Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions
World J Gastroenterol. 2024 Apr 14;30(14):1968-1981. doi: 10.3748/wjg.v30.i14.1968.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is the most prevalent type of chronic liver disease. However, the disease is underappreciated as a remarkable chronic disorder as there are rare managing strategies. Several studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoetiology and suggest functional therapeutic and diagnostic options. Pyroptosis, ferroptosis, and necroptosis are the main subtypes of non-apoptotic regulated cell deaths (RCDs), each of which represents particular characteristic...
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Hong-Ju Sun Bo Jiao Yan Wang Yue-Hua Zhang Ge Chen Zi-Xuan Wang Hong Zhao Qing Xie Xiao-Hua Song Source Type: research
Prevalence and predictive features of metabolic dysfunction-associated steatotic liver disease in type 1 diabetes
CONCLUSION: Individuals with type 1 diabetes and high blood pressure, older age, BMI and duration of disease could be considered at high-risk for developing MASLD.PMID:38679966 | DOI:10.1093/ejendo/lvae043 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 29, 2024 Category: Endocrinology Authors: Coco M Fuhri Snethlage Abraham S Meijnikman Anne Linde Mak Elena Rampanelli Bas Voermans Cengiz A K Callender Pleun de Groen Bart O Roep Dani ël H van Raalte Filip K Knop Adriaan G Holleboom Max Nieuwdorp Nordin M J Hanssen Source Type: research
Interplay between metabolic dysfunction-associated fatty liver disease and renal function: An intriguing pediatric perspective
World J Gastroenterol. 2024 Apr 21;30(15):2081-2086. doi: 10.3748/wjg.v30.i15.2081.ABSTRACTOver recent years, the nomenclature of non-alcoholic fatty liver disease has undergone significant changes. Indeed, in 2020, an expert consensus panel proposed the term "Metabolic (dysfunction) associated fatty liver disease" (MAFLD) to underscore the close association of fatty liver with metabolic abnormalities, thereby highlighting the cardiometabolic risks (such as metabolic syndrome, type 2 diabetes, insulin resistance, and cardiovascular disease) faced by these patients since childhood. More recently, this term has been further ...
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Michele Nardolillo Fabiola Rescigno Mario Bartiromo Dario Piatto Stefano Guarino Pierluigi Marzuillo Emanuele Miraglia Del Giudice Anna Di Sessa Source Type: research
Omics-based biomarkers as useful tools in metabolic dysfunction-associated steatotic liver disease clinical practice: How far are we?
This article presents an overview of this area's current state, the conceivable opportunities and challenges of omics-based laboratory diagnostics, and a roadmap for improving MASLD biomarker research.PMID:38681130 | PMC:PMC11045490 | DOI:10.3748/wjg.v30.i14.1982 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Julieta Trinks Mar ía F Mascardi Adri án Gadano Sebasti án Marciano Source Type: research
Liver biopsy in the post-hepatitis C virus era in Japan
In conclusion, pathologists should be attuned to the changing landscape of liver diseases and approach liver biopsies with care and attention to detail.PMID:38681127 | PMC:PMC11045496 | DOI:10.3748/wjg.v30.i14.1949 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Yoshihiro Ikura Takako Okubo Yasuhiro Sakai Source Type: research
Current status of liver transplantation for human immunodeficiency virus-infected patients in mainland China
This study provides an overview of the current landscape of HIV-positive patients receiving liver transplantation (LT) in mainland China. To date, our transplant center has conducted LT for eight end-stage liver disease patients co-infected with HIV, and all but one, who died two months postoperatively due to sepsis and progressive multi-organ failure, have survived. Comparative analysis with hepatitis B virus-infected patients during the same period revealed no statistically significant differences in acute rejection reactions, cytomegalovirus infection, bacteremia, pulmonary infections, acute kidney injury, new-onset can...
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Jian-Xin Tang Dong Zhao Source Type: research
Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions
World J Gastroenterol. 2024 Apr 14;30(14):1968-1981. doi: 10.3748/wjg.v30.i14.1968.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is the most prevalent type of chronic liver disease. However, the disease is underappreciated as a remarkable chronic disorder as there are rare managing strategies. Several studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoetiology and suggest functional therapeutic and diagnostic options. Pyroptosis, ferroptosis, and necroptosis are the main subtypes of non-apoptotic regulated cell deaths (RCDs), each of which represents particular characteristic...
