Mixed exposure to haloacetaldehyde disinfection by-products exacerbates lipid aggregation in the liver of mice
Environ Pollut. 2024 Apr 17:123971. doi: 10.1016/j.envpol.2024.123971. Online ahead of print.ABSTRACTHaloacetaldehyde disinfection by-products (HAL-DBPs) are among the top three unregulated DBPs found in drinking water. The cytotoxicity and genotoxicity of HALs are much higher than that of the regulated trihalomethanes and haloacetic acids. Previous studies have mainly focused on the toxic effects of single HALs, with few examining the toxic effects of mixed exposures to HALs. The study aimed to observe the effects of mixed exposures of 1∼1000X the realistic level of HALs on the hepatotoxicity and lipid metabolism of C57...
Source: Environmental Pollution - April 19, 2024 Category: Environmental Health Authors: Meiyue Qiu Lili Yang Zhiqiang Jiang Yu Chen Qinxin Liu Xia Wang Weidong Qu Source Type: research
Le miR-224-5p r égulé sert de biomarqueur pour l'insuffisance hépatique aiguë pédiatrique et régule l'inflammation en modulant ZBTB20
This study focused on evaluating the clinical significance of miR-224-5p in PALF and revealing its potential molecular mechanism in regulating liver cell injury. This study enrolled 103 children with PALF and 55 healthy children without liver diseases. Serum miR-224-5p levels were compared between the two groups, and their clinical significance was estimated by analyzing the correlation with clinicopathological features and outcomes of PALF children. In vitro, a normal liver cell was treated with lipopolysaccharide (LPS), and cell growth and inflammation were assessed by CCK8 and ELISA assay. Upregulated miR-224-5p in PALF...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Qin Wang Gaoyin Zhang Mengmeng Zhang Yunxia Zhang Lianying Ruan Hengrui Hao Source Type: research
Reply to: "Starting the journey: Understanding the roles of complement proteins in liver diseases through mendelian randomization"
Clin Mol Hepatol. 2024 Apr 19. doi: 10.3350/cmh.2024.0266. Online ahead of print.NO ABSTRACTPMID:38637982 | DOI:10.3350/cmh.2024.0266 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 19, 2024 Category: Gastroenterology Authors: Yingzhou Shi Guandou Yuan Xiude Fan Chao Xu Source Type: research
Role of ghrelin hormone in the development of alcohol-associated liver disease
In this study, we used a ghrelin receptor (GHSR) knockout (KO) rat model to characterize the specific contribution of ghrelin in the development of ALD with emphasis on energy homeostasis. Male Wistar wild type (WT) and GHSR-KO rats were pair-fed the Lieber-DeCarli control or ethanol diet for 6 weeks. At the end of the feeding period, glucose tolerance test was conducted, and tissue samples were collected. We observed reduced alcohol intake by GHSR-KOs compared to a previous study where WT rats were fed ethanol diet ad libitum. Further, when the WTs were pair-fed to GHSR-KOs, the KO rats exhibited resistance to develop ALD...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 19, 2024 Category: Drugs & Pharmacology Authors: Sundararajan Mahalingam Ramesh Bellamkonda Kusum K Kharbanda Madan Kumar Arumugam Vikas Kumar Carol A Casey Lorenzo Leggio Karuna Rasineni Source Type: research
RPL9 acts as an oncogene by shuttling miRNAs through exosomes in human hepatocellular carcinoma cells
Int J Oncol. 2024 Jun;64(6):58. doi: 10.3892/ijo.2024.5646. Epub 2024 Apr 19.ABSTRACTThe exosomal pathway is an essential mechanism that regulates the abnormal content of microRNAs (miRNAs) in hepatocellular carcinoma (HCC). The directional transport of miRNAs requires the assistance of RNA‑binding proteins (RBPs). The present study found that RBPs participate in the regulation of miRNA content through the exosomal pathway in HCC cells. First, differential protein expression profiles in the serum exosomes of patients with HCC and benign liver disease were detected using mass spectrometry. The results revealed that riboso...
