ABCB4-alteration screening in adult-onset cholestasis
Over the last decade, modern genetic studies have provided major insights into the pathophysiology of chronic biliary diseases. Novel computational methods such as genome-wide association studies (GWAS), next-generation sequencing (NGS), and whole-genome sequencing (WGS) have played an important role in identifying possible connections between single nucleotide polymorphisms (SNPs) and various biliary and liver disorders [1]. However, these methods have not assigned specific genetic variants to the corresponding clinical phenotypes. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 15, 2021 Category: Gastroenterology Authors: Marco Carbone, Vincenzo Cardinale Tags: Editorial Source Type: research

Successful coping with SARS-CoV-2 infection of adult celiac patients assessed by telemedicine
Since December 2019, a severe acute respiratory syndrome-coronavirus-2 (SARS-CoV2) has spread worldwide from China. In March 2020 the World Health Organization has declared the pandemic. Globally, the number of reported confirmed cases exceeded 81.9 million at this time [1]. Western Countries have been severely affected by COVID-19. Since the beginning of the epidemic, Italy represents one of the most affected European countries with more than 2.1 million cases [1]. SARS-CoV-2 pandemic is having a drastic impact on routine healthcare of most hospital units that are obviously focused on the SARS-CoV-2 emergency. (Source: Di...
Source: Digestive and Liver Disease - January 14, 2021 Category: Gastroenterology Authors: Gloria Galli, Gianluca Esposito, Emanuele Dilaghi, Bruno Annibale, Edith Lahner, Laura Conti Tags: Correspondence Source Type: research

c-Myc affects hedgehog pathway via KCNQ1OT1/RAC1: A new mechanism for regulating HSC proliferation and epithelial-mesenchymal transition
This study aimed to probe into the potential mechanism of KCNQ1OT1 in liver fibrosis. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 12, 2021 Category: Gastroenterology Authors: Yilei Deng, Jian Li, Menghao Zhou, Zhiwei Liang, Longshuan Zhao Tags: Liver, Pancreas and Biliary Tract Source Type: research

Cytomegalovirus gastritis: Clinicopathological profile
Cytomegalovirus (CMV) gastritis is occasionally reported in case reports and limited case series. Up to now, it is the largest and most comprehensive retrospective study of CMV gastritis. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 11, 2021 Category: Gastroenterology Authors: Pai-Jui Yeh, Cheng-Tang Chiu, Ming-Wei Lai, Ren-Chin Wu, Chia-Jung Kuo, Jun-Te Hsu, Ming-Yao Su, Puo-Hsien Le Tags: Alimentary Tract Source Type: research

Hyperkalemia influences the outcome of patients with cirrhosis with acute decompensation (AD) and acute-on-chronic liver failure (ACLF)
The presence of hyperkalemia in different clinical scenarios has been described as a risk factor for mortality. Information about this electrolyte disorder in patients with cirrhosis is limited and there are no data in patients with acute-on-chronic liver failure (ACLF). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 11, 2021 Category: Gastroenterology Authors: Gabriel Mezzano, Andr és Cárdenas, Ferrán Aguilar, Marco Pavesi, Cristina Solé, Laura Napoleone, Isabel Graupera, Adrià Juanola, Marta Carol, Elisa Pose, Nuria Fabrellas, Ruben Hernaez, Javier Martínez, Faouzi Saliba, Vicente Arroyo, Elsa Sola, Pere Tags: Liver, Pancreas and Biliary Tract Source Type: research

Low sodium to potassium ratio in spot urine sample is associated with progression to acute kidney injury and mortality in hospitalized patients with cirrhosis
sodium to potassium ratio in spot urine sample (Na/Kur) is a surrogate marker of sodium excretion that is recommended for the management of patients with ascites due to cirrhosis. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 11, 2021 Category: Gastroenterology Authors: Elayne Cristina Morais Rateke, Camila Matiollo, Emerita Quintina de Andrade Moura, Michelle Andrigueti, Claudia Maccali, Jana ína Sant'Ana Fonseca, Sabine Machado Fiorenza Canova, Janaína Luz Narciso-Schiavon, Leonardo Lucca Schiavon Tags: Liver, Pancreas and Biliary Tract Source Type: research

