The impact of increased immigration to Sweden on the incidence and treatment of patients with HCC and underlying liver disease.
Conclusions: Immigration increased the incidence of HCC and the need for active treatment such as LT. This fact raises the question of whether immigrants from regions with a high incidence of HCC ought to be subjected to mandatory hepatitis B and C virus (HBV and HCV) diagnosis and consequent liver ultrasounds for diagnosis of occult HCC. With such strategies, the morbidity and mortality of HCC could be reduced. PMID: 31190577 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 15, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Cost-effectiveness of Helicobacter pylori test and eradication versus upper gastrointestinal series versus endoscopy for gastric cancer mortality and outcomes in high prevalence countries.
Conclusions: H. pylori screening for the adults 50 years of age and older could be cost-effective compared to UGI and endoscopy in high prevalence countries. The main reasons for the superiority of H. pylori screening are that an H. pylori antibody test has a higher sensitivity and specificity than UGI and endoscopy and the benefits to reduce gastric cancer incidence and mortality. PMID: 31190581 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 15, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Clinical response to fecal microbiota transplantation in patients with diarrhea-predominant irritable bowel syndrome is associated with normalization of fecal microbiota composition and short-chain fatty acid levels.
Conclusions: FMT restores alterations of the gut microenvironment in IBS-D patients during the first 3 weeks and improves their symptoms for up to 28 weeks. ClinicalTrials.gov ID: NCT03333291. PMID: 31190584 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 15, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Ustekinumab for Crohn's disease: a nationwide real-life cohort study from Finland (FINUSTE).
Conclusion: UST showed to be effective and persistent, inducing short-term clinical benefit and endoscopic response in this real-life nationwide study of CD patients. Significant corticosteroid tapering in patients with highly treatment refractory and long-standing CD was observed. PMID: 31184512 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 13, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Indomethacin down-regulating HMGB1 and TNF- α to prevent pancreatitis after endoscopic retrograde cholangiopancreatography.
Indomethacin down-regulating HMGB1 and TNF-α to prevent pancreatitis after endoscopic retrograde cholangiopancreatography. Scand J Gastroenterol. 2019 Jun 08;:1-7 Authors: Li L, Liu M, Zhang T, Jia Y, Zhang Y, Yuan H, Zhang G, He C Abstract Background and aims: Several articles demonstrated that non-steroidal anti-inflammation drugs (NSAIDs) were effective in reducing the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography (PEP). However, studies revealed inconsistent results. The mechanism of NSAIDs in preventing PEP is still little known. Therefore, the aim of our stu...
Source: Scandinavian Journal of Gastroenterology - June 12, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Evaluation of preoperative prognostic factors in patients with resectable pancreatic ductal adenocarcinoma.
Conclusions: CA19-9 > 37 U/mL and tumor size>2.6 cm were preoperative independent risk factors for early recurrence and poor outcomes in patients with R-PDAC. Therefore, preoperative treatment should be considered for such patients. PMID: 31180790 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 12, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Effectiveness of steroid therapy for pancreatic cysts complicating autoimmune pancreatitis and management strategy for cyst-related complications.
Conclusions: Steroid therapy is an effective choice for cysts developing in AIP to promote the release of pancreatic juice stasis. Larger lesions with multilocular morphology should be monitored closely for cyst-related complications and be considered strong candidates for steroid therapy. PMID: 31164010 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 6, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Response of authors to the comment on 'mucosal miR-3677 is over-expressed in cirrhotic patients with gastric antral vascular ectasia'.
Authors: Garczorz W, Kimsa-Furdzik M, Francuz T, Żorniak M, Hartleb M PMID: 31165646 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - June 6, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Higher adalimumab serum levels do not increase the risk of adverse events in patients with inflammatory bowel disease.
Conclusions: There does not appear to be a relationship between adalimumab exposure and risk of adverse events in IBD patients. PMID: 31144993 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 31, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Impact of anti-TNF-alpha therapy on colectomy rate and indications for colectomy in ulcerative colitis: comparison of two patient cohorts from 2005 to 2007 and from 2014 to 2016.
