Pharmacological inhibition of the Src homology phosphatase 2 confers partial protection in a mouse model of alcohol-associated liver disease
This study aims to investigate the effects of Shp2 inhibition and its validity using a preclinical mouse model of ALD. We report that the administration of SHP099, a potent and selective allosteric inhibitor of Shp2, partially ameliorated ethanol-induced hepatic injury, inflammation, and steatosis in mice. Additionally, Shp2 inhibition was associated with reduced ethanol-evoked activation of extracellular signal-regulated kinase (ERK), oxidative, and endoplasmic reticulum (ER) stress in the liver. Besides the liver, excessive alcohol consumption induces multi-organ injury and dysfunction, including the intestine. Notably, ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 23, 2024 Category: Drugs & Pharmacology Authors: Ming-Fo Hsu Shinichiro Koike Chang-Shan Chen Sonia M Najjar Tzu-Ching Meng Fawaz G Haj Source Type: research
Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
This article reviews the recent research progress of GLP-1 in lipid metabolism.PMID:38650100 | DOI:10.4093/dmj.2023.0277 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 23, 2024 Category: Endocrinology Authors: Tong Bu Ziyan Sun Yi Pan Xia Deng Guoyue Yuan Source Type: research
Neutrophil to albumin ratio: a biomarker in non-alcoholic fatty liver disease and with liver fibrosis
CONCLUSION: These findings highlight that the novel inflammatory biomarker, NAR, is a convenient and easily accessible non-invasive predictor for NAFLD and NAFLD with liver fibrosis.PMID:38650638 | PMC:PMC11033504 | DOI:10.3389/fnut.2024.1368459 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Banghe Bao Shuang Xu Peng Sun Liduan Zheng Source Type: research
Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation
This study investigated the role of adiposity-associated orphan G protein-coupled receptor 75 (GPR75) in liver lipid accumulation. We profiled Gpr75 expression and report that it is most abundant in the brain. Next, we generated the first single-cell-level analysis of Gpr75 and identified a subpopulation co-expressed with key appetite-regulating hypothalamic neurons. CRISPR-Cas9-deleted Gpr75 mice fed a palatable western diet high in fat adjusted caloric intake to remain in energy balance, thereby preventing NAFLD. Consistent with mouse results, analysis of whole-exome sequencing data from 428,719 individuals (UK Biobank) ...
Source: Cell Metabolism - April 23, 2024 Category: Cytology Authors: Alasdair Leeson-Payne Jean Iyinikkel Cameron Malcolm Brian Y H Lam Nadine Sommer Georgina K C Dowsett Pablo B Martinez de Morentin Dawn Thompson Alasdair Mackenzie Raffaella Chianese Katherine Kentistou Eugene J Gardner John R B Perry Felix Grassmann John Source Type: research
Accelerated free-breathing liver fat and < mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" > < mml:mrow > < mml:msubsup > < mml:mi > R < /mml:mi > < mml:mn > 2 < /mml:mn > < mml:mo > * < /mml:mo > < /mml:msubsup > < /mml:mrow > < /mml:math > quantification using multi-echo stack-of-radial MRI with motion-resolved multidimensional regularized reconstruction: Initial retrospective evaluation
CONCLUSION: This proposed method may allow accelerated free-breathing liver PDFF and R 2 * $$ {\mathrm{R}}_2^{\ast } $$ mapping with reduced biases and variations.PMID:38650444 | DOI:10.1002/mrm.30117 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - April 23, 2024 Category: Radiology Authors: Xiaodong Zhong Marcel D Nickel Stephan A R Kannengiesser Brian M Dale Fei Han Chang Gao Shu-Fu Shih Qing Dai Omar Curiel Tsu-Chin Tsao Holden H Wu Vibhas Deshpande Source Type: research
Metabolic dysfunction-associated steatotic liver disease: Evolution of the final terminology
Eur J Intern Med. 2024 Apr 22:S0953-6205(24)00173-0. doi: 10.1016/j.ejim.2024.04.013. Online ahead of print.ABSTRACTThe medical term nonalcoholic fatty liver disease (NAFLD) was coined in 1986 for a condition that has since become the most prevalent liver disorder worldwide. In the last 3 years, the global professional community launched 2 consecutive efforts to purge NAFLD from the medical dictionary and recommended new terms based on disease pathophysiology rather than distinction from similar conditions featuring liver steatosis. A consensus by renowned clinical scholars primarily residing in the Asian-Pacific region in...
