Excellent Safety and Sustained Virologic Response to Direct-Acting Antivirals Treatment in HCV-Infected Geriatric Patients: A Real-World Data
ConclusionBased on our real-world data, geriatric patients had excellent and comparable treatment outcomes with non-geriatric patients in safety and SVR12 rates to different DAA regimens. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 13, 2020 Category: Gastroenterology Source Type: research

High-Resolution Colonic Manometry Pressure Profiles Are Similar in Asymptomatic Diverticulosis and Controls
ConclusionsIn this first high-resolution colonic manometry study of patients with diverticular disease, we did not find evidence for increased manometric pressures or increased colonic activity in patients with diverticular disease. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 12, 2020 Category: Gastroenterology Source Type: research

BBOX1-AS1 Accelerates Gastric Cancer Proliferation by Sponging miR-3940-3p to Upregulate BIRC5 Expression
ConclusionsBBOX1-AS1 accelerates GC proliferation by sponging miR-3940-3p to upregulate BIRC5 expression, which may guide a new direction into the therapeutic strategies of GC. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 11, 2020 Category: Gastroenterology Source Type: research

Tangled Up in Red Cells: A Large Liver Mass with Intravascular Hemolysis
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 11, 2020 Category: Gastroenterology Source Type: research

Correction to: Hyperbaric Oxygen Ameliorated Acute Pancreatitis in Rats via the Mitochondrial Pathway
The original version of the article unfortunately contained an error in the legend of Figure  2b and 2c. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 9, 2020 Category: Gastroenterology Source Type: research

Cost –Utility of All-Oral Direct-Acting Antiviral Regimens for the Treatment of Genotype 1 Chronic Hepatitis C Virus-Infected Patients in Hong Kong
ConclusionsDAAs can be a cost-effective option for the treatment of genotype 1 HCV patients in Hong Kong, and elbasvir/grazoprevir is cost-effective. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 8, 2020 Category: Gastroenterology Source Type: research

A Commentary on the Interplay Between Severity of Liver Disease and Bacterial Infection in Hospitalized Patients with Cirrhosis
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 8, 2020 Category: Gastroenterology Source Type: research

Author Spotlight: Kelly E. Hathorn
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 8, 2020 Category: Gastroenterology Source Type: research

Hot Pockets: The Adverse Admixture of Obesity and Diverticulitis
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 7, 2020 Category: Gastroenterology Source Type: research

Does Obesity Affect Outcomes of Transjugular Intrahepatic Portosystemic Shunt Placement?
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 6, 2020 Category: Gastroenterology Source Type: research

Author Spotlight: Liat Gutin
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 6, 2020 Category: Gastroenterology Source Type: research

G-Protein-Coupled Receptors 120 Agonist III Improves Hepatic Inflammation and ER Stress in Steatohepatitis
ConclusionGPR120 agonist III will be an attractive treatment method in steatohepatitis, which opens up a new sight for future treatments of human NAFLD/NASH. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 5, 2020 Category: Gastroenterology Source Type: research

Author Spotlight: Mohammad Bilal
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 5, 2020 Category: Gastroenterology Source Type: research

Author Spotlight: Joel Gabre
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 5, 2020 Category: Gastroenterology Source Type: research

Low Epstein –Barr Virus Prevalence in Cardia Gastric Cancer Among a High-Incidence Chinese Population
AbstractBackgroundEpstein –Barr virus (EBV) positivity is associated with better gastric cancer prognosis and is found in a relatively fixed 9% of tumors worldwide.AimWe aimed to examine the EBV status of gastric adenocarcinomas in a very high-incidence population and to compare prevalence between cardia and non-cardia anatomic subsites.MethodsWe evaluated 1035 adult gastric adenocarcinoma cases presenting during 1997 –2005 to the Shanxi Cancer Hospital in Taiyuan, Shanxi Province, China. EBV-encoded RNA was detected in alcohol-fixed paraffin-embedded tumor specimens by in situ hybridization. Associations were ...
Source: Digestive Diseases and Sciences - May 4, 2020 Category: Gastroenterology Source Type: research

Going Viral: Management of IBD in the Era of the COVID-19 Pandemic
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 4, 2020 Category: Gastroenterology Source Type: research

Linked Color Imaging Can Improve Detection Rate of Early Gastric Cancer in a High-Risk Population: A Multi-Center Randomized Controlled Clinical Trial
AbstractBackgroundEarly diagnosis of gastric cancer is difficult in China due to the lack of a valid method for endoscopic screening. Early gastric cancer, especially flat gastric cancer, lacks specific endoscopic features. Many cases appear to be similar to ordinary gastritis cases under normal white light endoscopy, which can lead to misdiagnosis.AimsIn order to find a new method to improve detection rate of early gastric cancer in China, we designed a trial to validate linked color imaging (LCI) for screening of early gastric cancer in a high-risk population, as compared to white light imaging (WLI).MethodSubjects were ...
Source: Digestive Diseases and Sciences - May 4, 2020 Category: Gastroenterology Source Type: research

