Clinical course of Crohn's disease in a population-based cohort in Uppsala County followed for 10 years.
CONCLUSIONS: In the present study, the clinical course of CD was similar to previous reports during the first year after diagnosis, but the following years were considerably more stable with moderate increase of intestinal damage and totally a low frequency of surgery and no repeated surgery. PMID: 33016802 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - October 7, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Serum vitamin D level is related to disease progression in primary biliary cholangitis.
Authors: Wang Z, Peng C, Wang P, Sui J, Wang Y, Sun G, Liu M Abstract BACKGROUND AND AIM: A nonskeletal role of vitamin D in primary biliary cholangitis (PBC) patients is not yet clear. The purpose of this study is to investigate the serum vitamin D level in patients with PBC and to explore whether serum vitamin D level is related to disease progression. METHODS: The serum levels of 25(OH)D3 were measured in 185 PBC patients and 141 healthy controls. The association with vitamin D levels and disease progression, particularly natural course, was assessed. RESULTS: Serum vitamin D levels were measured in 185 ...
Source: Scandinavian Journal of Gastroenterology - October 7, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Safety and durability of PEG-J: a single-centre experience.
CONCLUSION: PEG-J placement and replacement are safe procedures. Although PEG-J durability is variable an elective procedure might be indicated to reduce urgent replacements. PMID: 33021876 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - October 7, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Comparison of conventional scoring systems versus MAGIC score to predict short-term mortality in patients hospitalized for alcoholic hepatitis.
Authors: Iyer A, Devadas K, Varghese A, Sreesh S Abstract BACKGROUND: Multiple prognostic models are available to predict mortality in alcoholic hepatitis (AH) which are of modest benefit, but the best model remains unexplored. METHODS: This is a retrospective analysis (2012-2015) of AH patients. Conventional prognostic scoring systems viz. Maddrey's Discriminant Function (mDF), Age Bilirubin International Normalized Ratio and Creatinine (ABIC), Glasgow Alcoholic Hepatitis Score (GAHS), and the Model for End-stage Liver Disease score (MELD), were compared with Model for AH to Grade the Severity in an Asian pati...
Source: Scandinavian Journal of Gastroenterology - October 3, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Predictors of insufficient recanalization and portal hypertensive complications after treatment of non-cirrhotic, non-malignant portal vein thrombosis - a population-based study.
We examined treatment outcomes in PVT and aimed to identify predictors of incomplete recanalization and portal hypertensive complications. MATERIALS AND METHODS: This retrospective study comprised patients diagnosed with PVT between 2006 and 2015. Key exclusion criteria were liver cirrhosis, malignancy, and age
Source: Scandinavian Journal of Gastroenterology - September 27, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Validity of administrative codes associated with cirrhosis in Sweden.
CONCLUSIONS: The validity of ICD-10 codes for cirrhosis, oesophageal varices and HCC is high. However, coding for ascites should be combined with a code of chronic liver disease to have an acceptable validity. PMID: 32960654 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 24, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Increased chronic pain in patients with ulcerative colitis is mostly associated to increased disease activity. A cross-sectional case-control study.
Authors: Pettersson N, Kragsbjerg F, Hamrin A, Bergman S, Forsblad-d'Elia H, Karling P Abstract BACKGROUNDS/AIMS: Musculoskeletal symptoms are common in patients with ulcerative colitis (UC), but no study has compared the prevalence of chronic pain to controls from a general population. METHODS: Patients with UC (n = 1164) and controls (n = 3867) were sent questionnaires comprising demography, history of pain, pain localization and UC patients' Patient-Simple Clinical Colitis Activity Index. Chronic regional pain (ChRP) and chronic widespread pain (ChWP) were defined as having pain f...
Source: Scandinavian Journal of Gastroenterology - September 20, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Gender, having a positive FIT and type of hospital are important factors for colonoscopy experience in colorectal cancer screening - findings from the SCREESCO study.
