Editorial Board
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 24, 2021 Category: Gastroenterology Source Type: research

A multisystem-compatible deep learning-based algorithm for detection and characterization of angiectasias in small-bowel capsule endoscopy. A proof-of-concept study.
Current artificial intelligence (AI)-based solutions for capsule endoscopy (CE) interpretation are proprietary. We aimed to evaluate an AI solution trained on a specific CE system (Pillcam ®, Medtronic) for the detection of angiectasias on images captured by a different proprietary system (MiroCam®, Intromedic). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 22, 2021 Category: Gastroenterology Authors: Charles Houdeville, Marc Souchaud, Romain Leenhardt, Hanneke Beaumont, Robert Benamouzig, Mark McAlindon, Sylvie Grimbert, Dominique Lamarque, Richard Makins, Jean-Christophe Saurin, Aymeric Histace, Xavier Dray Tags: Digestive Endoscopy Source Type: research

Cholangiocarcinoma with STRN-ALK translocation treated with ALK inhibitors
Biliary tract cancers (BTCs) are rare neoplasms that are mostly reported in first-world countries, with an incidence in Europe of approximately 1 per 100,000 inhabitants. BTCs are categorized as intrahepatic (iCCA), perihilar (pCCA), or distal cholangiocarcinomas (dCCA), or gallbladder carcinomas. Gemcitabine-platinum doublet chemotherapy is the standard-of-care in the first-line for advanced BTCs, giving an 8-month median progression-free-survival (PFS), with median overall survival ranging from 6 to 12 months [1]. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 20, 2021 Category: Gastroenterology Authors: Marine Valery, Francesco Facchinetti, David Malka, Michel Ducreux, Luc Friboulet, Antoine Hollebecque Tags: Correspondence Source Type: research

Collagen proportionate area predicts long-term mortality in patients with alcoholic hepatitis
There are several short-term prognostic scores for alcoholic hepatitis (AH) that combine demographical and biochemical parameters. The extent of liver fibrosis may also be relevant to the prognosis of AH with potential added value. We evaluated collagen proportionate area (CPA) as a predictor of short and long-term mortality in AH. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 19, 2021 Category: Gastroenterology Authors: Mads Israelsen, Marta Guerrero Misas, Anastasios Koutsoumourakis, Andrew Hall, Claudia Covelli, Elena Buzzetti, Laura Iogna Prat, Davide Roccarina, Tu Vinh Luong, Alberto Quaglia, Massimo Pinzani, Emmanuel A. Tsochatzis Tags: Liver, Pancreas and Biliary Tract Source Type: research

Multiple liver lesions leading to urgent referral
A young patient was referred urgently to our centre following an ultrasound scan which revealed multiple liver lesions. The patient was asymptomatic with no significant past medical history. Physical examination was normal. Liver function tests and liver screen were normal. Magnetic resonance imaging (MRI) revealed multiple small T2 hyper intense lesions throughout the liver (Figs.  1 and 2). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 18, 2021 Category: Gastroenterology Authors: Sreelakshmi Kotha, Philip Berry Tags: Image of the Month Source Type: research

External validation of Chronic Pancreatitis Prognosis Score(COPPS): A prospective cohort study
Prognostic stratification in ChronicPancreatitis(CP) remains suboptimal and cumbersome. Chronic Pancreatitis Prognostic Score(COPPS) was recently developed to predict one-year hospitalisations in CP. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 17, 2021 Category: Gastroenterology Authors: Ankit Maheshwari, Partha Sarathi Patra, Sukanta Ray, GK Dhali, Kshaunish Das Source Type: research

Effectiveness of adalimumab for ulcerative colitis: A multicentre, retrospective study of clinical practice in Italy
Adalimumab is used to treat ulcerative colitis, but additional effectiveness and safety data are needed. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 16, 2021 Category: Gastroenterology Authors: Alessandro Vitello, Mauro Grova, Daniela Pugliese, Fernando Rizzello, Francesco Lanzarotto, Alessandro Lavagna, Roberta Caccaro, Maria Cappello, Anna Viola, Davide Giuseppe Ribaldone, Mariabeatrice Principi, Elisa Stasi, Maria Lia Scribano, Marcello Maida Tags: Alimentary Tract Source Type: research

