The effectiveness of using an abdominal binder during colonoscopy: a randomized, double-blind, sham-controlled trial
In this study, the effectiveness of using an abdominal binder (AB) during colonoscopy on procedure time and colonoscopy outcomes was investigated.METHODS: We conducted a parallel randomized double-blind sham-device-controlled study of patients who underwent elective outpatient colonoscopy between 1 May 2020, and 31 August 2020. Participants were randomly assigned to AB (n = 173) and sham binder (SB) (n = 173) groups. The primary outcome was CIT. Secondary outcomes were the need for auxiliary maneuvers, the cecum intubation length (CIL) of the colonoscope, visual analog scale (VAS) score, narcotic analgesic dose, and colono...
Source: Scandinavian Journal of Gastroenterology - June 22, 2021 Category: Gastroenterology Authors: Beslen Goksoy Mevlut Kiyak Source Type: research

Inflammatory bowel disease in South-Eastern Norway III (IBSEN III): a new population-based inception cohort study from South-Eastern Norway
CONCLUSION: We have included patients in a comprehensive population-based IBD cohort from a catchment population of 2.95 million, and a unique biobank with materials from newly diagnosed and treatment-naïve IBD patients and symptomatic non-IBD controls. We believe this cohort will add important knowledge about IBD in the years to come.PMID:34154494 | DOI:10.1080/00365521.2021.1922746 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 22, 2021 Category: Gastroenterology Authors: Vendel A Kristensen Randi Opheim G øri Perminow Gert Huppertz-Hauss Trond Espen Detlie Charlotte Lund Svend Andersen Bj ørn C Olsen Ingunn Johansen Asle W Medhus Simen Vatn Stephan Brackmann Christine Olbj ørn Jon Rove Magne Henriksen Emma Elisabeth L Source Type: research

Benefit of measuring vedolizumab concentrations in inflammatory bowel disease patients in a real-world setting
CONCLUSIONS: During the maintenance of VDZ therapy, the majority of VDZ TCs were within the suggested range. Measurement of VDZ TC did not lead to any treatment changes in two-thirds of patients. Dose optimization occurred in a quarter of patients and a third of them benefited from it.PMID:34154506 | DOI:10.1080/00365521.2021.1938206 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 22, 2021 Category: Gastroenterology Authors: Sara Kolehmainen Tero Ylisaukko-Oja Jari Jokelainen Mirkka Koivusalo T Sakari Jokiranta Taina Sipponen Source Type: research

The effectiveness of using an abdominal binder during colonoscopy: a randomized, double-blind, sham-controlled trial
In this study, the effectiveness of using an abdominal binder (AB) during colonoscopy on procedure time and colonoscopy outcomes was investigated.METHODS: We conducted a parallel randomized double-blind sham-device-controlled study of patients who underwent elective outpatient colonoscopy between 1 May 2020, and 31 August 2020. Participants were randomly assigned to AB (n = 173) and sham binder (SB) (n = 173) groups. The primary outcome was CIT. Secondary outcomes were the need for auxiliary maneuvers, the cecum intubation length (CIL) of the colonoscope, visual analog scale (VAS) score, narcotic analgesic dose, and colono...
Source: Scandinavian Journal of Gastroenterology - June 22, 2021 Category: Gastroenterology Authors: Beslen Goksoy Mevlut Kiyak Source Type: research

Inflammatory bowel disease in South-Eastern Norway III (IBSEN III): a new population-based inception cohort study from South-Eastern Norway
CONCLUSION: We have included patients in a comprehensive population-based IBD cohort from a catchment population of 2.95 million, and a unique biobank with materials from newly diagnosed and treatment-naïve IBD patients and symptomatic non-IBD controls. We believe this cohort will add important knowledge about IBD in the years to come.PMID:34154494 | DOI:10.1080/00365521.2021.1922746 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 22, 2021 Category: Gastroenterology Authors: Vendel A Kristensen Randi Opheim G øri Perminow Gert Huppertz-Hauss Trond Espen Detlie Charlotte Lund Svend Andersen Bj ørn C Olsen Ingunn Johansen Asle W Medhus Simen Vatn Stephan Brackmann Christine Olbj ørn Jon Rove Magne Henriksen Emma Elisabeth L Source Type: research