CONCLUSIONS: Although most participants were satisfied with the colonoscopy experience, the study has highlighted areas for improvement. Important factors for colonoscopy experience were gender, randomization group, and type of hospital and therefore crucial to bear in mind when designing screening programs. PMID: 32946700 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 20, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Childhood growth prior to screen-detected celiac disease: prospective follow-up of an at-risk birth cohort.
CONCLUSIONS: In the first 10 years of life, from prospectively collected serial growth measurements, we found no evidence of impaired childhood growth before CD and CDA development as identified through early and periodic screening. PMID: 32941083 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 19, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Gastrointestinal bleeding due to peptic ulcers and erosions - a prospective observational study (BLUE study).
CONCLUSIONS: The incidence of upper gastrointestinal bleeding due to peptic ulcers and erosions was found to be lower than previously demonstrated in comparable studies, but the overall mortality rate was unchanged. The consumption of risk medication was high, and only a few patients had used prophylactic PPIs. Concurrent H. pylori infection was present in only one-third of the patients. CLINICAL TRIAL REGISTRATION: Bleeding Ulcer and Erosions Study 'BLUE Study', ClinicalTrials.gov Identifier. NCT03367897. PMID: 32931710 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 17, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Arterial embolization for endoscopically unmanageable gastrointestinal bleeding remains the first-line therapy whatever the angiographic features.
Authors: Loffroy R, Falvo N, Midulla M, Chevallier O PMID: 32937085 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 17, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Non-surgical treatment of esophageal perforation after pneumatic dilation for achalasia: a case series.
We present four achalasia patients who underwent pneumatic dilatation, complicated by an esophageal perforation. All patients were treated successfully with endoscopic treatment: two patients with Eso-SPONGE® vacuum therapy, in the other two patients, esophageal defects were closed endoscopically using Endoclips. The time between dilatation and detection of the perforation was less than 24 h in all cases. Non-surgical treatment resulted in a relatively short hospital stay, ranging from 5 to 10 days, and an uneventful recovery in all patients. Based on our experience, endoscopic clipping and/or vacuum therapy are...
Source: Scandinavian Journal of Gastroenterology - September 16, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The risks and characteristics of the delayed bleeding after endoscopic submucosal dissection for early gastric carcinoma in cases with anticoagulants.
Authors: Saito H, Igarashi K, Hirasawa D, Okuzono T, Suzuki K, Abe Y, Nawata Y, Tanaka Y, Tanaka I, Unno S, Nishikawa Y, Tsubokura M, Nakahori M, Chonan A, Matsuda T Abstract BACKGROUND: Endoscopic submucosal dissection (ESD) is a minimally invasive treatment for early gastric carcinoma. Vitamin K antagonists and direct oral anticoagulants (DOAC) were reported to increase the risk of delayed bleeding after ESD. However, the evaluation of ESD cases taking anticoagulants is scarce. We analyzed the risk and characteristics of delayed bleeding after gastric ESD in patients on anticoagulants. METHODS: We performed a...
Source: Scandinavian Journal of Gastroenterology - September 16, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

3D analysis of the myenteric plexus of the human bowel by X-ray phase-contrast tomography - a future method?
CONCLUSIONS: Phase-contrast X-ray tomography can be applied for volume analyses of the human ENS and to study tissue components in unstained paraffin-embedded tissue biopsies. This technique could potentially be used to study disease mechanisms, and to compare healthy and diseased tissues in clinical research. PMID: 32907418 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Does urgent balloon-assisted enteroscopy impact rebleeding and short-term mortality in overt obscure gastrointestinal bleeding?
CONCLUSION: Urgent BAE might be associated with higher DY and TY with lower rebleeding and trend toward higher rebleeding-free time. PMID: 32907435 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Older age is a risk factor for inadequate energy intake during acute, severe IBD and is associated with shorter time to relapse.
