Faecal microbiota transplantation for eradication of co-infection with Clostridioides difficile and extensively drug-resistant KPC-producing Klebsiella pneumoniae.
Authors: Bahl MI, Jørgensen SMD, Skriver AH, Larsen NA, Wang M, Licht TR, Dahlerup JF, Hvas CL Abstract Clostridioides difficile infection may be complicated by co-infection with other pathogens. We here describe the successful use of faecal microbiota transplantation to eradicate concomitant C. difficile and extensively drug-resistant (XDR) KPC-producing Klebsiella pneumoniae. Donor microbiota efficiently engrafted in the patient, and a donor-like microbial assemblage persisted in the patient during six months follow-up. The report explores the potential for the donor microbiota to eradicate and replace mul...
Source: Scandinavian Journal of Gastroenterology - April 25, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Prediction of adenoma recurrence after piecemeal endoscopic mucosal resection: interobserver agreement and utilization of the Sydney EMR recurrence tool.
Authors: Silva JC, Pinho R, Fernades C, Proença L, Rodrigues A, Silva AP, Ponte A, Rodrigues J, Sousa M, Gomes AC, Afecto E, Carvalho J Abstract Background and aims: Piecemeal endoscopic mucosal resection (pEMR) allows resection of larger non-invasive colorectal lesions. Adenoma recurrence is an important limitation and occurs in ≤20%. The present study aimed to validate the Sydney EMR recurrence tool (SERT) score as a predictor of both endoscopic and histologic recurrence and evaluate interobserver agreement in adenoma recurrence based on endoscopic scar assessment, among nonexperts in EMR.Methods...
Source: Scandinavian Journal of Gastroenterology - April 25, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Is there any association between overweight, physical activity, fat and fiber intake with functional constipation in adolescents?
Conclusions: The prevalence of constipation was high among this group of adolescents. Constipation was not associated with physical inactivity but was associated with a low dietary fiber intake and higher BMI values in female adolescents. PMID: 32320314 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 23, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Plasma levels of guanylins are reduced in patients with Crohn's disease.
Conclusion: Our data indicate that diarrhea may be a determinant for levels of proGN in plasma, and should be further explored in studies of different diarrheal disorders. PMID: 32306784 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 22, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Large-scale epidemiological data on vascular disorders of the intestine.
Conclusions: Our analysis demonstrates that the clinical and societal burden of vascular disorders of the intestine is especially higher in women, in the elderly and in people with higher socioeconomic status. PMID: 32301364 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 19, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Clinical results and microbiota changes after faecal microbiota transplantation for chronic pouchitis: a pilot study.
Conclusions: Symptomatic benefit in FMT treatment was found for four of nine patients with chronic pouchitis with increased microbial diversity and high engraftment of donor's microbiota. A larger, randomised controlled study is required to fully evaluate the potential role of FMT in treating chronic pouchitis. PMID: 32285709 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 16, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Which obesity-associated parameters can better reflect the risk of the occurrence of the anastomotic leakage?
Conclusions: Serum triglycerides have potential as a predictive indicator for AL, which may improve the treatment and outcomes of patients with AL. PMID: 32285713 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 16, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Clinical features and monocyte/macrophage subsets characterization in granulomatous vs non-granulomatous Crohn's disease.
Conclusions: Granulomatous CD patients exhibited different manifestations compared with their non-granulomatous counterparts. More aggressive therapy may be needed in granulomatous CD patients. Furthermore, the heterogeneity of monocyte/macrophage subsets and altered plasma cytokine may underlie the difference between those two groups. PMID: 32285715 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 16, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Blood-based markers for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas - what's beyond the horizon?
Authors: Midlöv F, Ansari D, Aronsson L, Andersson R PMID: 32286902 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 16, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Increase in the incidence of alcoholic pancreatitis and alcoholic liver disease in Iceland: impact of per capita alcohol consumption.
