Efficacy and safety of tranexamic acid in acute upper gastrointestinal bleeding: meta-analysis of randomised controlled trials.
CONCLUSIONS: Tranexamic acid does not improve outcomes in UGIB and may increase the risk of venous thromboembolic events. PMID: 33112175 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - October 30, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The prognostic value of postoperative circulating cell-free DNA in operable hepatocellular carcinoma.
This study enrolled 82 HCC patients from January 2018 to June 2019. All patients underwent liver surgery and were pathologically diagnosed with HCC. Postoperative blood samples were collected from each patient. A fluorometric dsDNA assay was used to measure the concentration of cfDNA. We explore the correlation between cfDNA and recurrence. Kaplan-Meier's curves were used to evaluate the recurrence-free survival (RFS). Univariate and multivariate Cox regression analyses were used for assessing the relative clinical variables in predicting recurrence. RESULTS: Of the 82 HCC patients, 72 (87%) patients are male and the a...
Source: Scandinavian Journal of Gastroenterology - October 30, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

No association between COVID-19 related liver injury and the course of disease: a retrospective study.
Authors: Sikkema BJB, Sint Nicolaas JJ, van Wijngaarden PP Abstract OBJECTIVE: Several studies have reported on liver injury during COVID-19. However, the definition and timing of liver injury is different among the published articles. The aim of the present study is to evaluate whether COVID-19 related liver injury at the time of first presentation is associated with the course of the disease. METHODS: We conducted a single center retrospective study at Amphia Hospital in Breda, The Netherlands, from February 1 through April 30, 2020. Patients with reverse transcription polymerase chain reaction confirmed COVI...
Source: Scandinavian Journal of Gastroenterology - October 30, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Rapid weight gain in infliximab treated Crohn's disease patients is sustained over time: real-life data over 12 months.
Authors: Lepp J, Höög C, Forsell A, Fyrhake U, Lördal M, Almer S Abstract BACKGROUND: Infliximab (IFX) is used in active Crohn's disease for induction and maintenance of remission. There are scanty data on weight gain in IBD-patients under anti-TNF treatment. We investigated changes in weight and blood chemistry in anti-TNF-naïve Crohn's disease patients during their first course of IFX. METHODS: Retrospective analysis of 110 patients (77 men, 33 women) aged 34 years (range 14-73), 54 with luminal and 56 with fistulising disease, given at least 3 infusions of IFX (range 3-11). Data re...
Source: Scandinavian Journal of Gastroenterology - October 29, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

TERT promoter mutated circulating tumor DNA as a biomarker for prognosis in hepatocellular carcinoma.
Authors: Oversoe SK, Clement MS, Pedersen MH, Weber B, Aagaard NK, Villadsen GE, Grønbæk H, Hamilton-Dutoit SJ, Sorensen BS, Kelsen J Abstract BACKGROUND AND AIMS: Plasma circulating tumor DNA (ctDNA) with tumor-specific mutations is an attractive biomarker. The telomerase reverse transcriptase (TERT) C228T promoter mutation is the most prevalent tumor-associated mutation in hepatocellular carcinoma (HCC). We evaluated the presence and prognostic value of the TERT C228T mutation in plasma and tissue in a Danish HCC cohort. METHODS: We analyzed ctDNA from 95 HCC patients and 45 liver cirrhotic patie...
Source: Scandinavian Journal of Gastroenterology - October 27, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Performance of digital single-operator cholangiopancreatoscope for biliopancreatic diseases in real life: results from a prospective multicenter study.
CONCLUSIONS: POCP was an effective, safe and easy-to-use tool in routine clinical practice for the management of complex diagnostic and therapeutic biliary and pancreatic diseases (NCT03190343). PMID: 33095075 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - October 25, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Lactose after Roux-en-Y gastric bypass for morbid obesity, is it a problem?
Authors: Westerink F, Beijderwellen H, Huibregtse IL, De Hoog MLA, De Brauw LM, Brandjes DPM, Gerdes VEA Abstract BACKGROUND: Roux-en-Y gastric bypass (RYGB) can cause multiple food intolerances and gastrointestinal complaints are frequently reported after dairy consumption. We aimed to determine the prevalence of lactose malabsorption and intolerance, and complaints associated with dairy consumption in daily life, before and after RYGB. METHOD: The lactose breath test (LBT) and lactose tolerance test (LTT) was performed in 84 patients awaiting RYGB surgery and 84 patients after surgery. Gastrointestinal sympto...
