Jian Gan powder ameliorates immunological liver injury in mice by modulating the gut microbiota and metabolic profiles
ConclusionsJGP intervention improves ILI by restoring gut microbiota and modifying its metabolic profiles. These results provide a novel insight into the mechanism of JGP in treating ILI and the scientific basis to support its clinical application. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 20, 2024 Category: Research Source Type: research
Le miR-224-5p r égulé sert de biomarqueur pour l'insuffisance hépatique aiguë pédiatrique et régule l'inflammation en modulant ZBTB20
This study focused on evaluating the clinical significance of miR-224-5p in PALF and revealing its potential molecular mechanism in regulating liver cell injury. This study enrolled 103 children with PALF and 55 healthy children without liver diseases. Serum miR-224-5p levels were compared between the two groups, and their clinical significance was estimated by analyzing the correlation with clinicopathological features and outcomes of PALF children. In vitro, a normal liver cell was treated with lipopolysaccharide (LPS), and cell growth and inflammation were assessed by CCK8 and ELISA assay. Upregulated miR-224-5p in PALF...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Qin Wang Gaoyin Zhang Mengmeng Zhang Yunxia Zhang Lianying Ruan Hengrui Hao Source Type: research
Le miR-224-5p r égulé sert de biomarqueur pour l'insuffisance hépatique aiguë pédiatrique et régule l'inflammation en modulant ZBTB20
This study focused on evaluating the clinical significance of miR-224-5p in PALF and revealing its potential molecular mechanism in regulating liver cell injury. This study enrolled 103 children with PALF and 55 healthy children without liver diseases. Serum miR-224-5p levels were compared between the two groups, and their clinical significance was estimated by analyzing the correlation with clinicopathological features and outcomes of PALF children. In vitro, a normal liver cell was treated with lipopolysaccharide (LPS), and cell growth and inflammation were assessed by CCK8 and ELISA assay. Upregulated miR-224-5p in PALF...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Qin Wang Gaoyin Zhang Mengmeng Zhang Yunxia Zhang Lianying Ruan Hengrui Hao Source Type: research
Le miR-224-5p r égulé sert de biomarqueur pour l'insuffisance hépatique aiguë pédiatrique et régule l'inflammation en modulant ZBTB20
This study focused on evaluating the clinical significance of miR-224-5p in PALF and revealing its potential molecular mechanism in regulating liver cell injury. This study enrolled 103 children with PALF and 55 healthy children without liver diseases. Serum miR-224-5p levels were compared between the two groups, and their clinical significance was estimated by analyzing the correlation with clinicopathological features and outcomes of PALF children. In vitro, a normal liver cell was treated with lipopolysaccharide (LPS), and cell growth and inflammation were assessed by CCK8 and ELISA assay. Upregulated miR-224-5p in PALF...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Qin Wang Gaoyin Zhang Mengmeng Zhang Yunxia Zhang Lianying Ruan Hengrui Hao Source Type: research
Le miR-224-5p r égulé sert de biomarqueur pour l'insuffisance hépatique aiguë pédiatrique et régule l'inflammation en modulant ZBTB20
This study focused on evaluating the clinical significance of miR-224-5p in PALF and revealing its potential molecular mechanism in regulating liver cell injury. This study enrolled 103 children with PALF and 55 healthy children without liver diseases. Serum miR-224-5p levels were compared between the two groups, and their clinical significance was estimated by analyzing the correlation with clinicopathological features and outcomes of PALF children. In vitro, a normal liver cell was treated with lipopolysaccharide (LPS), and cell growth and inflammation were assessed by CCK8 and ELISA assay. Upregulated miR-224-5p in PALF...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Qin Wang Gaoyin Zhang Mengmeng Zhang Yunxia Zhang Lianying Ruan Hengrui Hao Source Type: research
Reply to: "Starting the journey: Understanding the roles of complement proteins in liver diseases through mendelian randomization"
Clin Mol Hepatol. 2024 Apr 19. doi: 10.3350/cmh.2024.0266. Online ahead of print.NO ABSTRACTPMID:38637982 | DOI:10.3350/cmh.2024.0266 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 19, 2024 Category: Gastroenterology Authors: Yingzhou Shi Guandou Yuan Xiude Fan Chao Xu Source Type: research
RPL9 acts as an oncogene by shuttling miRNAs through exosomes in human hepatocellular carcinoma cells
Int J Oncol. 2024 Jun;64(6):58. doi: 10.3892/ijo.2024.5646. Epub 2024 Apr 19.ABSTRACTThe exosomal pathway is an essential mechanism that regulates the abnormal content of microRNAs (miRNAs) in hepatocellular carcinoma (HCC). The directional transport of miRNAs requires the assistance of RNA‑binding proteins (RBPs). The present study found that RBPs participate in the regulation of miRNA content through the exosomal pathway in HCC cells. First, differential protein expression profiles in the serum exosomes of patients with HCC and benign liver disease were detected using mass spectrometry. The results revealed that riboso...