Conclusions: Increase per capita alcohol consumption over a 15 year study period was associated with an increase in the incidence of severe alcoholic liver disease and alcohol-related acute pancreatitis in males but not in females. PMID: 32289240 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 16, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Inutility of endoscopic sphincterotomy to prevent pancreatitis after biliary metal stent placement in the patients without pancreatic duct obstruction.
Conclusions: ES prior to MS placement for patients with distal MBO without MPD obstruction does not reduce the incidence of PEP. PMID: 32275454 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 12, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Serological antibodies and surgery in a population-based inception cohort of Crohn's disease patients - the IBSEN study.
Conclusion: Positive ASCA IgA and IgG, and negative pANCA were associated with higher odds for CD-related surgery in univariate analysis. Since disease phenotype changes during the disease course, while serological antibodies are stable, our results support the use of pANCA, ASCA IgA and ASCA IgG as prognostic markers in CD. PMID: 32252542 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 9, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

An international polypectomy practice survey.
Conclusions: This survey found a substantial increase in CSP use during recent years. CSP has become the predominant polypectomy approach for 4‒10 mm colorectal polyps, while HSP remained the predominant approach for larger (10‒20 mm) polyps. Clinical practice patterns are well aligned with recently issued guideline recommendations. PMID: 32267187 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 9, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

S-POEM in treatment of achalasia and esophageal epiphrenic diverticula - single center experience.
Authors: Demeter M, Ďuriček M, Vorčák M, Hyrdel R, Kunda R, Bánovčin P Abstract Background: Standard treatment for esophageal epiphrenic diverticula associated with achalasia includes surgical diverticulectomy, myotomy and anterior fundoplication. However, several case reports published recently suggest that endoscopic approach using per oral endoscopic myotomy is a safe and effective alternative.Methods: This is a retrospective review of a single center case series of patients with achalasia and epiphrenic diverticula. During the treatment, the POEM guided on the opposite site of the diverticular...
Source: Scandinavian Journal of Gastroenterology - April 8, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Simplify to improve in capsule endoscopy - TOP 100 is a swift and reliable evaluation tool for the small bowel inflammatory activity in Crohn's disease.
Authors: Freitas M, Arieira C, Carvalho PB, Rosa B, Moreira MJ, Cotter J Abstract Background: Capsule endoscopy is a widely recognized method to study the small bowel, including in patients with Crohn's disease (CD). The Lewis score (LS) is a valuable tool in this setting, able to assess inflammatory activity. TOP100, a new software tool of the RAPID Reader®, emerged to assist in the time-consuming capsule reading process, by automatically selecting 100 images that will most likely contain abnormalities.Aim: Evaluate the agreement between TOP100 and classic reading (CR) in determining LS in the setting of CD.Me...
Source: Scandinavian Journal of Gastroenterology - April 3, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Pathophysiological-based treatments of complications of cirrhosis.
Authors: Møller S, Kimer N, Barløse M, Bendtsen F Abstract Detailed knowledge and understanding of the pathophysiological mechanisms and changes in hepatic and splanchnic function leading to the development of haemodynamic changes and portal hypertension in patients with cirrhosis are essential since it guides the search for targets to ameliorate liver-related abnormalities. Recent research has focused on the gut-liver axis, changes in intestinal permeability, translocation of bacterial products, and inflammation as important drivers of haemodynamic alterations and thereby targets for treatment. Addit...
Source: Scandinavian Journal of Gastroenterology - April 3, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Abstinence from alcohol and alcohol rehabilitation therapy in alcoholic liver disease: a population-based study.
Conclusion: Abstinence from alcohol following AC/AH diagnosis was achieved in 39% of patients. Abstinence was not related to increased survival for alcoholic liver disease patients at one-year, which might partly indicate that this might be a marker that some patients were 'too sick to drink'. AC and AH patients who survived one year and remained abstinent had a favorable long-term prognosis. PMID: 32233877 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 3, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The incidence and long-term outcomes of esophageal perforations in Finland between 1996 and 2017 - a national registry-based analysis of 1106 esophageal perforations showing high early and late mortality rates and better outcomes in patients treated at high-volume centers.
