Like a Rolling (Gall)Stone: Optimal Treatment of Gallstone Obstruction of the Sigmoid Colon
ConclusionA multidisciplinary discussion between endoscopists and surgeons is often needed to choose the best therapeutic option, especially in high-risk patients. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 11, 2024 Category: Gastroenterology Source Type: research
Interleukin-22 Alleviates Caerulein-Induced Acute Pancreatitis by Activating AKT/mTOR Pathway
ConclusionThis study suggests that Interleukin -22 administration could alleviate pancreatic damage in caerulein-induced acute pancreatitis. This effect may result from the activation of the AKT/mTOR pathway, leading to the inhibition of autophagy. Consequently, Interleukin -22 shows potential as a treatment. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 11, 2024 Category: Gastroenterology Source Type: research
Impact of COVID-19 Treatment on Real-World Outcomes in Inflammatory Bowel Disease
ConclusionsPatients with IBD on advanced therapies were frequently treated for acute COVID-19. Although COVID-19 treatment was associated with temporary withholding of IBD therapy, it did not result in increased IBD flares. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 11, 2024 Category: Gastroenterology Source Type: research
Getting the Bugs Out: Disposable Duodenoscopes Have a Shallower Learning Curve but Face a Steep Climb in Usability
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 11, 2024 Category: Gastroenterology Source Type: research
Bile Culture May Guide Antibiotic Stewardship in Acute Bacterial Cholangitis
ConclusionBile and blood cultures have a similar microbial profile in most patients with cholangitis. As bile cultures have a significantly higher yield than blood cultures, they could effectively guide antimicrobial therapy, especially in those with negative blood cultures.Graphical Abstract (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 8, 2024 Category: Gastroenterology Source Type: research
Food-Related Quality of Life and Its Predictors in Inflammatory Bowel Disease
ConclusionsPatients with IBD showed significant FR-QoL impairment, irrespective of disease type and activity. Related psychosocial factors, such as the patient ’s affective status and fear around eating, warrant a need for a multidisciplinary approach to IBD, including tailored nutritional counseling. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 8, 2024 Category: Gastroenterology Source Type: research
Successful Treatment of Recurrent Clostridioides difficile Infection Using a Novel, Drinkable, Oral Formulation of Fecal Microbiota
ConclusionWe developed a novel organoleptically acceptable liquid formulation of fecal microbiota that is suitable for use in clinical trials for patients with difficulties in swallowing capsules. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 8, 2024 Category: Gastroenterology Source Type: research
Bile Culture May Guide Antibiotic Stewardship in Acute Bacterial Cholangitis
ConclusionBile and blood cultures have a similar microbial profile in most patients with cholangitis. As bile cultures have a significantly higher yield than blood cultures, they could effectively guide antimicrobial therapy, especially in those with negative blood cultures.Graphical Abstract (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 8, 2024 Category: Gastroenterology Source Type: research
Food-Related Quality of Life and Its Predictors in Inflammatory Bowel Disease
ConclusionsPatients with IBD showed significant FR-QoL impairment, irrespective of disease type and activity. Related psychosocial factors, such as the patient ’s affective status and fear around eating, warrant a need for a multidisciplinary approach to IBD, including tailored nutritional counseling. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 8, 2024 Category: Gastroenterology Source Type: research
Successful Treatment of Recurrent Clostridioides difficile Infection Using a Novel, Drinkable, Oral Formulation of Fecal Microbiota
ConclusionWe developed a novel organoleptically acceptable liquid formulation of fecal microbiota that is suitable for use in clinical trials for patients with difficulties in swallowing capsules. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 8, 2024 Category: Gastroenterology Source Type: research
Development and Validation of Case-Finding Algorithms to Identify Pancreatic Cancer in the Veterans Health Administration
ConclusionsAn algorithm incorporating readily available EHR data elements to identify patients with PDAC achieved excellent PPV and NPV. This algorithm is likely to enable future epidemiologic studies of PDAC.Graphic Abstract (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 7, 2024 Category: Gastroenterology Source Type: research
Development of a Serum-Based MicroRNA Signature for Early Detection of Pancreatic Cancer: A Multicenter Cohort Study
ConclusionsA panel of four serum miRNAs was developed showing remarkably discriminative ability of early stage PCa from either healthy controls or other pancreatic diseases, suggesting it may be developed as a novel, noninvasive approach for early screening of PCa in clinic.Graphical Abstract (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 7, 2024 Category: Gastroenterology Source Type: research
Healthcare Resource Utilization and Goals of Care Discussions in Patients with Cirrhosis and Acute Kidney Injury
ConclusionGoals of care discussions occurred late into the hospital course, after episodes of HCRU. Efforts should be made to engage in these discussions earlier in the hospital stay, which may decrease HCRU rates in this critically ill population and align with patients ’ goals of care. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 7, 2024 Category: Gastroenterology Source Type: research
A New Look at Goals-of-Care Discussions in Patients with Cirrhosis and Acute Kidney Injury
(Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 7, 2024 Category: Gastroenterology Source Type: research
Development and Validation of Case-Finding Algorithms to Identify Pancreatic Cancer in the Veterans Health Administration
ConclusionsAn algorithm incorporating readily available EHR data elements to identify patients with PDAC achieved excellent PPV and NPV. This algorithm is likely to enable future epidemiologic studies of PDAC.Graphic Abstract (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 7, 2024 Category: Gastroenterology Source Type: research
