Associations between early handoffs, length of stay and complications in internal medicine wards: A retrospective study.
Abstract BACKGROUND: In US healthcare system, handoffs are associated with an increase in medical error and in hospital length of stay. In non-US healthcare systems, this phenomenon has not been well studied. We studied the association between early handoffs (EH) in a non-US internal medicine ward with length of stay (LOS), use of resources, major complication (MC) and discharge to post-acute care (PAC) facility. METHODS: We conducted a retrospective cohort study on patients admitted to the general internal medicine division. Patients with EH (defined as a transfer of responsibility between primary teams with...
Source: European Journal of Internal Medicine - July 13, 2019 Category: Internal Medicine Authors: Fehlmann C, Louis Simonet M, Reny JL, Stirnemann J, Blondon K Tags: Eur J Intern Med Source Type: research

Blood eosinophils as biomarkers of therapeutic response to chronic obstructive pulmonary disease: Still work in progress.
Abstract Disease phenotyping is a key step towards an increasingly personalized approach to chronic obstructive pulmonary disease (COPD), leading to a more precise assessment, treatment and definition of disease outcomes. The search for biomarkers able to guide the identification of COPD phenotypes are of great importance for both researchers and clinicians. However, while several biomarkers of inflammation [e.g., peripheral blood eosinophils and fractional expired nitric oxide] have been identified and applied in asthma, none has been successfully linked to discrete clinical parameters of COPD such as exacerbatio...
Source: European Journal of Internal Medicine - July 12, 2019 Category: Internal Medicine Authors: Fuschillo S, Molino A, Stellato C, Motta A, Maniscalco M Tags: Eur J Intern Med Source Type: research

The cost-effectiveness of omega-3 polyunsaturated fatty acids - The Australian healthcare perspective.
CONCLUSIONS: Patients with established CVD in whom level of triglycerides is high would benefit from the treatment using icosapent ethyl, however, it is not a cost-effective from an Australian healthcare system perspective. The government may consider subsidising this medication given the clinical need but at a discounted acquisition cost. PMID: 31285124 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - July 6, 2019 Category: Internal Medicine Authors: Gao L, Moodie M, Li SC Tags: Eur J Intern Med Source Type: research

Continued evolution of hospital medicine.
PMID: 31280906 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - July 4, 2019 Category: Internal Medicine Authors: Merli GJ, Harrop CM Tags: Eur J Intern Med Source Type: research

Infective endocarditis in patients with cardiac implantable electronic devices: Impact of comorbidities on outcome.
PMID: 31280907 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - July 4, 2019 Category: Internal Medicine Authors: Diemberger I, Lorenzetti S, Vitolo M, Boriani G Tags: Eur J Intern Med Source Type: research

Rituximab-induced serum sickness is more frequent in autoimmune diseases as compared to hematological malignancies: A French nationwide study.
CONCLUSION: Patients generally recovered from RISS rapidly without obvious benefit from corticosteroid therapy. The risk of recurrence should prompt clinicians to question the use of rituximab after an episode of RISS. PMID: 31279430 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - July 3, 2019 Category: Internal Medicine Authors: Bayer G, Agier MS, Lioger B, Lepelley M, Zenut M, Lanoue MC, Maillot F, Jonville-Bera AP Tags: Eur J Intern Med Source Type: research

Porphyrias: A clinically based approach.
CONCLUSIONS: Porphyrias can be divided based on clinical presentation in acute neurovisceral, chronic cutaneous bullous, chronic cutaneous non-bullous and acute neurovisceral/chronic cutaneous bullous. Each individual porphyria presents a characteristic pattern of porphyrins in plasma, urine, stool and red blood cells. As such, diagnosis is easily obtained by following a simple diagnostic algorithm. Early recognition is key in managing these diseases. Neurovisceral porphyrias require acute support therapy and chronic eviction of precipitating factors. Cutaneous prophyrias, as photosensitivity disorders, rely on sunlight av...
Source: European Journal of Internal Medicine - June 27, 2019 Category: Internal Medicine Authors: Rigor J, Pinto SA, Martins-Mendes D Tags: Eur J Intern Med Source Type: research