This study was conducted retrospectively by comparing two cohorts of UC and indeterminate colitis patients that underwent colectomy in a single centre in HUH during the years 2005-2007 and 2014-2016. All patient data were collected from hospital patient records. Results: In 2005-2007 and 2014-2016, respectively, 2.3 and 18.8% of patients had received biological therapy and more specifically 2.3 and 10.5% infliximab within 3 months prior to colectomy. Colectomy rates were 8.6 (7.2-10.2) and 5.1 (4.3-6.1)/1.000 patient-years (p 
Source: Scandinavian Journal of Gastroenterology - May 30, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Outcomes of infected pancreatic necrosis complicated with duodenal fistula in the era of minimally invasive techniques.
Conclusion: IPN-DF could be managed successfully using minimally invasive techniques in specialized acute pancreatitis (AP) center. Patients with IPN-DF suffered from a longer hospital stay, but similar mortality rate compared with patients without DF. PMID: 31136208 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 30, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Prognosis and prognostic factors in patients with advanced biliary tract cancer depending on its anatomical location.
Authors: Song BG, Park JK, Kim HS, Kim K, Park JK, Lee KH, Lee KT, Lee JK Abstract Objective: Previous studies have revealed that biliary tract cancer (BTC) has different clinical characteristics depending on its anatomical location. However, clinical studies about the prognosis of BTC according to its anatomical location are lacking. We aimed to compare the prognosis of BTC according to its anatomical location. Methods: We retrospectively reviewed records of 311 patients with advanced BTC who received gemcitabine based palliative chemotherapy from January 2006 to December 2015 at Samsung medical Center. Results: D...
Source: Scandinavian Journal of Gastroenterology - May 30, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Endoscopic biliary drainage in patients with cholangiocarcinoma - self-expanding metal versus polyethylene stents.
Conclusions: Our data confirm that metal stenting reduces the frequency of interventions, but does not influence OS. Metal stenting should be considered specifically in younger patients who are suitable for chemotherapy. PMID: 31122083 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 29, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Technique and outcome of percutaneous endoscopic transgastric jejunostomy for continuous infusion of levodopa-carbidopa intestinal gel for treatment of Parkinson's disease.
Conclusions: Our PEG-J technique can be performed safely in patients with advanced PD, and favorable outcomes have been achieved to date. PMID: 31125265 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 29, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The relationship between Helicobacter pylori-related microbiota dysbiosis and gastrointestinal tract pathologies.
Authors: Kountouras J, Doulberis M, Papaefthymiou A, Polyzos SA, Touloumtzi M, Vardaka E, Kapetanakis N, Liatsos C, Gavalas E, Anastasiadis S, Tzivras D, Katsinelos P PMID: 31131650 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 29, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Efficacy and safety of curcumin in primary sclerosing cholangitis: an open label pilot study.
Conclusion: While curcumin was well tolerated, it was not associated with significant improvements in cholestasis or symptoms. Moreover, this study also illustrates that a low SAP is common among those with PSC. Abbreviations PSC: Primary sclerosing cholangitis; IBD: inflammatory bowel disease; CCA: cholangiocarcinoma; SAP: serum alkaline phosphatase; ULN: upper limit of normal; UDCA: ursodeoxycholic acid; CRP: c-reactive protein; AST: aspartate aminotransferase; ALT: alanine aminotransferase; INR: international normalized ratio; FIS: fatigue impact scale; AE: adverse events; PREsTo: PSC risk estimate tool; IQR: interquart...
Source: Scandinavian Journal of Gastroenterology - May 29, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Pharmacokinetics of golimumab in moderate to severe ulcerative colitis: the GO-KINETIC study.
Conclusions: After induction therapy, 60% of the patients showed endoscopic response. During maintenance therapy, about one third of patients discontinued GLM treatment because of loss of response. These patients might benefit from dose optimization. PMID: 31132014 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 29, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Real-world study of hepatitis C treatment with direct-acting antivirals in patients with drug abuse and opioid agonist therapy.
