Adherence to Two Large-Bore Intravenous Lines in Acute Gastrointestinal Bleeding Is Low
ConclusionThe relatively simple and cost-effective intervention of placing 2LBIV lines is not often executed. We suggest that specific mention of 2LBIV placement in guidelines from national gastroenterology societies might improve compliance in this aspect. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 17, 2019 Category: Gastroenterology Source Type: research

Fragility of Life: Recurrent Intestinal Perforation Due to Vascular Ehlers –Danlos Syndrome
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 17, 2019 Category: Gastroenterology Source Type: research

Expression of Demethylase Genes, FTO and ALKBH1 , Is Associated with Prognosis of Gastric Cancer
ConclusionsAberrant expression of demethylase genes,FTO andALKBH1, has a distinct prognostic value in GC patients, indicating thatFTO andALKBH1 may play vital roles in GC progression and metastasis. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 14, 2019 Category: Gastroenterology Source Type: research

Pre-transplant ALBI Grade 3 Is Associated with Increased Mortality After Liver Transplantation
This study aimed to evaluate ALBI score as a prognostic factor in LT.MethodsThis  is a single-center analysis of patients undergoing LT between October 2001 and June 2017. Primary endpoint was overall post-LT mortality. Secondary endpoint was 90-day mortality.ResultsOf all 301 patients included in this study, 185 (61.5%) were males. The  median age was 54.1 ± 11.3 years. Univariate and multivariate analysis revealed that ALBI grade 3 (HR 1.836, 95% CI 1.154–2.921,p  =  0.010), low serum albumin (HR 0.628, 95% CI 0.441–0.893,p  =  0.010), black race...
Source: Digestive Diseases and Sciences - January 14, 2019 Category: Gastroenterology Source Type: research

Treatment of Fatigue in Primary Biliary Cholangitis: A Systematic Review and Meta-Analysis
ConclusionsWhile there is some improvement in fatigue with liver transplantation, there is a lack of high-quality evidence supporting the efficacy of any other intervention in the treatment of PBC-related fatigue. Further research into the underlying pathophysiology may help guide future trials. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 10, 2019 Category: Gastroenterology Source Type: research

Measuring Barrett ’s Epithelial Thickness with Volumetric Laser Endomicroscopy as a Biomarker to Guide Treatment
ConclusionWe developed an algorithm that improves VLE visualization of the mucosal layers of the esophageal wall and enables rapid and reliable measurement of BET. Interobserver variability measurements were significantly reduced when using contrast enhancement. Studies are underway to correlate BET with treatment response. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 10, 2019 Category: Gastroenterology Source Type: research

Risk of Clostridium difficile Infection with Systemic Antimicrobial Therapy Following Successful Fecal Microbiota Transplant: Should We Recommend Anti- Clostridium difficile Antibiotic Prophylaxis?
AbstractIntroductionThe risk of a newClostridium difficile infection (CDI) after FMT is unknown if non-CDI antibiotics are required. It is uncertain if anti-CDI prophylaxis or probiotics would reduce risk. We therefore aimed to compare the risk of CDI with and without antibiotic exposure and the benefit of concomitant anti-CDI antibiotic or probiotic prophylaxis.MethodsThis is a multicenter retrospective study carried out at three large FMT referral centers of patients who underwent FMT for recurrent CDI. Patients were assessed for antibiotic use, as well as concomitant use of prophylactic anti-CDI antibiotics or probiotic...
Source: Digestive Diseases and Sciences - January 10, 2019 Category: Gastroenterology Source Type: research

Predictive Value of Anastomotic Blood Supply for Anastomotic Stricture After Esophagectomy in Esophageal Cancer
AbstractBackgroundInsufficient blood supply in the gastric tube is considered as a risk factor for postoperative anastomotic strictures in patients receiving esophagectomy, but the direct evidence is lacking.AimsWe aimed to investigate the correlation between perioperative blood supply in the anastomotic area of the gastric tube and the formation of anastomotic strictures in the patients undergoing esophagectomy.MethodsThis prospective study included 60 patients with esophageal squamous cell carcinoma undergoing Ivor Lewis  esophagectomy between March 2014 and February 2016, which were divided into stricture group (n&...
Source: Digestive Diseases and Sciences - January 10, 2019 Category: Gastroenterology Source Type: research

Hepatic miR-181b-5p Contributes to Glycogen Synthesis Through Targeting EGR1
ConclusionWe demonstrated that miR-181b-5p contributes to glycogen synthesis by targeting EGR1, thereby regulating PTEN expression to mediate hepatic insulin resistance. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 9, 2019 Category: Gastroenterology Source Type: research