Skin autofluorescence as a tool for cardiovascular risk estimation in patients with rheumatoid arthritis.
PMID: 31253386 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - June 25, 2019 Category: Internal Medicine Authors: Bakker-Aling SH, van Woerkom JM, Zomer TP, Buscher HCJL, van Bemmel T Tags: Eur J Intern Med Source Type: research

Patients with acute pulmonary embolism at intermediate risk for death: Can we further stratify?
PMID: 31248737 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - June 24, 2019 Category: Internal Medicine Authors: Becattini C, Cimini LA, Vedovati MC Tags: Eur J Intern Med Source Type: research

Lung ultrasonography in pulmonary tuberculosis: A pilot study on diagnostic accuracy in a high-risk population.
Abstract OBJECTIVES: The validity of lung ultrasound (LUS) in the diagnosis of interstitial or focal lung pathologies is well documented, we assessed its accuracy in the diagnosis of pulmonary tuberculosis (PTB). METHODS: Sonographic signs suggestive of PTB and their diagnostic accuracy were evaluated in patients admitted with clinical suspicion of PTB. Consolidations, subpleural nodules, pleural thickenings or irregularities and pleural effusion were assessed. LUS signs significantly associated with PTB in the univariate analysis (p 
Source: European Journal of Internal Medicine - June 21, 2019 Category: Internal Medicine Authors: Montuori M, Casella F, Casazza G, Franzetti F, Pini P, Invernizzi C, Torzillo D, Rizzardini G, Galli M, Cogliati C Tags: Eur J Intern Med Source Type: research

Does my patient really need this at admission? Seven opportunities for improving value in patient care during their hospitalization.
CONCLUSION: These results demonstrate that there is ample room for reduction of low-value care. Interventions to implement clinical guidelines at admissions should be addressed to cover the entire admission process, from the emergency room to the ward. Partial approaches are discouraged. PMID: 31230851 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - June 20, 2019 Category: Internal Medicine Authors: Corral-Gudino L, Rivas-Lamazares A, González-Fernández A, Rodríguez-María M, Aguilera-Sanz C, Tierra-Rodríguez A, Runza-Buznego P, Hernández-Martín E, Ortega-Gil M, Bahamonde-Carrasco A Tags: Eur J Intern Med Source Type: research

Increased risk of venous thromboembolism among patients with hyperthyroidism: a systematic review and meta-analysis of cohort studies.
CONCLUSION: A significantly increased risk of incident VTE among patients with hyperthyroidism compared to individuals without hyperthyroidism was demonstrated in this meta-analysis. PMID: 31229403 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - June 19, 2019 Category: Internal Medicine Authors: Srisawat S, Sitasuwan T, Ungprasert P Tags: Eur J Intern Med Source Type: research

An update on IgG4-related lung disease.
Abstract IgG4-related disease (IgG4-RD) is an autoimmune disorder characterized by substantial infiltration of plasma cells with IgG4 in target organs. Lung manifestations predominantly present as inflammatory pseudotumor, interstitial pneumonitis, organizing pneumonia, and lymphomatoid granulomatosis. There is no specific diagnostic test for IgG4-related lung disease (IgG4-RLD), and excluding diseases that mimic IgG4-RLD is important. Corticosteroids with or without disease-modifying anti-rheumatic drugs are recommended for treatment. The long-term prognosis of IgG4-RLD remains unknown. In this review, we summari...
Source: European Journal of Internal Medicine - June 19, 2019 Category: Internal Medicine Authors: Morales AT, Cignarella AG, Jabeen IS, Barkin JS, Mirsaeidi M Tags: Eur J Intern Med Source Type: research

Short-term effects of direct-acting antiviral agents on inflammation and gut microbiota in hepatitis C-infected patients.
AM, Sánchez SC, Morano LE, Oteo JA Abstract Liver damage is associated with gut dysbiosis. New direct-acting antiviral agents (DAAs) are able to eradicate hepatitis C virus (HCV) from the body. However, the short and medium-term effects of DAAs at gut level before advanced liver damage occurs have not been evaluated yet. Thus, we investigated the impact of HCV and DAAs on gut microbiota composition (GM) and systemic inflammation. To achieve this objective, twenty-three non HCV-infected controls and 22 HCV-infected patients were recruited. Only non-cirrhotic patients (fibrosis stage 0-3) were included to avo...
Source: European Journal of Internal Medicine - June 17, 2019 Category: Internal Medicine Authors: Pérez-Matute P, Íñiguez M, Villanueva-Millán MJ, Recio-Fernández E, Vázquez AM, Sánchez SC, Morano LE, Oteo JA Tags: Eur J Intern Med Source Type: research