Clinicopathological features of Epstein-Barr virus –associated superficial early stage gastric cancer treated with endoscopic submucosal dissection
Epstein-Barr virus (EBV) is known to be involved in gastric carcinogenesis. EBV-associated early gastric carcinoma (EBVEGC) has a lower incidence of lymph node involvement and could be an expanded indication for endoscopic submucosal dissection (ESD) treatment. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 14, 2021 Category: Gastroenterology Authors: Yugo Suzuki, Naoko Inoshita, Daisuke Kikuchi, Kosuke Nomura, Akira Matsui, Shu Hoteya Tags: Oncology Source Type: research

Reversal of fibrosis in eosinophilic esophagitis: Another feather in the PPI cap?
Eosinophilic esophagitis (EoE) is an immune-antigen-mediated disease characterized by a transmural eosinophil-predominant inflammation of the esophagus [1]. Chronic uncontrolled eosinophilic inflammation ultimately leads to remodeling and alters the structure and function of the esophagus [2,3], with dysmotility [4], esophageal rigidity [5], progressive dysphagia and food impaction and, finally, stricture formation [6]. The endoscopic signs of EoE remodeling can be obvious with fibrostenotic features such as rings and strictures that cause food impaction [7,8]. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 13, 2021 Category: Gastroenterology Authors: Salvatore Oliva, Evan S. Dellon Tags: Commentary Source Type: research

Troglitazone inhibits hepatic oval cell proliferation by inducing cell cycle arrest through Hippo/YAP pathway regulation
Hepatic oval cells have strong proliferation and differentiation capabilities and are activated when chronic liver injury occurs or when liver function is severely impaired. Peroxisome proliferation-activated receptors (PPARs) are ligand-dependent, sequence-specific nuclear transcription factors. PPAR γ is closely related to liver diseases (such as liver cancer, liver fibrosis and non-alcoholic fatty liver disease). As the main effector downstream of the Hippo signaling pathway, YAP can activate the hepatic progenitor cell program, and different expression or activity levels of YAP can determine different liver cell ...
Source: Digestive and Liver Disease - September 13, 2021 Category: Gastroenterology Authors: Yifeng He, Haijian Li, Yunhe He, Caijie Lu, Peiyi Zhu, Mingyi Li, Juan Duan, Zhixin Fang Tags: Liver, Pancreas and Biliary Tract Source Type: research

Does capsule endoscopy impact clinical management in established Crohn's disease?
Capsule endoscopy (SBCE) has developed a relevant role in patients with established Crohn's Disease (CD). However, evaluation of the impact in clinical management has been scarce. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 10, 2021 Category: Gastroenterology Authors: Alfonso Elosua, Mar ía Rullan, Saioa Rubio, Susana Oquiñena, Cristina Rodríguez, Elena Macías, Ana Borda, Ignacio Fernández-Urién, Óscar Nantes Tags: Digestive Endoscopy Source Type: research

Outcome of pregnancy in patients with primary sclerosing cholangitis
Data on the clinical course of primary sclerosing cholangitis (PSC) during pregnancy remain scarce. Herein, we assessed the maternal and fetal outcomes of pregnancy in this condition. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 10, 2021 Category: Gastroenterology Authors: Karolina M. Wronka, Emil Bik, Piotr Milkiewicz Tags: Liver, Pancreas and Biliary Tract Source Type: research

ANTI-SARS-CoV-2 IMMUNOGLOBULIN PROFILE IN PATIENTS WITH CELIAC DISEASE LIVING IN A HIGH INCIDENCE AREA
How symptoms and antibodies related to SARS-CoV-2 infection develop in patients with celiac disease (CD) is unclear. We aimed to investigate the impact of SARS-CoV-2 infection in CD patients. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 9, 2021 Category: Gastroenterology Authors: Luca Elli, Federica Facciotti, Vincenza Lombardo, Alice Scricciolo, David S. Sanders, Valentina Vaira, Donatella Barisani, Maurizio Vecchi, Andrea Costantino, Lucia Scaramella, Bernardo dell'Osso, Luisa Doneda, Leda Roncoroni Tags: Alimentary Tract Source Type: research