Conclusion: There is a slightly increasing trend in the occurrence of esophageal perforations. Contemporary treatment is less invasive with similar results. Patients treated in high-volume hospitals have better prognosis. PMID: 32233883 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 3, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The impact of body weight on dysplasia of colonic adenomas: a case-control study.
CONCLUSIONS: Our findings support the protective effect a normal weight against advanced adenomas. Reduction of BMI value should be pursued in healthy programs. PMID: 32233893 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 3, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Use of endoscopic assessment of gastric atrophy for gastric cancer risk stratification to reduce the need for gastric mapping.
Conclusions: Gastric cancer risk assessment using endoscopic or histologic methods provided similar results such that the absence or a mild grade of endoscopic gastric atrophy would preclude the need for histologic mapping. PMID: 32223458 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 2, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Risk factors for short recurrence-free survival after resection of pancreatic neuroendocrine tumor (PanNET) liver metastases: which patients should undergo resection?
Conclusions: These findings indicate that good candidates for resection of metastatic tumors of PanNETs could be patients with low Ki67 tumors and a small number of metastatic tumors. PMID: 32223573 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 2, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Percutaneous endoscopic gastrostomy: dealing with the issue of dislodgement.
Authors: Magalhães RS, Cúrdia Gonçalves T, Sousa-Pinto B, Rosa B, Marinho C, Cotter J Abstract Introduction: Percutaneous Endoscopic Gastrostomy (PEG) is accepted as an efficient method to provide long-term enteral nutrition. PEG accidental dislodgement (device exteriorization confirmed by expert evaluation) rate is high and can lead to major morbidity.Objective: To identify independent risk factors for PEG accidental dislodgement.Methods: Retrospective, single-center study, including consecutive patients submitted to PEG procedure, for 38 consecutive months. Every patient had 12 months ...
Source: Scandinavian Journal of Gastroenterology - March 24, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Elective surgery should be considered after successful conservative treatment of recurrent diverticular abscesses.
Conclusion: The majority of patients with diverticular abscesses had recurrences with repeated admissions regardless of abscess location. An unexpectedly high proportion of patients required surgical intervention during the follow-up period. A liberal approach regarding elective surgery for patients with recurrent diverticulitis abscesses who tolerate surgery seems justified. PMID: 32202966 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - March 24, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Health-related quality of life before and after liver transplantation in patients with primary sclerosing cholangitis.
Conclusions: HRQoL does not decrease markedly after LTx in the premalignant PSC group, and this group does cope better than the symptomatic PSC group. After LTx, mean HRQoL of the premalignant group stays close to that of the age- and gender-standardized general population. PMID: 32191135 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - March 20, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Prognostic relevance of programmed death-ligand 1 expression and microsatellite status in small bowel adenocarcinoma.
Conclusion: Although PD-L1 expression is associated with prolonged survival, it was not identified as an independent prognostic marker. Microsatellite status did not influence long-term survival. PMID: 32191146 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - March 20, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Endoscopic diagnosis of gastrointestinal melanoma.
Conclusions: GI melanoma is a rare disease. Most GI melanomas showed typical endoscopic manifestations, including black plaques. EUS is a reliable tool for evaluating the depth of infiltration of GI melanoma. PMID: 32191553 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - March 20, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Development and feasibility of a telemonitoring tool with full integration in the electronic medical record: a proof of concept study for patients with inflammatory bowel disease in remission on biological therapy.
Conclusions: We developed the mynexuzhealth IBD app with full integration in the electronic medical record. The app enabled continuous remote monitoring and showed accurate detection of flares. PMID: 32180470 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - March 19, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Correlation between antibiotic use in childhood and subsequent inflammatory bowel disease: a systematic review and meta-analysis.
Conclusions: There was a positive association between antibiotic use in childhood and the subsequently risk of Crohn's disease in non-European countries in the west during 2010-2013. Children in the United States taking antibiotics will have a higher risk of subsequently IBD than Europe, Asia and Australia. Registration number: CRD42019147648 (PROSPERO). PMID: 32180472 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - March 19, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Natural orifice specimen extraction with a modified reverse puncture device technique for total laparoscopic colorectal resection: feasibility and efficacy.