Clinical characteristics of metabolic associated fatty liver disease (MAFLD) in subjects with myotonic dystrophy type 1 (DM1)
Myotonic dystrophy type 1 (DM1) is a rare inherited neuromuscular disease associated with insulin resistance, and its association with metabolically associated fatty liver disease (MAFLD) has never been explored in prospective studies. The aim of this study was to assess the clinical features of MAFLD in DM1 patients. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 9, 2021 Category: Gastroenterology Authors: Luca Miele, Alessia Perna, Marianxhela Dajko, Maria A. Zocco, Antonio De Magistris, Tommaso F. Nicoletti, Marco Biolato, Giuseppe Marrone, Antonio Liguori, Daria Maccora, Venanzio Valenza, Salvatore Rossi, Vittorio Riso, Daniele Di Natale, Antonio Gasbarr Tags: Liver, Pancreas and Biliary Tract Source Type: research

Editorial Board
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 8, 2021 Category: Gastroenterology Source Type: research

Acute kidney injury is associated with increased levels of circulating microvesicles in patients with decompensated cirrhosis
Microvesicles (MVs) play a role in inflammation, coagulation, and vascular homeostasis in liver disease. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 8, 2021 Category: Gastroenterology Authors: Elena Campello, Alberto Zanetto, Claudia M. Radu, Cristiana Bulato, Addolorata Truma, Luca Spiezia, Marco Senzolo, Guadalupe Garcia-Tsao, Paolo Simioni Tags: Liver, Pancreas and Biliary Tract Source Type: research

Impact of the COVID-19 outbreak and the serum prevalence of SARS-CoV-2 antibodies in patients with inflammatory bowel disease treated with biologic drugs
This study investigated the impact of the SARS-CoV-2 infection and the serum prevalence of SARS-CoV-2 antibodies in patients with inflammatory bowel disease (IBD) treated with biologic drugs. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 5, 2021 Category: Gastroenterology Authors: Fabrizio Bossa, Sonia Carparelli, Anna Latiano, Orazio Palmieri, Francesca Tavano, Anna Panza, Maria Pastore, Antonio Marseglia, Mario D'Altilia, Tiziana Latiano, Giuseppe Corritore, Giuseppina Martino, Marianna Nardella, Maria Guerra, Fulvia Terracciano, Tags: Alimentary Tract Source Type: research

Congenital intrahepatic portosystemic shunt with invasive hepatocellular carcinoma
A 60-year-old man with a history of congenital intrahepatic portosystemic shunt (CIPS) presented with acute bilateral lower-extremity edema. There were no stigmata of chronic liver disease. However, mildly abnormal liver function tests and α-fetoprotein 79.1 ng/mL were noted. Subsequent imaging revealed a 8 cm right lobe liver mass, extending into the right hepatic vein into the IVC and right atrium (A,B). An 8 mm side-to-side intrahepatic shunt between the right portal vein and the IVC (C,D – CT; E - US) was confirmed. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 4, 2021 Category: Gastroenterology Authors: Peng-Xu Ding, Chao Liu, Xin-Wei Han, Edward Wolfgang Lee Tags: Image of the Month Source Type: research

High-dose pre-endoscopic intravenous proton pump inhibitors in upper gastrointestinal bleeding: Utility or futility?
We read with interest the article by Marmo and colleagues “Pre-endoscopic intravenous proton pump inhibitors therapy for upper gastrointestinal bleeding: a prospective, multicentre study” [1] and wish to make comments. The study, which enrolled a large number of patients [2,566 overall, 1,792 (69.8%) treated with pre-endoscopic proton pump inhibitors ( PPI)] failed to detect a significant role of such therapy in decreasing prevalence of high-risk stigmata (HRS) and need for endoscopic treatment. The issue is debated. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 4, 2021 Category: Gastroenterology Authors: Massimo Primignani, Giulia Tosetti Tags: Correspondence Source Type: research

Size and location of spontaneous portosystemic shunts predict the risk of decompensation in cirrhotic patients
The prognostic role of spontaneous portosystemic shunts (SPSS) has been poorly investigated. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - January 4, 2021 Category: Gastroenterology Authors: Elton Dajti, Matteo Renzulli, Antonio Colecchia, Maria Letizia Bacchi-Reggiani, Matteo Milandri, Benedetta Rossini, Federico Ravaioli, Giovanni Marasco, Luigina Vanessa Alemanni, Anna Maria Ierardi, Gianpaolo Carrafiello, Massimo Pinzani, Francesco Azzaro Tags: Liver, Pancreas and Biliary Tract Source Type: research