Authors: Kulmala KA, Björk J, Andersson S, Backman AS, Eberhardson M, Bresso F, Hedin CRH Abstract BACKGROUND: Effects of nutritional intake on inflammatory bowel disease (IBD) flare resolution are unknown. We hypothesised that nutritional factors during hospitalisation for acute severe IBD are associated with risk of subsequent relapse. We also studied risk factors for inadequate energy intake. METHODS: Patients admitted to the Karolinska Hospital Gastroenterology ward with IBD flare during 2015-2016 were retrospectively identified. In total, 91 patients were included. Data on nutrition, disease factors, ...
Source: Scandinavian Journal of Gastroenterology - September 10, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Clinical and endoscopic features of esophageal tuberculosis: a 20-year retrospective study.
CONCLUSIONS: Esophageal tuberculosis is rare and frequently misdiagnosed due to the lack of diagnostic signs. There needs to be a high index of clinical suspicion among patients with dysphagia or retrosternal pain. Endoscopic biopsy and endoscopic ultrasound-guided FNA can help in achieving the correct diagnosis in esophageal tuberculosis. PMID: 32881605 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 7, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Learning curve for endoscopic submucosal dissection of early colorectal neoplasms with a monopolar scissor-type knife: use of the cumulative sum method.
Authors: Miyakawa A, Kuwai T, Sakuma Y, Kubota M, Nakamura A, Itobayashi E, Shimura H, Suzuki Y, Shimura K Abstract OBJECTIVE: Although scissor-type knives such as the Stag-Beetle (SB) Knife Jr are expected to result in a safe and easy colorectal endoscopic submucosal dissection (CR-ESD), information regarding the learning curve is lacking. Therefore, this study evaluated the learning curve with using SB Knife Jr. MATERIALS AND METHODS: We retrospectively reviewed 507 CR-ESD procedures performed in 464 patients using SB Knife Jr. The primary endpoint was a learning curve to achieve a satisfactory complete resec...
Source: Scandinavian Journal of Gastroenterology - August 28, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Diagnostic accuracy of faecal calprotectin in a symptom-based algorithm for early diagnosis of inflammatory bowel disease adjusting for differential verification bias using a Bayesian approach.
CONCLUSIONS: fCAL with a threshold set at 70 μg/g seems to represent a potentially reliable negative test to be used in primary care settings for patients with symptoms suggestive of IBD. PMID: 32838582 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 27, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Validation of ulcerative colitis and Crohn's disease and their phenotypes in the Danish National Patient Registry using a population-based cohort.
CONCLUSIONS: The DNPR has good validity and reliability in identifying patients with CD and UC, and defining the age of patients at diagnosis. However, categorising IBD patients according to the Montreal Classification should not be carried out using DNPR data in their current form, except when identifying CD patients with perianal disease. PMID: 32838593 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 27, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Genetic and shared environmental risk factors do not lead to eosinophil activation in healthy twins of IBD patients.
CONCLUSIONS: Activation of eosinophils in IBD seems to be a consequence of inflammation rather than an effect of genetic and shared environmental risk factors alone. PMID: 32815414 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 23, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Early serum infliximab trough level and mucosal healing could be predictors for one-year outcome after initiating therapy in Crohn's disease.
Authors: Tang J, Yang Q, Huang Z, Guo H, Chao K, Hu P, Gao X Abstract BACKGROUND AND AIMS: Serum infliximab trough level(S-IFX) and antibody were documented to correlate with clinical response. The aim of this study was to identify the relationship between early S-IFX, early mucosal healing (MH) and one-year outcome in a cohort on maintenance IFX therapy in Crohn's disease (CD). METHODS: The study group comprised of retrospectively enrolled patients diagnosed for Crohn's disease (n = 108). Patients received scheduled maintenance therapy after response to IFX induction, and had undergone the early ...
Source: Scandinavian Journal of Gastroenterology - August 23, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Use of antibiotics in acute pancreatitis: ten major concerns.
