Concise Commentary: Bloating in IBS: Can We Burst the Bubble?
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 9, 2024 Category: Gastroenterology Source Type: research
Chemokines and Their Receptors: Predictors of Therapeutic Potential in Tumor Microenvironment on Esophageal Cancer
This article introduces the general structures and functions of CC, CXC chemokines and their receptors in TME, as well as their roles in the progress of ESCA. Chemokines are involved in the development of ESCA, such as cancer cell invasion, metastasis, angiogenesis, and radioresistance, and are key determinants of disease progression, which have a great impact on patient prognosis and treatment response. In addition, a full understanding of their mechanism of action is essential to further verify that these chemokines and their receptors may serve as biomarkers or therapeutic targets of ESCA.Graphical AbstractThe poor prog...
Source: Digestive Diseases and Sciences - April 5, 2024 Category: Gastroenterology Source Type: research
Adverse Events and Device Failures Associated with Pancreatic Stents: A Comprehensive Analysis Using the FDA ’s MAUDE Database
ConclusionOur findings highlight important device and patient adverse events that endoscopists and referring providers should be aware of before considering pancreatic stent placement.Graphical Abstract (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 5, 2024 Category: Gastroenterology Source Type: research
Direct-Acting Antiviral Therapy for Patients with Chronic Hepatitis C Infection and Decompensated Cirrhosis
AbstractPatients with chronic hepatitis C virus (HCV) infection and decompensated cirrhosis are an important population for antiviral therapy yet under-represented in clinical trials. HCV direct-acting antiviral (DAA) therapies, unlike interferon-containing regimens, can be safely utilized in decompensated patients. Per guidelines from the American Association for the Study of Liver Diseases (AASLD), therapy of choice in HCV and decompensated cirrhosis is sofosbuvir, an HCV polymerase inhibitor, combined with a replication complex inhibitor (NS5A inhibitor) with or without ribavirin. Combination therapy with a HCV protease...
Source: Digestive Diseases and Sciences - April 5, 2024 Category: Gastroenterology Source Type: research
Correlation Between Serum and Fecal Biomarkers and Patient-Reported Outcomes in Patients with Crohn ’s Disease and Ulcerative Colitis
ConclusionPROs correlate with CRP and FCP; however, disease location and phenotype impact their ability to distinguish symptom severity. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 5, 2024 Category: Gastroenterology Source Type: research
Chemokines and Their Receptors: Predictors of Therapeutic Potential in Tumor Microenvironment on Esophageal Cancer
This article introduces the general structures and functions of CC, CXC chemokines and their receptors in TME, as well as their roles in the progress of ESCA. Chemokines are involved in the development of ESCA, such as cancer cell invasion, metastasis, angiogenesis, and radioresistance, and are key determinants of disease progression, which have a great impact on patient prognosis and treatment response. In addition, a full understanding of their mechanism of action is essential to further verify that these chemokines and their receptors may serve as biomarkers or therapeutic targets of ESCA.Graphical AbstractThe poor prog...
Source: Digestive Diseases and Sciences - April 5, 2024 Category: Gastroenterology Source Type: research
Adverse Events and Device Failures Associated with Pancreatic Stents: A Comprehensive Analysis Using the FDA ’s MAUDE Database
ConclusionOur findings highlight important device and patient adverse events that endoscopists and referring providers should be aware of before considering pancreatic stent placement.Graphical Abstract (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 5, 2024 Category: Gastroenterology Source Type: research
Direct-Acting Antiviral Therapy for Patients with Chronic Hepatitis C Infection and Decompensated Cirrhosis
AbstractPatients with chronic hepatitis C virus (HCV) infection and decompensated cirrhosis are an important population for antiviral therapy yet under-represented in clinical trials. HCV direct-acting antiviral (DAA) therapies, unlike interferon-containing regimens, can be safely utilized in decompensated patients. Per guidelines from the American Association for the Study of Liver Diseases (AASLD), therapy of choice in HCV and decompensated cirrhosis is sofosbuvir, an HCV polymerase inhibitor, combined with a replication complex inhibitor (NS5A inhibitor) with or without ribavirin. Combination therapy with a HCV protease...
Source: Digestive Diseases and Sciences - April 5, 2024 Category: Gastroenterology Source Type: research
Correlation Between Serum and Fecal Biomarkers and Patient-Reported Outcomes in Patients with Crohn ’s Disease and Ulcerative Colitis
ConclusionPROs correlate with CRP and FCP; however, disease location and phenotype impact their ability to distinguish symptom severity. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 5, 2024 Category: Gastroenterology Source Type: research
Integrated Analysis Construct a Tumor-Associated Macrophage Novel Signature with Promising Implications in Predicting the Prognosis and Immunotherapeutic Response of Gastric Cancer Patients
ConclusionsThe prognosis of GC can be effectively predicted by TAM-based risk signatures, and the signature may provide a new perspective for comprehensively guiding clinical diagnosis, prediction, and immunotherapy for gastric cancer. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 4, 2024 Category: Gastroenterology Source Type: research
Ozanimod Differentially Impacts Circulating Lymphocyte Subsets in Patients with Moderately to Severely Active Crohn ’s Disease
ConclusionsOzanimod reduced circulating levels of all B-cell and most T-cell subsets but not monocytes or natural killer cells. Key subsets relevant to immune surveillance were not reduced, supporting the low risk of infection and malignancy with ozanimod in chronic inflammatory diseases. Levels of nonswitched memory B cells were associated with efficacy, providing a potential marker for ozanimod response.Trial Registration ClinicalTrials.gov: NCT02531113, EudraCT: 2015 –002025–19Graphical Abstract (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 3, 2024 Category: Gastroenterology Source Type: research
Pedigree Analysis of Nonclassical Cholesteryl Ester Storage Disease with Dominant Inheritance in a LIPA I378T Heterozygous Carrier
ConclusionsPhenotypic analyses indicate that this may be an autosomal dominant nonclassical CESD pedigree with aLIPA gene mutation. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 2, 2024 Category: Gastroenterology Source Type: research
Top Tips for Direct Percutaneous Endoscopic Jejunostomy (DPEJ) Tube Placement
AbstractDirect percutaneous endoscopic jejunostomy (DPEJ) provides post-pyloric enteral access in patients unable to meet long-term nutritional needsper os in situations where gastric feeding is neither tolerated nor feasible. Specific conditions associated with feeding intolerance due to due to nausea, vomiting, or ileus include gastric outlet obstruction, gastroparesis, or complications of acute or chronic pancreatitis; infeasibility may be due to high aspiration risk or prior gastric surgery. Since performing DPEJ is not an ACGME requirement for GI fellows or early career gastroenterologists, not all trainees are taught...
Source: Digestive Diseases and Sciences - April 2, 2024 Category: Gastroenterology Source Type: research
