Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes
ConclusioncircSOD2 competitively sponges miR-532-3p to activate the TXNIP/NLRP3 inflammasome signaling pathway, promoting pyroptosis in NAFLD. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 24, 2024 Category: Research Source Type: research
Assessment of fatigue and its impact in chronic liver disease
Patient reported outcomes (PROs) such as health related quality of life (HRQL) are important outcome measures for patients with chronic liver diseases (CLDs). Presence of cirrhosis and advanced liver disease have been associated with worsened HRQL and fatigue. On the other hand, some patients with earlier stages of CLD such as primary biliary cholangitis (PBC), chronic hepatitis C viral infection (HCV) and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), also experience fatigue causing PRO impairment. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 24, 2024 Category: Gastroenterology Authors: Zobair M. Younossi, Andreas E. Kremer, Mark G. Swain, David Jones, Christopher Bowlus, Michael Trauner, Linda Henry, Lynn Gerber Tags: Research Article Source Type: research
Serum vitamins and homocysteine levels in autoimmune liver disease: A systematic review and meta ‐analysis
ConclusionMost vitamins are deficient in AILD, so appropriate vitamin supplementation should be necessary. Further studies with larger sample sizes are needed to validate these findings. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 23, 2024 Category: Allergy & Immunology Authors: Jiahuan Li,
Shan Tian,
Bai Ci,
Yuwen Xi,
Xiaoling Deng Tags: REVIEW ARTICLE Source Type: research
Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
This article reviews the recent research progress of GLP-1 in lipid metabolism.PMID:38650100 | DOI:10.4093/dmj.2023.0277 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 23, 2024 Category: Endocrinology Authors: Tong Bu Ziyan Sun Yi Pan Xia Deng Guoyue Yuan Source Type: research
Metabolic dysfunction-associated steatotic liver disease: Evolution of the final terminology
Eur J Intern Med. 2024 Apr 22:S0953-6205(24)00173-0. doi: 10.1016/j.ejim.2024.04.013. Online ahead of print.ABSTRACTThe medical term nonalcoholic fatty liver disease (NAFLD) was coined in 1986 for a condition that has since become the most prevalent liver disorder worldwide. In the last 3 years, the global professional community launched 2 consecutive efforts to purge NAFLD from the medical dictionary and recommended new terms based on disease pathophysiology rather than distinction from similar conditions featuring liver steatosis. A consensus by renowned clinical scholars primarily residing in the Asian-Pacific region in...
Source: European Journal of Internal Medicine - April 23, 2024 Category: Internal Medicine Authors: Piero Portincasa Gyorgy Baffy Source Type: research
Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
This article reviews the recent research progress of GLP-1 in lipid metabolism.PMID:38650100 | DOI:10.4093/dmj.2023.0277 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 23, 2024 Category: Endocrinology Authors: Tong Bu Ziyan Sun Yi Pan Xia Deng Guoyue Yuan Source Type: research
Blockade of neutrophil extracellular trap components ameliorates cholestatic liver disease in Mdr2 (Abcb4) knockout mice
J Autoimmun. 2024 Apr 22;146:103229. doi: 10.1016/j.jaut.2024.103229. Online ahead of print.ABSTRACTPrimary sclerosing cholangitis (PSC) is an (auto)immune-mediated cholestatic liver disease with a yet unclear etiology. Increasing evidence points to an involvement of neutrophils in chronic liver inflammation and cirrhosis but also liver repair. Here, we investigate the role of the neutrophil extracellular trap (NET) component myeloperoxidase (MPO) and the therapeutic potential of DNase I and of neutrophil elastase (NE) inhibitor GW311616A on disease outcome in the multidrug resistance 2 knockout (Mdr2-/-) mouse, a PSC anim...
Source: Journal of Autoimmunity - April 23, 2024 Category: Allergy & Immunology Authors: Edith Hintermann Camilla Tondello Sina Fuchs Monika Bayer Josef M Pfeilschifter Richard Taubert Martin Mollenhauer Roland P J Oude Elferink Michael P Manns Urs Christen Source Type: research
Metabolic dysfunction-associated steatotic liver disease: Evolution of the final terminology
Eur J Intern Med. 2024 Apr 22:S0953-6205(24)00173-0. doi: 10.1016/j.ejim.2024.04.013. Online ahead of print.ABSTRACTThe medical term nonalcoholic fatty liver disease (NAFLD) was coined in 1986 for a condition that has since become the most prevalent liver disorder worldwide. In the last 3 years, the global professional community launched 2 consecutive efforts to purge NAFLD from the medical dictionary and recommended new terms based on disease pathophysiology rather than distinction from similar conditions featuring liver steatosis. A consensus by renowned clinical scholars primarily residing in the Asian-Pacific region in...