Authors: Soulountsi V, Schizodimos T Abstract Acute pancreatitis is one of the most common gastrointestinal causes for hospitalization. In 15-20% it evolves into severe necrotizing pancreatitis. Recent studies have shown no association between the initiation of antibiotic therapy in acute pancreatitis and severe outcomes such as organ failure, infection of pancreatic necrosis, extrapancreatic infections or mortality. Specific subgroups with predicted severe acute pancreatitis or both extensive sterile necrosis and persistent organ failure may benefit from prophylactic antibiotics. Local infection develops in 30% of...
Source: Scandinavian Journal of Gastroenterology - August 18, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Benign biliary strictures treated with biodegradable stents in patients with surgically altered anatomy using double balloon enteroscopy.
CONCLUSIONS: Treatment of biliary or anastomosis strictures in altered anatomy is complex and time consuming. The biodegradable stent, which can be passed through working channel of a long enteroscope, seems promising in the treatment of these strictures. The benefit is that no stent removal is needed. PMID: 32794409 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 15, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Outcome after endoscopic treatment for dysplasia and superficial esophageal cancer - a cohort study.
CONCLUSIONS: Endoscopic treatment is safe and efficient for treatment of dysplasia and superficial esophageal cancer. The two-years post-procedural level of HRQL and dysphagia was satisfactory. PMID: 32748653 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Outcomes and implications of diarrhea in patients with SARS-CoV-2 infection.
CONCLUSIONS: Diarrhea caused by high enteric viral burden may lead to long course and poor outcome in COVID-19 patients. The patients with diarrhea and respiratory symptoms were prone to serious condition, and had worse outcomes. However, the patients with diarrhea alone showed mild illness but delayed health-seeking. PMID: 32749177 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Magnetic resonance enterography perfusion parameters reveal complex changes in affected and unaffected segments in Crohn's disease.
CONCLUSIONS: Significant differences in perfusion parameters were observed between affected and unaffected segments of CD patients and between unaffected segments and those of control subjects. This suggests complex perfusion changes in both unaffected and affected intestinal segments in CD. PMID: 32757858 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Endoscopic and histologic activity assessment considering disease extent and prediction of treatment failure in ulcerative colitis.
This study aimed to evaluate DUBLIN score as a predictor of therapeutic failure as well as to associate endoscopic and histological activity scores to assess their joint performance. METHODS: Retrospective cohort study, with consecutive inclusion of patients undergoing total colonoscopy with serial biopsies between 2016 and 2019. DUBLIN score (0-9) was calculated as the product of Mayo endoscopic score (MSe 0-3) by disease extent (E1-E3). Histological activity was evaluated through Nancy score (0-4). Activity scores were correlated with biomarkers, treatment failure (therapeutic escalation, hospitalization and/or colec...
Source: Scandinavian Journal of Gastroenterology - August 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Faecal microbiota signatures of IBD and their relation to diagnosis, disease phenotype, inflammation, treatment escalation and anti-TNF response in a European Multicentre Study (IBD-Character).
We examined faecal samples, using the GA-map™ Dysbiosis Test, to associate gut microbiota composition with Crohn's disease (CD) and ulcerative colitis (UC) and to identify markers for future biomarker identification. We conducted a prospective case-control study (EU-ref. no. 305676) in an inception cohort of 324 individuals (64 CD, 84 UC, 116 symptomatic non-IBD controls and 44 healthy controls) across five European centres and examined 54 predetermined bacterial markers. We categorized patients according to the Montreal Classification and calculated the dysbiosis index (DI). Non-parametric tests were used to ...
Source: Scandinavian Journal of Gastroenterology - August 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Modified 'sandwich' injection with or without ligation for variceal bleeding in patients with both esophageal and gastric varices: a retrospective cohort study.