Source: Scandinavian Journal of Gastroenterology - October 25, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Partial splenic embolization is superior to intravenous somatostatin for decreasing portal pressure in cirrhotic patients: a dynamic self-controlled cohort study.
CONCLUSION: Our study indicates that somatostatin administration does not decrease WHVP within 20 min at clinically recommended doses. While somatostatin did decrease HVPG, this effect was achieved through increased FHVP, providing a possible explanation for its unclear efficacy. In contrast, PSE decreases both the WHVP and the HVPG. PMID: 33076704 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - October 22, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Adenosquamous carcinoma of the digestive system: a literature review.
Authors: Li HS, He T, Yang LL Abstract Adenosquamous carcinoma (ASC), containing both adenocarcinoma and squamous cell carcinoma components, is rare in the digestive system. Limited data is available on ASC of the digestive system (AS-ASC), and the current evidence is available mainly in the form of case reports and case series. We performed a thorough search of the available literature and compiled a review on the epidemiology, histopathology, pathogenesis, clinical manifestations, diagnosis, treatment, and prognosis of AS-ASC. Non-specific clinical and imaging presentations and low diagnostic accuracy of biopsy l...
Source: Scandinavian Journal of Gastroenterology - October 20, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Efficacy and safety profile of calcineurin inhibitor salvage therapy in autoimmune hepatitis.
CONCLUSION: CNI salvage therapy is well tolerated and moderately effective achieving remission in around 50% of AIH who failed standard therapy. PMID: 33070650 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - October 20, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

eHealth: Disease activity measures are related to the faecal gut microbiota in adult patients with ulcerative colitis.
CONCLUSIONS: In patients with UC, results of both methods are associated with disease activity, correlating significantly with Peptostretococcus anaerobius (16S-seq) and with Proteobacteria, Shigella spp. and Escherichia spp. (DNA test). PMID: 33045169 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - October 15, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The problem with cold snare polypectomy of diminutive colorectal polyps.
Authors: Panteris V PMID: 33045171 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - October 15, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Immunohistochemical markers for eosinophilic esophagitis.
CONCLUSIONS: Immunohistochemistry seems to be a promising option not only in clinical recognition, but also in the selection and monitoring of treatment effects. However, these methods have not yet recommended for routine clinical use. PMID: 33032462 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - October 10, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Incidence and characteristics of pancreatic injuries among trauma patients admitted to a Norwegian trauma centre: a population-based cohort study.
CONCLUSIONS: Incidence of pancreatic injuries is low, even among trauma patients with documented abdominal injuries. Most pancreatic injuries occurred in children. Injuries requiring surgery was rare. PMID: 33027601 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - October 9, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Slow-pull technique yields better quality smears: prospective comparison of slow-pull and standard suction techniques of endoscopic ultrasound-guided fine-needle aspiration.
Authors: Bor R, Vasas B, Fábián A, Szűcs M, Füredi Á, Czakó L, Rutka M, Farkas K, Molnár T, Milassin Á, Bálint A, Szántó K, Hamar S, Kaizer L, Tiszlavicz L, Szepes Z Abstract BACKGROUND: Diagnostic accuracy and quality of smears obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) are influenced by characteristics of suction and examined organ. AIMS AND METHODS: Efficiency of EUS-FNA and quality of smears obtained by slow-pull (SP) and standard suction (SS) techniques was prospectively compared in the sampling of pancreati...
Source: Scandinavian Journal of Gastroenterology - October 7, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Rectal neoplasia extending to the dentate line: clinical outcomes of endoscopic submucosal dissection.
CONCLUSIONS: ESD seems to be safe and effective in the treatment of colorectal neoplasia involving the dentate line and can be considered the best therapeutic strategy. PMID: 33016792 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - October 7, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Clinical course of Crohn's disease in a population-based cohort in Uppsala County followed for 10 years.
CONCLUSIONS: In the present study, the clinical course of CD was similar to previous reports during the first year after diagnosis, but the following years were considerably more stable with moderate increase of intestinal damage and totally a low frequency of surgery and no repeated surgery. PMID: 33016802 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - October 7, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Serum vitamin D level is related to disease progression in primary biliary cholangitis.
