Effectiveness and safety of high and low dose NOACs in patients with atrial fibrillation
Eur J Intern Med. 2021 Feb 18:S0953-6205(21)00037-6. doi: 10.1016/j.ejim.2021.01.031. Online ahead of print.NO ABSTRACTPMID:33612349 | DOI:10.1016/j.ejim.2021.01.031 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 22, 2021 Category: Internal Medicine Authors: Irene Marzona Marco Proietti Pierluca Colacioppo Andreana Foresta Marta Baviera Source Type: research

Effectiveness and safety of high and low dose NOACs in patients with atrial fibrillation
Eur J Intern Med. 2021 Feb 18:S0953-6205(21)00037-6. doi: 10.1016/j.ejim.2021.01.031. Online ahead of print.NO ABSTRACTPMID:33612349 | DOI:10.1016/j.ejim.2021.01.031 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 22, 2021 Category: Internal Medicine Authors: Irene Marzona Marco Proietti Pierluca Colacioppo Andreana Foresta Marta Baviera Source Type: research

Incidence and risk factors for preneoplastic and neoplastic lesions of the colon and rectum in patients under 50 referred for colonoscopy
Eur J Intern Med. 2021 Feb 17:S0953-6205(21)00045-5. doi: 10.1016/j.ejim.2021.02.008. Online ahead of print.ABSTRACTColorectal cancer (CRC) diagnosed before the age of 50, known as early-onset CRC (eoCRC), is considered uncommon. We aimed at analysing the incidence of preneoplastic and neoplastic lesions of the colon and rectum in patients under 50 years old and to identify possible predictors Methods: We retrospectively collected data from 1778 patients under 50 years old (mean age 39.9±7.8) referred for colonoscopy between 2015-2018. Cumulative incidence of adenomas and eoCRC was assessed. Multivariable regression...
Source: European Journal of Internal Medicine - February 21, 2021 Category: Internal Medicine Authors: Simona Agazzi Marco Vincenzo Lenti Catherine Klersy Elena Strada Lodovica Pozzi Laura Rovedatti Marco Bardone Aurelio Mauro Martina Costetti Stefania Costa Federico De Grazia Antonio Di Sabatino Source Type: research

Myocardial infarction during giant cell arteritis: A cohort study
CONCLUSIONS: GCA-related MI are mainly T2MI probably caused by systemic inflammation rather than coronaritis. GCA-unrelated MI are predominantly T1MI associated with atherothrombotic coronary artery disease.PMID:33610415 | DOI:10.1016/j.ejim.2021.02.001 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 21, 2021 Category: Internal Medicine Authors: H élène Greigert Marianne Zeller Alain Putot Eric Steinmetz B éatrice Terriat Maud Maza Nicolas Falvo G éraldine Muller Louis Arnould Catherine Creuzot-Garcher Andr é Ramon Laurent Martin Georges Tarris Tibor Ponnelle Sylvain Audia Bernard Bonnotte Y Source Type: research

Multidisciplinary prevention and management strategies for colorectal cancer and cardiovascular disease
Eur J Intern Med. 2021 Feb 17:S0953-6205(21)00040-6. doi: 10.1016/j.ejim.2021.02.003. Online ahead of print.ABSTRACTColorectal cancer (CRC) and cardiovascular disease (CVD) are leading causes of morbidity and mortality worldwide. Their numerous shared and modifiable risk factors underscore the importance of effective prevention strategies for these largely preventable diseases. Conventionally regarded as separate disease entities, clear pathophysiological links and overlapping risk factors represent an opportunity for synergistic collaborative efforts of oncologists and cardiologists. In addition, current CRC treatment app...
Source: European Journal of Internal Medicine - February 21, 2021 Category: Internal Medicine Authors: Seamus P Whelton Philipp Berning Roger S Blumenthal Catherine Handy Marshall Seth S Martin Martin B ødtker Mortensen Michael J Blaha Omar Dzaye Source Type: research

Cor homini lupus? Identification of risk factors implicated in cardiovascular events in patients with Systemic Lupus Erythematosus in Romania
Eur J Intern Med. 2021 Feb 17:S0953-6205(21)00044-3. doi: 10.1016/j.ejim.2021.02.007. Online ahead of print.NO ABSTRACTPMID:33608158 | DOI:10.1016/j.ejim.2021.02.007 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 20, 2021 Category: Internal Medicine Authors: Ergina Syrigou Dimitrios V Moysidis Andreas S Papazoglou Christos Tsagkaris Anna Maria Louka Anca Bobirca Source Type: research

