Indian Journal of Hematology and Blood Transfusion This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Metformin as a Fetal Hemoglobin Inducer in Non-transfusion Dependent Thalassemia Patients
Conclusion: Metformin intake, in addition to hydroxyurea, did not yield any extra benefit among patients with NTDT. (Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - May 5, 2023 Category: Hematology Source Type: research

A Potential Novel Entity for Polycythemia Vera: JAK2 Exon 24 Mutation
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - May 3, 2023 Category: Hematology Source Type: research

CG02N Analyzer Accurately Measures Fibrinogen Level in Whole Blood in the Presence of Low- or High-Dose Heparin
In this study, we aimed to investigate the accuracy of Fbg level measured using CG02N, with whole blood contained in lithium-heparinized syringes with two different concentrations of heparin. Blood samples were collected in lithium-heparinized tubes, namely PREZA-PAK ®II (low-dose heparin group [LG], 7 IU/mL) and Pro-Vent® Plus (high-dose heparin group [HG], 70.5 IU/mL). The Fbg levels in LG and HG were compared with those of citrated plasma Fbg (standard-Fbg). Strong correlations with respect to the Fbg level were observed between standard-Fbg and LG or HG (r = 0.968, p <  0.0001; r = 0.970, p < â€...
Source: Indian Journal of Hematology and Blood Transfusion - May 2, 2023 Category: Hematology Source Type: research

A Retrospective Cohort Study to Evaluate the Outcomes of HIV-Associated High-Grade B-Cell Non-Hodgkin Lymphoma (NHL) Treated with Dose Adjusted EPOCH (+/ −R) Regimen
We report our analysis on our cohort of patients who were treated with DA-EPOCH(+/−R). We retrospectively analyzed treatment-naïve HIV-associated High-grade B-cell NHL patients (ag ed ≥ 18) treated with DA-EPOCH(+/−R) regimen from 2011 to 2015. Descriptive statistics were summarized with median and range; survival outcomes were analyzed with Kaplan–Meier method. The cohort comprised of 40 patients [DLBCL(19), Burkitt’s Lymphoma(16), High-grade B-Cell Lymphoma-Uncla ssifiable(09), and Plasmablastic Lymphoma(01)] and the median CD4 + T cell count was 202/mm3. CNS prophylaxis was administered with intrathec...
Source: Indian Journal of Hematology and Blood Transfusion - April 21, 2023 Category: Hematology Source Type: research

Potential Clinical Role of LncRNA miR503HG in Multiple Myeloma and its Effect on the Proliferation and Adhesion of Myeloma Cells
This study mainly explored the role of lncRNA miR503HG in multiple myeloma and the potential downstream regulatory mechanism affecting disease. Real-time quantitative polymerase chain reaction was used to measure the expression levels of miR503HG and miR-103. A cell counting kit-8 assay was performed to detect cell viability. The concentrations of adhesion-related factors (MUC-1, VCAM-1, ICAM-1) were determined using enzyme-linked immunosorbent assay. The targeting relationship between miR503HG and miR-103 was detected by dual-luciferase reporter assay. The miR503HG expression in peripheral blood of multiple myeloma patien...
Source: Indian Journal of Hematology and Blood Transfusion - April 21, 2023 Category: Hematology Source Type: research

CMV Infection Post Allogeneic Hematopoietic Stem Cell Transplantation in a Resource Limited Country
AbstractCytomegalovirus (CMV) infection is one of the common complications which can lead to significant morbidity and mortality in patients after allogeneic hematopoietic stem cell transplantation (HSCT). As the seroprevalence of CMV infection in Malaysia is high, this study aims to determine the prevalence of CMV infection in patients post HSCT and to evaluate the associated risk factors. Patients who underwent allogeneic HSCT in adult ward from 2008 to 2020 at a tertiary teaching hospital in Kuala Lumpur, Malaysia were studied retrospectively. They were followed up for a minimum of 100  days post-HSCT to determine the ...
Source: Indian Journal of Hematology and Blood Transfusion - April 20, 2023 Category: Hematology Source Type: research

Germline CSF3R, RUNX1 and ETV6 Pathogenic Variants in a Case of Atypical Chronic Myeloid Leukemia: Individual to Familial Unravelling by Next Generation Sequencing
AbstractMyelodysplastic syndrome/Myeloproliferative neoplasm (MDS/MPN) overlap syndromes are recently identified entities that have been quite difficult to define due to overlapping morphological features and absence of a specific molecular abnormality. With the advent of Next- generation sequencing (NGS), discovery of new pathogenic variants has led to identification of clonal pathology in many of such cases. Here, we describe a case of atypical chronic myeloid leukemia with germ line predisposition where identical pathogenic variations were demonstrated in CSF3R, RUNX1 and ETV6 both in peripheral blood and buccal swab by...
Source: Indian Journal of Hematology and Blood Transfusion - April 20, 2023 Category: Hematology Source Type: research

Cytomegalovirus Reactivation as a Risk Factor for All-Cause Mortality in Children Undergoing Hematopoietic Stem Cell Transplantation: Experience Over Two Decades from a Tertiary Referral Center in India
AbstractThe aim of the study was to analyse the burden of cytomegalovirus (CMV) disease in children undergoing hematopoietic stem cell transplantation (HSCT) and its correlation with all-cause mortality. We performed a retrospective study in children up to 18  years of age who underwent allogeneic HSCT between February 2002 to December 2021 in the pediatric blood and marrow transplantation unit. A total of 1035 patients were included where five hundred forty-three (52.4%) patients underwent matched family donor (MFD) HSCT, 213 (20.5%) underwent matched unrelated donor (MUD) HSCT; 279 (26.9%) underwent haploidentical HSCT ...
Source: Indian Journal of Hematology and Blood Transfusion - April 17, 2023 Category: Hematology Source Type: research