Sessile Serrated Polyps with Synchronous Conventional Adenomas Increase Risk of Future Advanced Neoplasia
ConclusionsSynchronous adenoma increases the risk of advanced neoplasia for SSP equivalent to that seen following high-risk adenoma. Guidelines for surveillance should take into account concurrent pathologies with SSP. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 9, 2019 Category: Gastroenterology Source Type: research

Open-and-Shut Case: An Uncommon Cause of GI Bleeding
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 9, 2019 Category: Gastroenterology Source Type: research

Older Age and Disease Duration Are Highly Associated with Hepatocellular Carcinoma in Patients with Autoimmune Hepatitis
ConclusionsAIH is a rare cause (1.6%) for HCC in Midwestern USA with a decreasing trend over 14.5  years. Ten percent of AIH-HCC patients did not have cirrhosis at time of HCC diagnosis. Patients with prolonged duration of the disease and older age are at high risk to develop HCC. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 7, 2019 Category: Gastroenterology Source Type: research

4-Phenylbutyric Acid Attenuates Endoplasmic Reticulum Stress-Mediated Intestinal Epithelial Cell Apoptosis in Rats with Severe Acute Pancreatitis
ConclusionsERS may be considered a predominant pathway, which is involved in the apoptosis of IECs during SAP. Furthermore, 4-PBA protects IECs against apoptosis in STC-induced SAP by attenuating the severity of ERS. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 4, 2019 Category: Gastroenterology Source Type: research

Earlier Anti-Tumor Necrosis Factor Therapy of Crohn ’s Disease Correlates with Slower Progression of Bowel Damage
ConclusionsEarlier introduction of biologics tended to correlate with the slower progression of bowel damage in CD, reflected by the reduced rate of L émann index progression. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 3, 2019 Category: Gastroenterology Source Type: research

Scope of Burnout Among Young Gastroenterologists and Practical Solutions from Gastroenterology and Other Disciplines
AbstractBurnout is a critical issue among physicians, including gastroenterologists. Up to 50% of gastroenterologists have reported symptoms of burnout in national assessments, leading to increased recognition of the burden of burnout among subspecialty societies. Particularly alarming in these assessments of burnout is the suggestion of increased rates of burnout among trainees and early career gastroenterologists. In this article, we describe the scope of burnout among young gastroenterologists and the risk factors that contribute. In addition, we will offer practical solutions to reduce burnout based on insights develop...
Source: Digestive Diseases and Sciences - January 3, 2019 Category: Gastroenterology Source Type: research

Seeing Double: An Unusual Case of Chronic Recurrent Nausea, Vomiting and Epigastric Pain
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 3, 2019 Category: Gastroenterology Source Type: research

Ruptured Oncocytic Intraductal Papillary Neoplasm: Think Beyond the Pancreas
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 3, 2019 Category: Gastroenterology Source Type: research

Serum Procalcitonin as a Potential Early Predictor of Short-Term Outcomes in Acute Severe Ulcerative Colitis
AbstractBackgroundDelayed colectomy can be life-threatening for patients with acute severe ulcerative colitis (ASUC). However, few biomarkers can predict the outcomes of ASUC patients before treatment. Serum procalcitonin (PCT) has been observed to be increased in ASUC patients.AimThe aim of this study was to estimate the association between serum PCT and short-term outcomes in patients with ASUC.MethodsA single-center observational study was conducted at a referral hospital from January 2012 to January 2018. Hospitalized ASUC patients, who were administered intravenous corticosteroids (IVCS), were enrolled and followed up...
Source: Digestive Diseases and Sciences - January 2, 2019 Category: Gastroenterology Source Type: research

Epigenetic Alternations of MicroRNAs and DNA Methylation Contribute to Liver Metastasis of Colorectal Cancer
ConclusionOur study identified a series of differentially expressed genes which are associated with epigenetic alternations of miRNAs and DNA methylation in colorectal liver metastasis. Up-regulated genes of SLC10A1, MAPT, SHANK2, PTH1R, and C2, as well as down-regulated genes of CAB39, CFLAR, CTSC, THBS1, and TRAPPC3 were associated with both miRNA and DNA methylation, which might become promising biomarker of colorectal liver metastasis in future. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 2, 2019 Category: Gastroenterology Source Type: research

Intravenous Contrast-Enhanced Ultrasound for Assessing and Grading Postoperative Recurrence of Crohn ’s Disease
ConclusionsUS shows high sensitivity and specificity for the diagnosis of postsurgical recurrence. When combined with CEUS, it can improve the detection of severe recurrence. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 2, 2019 Category: Gastroenterology Source Type: research

