Predictive Factors of Mild and Severe Fibrosis in Colorectal Endoscopic Submucosal Dissection
ConclusionsWe identified the predictive factors of mild and severe fibrosis. It is preferable that a more experienced physician performs ESD for the lesions with F2 fibrosis. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - July 16, 2019 Category: Gastroenterology Source Type: research

Effects of Pristine C 60 Fullerenes on Liver and Pancreas in α-Naphthylisothiocyanate-Induced Cholangitis
ConclusionPristine C60 fullerene inhibits liver inflammation and fibrogenesis and partially improved liver and pancreas state under acute and chronic cholangitis. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - July 16, 2019 Category: Gastroenterology Source Type: research

Liver Transplantation for Nonalcoholic Steatohepatitis: Pathophysiology of Recurrence and Clinical Challenges
AbstractNonalcoholic steatohepatitis is the fastest-growing indication for the liver transplant and a leading cause of hepatocellular carcinoma among patients listed for liver transplantation in the USA. Post-transplant nonalcoholic hepatic steatosis and steatohepatitis are frequent complications of liver transplantation. Nonalcoholic steatohepatitis poses a significant challenge in both pre- and post-transplant period due to its association with metabolic syndrome, coronary artery disease, chronic kidney disease, and obstructive sleep apnea. While optimal therapy is not yet available in the post-liver transplant setting, ...
Source: Digestive Diseases and Sciences - July 16, 2019 Category: Gastroenterology Source Type: research

Fecal Microbiota Transplantation in Pouchitis: Clinical, Endoscopic, Histologic, and Microbiota Results from a Pilot Study
ConclusionsA single FMT has a tolerable short-term safety profile and may be associated with a decrease in bowel movements in patients with chronic pouchitis; however, no robust endoscopic or histologic changes were observed. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - July 13, 2019 Category: Gastroenterology Source Type: research

Volume-Based Measurement Testing for Patients with Increased Rectal Volumes
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - July 13, 2019 Category: Gastroenterology Source Type: research

Caregiver Burden in Gastroparesis and GERD: Correlation with Disease Severity, Healthcare Utilization and Work Productivity
AbstractBackgroundCaregiver burden can be significant in chronic gastrointestinal diseases. No studies have been performed to evaluate caregiver burden in gastroparesis or gastroesophageal reflux disease (GERD).Aims(1) Assess the caregiver burden in gastroparesis and GERD patients and healthy volunteers (HVs); (2) correlate the caregiver burden of these patients to the severity of patients ’ symptoms, healthcare utilization, and work productivity of the patients and the caregivers.MethodsPatients with gastroparesis and GERD, seen between June 2018 and November 2018, completed Patient Assessment of Gastrointestinal Sy...
Source: Digestive Diseases and Sciences - July 12, 2019 Category: Gastroenterology Source Type: research

Epidemiology of Large Bowel Carcinoid Tumors in the USA: A Population-Based National Study
AbstractBackground and AimsPrior studies have shown that about 90% of all carcinoid tumors occur in the GI tract. However, epidemiological studies of these tumors have been limited by small sample size. Our aim was to obtain a more robust epidemiologic survey of large bowel carcinoids (LBC), using population-based data in order to more accurately identify risk factors for these tumors.MethodsWe used a commercial database (Explorys Inc, Cleveland, OH) which includes electronic health record data from 26 major integrated US healthcare systems. We identified all patients aged 18 and older who were diagnosed with LBC, excludin...
Source: Digestive Diseases and Sciences - July 12, 2019 Category: Gastroenterology Source Type: research

Retraction Note: HAX-1 Promotes the Chemoresistance, Invasion, and Tumorigenicity of Esophageal Squamous Carcinoma Cells
The Editor-in-Chief has retracted this article [1] because Figure  3c appears to have been modified and reused as Figure 3d. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - July 12, 2019 Category: Gastroenterology Source Type: research

A Cholecystokinin Receptor Antagonist Halts Nonalcoholic Steatohepatitis and Prevents Hepatocellular Carcinoma
ConclusionThese results support the novel role of CCK receptors in the pathogenesis of NASH and HCC. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - July 11, 2019 Category: Gastroenterology Source Type: research

