Impact of a medical interview on the decision to switch from originator infliximab to its biosimilar in patients with inflammatory bowel disease
To lighten the burden on health-care spending, switching from the infliximab originator to a biosimilar in patients with inflammatory bowel disease (IBD) is advocated. However, the uptake of biosimilars lacks initiatives aimed at educating patients. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 23, 2019 Category: Gastroenterology Authors: Vincent Haghnejad, Catherine Le Berre, Yoann Dominique, Camille Zallot, Francis Guillemin, Laurent Peyrin-Biroulet Tags: Alimentary Tract Source Type: research

Reply to comment: Etiology of non-cirrhotic portal vein thrombosis in children: Few or many causes?
We would like to thank Dr. Primignani and Dr. Tosetti for their comment on our paper describing the largest cohort of children with non-cirrhotic portal vein thrombosis (PVT) reported so far [1]. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 21, 2019 Category: Gastroenterology Authors: Angelo Di Giorgio, Lorenzo D ’Antiga Tags: Correspondence Source Type: research

Are we choosing wisely for inflammatory bowel disease care? The IG-IBD choosing wisely campaign
The “Choosing Wisely” campaigns have the aim of promoting a better clinician-patient relationship. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 21, 2019 Category: Gastroenterology Authors: Marco Vincenzo Lenti, Alessandro Armuzzi, Fabiana Castiglione, Massimo Claudio Fantini, Gionata Fiorino, Ambrogio Orlando, Daniela Pugliese, Fernando Rizzello, Maurizio Vecchi, Antonio Di Sabatino, on behalf of IG-IBD Tags: Alimentary Tract Source Type: research

Long-term outcome of immunomodulator use in pediatric patients with inflammatory bowel disease
In the era where new biologicals are entering the market, the place of immunomodulators in the treatment of pediatric inflammatory bowel disease (IBD) needs to be reassessed. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 19, 2019 Category: Gastroenterology Authors: Karen van Hoeve, Ilse Hoffman, Andr é D’Hoore, Marc Ferrante, Séverine Vermeire Tags: Alimentary Tract Source Type: research

Chronic atrophic gastritis: Natural history, diagnosis and therapeutic management. A position paper by the Italian Society of Hospital Gastroenterologists and Digestive Endoscopists [AIGO], the Italian Society of Digestive Endoscopy [SIED], the Italian Society of Gastroenterology [SIGE], and the Italian Society of Internal Medicine [SIMI]
Chronic atrophic gastritis (CAG) is an underdiagnosed condition characterised by translational features going beyond the strict field of gastroenterology as it may manifest itself by a variable spectrum of gastric and extra-gastric symptoms and signs. It is relatively common among older adults in different parts of the world, but large variations exist. Helicobacter pylori-related CAG [multifocal] and autoimmune CAG (corpus-restricted) are apparently two different diseases, but they display overlapping features. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 19, 2019 Category: Gastroenterology Authors: Edith Lahner, Rocco Maurizio Zagari, Angelo Zullo, Antonio Di Sabatino, Alberto Meggio, Paola Cesaro, Marco Vincenzo Lenti, Bruno Annibale, Gino Roberto Corazza Tags: Guidelines Source Type: research

Potential impact of Helicobacter pylori-related Galectin-3 on chronic kidney, cardiovascular and brain disorders in decompensated cirrhosis
Oikonomou et al. [1] concluded that Galectin-3 (Gal-3) is a novel marker of chronic kidney disease with predictive ability in decompensated cirrhosis and an index of disease outcome. Notably, although the relationship between plasma concentrations of Gal-3 and estimated glomerular filtration rate (eGFR) is well established [2], a similar association in a cohort of patients with liver cirrhosis has not been studied so far. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 17, 2019 Category: Gastroenterology Authors: Marina Boziki, Nikolaos Grigoriadis, Michael Doulberis, Apostolis Papaefthymiou, Stergios A. Polyzos, Jannis Kountouras Tags: Correspondence Source Type: research

