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The Diagnostic Potential of the L Score for ABO Hemolytic Disease of the Newborn: Insights from a Cross-Sectional Study
ConclusionThe L score represents a valuable tool for predicting neonatal hyperbilirubinemia and hemolytic disease, facilitating differentiation, and guiding early intervention for improved outcomes. Further research is warranted to validate and expand the applicability of the L score in clinical practice. (Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - January 5, 2024 Category: Hematology Source Type: research

Potential Role of Positivity Percentage of CD200 in the Mature B Cell Neoplasms
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - January 5, 2024 Category: Hematology Source Type: research

Establishment of Prognosis Nomogram for Primary Splenic Diffuse Large B Cell Lymphoma: A Study Based on SEER Database
This study aimed to establish a nomogram prediction model of overall survival in primary DLBCL of the spleen. We screened out 347 patients with primary splenic DLBCL from surveillance, epidemiology, and end results database. According to the Cox regression results (age, Ann Arbor Stage, splenectomy and chemotherapy was the independent risk factor for primary splenic DLBCL), the nomogram was constructed. We evaluated the predictive ability of nomogram with C-Index (training cohort: 0.719 [0.669 –0.769]; validation cohort: 0.711 [0.641–0.781]) and 3-year/5-year receiver operating characteristic area under curve (3-year/5...
Source: Indian Journal of Hematology and Blood Transfusion - January 3, 2024 Category: Hematology Source Type: research

Determinants of Variable Total Platelet Count in Healthy Plateletpheresis Donor
This study explores the factors affecting this variation in platelet count in healthy blood donors selected for platelet donation. This retrospective study comprises an analysis of platelet donor data between the year 2016 –2022. The pre-recorded donor details such as age, gender, blood group, body mass index (BMI), and complete blood counts were collected and analyzed using the software ‘R’ (version 4.1.0). The statistical analysis consists of a test of normalcy followed by descriptive details and advanced stat istics such as correlation and regression analysis to predict the variables affecting platelet count. Thep...
Source: Indian Journal of Hematology and Blood Transfusion - December 29, 2023 Category: Hematology Source Type: research

Haploidentical Stem Cell Transplantation: Half Match but More Hope! —Single Centre Experience from Western India
AbstractWith the success of post-transplant cyclophosphamide based platform and improved clinical care, the number of haploidentical stem cell transplants (HaploSCT) have surged over the last decade. However, data from India is scarce. We aimed to evaluate the outcome of haploSCT at our centre. Since the inception of government schemes, many patients at our centre are able to undergo transplantation at subsidized cost. We conducted a retrospective analysis of the haploidentical transplants performed between January 2015 and November 2022. Fifty patients were eligible for this study. Patient details were obtained from case ...
Source: Indian Journal of Hematology and Blood Transfusion - December 22, 2023 Category: Hematology Source Type: research

Vascular Tumor with Kasabach Merritt Phenomenon Treated with Steroids and Vincristine: A Retrospective Study
AbstractVascular tumours (VT) with Kasabach-Merritt phenomenon (KMP) are rare and aggressive tumors. In absence of evidence based treatment guidelines, we studied varied presentation and response to therapy with vincristine and steroids in VT with KMP at our center. In this retrospective observational study, infants with a symptomatic/disfiguring rapidly growing VT with features of KMP were included. Demographic, treatment and outcome data was retrieved from patient file. Complete response (CR) was defined as complete clinical regression of VT with normalization of coagulopathy and thrombocytopenia. Partial response (PR) w...
Source: Indian Journal of Hematology and Blood Transfusion - December 17, 2023 Category: Hematology Source Type: research

Effect of Vaccination on Seroprevalence of COVID-19 among Blood donors – A cross-sectional Analytic Study from South India
AbstractIndia achieved impressive strides by providing 1.7  billion doses of the COVID-19 vaccine to more than 940 million people, attaining 100% first dose coverage and 80% overall immunization coverage as of February 9, 2022. Compared to unvaccinated individuals, vaccinated people have considerably decreased risks of infection, serious illness, hospital ization, and death. With the help of this study, we determined the prevalence of COVID-19 IgG antibodies with respect to vaccination. The cross-sectional analytical study was conducted from July 2021 to April 2022 on 809 healthy donors. All donor samples were screened f...
Source: Indian Journal of Hematology and Blood Transfusion - December 16, 2023 Category: Hematology Source Type: research