CONCLUSIONS: Based on this single-center retrospective study, both of the two kinds therapies appeared to have relatively favorable outcomes. With respect to the rebleeding rate at 1-year, modified 'sandwich' injection combined with EVL may be superior to modified 'sandwich' injection alone. PMID: 32780613 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 13, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Thumb sucking or nail biting in childhood and adolescence is associated with an increased risk of Crohn's disease: results from a large case-control study.
CONCLUSION: Contrary to our expectation and challenging the hygiene hypothesis, we found that common oral habits are not protective against IBD. Instead, nail biting at the time of school enrollment and coming-of-age was a statistically significant risk factor for CD in our cohort. Key summary Evidence available before this study: The hygiene hypothesis suggests that a reduction in microbial exposure due to improved health activities has contributed to an immunological imbalance in the intestine and an increased incidence of allergic and autoimmune diseases. A population-based birth cohort study has demonstrated that thumb...
Source: Scandinavian Journal of Gastroenterology - August 1, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The safety and efficacy of endoscopic ultrasound-guided ablation therapy for solid pancreatic tumors: a systematic review.
CONCLUSIONS: EUS-guided ablation therapy is a promising alternative treatment for solid pancreatic tumors, especially for p-NETs and insulinomas
Source: Scandinavian Journal of Gastroenterology - August 1, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Quality-of-life after bile duct injury repaired by hepaticojejunostomy: a national cohort study.
Authors: Sturesson C, Hemmingsson O, Månsson C, Sandström P, Strömberg C, Taflin H, Rystedt J Abstract OBJECTIVES: Reports on quality-of-life (QoL) after bile duct injury (BDI) show conflicting results. The aim of this cohort study was to evaluate QoL stratified according to type of treatment. METHODS: QoL assessment using the SF-36 (36-item short form health survey) questionnaire. Patients with post-cholecystectomy BDI needing hepaticojejunostomy (HJ) were compared to all other treatments (BDI repair) and to patients without BDI at cholecystectomy (controls). RESULTS: Patients needing a HJ ...
Source: Scandinavian Journal of Gastroenterology - August 1, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Use of genetic testing for hypolactasia trait in the North Denmark region.
CONCLUSIONS: In the North Denmark Region, a marked increase in the use of genetic testing for hypolactasia was observed and repeated testing was frequent. Furthermore, the use of the test and the test results were dependent on patient age and geographical origin. Results inform the debate on when and how to use genetic testing in the diagnosing of LI. PMID: 32723192 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - July 31, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Clinicopathological and molecular features of colorectal cancer with synchronous adenoma.
CONCLUSION: Gender, a habit of drinking and other neoplastic diseases are risk factors for the development of a synchronous adenoma. With a low rate of BRAF mutations, the responses to monoclonal antibody and prognosis of patients with synchronous adenomas may be better than that of solitary CRC. PMID: 32713220 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - July 28, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The role of claudin-4 in the development of gastric cancer.
Authors: Liu W, Li M Abstract Gastric cancer is one of most challenging cancers and a significant cause of death worldwide. Gastric cancer is, associated with a high incidence and recurrence rate of metastatic disease and poor survival for those with metastatic disease. Claudin-4 is a transmembrane protein that plays an important role in tight junctions. Increasing experimental research has demonstrated that claudin-4 plays an important role in the progression of gastric cancer, including the occurrence of epithelial to mesenchymal transition, intestinal metaplasia, and gastric cancer. In addition, claudin-4 regula...
Source: Scandinavian Journal of Gastroenterology - July 28, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

LIRER score - a valuable tool to predict medium-long-term outcomes in hepatic cirrhosis decompensation.
Authors: Freitas M, Xavier S, Magalhães R, Magalhães J, Marinho C, Cotter J Abstract BACKGROUND: The liver-renal-risk (LIRER) score was developed to predict adverse outcomes in cirrhotic patients with Model for End-stage Liver Disease (MELD)
Source: Scandinavian Journal of Gastroenterology - July 28, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Diagnostic and prognostic role of ascitic fluid calprotectin level: six-month outcome findings in cirrhotic patients.