Source: International Journal of Oncology - April 19, 2024 Category: Cancer & Oncology Authors: Ang Li Jiyan Xie Lihong Lv Zhihua Zheng Weibang Yang Wenfeng Zhuo Sijia Yang Diankui Cai Jinxin Duan Peiqing Liu Jun Min Jinxing Wei Source Type: research
Evaluation of Two Palliative Clinics for Patients with Kidney Disease on Dialysis and Patients with Liver Disease
1. Upon successful completion, participants will understand the importance of integrating palliative care into the management of end-stage kidney disease on dialysis and end-stage liver disease and be able to formulate strategies to overcome barriers in providing access to palliative care for patients with non-cancer diseases.2. Upon successful completion, participants will be aware of the effectiveness of using a collaborative model of care within outpatient PC clinics for patients with end-stage kidney disease on dialysis and end-stage liver disease in terms of achieving outcomes outlined in the logic model. (Source: Jou...
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Aria Wills, Leila Cohen, Grace Warmels, Adrianna Bruni, Sarina R. Isenberg Source Type: research
Qualitative Study of Longitudinal Specialty-Aligned Palliative Care for Inpatients with Advanced Liver Disease
1. Describe the benefits of a longitudinal model of specialty-aligned inpatient palliative care for patients with advanced liver disease.2. Understand key areas of need to improve end-of-life care delivery for patients with advanced liver disease. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Nneka Ufere, Nancy Mason, Kirsten G. Engel, Michaela Rowland, Samantha S. Berliss, Erin Plews-Ogan, Sara D'Arpino, Karen O'Brien, Lucinda Li, Teresa Indriolo, Enya Zhu, Brett Nava-Coulter, Anna C. Revette, Vicki Jackson, Areej El-Jawahri Source Type: research
The association between score of plant-based diet and non-alcoholic fatty liver disease in adults
Plant-based diet(PDI) as resource of antioxidants and anti-inflammatory phytochemicals, that was considered to protect against onset and development of Non-alcoholic fatty liver disease (NAFLD). (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - April 19, 2024 Category: Nutrition Authors: Azadeh Fallah, Hamid abdolazimi, Zahra Darabi, Nasir Talenezhad, Farhang Mirzavandi, Shahab Rahimpour, Mahdieh Hosseinzadeh Source Type: research
Comment on “Echopattern parameter as an aid to profile Crohn's disease patients”
With a great interest in its subject matter, we extensively reviewed and analyzed an interesting article that was recently published by your journal, entitled “Echopattern parameter as a tool for characterizing Crohn's disease patients' profiles [1]”, authored by Cristofaro et al. We commend the Authors for their innovative efforts. Their core findings suggest that the assessment of bowel wall echopattern enables the differentiation of various Crohn's Disease (CD) behaviors, particularly noting that a hypoechoic echopattern correlates with both clinical and ultrasonographic (US) markers of inflammation, as well as poor...
Source: Digestive and Liver Disease - April 19, 2024 Category: Gastroenterology Authors: Muhammad Rafay Shahzad Cheema, Mukarram Farooq, Urba Jalal, Maryum Shahzad Tags: Correspondence Source Type: research
Relationship between phthalates exposures and metabolic dysfunction-associated fatty liver disease in United States adults
This study included 3,137 adults from the National Health and Nutrition Ex amination Survey spanning 2007–2018. The diagnosis of MAFLD depended on the US Fatty Liver Index (US FLI) and evidence of metabolic dysregulation. Eleven metabolites of PAEs were included in the study. Poisson regression, restricted cubic spline (RCS), and weighted quantile sum (WQS) regression we re used to assess the associations between phthalate metabolites and MAFLD. After adjusting for potential confounders, Poisson regression analysis showed that mono-2-ethyl-5-carboxypentyl phthalate (MECPP), mono-n-butyl phthalate, mono-(3-carboxypropyl) ...