Bedside Measures of Frailty and Cognitive Function Correlate with Sarcopenia in Patients with Cirrhosis
AbstractBackgroundFrailty and sarcopenia are associated with mortality and poor outcomes among patients with cirrhosis. Frailty is multifactorial but due in part to sarcopenia and cognitive dysfunction. Data are limited regarding the correlation of bedside frailty and cognitive function measures with sarcopenia.AimsTo evaluate the correlations between frailty measures and muscle indices from computed tomography (CT).MethodsWe prospectively enrolled 106 patients with clinically compensated cirrhosis (and no prior hepatic encephalopathy). All patients underwent CT scan and cognitive testing (via inhibitory control test, ICT)...
Source: Digestive Diseases and Sciences - July 10, 2019 Category: Gastroenterology Source Type: research

Mass Transition: From Cecal Mass to Small Bowel Ischemia
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - July 10, 2019 Category: Gastroenterology Source Type: research

Thiopurine Therapy in Patients With Inflammatory Bowel Disease: A Focus on Metabolism and Pharmacogenetics
AbstractThiopurines have been widely used for the maintenance of remission or steroid sparing in patients with inflammatory bowel disease. However, potential drug-related adverse events frequently interfere with their use. Indeed, drug withdrawals associated with adverse reactions have been reported in approximately 25% of patients. To balance the efficacy, safety, and tolerability of thiopurines, regular monitoring of biomarkers (complete blood cell count, liver function test, and metabolic profiles), steady dose escalation, and pretreatmentthiopurine S-methyltransferase (TPMT) genotype screening have been routinely recom...
Source: Digestive Diseases and Sciences - July 9, 2019 Category: Gastroenterology Source Type: research

A Prospective Study on Contrast-Enhanced Endoscopic Ultrasound for Differential Diagnosis of Pancreatic Cystic Neoplasms
ConclusionCompared with CT, MRI, and FB-EUS, CE-EUS is better at differentiating PCNs. CE-EUS is expected to be another important imaging technique for the diagnosis of PCNs. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - July 9, 2019 Category: Gastroenterology Source Type: research

Revised Marshall Score: A New Approach to Stratifying the Severity of Acute Pancreatitis
AbstractBackgroundModified Marshall Score is one of the severity scores for acute pancreatitis (AP) and is included in the Revised Atlanta Classification, but given its utilization of a set serum creatinine level (sCr), it may misclassify stable patients with chronic kidney disease (CKD) to a more severe class just due to their elevated sCr.AimsOur study aims to evaluate the role of CKD in AP and the possibility of utilizing acute kidney injury (AKI) into developing a new scoring system.MethodsWe retrospectively reviewed the electronic medical records of three hundred consecutive patients who were diagnosed with AP during ...
Source: Digestive Diseases and Sciences - July 8, 2019 Category: Gastroenterology Source Type: research

In Vitro and In Vivo Renoprotective Effects of Telbivudine in Chronic Hepatitis B Patients Receiving Nucleotide Analogue
AbstractAimRenal toxicity of adefovir disoproxil (ADV) and tenofovir disoproxil fumarate (TDF) is a significant concern in chronic hepatitis B (CHB) patients. Early observational clinical data suggested that telbivudine (LdT) might have renoprotective effects.MethodsIn this prospective study, consecutive CHB patients on combined lamivudine (LAM)  + ADV/TDF were switched to LdT + ADV/TDF at recruitment and were followed up for 24 months. Estimated glomerular filtration rate (eGFR) was calculated with the modification of diet in renal disease equation. The effects of LdT on cell viability and...
Source: Digestive Diseases and Sciences - July 6, 2019 Category: Gastroenterology Source Type: research

Use of the Electronic Health Record to Target Patients for Non-endoscopic Barrett ’s Esophagus Screening
ConclusionsEHR-based BE risk prediction tools identify BE patients with fair accuracy. While these tools may improve the efficiency of patient targeting for BE screening in the primary care setting, challenges remain to identify high-risk patients for non-invasive BE screening in clinical practice. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - July 4, 2019 Category: Gastroenterology Source Type: research