Study of the Frequency and Specificity of Red Cell Antibodies in Patients with Hemoglobinopathies
This study included 200 multi transfused Egyptian patients, one hundred and forty patients with transfusion dependent thalassaemia and sixty patients with sickle cell anaemia, who were attending the Paediatric Children Hospital-Cairo University at the period from March 2019 to October 2019. Alloantibody identification was made by Diamed- ID microtyping system. In the studied groups both thalassemia and sickle patients, the prevalence of alloimmunization was 22/200 (11%) patients. The two most often alloantibodies were, antibodies against Kell antigen (37%) and against E antigen (30%). The prevalence of alloimmunization was...
Source: Indian Journal of Hematology and Blood Transfusion - April 17, 2023 Category: Hematology Source Type: research

Thyroid Dysfunction in Patients with and Without Venous Thromboembolism: a Case Control Study
AbstractRecent studies report an association between thyroid dysfunction and venous thromboembolism (VTE). Considering the high prevalence of thyroid diseases in India, identification of thyroid dysfunction as a risk factor for VTE will have implications in management. The aim of study was to determine if thyroid dysfunction could be considered as risk factor for unprovoked VTE. The study was conducted on 102 patients with unprovoked VTE and 102 age and gender matched controls in a tertiary care centre. Clinical profile and thyroid function tests (Free T3, Free T4, TSH) including antibody profile (Anti TPO and Anti TG) wer...
Source: Indian Journal of Hematology and Blood Transfusion - April 17, 2023 Category: Hematology Source Type: research

In-vitro Modulation of mTOR-HIF-1 α Axis by TLR7/8 Agonist (Resiquimod) in B-Chronic Lymphocytic Leukemia
AbstractTargeting toll-like receptors (TLRs), via TLR agonists, has been implicated in the regulation of immunometabolism. B-chronic lymphocytic leukemia (B-CLL) represents a suitable model for B-cell derived malignancies with shifted metabolic adaptations. Several signaling pathways have been found to be critical in metabolic reprogramming of CLL, including mechanistic target of rapamycin- hypoxia inducible factor-1 α (mTOR- HIF-1α) pathway, the main metabolic regulator of glycolysis. Here, we investigated the effect of TLR7/8 agonist (Resiquimod) on the expression of mTOR and HIF-1α in patients with CLL. B cells we...
Source: Indian Journal of Hematology and Blood Transfusion - April 7, 2023 Category: Hematology Source Type: research

Short-Term Impact of Hematopoietic Stem Cell Transplantation on Depressive Behavior, Cognition and Quality of Life in Leukemia Patients
In conclusion, post-30 days of HSCT there was alleviation in depressive behavior, cognition, and QoL in leukemia patients compared to before therapy.Graphical abstract (Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - April 4, 2023 Category: Hematology Source Type: research

Is Old (Fludrabine/Busulfan/Cyclophosphamide/rAntiThymocyteGlobulin) Conditioning Still Gold for Allogeneic Transplants in Transfusion Dependent Beta-Thalassemia of All Risk Categories in 21st Century?
AbstractAllogeneic stem cell transplant (allo-SCT) is the only curative option for transfusion dependent thalassemia (TDT) until the gene therapy could bring paradigm shift. We analysed TDT allo-SCTs performed with Flu/Bu/Cy/rATG conditioning between October 2018 and April 2022 at our center. A retrospective analysis of 55 consecutive HLA matched alloSCT for TDT and was approved by hospital ’s Institutional Review Board. Median age was 7(2–13) years. On presentation, number of patients with Class I, II, III were 18 (32.7%), 14(25.4%) and 23(41.8%) respectively {ClassIIIA = 14(25.4%),ClassIIIB = 9(16.3%)}. After...
Source: Indian Journal of Hematology and Blood Transfusion - April 3, 2023 Category: Hematology Source Type: research

Incidence, Risk Factors and Outcome of Bloodstream Infections in Patients After Hematopoietic Stem-Cell Transplantation: A Single Center Study
This study confirms that the fecal colonization with MDR bacteria before transplantation and pre-transplant BSIs are independent risk factors for the occurrence of BSI in the early period after HSCT. Pre- and posttransplant monitoring of the patient fecal coloniza tion status with MDR organisms, could contribute considerably to the prevention and successful management of the infectious complications in patients after HSCT. (Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - April 1, 2023 Category: Hematology Source Type: research

Minimal Residual Disease in the Management of B-Cell Acute Lymphoblastic Leukemia: A Systematic Review of Studies from Indian Settings
AbstractMinimal residual disease (MRD) has become an essential tool in the management of B-cell acute lymphoblastic leukemia (B-ALL) and aids in tailoring treatment strategies to suit specific patient needs. Although much progress has been made in this area, there is limited data on the use of MRD in the Indian context. Our objective was to identify relevant literature that discusses the utility of MRD in the management of B-cell ALL in adolescents and young adults (AYA) and adults in Indian settings. A systematic search and screening of articles were performed using the Preferred Reporting Items for Systematic Reviews and...
Source: Indian Journal of Hematology and Blood Transfusion - March 30, 2023 Category: Hematology Source Type: research