Pro-adrenomedullin in acute decompensation of liver cirrhosis: relationship with acute-on-chronic liver failure and short-term survival.
Authors: Yan H, Jin S, Liang L, Du J, Aithal GP, Li L Abstract Background and aim: Acute-on-chronic liver failure (ACLF) is characterized by the presence of acute decompensation (AD) of cirrhosis, organ failures, and high short-term mortality rates. In present study, we explored whether Pro-adrenomedullin (Pro-ADM), a biomarker of sepsis, is a potential marker of outcome in patients admitted for AD or ACLF and whether it might be of additional value to conventional prognostic scoring systems in these patients.Methods: 332 consecutive patients with AD of cirrhosis were prospectively enrolled. Pro-ADM was measured fo...
Source: Scandinavian Journal of Gastroenterology - June 2, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Biopsy rate and nonalcoholic steatohepatitis (NASH) in patients with nonalcoholic fatty liver disease (NAFLD).
Conclusion: The biopsy rate in NAFLD patients is low and fibrosis ≥ F2 along with NAS ≥4 only present in a few cases. Transient elastography and FIB-4 are useful to select patients at risk for fibrosis for liver biopsy. PMID: 32476514 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 2, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Everolimus and long-term decline in renal function after liver transplantation: real-life experience with measured GFR.
In conclusion, despite an early improvement in renal function after everolimus introduction, we found no evidence that everolimus halts the long-term mGFR decline compared to continued low-dose CNI therapy. Due to retrospective design, small sample size and heterogenous characteristics, definite conclusions require prospective studies. PMID: 32479116 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 2, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Letter to the editor regarding "Potential for prevention: a cohort study of colonoscopies and removal of adenomas in a FIT-based colorectal cancer screening programme".
Letter to the editor regarding "Potential for prevention: a cohort study of colonoscopies and removal of adenomas in a FIT-based colorectal cancer screening programme". Scand J Gastroenterol. 2020 Jun 01;:1-2 Authors: Thomsen MK, Støvring H, Mikkelsen EM PMID: 32479193 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 2, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Methylation patterns in dysplasia in inflammatory bowel disease patients.
Conclusions: Methylation analysis, namely of MSH6, may contribute to the classification of dysplastic lesions in IBD- to be further tested in prospective studies. PMID: 32456486 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 29, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The role of surgery in patients aged 85 years or older with resectable gastric cancer: a propensity score matching analysis of the SEER database.
This study aimed to explore the prognosis of a large sample of the oldest old GC patients receiving surgery.Methods: A total of 2914 oldest old patients with stage I-III GC were included in the linked Surveillance, Epidemiology, and End Results (SEER) database from 2006 to 2015. Based on their treatment, we assigned these patients to the surgery and no surgery groups. We used propensity score matching (1:1) to balance the baseline characteristics. The Kaplan-Meier method was used for the survival analysis. Multivariate Cox regression analysis was used to analyse the independent risk factors.Results: After propensity score ...
Source: Scandinavian Journal of Gastroenterology - May 29, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Cancer-risk by family history and mismatch-repair mutation in Lynch syndrome.
Conclusion: This cohort demonstrates the effectiveness of LS surveillance and suggests possible tailored surveillance strategies by gene mutation and family history. PMID: 32448028 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 26, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Downregulation of PHF19 inhibits cell growth and migration in gastric cancer.
Conclusions: We identified PHF19 as an oncogene candidate and provided a new potential drug target for gastric cancer. PMID: 32449434 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 26, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Predictors of health-related quality of life in patients with moderate to severely active ulcerative colitis receiving biological therapy.
Conclusions: Health-related quality of life was most prominently associated with bowel frequency during daytime, urgency of defecation, and blood in stool. Other symptoms associated for some health-related quality of life dimensions, and appear to vary between the sexes. PMID: 32442051 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 23, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Quantification of mucosal EEC in jejunum. A comparative study of IBS patients and healthy controls.
Conclusions: Counting cells per mm2 mucosal area gives a better representation of the number of EEC in small bowel mucosa. The finding of no difference in EEC numbers does not imply an equal function and further studies are needed to evaluate the role, if any of EEC, in IBS. PMID: 32442056 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 23, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Investigation of morphological and functional changes in the liver and pancreas during bevacizumab treatment.