Effect of water exchange method on adenoma miss rate of patients undergoing selective polypectomy: A randomized controlled trial
Adenomas may be missed in up to 40% of screening colonoscopies. Although the water exchange (WE) method can improve ADR, as shown in several RCTs, it remains uncertain whether it can increase the detection of missing adenomas compared with standard air-insufflated (AI) colonoscopy. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 31, 2020 Category: Gastroenterology Authors: Gui Ren, Xiangping Wang, Hui Luo, Shaowei Yao, Shuhui Liang, Linhui Zhang, Tao Dong, Long Chen, Qin Tao, Xuegang Guo, Ying Han, Yanglin Pan Tags: Digestive Endoscopy Source Type: research

ABCB4 variants in adult patients with cholestatic disease are frequent and underdiagnosed
Heterozygous ABCB4 variants are not routinely tested in adults with cholestasis because of their supposed rarity and high costs. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 31, 2020 Category: Gastroenterology Authors: Antonella Avena, Sandro Puggelli, Michael Morris, Andreas Cerny, Alfredo Rep áraz Andrade, Emmanuela Pareti, Florian Bihl, Daniele Cassatella, Isabelle Moix, Elisabetta Merlo, Anne-Laure Rougemont, Pietro Majno-Hurst, Diego Vergani, Giorgina Mieli-Vergan Tags: Liver, Pancreas and Biliary Tract Source Type: research

Elective home replacement of gastrostomy feeding tubes is safe and cost-effective. Has hospital referral become obsolete?
Percutaneous endoscopic gastrostomy (PEG) is the technique of choice for providing enteral nutrition in patients with functioning gastrointestinal tract. Available guidelines cover indications and procedural management for PEG placement, while there is no consensus about subsequent replacement with gastrostomy feeding tubes (GFT) and their management. We hypothesized that GFT replacement, according to a standardized protocol supervised by a trained gastroenterologist could be integrated into the home health care system. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 28, 2020 Category: Gastroenterology Authors: Anna Cominardi, Andrea Lisotti, Elena Teci, Giovanni Mangano, Pietro Fusaroli Tags: Digestive Endoscopy Source Type: research

Risk factors for recurrent primary biliary cirrhosis after liver transplantation: A systematic review and meta-analysis
Recurrent primary biliary cirrhosis (PBC) is frequently observed in patients with PBC after liver transplantation (LT). We performed a meta-analysis to evaluate the risk factors for PBC recurrence. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 28, 2020 Category: Gastroenterology Authors: Xiaocheng Li, Jing Peng, Renbin Ouyang, Yaowei Yang, Chengdong Yu, Huapeng Lin Tags: Meta-Analysis Source Type: research

Maternal anti-tumour necrosis factor- α drug use during pregnancy and risk of infection in the offspring: A systematic review and meta-analysis
Anti-tumour necrosis factor (TNF)- α drugs are used by increasing numbers of reproductive-age women. Although the neonatal outcomes have been described, there are concerns regarding the risk of infection in offspring following exposure to anti-TNF-α. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 26, 2020 Category: Gastroenterology Authors: Ting-yun Ye, Yu Mei, Dan-ni Bao, Yang-fan Zhu, Xiao-hong Xu, Li-fei Zhu Tags: Alimentary Tract Source Type: research

Obstructive rectosigmoid colon solitary extramedullary plasmacytoma
82-year-old man presented with rectal bleeding. CT abdomen-pelvis revealed obstructive mass lesion at the recto-sigmoid junction (Fig. 1A). Endoscopy revealed submucosal obstructing mass within the rectosigmoid colon at approximately 18  cm proximal to the anus (Fig. 1B). Endoscopic ultrasound (Fig. 1C) demonstrated a large hypoechoic mass lesion with biopsy proven plasma cell neoplasm. Staging F18-FDG PET/CT revealed a solitary hypermetabolic rectosigmoid mass (Fig. 1D& E). Based on imaging and biopsy, following systemic work-up, a diagnosis of a solitary extramedullary plasmacytoma was achieved. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 26, 2020 Category: Gastroenterology Authors: Ronik S. Bhangoo, Ann E. McCullough, Ming Yang Tags: Image of the Month Source Type: research