Endoscopic submucosal dissection: Italian national survey on current practices, training and outcomes
Most of the evidence supporting endoscopic submucosal dissection (ESD) comes from Asia. European data are primarily reported by specialized referral centers and thus may not be representative of common European ESD practice. The aim of this study is to understand the current state of ESD practice across Italian endoscopy centers. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 17, 2019 Category: Gastroenterology Authors: Roberta Maselli, Federico Iacopini, Francesco Azzolini, Lucio Petruzziello, Mauro Manno, Luca De Luca, Paolo Cecinato, Giancarla Fiori, Teresa Staiano, Erik Rosa Rizzotto, Stefano Angeletti, Angelo Caruso, Franco Coppola, Gianluca Andrisani, Edi Viale, Gu Tags: Digestive Endoscopy Source Type: research

Solitary Peutz ⿿Jeghers type hamartomatous polyp in the transverse colon of an adolescent with ulcerative colitis
A seventeen-year-old male patient underwent surveillance colonoscopy 7 years after being diagnosed with ulcerative colitis. The procedure revealed a 2-cm pedunculated polyp in the transverse colon (Fig. 1A) and superficial ulcerations at the hepatic flexure. Histologic evaluation demonstrated a colonic polyp with branching smooth muscle fibers without significant increased lamina propria-to-crypt ratio, crypt dilatation, or dysplasia (Fig. 1B, H&E, ÿ40). Smooth-muscle actin immunostain highlighted the smooth muscle bands (figure C, ÿ40). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 14, 2019 Category: Gastroenterology Authors: Juan Putra, Daniel J. Mulder Tags: Image of the Month Source Type: research

Etiology of non-cirrhotic portal vein thrombosis in children: Few or many causes?
We read with interest the article ⿿Etiology, presenting features and outcome of children with non-cirrhotic portal vein thrombosis: a multicentre national study⿿ recently published in Digestive and Liver Disease [1]. In their survey, Di Giorgio et al. investigated the clinical factors possibly involved in the pathogenesis of por tal vein thrombosis (PVT) and found that history of prematurity, often extreme or very pre-term, associated neonatal illnesses and umbilical vein catheterization were the incidental risk factors, occurring in 60⿿80% of neonates. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 14, 2019 Category: Gastroenterology Authors: Massimo Primignani, Giulia Tosetti Tags: Correspondence Source Type: research

Post-reflux swallow-induced peristaltic wave index and mean nocturnal baseline impedance predict PPI response in GERD patients with extra esophageal symptoms
Mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index are able to increase the diagnostic yield of impedance-pH and are associated to proton pump inhibitor (PPI) response. Few data concerning these variables in patients with extra-esophageal symptoms (EES) are available. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 14, 2019 Category: Gastroenterology Authors: Mentore Ribolsi, Michele Pier Luca Guarino, Alessandro Tullio, Michele Cicala Tags: Alimentary Tract Source Type: research

Double pylorus
A 56-year-old male presented with progressive upper abdominal pain for 5 days at our department. He had neither undergone endoscopy nor recently used non-sterodial anti-inflammatory drugs. He underwent his first upper gastrointestinal endoscopy, showing two openings, which were separated by a bridge, between gastric antrum and duodenal bulb (Fig. 1A, upper panel). A closer endoscopic observation also demonstrated an ulcer in one of the two openings (Fig. 1A, lower panel). Thus, a diagnosis of double pylorus with an ulcer in the gastroduodenal fistula was diagnosed. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 11, 2019 Category: Gastroenterology Authors: Xingshun Qi, Xiaozhong Guo, Xiaodong Shao Tags: Image of the Month Source Type: research

L-carnitine supplementation attenuates NAFLD progression and cardiac dysfunction in a mouse model fed with methionine and choline-deficient diet
Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disorder. NAFLD, associated lipotoxicity, fibrosis, oxidative stress, and altered mitochondrial metabolism, is responsible for systemic inflammation, which contributes to organ dysfunction in extrahepatic tissues, including the heart.We investigated the ability of L-carnitine (LC) to oppose the pathogenic mechanisms underlying NAFLD progression and associated heart dysfunction, in a mouse model of methionine-choline-deficient diet (MCDD). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 10, 2019 Category: Gastroenterology Authors: Giulia Mollica, Pamela Senesi, Roberto Codella, Fernanda Vacante, Anna Montesano, Livio Luzi, Ileana Terruzzi Tags: Liver, Pancreas and Biliary Tract Source Type: research

