Reduced bone mineral density is associated to post-TIPS survival of female patients with decompensated cirrhosis
Malnutrition is common in patients with cirrhosis, eventually leading to sarcopenia and loss of bone mass. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 27, 2024 Category: Gastroenterology Authors: Marlene Reincke, Jochen Seufert, Katharina Laubner, Maximilian Meyer-Steenbuck, Anna Dammer, Lukas Sturm, Robert Thimme, Dominik Bettinger, Michael Schultheiss Tags: Liver, Pancreas and Biliary Tract Source Type: research
In silico and network pharmacology analysis of fucosterol: a potent anticancer bioactive compound against HCC
AbstractThe Fucaceae family of marine brown algae includes Ascophyllum nodosum. Fucosterol (FSL) is a unique bioactive component that was identified through GC-MS analysis of the hydroalcoholic extract ofA. nodosum. Fucosterol's mechanism of action towards hepatocellular cancer was clarified using network pharmacology and docking study techniques. The probable target gene of FSL has been predicted using the TargetNet and SwissTargetPred databases. GeneCards and the DisGNet database were used to check the targeted genes of FSL. By using the web programme Venny 2.1, the overlaps of FSL and HCC disease demonstrated that 18 ge...
Source: Medical Oncology - April 27, 2024 Category: Cancer & Oncology Source Type: research
Inflammatory Protein Signatures as Predictive Disease-Specific Markers for Non-Alcoholic Steatohepatitis (NASH)
AbstractNon-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic disease worldwide, consisting of a broad spectrum of diseases such as simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatic inflammation plays a key role in the pathophysiology of NAFLD. Inflammatory mediators such as cytokines and chemokines are considered as contributing factors to NAFLD development and progression. In the present study, we aimed to investigate the inflammatory protein signatures as predictive disease-specific markers for non-alcoholic fatty liver disease (NA...
Source: Inflammation - April 27, 2024 Category: Allergy & Immunology Source Type: research
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.ABSTRACTA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive high cumulative doses for daily analgosedation and often already have impaired liver function due to an underlying disease or complications during treatment. A well-established biosensor based on HepG2/C3A cells was used for the determination of the hepatotoxicity of commonly used sedatives an...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Katharina Haller Sandra Do ß Martin Sauer Source Type: research
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.ABSTRACTA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive high cumulative doses for daily analgosedation and often already have impaired liver function due to an underlying disease or complications during treatment. A well-established biosensor based on HepG2/C3A cells was used for the determination of the hepatotoxicity of commonly used sedatives an...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Katharina Haller Sandra Do ß Martin Sauer Source Type: research
Triglyceride Glucose Index is Associated with Ultrasonographic Fatty Liver Indicator in Children and Adolescents with Non-alcoholic Fatty Liver Disease
CONCLUSION: TyG index was associated with the degree of hepatic steatosis, suggesting that it might be a useful tool for predicting the severity of pediatric NAFLD.PMID:38664989 | DOI:10.4274/jcrpe.galenos.2024.2024-2-5 (Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology)
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - April 26, 2024 Category: Endocrinology Authors: Bitgyeol Kim Hye Young Jin Jong Seo Yoon Eu Seon Noh Il Tae Hwang Source Type: research
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.ABSTRACTA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive high cumulative doses for daily analgosedation and often already have impaired liver function due to an underlying disease or complications during treatment. A well-established biosensor based on HepG2/C3A cells was used for the determination of the hepatotoxicity of commonly used sedatives an...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Katharina Haller Sandra Do ß Martin Sauer Source Type: research
Triglyceride Glucose Index is Associated with Ultrasonographic Fatty Liver Indicator in Children and Adolescents with Non-alcoholic Fatty Liver Disease
CONCLUSION: TyG index was associated with the degree of hepatic steatosis, suggesting that it might be a useful tool for predicting the severity of pediatric NAFLD.PMID:38664989 | DOI:10.4274/jcrpe.galenos.2024.2024-2-5 (Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology)
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - April 26, 2024 Category: Endocrinology Authors: Bitgyeol Kim Hye Young Jin Jong Seo Yoon Eu Seon Noh Il Tae Hwang Source Type: research
Efficacy and Safety of Fibroblast Growth Factor-21 Analogs for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis: A Systematic Review and Meta-Analysis
Clin Pharmacol Ther. 2024 Apr 26. doi: 10.1002/cpt.3278. Online ahead of print.ABSTRACTFibroblast growth factor (FGF)-21 analogs are potential therapeutic candidates for metabolic dysfunction-associated steatohepatitis (MASH). This systematic review and meta-analysis aimed to assess the efficacy and safety of the FGF-21 analogs, efruxifermin, pegbelfermin, and pegozafermin for MASH treatment. A comprehensive systematic review and meta-analysis of randomized controlled trials from five major databases was conducted. Primary efficacy outcomes focused on liver histological improvement, while secondary efficacy outcomes encomp...