Non-Specific Clinical Presentations are Not Prognostic and do not Anticipate Hospital Length of Stay or Resource Utilization
CONCLUSION: Our data suggest no utility for a categorisation of presentations as specific or non-specific in terms of provision of prognostic information nor as an indicator of the pattern of hospital investigation or LOS.PMID:33608159 | DOI:10.1016/j.ejim.2021.02.004 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 20, 2021 Category: Internal Medicine Authors: Richard Conway Declan Byrne Deirdre O'Riordan Bernard Silke Source Type: research

Treating life-threatening TAFRO syndrome with interleukin-1 inhibition
Eur J Intern Med. 2021 Feb 16:S0953-6205(21)00043-1. doi: 10.1016/j.ejim.2021.02.006. Online ahead of print.NO ABSTRACTPMID:33608160 | DOI:10.1016/j.ejim.2021.02.006 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 20, 2021 Category: Internal Medicine Authors: Marco Lanzillotta Miriam Sant'Angelo Naoki Kaneko Shiv Pillai Maurilio Ponzoni Emanuel Della-Torre Source Type: research

Sweet taste and obesity
Eur J Intern Med. 2021 Feb 13:S0953-6205(21)00023-6. doi: 10.1016/j.ejim.2021.01.023. Online ahead of print.ABSTRACTFor more than 50 years, there has been evidence for greater consumption of sweet- foods in overweight humans and animals, relative to those that have a normal weight. Furthermore, it has long been suggested that energy deficit resulting from dieting, while moving the individual from a higher weight set point, would result in heightened susceptibility to palatable tastants, namely to sweet tastants. This was the motivation behind the first studies comparing sweet taste perception between individuals with obesi...
Source: European Journal of Internal Medicine - February 17, 2021 Category: Internal Medicine Authors: Gabriela Ribeiro Albino J Oliveira-Maia Source Type: research

Estimated glomerular filtration rate and renal resistive index as possible predictive markers of mortality in systemic sclerosis
Eur J Intern Med. 2021 Feb 13:S0953-6205(21)00031-5. doi: 10.1016/j.ejim.2021.01.025. Online ahead of print.ABSTRACTOBJECTIVE: Subclinical nephropathy is underestimated in systemic sclerosis (SSc). Study aim is to evaluate the role of renal resistance indices (RRI) and estimated glomerular filtration rate (eGFR) assessed by Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) as predictive markers of mortality during 10 years of follow-up in SSc patients.METHODS: 181 SSc patients (60 years, 152 females) were enrolled. At baseline, the GFR was estimated in 181 SSc patients and RRI was measured in 122 SSc patients. Du...
Source: European Journal of Internal Medicine - February 17, 2021 Category: Internal Medicine Authors: Giorgia Leodori Chiara Pellicano Antonietta Gigante Edoardo Rosato Source Type: research

Cor homini lupus? Identification of risk factors implicated in cardiovascular events in patients with Systemic Lupus Erythematosus in Romania.
PMID: 33608158 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 17, 2021 Category: Internal Medicine Authors: Syrigou E, Moysidis DV, Papazoglou AS, Tsagkaris C, Louka AM, Bobirca A Tags: Eur J Intern Med Source Type: research

Non-Specific Clinical Presentations are Not Prognostic and do not Anticipate Hospital Length of Stay or Resource Utilization.
CONCLUSION: Our data suggest no utility for a categorisation of presentations as specific or non-specific in terms of provision of prognostic information nor as an indicator of the pattern of hospital investigation or LOS. PMID: 33608159 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 16, 2021 Category: Internal Medicine Authors: Conway R, Byrne D, O'Riordan D, Silke B Tags: Eur J Intern Med Source Type: research

Treating life-threatening TAFRO syndrome with interleukin-1 inhibition.
PMID: 33608160 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 16, 2021 Category: Internal Medicine Authors: Lanzillotta M, Sant'Angelo M, Kaneko N, Pillai S, Ponzoni M, Della-Torre E Tags: Eur J Intern Med Source Type: research