Authors: Nasereslami M, Khamnian Z, Moaddab Y, Jalali Z Abstract AIM: To assess the role of ascites calprotectin in early detection of SBP in patients with cirrhosis and to investigate its prognostic value in determination of the 6-month outcome. Methods and material: In this cross-sectional study, patients with liver cirrhosis who were consecutively referred to Imam Reza hospital, tertiary referral center in the northwest of Iran, underwent abdominal paracentesis. The samples were collected for measurement of calprotectin, albumin, total protein, WBCs, and PMNs. RESULTS: The mean age of a total of 87 included ...
Source: Scandinavian Journal of Gastroenterology - July 28, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Child-Pugh, MELD, MELD-Na, and ALBI scores: which liver function models best predicts prognosis for HCC patient with ascites?
The objective of the present study is to compare the prognostic performance of 4 liver function models currently in use for HCC patients with ascites. METHODS: A total of 437 treatment-naïve, newly diagnosed HCC patients were analyzed. The predictive performance of Child-Pugh, MELD, MELD-Na, and ALBI scores were examined using ROC curve analysis. RESULTS: MELD-Na score showed good performance in predicting 1-, 2-, and 3-year mortality, particularly 1-year mortality. MELD-Na score significantly increased at 30 days after treatment in cases initially receiving best supportive care (14-17, p 
Source: Scandinavian Journal of Gastroenterology - July 25, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Colonoscopy adverse events: are we getting the full picture?
CONCLUSIONS: Colonoscopy carries important procedure and non-procedure related risks. Non-procedure related AEs are likely underreported. Better attention to patients with pre-existing diseases and further colonoscopist training may lower AE rates. A standardised colonoscopy AE reporting system is warranted. PMID: 32693644 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - July 24, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Diagnostic yield of endoscopic ultrasound-guided tissue acquisition of solid pancreatic lesions after inconclusive percutaneous ultrasound-guided tissue acquisition.
CONCLUSION: EUS-guided TA is safe and accurate for the diagnosis of pancreatic lesions after a previous inconclusive percutaneous approach. PMID: 32684051 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - July 22, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Biomarkers of liver fibrosis: prospective comparison of multimodal magnetic resonance, serum algorithms and transient elastography.
CONCLUSION: MRE and TE were superior for non-invasive identification of significant fibrosis. Serum fibrosis algorithms developed for specific liver diseases are applicable in this cohort of diverse liver diseases aetiologies. Gadoxetate-MRI was sufficiently sensitive to detect the low function losses associated with fibrosis. None was able to efficiently distinguish between stages within the low fibrosis stages. Lay summary Excessive accumulation of scar tissue, fibrosis, in the liver is an important aspect in chronic liver disease. To replace the invasive needle biopsy, we have explored non-invasive methods to assess liv...
Source: Scandinavian Journal of Gastroenterology - July 22, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Combination therapy in inflammatory bowel disease patients: do we need to maximize the dose of azathioprine?
Authors: Arieira C, Dias de Castro F, Cúrdia Gonçalves T, Moreira MJ, Cotter J Abstract BACKGROUND: The use of combination therapy of anti-TNFα and thiopurines in inflammatory bowel disease (IBD) is associated with greater efficacy and lower immunogenicity. However, the dose of thiopurine in this setting remains to be elucidated. AIM: To compare the trough levels, anti-TNFα antibodies and the inflammatory biomarkers between three groups in combotherapy: group 1 (dose of azathioprine
Source: Scandinavian Journal of Gastroenterology - July 22, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Programmed cell death protein 1 (PD-1)-inhibition in hepatocellular carcinoma (HCC): a single center experience.
CONCLUSIONS: Despite numerous pretreatments, PD-1 inhibition was well tolerated and showed clinical benefit in patients with heavily pretreated HCC. PMID: 32692941 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - July 22, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

The role of linked color imaging in endoscopic diagnosis of Helicobacter pylori associated gastritis.
