Favorable HLA Polymorphisms are Associated with Lower Molecular Relapse after Tyrosine Kinase Discontinuation in Patients with Chronic Myeloid Leukemia
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - April 18, 2022 Category: Hematology Source Type: research