Benefit of measuring vedolizumab concentrations in inflammatory bowel disease patients in a real-world setting
CONCLUSIONS: During the maintenance of VDZ therapy, the majority of VDZ TCs were within the suggested range. Measurement of VDZ TC did not lead to any treatment changes in two-thirds of patients. Dose optimization occurred in a quarter of patients and a third of them benefited from it.PMID:34154506 | DOI:10.1080/00365521.2021.1938206 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 22, 2021 Category: Gastroenterology Authors: Sara Kolehmainen Tero Ylisaukko-Oja Jari Jokelainen Mirkka Koivusalo T Sakari Jokiranta Taina Sipponen Source Type: research

ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma
CONCLUSIONS: Our work suggests that ROBO2 inhibits tumor progression in PDAC and may serve as a predictive biomarker and therapeutic target in PDAC.PMID:34148491 | DOI:10.1080/00365521.2021.1930144 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 21, 2021 Category: Gastroenterology Authors: Cheng Ding Yatong Li Shunda Wang Cheng Xing Lixin Chen Hanyu Zhang Yizhi Wang Menghua Dai Source Type: research

Screening, clinical features and prognostic analysis of liver cirrhosis-related hepatocellular carcinoma
Scand J Gastroenterol. 2021 Jun 19:1-7. doi: 10.1080/00365521.2021.1938208. Online ahead of print.ABSTRACTOBJECTIVE: To explore the impact of the screening interval and methods on cirrhosis-related hepatocellular carcinoma (HCC) detection and to analyse the clinical features and prognosis of HCC.MATERIALS AND METHODS: We recruited 3000 patients diagnosed with liver cirrhosis, who had been treated at the First Affiliated Hospital of Anhui Medical University from January 2016 to January 2020. The time of admission was divided into 3- (group A, 539 cases), 6- (group B, 1012 cases), and 12-month screening groups (group C, 1449...
Source: Scandinavian Journal of Gastroenterology - June 21, 2021 Category: Gastroenterology Authors: Zhengwei Zha Wenyue Wu Qianqian Zhang Xi Wang Xuecan Mei Yi Xiang Derun Kong Source Type: research

ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma
CONCLUSIONS: Our work suggests that ROBO2 inhibits tumor progression in PDAC and may serve as a predictive biomarker and therapeutic target in PDAC.PMID:34148491 | DOI:10.1080/00365521.2021.1930144 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 21, 2021 Category: Gastroenterology Authors: Cheng Ding Yatong Li Shunda Wang Cheng Xing Lixin Chen Hanyu Zhang Yizhi Wang Menghua Dai Source Type: research

Screening, clinical features and prognostic analysis of liver cirrhosis-related hepatocellular carcinoma
Scand J Gastroenterol. 2021 Jun 19:1-7. doi: 10.1080/00365521.2021.1938208. Online ahead of print.ABSTRACTOBJECTIVE: To explore the impact of the screening interval and methods on cirrhosis-related hepatocellular carcinoma (HCC) detection and to analyse the clinical features and prognosis of HCC.MATERIALS AND METHODS: We recruited 3000 patients diagnosed with liver cirrhosis, who had been treated at the First Affiliated Hospital of Anhui Medical University from January 2016 to January 2020. The time of admission was divided into 3- (group A, 539 cases), 6- (group B, 1012 cases), and 12-month screening groups (group C, 1449...
Source: Scandinavian Journal of Gastroenterology - June 21, 2021 Category: Gastroenterology Authors: Zhengwei Zha Wenyue Wu Qianqian Zhang Xi Wang Xuecan Mei Yi Xiang Derun Kong Source Type: research