Conclusions: Although bevacizumab caused atrophy of the pancreas and reduced pancreatic volume, pancreatic endocrine function showed no change. Future studies should investigate the survival rate and functional changes caused by bevacizumab treatment. PMID: 32432961 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 22, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

DUAL-POEM for associated esophageal and gastric motility disorders: case series of endoscopic cardiomyotomy and endoscopic pyloromyotomy.
Conclusions: DUAL POEM seems to be faisable in patient with esophageal motility disorders associated with gastroparesis. The possibility of the concomitant occurrence of esophageal and gastric motility disorders could lead to change in practices with an overall assessment including gastric empting scintigraphy, high resolution manometry and pH-impedancemetry for patients with digestive motility disorders. PMID: 32419525 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 19, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Prevalence of functional dyspepsia-like symptoms in ulcerative colitis patients in clinical remission and overlap with irritable bowel syndrome-like symptoms.
Conclusions: Although the prevalence of FD-like symptoms in quiescent UC patients with IBS-like symptoms was low, UC patients with FD-like symptoms frequently had IBS-like symptoms. PMID: 32412797 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 16, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Beta-adrenergic receptor blockers and liver cancer mortality in a national cohort of hepatocellular carcinoma patients.
Conclusion: β-blocker use was associated with lower liver cancer mortality rate in this national cohort of patients with HCC. A higher-magnitude inverse association was observed in relation to non-selective β-blocker use. PMID: 32412855 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 16, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Extracellular vesicle-associated soluble CD163 and CD206 in patients with acute and chronic inflammatory liver disease.
Authors: Nielsen MC, Andersen MN, Grønbæk H, Damgaard Sandahl T, Møller HJ Abstract Background: Extracellular vesicles (EVs) are implicated in intercellular communication in liver diseases. An EV-associated fraction of the macrophage biomarker soluble CD163, denoted EV-CD163, was recently identified. EV-CD163 may be released during later phases of the inflammatory response as opposed to the acute shedding of CD163 ectodomain (Ecto-CD163). Total sCD163 is a well-described biomarker in liver inflammation, and we investigated the distribution of CD163 fractions along with EV-associated soluble CD20...
Source: Scandinavian Journal of Gastroenterology - May 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

A young male with epitheliolysis in the small bowel and colon.
Conclusion: The true cause of this very serious situation with severe gastrointestinal involvement is not fully understood. In this case, successive treatment with antibiotics and isotretinoin given to a patient with an inflamed colon might have triggered the destruction of the epithelial barrier, leading to an immense immunological reaction in the intestinal wall. We suggest that physicians should be aware of UC-like symptoms occurring prior to or during treatment with tetracyclines and/or isotretinoin. PMID: 32393134 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Type 1 diabetes, thyroid, gastric and adrenal humoral autoantibodies are present altogether in almost one third of adult celiac patients at diagnosis, with a higher frequency than children and adolescent celiac patients.
Authors: Tiberti C, Panimolle F, Borghini R, Montuori M, Trovato CM, Filardi T, Lenzi A, Picarelli A Abstract Background: No data are available on the frequency of organ-specific humoral autoimmunity at diagnosis of adult celiac disease (CD).Aim: To evaluate the humoral immunoreactivities specific of type 1 diabetes (T1D), thyroid (THD), atrophic-gastritis (AG) and Addison's (AD) diseases in 92 adult CD patients at diagnosis and 237 adult healthy subjects (CTRL).Methods: T1D, THD and AD specific autoantibodies were analyzed by radioimmunoprecipitation assays. AG autoantibodies were detected by enzyme-linked immunos...
Source: Scandinavian Journal of Gastroenterology - May 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Clinical importance of main pancreatic duct variants and possible correlation with pancreatic diseases.
Conclusion: To elucidate linkage between MPD variants and the occurrence of chronic pancreatitis and impairment of pancreatic exocrine function, further clinical investigations are warranted. PMID: 32393143 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The use of ICD codes to identify IBD subtypes and phenotypes of the Montreal classification in the Swedish National Patient Register.
Conclusions: Among people with known IBD, the NPR is a reliable source of data to classify most subtypes of prevalent IBD, even though misclassification commonly occurred in Crohn's disease location and behaviour and also among IBD-unclassified patients. PMID: 32370571 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 8, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

High risk of non-alcoholic liver disease mortality in patients with chronic hepatitis C with illicit substance use disorder.