Conclusions: In this community-based study, DAAs are safe, effective with high overall SVR12 in patients with active drug use (injectable and non-injectable) and OAT enrolled patients. These results support the removal of drug use as a barrier to DAA therapy. PMID: 31120776 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 24, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Systematic review with meta-analyses: does the pathogen matter in post-infectious irritable bowel syndrome?
CONCLUSIONS: Current literature show similar risks for bacterial pathogens. Studies are limited for viral and parasitic pathogens. The evaluated risk-factors for PI-IBS varied among the included studies and the existing evidence is insufficient to identify pathogen-specific risk factors. PMID: 31112663 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 23, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Alterations in the relative abundance of Faecalibacterium prausnitzii correlate with changes in fecal calprotectin in patients with ileal Crohn's disease: a longitudinal study.
CONCLUSIONS: There was an inverse correlation between temporal changes in the relative abundance of F. prausnitzii, but not overall butyrate producing capacity, and changes in inflammatory activity in ileal Crohn's disease. These findings indicate that F. prausnitzii may play a role in gut homeostasis, even though causality is still to be demonstrated. PMID: 31104514 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 21, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Short Health Scale: a valid and reliable measure of quality of life in Dutch speaking patients with inflammatory bowel disease.
Authors: Coenen S, Weyts E, Geens P, Vermeire S, Ferrante M, Vanhaecht K, Van Assche G Abstract OBJECTIVES: Patient reported outcomes are widely used in today's clinical practice. The Short Health Scale has been proven to be an easy-to-use and reliable measure to evaluate quality of life in patients with inflammatory bowel disease. We aimed to validate this Short Health Scale in Dutch speaking patients. METHODS: A total of 157 Crohn's disease and ulcerative colitis patients (46% male, median age 39 years) completed the Short Health Scale on a tablet during the outpatient clinic. Validity was assessed by co...
Source: Scandinavian Journal of Gastroenterology - May 21, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

A single vial is enough in the absence of endoscopic suspected intestinal metaplasia - less is more!
CONCLUSION: In the absence of a typical endoscopic pattern of GIM using NBI, it is effective to place biopsies' specimens in the same vial (for Helicobacter pylori diagnosis) or even to abstain from biopsies as no single patient with significant changes seems to be missed. This change in clinical practice can have a significant impact on endoscopy costs. PMID: 31084230 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 17, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The accuracy of trans rectal ultrasonography (TRUS) in early-stage rectal cancer or benign adenomas.
CONCLUSION: TRUS can with great precision establish whether the tumor is benign so correct local treatment can be instituted. PMID: 31090476 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 17, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Comment on "Mucosal miR-3677 is over-expressed in cirrhotic patients with gastric antral vascular ectasia (GAVE)".
Comment on "Mucosal miR-3677 is over-expressed in cirrhotic patients with gastric antral vascular ectasia (GAVE)". Scand J Gastroenterol. 2019 May 16;:1 Authors: Zhang Y, Xu Y, Li C, Che L, Wang Y PMID: 31095437 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 17, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Adjuvant transcatheter arterial chemoembolization after radical resection of hepatocellular carcinoma patients with tumor size less than 5  cm: a retrospective study.
CONCLUSIONS: Adjuvant TACE does not improve the DFS of HCC patients with tumor size less than 5 cm. PMID: 31079496 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 14, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Upper gastrointestinal symptoms and associated endoscopic and histological features in patients receiving immune checkpoint inhibitors.
CONCLUSION: We observed a correlation between ICI use and onset of upper GI inflammation even when other risk factors were excluded. Gastric involvement was evident more often than duodenal involvement on endoscopic and histological level. PMID: 31079556 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 14, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Does postoperative adjuvant transarterial chemoembolization benefit for all patients with hepatocellular carcinoma combined with microvascular invasion: a meta-analysis.