Sweet taste and obesity.
Abstract For more than 50 years, there has been evidence for greater consumption of sweet- foods in overweight humans and animals, relative to those that have a normal weight. Furthermore, it has long been suggested that energy deficit resulting from dieting, while moving the individual from a higher weight set point, would result in heightened susceptibility to palatable tastants, namely to sweet tastants. This was the motivation behind the first studies comparing sweet taste perception between individuals with obesity and those of a normal weight. These studies, using direct measures of taste, have been characte...
Source: European Journal of Internal Medicine - February 13, 2021 Category: Internal Medicine Authors: Ribeiro G, Oliveira-Maia AJ Tags: Eur J Intern Med Source Type: research

Estimated glomerular filtration rate and renal resistive index as possible predictive markers of mortality in systemic sclerosis.
Abstract OBJECTIVE: Subclinical nephropathy is underestimated in systemic sclerosis (SSc). Study aim is to evaluate the role of renal resistance indices (RRI) and estimated glomerular filtration rate (eGFR) assessed by Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) as predictive markers of mortality during 10 years of follow-up in SSc patients. METHODS: 181 SSc patients (60 years, 152 females) were enrolled. At baseline, the GFR was estimated in 181 SSc patients and RRI was measured in 122 SSc patients. During a follow-up of 10 years we recorded the main complications of disease, date and causes ...
Source: European Journal of Internal Medicine - February 13, 2021 Category: Internal Medicine Authors: Leodori G, Pellicano C, Gigante A, Rosato E Tags: Eur J Intern Med Source Type: research

Risk factors and current management of venous thromboembolism in patients with primary immune thrombocytopenic purpura.
PMID: 33568328 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 7, 2021 Category: Internal Medicine Authors: Tana M, Tana C, Rizzo G, Ricci F, Porreca E Tags: Eur J Intern Med Source Type: research

Inhaled long-acting muscarinic antagonists in asthma - A narrative review.
Abstract Long-acting muscarinic antagonists (LAMAs) have a recognised role in the management of chronic obstructive pulmonary disease. In asthma, muscarinic antagonists (both short- and long-acting) were historically considered less effective than β2-agonists; only relatively recently have studies been conducted to evaluate the efficacy of LAMAs, as add-on to either inhaled corticosteroid (ICS) monotherapy or ICS/long-acting β2-agonist (LABA) combinations. These studies led to the approval of the first LAMA, tiotropium, as an add-on therapy in patients with poorly controlled asthma. Subsequently, a numbe...
Source: European Journal of Internal Medicine - February 6, 2021 Category: Internal Medicine Authors: Papi A, Fabbri LM, Kerstjens HAM, Rogliani P, Watz H, Singh D Tags: Eur J Intern Med Source Type: research

Venous lactate improves the prediction of in-hospital adverse outcomes in normotensive pulmonary embolism.
it M Abstract BACKGROUND: Arterial lactate is an established risk marker in patients with pulmonary embolism (PE). However, its clinical applicability is limited by the need of an arterial puncture. In contrast, venous lactate can easily be measured from blood samples obtained via routine peripheral venepuncture. METHODS: We investigated the prognostic value of venous lactate with regard to in-hospital adverse outcomes and mortality in 419 consecutive PE patients enrolled in a single-center registry between 09/2008 and 09/2017. RESULTS: An optimised venous lactate cut-off value of 3.3 mmol/l predict...
Source: European Journal of Internal Medicine - February 5, 2021 Category: Internal Medicine Authors: Ebner M, Pagel CF, Sentler C, Harjola VP, Bueno H, Lerchbaumer MH, Stangl K, Pieske B, Hasenfuß G, Konstantinides SV, Lankeit M Tags: Eur J Intern Med Source Type: research

Patient motivation to lose weight: Importance of healthcare professional support, goals and self-efficacy.
Caterson ID Abstract BACKGROUND: People with obesity (PwO) often struggle to achieve and maintain weight loss. This can perpetuate and/or be influenced by feelings of low motivation. This analysis from ACTION-IO data identified factors associated with PwO motivation to lose weight. METHODS: PwO completed an online survey in 11 countries. Exploratory multinomial logistic regression analyses identified independent variables associated with self-report of feeling motivated versus not motivated to lose weight. RESULTS: Data from 10,854 PwO were included (5,369 motivated; 3,312 neutral; 2,173 not motivated). ...
Source: European Journal of Internal Medicine - February 5, 2021 Category: Internal Medicine Authors: Dicker D, Alfadda AA, Coutinho W, Cuevas A, Halford JCG, Hughes CA, Iwabu M, Kang JH, Nawar R, Reynoso R, Rhee N, Rigas G, Salvador J, Sbraccia P, Vázquez-Velázquez V, Caterson ID Tags: Eur J Intern Med Source Type: research

