Efficacy and Safety of Fibroblast Growth Factor-21 Analogs for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis: A Systematic Review and Meta-Analysis
Clin Pharmacol Ther. 2024 Apr 26. doi: 10.1002/cpt.3278. Online ahead of print.ABSTRACTFibroblast growth factor (FGF)-21 analogs are potential therapeutic candidates for metabolic dysfunction-associated steatohepatitis (MASH). This systematic review and meta-analysis aimed to assess the efficacy and safety of the FGF-21 analogs, efruxifermin, pegbelfermin, and pegozafermin for MASH treatment. A comprehensive systematic review and meta-analysis of randomized controlled trials from five major databases was conducted. Primary efficacy outcomes focused on liver histological improvement, while secondary efficacy outcomes encomp...
Source: Clinical Pharmacology and Therapeutics - April 26, 2024 Category: Drugs & Pharmacology Authors: Changhyeon Jeong Nayoung Han Nakyung Jeon Su-Jin Rhee Christine E Staatz Min-Soo Kim In-Hwan Baek Source Type: research
GSE230700 Lipid droplet-mediated danger signaling balances Trem2+ macrophage induction and NLRP3 inflammasome activation in NASH
Contributors : Linkang Zhou ; Xiaoxue Qiu ; Tongyu Liu ; You Lu ; Siming Li ; Jiandie D LinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMacrophages are exquisitely capable of sensing danger-associated molecular patterns (DAMPs) and orchestrating inflammatory response during tissue injury. Nonalcoholic steatohepatitis (NASH) represents an advanced stage of metabolic fatty liver disease that increases the risk for cirrhosis and liver cancer. Pathogenic mechanisms of NASH center on hepatocyte injury and the ensuing immune response within the liver microenvironment. However, the n...
Source: GEO: Gene Expression Omnibus - April 26, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Clinical manifestation, epidemiology, genetic basis, potential molecular targets, and current treatment of polycystic liver disease
Polycystic liver disease (PLD) is a rare condition observed in three genetic diseases, including autosomal dominant polycystic liver disease (ADPLD), autosomal dominant polycystic kidney disease (ADPKD), and a... (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - April 26, 2024 Category: Internal Medicine Authors: Amir Ali Mahboobipour, Moein Ala, Javad Safdari Lord and Arash Yaghoobi Tags: Review Source Type: research
Fasting hyperglycaemia and fatty liver drive colorectal cancer: a retrospective analysis in 1145 patients
ConclusionMASLD and increased FPG may play a role in the clinical background of CRC, bringing to light the fascinating possibility of a reversed gut –liver axis communication in the pathogenesis of CRC. Thus, the use of non-invasive scores of fatty liver may be helpful to predict the risk of CRC and serve as novel prognostic factors for prevention and therapeutic strategies. (Source: Internal and Emergency Medicine)
Source: Internal and Emergency Medicine - April 26, 2024 Category: Emergency Medicine Source Type: research
Risk factors and a nomogram for predicting local recurrence in adult patients with early gastric cancer after endoscopic submucosal dissection
Endoscopic submucosal dissection (ESD) is an effective treatment method for early gastric cancers. The aim of this study was to evaluate the risk factors of recurrence for patients with early gastric cancer after ESD and construct a nomogram for predicting recurrence. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 26, 2024 Category: Gastroenterology Authors: Shaoya Li, Ainun Nahar, Qian Zhang, Jie Xing, Peng Li, Shutian Zhang, Xiujing Sun Tags: Oncology Source Type: research
Primary squamous cell carcinoma of the pancreas causing regional portal hypertension
A female patient presented with epigastric pain with black stools and laboratory results suggesting positive fecal occult blood and higher than normal CA199. Upper abdominal CT (Fig. 1a,b) and magnetic resonance (Fig. 1c) suggested the possibility of pancreatic cervical body occupying lesions, involving the portal vein, splenic vein and superior mesenteric vein. Ultrasound-guided puncture biopsy of pancreatic mass was performed, and invasive carcinoma was detected (Fig. 1d). Immunohistochemistry results: P40 (Fig. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 26, 2024 Category: Gastroenterology Authors: Jingzhi Zhang, Daocong Ren, Qingshun Meng Tags: Image of the Month Source Type: research
Determinants, profile and outcomes of hepatitis A virus –associated severe acute liver injury in adults
ConclusionHAV presents as s-ALI in young adults, with almost one in 10 progressing to ALF. Baseline ammonia may be an important predictor of progression even in s-ALI, but mandates larger well-designed studies.Graphical abstract (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - April 26, 2024 Category: Gastroenterology Source Type: research
Molecules, Vol. 29, Pages 1999: Gallic Acid Can Promote Low-Density Lipoprotein Uptake in HepG2 Cells via Increasing Low-Density Lipoprotein Receptor Accumulation
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Xuanjun Wang
Gallic acid (GA) is a type of polyphenolic compound that can be found in a range of fruits, vegetables, and tea. Although it has been confirmed it improves non-alcoholic fatty liver disease (NAFLD), it is still unknown whether GA can improve the occurrence of NAFLD by increasing the low-density lipoprotein receptor (LDLR) accumulation and alleviating cholesterol metabolism disorders. Therefore, the present study explored the effect of GA on LDLR and its mechanism of action. The findings indicated that the increase in LDLR accumulation in HepG2 cells induced by GA was associated with the stimulation of...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Dongying Zhang Qixing Zhou Xiangxuan Yang Zhen Zhang Dongxue Wang Dandan Hu Yewei Huang Jun Sheng Xuanjun Wang Tags: Article Source Type: research
Response to: The Synergism of Public Health Policies and Social Work May Reduce Mortality from Cancer, Liver Disease and Cardiovascular Disease
We appreciate the interest that emerged from our recent publication [1], ‘Association between public health policies on alcohol and worldwide cancer, liver disease, and cardiovascular disease outcomes’ [2]. In our research, we evidenced a strong relationship between alcohol-related public health policies (PHP) establishment and the decrease of alcohol-related health consequences over time among 169 countries, including liver disease and other significant causes of burden of disease worldwide. These associations were stronger over time, and consistent with the framework SAFER proposed by the World Health Organization (W...