Authors: Wang Z, Peng C, Wang P, Sui J, Wang Y, Sun G, Liu M Abstract BACKGROUND AND AIM: A nonskeletal role of vitamin D in primary biliary cholangitis (PBC) patients is not yet clear. The purpose of this study is to investigate the serum vitamin D level in patients with PBC and to explore whether serum vitamin D level is related to disease progression. METHODS: The serum levels of 25(OH)D3 were measured in 185 PBC patients and 141 healthy controls. The association with vitamin D levels and disease progression, particularly natural course, was assessed. RESULTS: Serum vitamin D levels were measured in 185 ...
Source: Scandinavian Journal of Gastroenterology - October 7, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Safety and durability of PEG-J: a single-centre experience.
CONCLUSION: PEG-J placement and replacement are safe procedures. Although PEG-J durability is variable an elective procedure might be indicated to reduce urgent replacements. PMID: 33021876 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - October 7, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Comparison of conventional scoring systems versus MAGIC score to predict short-term mortality in patients hospitalized for alcoholic hepatitis.
Authors: Iyer A, Devadas K, Varghese A, Sreesh S Abstract BACKGROUND: Multiple prognostic models are available to predict mortality in alcoholic hepatitis (AH) which are of modest benefit, but the best model remains unexplored. METHODS: This is a retrospective analysis (2012-2015) of AH patients. Conventional prognostic scoring systems viz. Maddrey's Discriminant Function (mDF), Age Bilirubin International Normalized Ratio and Creatinine (ABIC), Glasgow Alcoholic Hepatitis Score (GAHS), and the Model for End-stage Liver Disease score (MELD), were compared with Model for AH to Grade the Severity in an Asian pati...
Source: Scandinavian Journal of Gastroenterology - October 3, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Predictors of insufficient recanalization and portal hypertensive complications after treatment of non-cirrhotic, non-malignant portal vein thrombosis - a population-based study.
We examined treatment outcomes in PVT and aimed to identify predictors of incomplete recanalization and portal hypertensive complications. MATERIALS AND METHODS: This retrospective study comprised patients diagnosed with PVT between 2006 and 2015. Key exclusion criteria were liver cirrhosis, malignancy, and age
Source: Scandinavian Journal of Gastroenterology - September 27, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Validity of administrative codes associated with cirrhosis in Sweden.
CONCLUSIONS: The validity of ICD-10 codes for cirrhosis, oesophageal varices and HCC is high. However, coding for ascites should be combined with a code of chronic liver disease to have an acceptable validity. PMID: 32960654 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 24, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Increased chronic pain in patients with ulcerative colitis is mostly associated to increased disease activity. A cross-sectional case-control study.
Authors: Pettersson N, Kragsbjerg F, Hamrin A, Bergman S, Forsblad-d'Elia H, Karling P Abstract BACKGROUNDS/AIMS: Musculoskeletal symptoms are common in patients with ulcerative colitis (UC), but no study has compared the prevalence of chronic pain to controls from a general population. METHODS: Patients with UC (n = 1164) and controls (n = 3867) were sent questionnaires comprising demography, history of pain, pain localization and UC patients' Patient-Simple Clinical Colitis Activity Index. Chronic regional pain (ChRP) and chronic widespread pain (ChWP) were defined as having pain f...
Source: Scandinavian Journal of Gastroenterology - September 20, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Gender, having a positive FIT and type of hospital are important factors for colonoscopy experience in colorectal cancer screening - findings from the SCREESCO study.
CONCLUSIONS: Although most participants were satisfied with the colonoscopy experience, the study has highlighted areas for improvement. Important factors for colonoscopy experience were gender, randomization group, and type of hospital and therefore crucial to bear in mind when designing screening programs. PMID: 32946700 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 20, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Childhood growth prior to screen-detected celiac disease: prospective follow-up of an at-risk birth cohort.
CONCLUSIONS: In the first 10 years of life, from prospectively collected serial growth measurements, we found no evidence of impaired childhood growth before CD and CDA development as identified through early and periodic screening. PMID: 32941083 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 19, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Gastrointestinal bleeding due to peptic ulcers and erosions - a prospective observational study (BLUE study).
