Colorectal Oncologic Emergencies: Recognition, Management, and Outcomes
Surg Clin North Am. 2024 Jun;104(3):631-646. doi: 10.1016/j.suc.2023.12.003. Epub 2023 Dec 18.ABSTRACTColorectal cancer is the third most frequent type of malignancy in the United States, and the age at diagnosis is decreasing. Although the goal of screening is focused on prevention and early detection, a subset of patients inevitably presents as oncologic emergencies. Approximately 15% of patients with colorectal cancer will present as surgical emergencies, with the majority being due to either colonic perforation or obstruction. Patients presenting with colorectal emergencies are a challenging cohort, as they often prese...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Joshua Sullivan Alec Donohue Shaun Brown Source Type: research
Biodegradable Microspheres for Transarterial Chemoembolization in Malignant Liver Disease
Medicina (Kaunas). 2024 Apr 22;60(4):678. doi: 10.3390/medicina60040678.ABSTRACTTransarterial chemoembolization (TACE) has revolutionized the treatment landscape for malignant liver disease, offering localized therapy with reduced systemic toxicity. This manuscript delves into the use of degradable microspheres (DMS) in TACE, exploring its potential advantages and clinical applications. DMS-TACE emerges as a promising strategy, offering temporary vessel occlusion and optimized drug delivery. The manuscript reviews the existing literature on DMS-TACE, emphasizing its tolerability, toxicity, and efficacy. Notably, DMS-TACE d...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Ornella Moschovaki-Zeiger Nikolaos-Achilleas Arkoudis Athanasios Giannakis Stavros Grigoriadis Fotis Anagnostopoulos Stavros Spiliopoulos Source Type: research
The Predictive Factors Associated with In-Hospital Mortality of Melioidosis: A Cohort Study
Conclusions: Our study identified age, respiration rate, abnormal chest X-ray finding, and CO2 levels are predictive factors associated with in-hospital mortality in melioidosis patients. Physicians should be aware of these factors, have access to aggressive treatment options, and closely monitor patients with these risk factors.PMID:38674300 | PMC:PMC11052379 | DOI:10.3390/medicina60040654 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Sunee Chayangsu Chusana Suankratay Apichat Tantraworasin Jiraporn Khorana Source Type: research
Incidence of cirrhosis in Iceland-impact of the TraP HepC nationwide HCV elimination program
CONCLUSION: During the past two decades, the incidence of cirrhosis has increased extraordinarily in Iceland, associated with increased alcohol consumption, obesity, and HCV. ALD and MASLD now collectively make up two thirds of cases in Iceland. Following a nationwide elimination program, incidence of HCV cirrhosis has dropped rapidly in Iceland.PMID:38676467 | DOI:10.1080/00365521.2024.2345384 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 27, 2024 Category: Gastroenterology Authors: Halldor A Haraldsson Sigurdur Olafsson Magnus Gottfredsson Ubaldo Benitez Hernandez Einar S Bjornsson Source Type: research
Synthesis of a new 2-prenylated quinoline as potential drug for metabolic syndrome with pan-PPAR activity and anti-inflammatory effects
Bioorg Med Chem Lett. 2024 Apr 26;106:129770. doi: 10.1016/j.bmcl.2024.129770. Online ahead of print.ABSTRACTWe have previously reported the total synthesis and structure-activity relationships (SAR) of 2-prenylated benzopyrans with PPAR agonist activity. Herein, we have described the synthesis and PPAR activity of 2-prenylated benzopyrans and 2-prenylated quinolines. The benzopyran nucleus was generated via enamine-catalyzed Kabbe condensation, and the quinoline nucleus via Friedländer condensation. Results demonstrated that both benzopyran (5a) and quinoline (4b) derivatives bearing a γ,δ-unsaturated ester displayed a...