Conclusions: The relative risks for non-alcoholic liver disease mortality were elevated for patients with ISUD. Having ISUD was a significant independent factor for non-alcoholic liver disease. Thus, patients with HCV with ISUD should be given HCV treatment to reduce the risk for liver disease. PMID: 32356496 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 3, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Reflections after 10 years as Editor, including 8 years as Editor-in-Chief in Scandinavian Journal of Gastroenterology.
Authors: Waldum HL PMID: 32352880 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 2, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

True Chromogranin a concentrations in plasma from patients with small intestinal neuroendocrine tumours.
Conclusion: Available commercial immunoassays measure CgA in plasma with gross variability. Three commercial CgA immunoassays discriminate so poorly between health and disease that they should not be used. The highest diagnostic accuracy was obtained with processing-independent measurement of total CgA concentrations in plasma. PMID: 32352887 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 2, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Acute severe attacks of ulcerative colitis in a population-based cohort: epidemiology, treatment and outcome.
Conclusions: Acute severe attacks of ulcerative colitis appeared early after diagnosis and if surgery was escaped, there was no increased need for surgery in case of a new severe attack later. PMID: 32338997 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 29, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Intestinal inflammatory profile shows increase in a diversity of biomarkers in irritable bowel syndrome.
Conclusions: A dysregulated mucosal inflammatory profile with an increased level of TH1, TH2 and TH17 markers, and growth factors were observed in bowel mucosa in of IBS patients when compared to healthy controls. PMID: 32329383 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 26, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Evaluation of two functional CD24 polymorphisms in primary sclerosing cholangitis.
Conclusion: Our results suggest a mild association of the rs8734 CD24 genotype with dominant strictures at first diagnosis of PSC. The rs3838646 CD24 genotype is associated with a lower rate of IBD. Both SNPs seem to modulate the clinical phenotype without major pathogenetic importance for disease progression in PSC. PMID: 32329406 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 26, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Faecal microbiota transplantation for eradication of co-infection with Clostridioides difficile and extensively drug-resistant KPC-producing Klebsiella pneumoniae.
Authors: Bahl MI, Jørgensen SMD, Skriver AH, Larsen NA, Wang M, Licht TR, Dahlerup JF, Hvas CL Abstract Clostridioides difficile infection may be complicated by co-infection with other pathogens. We here describe the successful use of faecal microbiota transplantation to eradicate concomitant C. difficile and extensively drug-resistant (XDR) KPC-producing Klebsiella pneumoniae. Donor microbiota efficiently engrafted in the patient, and a donor-like microbial assemblage persisted in the patient during six months follow-up. The report explores the potential for the donor microbiota to eradicate and replace mul...
Source: Scandinavian Journal of Gastroenterology - April 25, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Prediction of adenoma recurrence after piecemeal endoscopic mucosal resection: interobserver agreement and utilization of the Sydney EMR recurrence tool.
Authors: Silva JC, Pinho R, Fernades C, Proença L, Rodrigues A, Silva AP, Ponte A, Rodrigues J, Sousa M, Gomes AC, Afecto E, Carvalho J Abstract Background and aims: Piecemeal endoscopic mucosal resection (pEMR) allows resection of larger non-invasive colorectal lesions. Adenoma recurrence is an important limitation and occurs in ≤20%. The present study aimed to validate the Sydney EMR recurrence tool (SERT) score as a predictor of both endoscopic and histologic recurrence and evaluate interobserver agreement in adenoma recurrence based on endoscopic scar assessment, among nonexperts in EMR.Methods...
Source: Scandinavian Journal of Gastroenterology - April 25, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Is there any association between overweight, physical activity, fat and fiber intake with functional constipation in adolescents?
Conclusions: The prevalence of constipation was high among this group of adolescents. Constipation was not associated with physical inactivity but was associated with a low dietary fiber intake and higher BMI values in female adolescents. PMID: 32320314 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 23, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Plasma levels of guanylins are reduced in patients with Crohn's disease.
Conclusion: Our data indicate that diarrhea may be a determinant for levels of proGN in plasma, and should be further explored in studies of different diarrheal disorders. PMID: 32306784 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 22, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Large-scale epidemiological data on vascular disorders of the intestine.