Conclusion: Total laparoscopic colorectal resection using mRPD is a technically feasible and safe procedure with satisfactory short-term efficacy. PMID: 32180478 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - March 19, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Osteoporosis in cirrhotics before and after liver transplantation: relation with malnutrition and inflammatory status.
This study aimed to in LT candidates investigate the potential relation between bone mineral density (BMD) and BMD loss in those who undergo LT, with malnutrition, systemic inflammation, and hormonal status.Methods: We included 102 consecutively recruited cirrhotic LT candidates between May 2004 and April 2007. BMD was assessed by means of dual energy X-ray absorptiometry (DXA). Malnutrition was defined by means of anthropometry and assessment of recent weight loss. In 75/102 patients, serum-thyroid stimulating hormone (TSH), free triiodthyronine (T3) and free thyroxine (T4) and growth hormone (GH), cortisol, free testoste...
Source: Scandinavian Journal of Gastroenterology - March 19, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Circadian rhythm abnormalities in patients with inflammatory bowel disease - association with adipokine profile.
Conclusions: The relationship between circadian rhythm abnormalities and specific adipokine profile may show us a risk factor of developing inflammatory intestinal lesions in IBD patients. This knowledge may allow the treatment of sleep disturbances, body weight-control and dietary habits become new targets in IBD therapy. PMID: 32180483 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - March 19, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Microscopic colitis and its associations with complications observed in classic inflammatory bowel disease: a systematic review.
Conclusions: Due to short follow-up time in small studies, with selection bias due to exclusion of former or prevalent malignancy in an older population, no conclusions can be drawn concerning the true association between MC and malignancy. Rheumatic diseases seem to be associated with MC. PMID: 32182146 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - March 19, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

S100A9 as a novel diagnostic and prognostic biomarker in human gastric cancer.
Authors: Zhao Z, Zhang C, Zhao Q Abstract Objective: The morbidity and mortality of gastric cancer (GC) is high, but there are lack of the biomarkers for early diagnosis and progression of GC. We aimed to identify a novel biomarker for the growth and progression of GC.Methods: The Cancer Genome Atlas (TCGA) database including 352 eligible patients was used to screen candidate genes related to the prognosis of GC. A proteomics analysis of Chinese Human Proteome Sketches (CHPS) including 84 eligible sample tissues was conducted to further identify candidate biomarkers. A series of in vitro assays were performed ...
Source: Scandinavian Journal of Gastroenterology - March 17, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Efficacy and safety of three different endoscopic methods in treatment of 6-20  mm colorectal polyps.
Efficacy and safety of three different endoscopic methods in treatment of 6-20 mm colorectal polyps. Scand J Gastroenterol. 2020 Mar 09;:1-9 Authors: Li D, Wang W, Xie J, Liu G, Wang R, Jiang C, Ye Z, Xu B, He X, Hong D Abstract Objective: Endoscopic resection of colorectal polyps is widely established as the optimal method to manage precancerous lesions. But the optimal technique for removal of the polyps is uncertain. The aim of this study was to compare the efficacy and safety of three methods for the management of 6-20mm colorectal polyps.Methods: A prospective, randomised controlled trial w...
Source: Scandinavian Journal of Gastroenterology - March 10, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Evaluation of the sensitivity of the Express View function in the Mirocam ® capsule endoscopy software.
Conclusions: The per-patient sensitivity for all lesions was shown to be below expectations, although the lesion detection rate, the per-patient sensitivity for all clinically significant lesions, and the diagnostic accuracy were shown to be higher. PMID: 32150486 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - March 10, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Treatment patterns for biologics in ulcerative colitis and Crohn's disease: a Danish Nationwide Register Study from 2003 to 2015.
Conclusions: The number of patients initiating biologic treatments after diagnosis increased throughout the study period. Most patients diagnosed with CD and UC are receiving biologic treatments relatively soon after their diagnosis. PMID: 32116064 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - March 3, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Cancer risk and chemoprevention in Chinese inflammatory bowel disease patients: a population-based cohort study.