COVID-19 in IBD: the experience of a single tertiary IBD center
Italy has been one of the most affected countries in the world by COVID-19. There has been increasing concern regarding the impact of COVID ‐19 on patients with inflammatory bowel disease (IBD), particularly in patients treated with immunosuppressants or biologics. The aim of our study is to understand the incidence of COVID-19 in a large cohort of patients with IBD. Furthermore, we analyzed possible risk factors for infection and sev erity of COVID-19. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 26, 2020 Category: Gastroenterology Authors: Prof Fernando Rizzello, Carlo Calabrese, Marco Salice, Lucia Calandrini, Hana Privitera, Laura Melotti, Giulia Peruzzi, Nikolas Dussias, Andrea Belluzzi, Eleonora Scaioli, Anastasio Decorato, Antonio Siniscalchi, Eleonora Filippone, Prof Silvio Laureti, M Source Type: research

Editorial Board
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 25, 2020 Category: Gastroenterology Source Type: research

Avelumab versus standard second line treatment chemotherapy in metastatic colorectal cancer patients with microsatellite instability: The SAMCO-PRODIGE 54 randomised phase II trial
Immune checkpoint inhibitors have failed in treating metastatic colorectal cancer (mCRC) patients except those with dMMR/MSI tumors. However, until very recently we had only non-comparative promising data in this population with anti-programmed cell death 1/ programmed cell death ligand 1 (PD1/PD-L1) antibodies alone or combined with anti- cytotoxic T-lymphocyte-associated protein 4 (CTLA4) antibodies.This comparative phase II trial (NCT 03186326), conducted in more than 100 centers in France, will include dMMR/MSI mCRC patients with progression after a first-line treatment with chemotherapy ± targeted therapies, to...
Source: Digestive and Liver Disease - December 25, 2020 Category: Gastroenterology Authors: Julien Ta ïeb, Thierry André, Farid El Hajbi, Emilie Barbier, Clémence Toullec, Stefano Kim, Olivier Bouche, Frederic Di Fiore, Marion Chauvenet, Hervé Perrier, Ludovic Evesque, Pierre Laurent-Puig, Jean-François Emile, Jérémie Bez, Côme Lepage, D Tags: Progress report Source Type: research

Impact of COVID-19 pandemic on the management of paediatric inflammatory bowel disease: An Italian multicentre study on behalf of the SIGENP IBD Group
IBD management has been significantly affected during the COVID-19 lockdown with potential clinical issues. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 25, 2020 Category: Gastroenterology Authors: Serena Arrigo, Patrizia Alvisi, Claudia Banzato, Matteo Bramuzzo, Rosaria Celano, Fortunata Civitelli, Giulia D'Arcangelo, Anna Di Lillo, Valeria Dipasquale, Enrico Felici, Maurizio Fuoti, Simona Gatti, Daniela Knafelz, Paolo Lionetti, Federica Mario, Ant Tags: Alimentary Tract Source Type: research

Risk of COVID 19 in patients with inflammatory bowel diseases compared to a control population
It is unclear whether patients with inflammatory bowel disease (IBD) are at increased risk of COVID-19. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 25, 2020 Category: Gastroenterology Authors: Giovanni Maconi, Cristina Bosetti, Alberta De Monti, Ray Kiran Boyapati, Edward Shelton, Nicole Piazza, Anna Maria Carvalhas Gabrielli, Marco Vincenzo Lenti, Cristina Bezzio, Chiara Ricci, Salvatore Greco, Samanta Romeo, Francesco Giangregorio, Daniele Gr Tags: Alimentary Tract Source Type: research

PRODIGE 59-DURIGAST trial: A randomised phase II study evaluating FOLFIRI  + Durvalumab ± Tremelimumab in second-line of patients with advanced gastric cancer
Gastric or gastro-oesophageal junction (GEJ) adenocarcinomas present poor overall survival (OS). First-line chemotherapy regimen for patients with HER2-negative tumours is based on a doublet or triplet of fluoropyrimidine plus platinum salt ± taxane. Second-line chemotherapy (Docetaxel or Irinotecan) improves OS which nonetheless remains poor (around 5 months). The first results of immune checkpoint inhibitors (anti-PD-1) combined with chemotherapy in metastatic gastric and GEJ cancers were discordant in recent phase III trials. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 21, 2020 Category: Gastroenterology Authors: Camille Evrard, Christophe Louvet, Farid EL Hajbi, Fr édéric DI Fiore, Karine LE Malicot, Thomas Aparicio, Olivier Bouché, Pierre Laurent-Puig, Frédéric Bibeau, Thierry Lecomte, Astrid Lièvre, Rosine Guimbaud, Stefano Kim, Aziz Zaanan, Harry Sokol, Tags: Progress Report Source Type: research