Author Spotlight: Nikki Duong
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 4, 2020 Category: Gastroenterology Source Type: research

Author Spotlight: Elizabeth S. Aby
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 4, 2020 Category: Gastroenterology Source Type: research

Antioxidant Analogue 6-Amino-2,4,5-Trimethylpyridin-3-ol Ameliorates Experimental Colitis in Mice
ConclusionsThis study demonstrated that BJ-1108 ameliorated intestinal inflammation in an experimental colitis mouse model, suggesting possible therapeutic implications for IBD. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 2, 2020 Category: Gastroenterology Source Type: research

Utilizing Google Trends to Assess Worldwide Interest in Irritable Bowel Syndrome and Commonly Associated Treatments
ConclusionsGoogle Trends is a novel tool that can complement traditional epidemiological methods in gastrointestinal disease. Future research is needed to assess its utility and accuracy as a measure of disease burden across different gastrointestinal diseases. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 2, 2020 Category: Gastroenterology Source Type: research

Chronic Pancreatitis Patients Who Leave Against Medical Advice: Prevalence, Trend, and Predictors
ConclusionLAMA occurs in approximately 1 in 29 patients with CP and is increasing at almost quadruple the rate of those without. Clinicians need to pay closer attention to the identified at-risk groups for ameliorative targeted interventions. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - May 2, 2020 Category: Gastroenterology Source Type: research

In Vitro Anti-hepatoma Activities of Notoginsenoside R1 Through Downregulation of Tumor Promoter miR-21
ConclusionsNG-R1 exerted anti-hepatoma activity through inactivation of the PI3K/Akt pathway by downregulating miR-21, contributing to further understanding of the anti-tumor activities of NG-R1 in HCC. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 14, 2020 Category: Gastroenterology Source Type: research

Initial Experience of ERCP-Guided Radiofrequency Ablation as the Primary Therapy for Inoperable Ampullary Carcinomas
ConclusionThis pilot study shows that ERCP-guided RFA is safe to use and able to reduce tumor volume and re-interventions in patients with inoperable ampullary cancer. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 14, 2020 Category: Gastroenterology Source Type: research

Limited Progress in Hepatorenal Syndrome (HRS) Reversal and Survival 2002 –2018: A Systematic Review and Meta-Analysis
ConclusionOutcomes have not improved for patients with type 1 HRS since 2002. There is a need to improve prevention and treatment of type 1 HRS. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 14, 2020 Category: Gastroenterology Source Type: research

An Unusual Culprit of Drug-Induced Pancreatitis
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 14, 2020 Category: Gastroenterology Source Type: research

Building Fences: How A20 Protects the Intestinal Mucosa in Inflammatory Bowel Diseases
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 14, 2020 Category: Gastroenterology Source Type: research

Correction to: Omega ‑3 Fatty Acids and Gut Microbiota: A Reciprocal Interaction in Nonalcoholic Fatty Liver Disease
The original version of the article is unfortunately missing the Acknowledgments section. Acknowledgments section is given below. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 14, 2020 Category: Gastroenterology Source Type: research

Selective Internal Radiation Therapy for Hepatocellular Carcinoma Across the Barcelona Clinic Liver Cancer Stages
AbstractBackgroundHepatocellular carcinoma (HCC) is the second most common lethal cancer, and there is a need for effective therapies. Selective internal radiation therapy (SIRT) has been increasingly used, but is not supported by guidelines due to a lack of solid evidence.AimsDetermine the efficacy and safety of SIRT in HCC across the Barcelona Clinic Liver Cancer (BCLC) stages A, B, and C.MethodsConsecutive patients that received SIRT between 2006 and 2016 at two centers in Canada were evaluated.ResultsWe analyzed 132 patients, 12 (9%), 62 (47%), and 58 (44%) belonged to BCLC stages A, B, and C; mean age was 61.2 (SD &th...
Source: Digestive Diseases and Sciences - April 12, 2020 Category: Gastroenterology Source Type: research

Fecal Microbiota Transplantation in Hepatitis B e Antigen-Positive Chronic Hepatitis B Patients: A Pilot Study
ConclusionsIn this non-randomized pilot study, FMT appears to be safe and potentially effective in terms of viral suppression and HBeAg clearance in patients with HBeAg-positive CHB. Further randomized controlled trials are needed in order to obtain robust conclusions. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 11, 2020 Category: Gastroenterology Source Type: research