Letter to the editor regarding 'the role of female endoscopists: are women gastroenterologists better at obtaining biopsies for celiac disease than men'?
Scand J Gastroenterol. 2021 Jun 7:1-2. doi: 10.1080/00365521.2021.1934726. Online ahead of print.NO ABSTRACTPMID:34098812 | DOI:10.1080/00365521.2021.1934726 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 8, 2021 Category: Gastroenterology Authors: Matthew A Taylor David S Sanders Source Type: research

Hybrid resection of large colorectal adenomas combining EMR and FTRD
CONCLUSIONS: Hybrid EMR-EFTR in the colorectum seems to be a safe and effective technique for large non-lifting lesions with positive lifting signs in the margins. Further prospective evaluation of efficacy, safety and long-term outcome of this hybrid technique is necessary.PMID:34078211 | DOI:10.1080/00365521.2021.1933583 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 3, 2021 Category: Gastroenterology Authors: Maximilian Bauermeister Matthias Mende Steffen Hornoff Siegbert Faiss Source Type: research

Presence of interferon- λ 4, male gender, absent/mild steatosis and low viral load augment antibody levels to hepatitis C virus
Scand J Gastroenterol. 2021 Jun 2:1-6. doi: 10.1080/00365521.2021.1922750. Online ahead of print.ABSTRACTOBJECTIVES: Despite recombinant interferon-λ 4 (IFN-λ4) demonstrating anti-viral activity in vitro and the ancestral functional gene (IFNL4) being conserved in all other primates, there has been speculation that IFN-λ4 may be detrimental in humans. In light of recent rekindled interest in humoral immunity, this study aimed at evaluating the impact of baseline characteristics, including IFNL4, on antibody levels to hepatitis C virus (HCV).MATERIALS AND METHODS: Pretreatment sera from 279 well-charact...
Source: Scandinavian Journal of Gastroenterology - June 3, 2021 Category: Gastroenterology Authors: Jesper Waldenstr öm Kristoffer Hellstrand Johan Westin Staffan Nilsson Peer Christensen Martti F ärkkilä Kristine M ørch Nina Langeland Gunnar Norkrans Martin Lagging Source Type: research

Hybrid resection of large colorectal adenomas combining EMR and FTRD
CONCLUSIONS: Hybrid EMR-EFTR in the colorectum seems to be a safe and effective technique for large non-lifting lesions with positive lifting signs in the margins. Further prospective evaluation of efficacy, safety and long-term outcome of this hybrid technique is necessary.PMID:34078211 | DOI:10.1080/00365521.2021.1933583 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 3, 2021 Category: Gastroenterology Authors: Maximilian Bauermeister Matthias Mende Steffen Hornoff Siegbert Faiss Source Type: research

Presence of interferon- λ 4, male gender, absent/mild steatosis and low viral load augment antibody levels to hepatitis C virus
Scand J Gastroenterol. 2021 Jun 2:1-6. doi: 10.1080/00365521.2021.1922750. Online ahead of print.ABSTRACTOBJECTIVES: Despite recombinant interferon-λ 4 (IFN-λ4) demonstrating anti-viral activity in vitro and the ancestral functional gene (IFNL4) being conserved in all other primates, there has been speculation that IFN-λ4 may be detrimental in humans. In light of recent rekindled interest in humoral immunity, this study aimed at evaluating the impact of baseline characteristics, including IFNL4, on antibody levels to hepatitis C virus (HCV).MATERIALS AND METHODS: Pretreatment sera from 279 well-charact...
Source: Scandinavian Journal of Gastroenterology - June 3, 2021 Category: Gastroenterology Authors: Jesper Waldenstr öm Kristoffer Hellstrand Johan Westin Staffan Nilsson Peer Christensen Martti F ärkkilä Kristine M ørch Nina Langeland Gunnar Norkrans Martin Lagging Source Type: research