Authors: Wang L, Ke Q, Lin N, Zeng Y, Liu J Abstract PURPOSE: To evaluate the clinical efficacy of postoperative adjuvant transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) patients combined with microvascular invasion (MVI). PATIENTS AND METHODS: Eligible studies were searched by PubMed, MedLine, Embase, the Cochrane Library, Web of Science, from 1st January 2000 to 31st December 2018, comparing the overall survival (OS) rates and disease-free survival (DFS) rates between postoperative adjuvant TACE and operation only for HCC patients with MVI. Hazard ratio (HR) with 95% confidence inter...
Source: Scandinavian Journal of Gastroenterology - May 14, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Safety and efficacy of cold polypectomy compared to endoscopic mucosal resection and hot biopsy polypectomy.
Authors: Iwashita H, Takedatsu H, Murao H, Funakoshi S, Kuniki Y, Matsuoka S, Tsukamoto S, Yamaguchi M, Shakado S, Kabemura T, Sakisaka S Abstract BACKGROUNDS: Recently, several studies have demonstrated the usefulness of cold polypectomy (CP), a safe and simple method for the removal of small polyps. We investigated the safety and efficacy of CP compared to that of endoscopic mucosal resection (EMR) and hot biopsy polypectomy (HB). METHODS: We retrospectively examined 1713 colorectal polyps (size 1-9 mm) in 731 patients. CP, EMR, and HB were performed on 476, 997, and 240 lesions, respectively. We compa...
Source: Scandinavian Journal of Gastroenterology - May 14, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Biochemical response to ursodeoxycholic acid among PBC patients: a nationwide population-based study.
CONCLUSION: Development of cirrhosis and higher mortality was significantly associated with a lack of biochemical response to UDCA. Frequent development of cirrhosis and increased mortality in nonresponders underlines the need for a more effective therapy than UDCA for this sizeable subgroup of patients. PMID: 31074667 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 11, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Comparison of 20-gauge Procore ® and 22-gauge Acquire® needles for EUS-FNB of solid pancreatic masses: an observational study.
Comparison of 20-gauge Procore® and 22-gauge Acquire® needles for EUS-FNB of solid pancreatic masses: an observational study. Scand J Gastroenterol. 2019 May 08;:1-7 Authors: Karsenti D, Tharsis G, Zeitoun JD, Denis P, Perrot B, Coelho J, Bellaiche G, Charbit L, Hakoune JJ, Doumet S, Sion-Rohart E, Cavicchi M, Zago J Abstract BACKGROUND AND AIMS: Endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) has been proposed to obtain high-quality tissue samples for pancreatic tumors. We performed an observational study to compare EUS-FNB with a 20-gauge Procore® needle versus a 22-gauge Acquir...
Source: Scandinavian Journal of Gastroenterology - May 10, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Macrophage markers soluble CD163 and soluble mannose receptor are associated with liver injury in patients with paracetamol overdose.
Authors: Siggaard CB, Kazankov K, Rødgaard-Hansen S, Møller HJ, Donnelly MC, Simpson KJ, Grønbaek H Abstract The macrophage activation markers, soluble CD163 (sCD163) and soluble mannose receptor (sMR), are associated with liver disease severity and prognosis. We aimed to investigate macrophage activation reflected by sMR and sCD163 in patients with mild and severe paracetamol (PCM) intoxication and effects of antidote treatment in patients and healthy controls. We measured sMR and sCD163 levels by in-house enzyme-linked immunosorbent assays in two independent prospective cohorts of PCM overdos...
Source: Scandinavian Journal of Gastroenterology - May 10, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Efficacy of preoperative colonoscopic tattooing with indocyanine green on lymph node harvest and factors associated with inadequate lymph node harvest in colorectal cancer.
CONCLUSION: PCT with ICG did not improve adequate LNH in colorectal cancer but effectively improved adequate LNH in early colorectal cancer. Male sex and early cancer were risk factors for inadequate LNH in colorectal cancer, so PCT is needed for adequate LNH in these patients. PMID: 31071272 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 10, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Attention deficit and hyperactivity disorder symptoms respond to gluten-free diet in patients with coeliac disease.
CONCLUSION: Prior to treatment, coeliac disease patients reported significantly more symptoms than healthy controls on ASRS and HADS. The differences disappeared after a minimum of 12 months on a gluten-free diet. PMID: 31050907 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 7, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Mapping the distribution of small bowel angioectasias.
