Combined treatment with dissolved hydrogen molecule and platinum nanocolloid exerts carcinostatic/carcinocidal effects by increasing hydrogen peroxide generation and cell death in the human gastric cancer cell line NUGC-4
In conclusion, combined treatment with H2 and Pt-nc can induce carcinostatic/carcinocidal effects through intracellular ROS increase, morphological changes, cell death, and DNA synthesis suppression in the human tumor cell line.PMID:33929281 | DOI:10.1080/10715762.2021.1902514 (Source: Free Radical Research)
Source: Free Radical Research - April 30, 2021 Category: Research Authors: Yasukazu Saitoh Naho Kawasaki Natsumi Eguchi Minoru Ikeshima Source Type: research

Reactive oxygen species: the root cause of nanoparticle-induced toxicity in < em > Drosophila melanogaster < /em >
Free Radic Res. 2021 Apr 20:1-17. doi: 10.1080/10715762.2021.1914335. Online ahead of print.ABSTRACTNanotechnology is a rapidly developing technology in the twenty-first century. Nanomaterials are extensively used in numerous industries including cosmetics, food, medicines, industries, agriculture, etc. Along with its wide application toxicity is also reported from studies of various model organisms including Drosophila. The toxicity reflects cytotoxicity, genotoxicity, and teratogenicity. The current study correlates the toxicity as a consequence of reactive oxygen species (ROS) generated owing to the presence of nanopart...
Source: Free Radical Research - April 20, 2021 Category: Research Authors: Monalisa Mishra Mrutyunjaya Panda Source Type: research

Lipid composition dictates the rate of lipid peroxidation in artificial lipid droplets
Free Radic Res. 2021 Apr 19:1-12. doi: 10.1080/10715762.2021.1898603. Online ahead of print.ABSTRACTCellular and organismal redox imbalance leading to the accumulation of reactive oxygen species significantly enhances lipid peroxidation (LPO). LPO is relatively well studied for phospholipid membranes and to some extent for circulating lipoproteins. However, it is rarely addressed for intracellular lipid droplets (LDs). Here we optimized an in vitro model system to investigate oxidizability of different lipid classes within artificial LDs (aLDs). To this end, aLDs were reconstructed using differential centrifugation and cha...
Source: Free Radical Research - April 19, 2021 Category: Research Authors: Mike Lange Pia Viktoria Wagner Maria Fedorova Source Type: research

The effect of a color tattoo on the local skin redox regulatory network: an N-of-1 study
Free Radic Res. 2021 Apr 15:1-9. doi: 10.1080/10715762.2021.1912340. Online ahead of print.ABSTRACTBiomedical aspects of tattooing have been extensively discussed in literature, however pathophysiological effects of tattoo inks in the human body are still unexplored. Oxidative stress is considered responsible for the adverse effects of tattooing, however no experimental evidence for tattoo ink-related oxidative stress in the human body currently exists. The aim was to examine the effect of a blue tattoo on skin redox regulatory network (RRN) parameters in a single human subject. Skin surface oxidation-reduction potential (...
Source: Free Radical Research - April 15, 2021 Category: Research Authors: Jan Homolak Source Type: research

Iron metabolism: an emerging therapeutic target underlying the anti-cancer effect of quercetin
Free Radic Res. 2021 Apr 5:1-8. doi: 10.1080/10715762.2021.1898604. Online ahead of print.ABSTRACTIron, an essential micronutrient for all kinds of cells, is essential for the balance of body internal environment. Notably, cancer cells exhibit a strong dependence on iron and require a large amount of iron for proliferation. A growing number of studies suggested that iron metabolism imbalance and subsequent excess iron accumulation are closely related to the occurrence and progression of cancer. Precisely, excess iron promotes the development of cancer due to the pro-oxidative nature of iron and its damaging effects on DNA....
Source: Free Radical Research - April 5, 2021 Category: Research Authors: Mingming Yin Yongping Liu Yi Chen Source Type: research

Effect of Rosolic acid on endothelial dysfunction under ER stress in pancreatic microenvironment
In this study, using a co-culture system, the crosstalk between pancreatic cells under ER stress and ECs and the effect of a novel Nrf2 activator Rosolic Acid (RA), on the crosstalk was investigated. ECs pre-treated with different concentrations RA and co-cultured with thapsigargin-induced ER stressed pancreatic β-cells showed increased levels of Nrf2 and its downstream targets such as heme oxygenase-1 (HO-1) and NADPH-quinone oxidoreductase-1 (NQO-1), and reduction of ER stress evinced by the decreased levels of glucose-regulated protein (GRP) 78 and C/ERB homologous protein (CHOP). The sensitization of ECs using RA,...
Source: Free Radical Research - March 31, 2021 Category: Research Authors: Karan Naresh Amin Rajaguru Palanisamy D V L Sarada Daoud Ali Takayoshi Suzuki Kunka Mohanram Ramkumar Source Type: research

Heavy-ion beam-induced reactive oxygen species and redox reactions
Free Radic Res. 2021 Mar 17:1-11. doi: 10.1080/10715762.2021.1899171. Online ahead of print.ABSTRACTQuantification and local density estimation of radiation-induced reactive oxygen species (ROS) were described focusing on our recent and related studies. Charged particle radiation, i.e. heavy-ion beams, are currently utilized for medical treatment. Differences in ROS generation properties between photon and charged particle radiation may lead to differences in the quality of radiation. Radiation-induced generation of ROS in water was quantified using several different approaches to electron paramagnetic resonance (EPR) tech...
Source: Free Radical Research - March 17, 2021 Category: Research Authors: Ken-Ichiro Matsumoto Megumi Ueno Yoshimi Shoji Ikuo Nakanishi Source Type: research

Exercise associated with γ-oryzanol supplementation suppresses oxidative stress and prevents changes in locomotion in < em > Drosophila melanogaster < /em >
This study main evaluates the effect of exercise (EXE) associated with γ-oryzanol (ORY) supplementation to improve locomotor behavior, antioxidant defenses, and survival in Drosophila melanogaster. Two-day old flies were submitted to a protocol for seven days, divided into five groups: Control, Sedentary, EXE, ORY [25µM], and EXE + ORY [25µM]. The survival rate was evaluated, followed by open field and negative geotaxis. Flies were euthanized and subjected to analysis for acetylcholinesterase (AChE) and antioxidant enzymes activity, glycidic and lipid parameters, body weight, reactive species (RS), and li...
Source: Free Radical Research - March 3, 2021 Category: Research Authors: Mustafa Munir Mustafa Dahleh St ífani Machado Araujo Vandreza Cardoso Bortolotto Franciane Cabral Pinheiro M árcia Rósula Poetini Elize Aparecida Santos Musachio Luana Barreto Meichtry Shanda de Freitas Couto Marina Prigol Source Type: research