Source: Bioorganic and Medicinal Chemistry Letters - April 27, 2024 Category: Chemistry Authors: Carlos Villarroel-Vicente Ainhoa Garc ía Khamis Zibar Mar ía Ayelén Schiel Jordi Ferri Nathalie Hennuyer Ricardo D Enriz Bart Staels Diego Cortes Nuria Cabedo Source Type: research
Colorectal Oncologic Emergencies: Recognition, Management, and Outcomes
Surg Clin North Am. 2024 Jun;104(3):631-646. doi: 10.1016/j.suc.2023.12.003. Epub 2023 Dec 18.ABSTRACTColorectal cancer is the third most frequent type of malignancy in the United States, and the age at diagnosis is decreasing. Although the goal of screening is focused on prevention and early detection, a subset of patients inevitably presents as oncologic emergencies. Approximately 15% of patients with colorectal cancer will present as surgical emergencies, with the majority being due to either colonic perforation or obstruction. Patients presenting with colorectal emergencies are a challenging cohort, as they often prese...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Joshua Sullivan Alec Donohue Shaun Brown Source Type: research
Biodegradable Microspheres for Transarterial Chemoembolization in Malignant Liver Disease
Medicina (Kaunas). 2024 Apr 22;60(4):678. doi: 10.3390/medicina60040678.ABSTRACTTransarterial chemoembolization (TACE) has revolutionized the treatment landscape for malignant liver disease, offering localized therapy with reduced systemic toxicity. This manuscript delves into the use of degradable microspheres (DMS) in TACE, exploring its potential advantages and clinical applications. DMS-TACE emerges as a promising strategy, offering temporary vessel occlusion and optimized drug delivery. The manuscript reviews the existing literature on DMS-TACE, emphasizing its tolerability, toxicity, and efficacy. Notably, DMS-TACE d...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Ornella Moschovaki-Zeiger Nikolaos-Achilleas Arkoudis Athanasios Giannakis Stavros Grigoriadis Fotis Anagnostopoulos Stavros Spiliopoulos Source Type: research
The Predictive Factors Associated with In-Hospital Mortality of Melioidosis: A Cohort Study
Conclusions: Our study identified age, respiration rate, abnormal chest X-ray finding, and CO2 levels are predictive factors associated with in-hospital mortality in melioidosis patients. Physicians should be aware of these factors, have access to aggressive treatment options, and closely monitor patients with these risk factors.PMID:38674300 | PMC:PMC11052379 | DOI:10.3390/medicina60040654 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Sunee Chayangsu Chusana Suankratay Apichat Tantraworasin Jiraporn Khorana Source Type: research
The circAno6/miR-296-3p/TLR4 signaling axis mediates the inflammatory response to induce the activation of hepatic stellate cells
CONCLUSION: This study suggests that circAno6 and miR-296-3p/TLR4 may form a regulatory axis and regulate the inflammatory response, which in turn induces HSC activation. Targeting circAno6 may be a potential therapeutic strategy to treat LF.PMID:38677350 | DOI:10.1016/j.gene.2024.148497 (Source: Gene)
Source: Gene - April 27, 2024 Category: Genetics & Stem Cells Authors: Zhen Li Yanzhen Ma Chang Fan Hui Jiang Source Type: research
3D culture models to study pathophysiology of steatotic liver disease
This article provides an overview of liver 3D models highlighting advantages and limitations, and culminates by discussing their applications in pharmaceutical and biomedical research.PMID:38677899 | DOI:10.1016/j.atherosclerosis.2024.117544 (Source: Atherosclerosis)
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Andrea Caddeo Samantha Maurotti Lohitesh Kovooru Stefano Romeo Source Type: research
Platelet, Antiplatelet Therapy and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Narrative Review
Life (Basel). 2024 Apr 4;14(4):473. doi: 10.3390/life14040473.ABSTRACTMetabolic dysfunction-associated steatotic liver disease (MASLD) is not only related to traditional cardiovascular risk factors like type 2 diabetes mellitus and obesity, but it is also an independent risk factor for the development of cardiovascular disease. MASLD has been shown to be independently related to endothelial dysfunction and atherosclerosis. MASLD is characterized by a chronic proinflammatory response that, in turn, may induce a prothrombotic state. Several mechanisms such as endothelial and platelet dysfunction, changes in the coagulative f...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Andrea Boccatonda Lorenza Del Cane Lara Marola Damiano D'Ardes Gianfranco Lessiani Nicoletta di Gregorio Claudio Ferri Francesco Cipollone Carla Serra Francesca Santilli Fabio Piscaglia Source Type: research
Colorectal Oncologic Emergencies: Recognition, Management, and Outcomes
Surg Clin North Am. 2024 Jun;104(3):631-646. doi: 10.1016/j.suc.2023.12.003. Epub 2023 Dec 18.ABSTRACTColorectal cancer is the third most frequent type of malignancy in the United States, and the age at diagnosis is decreasing. Although the goal of screening is focused on prevention and early detection, a subset of patients inevitably presents as oncologic emergencies. Approximately 15% of patients with colorectal cancer will present as surgical emergencies, with the majority being due to either colonic perforation or obstruction. Patients presenting with colorectal emergencies are a challenging cohort, as they often prese...