Source: European Journal of Internal Medicine - April 23, 2024 Category: Internal Medicine Authors: Piero Portincasa Gyorgy Baffy Source Type: research
Accelerated free-breathing liver fat and < mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" > < mml:mrow > < mml:msubsup > < mml:mi > R < /mml:mi > < mml:mn > 2 < /mml:mn > < mml:mo > * < /mml:mo > < /mml:msubsup > < /mml:mrow > < /mml:math > quantification using multi-echo stack-of-radial MRI with motion-resolved multidimensional regularized reconstruction: Initial retrospective evaluation
CONCLUSION: This proposed method may allow accelerated free-breathing liver PDFF and R 2 * $$ {\mathrm{R}}_2^{\ast } $$ mapping with reduced biases and variations.PMID:38650444 | DOI:10.1002/mrm.30117 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - April 23, 2024 Category: Radiology Authors: Xiaodong Zhong Marcel D Nickel Stephan A R Kannengiesser Brian M Dale Fei Han Chang Gao Shu-Fu Shih Qing Dai Omar Curiel Tsu-Chin Tsao Holden H Wu Vibhas Deshpande Source Type: research
Pharmacological inhibition of the Src homology phosphatase 2 confers partial protection in a mouse model of alcohol-associated liver disease
This study aims to investigate the effects of Shp2 inhibition and its validity using a preclinical mouse model of ALD. We report that the administration of SHP099, a potent and selective allosteric inhibitor of Shp2, partially ameliorated ethanol-induced hepatic injury, inflammation, and steatosis in mice. Additionally, Shp2 inhibition was associated with reduced ethanol-evoked activation of extracellular signal-regulated kinase (ERK), oxidative, and endoplasmic reticulum (ER) stress in the liver. Besides the liver, excessive alcohol consumption induces multi-organ injury and dysfunction, including the intestine. Notably, ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 23, 2024 Category: Drugs & Pharmacology Authors: Ming-Fo Hsu Shinichiro Koike Chang-Shan Chen Sonia M Najjar Tzu-Ching Meng Fawaz G Haj Source Type: research
Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
This article reviews the recent research progress of GLP-1 in lipid metabolism.PMID:38650100 | DOI:10.4093/dmj.2023.0277 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 23, 2024 Category: Endocrinology Authors: Tong Bu Ziyan Sun Yi Pan Xia Deng Guoyue Yuan Source Type: research
Neutrophil to albumin ratio: a biomarker in non-alcoholic fatty liver disease and with liver fibrosis
CONCLUSION: These findings highlight that the novel inflammatory biomarker, NAR, is a convenient and easily accessible non-invasive predictor for NAFLD and NAFLD with liver fibrosis.PMID:38650638 | PMC:PMC11033504 | DOI:10.3389/fnut.2024.1368459 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Banghe Bao Shuang Xu Peng Sun Liduan Zheng Source Type: research
Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation
This study investigated the role of adiposity-associated orphan G protein-coupled receptor 75 (GPR75) in liver lipid accumulation. We profiled Gpr75 expression and report that it is most abundant in the brain. Next, we generated the first single-cell-level analysis of Gpr75 and identified a subpopulation co-expressed with key appetite-regulating hypothalamic neurons. CRISPR-Cas9-deleted Gpr75 mice fed a palatable western diet high in fat adjusted caloric intake to remain in energy balance, thereby preventing NAFLD. Consistent with mouse results, analysis of whole-exome sequencing data from 428,719 individuals (UK Biobank) ...
Source: Cell Metabolism - April 23, 2024 Category: Cytology Authors: Alasdair Leeson-Payne Jean Iyinikkel Cameron Malcolm Brian Y H Lam Nadine Sommer Georgina K C Dowsett Pablo B Martinez de Morentin Dawn Thompson Alasdair Mackenzie Raffaella Chianese Katherine Kentistou Eugene J Gardner John R B Perry Felix Grassmann John Source Type: research