Low-frequency of RABL3 pathogenetic variants in hereditary and familial pancreatic cancer
Pancreatic carcinoma (PC) can be inherited as hereditary and familial pancreatic cancer (HPC and FPC). HPC is a genetically confirmed PC, accounting for 10 –15% of PC. FPC is diagnosed when three relatives have PC, or when two relatives are affected with one first degree relative (FDR): 5–10% of all PCs fit these criteria [1-4]. Autosomal dominant transmission of inheritance for HPC is identified in genes causing hereditary pancreatitis (PRSS1 gene ), hereditary breast and ovarian cancer (BRCA1 and BRCA2 genes), familial atypical multiple mole melanoma (FAMMM) with p16 gene (CDKN2a) germline mutation, Lynch syn...
Source: Digestive and Liver Disease - December 19, 2020 Category: Gastroenterology Authors: Marta Puzzono, Stefano Crippa, Raffaella Alessia Zuppardo, Ettore Zapparoli, Massimo Falconi, Giulia Martina Cavestro Tags: Correspondence Source Type: research

Early ultrasound guided percutaneous liver biopsy in former preterm infants
We aim to debate the topic of early ultrasound guided percutaneous liver biopsy (US-PLB) in former preterm infants. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 19, 2020 Category: Gastroenterology Authors: Alessandra Preziosi, Morandi Anna, Ferrari Carlo, Nebbia Gabriella, Leva Ernesto, Francesco Macchini Tags: Correspondence Source Type: research

Comparison of prognostic models in advanced hepatocellular carcinoma patients undergoing Sorafenib: A multicenter study.
Sorafenib is the gold standard therapy for the advanced hepatocellular carcinoma (HCC). No scoring/staging is universally accepted to predict the survival of these patients. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 19, 2020 Category: Gastroenterology Authors: Giovanni Marasco, Antonio Colecchia, Maria Letizia Bacchi Reggiani, Ciro Celsa, Fabio Farinati, Edoardo Giovanni Giannini, Francesca Benevento, Gian Ludovico Rapaccini, Eugenio Caturelli, Mariella Di Marco, Elisabetta Biasini, Fabio Marra, Filomena Morisc Tags: Liver, pancreas and biliary tract Source Type: research

Spontaneous portosystemic shunts in cirrhosis: Detection, implications, and clinical associations
Spontaneous portosystemic shunts (SPSS) are common in cirrhosis. Their characterization and clinical implications remain unclear. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 16, 2020 Category: Gastroenterology Authors: Sahaj Rathi, Silvia Brocco, Chiara Formentin, Lisa Zarantonello, Chiara Mangini, Gianluca Meneghello, Carlo Merkel, Paolo Angeli, Roberto Stramare, Sara Montagnese, Piero Amodio Tags: Liver, pancreas and biliary tract Source Type: research

Management of digestive cancers during the COVID-19 second wave: A French intergroup point of view (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, ACHBT, SFR)
The European second wave of the COrona VIrus Disease 2019 (COVID-19) pandemic requires us to think again our practice of digestive oncology. These proposals are based on a recent literature review, the first national digestive oncology guidelines group (TNCD) recommendations [1] and the experience of the first wave of the COVID-19 pandemic. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 16, 2020 Category: Gastroenterology Authors: David Tougeron, Pierre Michel, Astrid Li èvre, Michel Ducreux, Sébastien Gaujoux, Boris Guiu, Florence Huguet, Thierry Lecomte, Côme Lepage, Christophe Louvet, Léon Maggiori, Pascale Mariani, Thomas Aparicio, Olivier Bouché, Thésaurus National de Ca Tags: Guidelines Update Source Type: research