Source: PLoS One - April 19, 2024 Category: Biomedical Science Authors: Junhao Sun Source Type: research
Molecules, Vol. 29, Pages 1859: A Systematic Review of Statins for the Treatment of Nonalcoholic Steatohepatitis: Safety, Efficacy, and Mechanism of Action
Bing Liu
Nonalcoholic fatty liver disease (NAFLD) is the liver component of a cluster of conditions, while its subtype, nonalcoholic steatohepatitis (NASH), emerges as a potentially progressive liver disorder that harbors the risk of evolving into cirrhosis and culminating in hepatocellular carcinoma (HCC). NASH and cardiovascular disease (CVD) have common risk factors, but compared to liver-related causes, the most common cause of death in NASH patients is CVD. Within the pharmacological armamentarium, statins, celebrated for their lipid-modulating prowess, have now garnered attention for their expansive therapeutic ...
Source: Molecules - April 19, 2024 Category: Chemistry Authors: Shiqin Zhang Xiaoling Ren Bingzheng Zhang Tian Lan Bing Liu Tags: Review Source Type: research
Metabolomics of Mice with Type 2 Diabetes and Nonalcoholic Fatty Liver Treated by Acupuncture
CONCLUSION: Our study shows that acupuncture can regulate the liver metabolism mode of T2DM in NAFLD mice. It can reduce blood glucose and lipid accumulation in the liver, and these findings provide a new idea and theoretical basis for acupuncture in the treatment of diseases related to glucose and lipid metabolism.PMID:38633528 | PMC:PMC11023731 | DOI:10.1155/2024/5568337 (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - April 18, 2024 Category: Endocrinology Authors: Yihui Guo Liying Zhang Mengyuan Li Linan Lin Fuyu Xue Wanning Gao Xiaoru Xu Haipeng Huang Source Type: research
Gliflozins in the Treatment of Non-diabetic Experimental Cardiovascular Diseases
Physiol Res. 2024 Apr 18. Online ahead of print.ABSTRACTA new class of antidiabetic drugs - gliflozins (inhibitors of sodium glucose cotransporter-2; SGLT-2i) stimulate glucose and sodium excretion, thereby contributing to improved glycemic control, weight loss and blood pressure reduction in diabetic patients. Large clinical trials in patients with type 2 diabetes treated with empagliflozin, canagliflozin or dapagliflozin have demonstrated their excellent efficacy in improving many cardiovascular outcomes, including the reduction of death from cardiovascular diseases, non-fatal myocardial infarction or stroke, and hospita...
Source: Physiological Research - April 18, 2024 Category: Physiology Authors: I Van ěčková J Zicha Source Type: research
Metabolomics of Mice with Type 2 Diabetes and Nonalcoholic Fatty Liver Treated by Acupuncture
CONCLUSION: Our study shows that acupuncture can regulate the liver metabolism mode of T2DM in NAFLD mice. It can reduce blood glucose and lipid accumulation in the liver, and these findings provide a new idea and theoretical basis for acupuncture in the treatment of diseases related to glucose and lipid metabolism.PMID:38633528 | PMC:PMC11023731 | DOI:10.1155/2024/5568337 (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - April 18, 2024 Category: Endocrinology Authors: Yihui Guo Liying Zhang Mengyuan Li Linan Lin Fuyu Xue Wanning Gao Xiaoru Xu Haipeng Huang Source Type: research
LDL-C and TC mediate the risk of PNPLA3 inhibition on cardiovascular diseases
CONCLUSION: This study suggests that PNPLA3 inhibition increases the risk of major CVDs. Moreover, blood LDL-C and TC may mediate a significant proportion of the associations between PNPLA3 inhibition and coronary atherosclerosis, coronary heart disease, or myocardial infarction.PMID:38636099 | DOI:10.1210/clinem/dgae264 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 18, 2024 Category: Endocrinology Authors: Genshan Zhang Wei Jiang Fangxun He Jie Fu Xiangshang Xu Xuelai Luo Zhixin Cao Source Type: research