Concise Commentary: The Clot Thickens —Why Pylephlebitis Is One of the Most Feared Complications of Intra-abdominal Sepsis
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 2, 2019 Category: Gastroenterology Source Type: research

Withdrawal of Azathioprine in Inflammatory Bowel Disease Patients Who Sustain Remission: New Risk Factors for Relapse
ConclusionsAlmost half of the patients in whom AZA was withdrawn were in remission at 5  years. The candidates for withdrawal could be better identified based on corticosteroid dependence, previous surgery, timing of initiation, and indication for AZA. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 2, 2019 Category: Gastroenterology Source Type: research

Effect of TELEmedicine for Inflammatory Bowel Disease on Patient Activation and Self-Efficacy
ConclusionsUse of remote monitoring did not improve self-efficacy or patient activation compared to routine care. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 2, 2019 Category: Gastroenterology Source Type: research

Predictors of Biliary Strictures After Liver Transplantation Among Recipients of DCD (Donation After Cardiac Death) Grafts
ConclusionBiliary strictures occur frequently in DCD LT recipients and may be associated with older age of donor. Hyperbilirubinemia immediately after transplant and higher INR in the first 7  days after transplant may predict subsequent development of biliary strictures. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 2, 2019 Category: Gastroenterology Source Type: research

Mortality Risk of Inflammatory Bowel Disease: A Case –Control Study of New York State Death Records
ConclusionsBoth CD and UC cases were more likely to die of a gastrointestinal etiology, and CD patients were more likely to die prematurely. There was no significant difference in the premature death, average age of death, and cause of death in this IBD population after the availability of anti-TNF therapy. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 2, 2019 Category: Gastroenterology Source Type: research

Effect of Pancreatic Mass Size on Clinical Outcomes of Endoscopic Ultrasound-Guided Fine-Needle Aspiration
AbstractBackgroundEndoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) has high diagnostic accuracy for pancreatic diseases. However, the effect of mass size on diagnostic accuracy has yet to be determined, especially for small pancreatic lesions. We aimed to determine the effect of pancreatic mass size on the diagnostic yield of EUS-FNA.MethodsWe searched the database in Hokkaido University Hospital between May 2008 and December 2016 and identified solid pancreatic lesions examined by EUS-FNA. All lesions were stratified into five groups based on mass sizes: groups A (
Source: Digestive Diseases and Sciences - January 2, 2019 Category: Gastroenterology Source Type: research

Concise Commentary: Bloating Makes a Comeback in IBS
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 2, 2019 Category: Gastroenterology Source Type: research

Active β-Catenin Signaling in the Small Intestine of Humans During Infancy
AbstractBackgroundWnt- β-catenin signaling is essential for homeostasis of intestinal stem cells in mice and is thought to promote intestinal crypt fission.AimsThe aim of this study was to investigate Wnt- β-catenin signaling in intestinal crypts of human infants.MethodsDuodenal biopsies from nine infants (mean, range 0.9  years, 0.3–2 years) and 11 adults (mean, range 43 years, 34–71 years) were collected endoscopically. Active β-catenin signaling was assessed by cytoplasmic and nuclear β-catenin, nuclear c-Myc, and cytoplasmic Axin-2 expression in the base of crypts. Ti...
Source: Digestive Diseases and Sciences - January 1, 2019 Category: Gastroenterology Source Type: research

Preventive Effects of Epinephrine for Critically Ill Patients? More Questions Waiting to Be Answered
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 1, 2019 Category: Gastroenterology Source Type: research

Correction to: A Novel Rabbit Model for Benign Biliary Stricture Formation and the Effects of Medication Infusions on Stricture Formation
The original version of the article unfortunately contained an error in funding information. This has been corrected with this erratum. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 1, 2019 Category: Gastroenterology Source Type: research

Villus Growth, Increased Intestinal Epithelial Sodium Selectivity, and Hyperaldosteronism Are Mechanisms of Adaptation in a Murine Model of Short Bowel Syndrome
Conclusions40% ICR results in moderate to severe short bowel syndrome. Successful adaptation to the short bowel situation involves villus elongation but does not correlate with the degree of villus elongation alone. In addition, increased intestinal epithelial sodium permeability facilitates sodium-coupled solute transport. Hyperaldosteronism correlates with the severity of weight loss, indicates volume depletion, and counterregulates water loss. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - December 20, 2018 Category: Gastroenterology Source Type: research

Clinical Insights into Superior Mesenteric Artery Syndrome with Multiple Diseases: A Case Report
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - December 20, 2018 Category: Gastroenterology Source Type: research