Source: International Journal of Oncology - April 19, 2024 Category: Cancer & Oncology Authors: Ang Li Jiyan Xie Lihong Lv Zhihua Zheng Weibang Yang Wenfeng Zhuo Sijia Yang Diankui Cai Jinxin Duan Peiqing Liu Jun Min Jinxing Wei Source Type: research
Reply to: "Starting the journey: Understanding the roles of complement proteins in liver diseases through mendelian randomization"
Clin Mol Hepatol. 2024 Apr 19. doi: 10.3350/cmh.2024.0266. Online ahead of print.NO ABSTRACTPMID:38637982 | DOI:10.3350/cmh.2024.0266 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 19, 2024 Category: Gastroenterology Authors: Yingzhou Shi Guandou Yuan Xiude Fan Chao Xu Source Type: research
Le miR-224-5p r égulé sert de biomarqueur pour l'insuffisance hépatique aiguë pédiatrique et régule l'inflammation en modulant ZBTB20
This study focused on evaluating the clinical significance of miR-224-5p in PALF and revealing its potential molecular mechanism in regulating liver cell injury. This study enrolled 103 children with PALF and 55 healthy children without liver diseases. Serum miR-224-5p levels were compared between the two groups, and their clinical significance was estimated by analyzing the correlation with clinicopathological features and outcomes of PALF children. In vitro, a normal liver cell was treated with lipopolysaccharide (LPS), and cell growth and inflammation were assessed by CCK8 and ELISA assay. Upregulated miR-224-5p in PALF...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Qin Wang Gaoyin Zhang Mengmeng Zhang Yunxia Zhang Lianying Ruan Hengrui Hao Source Type: research
Dried tangerine peel polysaccharide (DTPP) alleviates hepatic steatosis by suppressing TLR4/MD-2-mediated inflammation and endoplasmic reticulum stress
This study provides a potential molecular mechanism underlying the anti-inflammatory effects of DTPP on NAFLD and suggests DTPP as a promising therapeutic strategy for NAFLD treatment.PMID:38640721 | DOI:10.1016/j.bioorg.2024.107369 (Source: Bioorganic Chemistry)
Source: Bioorganic Chemistry - April 19, 2024 Category: Chemistry Authors: Lingzhi Wang Wenxi Li Yinggang Li Gengrui Chen Lijuan Zhao Wu Li Shengwei Wang Chunming Wang Yanxian Feng Yibo Zhang Source Type: research
An allosteric inhibitor of sirtuin 2 blocks hepatitis B virus covalently closed circular DNA establishment and its transcriptional activity
In this study, we investigated the antiviral properties of a newly described allosteric modulator, FLS-359, that targets sirtuin 2 (SIRT2), an NAD+-dependent deacylase. Our results demonstrate that SIRT2 modulation by FLS-359 and by other tool compounds inhibits cccDNA synthesis following de novo infection of primary human hepatocytes and HepG2 (C3A)-NTCP cells, and FLS-359 substantially reduces cccDNA recycling in HepAD38 cells. While pre-existing cccDNA is not eradicated by short-term treatment with FLS-359, its transcriptional activity is substantially impaired, likely through inhibition of viral promoter activities. Co...