Resuming Anticoagulation Following Hospitalization for Gastrointestinal Bleeding Is Associated with Reduced Thromboembolic Events and Improved Mortality: Results from a Systematic Review and Meta-Analysis
AbstractBackgroundSystemic anticoagulants are widely prescribed for prevention and treatment of thromboembolism, but are commonly complicated by gastrointestinal bleeding (GIB). Limited data exist on the management of anticoagulation after hospitalization for GIB and the subsequent risks of recurrent GIB, thromboembolism, and mortality.MethodsWe performed a systematic review and meta-analysis of studies to determine risk of recurrent GIB, thromboembolism, and mortality after resuming anticoagulation following GIB. PubMed, EMBASE, and Scopus were searched for randomized controlled trials and cohort studies in patients with ...
Source: Digestive Diseases and Sciences - April 11, 2020 Category: Gastroenterology Source Type: research

Strictures in Crohn ’s Disease: From Pathophysiology to Treatment
AbstractDespite recent advances aimed to treat transmural inflammation in Crohn ’s disease (CD) patients, the progression to a structuring behavior still represents an issue for clinicians. As inflammation becomes chronic and severe, the attempt to repair damaged tissue can result in an excessive production of extracellular matrix components and deposition of connective tissu e, thus favoring the formation of strictures. No specific and accurate clinical predictors or diagnostic tools for intestinal fibrosis exist, and to date, no genetic or serological marker is in routine clinical use. Therefore, intestinal fibrosi...
Source: Digestive Diseases and Sciences - April 11, 2020 Category: Gastroenterology Source Type: research

Secretory Phospholipase A2 IIa Mediates Expression of Growth Factor Receptors in Esophageal Adenocarcinoma
ConclusionssPLA2 IIa inhibition decreases EGFR and HER2 expression and lowers proliferation of human EAC. The discovery of sPLA2 IIa inhibition ’s ability to attenuate growth factor receptor signaling underscores the exciting potential of sPLA2 IIa inhibitors as therapeutics in the treatment of EAC. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 10, 2020 Category: Gastroenterology Source Type: research

Role of Extracellular Vesicles in the Diagnosis and Pathogenesis of Barrett ’s Esophagus: A Mini-Review
AbstractEsophageal adenocarcinoma (EAC) continues to be a significant public health problem with survival rates that have remained stagnant. Although the population at the highest risk for EAC, i.e., patients with Barrett ’s esophagus (BE) has been clearly defined, patients with EAC continue to do poorly due to advanced stage at diagnosis. The field of extracellular vesicles (EV) could have huge application for the management of patients with BE and EAC by allowing timely diagnosis, serial monitoring, and improved understanding of disease biology. EV are actively packaged and actively secreted vesicles and contain mi...
Source: Digestive Diseases and Sciences - April 10, 2020 Category: Gastroenterology Source Type: research

Efficacy of Single-Strain Probiotics Versus Multi-Strain Mixtures: Systematic Review of Strain and Disease Specificity
AbstractThe diversity of probiotic products makes choosing an appropriate probiotic challenging. One unanswered question is whether single-strain probiotics are more effective than multi-strain mixtures. The aim of this review is to account for both disease and strain specificity to determine whether single strains or multiple strains are equivalent or more effective. This literature review of randomized controlled trials from 1973 to 2019 was used to compare the pooled efficacy of trials with a single strain versus the probiotic mixture with same matched strain within the same type of disease indication. A total of 65 RCT...
Source: Digestive Diseases and Sciences - April 9, 2020 Category: Gastroenterology Source Type: research

Androgen Receptor Stimulates Hexokinase 2 and Induces Glycolysis by PKA/CREB Signaling in Hepatocellular Carcinoma
ConclusionsThese results indicate that AR at least partially induced glycolysis via p-CREB regulation of HK2 in HCC cells. Thus, this pathway should be considered for the design of novel therapeutic methods to target AR-overexpressing HCC. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 9, 2020 Category: Gastroenterology Source Type: research

Impacting Underserved Communities as a GI Trainee
AbstractGastroenterology fellowship programs commonly include VA and county hospitals whose patient populations consist of some of the most vulnerable and underserved populations in the country who have a multitude of socioeconomic hurdles that limit their ability to address ongoing medical issues, all while having a restricted political voice and receiving care in under-resourced clinical settings. Since trainees are integral to the care of these patients, they have available two approaches that can affect community and hospital-based change, namely quality improvement (QI) and healthcare advocacy. QI projects focused on ...
Source: Digestive Diseases and Sciences - April 9, 2020 Category: Gastroenterology Source Type: research

Know When to Hold ‘em, Know When to Treat ‘em, Know When to Cut ‘em: Why Severe Alcoholic Hepatitis Is Becoming a Surgical Disease
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 8, 2020 Category: Gastroenterology Source Type: research