Duodenoscope-Associated Infections: Update on an Emerging Problem
AbstractThe duodenoscope is among the most complex medical instruments that undergo disinfection between patients. Transmission of infection by contaminated scopes has remained a challenge since its inception. Notable risk factors for pathogen transmission include non-adherence to disinfection guidelines, encouragement of biofilm deposition due to complex design and surface defects and contaminated automated endoscope reprocessors. The most common infections following endoscopy are endogenous infections involving the patient ’s own gut flora. Exogenous infections, on the other hand, are associated with contaminated s...
Source: Digestive Diseases and Sciences - December 19, 2018 Category: Gastroenterology Source Type: research

Obesity Is Associated with Increased Risk of Colectomy in Inflammatory Bowel Disease Patients Hospitalized with Clostridium difficile Infection
AbstractBackgroundObesity and inflammatory bowel disease (IBD) are associated with increased risk ofClostridium difficile infection (CDI). The effect of obesity on IBD course and development of complications is poorly understood. We performed this study to examine the effect of obesity on CDI-related morbidity and mortality in hospitalized patients with IBD.MethodsWe used data from the National Inpatient Sample across five study years (2010 –2014) to identify patients ≥ 18 years hospitalized with both CDI and IBD. We compared the outcomes of in-hospital mortality, partial or total colectomy, hospital l...
Source: Digestive Diseases and Sciences - December 19, 2018 Category: Gastroenterology Source Type: research

Introduction to the IBD Case Conference Series
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - December 18, 2018 Category: Gastroenterology Source Type: research

Bloating in Irritable Bowel Syndrome Is Associated with Symptoms Severity, Psychological Factors, and Comorbidities
ConclusionsAbdominal bloating in IBS is associated with increased symptoms and pain severity, somatization, depression, fibromyalgia, and altered dietary fluids composition. Recognizing and addressing these factors in the diagnosis and management of patients with IBS may improve clinical outcome. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - December 18, 2018 Category: Gastroenterology Source Type: research

Higher Mucosal Healing with Tumor Necrosis Factor Inhibitors in Combination with Thiopurines Compared to Methotrexate in Crohn ’s Disease
AbstractBackgroundThe differential impact of anti-tumor necrosis factor (anti-TNF) therapy with methotrexate versus thiopurine co-therapy on endoscopic remission remains uncertain.AimsTo compare rates of endoscopic remission based on methotrexate or thiopurine co-therapy used with anti-TNF therapy in Crohn ’s disease.MethodsA retrospective observational study at two tertiary centers between 2010 and 2016 compared endoscopic remission rates and persistence on anti-TNF therapy in combination with methotrexate versus thiopurines for at least 3  months.ResultsOf 412 patients on anti-TNF therapy, 278 (67%) received i...
Source: Digestive Diseases and Sciences - December 17, 2018 Category: Gastroenterology Source Type: research

Use of Hepatitis C-Positive Liver Grafts in Hepatitis C-Negative Recipients
AbstractAs the demand for liver transplantation continues to rise, the scarcity of liver donor grafts has led to the use of extended criteria grafts for liver transplantation in select group of patients. Hepatitis C-seropositive liver grafts have been used primarily in hepatitis C-positive recipients, with studies showing non-inferior outcomes when compared to hepatitis C-negative grafts. Studies suggest that hepatitis C serology status of the donor liver does not influence the patient or graft outcomes in the recipient. These results advocate for offering hepatitis C-positive grafts to all patients awaiting liver transpla...
Source: Digestive Diseases and Sciences - December 17, 2018 Category: Gastroenterology Source Type: research

Branched Short-Chain Fatty Acid Isovaleric Acid Causes Colonic Smooth Muscle Relaxation via cAMP/PKA Pathway
ConclusionsThe branched-chain fatty acid IVA acts directly on colonic smooth muscle and causes muscle relaxation via the PKA pathway. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - December 17, 2018 Category: Gastroenterology Source Type: research

Mechanisms of Probiotic VSL#3 in a Rat Model of Visceral Hypersensitivity Involves the Mast Cell-PAR2-TRPV1 Pathway
ConclusionsThe probiotic VSL#3 decreases VH in rat model of VH. The mechanism may be related with the mast cell-PAR2-TRPV1 signaling pathway. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - December 17, 2018 Category: Gastroenterology Source Type: research

Gut Microbiome, Short-Chain Fatty Acids, and Mucosa Injury in Young Adults with Human Immunodeficiency Virus Infection
ConclusionThe differences in the distribution of intestinal flora between HIV-infected and healthy individuals, especially some SCFAs, suggest that there is already a predisposition to intestinal mucosa damage in HIV-infected individuals. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - December 17, 2018 Category: Gastroenterology Source Type: research