CONCLUSIONS: The incidence of upper gastrointestinal bleeding due to peptic ulcers and erosions was found to be lower than previously demonstrated in comparable studies, but the overall mortality rate was unchanged. The consumption of risk medication was high, and only a few patients had used prophylactic PPIs. Concurrent H. pylori infection was present in only one-third of the patients. CLINICAL TRIAL REGISTRATION: Bleeding Ulcer and Erosions Study 'BLUE Study', ClinicalTrials.gov Identifier. NCT03367897. PMID: 32931710 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 17, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Arterial embolization for endoscopically unmanageable gastrointestinal bleeding remains the first-line therapy whatever the angiographic features.
Authors: Loffroy R, Falvo N, Midulla M, Chevallier O PMID: 32937085 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 17, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Non-surgical treatment of esophageal perforation after pneumatic dilation for achalasia: a case series.
We present four achalasia patients who underwent pneumatic dilatation, complicated by an esophageal perforation. All patients were treated successfully with endoscopic treatment: two patients with Eso-SPONGE® vacuum therapy, in the other two patients, esophageal defects were closed endoscopically using Endoclips. The time between dilatation and detection of the perforation was less than 24 h in all cases. Non-surgical treatment resulted in a relatively short hospital stay, ranging from 5 to 10 days, and an uneventful recovery in all patients. Based on our experience, endoscopic clipping and/or vacuum therapy are...
Source: Scandinavian Journal of Gastroenterology - September 16, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The risks and characteristics of the delayed bleeding after endoscopic submucosal dissection for early gastric carcinoma in cases with anticoagulants.
Authors: Saito H, Igarashi K, Hirasawa D, Okuzono T, Suzuki K, Abe Y, Nawata Y, Tanaka Y, Tanaka I, Unno S, Nishikawa Y, Tsubokura M, Nakahori M, Chonan A, Matsuda T Abstract BACKGROUND: Endoscopic submucosal dissection (ESD) is a minimally invasive treatment for early gastric carcinoma. Vitamin K antagonists and direct oral anticoagulants (DOAC) were reported to increase the risk of delayed bleeding after ESD. However, the evaluation of ESD cases taking anticoagulants is scarce. We analyzed the risk and characteristics of delayed bleeding after gastric ESD in patients on anticoagulants. METHODS: We performed a...
Source: Scandinavian Journal of Gastroenterology - September 16, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

3D analysis of the myenteric plexus of the human bowel by X-ray phase-contrast tomography - a future method?
CONCLUSIONS: Phase-contrast X-ray tomography can be applied for volume analyses of the human ENS and to study tissue components in unstained paraffin-embedded tissue biopsies. This technique could potentially be used to study disease mechanisms, and to compare healthy and diseased tissues in clinical research. PMID: 32907418 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Does urgent balloon-assisted enteroscopy impact rebleeding and short-term mortality in overt obscure gastrointestinal bleeding?
CONCLUSION: Urgent BAE might be associated with higher DY and TY with lower rebleeding and trend toward higher rebleeding-free time. PMID: 32907435 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Older age is a risk factor for inadequate energy intake during acute, severe IBD and is associated with shorter time to relapse.
Authors: Kulmala KA, Björk J, Andersson S, Backman AS, Eberhardson M, Bresso F, Hedin CRH Abstract BACKGROUND: Effects of nutritional intake on inflammatory bowel disease (IBD) flare resolution are unknown. We hypothesised that nutritional factors during hospitalisation for acute severe IBD are associated with risk of subsequent relapse. We also studied risk factors for inadequate energy intake. METHODS: Patients admitted to the Karolinska Hospital Gastroenterology ward with IBD flare during 2015-2016 were retrospectively identified. In total, 91 patients were included. Data on nutrition, disease factors, ...
Source: Scandinavian Journal of Gastroenterology - September 10, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Clinical and endoscopic features of esophageal tuberculosis: a 20-year retrospective study.
CONCLUSIONS: Esophageal tuberculosis is rare and frequently misdiagnosed due to the lack of diagnostic signs. There needs to be a high index of clinical suspicion among patients with dysphagia or retrosternal pain. Endoscopic biopsy and endoscopic ultrasound-guided FNA can help in achieving the correct diagnosis in esophageal tuberculosis. PMID: 32881605 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 7, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Learning curve for endoscopic submucosal dissection of early colorectal neoplasms with a monopolar scissor-type knife: use of the cumulative sum method.