Prediction and primary prevention of major vascular complications in systemic sclerosis.
CONCLUSIONS: in SSc patients, our data confirm the role of arthritis and dyspnea as independent predictors of major vascular complications, in particular in MVCs-naïve patients. Prostanoids, sildenafil and ARBs, even in absence of a primary preventive action, might help in slowing disease progression and postponing the onset of MVCs. PMID: 33551291 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 5, 2021 Category: Internal Medicine Authors: Bruni C, Cometi L, Gigante A, Rosato E, Matucci-Cerinic M Tags: Eur J Intern Med Source Type: research

Long-term effectiveness and safety of anticoagulation therapy in oldest old, frail people with atrial fibrillation.
Abstract BACKGROUND: Atrial Fibrillation (AF) represents a major cause of mortality and morbidity in older people; however, oldest-old frail patients are usually excluded from clinical trials. Aim of the study is to evaluate the impact of oral anticoagulation (OAC) therapy on long-term overall survival and clinically relevant bleedings in a large cohort of hospitalised frail, oldest-old patients with AF. PATIENTS AND METHODS: Prospective, observational, cohort study, evaluating patients consecutively hospitalized for acute illnesses in our Geriatrics Unit (January 2013-July 2017). Participants were divided in...
Source: European Journal of Internal Medicine - February 4, 2021 Category: Internal Medicine Authors: Calsolaro V, Okoye C, Antognoli R, Dell'Agnello U, Calabrese AM, Monzani F Tags: Eur J Intern Med Source Type: research

Postoperative atrial fibrillation after non-cardiac surgery: How important is it and what do we do about it?
PMID: 33549408 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 3, 2021 Category: Internal Medicine Authors: Wang MK, Douketis J Tags: Eur J Intern Med Source Type: research

How specific are elevated IgG4 levels for IgG4-related disease?
PMID: 33541828 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 1, 2021 Category: Internal Medicine Authors: Schils M, Betrains A, Vanderschueren S, Bossuyt X, Blockmans D Tags: Eur J Intern Med Source Type: research

A forgotten disease in Japan.
PMID: 33531201 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - January 31, 2021 Category: Internal Medicine Authors: Matsuura H, Deguchi K Tags: Eur J Intern Med Source Type: research

A man with arthralgias and skin lesions.
ve; F PMID: 33518402 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - January 28, 2021 Category: Internal Medicine Authors: Elia F, Protti G, Aprà F Tags: Eur J Intern Med Source Type: research

Beyond the 2020 guidelines on atrial fibrillation of the European society of cardiology.
Abstract The most recent atrial fibrillation (AF) guidelines delivered by European Society of Cardiology (ESC) offer an updated approach to AF management, with the perspective of improved characterization of the arrhythmia, the cardiac substrate and the patients profile in terms of associated risk factors and comorbidities. Recommendations were based on careful scrutiny and assessment of all available evidence with the final aim to offer to practitioners a lower level of uncertainty in the complex process of decision making for patients with AF. The 2020 ESC guidelines on AF propose a paradigm shift in the clinica...
Source: European Journal of Internal Medicine - January 28, 2021 Category: Internal Medicine Authors: Boriani G, Vitolo M, Lane DA, Potpara TS, Lip GY Tags: Eur J Intern Med Source Type: research

The Diagnosis of Acute Myocarditis in Emergency (DAME) score: improving diagnostics within the emergency department.
Abstract PURPOSE: . The final diagnosis of myocarditis is challenging. The aim of our study was to provide the D.A.M.E. (Diagnosis of Acute Myocarditis in Emergency) Score for the fast identification of patients suffering from myocarditis at Emergency Department (ED). METHODS: . This was a multicenter, retrospective study involving three centers. All medical records from January 2010 to December 2014 reporting a final discharge diagnosis of myocarditis were considered. One hundred-four patients (mean age: 40.2±16.5 years) were enrolled. Clinical, biochemical and instrumental data were gathered. Data we...
Source: European Journal of Internal Medicine - January 24, 2021 Category: Internal Medicine Authors: Scicchitano P, Grazioli Gauthier L, D'Agostino C, Caldarola P, Solarino B, Massari F, Chiarella F, Sinagra G, Manca F, Ciccone MM Tags: Eur J Intern Med Source Type: research