Predictors of Re-bleeding and Mortality Among Patients with Refractory Variceal Bleeding Undergoing Salvage Transjugular Intrahepatic Portosystemic Shunt (TIPS)
ConclusionsIn this large cohort of patients undergoing salvage TIPS, MELD and Child –Pugh scores were predictive of short- and long-term mortality, respectively. Pre-TIPS intensive care unit stay was independently associated with TIPS failure and mortality at 6 weeks and 12 months. Salvage TIPS is futile in patients with Child–Pugh score of 14–15. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - December 17, 2018 Category: Gastroenterology Source Type: research

Repetitive Position Change Improves Gastric Cleanliness for Magnetically Controlled Capsule Gastroscopy
This study aims to determine if repetitive position change after dimethicone premedication could further improve gastric cleanliness for MCCG.MethodsConsecutive patients referred for MCCG in our center from May 7 to May 31, 2018 were prospectively enrolled and randomized to undergo repetitive position change for 15  min (position change group) or not (conventional group) after ingesting dimethicone. Primary outcome was gastric cleanliness score and secondary outcomes were detection rate of positive findings, number of lesions per patient, gastric examination time, and safety of MCCG.ResultsTotals of 43 and 40 were inc...
Source: Digestive Diseases and Sciences - December 17, 2018 Category: Gastroenterology Source Type: research

Management of Non-tumoral Portal Vein Thrombosis in Patients with Cirrhosis
AbstractNon-tumoral portal vein thrombosis (PVT) remains a highly relevant topic in the field of hepatology and liver transplantation with much surrounding controversy. Although multiple studies have shown that PVT is associated with adverse outcomes with increased morbidity and mortality rates, others have not reported the same clinical impact of PVT, arguing rather that incident PVT reflects worsening portal hypertension and the natural history of the disease. Despite this uncertainly, PVT is a dilemma facing the clinician on a daily basis often requiring a multidisciplinary team-based approach between hepatologists, tra...
Source: Digestive Diseases and Sciences - December 17, 2018 Category: Gastroenterology Source Type: research

miR-214 Down-Regulation Promoted Hypoxia/Reoxygenation-Induced Hepatocyte Apoptosis Through TRAF1/ASK1/JNK Pathway
ConclusionmiR-214 overexpression reduces hepatocyte apoptosis after HIR injury through negatively regulating TRAF1/ASK1/JNK pathway. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - December 17, 2018 Category: Gastroenterology Source Type: research

EphA3 Downregulation by Hypermethylation Associated with Lymph Node Metastasis and TNM Stage in Colorectal Cancer
AbstractBackgroundEphA3 is a member of Eph receptors, which is involved in tumorigenesis. The expression and clinical significance of EphA3 in colorectal cancer (CRC) have not been fully investigated.MethodsFour colon cancer cell lines and a set of CRC tissues were examined for EphA3 expression. The methylation status of a CpG island within the EphA3 promoter, the presence of four somaticEPHA3 mutations, andEPHA3 gene copy number variations were also analyzed in colon cancer cell lines.ResultsEphA3 expression was lost in all colon cancer cell lines examined. EphA3 expression was lower in tumor tissues when compared with no...
Source: Digestive Diseases and Sciences - December 17, 2018 Category: Gastroenterology Source Type: research

Inhibition of I κB Kinase 2 Attenuated the Proliferation and Induced Apoptosis of Gastric Cancer
ConclusionOur results indicate that IKK2 promotes the GC cell proliferation and inhibits their apoptosis, suggesting it may be a potential target for GC therapy. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - December 17, 2018 Category: Gastroenterology Source Type: research

Coming Complications of Nonalcoholic Fatty Liver Disease: Time to GNASH Your Teeth
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - December 17, 2018 Category: Gastroenterology Source Type: research

Incidence of Recurrent NASH-Related Allograft Cirrhosis
ConclusionAlthough recurrent NASH following LT is common, the development of allograft cirrhosis is rare. These findings are useful when counseling patients and important to consider during their post-LT care. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - December 17, 2018 Category: Gastroenterology Source Type: research

Expression and Localization of Huntingtin-Associated Protein 1 (HAP1) in the Human Digestive System
ConclusionsThis is the first study showing the differential expression and location of HAP1 in the human digestive system. These findings suggested that HAP1 may have cell-type-dependent function in the gastrointestinal tract and may serve as a diagnostic marker for pancreatic cancer. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - December 17, 2018 Category: Gastroenterology Source Type: research