Polyphosphate, Derived from Lactobacillus brevis, Modulates the Intestinal Microbiome and Attenuates Acute Pancreatitis
ConclusionsPoly P attenuates AP through both modification of the intestinal microbiome and enhancement of the intestinal barrier integrity. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Circ-LDLRAD3 Enhances Cell Growth, Migration, and Invasion and Inhibits Apoptosis by Regulating MiR-224-5p/NRP2 Axis in Gastric Cancer
ConclusionsCirc-LDLRAD3 facilitates GC progression by regulating miR-224-5p/NRP2 axis, providing new insights for the researches of GC treatment. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

History of Cholecystectomy and Risk of Clostridium Difficile Infection
ConclusionsCholecystectomy is associated with mild increased risk of incident CDI, but this effect is not influenced by use of proton pump inhibitors, antibiotics, or hospitalization. Future prospective studies should be conducted to validate these findings and evaluate bile acid changes after a cholecystectomy. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Predictors of Abnormal Functional Luminal Impedance Planimetry Findings in Non-mechanical Esophagogastric Junction Outflow Obstruction
ConclusionsIn patients with non-mechanical EGJOO, reflux burden scores and FLIP diameters can aid in predicting DI. These results may provide useful adjunctive data to help in differentiating which patients have meaningful outflow obstruction. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

DEAD-Box Helicase 3 X-Linked Promotes Metastasis by Inducing Epithelial-Mesenchymal Transition via p62/Sequestosome-1
ConclusionsOur results demonstrated that DDX3X activates NF- κB and promotes metastasis by inducing EMT via p62. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

A Microsimulation Model to Project the 5-Year Impact of Using Hyperbaric Oxygen Therapy for Ulcerative Colitis Patients Hospitalized for Acute Flares
AbstractBackgroundHyperbaric oxygen therapy (HBOT) improves short-term outcomes for ulcerative colitis (UC) patients hospitalized for acute flares. Longer-term impacts and cost-effectiveness are unknown.MethodsWe compared disease outcomes and cost-effectiveness of HBOT in addition to standard of  care versus standard of care alone for UC patients hospitalized for acute flares using a microsimulation model. Published literature was used for transition probabilities, costs, and quality-adjusted life year (QALY) estimates. We modeled 100,000 individuals in each group over a 5-year horizon an d compared rates of re-h...
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Does Famotidine Reduce the Risk of Progression to Severe Disease, Death, and Intubation for COVID-19 Patients? A Systemic Review and Meta-Analysis
ConclusionFamotidine has no significant protective effect in reducing the risk of developing serious illness, death, and intubation for COVID-19 patients. More original studies are needed to further clarify whether it is associated with reduced risk of the severity, death, and intubation for COVID-19 patients. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Efficacy of Pregabalin and Antioxidants Combination in Reducing Pain in Chronic Pancreatitis: A Double Blind Randomized Trial
ConclusionThe combination of pregabalin and antioxidant significantly reduces the pain, requirement of non-opioid analgesics, and the number of hospital admissions in patients with CP. It also significantly improves the overall patient satisfaction.Clinical Trials Register NumberCTRI/2017/05/008492. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Anticoagulant Reversal in Gastrointestinal Bleeding: Review of Treatment Guidelines
ConclusionsThe utility of anticoagulant reversal agents in GI bleeding is recognized in guidelines; however, such agents should be reserved for use in truly life-threatening scenarios. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Personalized Best: Toward Improving Care in Ulcerative Colitis
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Back to the Source: Molecular Identification of Methanogenic Archaea as Markers of Colonic Methane Production
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Special FX: Harnessing the Farnesoid-X-Receptor to Control Bile Acid Synthesis
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Paying Attention to Miss(ed) FITs
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Probiotic-Derived Polyphosphate Prevents Pancreatitis
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Annoyed with Haemorrhoids? Risks of the Emborrhoid Technique
We describe a patient who developed recto-sigmoidal ischaemia after embolization of the haemorrhoidal arteries, known as the “emborrhoid” technique, with persistence of rectal bleeding and progressive rectal stenosis. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