Conclusion: Use of 5-ASA was not associated with a lowered cancer risk in Chinese IBD patients. Addition of statin/aspirin provided no additional benefit.Key summaryInflammatory bowel diseases (IBD) including Crohn's disease and ulcerative colitis are associated with increased risk of both intestinal and extra- intestinal cancers.Various medications including 5-aminosalicylate acid (5-ASA), statins and aspirin have been studied for their chemoprevention effects. However, most studies focused on colorectal cancer only and showed conflicting evidence. No studies so far looked at the effects of these medications on all cancer...
Source: Scandinavian Journal of Gastroenterology - March 3, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Relationship between autoimmune liver disease and autoimmune thyroid disease: a cross-sectional study.
Authors: Zeng Q, Zhao L, Wang C, Gao M, Han X, Chen C, Tu C, Han P, Li J Abstract Background: A high prevalence of autoimmune thyroid disease (AITD) has been observed in patients with autoimmune liver disease (AILD); however, data on the clinical relationship between AILD and AITD remain scant. We aimed to evaluate the relationship between AILD and AITD.Methods: We performed a retrospective study using medical records from 324 patients with AILD, 113 of whom had concurrent AITD.Results: Patients with autoimmune hepatitis (AIH) were more likely to develop AITD (45.8%), followed by autoimmune hepatitis-primary biliar...
Source: Scandinavian Journal of Gastroenterology - February 23, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The effect of nitrogen dioxide on low birth weight in women with inflammatory bowel disease: a Norwegian pregnancy cohort study (MoBa).
Conclusions: NO2 exposure influenced the risk of preterm birth in IBD mothers. Higher risk of preterm birth in IBD was associated with higher exposure of NO2, suggesting vulnerability of preterm birth in IBD when exposed to NO2. PMID: 32064969 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - February 19, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Sustained clinical benefit, improved quality of life, and reduced intestinal surgery from maintenance infliximab treatment in inflammatory bowel disease.
Conclusion: Two-thirds of the patients demonstrated stable clinical benefit from maintenance IFX. The results show steroid-sparing efficacy as well as improved quality of life and reduced need for surgery. PMID: 32052663 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - February 15, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Geographical variations in the incidence of oesophageal cancer in Sweden.
Conclusion: There are considerable geographical variations in the incidence and tumour stage distribution of oesophageal cancer in Sweden. PMID: 32045532 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - February 12, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Inter-reader agreement of interpretation of radiological course of bile duct changes between serial follow-up magnetic resonance imaging/3D magnetic resonance cholangiopancreatography of patients with primary sclerosing cholangitis.
Conclusions: Inter-reader agreement of the interpretation of radiological course of duct changes is poor in serial follow-up MRI/MRCP of PSC-patients. Elimination of 3 D MRCP does not increase inter-reader agreement but maintains an excellent intra-reader agreement for the interpretation of the dynamic course of bile duct changes.Key pointsInter-reader agreement of interpretation of radiological course of bile duct changes between serial follow-up MRI/MRCP examinations of patients with PSC is poor.Absence of 3D MRCP does not affect considerably the way readers interpret the radiological course of bile ducts changes....
Source: Scandinavian Journal of Gastroenterology - February 8, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Gastric erosion in laparoscopic gastric banding.
Authors: Shetty NS, Ghosh G, Wan D PMID: 32027516 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - February 8, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Particular aspects of gastroenterological disorders in chronic kidney disease and end-stage renal disease patients: a clinically focused review.
Authors: Costa-Moreira P, Vilas-Boas F, Teixeira Fraga A, Macedo G Abstract Besides renal disease, gastrointestinal (GI) disorders are frequently reported in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). Related gastrointestinal symptoms tend to increase as the renal disease progresses. Also, in patients with ESRD, the modality of dialysis is related to particular forms of GI disorders.The kidney can interact with the digestive organs through functional endogenous systems such as the 'kidney-colon axis' and the 'kidney-liver axis'. Digestive diseases are one of the visible manifesta...