Source: Clinical Pharmacology and Therapeutics - April 26, 2024 Category: Drugs & Pharmacology Authors: Changhyeon Jeong Nayoung Han Nakyung Jeon Su-Jin Rhee Christine E Staatz Min-Soo Kim In-Hwan Baek Source Type: research
The Role of Endoplasmic Reticulum Stress in Metabolic Diseases
Metab Syndr Relat Disord. 2024 Apr 26. doi: 10.1089/met.2024.0013. Online ahead of print.ABSTRACTThe endoplasmic reticulum (ER), the center of protein folding, also controls the cell's life-and-death signaling mechanisms. ER stress caused by unfolded or misfolded proteins leads to the activation of the unfolded protein response (UPR) in the cell. The UPR utilizes three main signaling pathways to restore disrupted ER homeostasis. These signaling pathways are protein kinase R-like endoplasmic reticulum kinase, inositol-requiring enzyme 1, and activating transcription factor 6. Studies have reported that ER stress (ERS) plays...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Firdevs Sak Fatma Sengul Husamettin Vatansev Source Type: research
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.ABSTRACTA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive high cumulative doses for daily analgosedation and often already have impaired liver function due to an underlying disease or complications during treatment. A well-established biosensor based on HepG2/C3A cells was used for the determination of the hepatotoxicity of commonly used sedatives an...
Source: Mol Biol Cell - April 26, 2024 Category: Molecular Biology Authors: Katharina Haller Sandra Do ß Martin Sauer Source Type: research
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.ABSTRACTA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive high cumulative doses for daily analgosedation and often already have impaired liver function due to an underlying disease or complications during treatment. A well-established biosensor based on HepG2/C3A cells was used for the determination of the hepatotoxicity of commonly used sedatives an...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Katharina Haller Sandra Do ß Martin Sauer Source Type: research
The hsa_circ_0082152 maintains NF- κB mRNA stability by binding to MTDH to promote anti-tuberculosis drug-induced liver injury
Int J Biol Macromol. 2024 Apr 24:131793. doi: 10.1016/j.ijbiomac.2024.131793. Online ahead of print.ABSTRACTAnti-tuberculosis drug-induced liver injury (ADLI) is a common adverse reaction during anti-tuberculosis treatment and often leads to treatment interruptions. Circular RNAs (circRNAs) have been identified as key modulators in liver diseases. CircRNAs is a special class of noncoding RNAs that have been found to have significant impacts on the progression of inflammation via various mechanisms. In the serum of ADLI patients, upregulation of the circular RNA hsa_circ_0082152 (derived from the host gene snd1) was observe...
Source: International Journal of Biological Macromolecules - April 26, 2024 Category: Biochemistry Authors: Lin Wang Chunyan Meng Yifei Long Yue Liu Luming Yang Xuelei Gao Shufeng Sun Fumin Feng Source Type: research
Triglyceride Glucose Index is Associated with Ultrasonographic Fatty Liver Indicator in Children and Adolescents with Non-alcoholic Fatty Liver Disease
CONCLUSION: TyG index was associated with the degree of hepatic steatosis, suggesting that it might be a useful tool for predicting the severity of pediatric NAFLD.PMID:38664989 | DOI:10.4274/jcrpe.galenos.2024.2024-2-5 (Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology)
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - April 26, 2024 Category: Endocrinology Authors: Bitgyeol Kim Hye Young Jin Jong Seo Yoon Eu Seon Noh Il Tae Hwang Source Type: research
The Role of Endoplasmic Reticulum Stress in Metabolic Diseases
Metab Syndr Relat Disord. 2024 Apr 26. doi: 10.1089/met.2024.0013. Online ahead of print.ABSTRACTThe endoplasmic reticulum (ER), the center of protein folding, also controls the cell's life-and-death signaling mechanisms. ER stress caused by unfolded or misfolded proteins leads to the activation of the unfolded protein response (UPR) in the cell. The UPR utilizes three main signaling pathways to restore disrupted ER homeostasis. These signaling pathways are protein kinase R-like endoplasmic reticulum kinase, inositol-requiring enzyme 1, and activating transcription factor 6. Studies have reported that ER stress (ERS) plays...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Firdevs Sak Fatma Sengul Husamettin Vatansev Source Type: research
