Ozanimod Differentially Impacts Circulating Lymphocyte Subsets in Patients with Moderately to Severely Active Crohn ’s Disease
ConclusionsOzanimod reduced circulating levels of all B-cell and most T-cell subsets but not monocytes or natural killer cells. Key subsets relevant to immune surveillance were not reduced, supporting the low risk of infection and malignancy with ozanimod in chronic inflammatory diseases. Levels of nonswitched memory B cells were associated with efficacy, providing a potential marker for ozanimod response.Trial Registration ClinicalTrials.gov: NCT02531113, EudraCT: 2015 –002025–19Graphical Abstract (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 3, 2024 Category: Gastroenterology Source Type: research
Pedigree Analysis of Nonclassical Cholesteryl Ester Storage Disease with Dominant Inheritance in a LIPA I378T Heterozygous Carrier
ConclusionsPhenotypic analyses indicate that this may be an autosomal dominant nonclassical CESD pedigree with aLIPA gene mutation. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 2, 2024 Category: Gastroenterology Source Type: research
Top Tips for Direct Percutaneous Endoscopic Jejunostomy (DPEJ) Tube Placement
AbstractDirect percutaneous endoscopic jejunostomy (DPEJ) provides post-pyloric enteral access in patients unable to meet long-term nutritional needsper os in situations where gastric feeding is neither tolerated nor feasible. Specific conditions associated with feeding intolerance due to due to nausea, vomiting, or ileus include gastric outlet obstruction, gastroparesis, or complications of acute or chronic pancreatitis; infeasibility may be due to high aspiration risk or prior gastric surgery. Since performing DPEJ is not an ACGME requirement for GI fellows or early career gastroenterologists, not all trainees are taught...
Source: Digestive Diseases and Sciences - April 2, 2024 Category: Gastroenterology Source Type: research
Correction: Efficacy and Safety of Pea Protein and Xyloglucan Versus Simethicone in Functional Abdominal Bloating and Distension
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 2, 2024 Category: Gastroenterology Source Type: research
Correction to: Prevalence and Associated Dietary Factors of Rome IV Functional Gastrointestinal Disorders in Rural Western Honduras
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 2, 2024 Category: Gastroenterology Source Type: research
Pedigree Analysis of Nonclassical Cholesteryl Ester Storage Disease with Dominant Inheritance in a LIPA I378T Heterozygous Carrier
ConclusionsPhenotypic analyses indicate that this may be an autosomal dominant nonclassical CESD pedigree with aLIPA gene mutation. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 2, 2024 Category: Gastroenterology Source Type: research
Top Tips for Direct Percutaneous Endoscopic Jejunostomy (DPEJ) Tube Placement
AbstractDirect percutaneous endoscopic jejunostomy (DPEJ) provides post-pyloric enteral access in patients unable to meet long-term nutritional needsper os in situations where gastric feeding is neither tolerated nor feasible. Specific conditions associated with feeding intolerance due to due to nausea, vomiting, or ileus include gastric outlet obstruction, gastroparesis, or complications of acute or chronic pancreatitis; infeasibility may be due to high aspiration risk or prior gastric surgery. Since performing DPEJ is not an ACGME requirement for GI fellows or early career gastroenterologists, not all trainees are taught...
Source: Digestive Diseases and Sciences - April 2, 2024 Category: Gastroenterology Source Type: research
Correction: Efficacy and Safety of Pea Protein and Xyloglucan Versus Simethicone in Functional Abdominal Bloating and Distension
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 2, 2024 Category: Gastroenterology Source Type: research
Correction to: Prevalence and Associated Dietary Factors of Rome IV Functional Gastrointestinal Disorders in Rural Western Honduras
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 2, 2024 Category: Gastroenterology Source Type: research
Exclusive Yet Effective: The Crohn ’s Disease Exclusion Diet as Treatment for Medication-Refractory Disease
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 30, 2024 Category: Gastroenterology Source Type: research
Comparative Risks of Post-ERCP Adverse Events in Patients with Asymptomatic and Symptomatic Choledocholithiasis: A Systematic Review and Meta-Analysis
ConclusionsAsymptomatic patients with choledocholithiasis appear to have a higher risk of PEP than symptomatic patients, while the risk of other post-ERCP adverse events is similar between the two groups. Interventional endoscopists should thoroughly discuss potential adverse events (particularly PEP) with asymptomatic patients before performing ERCP and utilize PEP-prevention measures more liberally in this subgroup of patients. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 30, 2024 Category: Gastroenterology Source Type: research
A Case of Immunoglobulin Light Chain Hepatic Amyloidosis with Abdominal Hematoma
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 30, 2024 Category: Gastroenterology Source Type: research
Exclusive Yet Effective: The Crohn ’s Disease Exclusion Diet as Treatment for Medication-Refractory Disease
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 30, 2024 Category: Gastroenterology Source Type: research
Comparative Risks of Post-ERCP Adverse Events in Patients with Asymptomatic and Symptomatic Choledocholithiasis: A Systematic Review and Meta-Analysis
ConclusionsAsymptomatic patients with choledocholithiasis appear to have a higher risk of PEP than symptomatic patients, while the risk of other post-ERCP adverse events is similar between the two groups. Interventional endoscopists should thoroughly discuss potential adverse events (particularly PEP) with asymptomatic patients before performing ERCP and utilize PEP-prevention measures more liberally in this subgroup of patients. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 30, 2024 Category: Gastroenterology Source Type: research