Source: Antiviral Research - April 19, 2024 Category: Virology Authors: Liudi Tang Stacy Remiszewski Andrew Snedeker Lillian W Chiang Thomas Shenk Source Type: research
Mixed exposure to haloacetaldehyde disinfection by-products exacerbates lipid aggregation in the liver of mice
Environ Pollut. 2024 Apr 17:123971. doi: 10.1016/j.envpol.2024.123971. Online ahead of print.ABSTRACTHaloacetaldehyde disinfection by-products (HAL-DBPs) are among the top three unregulated DBPs found in drinking water. The cytotoxicity and genotoxicity of HALs are much higher than that of the regulated trihalomethanes and haloacetic acids. Previous studies have mainly focused on the toxic effects of single HALs, with few examining the toxic effects of mixed exposures to HALs. The study aimed to observe the effects of mixed exposures of 1∼1000X the realistic level of HALs on the hepatotoxicity and lipid metabolism of C57...
Source: Environmental Pollution - April 19, 2024 Category: Environmental Health Authors: Meiyue Qiu Lili Yang Zhiqiang Jiang Yu Chen Qinxin Liu Xia Wang Weidong Qu Source Type: research
Le miR-224-5p r égulé sert de biomarqueur pour l'insuffisance hépatique aiguë pédiatrique et régule l'inflammation en modulant ZBTB20
This study focused on evaluating the clinical significance of miR-224-5p in PALF and revealing its potential molecular mechanism in regulating liver cell injury. This study enrolled 103 children with PALF and 55 healthy children without liver diseases. Serum miR-224-5p levels were compared between the two groups, and their clinical significance was estimated by analyzing the correlation with clinicopathological features and outcomes of PALF children. In vitro, a normal liver cell was treated with lipopolysaccharide (LPS), and cell growth and inflammation were assessed by CCK8 and ELISA assay. Upregulated miR-224-5p in PALF...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Qin Wang Gaoyin Zhang Mengmeng Zhang Yunxia Zhang Lianying Ruan Hengrui Hao Source Type: research
Reply to: "Starting the journey: Understanding the roles of complement proteins in liver diseases through mendelian randomization"
Clin Mol Hepatol. 2024 Apr 19. doi: 10.3350/cmh.2024.0266. Online ahead of print.NO ABSTRACTPMID:38637982 | DOI:10.3350/cmh.2024.0266 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 19, 2024 Category: Gastroenterology Authors: Yingzhou Shi Guandou Yuan Xiude Fan Chao Xu Source Type: research
Role of ghrelin hormone in the development of alcohol-associated liver disease
In this study, we used a ghrelin receptor (GHSR) knockout (KO) rat model to characterize the specific contribution of ghrelin in the development of ALD with emphasis on energy homeostasis. Male Wistar wild type (WT) and GHSR-KO rats were pair-fed the Lieber-DeCarli control or ethanol diet for 6 weeks. At the end of the feeding period, glucose tolerance test was conducted, and tissue samples were collected. We observed reduced alcohol intake by GHSR-KOs compared to a previous study where WT rats were fed ethanol diet ad libitum. Further, when the WTs were pair-fed to GHSR-KOs, the KO rats exhibited resistance to develop ALD...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 19, 2024 Category: Drugs & Pharmacology Authors: Sundararajan Mahalingam Ramesh Bellamkonda Kusum K Kharbanda Madan Kumar Arumugam Vikas Kumar Carol A Casey Lorenzo Leggio Karuna Rasineni Source Type: research