More Than Just Heartburn: Does Famotidine Effectively Treat Patients with COVID-19?
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Cec and You Shall Find: Cecal Perforation in a Patient with COVID-19
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Author Spotlight: Lisa Fralleone
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Author Spotlight: Ioana Baiu
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Polyphosphate, Derived from Lactobacillus brevis, Modulates the Intestinal Microbiome and Attenuates Acute Pancreatitis
ConclusionsPoly P attenuates AP through both modification of the intestinal microbiome and enhancement of the intestinal barrier integrity. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

History of Cholecystectomy and Risk of Clostridium Difficile Infection
ConclusionsCholecystectomy is associated with mild increased risk of incident CDI, but this effect is not influenced by use of proton pump inhibitors, antibiotics, or hospitalization. Future prospective studies should be conducted to validate these findings and evaluate bile acid changes after a cholecystectomy. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Predictors of Abnormal Functional Luminal Impedance Planimetry Findings in Non-mechanical Esophagogastric Junction Outflow Obstruction
ConclusionsIn patients with non-mechanical EGJOO, reflux burden scores and FLIP diameters can aid in predicting DI. These results may provide useful adjunctive data to help in differentiating which patients have meaningful outflow obstruction. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

A Microsimulation Model to Project the 5-Year Impact of Using Hyperbaric Oxygen Therapy for Ulcerative Colitis Patients Hospitalized for Acute Flares
AbstractBackgroundHyperbaric oxygen therapy (HBOT) improves short-term outcomes for ulcerative colitis (UC) patients hospitalized for acute flares. Longer-term impacts and cost-effectiveness are unknown.MethodsWe compared disease outcomes and cost-effectiveness of HBOT in addition to standard of  care versus standard of care alone for UC patients hospitalized for acute flares using a microsimulation model. Published literature was used for transition probabilities, costs, and quality-adjusted life year (QALY) estimates. We modeled 100,000 individuals in each group over a 5-year horizon an d compared rates of re-h...
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Efficacy of Pregabalin and Antioxidants Combination in Reducing Pain in Chronic Pancreatitis: A Double Blind Randomized Trial
ConclusionThe combination of pregabalin and antioxidant significantly reduces the pain, requirement of non-opioid analgesics, and the number of hospital admissions in patients with CP. It also significantly improves the overall patient satisfaction.Clinical Trials Register NumberCTRI/2017/05/008492. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Personalized Best: Toward Improving Care in Ulcerative Colitis
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Author Spotlight: Lisa Fralleone
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 13, 2021 Category: Gastroenterology Source Type: research

Lactate Ringer ’s Versus Normal Saline in the Management of Acute Pancreatitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
ConclusionNo differences were found in the mortality and SIRS at 24, 48, and 72  h in patients treated with LR and NS. In contrast, patients who received LR had a lower risk of ICU admission and lower hospital stay than NS. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 11, 2021 Category: Gastroenterology Source Type: research

Urban –Rural Differences in Health Care Utilization for Inflammatory Bowel Disease in the USA, 2017
AbstractBackgroundUrban –rural differences in IBD-specific health care utilization at the national level have not been examined in the USA.AimsWe compared urban and rural rates of IBD-related office visits and IBD-specific (Crohn ’s disease (CD) or ulcerative colitis (UC)) hospitalizations and emergency department (ED) visits.MethodsFrom multiple national data sources, we compared national rates using Z test and compared estimates of patient and hospital characteristics and hospitalization outcomes between urban and rural areas using Chi-square and t tests.ResultsIn 2015 and 2016, digestive disease-related offi...
Source: Digestive Diseases and Sciences - October 11, 2021 Category: Gastroenterology Source Type: research

Clinical Significance of Acylphosphatase 1 Expression in Combined HCC-iCCA, HCC, and iCCA
ConclusionHigh ACYP1 expression could influence the prognosis of cHCC-iCCA, HCC, and iCCA patients. In vitro ACYP1 expression influences the tumor growth and cell viability in both HCC and iCCA by regulating anti-apoptosis proteins. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 9, 2021 Category: Gastroenterology Source Type: research

A Transient Treatable Tumor of the Pancreas
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 8, 2021 Category: Gastroenterology Source Type: research

Meta-Analysis of the Composition of Human Intestinal Gases
DiscussionThe meta-analysis has found defined concentrations of the five most common gases present in human colonic gas. Limitations included heterogenic methodologies, a low number of participants, and few recent studies. These findings may be helpful in diagnostic applications where colonic gas volume and composition are crucial factors, including functional disorders, microbiome analyses, and bowel perforation diagnostics. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 8, 2021 Category: Gastroenterology Source Type: research