Prevalence of colorectal cancer in cryptogenic pyogenic liver abscess patients. Do they need screening colonoscopy? A systematic review and meta-analysis
Cryptogenic pyogenic liver abscess (PLA) could result due to compromised colonic mucosal barrier in patients with colorectal cancer (CRC). Association of PLA and CRC is unclear. Evidence is weak and limited to small sized studies. As a result, the need for colonoscopy in PLA patients is debatable. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 7, 2019 Category: Gastroenterology Authors: Babu P. Mohan, Veeraraghavan Meyyur Aravamudan, Shahab R. Khan, Saurabh Chandan, Suresh Ponnada, Ravishankar Asokkumar, Udayakumar Navaneethan, Douglas G. Adler Tags: Meta-Analysis Source Type: research

Stylet slow-pull vs. standard suction technique for endoscopic ultrasound-guided fine needle biopsy in pancreatic solid lesions using 20 Gauge Procore ™ needle: A multicenter randomized trial
Standard suction and slow-pull techniques have been utilized during endoscopic ultrasound-guided fine needle aspiration of pancreatic solid lesions, but the correct sampling technique remains unclear. New needles designed to obtain samples suitable for histological evaluation have become available. We performed a study comparing the two sampling methods during endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) in patients with pancreatic solid lesions. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 7, 2019 Category: Gastroenterology Authors: Roberto Di Mitri, Filippo Mocciaro, Filippo Antonini, Daniela Scimeca, Elisabetta Conte, Ambra Bonaccorso, Nunzia Scibetta, Elettra Unti, Adele Fornelli, Sara Giorgini, Cecilia Binda, Giampiero Macarri, Alberto Larghi, Carlo Fabbri Tags: Digestive Endoscopy Source Type: research

The additive value of sarcopenia, myosteatosis and hepatic encephalopathy in the predictivity of model for end-stage liver disease
Since the use of the Model for End-Stage Liver Disease (MELD) score for establishing the prognosis of cirrhotic patients has been introduced, questions have been raised whether complications of liver cirrhosis would provide additional information. Myosteatosis, sarcopenia and hepatic encephalopathy (HE) are frequent in cirrhosis and may affect prognosis.Aim of the study was analyzing if these factors are independently related to survival and may improve the accuracy of MELD. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 7, 2019 Category: Gastroenterology Authors: Barbara Lattanzi, Silvia Nardelli, Alessandra Pigliacelli, Simone Di Cola, Alessio Farcomeni, Daria D ’Ambrosio, Stefania Gioia, Stefano Ginanni Corradini, Cristina Lucidi, Gianluca Mennini, Massimo Rossi, Manuela Merli, Oliviero Riggio Tags: Liver, Pancreas and Biliary Tract Source Type: research

Usefulness of dedicated forceps for digital single-operator cholangioscopy for the treatment of inflammatory biliary stricture
Endoscopic treatment of biliary strictures is challenging; moreover, if stenosis is almost complete, dilation can fail for inability to pass over a guidewire dilation devices or stent [1]. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 4, 2019 Category: Gastroenterology Authors: P. Soriani, S. Vavassori, S. Deiana, M. Manno Tags: Image of the Month Source Type: research

Hepatitis C remains leading indication for listings and receipt of liver transplantation for hepatocellular carcinoma
With the availability of direct acting antivirals (DAA) for hepatitis C virus (HCV) infection, alcoholic liver disease (ALD) has evolved as the leading indication for listing and receipt of liver transplantation (LT) followed by non-alcoholic steatohepatitis and HCV infection. However, data are limited on etiology specific trends on listings and need for LT for hepatocellular carcinoma (HCC). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 30, 2019 Category: Gastroenterology Authors: Ashwani K. Singal, Sanjaya K. Satapathy, Nancy Reau, Robert Wong, Yong-Fang Kuo Tags: Liver, Pancreas and Biliary Tract Source Type: research