Survey of Nonalcoholic Fatty Liver Disease Knowledge, Nutrition, and Physical Activity Patterns Among the General Public in Beijing, China
AbstractBackgroundDespite high prevalence of nonalcoholic fatty liver disease in China, understanding of the disease appears to be low.AimsWe assessed the knowledge of NAFLD among the public in Beijing, China, as well as diet and physical activity patterns, which may provide information useful for NAFLD prevention and management.MethodsWe surveyed adult patients and family members in the Peking University Health Science Center (PUHSC) ultrasound clinic and office staff in Beijing, China. Participants provided demographic and medical history data. NAFLD-related knowledge and diet and physical activity were assessed.ResultsA...
Source: Digestive Diseases and Sciences - July 4, 2019 Category: Gastroenterology Source Type: research

Myosin Heavy Chain-Associated RNA Transcripts Promotes Gastric Cancer Progression Through the miR-4529-5p/ROCK2 Axis
ConclusionOur data illustrated a MHRT/miR-4529-5p/ROCK2 regulatory axis that contributes to the tumorigenesis of gastric cancer and provided potential therapeutic targets for precise gastric cancer treatment. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - July 4, 2019 Category: Gastroenterology Source Type: research

α-Hederin Induces Apoptosis of Esophageal Squamous Cell Carcinoma via an Oxidative and Mitochondrial-Dependent Pathway
AbstractBackgroundα-Hederin has been shown promising anti-tumor potential against various cancer cell lines. However, reports about effects of α-hederin on esophageal squamous cell carcinoma (ESCC) are still unavailable.AimTo investigate the inhibitory effects of α-hederin on ESCC and explore the underlying mechanism.MethodsHuman esophageal carcinoma cell line (Eca-109) was used for the experiment. Cell Counting Kit-8, flow cytometry, Hoechst 33258 staining, enhanced ATP assay kit, 2 ′,7′-dichlorofluorescin diacetate, JC-1 kit, and Western bolt were used to assess the cell viability, cycle, ap...
Source: Digestive Diseases and Sciences - July 4, 2019 Category: Gastroenterology Source Type: research

EZH2 Regulates Intestinal Inflammation and Necroptosis Through the JNK Signaling Pathway in Intestinal Epithelial Cells
ConclusionOur data suggest that EZH2 plays an important role in the development of intestinal inflammation and necroptosis. Hence, EZH2 could be a potential therapeutic target for IBD. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - July 4, 2019 Category: Gastroenterology Source Type: research

Do Vigorous Esophageal Contractions Contribute to Rigorous Phenotyping of Gastroesophageal Reflux Disease?
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - July 4, 2019 Category: Gastroenterology Source Type: research

Climbing New Mountains: How Antibodies Blocking α4β7 Integrins Tamed Eosinophilic Inflammation of the Intestinal Tract
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - July 4, 2019 Category: Gastroenterology Source Type: research

Proximal Sessile Polyps: Raised Expectations for the Detection of Flat Lesions
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - July 4, 2019 Category: Gastroenterology Source Type: research

Concise Commentary: Antibiotic Prophylaxis for Endoscopic Needle Aspiration of Pancreatic Cystic Lesions: Bursting the Bubble?
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - July 4, 2019 Category: Gastroenterology Source Type: research

Treatment of Long-Limb Biliary-Enteric Anastomotic Strictures: ERCP, PTBD, or EUS?
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - July 4, 2019 Category: Gastroenterology Source Type: research

Efficacy of Infliximab in Crohn ’s Disease Patients with Prior Primary-Nonresponse to Tumor Necrosis Factor Antagonists
ConclusionsPatients with moderate –severe CD with prior primary-nonresponse to SC, fixed-dose TNFs, subsequently treated with IV, weight-based TNF have high rates of clinical and endoscopic response and remission. Therefore, despite primary-nonresponse to SC TNFs, patients may benefit from IV TNF therapy and may not require a chan ge to a different class of biologic therapy. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - June 20, 2019 Category: Gastroenterology Source Type: research