Vedolizumab is effective and safe in real-life treatment of inflammatory bowel diseases outpatients: A multicenter, observational study in primary inflammatory bowel disease centers.
CONCLUSION: VDZ is effective and safe in IBD outpatients, especially in UC patients. PMID: 31208827 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - June 14, 2019 Category: Internal Medicine Authors: Tursi A, Mocci G, Faggiani R, Allegretta L, Valle ND, Medici A, Forti G, Franceschi M, Ferronato A, Gallina S, Grasso G, Larussa T, Luzza F, Lorenzetti R, Penna A, Rodino' S, Sebkova L, Lauria A, Piergallini S, Pranzo G, Scorza S, Zampaletta C, Picchio M, Tags: Eur J Intern Med Source Type: research

Paraneoplastic movement disorders: phenomenology, diagnosis, and treatment.
Abstract Paraneoplastic syndromes include, by definition, any symptomatic and non-metastatic condition associated with a neoplasm. Paraneoplastic movement disorders are a heterogeneous group of syndromes encompassing both hyperkinetic and hypokinetic conditions, characterized by acute/sub-acute onset, rapidly progressive evolution, and multifocal localizations with several overlapping features. These movement disorders are immune-mediated, as shown by the rapid onset and by the presence of antineuronal antibodies in biological samples of patients, fundamental for the diagnosis. Antineuronal antibodies could be tar...
Source: European Journal of Internal Medicine - June 12, 2019 Category: Internal Medicine Authors: Chirra M, Marsili L, Gallerini S, Keeling EG, Marconi R, Colosimo C Tags: Eur J Intern Med Source Type: research

Cardiac autonomic modulation at rest and during orthostatic stress among different systemic sclerosis subsets.
CONCLUSION: SSc showed a reduced vagal and increased sympathetic modulation at rest and a blunted autonomic response to ORT in comparison to HC. These alterations were mostly detectable in the advanced and fibrotic forms of SSc (dcSSc and lcSSc), while EaSSc were similar to HC. PMID: 31202484 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - June 12, 2019 Category: Internal Medicine Authors: Rodrigues GD, Tobaldini E, Bellocchi C, Santaniello A, Caronni M, Severino A, Froldi M, Beretta L, da Silva Soares PP, Montano N Tags: Eur J Intern Med Source Type: research

White islands in a sea of red: A tropical rash.
PMID: 31200995 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - June 11, 2019 Category: Internal Medicine Authors: Lucero JA, Sacdalan DB Tags: Eur J Intern Med Source Type: research

ST-elevation myocardial infarction in a real world population - An observational retrospective study with a sex perspective.
Abstract BACKGROUND: Mortality after myocardial infarction is higher in women than in men. Data on the association between sex and mortality are conflicting and inconclusive. We evaluated whether there is a sex difference in survival and if sex is associated with the outcome in patients with ST-elevation myocardial infarction (STEMI). METHODS: We analyzed 3671 STEMI patients. Long-term and 30-day mortality in men and women were compared. RESULTS: Unadjusted mortality at day 30 was higher in women [221 (8.7%) men died compared to 147 (13.1%) women; p 
Source: European Journal of Internal Medicine - June 11, 2019 Category: Internal Medicine Authors: Kanic V, Suran D, Krajnc I, Kompara G Tags: Eur J Intern Med Source Type: research

External validation of the CACE-HF risk score for mortality in patients with heart failure.
CONCLUSIONS: The results of the external validation of the CACE-HF risk score show that although the capacity for discrimination was slightly lower than in the derivation cohort, the calibration was excellent. This tool, therefore, can assist in decision-making in the management of these patients. PMID: 31196740 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - June 10, 2019 Category: Internal Medicine Authors: Quirós-López R, Manzano-Espinosa L, Bilbao A, Montero Pérez-Barquero M, Cepeda-Rodrigo JM, Escobar-Martínez A Tags: Eur J Intern Med Source Type: research