Source: Scandinavian Journal of Gastroenterology - February 8, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Long-term use of proton pump inhibitors does not affect ectopic and metachronous recurrence of gastric cancer after endoscopic treatment.
Conclusions: Long-term use of PPIs does not affect ectopic and metachronous recurrence of GC after endoscopic treatment. PMID: 32008404 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - February 6, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Altered body composition profiles in young adults with childhood-onset inflammatory bowel disease.
Authors: Sigurdsson GV, Schmidt S, Mellström D, Ohlsson C, Karlsson M, Lorentzon M, Saalman R Abstract Background: Patients with inflammatory bowel disease (IBD) often develop alterations in body composition in terms of their proportions of lean mass and fat mass, as well as reduced bone mineral density (BMD). However, there are limited data on the skeletal muscle index (SMI) and percentage fat (fat %) for young adults with childhood-onset IBD. Our aim was to investigate the body compositions of these patients, with the focus on SMI and fat %.Methods: Body composition was estimated by dual x-ray absorptiometry...
Source: Scandinavian Journal of Gastroenterology - February 6, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Nomogram predicting cancer-specific survival in elderly patients with stages I-III colon cancer.
This study aims to establish and validate an effective nomogram to predict cancer-specific survival (CSS) in elderly patients with stages I-III colon cancer.Methods: The data of elderly colon cancer patients with stages I-III were enrolled from the Surveillance, Epidemiology, and End Results database (SEER) between 2010 and 2015. The eligible patients were randomly divided into a training cohort and a validation cohort (ratio 1:1). All predictors of cancer-specific survival were determined by Cox regression. The concordance index (C-index) and calibration curves were used for validation of nomograms. Decision curve analysi...
Source: Scandinavian Journal of Gastroenterology - February 6, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Hepatocellular carcinoma surveillance with liver imaging is not associated with improved survival.
Authors: Lang S, Martin A, Kasper P, Schramm C, Kütting F, Goeser T, Steffen HM, Demir M Abstract Objective: International guidelines recommend hepatocellular carcinoma (HCC) surveillance with ultrasound in high-risk patients with chronic liver diseases. However, there is low-strength evidence about the effects on mortality. The aim of our study was to assess the impact of surveillance on the clinical course and survival of HCC patients seen at a tertiary referral center in Germany.Material and methods: We retrospectively evaluated the data of 401 HCC patients, who presented to our clinic between 1997 and 2015...
Source: Scandinavian Journal of Gastroenterology - January 30, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Fecal calprotectin is more accurate than fecal immunochemical test for predicting mucosal healing in quiescent ulcerative colitis: a prospective multicenter study.
Authors: Kim ES, Lee HS, Kim SK, Kim EY, Jang BI, Kim KO, Yang CH, Lee YJ, Crohn’s and Colitis Association in Daegu-Gyeongbuk (CCAiD) Abstract Objective: Non-invasive stool tests, including the fecal immunochemical test (FIT) and fecal calprotectin (FC), are reliable biomarkers for mucosal healing (MH) in ulcerative colitis (UC). However, which fecal test is superior for predicting MH in inactive UC patients requires evaluation. We aimed to compare the accuracy of FIT and FC results for predicting MH in quiescent UC patients.Methods: This prospective, multicenter study was conducted at three tertiary hospital...
Source: Scandinavian Journal of Gastroenterology - January 29, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

A SEER population analysis of stage IB resected gastric cancer: who can benefit from adjuvant therapy?
This study aimed to offer a reference for the rational indications of AT.Methods: We retrospectively included 1216 stage IB GC who experienced curative surgery from the SEER database between 2004 and 2015. These patients were allocated into two groups: Group AT and Group surgery alone (Group SA). We established a nomogram to predict OS and then divided whole cohort into low-risk and high-risk groups based on the OS predicted by the nomogram.Results: Six variables, which were significantly related with OS of entire patients after matched, were incorporated in the nomogram. These variables were age, examined lymph nodes, tum...
Source: Scandinavian Journal of Gastroenterology - January 26, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research