Standardization of Anti-Xa Assay and its Comparison with Activated Partial Thromboplastin Time for Monitoring Unfractionated Heparin Therapy
This study aimed to compare the effectiveness of aPTT and anti-Xa assays in UFH monitoring. A prospective non-randomized study was carried out in two stages: first, the anti-Xa assay was standardized using kit instructions; each sample was then analyzed by both tests. The outcomes of the two assays were compared and assessed for agreement of maintaining therapeutic anticoagulant levels. These levels for anti-Xa assay were between 0.3 and 0.7  IU/ml, while it was 1.5–2.5 times the control for aPTT assay. Below this range was regarded as subtherapeutic, and above this as supratherapeutic. A total of 90 samples were tested...
Source: Indian Journal of Hematology and Blood Transfusion - December 15, 2023 Category: Hematology Source Type: research

AML With HIV Infection in The Era of Precision Oncology – Do We See The Light At The End of The Tunnel?
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - December 8, 2023 Category: Hematology Source Type: research

Weakening of A Antigen in Myelodysplastic Syndrome-Mimicking a Case of Wrong Blood in Tube
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - December 8, 2023 Category: Hematology Source Type: research

A Rare RhD-Phenotype Caused by Gene RHCE-D (1 –9)-CE (10)
(Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - December 7, 2023 Category: Hematology Source Type: research

The Utility of CD43 and CD200 in Differentiating Chronic Lymphocytic Leukemia from Other Mature B-Cell Neoplasms: A Cross Sectional Study
AbstractTo evaluate the utility of CD43 and CD200 in differentiating chronic lymphocytic leukemia (CLL) from other mature B-cell neoplasms. This was a cross-sectional study on patients diagnosed with B-cell neoplasms on flowcytometry. The median fluorescence intensity (MFI) of CD43, CD200 expressing neoplastic B-cells were compared between the CLL and non-CLL B-cell neoplasms followed by receiver operating characreristic curve (ROC) analysis. In addition, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of CD43 and CD200 in diagnosing CLL were analysed. A total of 137 patien...
Source: Indian Journal of Hematology and Blood Transfusion - November 30, 2023 Category: Hematology Source Type: research

Daratumumab for De-sensitization of Donor Specific Antibodies: Is it a Quicker and Easier way?
AbstractAntibodies directed against donor-specific HLA loci (DSA) has been proved as a main culprit for graft rejection, more specifically in HLA mismatched and haplo-identical transplant settings. There is no standardized regimen to manage the presence of DSAs in allogeneic stem cell transplantations (allo-SCTs). Most widely regimen includes combination of rituximab (anti CD20 antibody), Immunoglobulin (IVIG), plasma exchange, and buffy coat infusion, which is costly and time-consuming. Daratumumab (anti CD38 monoclonal antibody) is an effective therapeutic agent to deplete plasma cells and hence, it has a potential to re...
Source: Indian Journal of Hematology and Blood Transfusion - November 24, 2023 Category: Hematology Source Type: research

Common Hematological Reference Indices Among Healthy Reproductive Age Indian Women-Data Subset from Nationwide Study
This study aimed to generate normative ranges for various hematological parameters among these women. After ethics approval, apparen tly healthy (n = 5884) women (aged 18–40 years) were recruited from six eco-geographic zones of India. After various exclusions (n = 5412), including women having anemia, data of clinically, and biochemically healthy women (n = 472) was analysed to generate centiles (2.5 and 97.5th) a nd correlations. The mean age and mean BMI of women was 29.3 ± 6.5 years and 23.25 ± 3.26 kg/m2 with BP of 112.26  ± 8.9/74.04 ± 6.7 mmHg. The reference intervals for hemogl...
Source: Indian Journal of Hematology and Blood Transfusion - November 20, 2023 Category: Hematology Source Type: research

An Evaluation of Random Donor Platelets Prepared from Overnight Stored Buffy Coat Method: A Better Alternative to the 6-h Restriction
In this study total of eighty RDPs were prepared. Forty RDPs were prepared by each method by matching similar platelet counts in whole blood in pairs and avoiding other bias. Quality analysis was done in various hematological, biochemical, metabolic, and activation parameters and with National gui deline. RDPs prepared by the overnight stored buffy coat method had statistically higher mean platelet counts, lesser WBC contamination, lesser glucose concentration, higher lactate concentration, lesser pH, and higher MPV& PDW than RDPs prepared by the fresh buffy coat method. P selectin levels were lesser in the overnight ...
Source: Indian Journal of Hematology and Blood Transfusion - November 4, 2023 Category: Hematology Source Type: research