Outcomes in acute medicine - Evidence from extended observations on readmissions, hospital length of stay and mortality outcomes.
Abstract BACKGROUND: The Acute Medical Admission Unit (AMAU) model of care has been widely deployed, we examine changes in hospital readmission rates, length of stay (LOS) and 30-day in-hospital mortality over 16 years. METHODS: All emergency medical admissions between 2002 and 2017 were examined. We assessed 30-day in-hospital mortality, readmission rates, and LOS using logistic regression and margins statistics modelled outcomes against predictor variables. RESULTS: There were 106,586 admissions in 54,928 patients over 16 years. Calculated per patient the 30-day in-hospital mortality was 8.9% (95%C...
Source: European Journal of Internal Medicine - June 10, 2019 Category: Internal Medicine Authors: Conway R, Byrne D, O'Riordan D, Silke B Tags: Eur J Intern Med Source Type: research

JAK inhibitors in 2019, synthetic review in 10 points.
Abstract JAK inhibitors are recent treatments. Many publications have appeared in recent years, exposing treatment efficiencies in phases 2 and 3 studies, or their tolerance profile in various rheumatological diseases. We propose here a systematic review of JAK inhibitors, from their mechanism of physiological action up to the estimation of their current risk benefit balance, and their possible future applications. In order to better synthesize the data, we organized this review into 10 essential points. 1- What is the role of JAK/Stat pathway? 2- How can a single signaling pathway regulate as many different signa...
Source: European Journal of Internal Medicine - June 6, 2019 Category: Internal Medicine Authors: Muller R Tags: Eur J Intern Med Source Type: research

An atypical cause of dyspnea.
PMID: 31176526 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - June 5, 2019 Category: Internal Medicine Authors: Kaeuffer C, Ledoux MP, Herbrecht R Tags: Eur J Intern Med Source Type: research

Associations between patient and system characteristics and MET review within 48  h of admission to a teaching hospital: A retrospective cohort study.
CONCLUSIONS: This is the first study to demonstrate the potential to predict clinical deterioration using data that is readily accessible at the time of admission to hospital. PMID: 31155230 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 30, 2019 Category: Internal Medicine Authors: Allen J, Orellana L, Jones D, Considine J, Currey J Tags: Eur J Intern Med Source Type: research

Delirium in patients with dementia and in children: Overlap of symptoms profile and possible role for future diagnosis.
Abstract BACKGROUND: Delirium in the extremes of the age spectrum may show similarities in presentations, and these similarities may provide information to develop tools for the diagnosis of delirium superimposed on dementia (DSD). We sought to investigate the symptom profile and subtypes of delirium in patients with dementia, and in infants and preschool children. METHODS: This was an exploratory analysis of previous prospective cohort studies that evaluated delirium with the DSM-IV criteria in patients with dementia, and in critically ill infants (
Source: European Journal of Internal Medicine - May 28, 2019 Category: Internal Medicine Authors: Morandi A, Thompson JL, Bellelli G, Lucchi E, Turco R, Gentile S, Trabucchi M, MacLullich A, Meagher D, Ely EW, Pandharipande P, Smith H Tags: Eur J Intern Med Source Type: research

Spontaneous pneumomediastinum presententing as nasal voice.
PMID: 31138480 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 25, 2019 Category: Internal Medicine Authors: Miller A, Mann Ben Yehuda T Tags: Eur J Intern Med Source Type: research

A refractory bicytopenia in a pregnant woman.
PMID: 31133462 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 24, 2019 Category: Internal Medicine Authors: Gerfaud-Valentin M, Chaudot F, Seve P Tags: Eur J Intern Med Source Type: research

Multimodality imaging of aortopulmonary paraganglioma.
PMID: 31128975 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 23, 2019 Category: Internal Medicine Authors: Melillo F, Spoladore R, Margonato A Tags: Eur J Intern Med Source Type: research

And now we have the AUGUSTUS … How will it impact on antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention?
And now we have the AUGUSTUS … How will it impact on antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention? Eur J Intern Med. 2019 May 23;: Authors: Rubboli A PMID: 31130303 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 23, 2019 Category: Internal Medicine Authors: Rubboli A Tags: Eur J Intern Med Source Type: research