Authors: Miyakawa A, Kuwai T, Sakuma Y, Kubota M, Nakamura A, Itobayashi E, Shimura H, Suzuki Y, Shimura K Abstract OBJECTIVE: Although scissor-type knives such as the Stag-Beetle (SB) Knife Jr are expected to result in a safe and easy colorectal endoscopic submucosal dissection (CR-ESD), information regarding the learning curve is lacking. Therefore, this study evaluated the learning curve with using SB Knife Jr. MATERIALS AND METHODS: We retrospectively reviewed 507 CR-ESD procedures performed in 464 patients using SB Knife Jr. The primary endpoint was a learning curve to achieve a satisfactory complete resec...
Source: Scandinavian Journal of Gastroenterology - August 28, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Diagnostic accuracy of faecal calprotectin in a symptom-based algorithm for early diagnosis of inflammatory bowel disease adjusting for differential verification bias using a Bayesian approach.
CONCLUSIONS: fCAL with a threshold set at 70 μg/g seems to represent a potentially reliable negative test to be used in primary care settings for patients with symptoms suggestive of IBD. PMID: 32838582 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 27, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Validation of ulcerative colitis and Crohn's disease and their phenotypes in the Danish National Patient Registry using a population-based cohort.
CONCLUSIONS: The DNPR has good validity and reliability in identifying patients with CD and UC, and defining the age of patients at diagnosis. However, categorising IBD patients according to the Montreal Classification should not be carried out using DNPR data in their current form, except when identifying CD patients with perianal disease. PMID: 32838593 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 27, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Genetic and shared environmental risk factors do not lead to eosinophil activation in healthy twins of IBD patients.
CONCLUSIONS: Activation of eosinophils in IBD seems to be a consequence of inflammation rather than an effect of genetic and shared environmental risk factors alone. PMID: 32815414 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 23, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Early serum infliximab trough level and mucosal healing could be predictors for one-year outcome after initiating therapy in Crohn's disease.
Authors: Tang J, Yang Q, Huang Z, Guo H, Chao K, Hu P, Gao X Abstract BACKGROUND AND AIMS: Serum infliximab trough level(S-IFX) and antibody were documented to correlate with clinical response. The aim of this study was to identify the relationship between early S-IFX, early mucosal healing (MH) and one-year outcome in a cohort on maintenance IFX therapy in Crohn's disease (CD). METHODS: The study group comprised of retrospectively enrolled patients diagnosed for Crohn's disease (n = 108). Patients received scheduled maintenance therapy after response to IFX induction, and had undergone the early ...
Source: Scandinavian Journal of Gastroenterology - August 23, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Use of antibiotics in acute pancreatitis: ten major concerns.
Authors: Soulountsi V, Schizodimos T Abstract Acute pancreatitis is one of the most common gastrointestinal causes for hospitalization. In 15-20% it evolves into severe necrotizing pancreatitis. Recent studies have shown no association between the initiation of antibiotic therapy in acute pancreatitis and severe outcomes such as organ failure, infection of pancreatic necrosis, extrapancreatic infections or mortality. Specific subgroups with predicted severe acute pancreatitis or both extensive sterile necrosis and persistent organ failure may benefit from prophylactic antibiotics. Local infection develops in 30% of...
Source: Scandinavian Journal of Gastroenterology - August 18, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Benign biliary strictures treated with biodegradable stents in patients with surgically altered anatomy using double balloon enteroscopy.
CONCLUSIONS: Treatment of biliary or anastomosis strictures in altered anatomy is complex and time consuming. The biodegradable stent, which can be passed through working channel of a long enteroscope, seems promising in the treatment of these strictures. The benefit is that no stent removal is needed. PMID: 32794409 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 15, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Outcome after endoscopic treatment for dysplasia and superficial esophageal cancer - a cohort study.
CONCLUSIONS: Endoscopic treatment is safe and efficient for treatment of dysplasia and superficial esophageal cancer. The two-years post-procedural level of HRQL and dysphagia was satisfactory. PMID: 32748653 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Outcomes and implications of diarrhea in patients with SARS-CoV-2 infection.
CONCLUSIONS: Diarrhea caused by high enteric viral burden may lead to long course and poor outcome in COVID-19 patients. The patients with diarrhea and respiratory symptoms were prone to serious condition, and had worse outcomes. However, the patients with diarrhea alone showed mild illness but delayed health-seeking. PMID: 32749177 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Magnetic resonance enterography perfusion parameters reveal complex changes in affected and unaffected segments in Crohn's disease.