Source: Clinical Colorectal Cancer - April 27, 2024 Category: Cancer & Oncology Authors: Joshua Sullivan Alec Donohue Shaun Brown Source Type: research
Undifferentiated HepaRG cells show reduced sensitivity to the toxic effects of M8OI through a combination of CYP3A7-mediated oxidation and a reduced reliance on mitochondrial function
Food Chem Toxicol. 2024 Apr 25:114681. doi: 10.1016/j.fct.2024.114681. Online ahead of print.ABSTRACTThe methylimidazolium ionic liquid M8OI (1-octyl-3-methylimidazolium chloride, also known as [C8mim]Cl) has been detected in the environment and may represent a hazard trigger for the autoimmune liver disease primary biliary cholangitis, based in part on studies using a rat liver progenitor cell. The effect of M8OI on an equivalent human liver progenitor (undifferentiated HepaRG cells; u-HepaRG) was therefore examined. u-HepaRG cells were less sensitive (>20-fold) to the toxic effects of M8OI. The relative insensitivity ...
Source: Food and Chemical Toxicology - April 27, 2024 Category: Food Science Authors: Tarek M Abdelghany Shireen A Hedya Alex Charlton Fahad A Aljehani Khalid Alanazi Alaa A Budastour Larissa Marin Matthew C Wright Source Type: research
Incidence of cirrhosis in Iceland-impact of the TraP HepC nationwide HCV elimination program
CONCLUSION: During the past two decades, the incidence of cirrhosis has increased extraordinarily in Iceland, associated with increased alcohol consumption, obesity, and HCV. ALD and MASLD now collectively make up two thirds of cases in Iceland. Following a nationwide elimination program, incidence of HCV cirrhosis has dropped rapidly in Iceland.PMID:38676467 | DOI:10.1080/00365521.2024.2345384 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 27, 2024 Category: Gastroenterology Authors: Halldor A Haraldsson Sigurdur Olafsson Magnus Gottfredsson Ubaldo Benitez Hernandez Einar S Bjornsson Source Type: research
Synthesis of a new 2-prenylated quinoline as potential drug for metabolic syndrome with pan-PPAR activity and anti-inflammatory effects
Bioorg Med Chem Lett. 2024 Apr 25:129770. doi: 10.1016/j.bmcl.2024.129770. Online ahead of print.ABSTRACTWe have previously reported the total synthesis and structure-activity relationships (SAR) of 2-prenylated benzopyrans with PPAR agonist activity. Herein, we have described the synthesis and PPAR activity of 2-prenylated benzopyrans and 2-prenylated quinolines. The benzopyran nucleus was generated via enamine-catalyzed Kabbe condensation, and the quinoline nucleus via Friedländer condensation. Results demonstrated that both benzopyran (5a) and quinoline (4b) derivatives bearing a γ,δ-unsaturated ester displayed a pan...
Source: Bioorganic and Medicinal Chemistry Letters - April 27, 2024 Category: Chemistry Authors: Carlos Villarroel-Vicente Ainhoa Garc ía Khamis Zibar Mar ía Ayelén Schield Jordi Ferri Nathalie Hennuyer Ricardo D Enriz Bart Staels Diego Cortes Nuria Cabedo Source Type: research