New oncologic emergencies: What is there to know about inmunotherapy and its potential side effects?
so-Gordoa T Abstract Over the last decade anticancer treatment has experienced encouraging changes. One of the latest developments is immunotherapy, which is increasingly becoming a mainstay for the treatment of these malignancies. Unlike conventional chemotherapy, immunotherapy enhances anti-tumor immune response by blocking inhibitory immune checkpoints, and allowing our own immune system to fight against the tumor cells, arising as a new and innovative mechanism of action. Therefore, although well tolerated, these drugs have a unique side effect profile and are known to cause immune-related adverse events (irAE...
Source: European Journal of Internal Medicine - May 23, 2019 Category: Internal Medicine Authors: Barquín-García A, Molina-Cerrillo J, Garrido P, Garcia-Palos D, Carrato A, Alonso-Gordoa T Tags: Eur J Intern Med Source Type: research

Predictors of mortality of bloodstream infections among internal medicine patients in a Swiss Hospital: Role of quick Sequential Organ Failure Assessment.
CONCLUSION: qSOFA as compared to other severity scores showed an excellent negative predictive value. Better prognosis was associated with administration of appropriate empiric antibiotic therapy and its timely initiation. PMID: 31128976 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 22, 2019 Category: Internal Medicine Authors: Papadimitriou-Olivgeris M, Psychogiou R, Garessus J, Camaret A, Fourre N, Kanagaratnam S, Jecker V, Nusbaumer C, Monnerat LB, Kocher A, Portillo V, Duplain H Tags: Eur J Intern Med Source Type: research

Navigating the treacherous waters of antithrombotic therapies in patients with atrial fibrillation and coronary artery disease: Lessons from AUGUSTUS.
PMID: 31128977 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 22, 2019 Category: Internal Medicine Authors: Harskamp RE, Alexander JH, Lopes RD Tags: Eur J Intern Med Source Type: research

CD5/CD20 expression on circulating B cells in HCV-related chronic hepatitis and mixed cryoglobulinemia.
CONCLUSIONS: The occurrence of a CLL-like pattern may allow to identify HCV-infected patients at risk of developing MC and eventually non-Hodgkin lymphoma, who should require a closer surveillance and a longer follow-up. PMID: 31126779 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 21, 2019 Category: Internal Medicine Authors: Russi S, Vincenti A, Vinella A, Mariggiò MA, Pavone F, Dammacco F, Lauletta G Tags: Eur J Intern Med Source Type: research

Body mass index as a driver of selection of biologic therapy in rheumatoid arthritis. Results from the US-CLARA study.
CONCLUSIONS: BMI does not influence the abatacept response in RA patients with active disease. During abatacept treatment, the clinical response can be achieved despite a condition of overweight or obesity. PMID: 31113709 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 18, 2019 Category: Internal Medicine Authors: Di Carlo M, Salaffi F, Gremese E, Iannone F, Lapadula G, Ferraccioli G, GISEA Study Group Tags: Eur J Intern Med Source Type: research

A quarter of admitted poisoned patients have a mild poisoning and require no treatment: An observational study.
CONCLUSIONS: The majority of poisoned patients presented to the ED was admitted, while in retrospect, a quarter of these admissions were uneventful. Predictive parameters should be sought to identify patients who can be sent home safely. PMID: 31113710 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 18, 2019 Category: Internal Medicine Authors: Hondebrink L, Rietjens SJ, Donker DW, Hunault CC, van den Hengel-Koot I, Verputten PM, de Vries I, Kaasjager KAH, Dekker D, de Lange DW Tags: Eur J Intern Med Source Type: research

Management of iron deficiency in chronic heart failure: Practical considerations for clinical use and future directions.
Abstract Heart Failure (HF) is a global pandemic with rapidly increasing prevalence. In an attempt to maintain patients well being, the therapeutic interest has expanded to the vicious cycles that confer to HF mortality and morbidity and a number of comorbidities have been targeted. Iron deficiency represents a common comorbid condition that affects outcomes in HF. The treatment of iron deficiency is strongly supported by the cardiologic societies all over the world. Intravenous iron, primarily ferric carboxymaltose, has shown clinical benefit in this setting, irrespective of the anemia status. Practical recommend...
Source: European Journal of Internal Medicine - May 17, 2019 Category: Internal Medicine Authors: Nikolaou M, Chrysohoou C, Georgilas TA, Giamouzis G, Giannakoulas G, Karavidas A, Papadopoulos C, Patsilinakos S, Tziakas D, Parissis J, Hellenic Iron Consensus Group Tags: Eur J Intern Med Source Type: research