Future challenges in gastroenterology and hepatology, between innovations and unmet needs: A SIGE Young Editorial Board's perspective
Gastroenterology, Digestive Endoscopy and Hepatology have faced significant improvements in terms of diagnosis and therapy in the last decades. However, many fields still remain poorly explored, and many questions unanswered. Moreover, basic-science, as well as translational and clinical discoveries, together with technology advancement will determine further steps toward a better, refined care for many gastroenterological disorders in the future. Therefore, the Young Investigators of the Italian Society of Gastroenterology (SIGE) joined together, offering a perspective on major future innovations in some hot clinical topi...
Source: Digestive and Liver Disease - September 8, 2021 Category: Gastroenterology Authors: Giuseppe Losurdo, Antonietta Gerarda Gravina, Luca Maroni, Enrico Maria Gabrieletto, Gianluca Ianiro, Alberto Ferrarese, Young Investigator group of SIGE, the Italian Society of Gastroenterology Tags: Review Article Source Type: research

Genes and lifestyle: Which of the two is more relevant in driving NAFLD progression?
A wide spectrum of factors conjointly operate in the pathogenesis of NAFLD and in liver disease progression towards advanced liver disease and comorbidities [1]. At one extreme we find genetic factors: they provide mechanism(s) facilitating liver fat accumulation well before birth, as expressed by epigenetic studies [2], and are operative throughout life. In recent years several studies have shown that a lot of gene polymorphisms are associated with an increased risk of NAFLD, variably linked with obesity, with the risk of cardiovascular events, with the risk of progression to hepatocellular cancer [3]. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 8, 2021 Category: Gastroenterology Authors: Giulio Marchesini, Roy Taylor Tags: Commentary Source Type: research

The safety and efficacy evaluation of Sodium-Glucose co-transporter 2 inhibitors for patients with non-alcoholic fatty Liver disease: An updated meta-analysis
In recent years, sodium-glucose co-transporter 2 inhibitors (SGLT2is) have been increasingly used in the treatment of patients with non-alcoholic fatty liver disease (NAFLD). This updated meta-analysis aimed to evaluate the efficacy and safety of SGLT2is for patients with NAFLD. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 7, 2021 Category: Gastroenterology Authors: Manqiu Mo, Zichun Huang, Yuzhen Liang, Yunhua Liao, Ning Xia Tags: Meta-Analysis Source Type: research

Synchronous organ failure and infected pancreatic necrosis define genuine critical acute pancreatitis
Critical acute pancreatitis (CAP) was supposed to be strongly associated with the highest risk of adverse outcomes. However, the definition of CAP needs to be further clarified. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 6, 2021 Category: Gastroenterology Authors: Dingcheng Shen, Qin Wei, Haosu Huang, Caihong Ning, Jiarong Li, Lu Chen, Shuai Zhu, Gengwen Huang Tags: Liver, Pancreas and Biliary Tract Source Type: research

Tumor-derived extracellular vesicles containing long noncoding RNA PART1 exert oncogenic effect in hepatocellular carcinoma by polarizing macrophages into M2
We explored whether tumor-derived extracellular vesicles (EVs) could deliver long noncoding RNA (lncRNA) PART1 into macrophage to orchestrate macrophage polarization in the progression of hepatocellular carcinoma (HCC). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 5, 2021 Category: Gastroenterology Authors: Jingyang Zhou, Jinhui Che, Lu Xu, Weizhong Yang, Wuyuan Zhou, Cuncai Zhou Tags: Oncology Source Type: research

Safe pregnancy after liver transplantation: Evidence from a multicenter Italian collaborative study
Women who have undergone liver transplantation (LT) enjoy better health, and possibility of childbearing. However, maternal and graft risks, optimal immunosuppression, and fetal outcome is still to clarify. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 5, 2021 Category: Gastroenterology Authors: Salvatore Stefano Sciarrone, Alberto Ferrarese, Debora Bizzaro, Sofia Volpato, Francesca Maria Donato, Federica Invernizzi, Laura Trespidi, Ilaria Giuditta Ramezzana, Alfonso Wolfango Avolio, Erida Nure, Marco Maria Pascale, Stefano Fagiuoli, Luisa Pasulo Tags: Liver, Pancreas and Biliary Tract Source Type: research