B-cell activating factor (BAFF) expression is associated with Crohn's disease and can serve as a potential prognostic indicator of disease response to Infliximab treatment
Several studies correlated elevated B-cell activating factor (BAFF) levels and its polymorphisms (SNPs) in patients with autoimmunity. Limited data existed regarding the role of BAFF in Crohn's Disease (CD) susceptibility and/or treatment response to infliximab. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 16, 2020 Category: Gastroenterology Authors: Nikolaos-Panagiotis Andreou, Evangelia Legaki, Nikolas Dovrolis, Nikola Boyanov, Konstantinos Georgiou, Kalliopi Gkouskou, Maria Gazouli Tags: Alimentary Tract Source Type: research

Systematic assessment of environmental factors for gastroesophageal reflux disease: An umbrella review of systematic reviews and meta-analyses
Side effects of long-term acid suppression have increased the scholars ’ interest in nonpharmacologic intervention. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 15, 2020 Category: Gastroenterology Authors: Yuan Cheng, Fushun Kou, Jiali Liu, Yi Dai, Xiaohong Li, Junxiang Li Tags: Review Article Source Type: research

Systemic steroids have a role in treating esophageal strictures in pediatric eosinophilic esophagitis
The role of systemic steroids in the treatment of esophageal strictures in children with Eosinophilic Esophagitis (EoE) is poorly defined. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 15, 2020 Category: Gastroenterology Authors: Assaf Hoofien, Francesca Rea, Maria do C éu Espinheira, Jorge Amil Dias, Claudio Romano, Salvatore Oliva, Marcus Karl-Heinz Auth, Tsili Zangen, Nicolas Kalach, Gloria Domínguez-Ortega, Paola De Angelis, Noam Zevit, for the ESPGHAN EGID Working Group Tags: Alimentary tract Source Type: research

Validation of fatty liver disease scoring systems for ultrasound diagnosed non-alcoholic fatty liver disease in adolescents
The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing in young populations. However, there are inadequate data regarding diagnosis of NAFLD. We aimed to validate three scoring systems against a previous standard of suprailiac skinfold thickness for diagnosing NAFLD in population-based adolescents. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 14, 2020 Category: Gastroenterology Authors: Fuzhen Wan, Feng Pan, Oyekoya T. Ayonrinde, Leon A. Adams, Trevor A. Mori, Lawrence J. Beilin, Therese A. O'Sullivan, John K. Olynyk, Wendy H. Oddy Tags: Liver, pancreas and biliary tract Source Type: research

Management of gastrointestinal tuberculosis during COVID pandemic: Lessons for posterity
The COVID pandemic has brought many challenges to the management of patients with tuberculosis. While the nationwide lockdown and closure of routine outpatient departments may have helped in controlling the pandemic, they brought out challenges in providing care to patients with chronic diseases like tuberculosis [1]. Diagnosis and management of extrapulmonary tuberculosis especially gastrointestinal tuberculosis (GITB) is difficult even during normal times and became even more challenging during lockdown. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 14, 2020 Category: Gastroenterology Authors: Jayendra Shukla, Anuraag Jena, Harjeet Singh, Harshal S. Mandavdhare, Usha Dutta, Vishal Sharma Tags: Correspondence Source Type: research

Association between lifestyle and site-specific advanced colorectal lesions in screening with faecal immunochemical test and sigmoidoscopy
Lifestyle factors may help to identify individuals at high-risk for colorectal cancer (CRC). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 10, 2020 Category: Gastroenterology Authors: Markus D. Knudsen, Edoardo Botteri, Øyvind Holme, Anette Hjartåker, Mingyang Song, Espen Thiis-Evensen, Espen R. Norvard, Anna L. Schult, Kristin R. Randel, Geir Hoff, Paula Berstad Tags: Digestive endoscopy Source Type: research

Reply to “Painless chronic pancreatitis with pancreatic duct stones”
We read with interest the letter from Liping Duan and colleagues entitled "Chronic pancreatitis with pancreatic duct stones", regarding a possible operative approach in patients with painless chronic pancreatitis. Interestingly, the Authors confirm the frequency of painless pancreatitis (around 10% of chronic pancreatitis) and the epidemiological characteristics of these patients observed in our paper. However, they suggest to treat patients with painless chronic pancreatitis and intraductal stones by operative endoscopic retrograde cholangio-pancreatography (ERCP) and /or extracorporeal shockwave lithotripsy (ES...
Source: Digestive and Liver Disease - December 8, 2020 Category: Gastroenterology Authors: Giulia De Marchi, Antonio Amodio, Luca Frulloni Tags: Correspondence Source Type: research