An unusual cause of ventricular tachycardia.
PMID: 31109848 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 17, 2019 Category: Internal Medicine Authors: Zuin M, Roncon L Tags: Eur J Intern Med Source Type: research

Hereditary angioedema, emergency management of attacks by a call center.
Abstract OBJECTIVE: Hereditary angiœdema (HAE) is a rare autosomal dominant disease characterized by recurrent, unpredictable, potentially life-threatening swelling. Objective is to assess the management of the acute HAE attacks in the real life setting through a call center in France. METHODS: A pre-specified ancillary study of SOS-HAE, a cluster-randomized prospective multicenter trial, was conducted. HAE patients were recruited from 8 participating reference centers. The outcome of interest was the rate of hospitalization. RESULTS: onerhundred patients were included. The median (quartile) age wa...
Source: European Journal of Internal Medicine - May 17, 2019 Category: Internal Medicine Authors: Javaud N, Altar A, Fain O, Reuter PG, Desmaizieres M, Petrovic T, Ghazali A, Durand-Zaleski I, Bouillet L, Vicaut E, Launay D, Martin L, Floccard B, Gompel A, Sobel A, Boccon-Gibod I, Kanny G, Lapostolle F, Adnet F Tags: Eur J Intern Med Source Type: research

Sparse pustules and tenosynovitis in a young man.
via J PMID: 31109850 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 17, 2019 Category: Internal Medicine Authors: Torres-Navarro I, de Unamuno-Bustos B, López-Davia J Tags: Eur J Intern Med Source Type: research

Author's Reply: Issues regarding ambulatory blood pressure measurement in severely obese population: The guilty upper-arm' Item cover sheet has been updated accordingly.
PMID: 31109851 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 17, 2019 Category: Internal Medicine Authors: Głuszewska A, Gryglewska B, Gąsowski J Tags: Eur J Intern Med Source Type: research

Burning red hot feet.
PMID: 31104974 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 16, 2019 Category: Internal Medicine Authors: Thakur V, De D Tags: Eur J Intern Med Source Type: research

Pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension incidence in Latvia in 2018.
PMID: 31101467 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 14, 2019 Category: Internal Medicine Authors: Kigitovica D, Sablinskis M, Sablinskis K, Rudzitis A, Skride A Tags: Eur J Intern Med Source Type: research

Prognosis after pacemaker implantation in extreme elderly.
Abstract AIMS: Significant comorbidities may limit the potential benefit of pacemaker (PM) implantation in extreme elderly. A short-term mortality risk prediction score, able to identify high-risk patients, may be a useful tool in this population. METHODS AND RESULTS: We retrospectively analyzed 538 patients aged>80 years at the time of implant who underwent PM implantation. Kaplan-Meier survival and multivariable Cox regression analyses were performed to identify patient, procedural or complication variables predictive of death. The ACP (Aging in Cardiac Pacing) Score was constructed by assigning weight...
Source: European Journal of Internal Medicine - May 13, 2019 Category: Internal Medicine Authors: Cristina B, Michele M, Fabio F, Matteo G, Fatima Z, Alessandro B, Vittorio S, Roberto F, Matteo B Tags: Eur J Intern Med Source Type: research

Drug-drug interactions involving CYP3A4 and p-glycoprotein in hospitalized elderly patients.
In conclusion, hospital admission is associated with an increased prevalence, but also a changing pattern of interactions concerning CYP3A4 and P-gp in elderly. Educational strategies and appropriate use of dedicated software seem desirable to limit drug interactions and the inherent risk of adverse events in older patients. PMID: 31084979 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 10, 2019 Category: Internal Medicine Authors: Gallo P, De Vincentis A, Pedone C, Nobili A, Tettamanti M, Gentilucci UV, Picardi A, Mannucci PM, Incalzi RA, REPOSI Investigators Tags: Eur J Intern Med Source Type: research

A robust tool for recording pharmacist's interventions in a low-resource setting.
PMID: 31079935 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 9, 2019 Category: Internal Medicine Authors: Rennie T, Anguuo L, Corkhill N, Mubita M, Hunter CJ Tags: Eur J Intern Med Source Type: research