The 3Ds - Discussion, diagnosis and direction: Elements for effective obesity care by healthcare professionals.
CONCLUSION: Specific actions that could improve obesity care through the 3D approach include: encouraging HCPs to record an obesity diagnosis; providing tools to help HCPs feel more comfortable initiating weight discussions; and provision of training in obesity management. CLINICAL TRIAL REGISTRATION: NCT03584191. PMID: 33495083 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - January 23, 2021 Category: Internal Medicine Authors: Alfadda AA, Caterson ID, Coutinho W, Cuevas A, Dicker D, Halford JCG, Hughes CA, Iwabu M, Kang JH, Nawar R, Reynoso R, Rhee N, Rigas G, Salvador J, Vázquez-Velázquez V, Sbraccia P Tags: Eur J Intern Med Source Type: research

Longitudinal trends and outcomes of adult heart transplantation in the U.S.
PMID: 33495082 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - January 22, 2021 Category: Internal Medicine Authors: Akintoye E, Asleh R, Alvarez P, Briasoulis A Tags: Eur J Intern Med Source Type: research

Vertebral level identified by the intercristal line: Confirmation by ultrasound.
PMID: 33495084 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - January 22, 2021 Category: Internal Medicine Authors: Brotherston D, Desy J, Ma IWY Tags: Eur J Intern Med Source Type: research

PPI co-therapy and gastrointestinal bleeding with antithrombotic drugs: A step forward but not enough.
PMID: 33487506 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - January 21, 2021 Category: Internal Medicine Authors: Lanas A Tags: Eur J Intern Med Source Type: research

Impact of the number of comorbidities on cardiac sympathetic derangement in patients with reduced ejection fraction heart failure.
CONCLUSION: In systolic HF patients, the number of comorbidities is not associated with alterations in cardiac adrenergic innervation. These results are consistent with the observation that very comorbid HF patients suffer lower risk of sudden cardiac death. PMID: 33485737 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - January 20, 2021 Category: Internal Medicine Authors: Bencivenga L, Komici K, Femminella GD, Paolillo S, Gargiulo P, Formisano R, Assante R, Nappi C, Puzone B, Sepe I, Cittadini A, Vitale DF, Ferrara N, Cuocolo A, Filardi PP, Rengo G Tags: Eur J Intern Med Source Type: research

Do four SGLT2 inhibitors lead to different cardiorenal benefits in type 2 diabetes, in chronic heart failure, and in chronic kidney disease?
PMID: 33485738 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - January 20, 2021 Category: Internal Medicine Authors: Qiu M, Ding LL, Zhan ZL, Zhou HR Tags: Eur J Intern Med Source Type: research

Cannabis is associated with blood pressure reduction in older adults - A 24-hours ambulatory blood pressure monitoring study.
Abstract BACKGROUND: Medical cannabis use is increasing rapidly in the past several years, with older adults being the fastest growing group. Nevertheless, the evidence for cardiovascular safety of cannabis use is scarce. The aim of this study was to assess the effect of cannabis on blood pressure, heart rate, and metabolic parameters in older adults with hypertension. METHODS: We conducted a prospective study of patients aged 60 years or more with hypertension and a new prescription of cannabis. We have performed the following assessments: 24-hours ambulatory blood pressure monitoring, ECG, blood tests, and ...
Source: European Journal of Internal Medicine - January 20, 2021 Category: Internal Medicine Authors: Abuhasira R, Haviv YS, Leiba M, Leiba A, Ryvo L, Novack V Tags: Eur J Intern Med Source Type: research

Serum uric acid levels: A surrogate marker of oxidative stress or dehydration?
PMID: 33478855 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - January 18, 2021 Category: Internal Medicine Authors: Ito H Tags: Eur J Intern Med Source Type: research

Less is more: Perspectives from the European Code Against Cancer.
PMID: 33468373 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - January 16, 2021 Category: Internal Medicine Authors: Tsagkaris C, Mohanan P Tags: Eur J Intern Med Source Type: research