The gut –brain axis in irritable bowel syndrome and inflammatory bowel disease
Research increasingly demonstrates the bidirectional communication between gut microbiota and the brain, enhancing the role of gut microbiota modulation in the treatment of central nervous system (CNS) disorders. The first five years of life are extremely important as it affects the development of gut microbiota, immune system and, consequently, the onset of psychometric alterations, particularly in genetically predisposed individuals.In this review, we focus on the link between specific microbial genera, gastrointestinal (GI) disorders, anxiety and depression and on the effects of different therapeutic strategies for mood...
Source: Digestive and Liver Disease - December 7, 2020 Category: Gastroenterology Authors: Angela Ancona, Claudia Petito, Irene Iavarone, Valentina Petito, Linda Galasso, Alessia Leonetti, Laura Turchini, Daniela Belella, Daniele Ferrarrese, Giovanni Addolorato, Alessandro Armuzzi, Antonio Gasbarrini, Franco Scaldaferri Tags: Review Article Source Type: research

Ultrasound-guided stellate ganglion block alleviates stress responses and promotes recovery of gastrointestinal function in patients
This study aimed to investigate the effect of preoperative ultrasound-guided stellate ganglion block (SGB) on the perioperative stress responses and gastrointestinal functions of patients undergoing laparoscopic colorectal cancer surgery. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 7, 2020 Category: Gastroenterology Authors: Guoshao Zhu, Zhenming Kang, Yingle Chen, Jingyang Zeng, Changsheng Su, Shunyuan Li Tags: Alimentary tract Source Type: research

Vanek's tumor, a very rare case of massive acute gastrointestinal bleeding
A 52 year-old male with a recent acute myocardial infarction, treated with coronary angioplasty and stenting, and on dual antiplatelet therapy (DAPT), was admitted at our Gastroenterological Emergency Department for acute gastrointestinal bleeding (melena) and haemodynamic instability (blood pressure 95/55  mmHg, heart rate 112 bpm). He had haemoglobin 6.8 g/dL and metabolic acidosis. After resuscitation, he underwent urgent esophagogastroduodenoscopy (EGD), which did not reveal any sign of upper gastrointestinal bleeding. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 7, 2020 Category: Gastroenterology Authors: Nicola Imperatore, Martina Cargiolli, Amedeo Boscaino, Giovanni Lombardi Tags: Image of the Month Source Type: research

An unexpected lateral spreading lesion detected during colonoscopy
A 79-year-old male presented with diffuse abdominal pain and constipation. His-medical history included hypertension and benign prostatic hyperplasia. Physical examination revealed no abdominal distention and normal bowel sounds. Laboratory tests showed mild normocytic anemia (Hb 12.8  g/dL). Colonoscopy revealed a lateral spreading lesion in the transverse colon measuring25 mm, with redness areas but without surface or vascular changes. Biopsies were taken, showing morphological and immunophenotypic findings consistent with extranodal marginal zone lymphoma of mucosa-associa ted lymphoid tissue (MALT lymphoma) (Fig. (...
Source: Digestive and Liver Disease - December 2, 2020 Category: Gastroenterology Authors: Eduardo Dantas, Joana Santos, Cl áudia Cardoso, Ana Paula Oliveira Tags: Image of the Month Source Type: research

[ ¹¹C] choline as a potential PET/CT biomarker of liver cirrhosis: A prospective pilot study
To compare [ ¹¹C] choline PET/CT findings between patients with cirrhosis and normal liver controls. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - December 1, 2020 Category: Gastroenterology Authors: Hemda Schmilovitz-Weiss, Doron Boltin, David Groshar, Liran Domachevsky, Eli Rosenbaum, Nidal Issa, Boris Sapoznikov, Idan Goren, Assaf Issachar, Michal Cohen-Naftaly, Avraham Weiss, Rachel Gingold-Belfer, Hanna Bernstine Tags: Liver, Pancreas and Biliary Tract Source Type: research

Intelligent detection endoscopic assistant: An artificial intelligence-based system for monitoring blind spots during esophagogastroduodenoscopy in real-time
Observation of the entire stomach during esophagogastroduodenoscopy (EGD) is important; however, there is a lack of effective evaluation tools. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - November 30, 2020 Category: Gastroenterology Authors: Yan-Dong Li, Shu-Wen Zhu, Jiang-Ping Yu, Rong-Wei Ruan, Zhao Cui, Yi-Ting Li, Mei-Chao Lv, Huo-Gen Wang, Ming Chen, Chao-Hui Jin, Shi Wang Tags: Digestive Endoscopy Source Type: research