At the Junction of Immunity and Barrier Function: The Immunomodulatory Protein TL1A May Also Regulate Intestinal Permeability
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - June 20, 2019 Category: Gastroenterology Source Type: research

Letter to the Editor: “Gastric Per Oral Endoscopic Myotomy (G-POEM) for the Treatment of Refractory Gastroparesis: Early Experience”
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - June 20, 2019 Category: Gastroenterology Source Type: research

CT in Crohn ’s Disease Is Beneficial for Patient Care and Should Not Be Feared
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - June 20, 2019 Category: Gastroenterology Source Type: research

Effectiveness of Sterilized Symbiotic Drink Containing Lactobacillus helveticus Comparable to Probiotic Alone in Patients with Constipation-Predominant Irritable Bowel Syndrome
This study aimed to objectively investigate whether the addition of polydextrose to sterilized probiotic containingLactobacillus helveticus will confer benefits to constipation-predominant irritable bowel syndrome patients.MethodsA total of 163 patients were randomized into two groups: Group A to consume 350  mL of sterilized probiotic with 5.85 g polydextrose daily for 1 week and Group B without polydextrose. Intestinal transit time, fecal pH, fecal weight, and modifiedGarrigues questionnaires for pre- and post-consumption were assessed.ResultsMedian intestinal transit time was significantly reduced from 58...
Source: Digestive Diseases and Sciences - June 17, 2019 Category: Gastroenterology Source Type: research

Performance of Controlled Attenuation Parameter in Patients with Advanced Chronic Liver Disease and Portal Hypertension
AbstractBackgroundLiver stiffness (LS) measured by vibration-controlled transient elastography (VCTE) is influenced by liver fibrosis and hepatic perfusion pressure. VCTE-based controlled attenuation parameter (CAP) is a noninvasive marker for hepatic steatosis (HS).AimsTo investigate the diagnostic performance of CAP in patients with advanced chronic liver disease (ACLD)/portal hypertension (PHT: hepatic venous pressure gradient (HVPG)  ≥ 6 mmHg).MethodsEighty-eight patients with LS  ≥ 10 kPa and/or HVPG ≥ 6 mmHg who underwent simultaneous liver biopsy, CAP...
Source: Digestive Diseases and Sciences - June 17, 2019 Category: Gastroenterology Source Type: research

Efficacy of Probiotics and Synbiotics in Patients with Nonalcoholic Fatty Liver Disease: A Meta-Analysis
This study analyzed 15 randomized, controlled trials involving 782 patients with NAFLD. Probiotics and synbiotics supplementation could significantly improve liver steatosis, alanine aminotransferase, aspartate aminotransferase, triglyceride, total cholesterol, high-density lipoprotein, low-density lipoprotein, homeostasis model assessment-insulin resistance, liver stiffness and tumor necrosis factor-alpha (allP  
Source: Digestive Diseases and Sciences - June 15, 2019 Category: Gastroenterology Source Type: research

Subcapsular Hepatic Hematoma Post-ERCP: Case Report and Review of the Literature
We describe the case of a 75-year old man with a large, 8 × 12 cm, sub-capsular and intra-parenchymal hematoma post ERCP, affecting the right liver segments and treated conservatively.Areas coveredA review of literature has been performed, highlighting two possible mechanisms: hematoma may occur as the result of accidental laceration of a small intrahepatic vessel by the guidewire, whereas the other hypothesis posits that the hepatic damage is secondary to traction on the biliary system exerted by the balloon. We speculate that in case of anomalies of the biliary tree, the incidence of this complication is higher tha...
Source: Digestive Diseases and Sciences - June 13, 2019 Category: Gastroenterology Source Type: research

