Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension

CONCLUSIONS: These data support the pathogenic role of CypD acetylation in endothelial dysfunction and hypertension. We suggest that targeting cytotoxic mitochondrial isolevuglandins and GCN5L1 reduces CypD acetylation, which may be beneficial in cardiovascular disease.PMID:38639088 | DOI:10.1161/CIRCRESAHA.123.323596

Source: Circulation Research - April 19, 2024 Category: Cardiology Authors: Anna Dikalova Daniel Fehrenbach Vladimir Mayorov Alexander Panov Mingfang Ao Louise Lantier Venkataraman Amarnath Marcos G Lopez Frederic T Billings Iv Michael N Sack Sergey Dikalov Source Type: research