Hybrid resection of large colorectal adenomas combining EMR and FTRD
CONCLUSIONS: Hybrid EMR-EFTR in the colorectum seems to be a safe and effective technique for large non-lifting lesions with positive lifting signs in the margins. Further prospective evaluation of efficacy, safety and long-term outcome of this hybrid technique is necessary.PMID:34078211 | DOI:10.1080/00365521.2021.1933583 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 3, 2021 Category: Gastroenterology Authors: Maximilian Bauermeister Matthias Mende Steffen Hornoff Siegbert Faiss Source Type: research

Presence of interferon- λ 4, male gender, absent/mild steatosis and low viral load augment antibody levels to hepatitis C virus
Scand J Gastroenterol. 2021 Jun 2:1-6. doi: 10.1080/00365521.2021.1922750. Online ahead of print.ABSTRACTOBJECTIVES: Despite recombinant interferon-λ 4 (IFN-λ4) demonstrating anti-viral activity in vitro and the ancestral functional gene (IFNL4) being conserved in all other primates, there has been speculation that IFN-λ4 may be detrimental in humans. In light of recent rekindled interest in humoral immunity, this study aimed at evaluating the impact of baseline characteristics, including IFNL4, on antibody levels to hepatitis C virus (HCV).MATERIALS AND METHODS: Pretreatment sera from 279 well-charact...
Source: Scandinavian Journal of Gastroenterology - June 3, 2021 Category: Gastroenterology Authors: Jesper Waldenstr öm Kristoffer Hellstrand Johan Westin Staffan Nilsson Peer Christensen Martti F ärkkilä Kristine M ørch Nina Langeland Gunnar Norkrans Martin Lagging Source Type: research

Hybrid resection of large colorectal adenomas combining EMR and FTRD
CONCLUSIONS: Hybrid EMR-EFTR in the colorectum seems to be a safe and effective technique for large non-lifting lesions with positive lifting signs in the margins. Further prospective evaluation of efficacy, safety and long-term outcome of this hybrid technique is necessary.PMID:34078211 | DOI:10.1080/00365521.2021.1933583 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 3, 2021 Category: Gastroenterology Authors: Maximilian Bauermeister Matthias Mende Steffen Hornoff Siegbert Faiss Source Type: research

Presence of interferon- λ 4, male gender, absent/mild steatosis and low viral load augment antibody levels to hepatitis C virus
Scand J Gastroenterol. 2021 Jun 2:1-6. doi: 10.1080/00365521.2021.1922750. Online ahead of print.ABSTRACTOBJECTIVES: Despite recombinant interferon-λ 4 (IFN-λ4) demonstrating anti-viral activity in vitro and the ancestral functional gene (IFNL4) being conserved in all other primates, there has been speculation that IFN-λ4 may be detrimental in humans. In light of recent rekindled interest in humoral immunity, this study aimed at evaluating the impact of baseline characteristics, including IFNL4, on antibody levels to hepatitis C virus (HCV).MATERIALS AND METHODS: Pretreatment sera from 279 well-charact...
Source: Scandinavian Journal of Gastroenterology - June 3, 2021 Category: Gastroenterology Authors: Jesper Waldenstr öm Kristoffer Hellstrand Johan Westin Staffan Nilsson Peer Christensen Martti F ärkkilä Kristine M ørch Nina Langeland Gunnar Norkrans Martin Lagging Source Type: research

How dyspepsia, gastroesophageal reflux symptoms, and overlapping symptoms affect quality of life, use of health care, and medication - a long-term population based cohort study
CONCLUSIONS: Overlapping symptoms was associated with lower quality of life scores and substantial use of health-care resources. Having solely GERS affected quality of life and health care use least.PMID:34062084 | DOI:10.1080/00365521.2021.1929448 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 1, 2021 Category: Gastroenterology Authors: Katrine Mie Klausen Maria Bomme H øgh Marc David Ove B Schaffalitzky de Muckadell Jane M øller Hansen Source Type: research