Direct visualization of an intraductal papillary neoplasm of the bile duct: A premalignant lesion of bile duct cancer
A 73-year-old man presented with abdominal pain and abnormal liver function. Approximately 20 years before, he had undergone cholecystectomy for cholecystitis. CT revealed mild bile duct dilatation without any intraductal stone or mass (Fig. 1A). Magnetic resonance cholangiopancreatography detected small stones in the common hepatic duct (CHD) just above the cystic duct insertion (Fig. 1B). However, endoscopic ultrasound (EUS) showed no typical findings of a stone (Fig.  1C). On contrast-enhanced EUS, the lesion was suspected to be a tumorous lesion owing to enhancement after contrast injection (Fig. 1D). (Source...
Source: Digestive and Liver Disease - November 28, 2020 Category: Gastroenterology Authors: Chi Hyuk Oh Tags: Image of the Month Source Type: research

Improving prognosis of patients with very early hepatocellular carcinoma: How far are we going?
The Times They Are a-Changin ’ (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - November 27, 2020 Category: Gastroenterology Authors: Edoardo G. Giannini Tags: Editorial Source Type: research

The diagnostic value of exosomal miRNAs in human bile of malignant biliary obstructions
Diagnosis of malignant biliary obstruction is complicated and lacks accuracy. Exosomes may be secreted by malignant tumors; intact miRNAs from exosomes might serve as potential biomarkers for the disease. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - November 27, 2020 Category: Gastroenterology Authors: Xianxiu Ge, Lingyu Tang, Youli Wang, Ni Wang, Jian Zhou, Xueting Deng, Yuan Zhong, Quanpeng Li, Fei Wang, Guobin Jiang, Lin Miao Tags: Liver, Pancreas and Biliary Tract Source Type: research

Remission of gastrointestinal follicular lymphoma after abatacept treatment against rheumatoid arthritis
A 67-year-old man was referred to our hospital for treatment of gastrointestinal follicular lymphoma (FL) in 2009. He had been treated with methotrexate for rheumatoid arthritis (RA) since 2000. Methotrexate was changed to salazosulfapyridine because of his FL. He was treated with rituximab monotherapy against FL and achieved complete remission. In 2014, a follow-up esophagogastroduodenoscopy (EGD) showed recurrent FL in his duodenum. The FL increased gradually until January 2018 (Fig. 1A). Pathologically, neoplastic lymphocytes had a follicular pattern (Fig. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - November 27, 2020 Category: Gastroenterology Authors: Takehiro Torisu, Yutaro Ihara, Shinichiro Kawatoko Tags: Image of the Month Source Type: research

Management of cholangiocarcinoma in the third millennium: time to be guided!
Cholangiocarcinoma (CCA) is a rare but devastating tumor and the second most frequent primary neoplasm of the liver [1]. Despite being considered infrequent, CCA is increasing its prevalence with regard to the less curable intrahepatic form (i-CCA). Diagnosis, management and therapy of CCA remain dismal and incidence and mortality are nearly comparable nowadays. To tackle the relevant clinical gap in therapeutics, an intense preclinical and clinical research effort has been conducted in the last decades. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - November 26, 2020 Category: Gastroenterology Authors: Marco Carbone, Leonardo Baiocchi Source Type: research

Editorial Board
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - November 26, 2020 Category: Gastroenterology Source Type: research

Complete resection of a previously unsuspected 5  mm duodenal submucosal carcinoma
A 56-year-old man  was found to have a flat-elevated lesion, 5 mm in diameter, located at the descending part of the duodenum. The lesion was endoscopically diagnosed as an adenoma (Fig. 1a, b). However, a histological diagnosis through biopsyrevealed that it was a well-differentiated adenocarcinoma. We performed endoscopic mucosal resection (EMR) with over-the-scope clip (OTSC) (referred to as EMRO) [1] using deep layer resection techniques to achieve a negative resection margin without perforation (Fig. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - November 25, 2020 Category: Gastroenterology Authors: Tomoaki Tashima, Kazuya Miyaguchi, Yuki Tanisaka, Shomei Ryozawa Tags: Image of the Month Source Type: research