Conclusions: Our analysis demonstrates that the clinical and societal burden of vascular disorders of the intestine is especially higher in women, in the elderly and in people with higher socioeconomic status. PMID: 32301364 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 19, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Clinical results and microbiota changes after faecal microbiota transplantation for chronic pouchitis: a pilot study.
Conclusions: Symptomatic benefit in FMT treatment was found for four of nine patients with chronic pouchitis with increased microbial diversity and high engraftment of donor's microbiota. A larger, randomised controlled study is required to fully evaluate the potential role of FMT in treating chronic pouchitis. PMID: 32285709 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 16, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Which obesity-associated parameters can better reflect the risk of the occurrence of the anastomotic leakage?
Conclusions: Serum triglycerides have potential as a predictive indicator for AL, which may improve the treatment and outcomes of patients with AL. PMID: 32285713 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 16, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Clinical features and monocyte/macrophage subsets characterization in granulomatous vs non-granulomatous Crohn's disease.
Conclusions: Granulomatous CD patients exhibited different manifestations compared with their non-granulomatous counterparts. More aggressive therapy may be needed in granulomatous CD patients. Furthermore, the heterogeneity of monocyte/macrophage subsets and altered plasma cytokine may underlie the difference between those two groups. PMID: 32285715 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 16, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Blood-based markers for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas - what's beyond the horizon?
Authors: Midlöv F, Ansari D, Aronsson L, Andersson R PMID: 32286902 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 16, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Increase in the incidence of alcoholic pancreatitis and alcoholic liver disease in Iceland: impact of per capita alcohol consumption.
Conclusions: Increase per capita alcohol consumption over a 15 year study period was associated with an increase in the incidence of severe alcoholic liver disease and alcohol-related acute pancreatitis in males but not in females. PMID: 32289240 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 16, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Inutility of endoscopic sphincterotomy to prevent pancreatitis after biliary metal stent placement in the patients without pancreatic duct obstruction.
Conclusions: ES prior to MS placement for patients with distal MBO without MPD obstruction does not reduce the incidence of PEP. PMID: 32275454 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 12, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Serological antibodies and surgery in a population-based inception cohort of Crohn's disease patients - the IBSEN study.
Conclusion: Positive ASCA IgA and IgG, and negative pANCA were associated with higher odds for CD-related surgery in univariate analysis. Since disease phenotype changes during the disease course, while serological antibodies are stable, our results support the use of pANCA, ASCA IgA and ASCA IgG as prognostic markers in CD. PMID: 32252542 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 9, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

An international polypectomy practice survey.
Conclusions: This survey found a substantial increase in CSP use during recent years. CSP has become the predominant polypectomy approach for 4‒10 mm colorectal polyps, while HSP remained the predominant approach for larger (10‒20 mm) polyps. Clinical practice patterns are well aligned with recently issued guideline recommendations. PMID: 32267187 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 9, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

S-POEM in treatment of achalasia and esophageal epiphrenic diverticula - single center experience.
Authors: Demeter M, Ďuriček M, Vorčák M, Hyrdel R, Kunda R, Bánovčin P Abstract Background: Standard treatment for esophageal epiphrenic diverticula associated with achalasia includes surgical diverticulectomy, myotomy and anterior fundoplication. However, several case reports published recently suggest that endoscopic approach using per oral endoscopic myotomy is a safe and effective alternative.Methods: This is a retrospective review of a single center case series of patients with achalasia and epiphrenic diverticula. During the treatment, the POEM guided on the opposite site of the diverticular...
Source: Scandinavian Journal of Gastroenterology - April 8, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Simplify to improve in capsule endoscopy - TOP 100 is a swift and reliable evaluation tool for the small bowel inflammatory activity in Crohn's disease.
Authors: Freitas M, Arieira C, Carvalho PB, Rosa B, Moreira MJ, Cotter J Abstract Background: Capsule endoscopy is a widely recognized method to study the small bowel, including in patients with Crohn's disease (CD). The Lewis score (LS) is a valuable tool in this setting, able to assess inflammatory activity. TOP100, a new software tool of the RAPID Reader®, emerged to assist in the time-consuming capsule reading process, by automatically selecting 100 images that will most likely contain abnormalities.Aim: Evaluate the agreement between TOP100 and classic reading (CR) in determining LS in the setting of CD.Me...