Prevalence rates of heathy stomach mucosa, chronic non-atrophic and atrophic gastritis in endoscopic biopsies in adults born in Finland in 1890-1977
CONCLUSIONS: Over 70-year period from 1900 onward, the prevalence rate of 'diseased' stomach (CG or AG) decreased and that of 'healthy' (N) stomach increased in birth cohorts over 50%, by rate about 10% over every 10-year period of time. In birth cohorts, CG progressed to AG with aging of the subjects at a rate of about 10% over every 10 years of calendar age.PMID:34056994 | DOI:10.1080/00365521.2021.1929451 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 31, 2021 Category: Gastroenterology Authors: Pentti Sipponen Source Type: research

Irreversible electroporation versus radiofrequency ablation for hepatocellular carcinoma: a single centre propensity-matched comparison
CONCLUSIONS: Whilst IRE remains a relatively novel therapy for HCC cases where standard thermal ablation is contraindicated, the LRFS in our centre is comparable to that of RFA. IRE should therefore be considered as a treatment option in such cases when available before stage-migration to non-curative therapies such as transarterial chemoembolization (TACE).PMID:34057003 | DOI:10.1080/00365521.2021.1930145 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 31, 2021 Category: Gastroenterology Authors: Elliot Freeman Wa Cheung Sapphire Ferdousi Helen Kavnoudias Ammar Majeed William Kemp Stuart K Roberts Source Type: research

High disease burden in treated celiac patients - a web-based survey
Scand J Gastroenterol. 2021 May 30:1-7. doi: 10.1080/00365521.2021.1930146. Online ahead of print.ABSTRACTBACKGROUND: Strict adherence to a gluten-free diet usually leads to clinical and histological remission in celiac disease. Few studies have investigated the prevalence of persistent symptoms in a celiac population. We aimed to study the impact of gastrointestinal symptoms on general health in a large number of treated celiac patients, and describe the prevalence of persistent gastrointestinal symptoms and investigate associated factors.METHODS: Adults with celiac disease filled out background questions, the Celiac Symp...
Source: Scandinavian Journal of Gastroenterology - May 31, 2021 Category: Gastroenterology Authors: Frida van Megen Gry I Skodje Marianne Stendahl Marit B Veier ød Knut E A Lundin Christine Henriksen Source Type: research

Diagnostic and therapeutic challenge of unclassifiable enteropathies with increased intraepithelial CD103 < sup > + < /sup > CD8 < sup > + < /sup > T lymphocytes: a single center case series
CONCLUSIONS: We report a patient population with 'difficult-to-classify' enteropathies characterized by various degrees of villous atrophy and strongly increased intraepithelial CD103+ CD8+ T cells in the small intestine which harbor an increased risk for T-cell lymphoproliferative disorders. Clinical course, histology, and response to immunosuppressive therapy all suggest an autoimmune pathogenesis.PMID:34057863 | DOI:10.1080/00365521.2021.1931958 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 31, 2021 Category: Gastroenterology Authors: Christina Hartl J ürgen Finke Peter Hasselblatt Wolfgang Kreisel Annette Schmitt-Graeff Source Type: research

Prevalence rates of heathy stomach mucosa, chronic non-atrophic and atrophic gastritis in endoscopic biopsies in adults born in Finland in 1890-1977
CONCLUSIONS: Over 70-year period from 1900 onward, the prevalence rate of 'diseased' stomach (CG or AG) decreased and that of 'healthy' (N) stomach increased in birth cohorts over 50%, by rate about 10% over every 10-year period of time. In birth cohorts, CG progressed to AG with aging of the subjects at a rate of about 10% over every 10 years of calendar age.PMID:34056994 | DOI:10.1080/00365521.2021.1929451 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 31, 2021 Category: Gastroenterology Authors: Pentti Sipponen Source Type: research

Irreversible electroporation versus radiofrequency ablation for hepatocellular carcinoma: a single centre propensity-matched comparison
CONCLUSIONS: Whilst IRE remains a relatively novel therapy for HCC cases where standard thermal ablation is contraindicated, the LRFS in our centre is comparable to that of RFA. IRE should therefore be considered as a treatment option in such cases when available before stage-migration to non-curative therapies such as transarterial chemoembolization (TACE).PMID:34057003 | DOI:10.1080/00365521.2021.1930145 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 31, 2021 Category: Gastroenterology Authors: Elliot Freeman Wa Cheung Sapphire Ferdousi Helen Kavnoudias Ammar Majeed William Kemp Stuart K Roberts Source Type: research