Negotiating Dire Straits with a BougieCap
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 6, 2020 Category: Gastroenterology Source Type: research

Non-adherence to Medications in Pregnant Ulcerative Colitis Patients Contributes to Disease Flares and Adverse Pregnancy Outcomes
ConclusionNon-adherence to mesalamine was underestimated by physicians in pregnant UC patients and contributed to disease relapse and possibly on pregnancy outcomes. Preconceptional education regarding safety of medications and risk of self-discontinuation is warranted. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 6, 2020 Category: Gastroenterology Source Type: research

The Impact of Laparoscopic Cholecystectomy on 30-Day Readmission Rate for Acute Cholangitis Patients: A Single-Center Study
ConclusionsPerforming laparoscopic cholecystectomy during admission for acute gallstone cholangitis patients following endoscopic clearance of the bile duct significantly reduced the 30-day readmission rate without affecting the length of stay. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 4, 2020 Category: Gastroenterology Source Type: research

Healthcare Burdens Across All Gastric-Related Disorders: More Understanding, Less Impairment?
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 4, 2020 Category: Gastroenterology Source Type: research

Image Analysis of Eosinophil Peroxidase Immunohistochemistry for Diagnosis of Eosinophilic Esophagitis
The objective of this study was to evaluate image analysis of EPX immunohistochemistry as an automated method for histologic diagnosis of EoE.MethodsWe performed a secondary analysis of prospectively collected esophageal biopsies obtained from adult subjects with EoE and controls. Tissue sections were stained with hematoxylin and eosin (H&E) and evaluated for peak eosinophils per high power field (eos/hpf). The same slides were de-stained and re-stained to detect EPX for direct comparison. Slides were digitized, and EPX staining area/mm2 was quantified using image analysis. Paired samples were compared for changes in E...
Source: Digestive Diseases and Sciences - April 4, 2020 Category: Gastroenterology Source Type: research

Liver Transplantation for Alcoholic Liver Disease: Absence of Evidence for the Relevance of Abstinence
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 3, 2020 Category: Gastroenterology Source Type: research

Contribution of Splenic Resistance Arteries to Splanchnic Blood Overflow in Cirrhosis
ConclusionIn cirrhotic rats, a decreased splenic arterial response to vasoconstrictors, rather than an increased response to vasodilators, contributes to splanchnic vasodilation, while in mesenteric arteries also an increased response to vasodilators secondary to, but not only, eNOS and iNOS overexpression, plays a role. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 2, 2020 Category: Gastroenterology Source Type: research

Guidelines for Increasing Female Authorship of GI Society Guidelines
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 2, 2020 Category: Gastroenterology Source Type: research

Cholecystectomy and Biliary Sphincterotomy Increase Fecal Bile Loss and Improve Lipid Profile in Dyslipidemia
ConclusionsFecal bile acid loss increases following CS  + ES. The effect on blood lipid profile depends on baseline TC and TG levels. Lipid profile is improved in dyslipidemic patients, while the impact of CS + ES is minimal on the normolipemic population. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 19, 2020 Category: Gastroenterology Source Type: research

Comparison of Lewis Score and Capsule Endoscopy Crohn ’s Disease Activity Index in Patients with Crohn’s Disease
AbstractBackground/AimsSmall bowel capsule endoscopy (SBCE) is used to visualize mucosal inflammatory changes in the small intestine of patients with Crohn ’s disease (CD). The Lewis score (LS) and Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI) are used to evaluate the visualized images. We determined the score disagreement between LS and CECDAI in patients with CD.MethodsWe evaluated 184 SBCE procedures in 102 CD patients with small bowel lesions. Patients were classified according to the Montreal classification. LS and CECDAI were calculated, and cases with disagreement between the two scores were ...
Source: Digestive Diseases and Sciences - March 19, 2020 Category: Gastroenterology Source Type: research

Alvimopan for the Prevention of Postoperative Ileus in Inflammatory Bowel Disease Patients
AbstractBackgroundPostoperative ileus (POI) is a temporary delay of coordinated intestinal peristalsis. Alvimopan, an oral peripherally acting mu-opioid receptor antagonist approved for accelerating gastrointestinal recovery, has never been studied specifically in patients with inflammatory bowel disease (IBD).AimTo investigate the efficacy of alvimopan in preventing POI among IBD patients.MethodsA retrospective chart review was conducted on 246 IBD patients undergoing bowel surgery between 2012 and 2017. Data collected included demographics, IBD subtype, length of stay (LOS), postoperative gastrointestinal symptoms, and a...
Source: Digestive Diseases and Sciences - March 14, 2020 Category: Gastroenterology Source Type: research

Promise of Fecal Microbiota Transplantation Therapy in Pouchitis
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 14, 2020 Category: Gastroenterology Source Type: research