Source: Journal of Hepatology - April 26, 2024 Category: Gastroenterology Authors: Luis Antonio D íaz, Eduardo Fuentes-López, Juan Pablo Arab Tags: Letter to the Editor Source Type: research
Viruses, Vol. 16, Pages 682: Reduction of the Risk of Hepatocellular Carcinoma over Time Using Direct-Acting Antivirals: A Propensity Score Analysis of a Real-Life Cohort (PITER HCV)
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Anna Linda Zignego
Carmine Coppola
Andrea Iannone
Elisa Biliotti
Elena Rosselli Del Turco
Marco Massari
Anna Licata
Francesco Barbaro
Marcello Persico
Filomena Morisco
Maurizio Pompili
Federica Cerini
Massimo Puoti
Teresa Santantonio
Antonio Craxì
Loreta A. Kondili
Liliana Chemello Investigators
on behalf of PITER Collaborating Investigators on behalf of PITER Collaborating Investigators
The treatment of hepatitis C virus (HCV) with direct-acting antivirals (DAA) leads to high sustained virological response (SVR) rates, but hepatocellular carcinoma (HCC) risk persists in peop...
Source: Viruses - April 26, 2024 Category: Virology Authors: Maria Giovanna Quaranta Luisa Cavalletto Francesco Paolo Russo Vincenza Calvaruso Luigina Ferrigno Alberto Zanetto Benedetta Mattioli Roberta D ’Ambrosio Valentina Panetta Giuseppina Brancaccio Giovanni Raimondo Maurizia Rossana Brunetto Anna Linda Zign Tags: Article Source Type: research
Full Title Page /Editorial Board
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 25, 2024 Category: Gastroenterology Source Type: research
Revisiting liver metabolism through acetyl-CoA carboxylase inhibition
Trends Endocrinol Metab. 2024 Apr 24:S1043-2760(24)00093-6. doi: 10.1016/j.tem.2024.04.010. Online ahead of print.ABSTRACTLiver-targeted acetyl-coenzyme A (CoA) carboxylase (ACC) inhibitors in metabolic dysfunction-associated steatotic liver disease (MASLD) trials reveal notable secondary effects: hypertriglyceridemia and altered glucose metabolism, paradoxically with reduced hepatic steatosis. In their study, Deja et al. explored how hepatic ACC influences metabolism using different pharmacological and genetic methods, coupled with targeted metabolomics and stable isotope-based tracing techniques.PMID:38664153 | DOI:10.10...
Source: Trends in Endocrinology and Metabolism: TEM - April 25, 2024 Category: Endocrinology Authors: Armando Jes ús Pérez-Díaz Mar ía Ángeles Núñez-Sánchez Bruno Ramos-Molina Source Type: research
Cellular strategies to induce immune tolerance after liver transplantation: Clinical perspectives
World J Gastroenterol. 2024 Apr 7;30(13):1791-1800. doi: 10.3748/wjg.v30.i13.1791.ABSTRACTLiver transplantation (LT) has become the most efficient treatment for pediatric and adult end-stage liver disease and the survival time after transplantation is becoming longer due to the development of surgical techniques and perioperative management. However, long-term side-effects of immunosuppressants, like infection, metabolic disorders and malignant tumor are gaining more attention. Immune tolerance is the status in which LT recipients no longer need to take any immunosuppressants, but the liver function and intrahepatic histol...
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Ai-Wei Zhou Jing Jin Yuan Liu Source Type: research
Bayesian network-based survival prediction model for patients having undergone post-transjugular intrahepatic portosystemic shunt for portal hypertension
CONCLUSION: This study successfully developed a BN-based survival prediction model with good predictive capabilities. It offers valuable insights for treatment strategies and prognostic evaluations in patients having undergone TIPS surgery for PHT.PMID:38659484 | PMC:PMC11036496 | DOI:10.3748/wjg.v30.i13.1859 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Rong Chen Ling Luo Yun-Zhi Zhang Zhen Liu An-Lin Liu Yi-Wen Zhang Source Type: research
Novel subtype of obesity influencing the outcomes of sleeve gastrectomy: Familial aggregation of obesity
CONCLUSION: FAO patients is associated with decreased mid-to-long-term weight loss outcomes; the alleviation of T2DM, hyperlipidemia and NAFLD; and decreased incidence of acid reflux postoperatively.PMID:38659480 | PMC:PMC11036498 | DOI:10.3748/wjg.v30.i13.1887 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Ze-Yu Wang Yun-Fei Qu Tian-Ming Yu Zeng-Lin Liu Yu-Gang Cheng Ming-Wei Zhong San-Yuan Hu Source Type: research
