Clinical predictive value of Control attenuation parameters in combination with miR-192-5p in patients with acute pancreatitis in nonalcoholic fatty liver disease
CONCLUSIONS: NAFLD exacerbated the progression of AP, and CAP combined with miR-192-5p could predict the severity of AP. Our study may provide more reference for AP disease progression and treatment.PMID:38646989 | DOI:10.5603/ep.98765 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Yang Hu Liang Zhu Ronglai Cao Source Type: research
Modest effect of differential dietary vitamin A intake on the pathogenesis of alcohol-associated liver disease
CONCLUSIONS: Altered vitamin A intake and hepatic vitamin A storage have a minor effect on the pathogenesis of ALD. Thus, given the known link between altered retinoic acid signaling and ALD, future studies that further explore this linkage are warranted.PMID:38649284 | DOI:10.1111/acer.15329 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Afroza Ferdouse Robin D Clugston Source Type: research
DGAT2 Plays a Crucial Role to Control ESRRAPROX1 Transcriptional Network to Maintain Hepatic Mitochondrial Sustainability
CONCLUSION: DGAT2 sustains the stability of mitochondria in hepatoma via suppressing ESRRA-PROX1 transcriptional network and hinders HCC from shifting towards glycolytic metabolism, which lowers cell proliferation.PMID:38644620 | DOI:10.4093/dmj.2023.0368 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 22, 2024 Category: Endocrinology Authors: Yoseob Lee Yeseong Hwang Minki Kim Hyeonuk Jeon Seyeon Joo Sungsoon Fang Jae-Woo Kim Source Type: research
MAFLD with central obesity is associated with increased risk of colorectal adenoma and high-risk adenoma
To analyze the risk factors associated with colorectal adenoma and to investigate the associations of metabolism-related fatty liver disease (MAFLD) with obesity, colorectal adenoma and high-risk adenoma. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - April 22, 2024 Category: Gastroenterology Authors: Jingfang Xiong, Yijun Wu, Dongya Chen, Zhaolin Zhang, Yihui Liu, Jiandong Luo and Hong Xu Tags: Research Source Type: research
Tight Junction Proteins as Therapeutic Targets to Treat Liver Fibrosis and Hepatocellular Carcinoma
In conclusion, targeting Claudin proteins offers a novel clinical opportunity for the treatment of patients with advanced liver fibrosis and HCC. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - April 22, 2024 Category: Gastroenterology Authors: Saviano, Antonio Roehlen, Natascha Baumert, Thomas F. Tags: Review Article Source Type: research
Post-infectious ibs following Clostridioides difficile infection; role of microbiota and implications for treatment
Up to 25% of patients recovering from antibiotic-treated Clostridioides difficile infection (CDI) develop functional symptoms reminiscent of Post-Infectious Irritable Bowel Syndrome (PI-IBS). For patients with persistent symptoms following infection, a clinical dilemma arises as to whether to provide additional antibiotic treatment or to adopt a conservative symptom-based approach. Here, we review the literature on CDI-related PI-IBS and compare the findings with PI-IBS. We review proposed mechanisms, including the role of C. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 22, 2024 Category: Gastroenterology Authors: Dana Taghaddos, Zarwa Saqib, Xaiopeng Bai, Premysl Bercik, Stephen M. Collins Tags: Review Article Source Type: research
Assessing ChatGPT and perplexity AI performance
This study assessed ChatGPT 3.5 and Perplexity AI's performance in answering gastroenterology-related questions from the 2023 Italian national residency admissi on test (SSM23). The study contrasted the chatbots' performance and concordance with test results from prior years. The procedures comprised feeding SSM23 questions into the chatbots and calculating the sum of their scores and right answers. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 22, 2024 Category: Gastroenterology Authors: Hinpetch Daungsupawong, Viroj Wiwanitkit Tags: Correspondence Source Type: research
Gastritis cystica profunda presenting as an ulcerated lesion
A 57-year-old man was referred to our hospital due to repeated upper abdominal discomfort for more than 1 year. Endoscopy was performed 4 times in the past and gastric cancer was suspected, but biopsy showed inflammation. In our hospital, endoscopy showed a 2.5 cm diameter depressed lesion on the gastric angle (Fig. 1A) and magnifying narrow band imaging observed the central surface structure of the lesion disappeared (Fig. 1B). Endoscopic ultrasound (EUS) revealed a 0.8 × 0.7 cm anechoic area in the submucosa (Fig. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 22, 2024 Category: Gastroenterology Authors: Yang Li, Ruide Liu, Ziqiang Wang, Yi Mou Tags: Image of the Month Source Type: research
