Delineating the heterogeneity of senescence-induced-functional alterations in hepatocytes

CONCLUSION: In our study, we demonstrated that each senescence inducer activates a unique combination of senescence markers in PMH. Doxorubicin demonstrated the highest efficacy in inducing senescence, followed by cisplatin and H2O2, with no impact on apoptosis. Each inducer prompted DNA damage response and mitochondrial dysfunction, independent of MAPK/AKT.PMID:38684535 | DOI:10.1007/s00018-024-05230-2
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Source Type: research