Acute pancreatitis following endoscopic ultrasonography-guided tissue acquisition for gastric ectopic pancreas
A 37-year-old man was referred to our hospital for further evaluation of the gastric subepithelial lesion accidentally found during screening gastroscopy. The lesion was located on the greater curvature of the gastric body (Fig.  1a). Abdominal computed tomography (CT) demonstrated a 25-mm-diameter homogenously enhanced mass in the gastric wall (Fig. 1b). Endoscopic ultrasonography (EUS) showed a heterogeneous submucosal mass in the 3rd layer of the gastric wall (Fig. 1c). EUS-guided tissue acquisition (EUS-TA) was perfo rmed in three passes using a 22-gage Franseen needle (Acquire; Boston Scientific, Marlbo...
Source: Digestive and Liver Disease - August 31, 2021 Category: Gastroenterology Authors: Noriko Juri, Kosuke Minaga, Yoshito Uenoyama, Yukitaka Yamashita Tags: Image of the Month Source Type: research

Returning to endoscopy normality through the support of a new non-invasive faecal test based on microbial signatures
During the height of the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many healthcare facilities needed to focus on screening for and treating patients with known or suspected COVID-19 [1]. This resulted in the diversion of healthcare workers and resources leading to the stop of colorectal cancer (CRC) primary screening and an alarming reduction in endoscopy activity during the COVID-19 pandemic, affecting and changing the daily practice of gastrointestinal endoscopy (both diagnostic and therapeutic) and will do so for the foreseeable future. (Sou...
Source: Digestive and Liver Disease - August 30, 2021 Category: Gastroenterology Authors: M. Malag ón, L. Oliver, S. Ramió-Pujol, J. Guardiola, F. Balaguer Tags: Correspondence Source Type: research

Liver involvement in patients with erythropoietic protoporphyria
In erythropoietic protoporphyria (EPP), which presents with severe painful phototoxicity, progressive deposition of protoporphyrins in hepatocytes and bile canaliculi may result in liver disease. Clinically EPP related liver disease ranges from mildly elevated liver enzymes to cirrhosis and acute cholestatic hepatic failure. The prevalence of liver disease in EPP, and factors predicting the risk of developing liver disease, have not been defined in a large series of unselected EPP patients. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 30, 2021 Category: Gastroenterology Authors: Debby Wensink, Sandra Coenen, J.H. Paul Wilson, Margreet A.E.M. Wagenmakers, Janneke G. Langendonk Tags: Liver, Pancreas and Biliary Tract Source Type: research

First-line chemotherapy with raltitrexed in metastatic colorectal cancer: an Association des Gastro-ent érologues Oncologues (AGEO) multicentre study
In case of contraindication or intolerance to fluoropyrimidines, raltitrexed is a validated alternative in metastatic colorectal cancer (mCRC), associated or not with oxaliplatin. Little is known about the outcomes of raltitrexed combined with irinotecan or targeted therapies. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 29, 2021 Category: Gastroenterology Authors: Claire Gallois, Emilie Hafliger, Edouard Auclin, Audrey Perret, Cl élia Coutzac, Anthony Turpin, Anna Pellat, Violaine Randrian, Debora Basile, Roger Faroux, Simon Pernot, Christophe Locher, Vincent Hautefeuillle, Olivier Dubreuil, Lola-Jade Palmieri, Ma Tags: Oncology Source Type: research

Editorial Board
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 26, 2021 Category: Gastroenterology Source Type: research

M probe comes first: Impact of initial probe choice on diagnostic performance of vibration controlled transient elastography
Probe choice (M or XL) in transient elastography can be made by the user's own measure of skin-to-liver-capsule distance (SCD) or with an automated tool (AUTO). We studied how AUTO depends on initial probe choice. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 23, 2021 Category: Gastroenterology Authors: Valentin Blank, David Petroff, Johannes Wiegand, Thomas Karlas Tags: Liver, Pancreas and Biliary Tract Source Type: research

Implementing pre-procedural thrombopoietin receptor agonists in cirrhotic patients with severe thrombocytopenia: Indiscriminate, selective or unneeded?
Recent studies promote thrombopoietin-receptor agonists (TRAs), instead of platelet transfusions, before elective invasive procedures in patients with cirrhosis and platelet count below 50  × 109/L [1–6] to prevent procedure-related bleeding. In the current issue of Digestive and Liver Disease the systematic review and meta-analysis by Rose and colleagues [7] confirms that TRAs significantly decrease the amount of the supposed required platelet transfusions. At variance with plat elet transfusions, which have a slight and short-term effect on the platelet count, second generation TRAs more often achie...
Source: Digestive and Liver Disease - August 23, 2021 Category: Gastroenterology Authors: M. Primignani, G. Tosetti, A. Tripodi Tags: Commentary Source Type: research