Risk factors for locally advanced cancer associated with ulcerative colitis: Results of a retrospective multicentric study in the era of biologics
Patients affected by ulcerative colitis (UC) are more likely to develop colorectal cancer, and are often diagnosed with lymph node involvement (N+) at surgery. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 30, 2019 Category: Gastroenterology Authors: Matteo Rottoli, Marta Tanzanu, Francesca Di Candido, Francesco Colombo, Alice Frontali, Pramodh C. Chandrasinghe, Gianluca Pellino, Matteo Frasson, Janindra Warusavitarne, Yves Panis, Gianluca M. Sampietro, Antonino Spinelli, Gilberto Poggioli Tags: Alimentary Tract Source Type: research

Ureterosigmoidostomy
A 43-year-old asymptomatic female with a history of urinary diversion as a child for bladder exstrophy presented for colonoscopy. In the lower sigmoid two hyperemic polypoid nodules with central orifices, corresponding to the surgical implant sites of the ureters, were identified (Fig. 1A). Further characterization of the mucosal surface favoured chronic chemical irritation over a neoplastic pattern (Fig. 1B), which was further supported by narrow band imaging with zoom (Fig. 1C). Biopsies from the periphery confirmed presence of chronic inflammation with granulation tissue. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 30, 2019 Category: Gastroenterology Authors: Vincent Zimmer, Frank Lammert Tags: Image of the Month Source Type: research

Clinical value of asterixis in 374 well-characterised patients with cirrhosis and varying degree of hepatic encephalopathy
Current guidelines for the diagnosis of hepatic encephalopathy (HE) include the clinical sign asterixis, which defines grade II overt HE in the absence of disorientation to time [1]. Asterixis has also been used as an outcome in clinical trials [2]. However, limited information is available on the ability of physicians to detect/grade asterixis, and the relationship between asterixis and other clinical or quantitative HE indices. The aim of the present study was to retrospectively assess the clinical value of asterixis in a large population of well-characterised patients with varying degree of HE. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 30, 2019 Category: Gastroenterology Authors: Chiara Formentin, Lisa Zarantonello, Chiara Mangini, Paolo Angeli, Carlo Merkel, Sara Montagnese Tags: Correspondence Source Type: research

Editorial Board
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 25, 2019 Category: Gastroenterology Source Type: research

Muscle psoas indices measured by ultrasound in cirrhosis — Preliminary evaluation of sarcopenia assessment and prediction of liver decompensation and mortality
No data on the European population exists regarding the use of an ultrasoundbased measurement of psoas diameter for sarcopenia assessment in cirrhosis. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 20, 2019 Category: Gastroenterology Authors: Andrej Hari, Annalisa Berzigotti, Borut Štabuc, Nina Caglevič Tags: Liver, Pancreas and Biliary Tract Source Type: research

Colorectal polyp prevalence and aspirational detection targets determined using high definition colonoscopy and a high level detector in 2017
We describe the prevalence of colorectal adenomas determined by a single high detecting colonoscopist using high definition colonoscopes. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 20, 2019 Category: Gastroenterology Authors: Douglas K. Rex, Andrew W. Sullivan, Anthony J. Perkins, Krishna C. Vemulapalli Tags: Digestive Endoscopy Source Type: research

Combination and sequential evaluation of acute-on-chronic liver failure (ACLF) and hyponatremia and prognosis in cirrhotic patients
Few studies have evaluated whether combination and sequential evaluation of ACLF (acute-on-chronic liver failure) and hyponatremia aids prognosis. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 18, 2019 Category: Gastroenterology Authors: Gustavo Pereira, Caroline Baldin, Juliana Piedade, Vanessa Reis, Tatiana Valdeolivas, L ívia Victor, Lívia Guimarães, Joana Duarte, Zulane Veiga, Camila Alcântara, Flávia Fernandes, João Luiz Pereira Tags: Liver, Pancreas and Biliary Tract Source Type: research

Thymosin β4 alleviates cholestatic liver fibrosis in mice through downregulating PDGF/PDGFR and TGFβ/Smad pathways
In this study, effects of thymosin β4 (Tβ4) on hepatic fibrogenesis and the underlying molecular mechanisms were explored in bile duct ligation (BDL)-induced mice cholestatic liver fibrosis model. Results showed exogenous Tβ4 significantly reduced the mortality and liver/body weight ratio in BDL mice. Histological examinations and biochemical analyses demonstrated that BDL induced evident portal fibrosis and a significant increase in hepatic collagen contents. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 18, 2019 Category: Gastroenterology Authors: Cai Chen, Xiankui Li, Lei Wang Source Type: research