Effect of risk of malnutrition on 30-day mortality among older patients with acute heart failure in Emergency Departments.
The objective was to determine the impact of risk of malnutrition on 30-day mortality risk among older patients who attended in Emergency Departments (EDs) for AHF. MATERIAL AND METHODS: We performed a secondary analysis of the OAK-3 Registry including all consecutive patients ≥65 years attending in 16 Spanish EDs for AHF. Risk of malnutrition was defined by the Mini Nutritional Assessment Short Form (MNA-SF) 
Source: European Journal of Internal Medicine - May 7, 2019 Category: Internal Medicine Authors: Martín-Sánchez FJ, Cuesta Triana F, Rossello X, Pardo García R, Llopis García G, Caimari F, Vidán MT, Ruiz Artacho P, González Del Castillo J, Llorens P, Herrero P, Jacob J, Gil V, Fernández Pérez C, Gil P, Bueno H, Miró Ò, Matía Martín P, Rep Tags: Eur J Intern Med Source Type: research

Systematic review and meta-analysis of randomised controlled clinical trial evidence refutes relationship between pharmacotherapy with angiotensin-receptor blockers and an increased risk of cancer.
CONCLUSIONS: The results of our meta-analysis focusing only on high evidence levels and study designs (RCTs) did not reveal any relationship between pharmacotherapy with an ARB and an increased risk for cancer in general. PMID: 31060961 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 3, 2019 Category: Internal Medicine Authors: Datzmann T, Fuchs S, Andree D, Hohenstein B, Schmitt J, Schindler C Tags: Eur J Intern Med Source Type: research

Plasma level of soluble urokinase plasminogen activator receptor (suPAR) predicts long-term mortality after first acute alcohol-induced pancreatitis.
CONCLUSIONS: P-suPAR level on admission or after recovery of the first AAP does not predict the recurrence of AAP during long-term follow-up. However, P-suPAR ≥3.4 mg/mL measured after recovery from first AAP is associated with an increased risk of 10-year mortality as an independent factor. This can be used to detect patients with highest risk after AAP, in order to focus the preventive healthcare actions. PMID: 31060962 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 3, 2019 Category: Internal Medicine Authors: Aronen A, Aittoniemi J, Huttunen R, Nikkola A, Nikkola J, Limnell O, Nordback I, Sand J, Laukkarinen J Tags: Eur J Intern Med Source Type: research

Predictive value of serum myostatin for the severity and clinical outcome of heart failure.
In this study, we investigated the association between serum myostatin and the severity and prognosis in patients with CHF. METHODS: Two hundred and eighty-eight CHF patients and 62 healthy controls were studied. Cardiac ultrasound and serum myostatin, N-terminal pro-B-type natriuretic peptide (NT-proBNP) and other parameters were detected. CHF patients were divided into 3 groups according to tertiles of NT-proBNP or myostatin levels respectively. RESULTS: Serum myostatin levels were higher in CHF patients than in controls. New York Heart Association (NYHA) class IV patients had the highest levels of serum myosta...
Source: European Journal of Internal Medicine - May 2, 2019 Category: Internal Medicine Authors: Chen P, Liu Z, Luo Y, Chen L, Li S, Pan Y, Lei X, Wu D, Xu D Tags: Eur J Intern Med Source Type: research

Intermediate-risk pulmonary embolism: Aiming to improve patient stratification.
Abstract BACKGROUND: Intermediate-risk pulmonary embolism (PE) patients present a therapeutic dilemma. While some are at risk for developing adverse events, possibly requiring escalation therapy, most will have a benign course. Our aim was to define predictors which will identify those patients who will not deteriorate despite the presence of RV involvement. METHODS: We evaluated 179 consecutive intermediate-risk PE patients (47% males; mean age: 66 ± 16 years), allocating them to those who did and did not need escalation therapy and evaluating the predictors for deterioration. We then formulated...
Source: European Journal of Internal Medicine - May 1, 2019 Category: Internal Medicine Authors: Beigel R, Mazin I, Goitein O, Herscovici R, Natanzon S, Chernomordik F, Ben-Zekry S, Fefer P, Grupper A, Matetzky S Tags: Eur J Intern Med Source Type: research