A Risk Assessment of Factors for the Presence of Angiodysplasias During Endoscopy and Factors Contributing to Symptomatic Bleeding and Rebleeds
AbstractBackgroundFew studies have assessed factors associated with angiodysplasias during endoscopy or factors associated with symptomatic disease.AimsTo evaluate risk factors for the presence of and contribution to symptomatic disease in patients with angiodysplasias.MethodsWe performed a systematic MEDLINE, EMBASE and Cochrane Library search according to the PRISMA guidelines for studies assessing risk factors involved in angiodysplasias detected during endoscopy and factors that lead to anemia or overt bleeding. Study quality was assessed with the Newcastle –Ottawa scale. A risk assessment was performed by select...
Source: Digestive Diseases and Sciences - June 12, 2019 Category: Gastroenterology Source Type: research

Resolution of Refractory Eosinophilic Esophagitis with the Leukocyte-Trafficking Inhibitor Natalizumab
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - June 12, 2019 Category: Gastroenterology Source Type: research

DDS-SIRC Collaboration: L ’Inizio di una Bella Amicizia
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - June 12, 2019 Category: Gastroenterology Source Type: research

Suboptimal Adherence in Clinical Practice to Guidelines Recommendation to Screen for Lynch Syndrome
AbstractBackgroundIdentification of Lynch syndrome (LS) followed by annual/biannual surveillance colonoscopy markedly reduces the risk of developing new colorectal cancer (CRC) among those with LS.Aims(1) To determine the current practice of identifying LS in the USA and Canada, and current surveillance and management practices for those diagnosed with LS; (2) to determine whether variances in current practice are physician/region dependent or influenced by ease of access to specialist clinics.MethodsAn online survey request was sent to practicing gastroenterologists through the Canadian Association of Gastroenterology and...
Source: Digestive Diseases and Sciences - June 11, 2019 Category: Gastroenterology Source Type: research

Transarterial Chemoembolization in Treatment-Na ïve and Recurrent Hepatocellular Carcinoma: A Propensity-Matched Outcome Analysis
AbstractObjectivesTransarterial chemoembolization (TACE) improves the survival of patients with hepatocellular carcinoma (HCC); however, TACE treatment outcomes of patients with treatment-na ïve HCC (TN-HCC) and those with recurrent HCC after curative resection (R-HCC) have not yet been compared.MethodsWe recruited 448 patients with TN-HCC, and 275 patients with R-HCC treated with TACE as first-line anti-cancer treatment.ResultsAt first TACE, patients with TN-HCC showed a significantly lower proportion of male gender (74.9% vs. 84.3%), higher proportion of liver cirrhosis (61.9% vs. 49.3%), higher aspartate aminotrans...
Source: Digestive Diseases and Sciences - June 11, 2019 Category: Gastroenterology Source Type: research

Ustekinumab Is Effective for the Treatment of Chronic Antibiotic-Refractory Pouchitis
ConclusionsThis is the largest study of ustekinumab treatment for patients with chronic antibiotic-refractory pouchitis. We found that ustekinumab therapy led to the improvement in clinical and endoscopic endpoints. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - June 11, 2019 Category: Gastroenterology Source Type: research

Retrospective Analysis Confirms Tetracycline Quadruple as Best Helicobacter pylori Regimen in the USA
ConclusionQuadruple therapy is superior to triple therapy within the Rhode Island population. Fourteen-day therapy achieves superior eradication compared to 10-day therapy, and doxycycline is inferior to tetracycline for quadruple therapy. Our findings support adherence to ACG and international guidelines advising 14-day quadruple therapy. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - June 11, 2019 Category: Gastroenterology Source Type: research

Awareness of Nonalcoholic Fatty Liver Disease Is Increasing but Remains Very Low in a Representative US Cohort
AbstractBackgroundNonalcoholic fatty liver disease (NAFLD) has become the most common form of chronic liver disease in the USA. Interestingly, most patients with NAFLD are unaware of having any liver disease (LD). We aimed to assess the awareness of suspected NAFLD and factors associated with being aware of LD.MethodsAdult subjects with suspected NAFLD (BMI  >  25) with elevated ALT in the absence of secondary causes of LD who participated in the continuous national health and nutrition examination survey (NHANES) during 2001–2016 were identified and analyzed. Trends of NAFLD awareness were then asse...
Source: Digestive Diseases and Sciences - June 11, 2019 Category: Gastroenterology Source Type: research