Muscle abnormalities in cirrhosis: Calling for more strength in evaluation and prevention
Gira el mon i torna al Born*. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 18, 2019 Category: Gastroenterology Authors: Chiara Becchetti, Jaume Bosch Tags: Editorial Source Type: research

New reports of curcumine-induced hepatitis
Curcuma is an herbaceous plant of the Zingiberaceae family; it's widely used in the south eastern cuisine. And as a spice in the Indian cuisine as well. Curcuma is also known as the Saffron of Indies. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 16, 2019 Category: Gastroenterology Authors: G. Gasbarrini, C. Mosoni, F. Bonvicini Tags: P-01 Source Type: research

Social and labor market reintegration of the transplanted patient
Introduction: The number of working-age patients with organ failure undergoing solid organ transplantation is presently increasing, posing important problems with reintegration in society and the workplace. The Project “Development of a multidisciplinary network and Web Applications to encourage the adoption of healthy lifestyle, overcoming psychological barriers and encourage the return-to-work of transplanted patients” aims to provide tools that facilitate the psychophysical recovery and return-to-work of tr ansplanted patients, through the prescription of physical activity as non-pharmacological therapy. (So...
Source: Digestive and Liver Disease - September 16, 2019 Category: Gastroenterology Authors: L. Bellis, C. Carella, M. Trerotola, L. Lombardini, E. Sorrentino, R. Melloni, G. Mosconi, G. Sella, S. Mosconi, G. Sangiorgi, C. De Cillia, V. Totti, M.C. Morelli, V. Vero, A. Ermolao, C. Canali, B. Papaleo, A. Nanni Costa, M. Cardillo Tags: P-02 Source Type: research

The ITA.LI.CA network: description and results of its activity
Introduction: The incidence of hepatocellular carcinoma (HCC) is increasing in most Western countries, being one of the main causes of oncological mortality. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 16, 2019 Category: Gastroenterology Authors: F. Avanzato, F. Garuti, A. Neri, A. Gramenzi, V. Santi, F. Morisco, F. Trevisani, for the Italian Liver Cancer (ITA.LI.CA) group Tags: P-03 Source Type: research

Effect of alpha-fetoprotein on survival in HIV-infected patients with hepatocellular carcinoma
Aim: The aim of the study was to investigate the association between alpha-fetoprotein (AFP) levels and HCC prognosis among people living with HIV (PLWH). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 16, 2019 Category: Gastroenterology Authors: E. Messina, L. Galli, G. Morsica, H. Hasson, S. Bagaglio, S. Salpietro, S. Bhoori, V. Mazzaferro, A. Lazzarin, A. Castagna, C. Uberti Foppa Tags: P-04 Source Type: research

How does Trieste treat HCV in PWID? An effective coordination between addiction treatment service (SerD), the infective disease department and the liver clinic
According to Italian data, people who inject drugs (PWID) have high prevalence of Hepatitis C Virus (HCV) infection (30-60%). PWID have inadequate access to directly acting antivirals (DAA) due to (1) their mistrust towards the healthcare system and (2) the lack of coordination between medical specialists who play a pivotal role in the diagnosis and treatment of HCV infection. We aim to describe the HCV -treatment cascade of care in Trieste on PWID. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 16, 2019 Category: Gastroenterology Authors: F. Masutti, M. Giuffr è, M. Santi, M.I. Crosato, R. Luzzati, R. Balestra, L.S. Crocè Tags: P-05 Source Type: research

Resources optimization in DAA-based HCV treatment through a simplified on-treatment schedule
Introduction: From May 2017, AIFA has allowed to treat low-fibrotic HCVRNA(+)pts with DAA. In order to maintain an unmodified access to cure, a different and simplified treatment scheduled had to be implemented. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 16, 2019 Category: Gastroenterology Authors: L. Pasulo, M. Colpani, C. Iegri, M. Degiorgio, S. Regazzoni, L. Rota, S. Gritti, S. Fagiuoli Tags: P-06 Source Type: research