CONCLUSIONS: Clinically significant angioectasias are overwhelmingly located within the proximal SB. The majority are within reach of conventional endoscopy. However, AEs are often multiple and many patients re-present following intervention. PMID: 31056967 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 7, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Research progress of P2X7 receptor in inflammatory bowel disease.
This article reviews the research progress of P2X7 receptor in inflammatory bowel disease. PMID: 31056977 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 7, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Genetic and flow cytometry analysis of seronegative celiac disease: a cohort study.
CONCLUSIONS: Seronegative CD differs mostly in genetic (more HLA-DQ8) and histologic (milder atrophy) features as compared with seropositive. Intestinal intraepithelial immunophenotype by flow cytometry, similar in both modalities, is a useful tool to diagnose seronegative CD. PMID: 31057009 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 7, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The study of methylation and single nucleotide polymorphisms of cancer-related genes in patients with early-stage ulcerative colitis.
CONCLUSION: In the early stage of UC, the methylation rate of cancer-related genes RUNX3 and COX2 and SNPs TNF-α rs1800629 and IL-1 rs1143627 were not significantly different compared with healthy subjects. The methylation rate of RUNX3 in CRC increased, while the methylation rate of COX2 and SNPs TNF-α rs1800629 and IL-1 rs1143627 did not change significantly compared with the other two groups. PMID: 31046486 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 4, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Incidental metastases and lymphoma of the gallbladder - an analysis of ten rare cases identified from a large national database.
CONCLUSION: Metastases and lymphoma of the gallbladder are rare. Traditional imaging methods prior to cholecystectomy may miss gallbladder malignancies. A liberal approach of histopathological analysis of the gallbladder should be applied. PMID: 31035806 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 2, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Efficacy and safety of endoscopic submucosal dissection for gastrointestinal neuroendocrine tumors: a 10-year data analysis of Northern China.
Authors: Chen X, Li B, Wang S, Yang B, Zhu L, Ma S, Wu J, He Q, Zhao J, Zheng Z, Li S, Wang T, Liang L Abstract OBJECTIVE: Endoscopy is the main method to treat gastrointestinal neuroendocrine tumors (GI-NETs), but the specific indications are still controversial. We aim to investigate the clinical outcomes of GI-NETs patients who experienced endoscopic submucosal dissection (ESD). METHODS: We retrospectively reviewed the clinical features and prognosis of 65 GI-NETs patients who underwent ESD between 2008 and 2018. RESULTS: A total of 65 patients diagnosed with GI-NETs pathologically, bearing 75 lesions, w...
Source: Scandinavian Journal of Gastroenterology - May 2, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Noninvasive testing in the management of children with suspected inflammatory bowel disease.
CONCLUSIONS: FC and increased BWT at IUS are accurate to guide reassurance or proceeding with further invasive procedures for detecting IBD in children with mild GI symptoms. PMID: 31032665 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 30, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Higher anti-TNF serum levels are associated with perianal fistula closure in Crohn's disease patients.
Authors: Strik AS, Löwenberg M, Buskens CJ, B Gecse K, I Ponsioen C, Bemelman WA, D'Haens GR Abstract OBJECTIVES: Anti-TNF agents are effective to treat perianal Crohn's disease (CD). Evidence suggests that Crohn's disease patients with perianal fistulas need higher infliximab (IFX) serum concentrations compared to patients without perianal CD to achieve complete disease control. Our aim was to compare anti-TNF serum concentrations between patients with actively draining and closed perianal fistulas. METHODS: A retrospective survey was performed in CD patients with perianal disease treated with IFX or adal...
Source: Scandinavian Journal of Gastroenterology - April 30, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Patient-oriented education and visual-aid intervention are inadequate to identify patients with potential capsule retention: a prospective randomized study.
CONCLUSIONS: Lack of visualization of capsule passage is a poor indicator of retention. Self-reporting of VCE passage status is suboptimal and the addition of a visual aid did not improve this parameter. PMID: 31034255 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 30, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Appendix, an evolutionary vestigial linked to colorectal cancer.