Silencing GS Homeobox 2 Alleviates Gemcitabine Resistance in Pancreatic Cancer Cells by Activating SHH/GLI1 Signaling Pathway
This study evaluates the role of GSH2 in the development and drug resistance of pancreatic cancer. Both cell culture and xenograft mouse model were used. Immunohistochemistry, Western blotting and quantitative RT-PCR were used to examine the expression of GSH2 and other related molecules. CCK8 assay was used to test the cell proliferation, and flow cytometry used to examine cell apoptosis upon gemcitabine treatment. It was found that GSH2 is overexpressed in human pancreatic cancer tissues and cells. The expression of SHH and GLI1 was reversely correlated with GSH2 in pancreatic cancer cells. SHH and GLI1 have protein &nda...
Source: Digestive Diseases and Sciences - October 8, 2021 Category: Gastroenterology Source Type: research

Transitioning from the Mountains to the Mecca: One Gastroenterologist ’s Journey
AbstractOver the course of their careers, gastroenterologists not infrequently move from one practice setting to another. Perhaps the most uncommon path is for a gastroenterologist well established in private practice to transition to a high-powered academic setting in late career. Below is a description of the career path that I chose, written in part to provide career and personal guidance to the next generation of gastroenterologists. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 8, 2021 Category: Gastroenterology Source Type: research

Creating a Pathway to Leadership for Women in Gastroenterology
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 8, 2021 Category: Gastroenterology Source Type: research

A Transient Treatable Tumor of the Pancreas
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 8, 2021 Category: Gastroenterology Source Type: research

Meta-Analysis of the Composition of Human Intestinal Gases
DiscussionThe meta-analysis has found defined concentrations of the five most common gases present in human colonic gas. Limitations included heterogenic methodologies, a low number of participants, and few recent studies. These findings may be helpful in diagnostic applications where colonic gas volume and composition are crucial factors, including functional disorders, microbiome analyses, and bowel perforation diagnostics. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 8, 2021 Category: Gastroenterology Source Type: research

Silencing GS Homeobox 2 Alleviates Gemcitabine Resistance in Pancreatic Cancer Cells by Activating SHH/GLI1 Signaling Pathway
This study evaluates the role of GSH2 in the development and drug resistance of pancreatic cancer. Both cell culture and xenograft mouse model were used. Immunohistochemistry, Western blotting and quantitative RT-PCR were used to examine the expression of GSH2 and other related molecules. CCK8 assay was used to test the cell proliferation, and flow cytometry used to examine cell apoptosis upon gemcitabine treatment. It was found that GSH2 is overexpressed in human pancreatic cancer tissues and cells. The expression of SHH and GLI1 was reversely correlated with GSH2 in pancreatic cancer cells. SHH and GLI1 have protein &nda...
Source: Digestive Diseases and Sciences - October 8, 2021 Category: Gastroenterology Source Type: research

Transitioning from the Mountains to the Mecca: One Gastroenterologist ’s Journey
AbstractOver the course of their careers, gastroenterologists not infrequently move from one practice setting to another. Perhaps the most uncommon path is for a gastroenterologist well established in private practice to transition to a high-powered academic setting in late career. Below is a description of the career path that I chose, written in part to provide career and personal guidance to the next generation of gastroenterologists. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 8, 2021 Category: Gastroenterology Source Type: research

Creating a Pathway to Leadership for Women in Gastroenterology
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 8, 2021 Category: Gastroenterology Source Type: research

Positive Association Between Sleep Disturbance and Prevalence of Functional Dyspepsia in Japanese Young People
ConclusionsSleep disturbance may be independently positively associated with the prevalence of FD among Japanese young people. Nocturnal awakening and daytime sleepiness were not associated with EPS; the other types of sleep disturbance were independently positively associated with EPS and PDS. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 7, 2021 Category: Gastroenterology Source Type: research

De Novo Ostomy Placement Is Associated with Increased Outpatient Opioid Use In Patients with Inflammatory Bowel Disease
ConclusionsA multimodal approach to pain management for IBD patients, as well as increased recognition that any patient with a de novo ostomy is at particular risk of opioid use, is needed. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - October 6, 2021 Category: Gastroenterology Source Type: research