Current epidemiology of HCV in Sicily: the RESIST-HCV model
Background: Real-world data to guide hepatitis C virus (HCV)-related public health initiatives and linkage to care of patients are lacking in our region. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 16, 2019 Category: Gastroenterology Authors: V. Di Marco, F. Cartabellotta, W. Mazzucco, V. Calvaruso, S. Petta, S. Mazzola, R. Cusimano, R. Amodio, G. Scifo, M. Russello, B. Cacopardo, G. Squadrito, G. Raimondo, T. Pollicino, F. Ceccherini-Silbertein, F. Vitale, C. Camm à, A. Craxì, on behalf of Tags: P-07 Source Type: research

Second-generation DAAs for HCV: real-life efficacy in the RESIST-HCV cohort
Background and aims: RESIST-HCV (Rete Sicilia Selezione Terapia – HCV) registers all patients in Sicily with chronic HCV infection treated with DAAs, allowing a real-time measure of their efficacy in practice. This analysis aims to evaluate second-generation regimens (Sofosbuvir plus Velpatasvir: SOF/VEL; Glecaprevir plus Pibrentasvir: GLE/PIB;Elbasvir/Grazopr evir: EBV/GRZ), in order to evaluate SVR rates of DAA-naïve patients to currently available regimens. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 16, 2019 Category: Gastroenterology Authors: I. Cacciola, S. Petta, V. Calvaruso, F. Cartabellotta, M. Distefano, G. Scifo, F. Di Lorenzo, A. Sanfilippo, M.A. Di Rosolini, A. Dav ì, F. Benanti, B. Cacopardo, A. Licata, L. Giannitrapani, M.R. Cannavò, M. Russello, S. Madonia, M.G. Bavetta, A. Digia Tags: P-08 Source Type: research

Screening and linkage to care of prisoners with HCV infection: the RESIST-HCV project
Background: In prisons there are high prevalence of hepatitis C virus (HCV) infection, high rate of PWID and a substantial risk of HCV transmission. Epidemiological studies are needed to evaluate the rate of prisoners with chronic HCV hepatitis and to establish how many of them need Direct Acting Antiviral (DAA) therapy. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 16, 2019 Category: Gastroenterology Authors: T. Prestileo, F. Scalici, R. Insinna, L. Di Marco, M. Rossi, C. Celsa, M. Licata, S. Marchese, A. Di Lorenzo, M. Milesi, G. Rizzo, A. Busacca, F. Cartabellota, V. Di Marco, on behalf of RESIST-HCV (Rete Sicilia Selezione Terapia - HCV) Tags: P-09 Source Type: research

MetaLiverCat: the NAFLD/NASH multidisciplinary board at Fondazione Policlinico Gemelli IRCCS
Introduction: The development of patient journey for patients with Nonalcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is a current challenge for outpatient liver centers. The early identification of high-risk patients with NAFLD/NASH require multidisciplinary approach in order to assure the appropriate specialistic referral in a personalized model of chronic care program. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 16, 2019 Category: Gastroenterology Authors: L. Miele, F.R. Ponziani, A. Liguori, A. Nicoletti, F. Fianchi, A. Nesci, F. De Leva, M.G. Marini, B. Aquilanti, G. Matera, S. Della Casa, A. De Magistris, L. Gagliardi, G. Marrone, M. Biolato, F. Pizzolante, N. De Matthaeis, L. Salvatore, C. Guidone, M.A. Tags: P-10 Source Type: research

Editorial Board
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 16, 2019 Category: Gastroenterology Source Type: research

Why do guidelines supersede the conference consensus?
For 20  years, all French academic cooperative groups of physicians involved in fighting digestive cancers have designed and shared recommendations, which are widely diffused in francophone countries and contribute to a high level of care. The French National guidelines are available free online in Frenc h (www.tncd.org), however they were recently published in part in English [1–6] and are regularly updated. They are the result of a consensus between gastroenterologists, oncologists, surgeons, radiologists, radiotherapists, pharmacists, nuclear medicine specialists and pathologists. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 16, 2019 Category: Gastroenterology Authors: J.M. Phelip, O. Bouche, T. Aparicio, C. Lepage Tags: Editorial Source Type: research