Mechanisms of weight regain.
Abstract Weight regain following weight loss is frequent problem that people with obesity face. This weight recidivism is often attributed to the lack of compliance with appropriate food habits and exercise. On the contrary, it is known that body weight and fat mass are regulated by numerous physiological mechanisms, far beyond voluntary food intake and physical exercise. Thus, the aim of this paper is to review the main peripheral and central mechanisms involved in weight regain. Gut hormone secretion profiles impact upon predisposition to weight regain according to an individual variability, although it is recog...
Source: European Journal of Internal Medicine - January 16, 2021 Category: Internal Medicine Authors: Busetto L, Bettini S, Makaronidis J, Roberts CA, Halford JCG, Batterham RL Tags: Eur J Intern Med Source Type: research

Alcoholic liver disease and autoimmune hepatitis: Sometimes a closer look under the surface is needed.
CONCLUSIONS: AIH should not be forgotten in patients with alcohol use when clinical and laboratory features hint towards the diagnosis of AIH/ALD variant as this group seems to have worse outcome compared to those with AIH alone suggesting the need for closer follow-up and surveillance. Reliable autoantibody testing and cautious interpretation of liver histology appear mandatory for AIH diagnosis in these difficult to diagnose cases. PMID: 33451888 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - January 12, 2021 Category: Internal Medicine Authors: Rigopoulou EI, Gatselis N, Arvaniti P, Koukoulis GK, Dalekos GN Tags: Eur J Intern Med Source Type: research

Validity of "Sepsis-3" criteria in identifying patients with community-onset sepsis in Internal Medicine wards; a prospective, multicenter study.
Validity of "Sepsis-3" criteria in identifying patients with community-onset sepsis in Internal Medicine wards; a prospective, multicenter study. Eur J Intern Med. 2021 Jan 12;: Authors: Fortini A, Faraone A, Meini S, Bettucchi M, Longo B, Valoriani B, Forni S, Italian Federation of Hospital Internists (FADOI) - Sepsis Collaboration Group of the Tuscany Region Abstract BACKGROUND: Few data are available on the validity of "Sepsis-3" criteria in identifying patients with sepsis in internal medicine wards (IMWs). Real-life data about this topic and on the prevalence of sepsis in IMWs...
Source: European Journal of Internal Medicine - January 12, 2021 Category: Internal Medicine Authors: Fortini A, Faraone A, Meini S, Bettucchi M, Longo B, Valoriani B, Forni S, Italian Federation of Hospital Internists (FADOI) - Sepsis Collaboration Group of the Tuscany Region Tags: Eur J Intern Med Source Type: research

Cardiac imaging in heart failure in the personalized medicine era: Pathway to knowledge or Tiresias' paradox?
Abstract Tiresias was the blind prophet of Apollo in Thebes. Tiresias is a symbolic figure, which embodies a paradox: he is blind in the physical sense, but his knowledge surpasses all, as opposed to Oedipus who cannot see despite having a good eyesight. Cardiac imaging can be considered the technological extension of human eyes, which has clearly revolutionised the diagnostic approach in Cardiology and specifically in heart failure. Echocardiography contributed to an approach focused on the ejection fraction (EF) which is the cornerstone of the most recent classifications of heart failure. The recent advances in ...
Source: European Journal of Internal Medicine - January 8, 2021 Category: Internal Medicine Authors: Finocchiaro G, Carr-White G, Sinagra G Tags: Eur J Intern Med Source Type: research

The Brain-Gut-Microbiotal Axis: A framework for understanding functional GI illness and their therapeutic interventions.
Abstract Functional gastrointestinal disorders (FGIDs), characterized by chronic abdominal complaints without a structural or biochemical cause, are common diseases that are frequently encountered by specialists in internal medicine. Collectively, irritable bowel syndrome (IBS) and functional dyspepsia are estimated to affect up to 22% of the population, and are often associated with additional somatic and pain complaints, all without an obvious structural source [1,2]. An appreciation of the current understanding of the mechanistic basis for these disorders is key to developing treatment goals and optimization of...
Source: European Journal of Internal Medicine - January 7, 2021 Category: Internal Medicine Authors: Tait C, Sayuk GS Tags: Eur J Intern Med Source Type: research

Non-retrieved inferior vena cava filters: causes and long-term follow-up.
CONCLUSIONS: The main preventable cause of non-retrieval of temporary IVC filters was lack of planning / follow-up. Structured follow-up programs should be implemented to increase retrieval rates. In patients with indwelling filters, the main cause of death was cancer and extended anticoagulation was not associated with survival. PMID: 33422388 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - January 6, 2021 Category: Internal Medicine Authors: Ribas J, Alba E, Pascual-González Y, Ruíz Y, Iriarte A, Mora-Luján JM, Valcárcel J, Corbella X, Santos S, Escalante E, Riera-Mestre A Tags: Eur J Intern Med Source Type: research