Source: Scandinavian Journal of Gastroenterology - April 3, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Pathophysiological-based treatments of complications of cirrhosis.
Authors: Møller S, Kimer N, Barløse M, Bendtsen F Abstract Detailed knowledge and understanding of the pathophysiological mechanisms and changes in hepatic and splanchnic function leading to the development of haemodynamic changes and portal hypertension in patients with cirrhosis are essential since it guides the search for targets to ameliorate liver-related abnormalities. Recent research has focused on the gut-liver axis, changes in intestinal permeability, translocation of bacterial products, and inflammation as important drivers of haemodynamic alterations and thereby targets for treatment. Addit...
Source: Scandinavian Journal of Gastroenterology - April 3, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Abstinence from alcohol and alcohol rehabilitation therapy in alcoholic liver disease: a population-based study.
Conclusion: Abstinence from alcohol following AC/AH diagnosis was achieved in 39% of patients. Abstinence was not related to increased survival for alcoholic liver disease patients at one-year, which might partly indicate that this might be a marker that some patients were 'too sick to drink'. AC and AH patients who survived one year and remained abstinent had a favorable long-term prognosis. PMID: 32233877 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 3, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The incidence and long-term outcomes of esophageal perforations in Finland between 1996 and 2017 - a national registry-based analysis of 1106 esophageal perforations showing high early and late mortality rates and better outcomes in patients treated at high-volume centers.
Conclusion: There is a slightly increasing trend in the occurrence of esophageal perforations. Contemporary treatment is less invasive with similar results. Patients treated in high-volume hospitals have better prognosis. PMID: 32233883 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 3, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The impact of body weight on dysplasia of colonic adenomas: a case-control study.
CONCLUSIONS: Our findings support the protective effect a normal weight against advanced adenomas. Reduction of BMI value should be pursued in healthy programs. PMID: 32233893 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 3, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Use of endoscopic assessment of gastric atrophy for gastric cancer risk stratification to reduce the need for gastric mapping.
Conclusions: Gastric cancer risk assessment using endoscopic or histologic methods provided similar results such that the absence or a mild grade of endoscopic gastric atrophy would preclude the need for histologic mapping. PMID: 32223458 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 2, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Risk factors for short recurrence-free survival after resection of pancreatic neuroendocrine tumor (PanNET) liver metastases: which patients should undergo resection?
Conclusions: These findings indicate that good candidates for resection of metastatic tumors of PanNETs could be patients with low Ki67 tumors and a small number of metastatic tumors. PMID: 32223573 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 2, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Percutaneous endoscopic gastrostomy: dealing with the issue of dislodgement.
Authors: Magalhães RS, Cúrdia Gonçalves T, Sousa-Pinto B, Rosa B, Marinho C, Cotter J Abstract Introduction: Percutaneous Endoscopic Gastrostomy (PEG) is accepted as an efficient method to provide long-term enteral nutrition. PEG accidental dislodgement (device exteriorization confirmed by expert evaluation) rate is high and can lead to major morbidity.Objective: To identify independent risk factors for PEG accidental dislodgement.Methods: Retrospective, single-center study, including consecutive patients submitted to PEG procedure, for 38 consecutive months. Every patient had 12 months ...
Source: Scandinavian Journal of Gastroenterology - March 24, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Elective surgery should be considered after successful conservative treatment of recurrent diverticular abscesses.
Conclusion: The majority of patients with diverticular abscesses had recurrences with repeated admissions regardless of abscess location. An unexpectedly high proportion of patients required surgical intervention during the follow-up period. A liberal approach regarding elective surgery for patients with recurrent diverticulitis abscesses who tolerate surgery seems justified. PMID: 32202966 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - March 24, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Health-related quality of life before and after liver transplantation in patients with primary sclerosing cholangitis.
Conclusions: HRQoL does not decrease markedly after LTx in the premalignant PSC group, and this group does cope better than the symptomatic PSC group. After LTx, mean HRQoL of the premalignant group stays close to that of the age- and gender-standardized general population. PMID: 32191135 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - March 20, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Prognostic relevance of programmed death-ligand 1 expression and microsatellite status in small bowel adenocarcinoma.
Conclusion: Although PD-L1 expression is associated with prolonged survival, it was not identified as an independent prognostic marker. Microsatellite status did not influence long-term survival. PMID: 32191146 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - March 20, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research