Authors: Wu SM, Lu KC, Lin EK, Chen CH, Huang CJ PMID: 31026184 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 27, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Repeat capsule endoscopy in suspected gastrointestinal bleeding.
CONCLUSIONS: It is known that CE can miss clinically relevant and serious lesions. Our results suggest that patients with an initially negative or inconclusive CE frequently have a cause of SB bleeding detected on repeat CE. The DY of repeat CE is highest in those with bleeding on their initial CE (83.3%) and lower in those with initially normal examinations (45.8%) or when an alternative cause, such as angioectasia is seen (14.2%). PMID: 31017489 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 26, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Analysis of risk factors of gastrointestinal stromal tumors in different age groups based on SEER database.
CONCLUSIONS: Age, gender, race, and surgical treatment are independent risk factors that influence the prognosis in patients with GISTs. Some risk factors affecting prognosis are age dependent. PMID: 31017491 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 26, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The high mortality of patients with common variable immunodeficiency and small bowel villous atrophy.
CONCLUSIONS: Although based on a small cohort, our results confirm that patients with CVID and villous atrophy are burdened by a very high mortality mainly due to onco-immunological disorders and infections. Strict follow-up is required in these patients. PMID: 31006294 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 24, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

An altered composition of the microbiome in microscopic colitis is driven towards the composition in healthy controls by treatment with budesonide.
Authors: Rindom Krogsgaard L, Kristian Munck L, Bytzer P, Wildt S Abstract BACKGROUND AND AIM: Microscopic colitis (MC) is an inflammatory disease of the bowel, hypothetically induced by an immunologic response to a luminal microbial agent. We aimed to characterize the microbiome composition in MC and subtypes collagenous colitis (CC) and lymphocytic colitis (LC) and to identify a possible microbial effect of treatment. METHOD: Stool samples were collected from MC patients prior to treatment, at 8 weeks (during treatment) and at 16 weeks (after treatment), and from healthy controls, not receiving trea...
Source: Scandinavian Journal of Gastroenterology - April 24, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Evaluation of fatigue in inflammatory bowel disease - a useful tool in daily practice.
Authors: Saraiva S, Cortez-Pinto J, Barosa R, Castela J, Moleiro J, Rosa I, da Siva JP, Dias Pereira A Abstract BACKGROUND: Fatigue is a common symptom reported in inflammatory bowel disease (IBD) patients. It can be severe and modify the self-perception of disease. OBJECTIVE: To evaluate the contribution of clinical and demographic factors to the level of fatigue in IBD patients. METHODS: Patients consecutively observed in an outpatient IBD clinic during a 9-month period were studied. Demographic and clinical data were collected. Fatigue was assessed using the Functional Assessment of Chronic Illness Thera...
Source: Scandinavian Journal of Gastroenterology - April 24, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Characteristics and risk factors for recurrence of nonalcoholic steatohepatitis following liver transplantation.
Authors: Tokodai K, Karadagi A, Kjaernet F, Romano A, Ericzon BG, Nowak G Abstract OBJECTIVES: Nonalcoholic steatohepatitis (NASH), which is a common and increasing indication for liver transplantation (LT), is known to recur after LT. Since the recurrence of NASH can lead to graft failure, the identification of predictive factors is needed and preventive strategies should be implemented. METHODS: We retrospectively examined 95 patients who had undergone LT for NASH or alcoholic liver disease (ALD) as a primary indication. We evaluated peritransplant characteristics and histological findings 1-year post LT amon...
Source: Scandinavian Journal of Gastroenterology - April 20, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Granulocyte-monocyte apheresis: an alternative combination therapy after loss of response to anti-TNF agents in ulcerative colitis.
CONCLUSIONS: Combination of GMA and anti-tumor necrosis factor is a safe and effective treatment after the loss of response to this biologic agents, with a significant decrease of the clinical disease activity and biomarkers, in a population with limited therapeutic alternatives. PMID: 30982369 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 17, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research