Heparin-Binding Protein Levels at Admission and Within 24  h Are Associated with Persistent Organ Failure in Acute Pancreatitis
AbstractBackgroundIdentification of patients at risk for persistent organ failure (POF) early in the course of acute pancreatitis (AP) is critical for early intervention. Heparin-binding protein (HBP) levels are closely related to inflammation. Therefore, we investigated the relationship between HBP levels and POF in patients with AP.MethodsThis observational cohort study analyzed 66 patients with AP and 14 healthy volunteers between June 2019 and December 2019. Baseline characteristics, laboratory data, and severity scores of patients with different degrees of AP were compared. Levels of HBP were measured by ELISA. Serum ...
Source: Digestive Diseases and Sciences - September 19, 2021 Category: Gastroenterology Source Type: research

Evolving Role of Thiopurines in Inflammatory Bowel Disease in the Era of Biologics and New Small Molecules
AbstractIn recent years, with the increasing availability of biologic therapies and due to safety concerns, the role of thiopurines in the management of inflammatory bowel disease has been questioned. While acknowledging that the benefit/risk ratio of biologic therapies is very high, they are expensive and are not required by a majority of patients. Therefore, thiopurines do retain an important role as steroid-sparing and maintenance agents when used as monotherapy, and in combination therapy with biologics due to their clinical and pharmacokinetic optimization of anti-tumor necrosis factor agents in particular. Safety con...
Source: Digestive Diseases and Sciences - September 19, 2021 Category: Gastroenterology Source Type: research

Long Non-coding RNA LINC01503 Promotes Gastric Cardia Adenocarcinoma Progression via miR-133a-5p/VIM Axis and EMT Process
ConclusionLINC01503 serves as an oncogenic lncRNA to promote GCA progression via affecting LINC01503/miR-133a-5p/VIM axis and EMT process. LINC01503 not only has a critical role in GCA progression but also provide a novel potential biomarker in predicting prognosis for GCA patients. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - September 19, 2021 Category: Gastroenterology Source Type: research

Outcomes in Severe Upper GI Hemorrhage from Dieulafoy ’s Lesion with Monitoring of Arterial Blood Flow
AbstractBackgroundDieulafoy ’s lesion (DL) is a rare but increasingly recognized cause of severe upper GI hemorrhage (SUGIH). There is little consensus regarding the endoscopic approach to management of bleeding from DL.AimsOur purposes were to compare 30-day outcomes of patients with SUGIH from DL with Doppler endoscopic probe (DEP) monitoring of blood flow and guided treatment versus standard visually guided hemostasis (VG).MethodsEighty-two consecutive DL patients with SUGIH were identified in a large CURE Hemostasis database from previous prospective cohort studies and two recent RCTs at two university-based medi...
Source: Digestive Diseases and Sciences - September 19, 2021 Category: Gastroenterology Source Type: research

Impact of COVID-19 Pandemic on Training: Global Perceptions of Gastroenterology and Hepatology Fellows in the USA
ConclusionsOur results show that the COVID-19 pandemic has impacted GI fellowship training in the USA in multiple domains, including gastrointestinal endoscopy, inpatient consults, outpatient clinics, and educational conferences. Our study highlights the importance of considering and incorporating fellows ’ viewpoints, as changes are made in response to the ongoing pandemic. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - September 19, 2021 Category: Gastroenterology Source Type: research

Phenolic Compounds Promote Diversity of Gut Microbiota and Maintain Colonic Health
AbstractThe role of non-energy-yielding nutrients on health has been meticulously studied, and the evidence shows that a compound can exert significant effects on health even if not strictly required by the organism. Phenolic compounds are among the most widely studied molecules that fit this description; they are found in plants as secondary metabolites and are not required by humans for growth or development, but they can influence a wide array of processes that modulate health across multiple organs and systems. The lower gastrointestinal tract is a prime site of action of phenolic compounds, namely, by their effects on...
Source: Digestive Diseases and Sciences - September 19, 2021 Category: Gastroenterology Source Type: research

Gastric Antral Vascular Ectasia and Vitamin D Deficiency: New Associated Disease and Proposed Pathogenetic Mechanisms
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - September 19, 2021 Category: Gastroenterology Source Type: research