Updated mechanisms of MASLD pathogenesis
Metabolic dysfunction-associated steatotic liver disease (MASLD) has garnered considerable attention globally. Changing lifestyles, over-nutrition, and physical inactivity have promoted its development. MASLD ... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 22, 2024 Category: Lipidology Authors: Yuxuan Li, Peipei Yang, Jialu Ye, Qiyuan Xu, Jiaqi Wu and Yidong Wang Tags: Review Source Type: research
Ketogenic diet time-dependently prevents NAFLD through upregulating the expression of antioxidant protein metallothionein-2
The past few decades have witnessed a rapid growth in the prevalence of nonalcoholic fatty liver disease (NAFLD). While the ketogenic diet (KD) is considered for managing NAFLD, the safety and efficacy of the KD on NAFLD has been a controversial topic. Here, we aimed to investigate the effect of KD of different durations on metabolic endpoints in mice with NAFLD and explore the underlying mechanisms. (Source: Clinical Nutrition)
Source: Clinical Nutrition - April 22, 2024 Category: Nutrition Authors: Yuehua You, Yi Huang, Xiaoyang Wang, Hongbin Ni, Qin Ma, Haiying Ran, Jingshu Cai, Xiaojing Lin, Ting Luo, Chaodong Wu, Xiaoqiu Xiao, Li Ma Source Type: research
A high-dose of ursodeoxycholic acid treatment alleviates liver inflammation by remodeling gut microbiota and bile acid profile in a mouse model of non-alcoholic steatohepatitis
In conclusion, a high dosage of UDCA can alleviate liver inflammation, probably by modifying the composition of gut microbiota and serum bile acid profiles in NASH mice.PMID:38643542 | DOI:10.1016/j.biopha.2024.116617 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Hu Li Mingjie Wang Peizhan Chen Mingyu Zhu Li Chen Source Type: research
A high-dose of ursodeoxycholic acid treatment alleviates liver inflammation by remodeling gut microbiota and bile acid profile in a mouse model of non-alcoholic steatohepatitis
In conclusion, a high dosage of UDCA can alleviate liver inflammation, probably by modifying the composition of gut microbiota and serum bile acid profiles in NASH mice.PMID:38643542 | DOI:10.1016/j.biopha.2024.116617 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Hu Li Mingjie Wang Peizhan Chen Mingyu Zhu Li Chen Source Type: research
A case of refractory severe pyoderma gangrenosum successfully treated with upadacitinib
A 59-year-old woman affected by colonic Crohn's disease and perianal disease underwent colectomy and end ileostomy. Persistently active luminal disease was associated with severe pyoderma gangrenosum localized to the upper and lower limbs. Previous treatments with intravenous steroids and infliximab were not effective on pyoderma gangrenosum lesions. The image shows the evolution of a large and deep lesion localized on the right hand, after starting upadacitinib 45 mg once a day, with clear improvement and almost complete healing in 6 weeks of treatment (Fig. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 21, 2024 Category: Gastroenterology Authors: Marco Mendolaro, Enrico Morello, Paola Salacone, Rodolfo Rocca Tags: Image of the Month Source Type: research
Artificial intelligence-assisted colonoscopy to identify histologic remission and predict the outcomes of patients with ulcerative colitis: A systematic review
This systematic review evaluated the current status of AI-assisted colonoscopy to identify histologic remission and predict the clinical outcomes of patients with ulcerative colitis. The use of artificial intelligence (AI) has increased substantially across several medical fields, including gastrointestinal endoscopy. Evidence suggests that it may be helpful to predict histologic remission and relapse, which would be beneficial because current histological diagnosis is limited by the inconvenience of obtaining biopsies and the high cost and time-intensiveness of pathological diagnosis. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 21, 2024 Category: Gastroenterology Authors: Yasuharu Maeda, Shin-ei Kudo, Giovanni Santacroce, Noriyuki Ogata, Masashi Misawa, Marietta Iacucci Tags: Alimentary Tract Source Type: research
Author's reply: “Assessing ChatGPT and perplexity AI performance”
None. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 21, 2024 Category: Gastroenterology Authors: Raffaele Pellegrino, Antonietta Gerarda Gravina Tags: Correspondence Source Type: research