CONCLUSIONS: Significant differences in perfusion parameters were observed between affected and unaffected segments of CD patients and between unaffected segments and those of control subjects. This suggests complex perfusion changes in both unaffected and affected intestinal segments in CD. PMID: 32757858 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Endoscopic and histologic activity assessment considering disease extent and prediction of treatment failure in ulcerative colitis.
This study aimed to evaluate DUBLIN score as a predictor of therapeutic failure as well as to associate endoscopic and histological activity scores to assess their joint performance. METHODS: Retrospective cohort study, with consecutive inclusion of patients undergoing total colonoscopy with serial biopsies between 2016 and 2019. DUBLIN score (0-9) was calculated as the product of Mayo endoscopic score (MSe 0-3) by disease extent (E1-E3). Histological activity was evaluated through Nancy score (0-4). Activity scores were correlated with biomarkers, treatment failure (therapeutic escalation, hospitalization and/or colec...
Source: Scandinavian Journal of Gastroenterology - August 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Faecal microbiota signatures of IBD and their relation to diagnosis, disease phenotype, inflammation, treatment escalation and anti-TNF response in a European Multicentre Study (IBD-Character).
We examined faecal samples, using the GA-map™ Dysbiosis Test, to associate gut microbiota composition with Crohn's disease (CD) and ulcerative colitis (UC) and to identify markers for future biomarker identification. We conducted a prospective case-control study (EU-ref. no. 305676) in an inception cohort of 324 individuals (64 CD, 84 UC, 116 symptomatic non-IBD controls and 44 healthy controls) across five European centres and examined 54 predetermined bacterial markers. We categorized patients according to the Montreal Classification and calculated the dysbiosis index (DI). Non-parametric tests were used to ...
Source: Scandinavian Journal of Gastroenterology - August 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Modified 'sandwich' injection with or without ligation for variceal bleeding in patients with both esophageal and gastric varices: a retrospective cohort study.
CONCLUSIONS: Based on this single-center retrospective study, both of the two kinds therapies appeared to have relatively favorable outcomes. With respect to the rebleeding rate at 1-year, modified 'sandwich' injection combined with EVL may be superior to modified 'sandwich' injection alone. PMID: 32780613 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Thumb sucking or nail biting in childhood and adolescence is associated with an increased risk of Crohn's disease: results from a large case-control study.
CONCLUSION: Contrary to our expectation and challenging the hygiene hypothesis, we found that common oral habits are not protective against IBD. Instead, nail biting at the time of school enrollment and coming-of-age was a statistically significant risk factor for CD in our cohort. Key summary Evidence available before this study: The hygiene hypothesis suggests that a reduction in microbial exposure due to improved health activities has contributed to an immunological imbalance in the intestine and an increased incidence of allergic and autoimmune diseases. A population-based birth cohort study has demonstrated that thumb...
Source: Scandinavian Journal of Gastroenterology - August 1, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The safety and efficacy of endoscopic ultrasound-guided ablation therapy for solid pancreatic tumors: a systematic review.
CONCLUSIONS: EUS-guided ablation therapy is a promising alternative treatment for solid pancreatic tumors, especially for p-NETs and insulinomas
Source: Scandinavian Journal of Gastroenterology - August 1, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Quality-of-life after bile duct injury repaired by hepaticojejunostomy: a national cohort study.
Authors: Sturesson C, Hemmingsson O, Månsson C, Sandström P, Strömberg C, Taflin H, Rystedt J Abstract OBJECTIVES: Reports on quality-of-life (QoL) after bile duct injury (BDI) show conflicting results. The aim of this cohort study was to evaluate QoL stratified according to type of treatment. METHODS: QoL assessment using the SF-36 (36-item short form health survey) questionnaire. Patients with post-cholecystectomy BDI needing hepaticojejunostomy (HJ) were compared to all other treatments (BDI repair) and to patients without BDI at cholecystectomy (controls). RESULTS: Patients needing a HJ ...
Source: Scandinavian Journal of Gastroenterology - August 1, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Use of genetic testing for hypolactasia trait in the North Denmark region.
CONCLUSIONS: In the North Denmark Region, a marked increase in the use of genetic testing for hypolactasia was observed and repeated testing was frequent. Furthermore, the use of the test and the test results were dependent on patient age and geographical origin. Results inform the debate on when and how to use genetic testing in the diagnosing of LI. PMID: 32723192 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - July 31, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research