Risk of developing metachronous colorectal neoplasia after the resection of proximal versus distal adenomas
Current post-polypectomy guidelines do not consider adenoma location. We compared the risk of metachronous colorectal neoplasia (CRN) according to adenoma location. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 22, 2021 Category: Gastroenterology Authors: Yoon Suk Jung, Nam Hee Kim, Youngwoo Kim, Dong Il Park Tags: Oncology Source Type: research

The sex discrepancy effects of fruit and vegetable intake on pancreatic cancer risk; a large Korean cancer screening cohort study
Although several risk factors have been identified for the development of pancreatic cancer, the effects of fruit and vegetables on the disease remains controversial. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 21, 2021 Category: Gastroenterology Authors: Su Youn Nam, Junwoo Jo, Won Kee Lee, Chang Min Cho Tags: Liver, Pancreas and Biliary Tract Source Type: research

Systematic review with meta-analysis: The prevalence, risk factors and outcomes of upper gastrointestinal tract crohn's disease
Upper gastrointestinal Crohn's disease (UGI-CD) is an important subclassification of Crohn's Disease (CD). We performed a systematic review and meta-analysis to evaluate the prevalence, risk factors, and clinical outcomes associated with UGI-CD. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 16, 2021 Category: Gastroenterology Authors: Yip Han Chin, Cheng Han Ng, Snow Yunni Lin, Sneha Rajiv Jain, Gwyneth Kong, Jeffery Wei Heng Koh, Darren Jun Hao Tan, David Eng Hui Ong, Mark Dhinesh Muthiah, Choon Seng Chong, Fung Joon Foo, Rupert Leong, Webber Pak Wo Chan Tags: Meta-Analysis Source Type: research

A rare cause of dysphagia due to Cicatricial Pemphigoid
A 68-year-old Hispanic woman presented with four months of dysphagia, odynophagia, and voice hoarseness. Computerized Tomography (CT) of the neck and chest was significant for thickening of epiglottis, dilated saccules, lymphadenopathy, and tracheal nodules. Laryngoscopy showed diffuse erythema and inflammation of oropharyngeal consistent with mucositis. Exam was positive for bilateral symblepharon, oral mucositis, as well as vulvar ulceration. Upper endoscopy showed esophagitis with sloughing mucosa and bullae along with a benign appearing esophageal stenosis in the proximal esophagus (Fig.  1). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 16, 2021 Category: Gastroenterology Authors: Samuel Jo, Peter Dellatore, Katherine M. Morgan, Anish Vinit Patel Tags: Image of the Month Source Type: research

Accurate and detailed research methods are crucial for natural history research of recurrent acute pancreatitis: Author's reply
We appreciate all the observations from Hu et al. and acknowledge that a prospective study is more suitable to understand the natural history of idiopathic recurrent acute pancreatitis (IRAP) and recurrent acute pancreatitis (RAP, with or without gene mutations) [1]. In our study we confirmed that IRAP is a narrow clinical entity, and once the recommended laboratories and imaging are completed, it only affects a minority of patients. Because of that, we could only identify 35 patients over 20 years in a network of three hospitals (all hospitals adding up to 1366 licensed beds) [2]. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 16, 2021 Category: Gastroenterology Authors: Luisa M. Cruz, Juan E. Corral Tags: Correspondence Source Type: research

Accurate and detailed research methods are crucial for natural history research of recurrent acute pancreatitis
We have read with great interest the article by Luisa M. Cruz et  al [1] concerning natural history of Idiopathic Recurrent Acute Pancreatitis (IRAP) and Recurrent Acute Pancreatitis (RAP) with genetic mutations. We believe that the natural history research of RAP or IRAP is very important, especially for the relationship between IRAP and Chronic Pancreatitis (C P). However, we think that the statistical and research method of this article could be improved. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 14, 2021 Category: Gastroenterology Authors: Di Zhang, Xi Lin, Yan-wei Lv, Zhao-shen Li, Liang-hao Hu Tags: Correspondence Source Type: research