High disease burden in treated celiac patients - a web-based survey
Scand J Gastroenterol. 2021 May 30:1-7. doi: 10.1080/00365521.2021.1930146. Online ahead of print.ABSTRACTBACKGROUND: Strict adherence to a gluten-free diet usually leads to clinical and histological remission in celiac disease. Few studies have investigated the prevalence of persistent symptoms in a celiac population. We aimed to study the impact of gastrointestinal symptoms on general health in a large number of treated celiac patients, and describe the prevalence of persistent gastrointestinal symptoms and investigate associated factors.METHODS: Adults with celiac disease filled out background questions, the Celiac Symp...
Source: Scandinavian Journal of Gastroenterology - May 31, 2021 Category: Gastroenterology Authors: Frida van Megen Gry I Skodje Marianne Stendahl Marit B Veier ød Knut E A Lundin Christine Henriksen Source Type: research

Diagnostic and therapeutic challenge of unclassifiable enteropathies with increased intraepithelial CD103 < sup > + < /sup > CD8 < sup > + < /sup > T lymphocytes: a single center case series
CONCLUSIONS: We report a patient population with 'difficult-to-classify' enteropathies characterized by various degrees of villous atrophy and strongly increased intraepithelial CD103+ CD8+ T cells in the small intestine which harbor an increased risk for T-cell lymphoproliferative disorders. Clinical course, histology, and response to immunosuppressive therapy all suggest an autoimmune pathogenesis.PMID:34057863 | DOI:10.1080/00365521.2021.1931958 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 31, 2021 Category: Gastroenterology Authors: Christina Hartl J ürgen Finke Peter Hasselblatt Wolfgang Kreisel Annette Schmitt-Graeff Source Type: research

Virtual chromoendoscopy with iSCAN as an alternative method to dye-spray chromoendoscopy for dysplasia detection in long-standing colonic inflammatory bowel disease: a case-control study
Scand J Gastroenterol. 2021 May 27:1-9. doi: 10.1080/00365521.2021.1925339. Online ahead of print.ABSTRACTOBJECTIVE: Patients with long-standing colonic inflammatory bowel disease (cIBD) are at increased risk of developing colorectal cancer (CRC). Dye-spray chromoendoscopy (DCE) with targeted biopsies is the preferred technique for surveillance of dysplasia. Virtual chromoendoscopy (VCE) are arising to improve detection rates and adherence to surveillance guidelines, although its role is not yet well defined. The purpose of this study is to assess the effectiveness of VCE with iSCAN as an alternative method for dysplasia d...
Source: Scandinavian Journal of Gastroenterology - May 27, 2021 Category: Gastroenterology Authors: Antonio L ópez-Serrano Mar ía J Suárez Paula Bes ó Angela Algarra Patricia Latorre Mar ía M Barrachina Jos é M Paredes Source Type: research

Pseudoachalasia: a diagnostic challenge. When to consider and how to manage?
Scand J Gastroenterol. 2021 May 27:1-6. doi: 10.1080/00365521.2021.1925957. Online ahead of print.ABSTRACTPseudoachalasia accounts for up to 4% of patients who present with achalasia-like picture and most often relates to occult malignancy at the cardia or gastroesophageal junction. Thus, any delay in diagnosis might lead to more advanced disease and less chance for curative therapy, not to mention the risk of serious complications resulting from the treatment of supposed achalasia instead of the true underlying cause. The entity should be suspected in patients with advanced age of onset, a shorter duration of symptoms, pr...
Source: Scandinavian Journal of Gastroenterology - May 27, 2021 Category: Gastroenterology Authors: Sara N Haj Ali Nam Q Nguyen Awni T Abu Sneineh Source Type: research