Source: European Journal of Internal Medicine - April 23, 2024 Category: Internal Medicine Authors: Piero Portincasa Gyorgy Baffy Source Type: research
Neutrophil to albumin ratio: a biomarker in non-alcoholic fatty liver disease and with liver fibrosis
CONCLUSION: These findings highlight that the novel inflammatory biomarker, NAR, is a convenient and easily accessible non-invasive predictor for NAFLD and NAFLD with liver fibrosis.PMID:38650638 | PMC:PMC11033504 | DOI:10.3389/fnut.2024.1368459 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Banghe Bao Shuang Xu Peng Sun Liduan Zheng Source Type: research
Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
This article reviews the recent research progress of GLP-1 in lipid metabolism.PMID:38650100 | DOI:10.4093/dmj.2023.0277 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Tong Bu Ziyan Sun Yi Pan Xia Deng Guoyue Yuan Source Type: research
Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
This article reviews the recent research progress of GLP-1 in lipid metabolism.PMID:38650100 | DOI:10.4093/dmj.2023.0277 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 23, 2024 Category: Endocrinology Authors: Tong Bu Ziyan Sun Yi Pan Xia Deng Guoyue Yuan Source Type: research
GSE195829 miRNA seq mouse liver HFD, PCB126, Aroclor1260 exposure
Contributors : Belinda J Petri ; Kellianne M Piell ; Bandrida Wahlang ; Kimberly Z Head ; Kalina Andreeva ; Eric C Rouchka ; Jianmin Pan ; Shesh N Rai ; Matthew C Cave ; Carolyn M KlingeSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusExposure to high fat diet (HFD) and persistent organic pollutants including polychlorinated biphenyls (PCBs) is associated with liver injury in human populations and with non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) in animal models. Exposure of HFD-fed male mice to the non-dioxin-like (NDL) PCB mixture Aroclor1260 or to dio...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Mus musculus Source Type: research
Blood cell parameters and risk of nonalcoholic fatty liver disease: a comprehensive Mendelian randomization study
Nonalcoholic fatty liver disease (NAFLD) is on the rise globally, and past research suggests a significant association with various blood cell components. Our goal is to explore the potential correlation betwe... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 23, 2024 Category: Genetics & Stem Cells Authors: Nan Zhu, Xiaoliang Wang, Huiting Zhu and Yue Zheng Tags: Research Source Type: research
Independent Associations of Aortic Calcification with Cirrhosis and Liver Related Mortality in Veterans with Chronic Liver Disease
This study ’s purpose was to evaluate AAC and liver-related death in a cohort of Veterans with chronic liver disease (CLD).MethodsWe utilized the VISN 10 CLD cohort, a regional cohort of Veterans with the three forms of CLD: NAFLD, hepatitis C (HCV), alcohol-associated (ETOH), seen between 2008 and 2014, with abdominal CT scans (n = 3604). Associations between MAC and cirrhosis development, liver decompensation, liver-related death, and overall death were evaluated with Cox proportional hazard models.ResultsThe full cohort demonstrated strong associations of MAC and cirrhosis after adjustment: HR 2.13 (95% CI 1.63, 2.7...
Source: Digestive Diseases and Sciences - April 23, 2024 Category: Gastroenterology Source Type: research
Establishing breath as a biomarker platform —take home messages from the Breath Biopsy Conference 2023
The annual Breath Biopsy Conference hosted by Owlstone Medical gathers together the leading experts, early career researchers, and physicians working with breath as a biomarker platform for clinical purposes. The current topics in breath research are discussed and presented, and an overarching topical theme is identified and discussed as part of an expert panel to close the conference. The profiling of normal breath composition and the establishment of standards for analyzing breath compared to background signal were two important topics that were major focuses of this conference, as well as important innovative progress t...
Source: Journal of Breath Research - April 23, 2024 Category: Respiratory Medicine Authors: Hsuan Chou, Lucy Godbeer and Madeleine L Ball Source Type: research
Comparison of the efficacy of the gadoxetic acid MRI-derived relative enhancement index (REI) and functional liver imaging score (FLIS) in predicting liver function: validation with Albumin-Bilirubin (ALBI) grade
ConclusionREI showed a very strong correlation with the ALBI grades for assessing liver function. It outperformed FLIS in predicting the ALBI grades, indicating its potential as a radiologic tool comparable to or better than FLIS in predicting liver function, especially given its dependence on liver volume.Graphical abstract (Source: Abdominal Imaging)
Source: Abdominal Imaging - April 23, 2024 Category: Radiology Source Type: research
Magnetic resonance elastography (MRE) outperforms acoustic force radiation impulse (ARFI) in predicting oesophageal varices in obese NAFLD cirrhosis
ConclusionIn obese NAFLD-CC, MRE-LSM is significantly higher in patients with varices. MRE combined with PC predicts EVs and HRVs with better accuracy than ARFI.Graphical abstract (Source: Abdominal Imaging)
Source: Abdominal Imaging - April 23, 2024 Category: Radiology Source Type: research