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Hong-Ju Sun Bo Jiao Yan Wang Yue-Hua Zhang Ge Chen Zi-Xuan Wang Hong Zhao Qing Xie Xiao-Hua Song Source Type: research
Targeted Knockdown of Hepatic delta-5 Fatty Acid Desaturase FADS1 Aggravates Atherosclerosis in ApoE(-/-) Mice
CONCLUSIONS: Our study demonstrated that knockdown of hepatic Fads1 in ApoE-/- mice aggravates spontaneous atherosclerosis and NAFLD but does not affect peripheral atherosclerosis (femoral artery) induced by vascular cuff combined with tandem stenosis.PMID:38682200 | DOI:10.31083/j.fbl2904131 (Source: Atherosclerosis)
Source: Atherosclerosis - April 29, 2024 Category: Cardiology Authors: Qiulei Liu Peng Wang Zhao Yang Yue Dai Sheng Wang Source Type: research
Delineating the heterogeneity of senescence-induced-functional alterations in hepatocytes
CONCLUSION: In our study, we demonstrated that each senescence inducer activates a unique combination of senescence markers in PMH. Doxorubicin demonstrated the highest efficacy in inducing senescence, followed by cisplatin and H2O2, with no impact on apoptosis. Each inducer prompted DNA damage response and mitochondrial dysfunction, independent of MAPK/AKT.PMID:38684535 | DOI:10.1007/s00018-024-05230-2 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - April 29, 2024 Category: Cytology Authors: Pavitra Kumar Mohsin Hassan Frank Tacke Cornelius Engelmann Source Type: research
Decoding bioactive signals of the RNA secretome: the cell-free messenger RNA catalogue
Expert Rev Mol Med. 2024 Apr 29;26:e12. doi: 10.1017/erm.2024.12.ABSTRACTDespite gene-expression profiling being one of the most common methods to evaluate molecular dysregulation in tissues, the utilization of cell-free messenger RNA (cf-mRNA) as a blood-based non-invasive biomarker analyte has been limited compared to other RNA classes. Recent advancements in low-input RNA-sequencing and normalization techniques, however, have enabled characterization as well as accurate quantification of cf-mRNAs allowing direct pathological insights. The molecular profile of the cell-free transcriptome in multiple diseases has subseque...
Source: Molecular Medicine - April 29, 2024 Category: Molecular Biology Authors: Rhys E De Sota Stephen R Quake John J Sninsky Shusuke Toden Source Type: research
Interplay between metabolic dysfunction-associated fatty liver disease and renal function: An intriguing pediatric perspective
World J Gastroenterol. 2024 Apr 21;30(15):2081-2086. doi: 10.3748/wjg.v30.i15.2081.ABSTRACTOver recent years, the nomenclature of non-alcoholic fatty liver disease has undergone significant changes. Indeed, in 2020, an expert consensus panel proposed the term "Metabolic (dysfunction) associated fatty liver disease" (MAFLD) to underscore the close association of fatty liver with metabolic abnormalities, thereby highlighting the cardiometabolic risks (such as metabolic syndrome, type 2 diabetes, insulin resistance, and cardiovascular disease) faced by these patients since childhood. More recently, this term has been further ...
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Michele Nardolillo Fabiola Rescigno Mario Bartiromo Dario Piatto Stefano Guarino Pierluigi Marzuillo Emanuele Miraglia Del Giudice Anna Di Sessa Source Type: research
Omics-based biomarkers as useful tools in metabolic dysfunction-associated steatotic liver disease clinical practice: How far are we?
This article presents an overview of this area's current state, the conceivable opportunities and challenges of omics-based laboratory diagnostics, and a roadmap for improving MASLD biomarker research.PMID:38681130 | PMC:PMC11045490 | DOI:10.3748/wjg.v30.i14.1982 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Julieta Trinks Mar ía F Mascardi Adri án Gadano Sebasti án Marciano Source Type: research
Liver biopsy in the post-hepatitis C virus era in Japan
In conclusion, pathologists should be attuned to the changing landscape of liver diseases and approach liver biopsies with care and attention to detail.PMID:38681127 | PMC:PMC11045496 | DOI:10.3748/wjg.v30.i14.1949 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Yoshihiro Ikura Takako Okubo Yasuhiro Sakai Source Type: research
Current status of liver transplantation for human immunodeficiency virus-infected patients in mainland China
This study provides an overview of the current landscape of HIV-positive patients receiving liver transplantation (LT) in mainland China. To date, our transplant center has conducted LT for eight end-stage liver disease patients co-infected with HIV, and all but one, who died two months postoperatively due to sepsis and progressive multi-organ failure, have survived. Comparative analysis with hepatitis B virus-infected patients during the same period revealed no statistically significant differences in acute rejection reactions, cytomegalovirus infection, bacteremia, pulmonary infections, acute kidney injury, new-onset can...
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Jian-Xin Tang Dong Zhao Source Type: research
Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions
World J Gastroenterol. 2024 Apr 14;30(14):1968-1981. doi: 10.3748/wjg.v30.i14.1968.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is the most prevalent type of chronic liver disease. However, the disease is underappreciated as a remarkable chronic disorder as there are rare managing strategies. Several studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoetiology and suggest functional therapeutic and diagnostic options. Pyroptosis, ferroptosis, and necroptosis are the main subtypes of non-apoptotic regulated cell deaths (RCDs), each of which represents particular characteristic...
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Hong-Ju Sun Bo Jiao Yan Wang Yue-Hua Zhang Ge Chen Zi-Xuan Wang Hong Zhao Qing Xie Xiao-Hua Song Source Type: research