Virtual chromoendoscopy with iSCAN as an alternative method to dye-spray chromoendoscopy for dysplasia detection in long-standing colonic inflammatory bowel disease: a case-control study
Scand J Gastroenterol. 2021 May 27:1-9. doi: 10.1080/00365521.2021.1925339. Online ahead of print.ABSTRACTOBJECTIVE: Patients with long-standing colonic inflammatory bowel disease (cIBD) are at increased risk of developing colorectal cancer (CRC). Dye-spray chromoendoscopy (DCE) with targeted biopsies is the preferred technique for surveillance of dysplasia. Virtual chromoendoscopy (VCE) are arising to improve detection rates and adherence to surveillance guidelines, although its role is not yet well defined. The purpose of this study is to assess the effectiveness of VCE with iSCAN as an alternative method for dysplasia d...
Source: Scandinavian Journal of Gastroenterology - May 27, 2021 Category: Gastroenterology Authors: Antonio L ópez-Serrano Mar ía J Suárez Paula Bes ó Angela Algarra Patricia Latorre Mar ía M Barrachina Jos é M Paredes Source Type: research

Pseudoachalasia: a diagnostic challenge. When to consider and how to manage?
Scand J Gastroenterol. 2021 May 27:1-6. doi: 10.1080/00365521.2021.1925957. Online ahead of print.ABSTRACTPseudoachalasia accounts for up to 4% of patients who present with achalasia-like picture and most often relates to occult malignancy at the cardia or gastroesophageal junction. Thus, any delay in diagnosis might lead to more advanced disease and less chance for curative therapy, not to mention the risk of serious complications resulting from the treatment of supposed achalasia instead of the true underlying cause. The entity should be suspected in patients with advanced age of onset, a shorter duration of symptoms, pr...
Source: Scandinavian Journal of Gastroenterology - May 27, 2021 Category: Gastroenterology Authors: Sara N Haj Ali Nam Q Nguyen Awni T Abu Sneineh Source Type: research

Virtual chromoendoscopy with iSCAN as an alternative method to dye-spray chromoendoscopy for dysplasia detection in long-standing colonic inflammatory bowel disease: a case-control study
Scand J Gastroenterol. 2021 May 27:1-9. doi: 10.1080/00365521.2021.1925339. Online ahead of print.ABSTRACTOBJECTIVE: Patients with long-standing colonic inflammatory bowel disease (cIBD) are at increased risk of developing colorectal cancer (CRC). Dye-spray chromoendoscopy (DCE) with targeted biopsies is the preferred technique for surveillance of dysplasia. Virtual chromoendoscopy (VCE) are arising to improve detection rates and adherence to surveillance guidelines, although its role is not yet well defined. The purpose of this study is to assess the effectiveness of VCE with iSCAN as an alternative method for dysplasia d...
Source: Scandinavian Journal of Gastroenterology - May 27, 2021 Category: Gastroenterology Authors: Antonio L ópez-Serrano Mar ía J Suárez Paula Bes ó Angela Algarra Patricia Latorre Mar ía M Barrachina Jos é M Paredes Source Type: research

Pseudoachalasia: a diagnostic challenge. When to consider and how to manage?
Scand J Gastroenterol. 2021 May 27:1-6. doi: 10.1080/00365521.2021.1925957. Online ahead of print.ABSTRACTPseudoachalasia accounts for up to 4% of patients who present with achalasia-like picture and most often relates to occult malignancy at the cardia or gastroesophageal junction. Thus, any delay in diagnosis might lead to more advanced disease and less chance for curative therapy, not to mention the risk of serious complications resulting from the treatment of supposed achalasia instead of the true underlying cause. The entity should be suspected in patients with advanced age of onset, a shorter duration of symptoms, pr...
Source: Scandinavian Journal of Gastroenterology - May 27, 2021 Category: Gastroenterology Authors: Sara N Haj Ali Nam Q Nguyen Awni T Abu Sneineh Source Type: research