Proprotein Convertase Subtilisin-Kexin Type 9 inhibitors and stroke prevention: A meta-analysis.
PMID: 33419661 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - January 5, 2021 Category: Internal Medicine Authors: Sagris D, Ntaios G, Georgiopoulos G, Pateras K, Milionis H Tags: Eur J Intern Med Source Type: research

Sex, age and venous thrombosis-Are men and women indeed from different planets?
PMID: 33419662 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - January 5, 2021 Category: Internal Medicine Authors: Eichinger S, Kyrle PA Tags: Eur J Intern Med Source Type: research

Mid-day sleep and blood pressure in patients with arterial hypertension. Author's reply.
PMID: 33419663 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - January 5, 2021 Category: Internal Medicine Authors: Kallistratos MS, Poulimenos LE, Manolis AJ Tags: Eur J Intern Med Source Type: research

Predictors of mortality among adult, old and the oldest old patients with bloodstream infections: An age comparison.
Abstract BACKGROUND: Bloodstream infections (BSIs) are a major cause of mortality in elderly. Objective of the study is to identify factors predictive of mortality in old and oldest old patients. METHODS: This is a single centre retrospective observational study, including all patients admitted to Fondazione Policlinico A. Gemelli university hospital and diagnosed with BSI. Patients were stratified into three groups according to age: adult (A), younger than 65; old (O), aged between 65 and 80; oldest old (OO), older than 80. Primary outcome was 30-day in-hospital mortality. Secondary outcomes were duration of...
Source: European Journal of Internal Medicine - January 4, 2021 Category: Internal Medicine Authors: Giovannenze F, Murri R, Palazzolo C, Taccari F, Camici M, Spanu T, Posteraro B, Sanguinetti M, Cauda R, Onder G, Fantoni M Tags: Eur J Intern Med Source Type: research

Long-term outcomes of postoperative atrial fibrillation following non cardiac surgery: A systematic review and metanalysis.
CONCLUSIONS: POAF is associated with a greater risk of stroke and mortality over the long-term period. Studies focusing on AF recurrence are needed to address the perception of POAF as a benign transient entity. The increased mortality risk following POAF should encourage systematic detection and prevention of this arrhythmia. PMID: 33402281 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - January 2, 2021 Category: Internal Medicine Authors: Albini A, Malavasi VL, Vitolo M, Imberti JF, Marietta M, Lip GYH, Boriani G Tags: Eur J Intern Med Source Type: research

Heart rate turbulence in obstructive sleep apnea syndrome: The effect of short-term CPAP therapy.
PMID: 33390320 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - December 31, 2020 Category: Internal Medicine Authors: D'Addio G, De Felice A, Donisi L, Braghiroli A, Maniscalco M Tags: Eur J Intern Med Source Type: research

Associating enterococcal endocarditis and colorectal neoplasia: is colonoscopy mandatory? - Authors' reply.
i MP, Zampino R, Durante-Mangoni E PMID: 33390321 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - December 31, 2020 Category: Internal Medicine Authors: Authors' reply. Tags: Eur J Intern Med Source Type: research

Efficacy and safety of rituximab biosimilar (CT-P10) in IgG4-related disease: an observational prospective open-label cohort study.
Abstract OBJECTIVE: Rituximab is increasingly used in IgG4-related disease (IgG4-RD) but high costs limit its wide off-label administration. European and US regulatory agencies have recently approved rituximab biosimilars for the treatment of different rheumatologic and hematological conditions. No data are available, yet, on the efficacy and safety of rituximab biosimilars for the treatment of IgG4-RD. Scope of the present work is to evaluate the efficacy and safety of the rituximab biosimilar CT-P10 (RTX-B) in patients with IgG4-RD. METHODS: Patients with active IgG4-RD, naïve to rituximab or switched ...
Source: European Journal of Internal Medicine - December 29, 2020 Category: Internal Medicine Authors: Della-Torre E, Lanzillotta M, Campochiaro C, Di-Colo G, Mancuso G, Capurso G, Falconi M, Dagna L Tags: Eur J Intern Med Source Type: research