Percutaneous Endoscopic Step-Up Therapy Is an Effective Minimally Invasive Approach for Infected Necrotizing Pancreatitis
ConclusionPercutaneous endoscopic step-up therapy is an effective strategy for IPN. Organ failure and extensive pancreatic necrosis predicted a suboptimal outcome in patients with infected necrotizing pancreatitis. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - June 11, 2019 Category: Gastroenterology Source Type: research

Impairment of Nrf2- and Nitrergic-Mediated Gastrointestinal Motility in an MPTP Mouse Model of Parkinson ’s Disease
ConclusionsLoss of Nrf2/BH4/nNOS expression in PD impairs antioxidant gene expression, which deregulates NO synthesis, thereby contributing to the development of GI dysmotility and constipation. Nitric oxide appears to be important to maintain dopamine synthesis in the colon. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - June 11, 2019 Category: Gastroenterology Source Type: research

Foregone Inclusion: Neonatal CMV Hepatitis and Cholestasis
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - June 11, 2019 Category: Gastroenterology Source Type: research

EUS-Guided Choledochoduodenostomy for Distal Malignant Biliary Obstruction Using Electrocautery-Enhanced Lumen-Apposing Metal Stents: First US, Multicenter Experience
ConclusionEUS-CD using LAMS with cautery-enhanced delivery systems has high technical and clinical success rates, with a low rate of adverse events. Inserting an axis-orienting stent through the lumen of the LAMS may reduce the need for biliary re-interventions. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - June 7, 2019 Category: Gastroenterology Source Type: research

Epidemiology of Colorectal Cancer in Average Risk Adults 20 –39 Years of Age: A Population-Based National Study
ConclusionThis is one of the largest studies to date to describe the epidemiology of EoCRC in USA. We found EoCRC to occur predominantly in the Caucasian and female population. EoCRC presented more frequently with left-sided and rectal CRC. We also identified signs/symptoms as well as comorbidities associated with EoCRC. Patients with these features may benefit from earlier screening. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - June 7, 2019 Category: Gastroenterology Source Type: research

Improving Acute GI Bleeding Management Through Artificial Intelligence: Unnatural Selection?
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - June 7, 2019 Category: Gastroenterology Source Type: research

Computer-Assisted Propofol Sedation for Esophagogastroduodenoscopy Is Effective, Efficient, and Safe
AbstractBackground and AimsComputer-assisted propofol sedation (CAPS) allows non-anesthesiologists to administer propofol for gastrointestinal procedures in relatively healthy patients. As the first US medical center to adopt CAPS technology for routine clinical use, we report our 1-year experience with CAPS for esophagogastroduodenoscopy (EGD).MethodsBetween September 2014 and August 2015, 926 outpatients underwent elective EGDs with CAPS at our center. All EGDs were performed by 1 of 17 gastroenterologists certified in the use of CAPS. Procedural success rates, procedure times, and recovery times were compared against co...
Source: Digestive Diseases and Sciences - June 4, 2019 Category: Gastroenterology Source Type: research

EndoClot ® SIS Polysaccharide Injection as a Submucosal Fluid Cushion for Endoscopic Mucosal Therapies: Results of Ex Vivo and In Vivo Studies
ConclusionSubmucosally injected EndoClot®SIS polysaccharide increased the effective separation of the mucosa and submucosa and reduced surgical complications. Hence, EndoClot®SIS polysaccharide injection is a safe and effective submucosal injection material. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - June 4, 2019 Category: Gastroenterology Source Type: research

Exocrine Pancreatic Insufficiency Following Acute Pancreatitis: Systematic Review and Meta-Analysis
ConclusionsThe prevalence of EPI during admission and follow-up is substantial in patients with a first attack of AP. Unanswered questions remain about the way this is managed, and further RCTs are indicated. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - June 4, 2019 Category: Gastroenterology Source Type: research