Authors: Lee SP, Lee J, Kae SH, Jang HJ, Koh DH, Jung JH, Byeon SJ Abstract OBJECTIVE: Linked color imaging (LCI), a novel image-enhanced endoscopy, can make it easy to recognize differences in mucosal color. It may be helpful for diagnosing H. pylori associated gastritis and H. pylori infection status. We investigated whether LCI could improve the diagnostic accuracy of H. pylori associated gastritis. MATERIALS AND METHODS: Upper endoscopy was performed for 100 patients using white light imaging (WLI) and LCI. During the exam, endoscopic video was recorded. It was then analyzed by four expert endoscopists. The...
Source: Scandinavian Journal of Gastroenterology - July 18, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Concentration of fecal calprotectin in 11,255 children aged 0-18 years.
CONCLUSIONS: Fecal calprotectin values in children beyond the first year of life are in general low and comparable in children and adolescents. PMID: 32672082 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - July 18, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Progression of pancreatic morphology in chronic pancreatitis is not associated with changes in quality of life and pain.
Authors: Steinkohl E, Olesen SS, Drewes AM, Frøkjaer JB Abstract OBJECTIVES: In patients with chronic pancreatitis (CP), the aim was to explore the association between pancreatic morphological progression over four years and corresponding changes in disease characteristics, including quality of life (QOL), pain, and exocrine pancreatic function. METHODS: Twenty-five patients with CP were followed by magnetic resonance imaging (MRI). Data were obtained at baseline and after 4-year follow-up, including clinical information, QOL, and pain as assessed by validated questionnaires. Morphological assessments we...
Source: Scandinavian Journal of Gastroenterology - July 18, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Dysplasia in the mucosal biopsy specimen is still a warning sign of cancer in ulcerative colitis.
CONCLUSION: The incidence of ulcerative colitis-associated colorectal cancer remained constant in our study population over three decades. The prognosis of ulcerative colitis-associated colorectal cancer and the prognosis of sporadic colorectal cancer were comparable. One-third of the cancers were not diagnosed in preoperative colonoscopy, and the indication for surgery in such cases was dysplasia. We therefore do not recommend the endoscopic management of ulcerative colitis-associated dysplasia. PMID: 32672485 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - July 18, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Campylobacter concisus is prevalent in the gastrointestinal tract of patients with microscopic colitis.
Authors: Yde Aagaard ME, Frahm Kirk K, Linde Nielsen H, Harder Tarpgaard I, Bach Hansen J, Nielsen H Abstract OBJECTIVES: Microscopic colitis (MC) is potentially induced by an inflammatory reaction to a luminal gut factor. The emerging pathogen Campylobacter concisus is associated with prolonged diarrhoea and subsequently increased risk of MC. We aimed to examine the prevalence of C. concisus in clinical samples from MC patients, analyse the subtypes collagenous colitis (CC) and lymphocytic colitis (LC), and characterise C. concisus isolates from MC patients by genomic sequencing. METHODS: Mucosal biopsies were...
Source: Scandinavian Journal of Gastroenterology - July 17, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Experiences of using vedolizumab in the treatment of inflammatory bowel disease in the east Midlands UK - a retrospective observational study.
Authors: White JR, Din S, Ingram RJM, Foley S, Alam MA, Robinson R, Francis R, Tucker E, Jalal M, Elphick D, Atallah E, Norman A, Amin M, Sajjad A, Heggs N, Meadowcroft S, Moran GW Abstract PURPOSE: Clinical trials have demonstrated efficacy of vedolizumab in ulcerative colitis (UC) and Crohn's disease (CD). Further real-world data is needed to inform clinical practice. The primary outcome was to assess corticosteroid-free and clinical remission after vedolizumab initiation. Secondary outcomes included effect on disease activity scores, biochemical markers, concomitant drug use, endoscopic remission, surgical inter...
Source: Scandinavian Journal of Gastroenterology - July 15, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research