Virtual chromoendoscopy with iSCAN as an alternative method to dye-spray chromoendoscopy for dysplasia detection in long-standing colonic inflammatory bowel disease: a case-control study
Scand J Gastroenterol. 2021 May 27:1-9. doi: 10.1080/00365521.2021.1925339. Online ahead of print.ABSTRACTOBJECTIVE: Patients with long-standing colonic inflammatory bowel disease (cIBD) are at increased risk of developing colorectal cancer (CRC). Dye-spray chromoendoscopy (DCE) with targeted biopsies is the preferred technique for surveillance of dysplasia. Virtual chromoendoscopy (VCE) are arising to improve detection rates and adherence to surveillance guidelines, although its role is not yet well defined. The purpose of this study is to assess the effectiveness of VCE with iSCAN as an alternative method for dysplasia d...
Source: Scandinavian Journal of Gastroenterology - May 27, 2021 Category: Gastroenterology Authors: Antonio L ópez-Serrano Mar ía J Suárez Paula Bes ó Angela Algarra Patricia Latorre Mar ía M Barrachina Jos é M Paredes Source Type: research

Pseudoachalasia: a diagnostic challenge. When to consider and how to manage?
Scand J Gastroenterol. 2021 May 27:1-6. doi: 10.1080/00365521.2021.1925957. Online ahead of print.ABSTRACTPseudoachalasia accounts for up to 4% of patients who present with achalasia-like picture and most often relates to occult malignancy at the cardia or gastroesophageal junction. Thus, any delay in diagnosis might lead to more advanced disease and less chance for curative therapy, not to mention the risk of serious complications resulting from the treatment of supposed achalasia instead of the true underlying cause. The entity should be suspected in patients with advanced age of onset, a shorter duration of symptoms, pr...
Source: Scandinavian Journal of Gastroenterology - May 27, 2021 Category: Gastroenterology Authors: Sara N Haj Ali Nam Q Nguyen Awni T Abu Sneineh Source Type: research

Absence of interferon- λ 4 enhances spontaneous clearance of acute hepatitis C virus genotypes 1-3 infection
This study aimed at investigating the impact of IFNL4 on acute HCV genotype 2 or 3 infections, and whether ITPase activity influenced outcome.MATERIALS AND METHODS: Two hundred and seven people who injected drugs (PWID) with documented anti-HCV seroconversion, and 57 PWID with reinfection with HCV were analyzed regarding IFNL4 (rs368234815 and rs12979860) and ITPA (rs1127354 and rs7270101), and longitudinally followed regarding HCV RNA.RESULTS: The spontaneous clearance of HCV infection in anti-HCV seronegative PWID was enhanced when IFN-λ4 was absent (44% vs. 20% for IFNL4 TT/TTrs1368234815 and ΔGrs1368234815 respectively, p
Source: Scandinavian Journal of Gastroenterology - May 26, 2021 Category: Gastroenterology Authors: Jesper Waldenstr öm Martin K åberg Marianne Alanko Blom é Anders Widell Per Bj örkman Staffan Nilsson Anders Hammarberg Ola Weiland Kristina Nystr öm Martin Lagging Source Type: research

IPMN of the pancreas - does histological subtyping allow for improved stratification and follow-up?
Scand J Gastroenterol. 2021 May 25:1-3. doi: 10.1080/00365521.2021.1922745. Online ahead of print.NO ABSTRACTPMID:34033516 | DOI:10.1080/00365521.2021.1922745 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 25, 2021 Category: Gastroenterology Authors: Daniel Ansari Jacob Amini Maja Edman Roland Andersson Source Type: research

NAFLD cirrhosis in Sweden
Scand J Gastroenterol. 2021 May 25:1-2. doi: 10.1080/00365521.2021.1929449. Online ahead of print.NO ABSTRACTPMID:34033517 | DOI:10.1080/00365521.2021.1929449 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 25, 2021 Category: Gastroenterology Authors: Juan Vaz Source Type: research