Long non-coding RNA GAS5 inhibits migration and invasion in gastric cancer via interacting with p53 protein
The rapid progress of gastric cancer (GC) is mainly due to metastasis. Long non-coding RNA (lncRNA) GAS5 has been identified as a tumor suppressor in numerous cancers, and its downregulation in GC has already been reported. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 14, 2019 Category: Gastroenterology Authors: Yongchao Liu, Lu Yin, Chunqiu Chen, Xiangyu Zhang, Sheng Wang Tags: Oncology Source Type: research

Esophageal pH-impedance monitoring in children: position paper on indications, methodology and interpretation by the SIGENP working group
Multichannel intraluminal impedance pH (MII-pH) monitoring currently represents the gold standard diagnostic technique for the detection of gastro-esophageal reflux (GER), since it allows to quantify and characterize all reflux events and their possible relation with symptoms. Over the last ten years, thanks to its strengths and along with the publication of several clinical studies, its worldwide use has gradually increased, particularly in infants and children. Nevertheless, factors such as the limited pediatric reference values and limited therapeutic options still weaken its current clinical impact. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 13, 2019 Category: Gastroenterology Authors: Paolo Quitadamo, Renato Tambucci, Valentina Mancini, Fernanda Cristofori, Mariella Baldassarre, Licia Pensabene, Ruggiero Francavilla, Giovanni Di Nardo, Tamara Caldaro, Paolo Rossi, Saverio Mallardo, Elena Maggiora, Annamaria Staiano, Francesco Cresi, Si Tags: Position Paper Source Type: research

Chromoendoscopy or white light endoscopy for neoplasia detection in Lynch syndrome, a meta-analysis
This study aimed to compare the diagnostic yields of image enhancement modalities for colorectal neoplasia in patients with Lynch syndrome. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 13, 2019 Category: Gastroenterology Authors: Ofir Har-Noy, Diana E. Yung, Anastasios Koulaouzidis, Rami Eliakim, Uri Kopylov, Benjamin Avidan, Lior H. Katz Tags: Meta-Analysis Source Type: research

High prevalence of early atherosclerotic and cardiac damage in patients undergoing liver transplantation: Preliminary results
Liver transplanted patients are at high risk of metabolic syndrome and its complications. We aimed to prospectively evaluate the early onset of cardiovascular alterations in patients submitted to the transplant waiting list. From January 2014 to January 2016, 54 out of 79 patients on the waiting list with decompensated cirrhosis or hepatocellular-carcinoma received the transplant, 50 were followed for 24 months, 2 died post-surgery and 2 were lost to follow-up. A significantly increased prevalence of visceral adiposity (epicardial adipose tissue thickness (p  = 0.001) and worsening of carotid damage (p = 0.003) and...
Source: Digestive and Liver Disease - September 11, 2019 Category: Gastroenterology Authors: Giuseppina Pisano, Maria Francesca Donato, Dario Consonni, Giovanna Oberti, Vittorio Borroni, Rosa Lombardi, Federica Invernizzi, Cristina Bertelli, Lucio Caccamo, Marianna Porzio, Daniele Dondossola, Giorgio Rossi, Silvia Fargion, Anna Ludovica Fracanzan Tags: Liver, Pancreas and Biliary Tract Source Type: research

Pseudomyxoma peritonei of the appendix after ileocecal resection: Expect the unexpected
A 32-year-old female patient with Crohn ’s disease presented with vomiting, diarrhea, night sweating and pain in the lower right abdomen for over three months. She underwent an ileocecal resection ten years earlier and her Crohn’s disease remained in remission without medication ever since. Initially, it was assumed that patient had a flare-up of the Crohn’s disease. A computed tomography (CT) showed quiescent Crohn’s disease, ascites and a cystic mass adjacent to the ascending colon without involvement of the right ovary (Fig. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 7, 2019 Category: Gastroenterology Authors: Melek Simsek, Annemiek J. Linn, Nanne K.H. de Boer Tags: Image of the Month Source Type: research

Splenic serum from portal hypertensive patients enhances liver stem cell proliferation and self-renewal via the IGF-II/ERK signaling pathway
Hypersplenism is a serious complication of portal hypertension (PH) and can affect the prognosis of liver disease. Liver stem cells (LSCs) are involved in liver regeneration and hepatocarcinogenesis after liver cirrhosis. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 5, 2019 Category: Gastroenterology Authors: Jiangwei Li, Ren Li, Wei Jiang, Jin Sun, Jun Li, Ying Guo, Kai Zhu, Chen Zhang, Guangyao Kong, Zongfang Li Tags: Liver, Pancreas and Biliary Tract Source Type: research

SET nuclear proto-oncogene gene expression is associated with microsatellite instability in human colorectal cancer identified by co-expression analysis
Microsatellite instability (MSI) is one of the promising biomarkers in human colorectal cancers (CRCs), and it is influenced by an intricate gene interaction network. Hence, we aimed to identify and validate hub genes associated with MSI CRC and to illustrate its underlying mechanisms. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 5, 2019 Category: Gastroenterology Authors: Haizhou Wang, Peishan Qiu, Shuyun Zhu, Mengna Zhang, Yizhang Li, Meng Zhang, Xiaobing Wang, Jian Shang, Bing Qu, Jing Liu, Qiu Zhao Tags: Oncology Source Type: research

Agreement and compliance with process measures proposed by the AASLD Practice Metrics Committee: An Italian perspective
In a recent study [1], the Practice Metrics Committee of the American Association for the Study of Liver Diseases (AASLD) proposed a set of evidence-based quality measures for adult patients with cirrhosis, to be used for care quality evaluation. The system encompasses 26 process measures, 7 clinical outcome measures, and 13 patient-reported outcome measures and, as the authors indicate in the discussion, is not yet ready for application. In order to evaluate how it would be perceived by liver specialists in a different country, the Italian Association for the Study of the Liver (AISF) translated the 26 process measures st...
Source: Digestive and Liver Disease - August 29, 2019 Category: Gastroenterology Authors: Sara Montagnese, on behalf of AISF, the Italian Association for the Study of the Liver Tags: Correspondence Source Type: research

Extensive vascular embolism after endoscopic variceal obliteration
A 53-year-old male with a history of alcoholic liver cirrhosis presented with hematemesis. Emergency endoscopic examination revealed a huge gastric varix with stigmata at the fundus. Hemostasis was achieved through endoscopic variceal obliteration using a mixture of N-butyl-2-cyanoacrylate (1cc) and lipiodol (1cc) injection three times for hemostasis at a single session. Post-procedural X-ray revealed radiopaque materials. Sequential computed tomography of the abdomen revealed acute obstruction of the portal system with the injected mixture (Fig. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 24, 2019 Category: Gastroenterology Authors: Seong-Jung Kim, Ju-Yeon Cho Tags: Image of the Month Source Type: research

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Source: Digestive and Liver Disease - August 21, 2019 Category: Gastroenterology Source Type: research

Sodium load and intravenous antimicrobials in patients with cirrhosis
Strong evidence indicates that reduction of salt intake lowers blood pressure and reduces the risk of cardiovascular disease and all-cause mortality [1]. This issue has also been deeply investigated in patients with decompensated cirrhosis. In fact, the guidelines of the European Association for the Study of the Liver (EASL) recommend a salt intake of 4.6-6.9 g/daily, corresponding to 1.84-2.76 g of sodium/daily, for patients with cirrhosis and ascites.[2] In the advanced stage of cirrhosis, splanchnic vasodilation causes a marked arterial underfilling that induces the maximum activation of the renin-angiotensin-aldosteron...
Source: Digestive and Liver Disease - August 20, 2019 Category: Gastroenterology Authors: S. Maimone, A.T. Mazzeo, G. Squadrito, G. Raimondo Tags: Correspondence Source Type: research

Evaluation of the prognostic impact of pathologic response to preoperative chemotherapy using Mandard ’s Tumor Regression Grade (TRG) in gastric adenocarcinoma
Perioperative chemotherapy is the gold standard in gastric cancer management. The prognostic significance of pathological response has been investigated in many malignancies, using Tumor Regression Grade (TRG). Its prognostic value in gastric cancer remains poorly known. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 16, 2019 Category: Gastroenterology Authors: Simon Derieux, Magali Svrcek, Sarah Manela, Christine Lagorce-Pages, Anne Berger, Thierry Andr é, Julien Taieb, François Paye, Thibault Voron Tags: Original article Source Type: research