Development of machine learning model to detect fibrotic non-alcoholic steatohepatitis in patients with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) has a direct medical cost of> $ 100 billion annually and is projected to be the leading cause of liver transplantation in the United States of America (USA) [1]. Non-alcoholic steatohepatitis (NASH) is a risk factor for liver fibrosis which portends poor prognosis however not all NASH patients progress to fibrosis. Fibrotic-NA SH represents NASH at high risk of progression to cirrhosis and is an important indication for enrollment in clinical trials [2]. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 13, 2021 Category: Gastroenterology Authors: Manik Aggarwal, Daniel Rozenbaum, Agam Bansal, Rajat Garg, Parikshit Bansal, Arthur McCullough Tags: Correspondence Source Type: research

Angiotensin II receptor antagonist (Olmesartan) associated gastro-entero-colopathy. The multiform expressions of damage due to this class of drugs
The angiotensin II receptor antagonists, also known as angiotensin receptor blockers (ARBs), are a family of drugs that inhibit the renin-angiotensin system by binding to and inhibiting the angiotensin II type 1 receptor (AT1). The ARBs comprise eight agents with similar activity but different pharmacokinetics [1]. In 1995 Losartan was the first ARB approved by the Food and Drug Administration for the treatment of hypertension followed by Valsartan (1996), Irbesartan (1997), Eprosartan (1997), Candesartan (1998), Telmisartan (1998), Olmesartan (2002) and Azilsartan (2011). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 13, 2021 Category: Gastroenterology Authors: V. Villanacci, R. Del Sordo Tags: Commentary Source Type: research

Efficacy and safety of direct oral anticoagulants versus vitamin K antagonist for portal vein thrombosis in cirrhosis: A systematic review and meta-analysis
Portal vein thrombosis (PVT) is associated with a higher risk of liver-related complications. Recent guidelines recommend direct-acting anticoagulants (DOAC) in patients with cirrhosis and non-tumoral PVT. However, data on the efficacy and safety of DOAC in these patients remain limited. We aim to investigate the efficacy and safety of DOAC compared to vitamin K antagonists (VKA) to treat non-tumoral PVT in patients with cirrhosis. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 12, 2021 Category: Gastroenterology Authors: Jin Hean Koh, Zi Hui Liew, Gin Kee Ng, Hui Ting Liu, Yew Chong Tam, Andrea De Gottardi, Yu Jun Wong Tags: Meta-Analysis Source Type: research

Metastatic colorectal carcinoma with signet-ring cells: Clinical, histological and molecular description from an Association des Gastro-Ent érologues Oncologues (AGEO) French multicenter retrospective cohort
Metastatic signet-ring cell colorectal carcinoma is rare. We analyzed its clinicopathological and molecular features, prognostic factors and chemosensitivity. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 9, 2021 Category: Gastroenterology Authors: Marion Allart, Florence Leroy, Stephano Kim, David Sefrioui, Mihane Nayeri, Aziz Zaanan, Benoit Rousseau, Meher Ben Abdelghani, Christelle de la Fouchardi ère, Wulfran Cacheux, Romain Legros, Samy Louafi, David Tougeron, Olivier Bouché, Nadim Fares, Gui Tags: Oncology Source Type: research

Exosomal microRNA-25 released from cancer cells targets SIK1 to promote hepatocellular carcinoma tumorigenesis
Hepatocellular carcinoma (HCC) is recognized as a leading cause of cancer-associated fatality worldwide. Our study here aimed to probe the mechanism by which exosomes secreted by CSQT-2, an HCC cell line, affected the progression of HCC. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 9, 2021 Category: Gastroenterology Authors: Xiaoyu Fu, Yujing Tang, Wanfeng Wu, Yi Ouyang, Deming Tan, Yan Huang Tags: Oncology Source Type: research

The wide phenotypic and genetic spectrum of ABCB4 gene deficiency: A case series
ABCB4-gene mutations are responsible for several cholestatic diseases with a heterogeneous clinical spectrum. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 8, 2021 Category: Gastroenterology Authors: Daniela Falc ão, Isabel Pedroto, Teresa Moreira Tags: Liver, Pancreas and Biliary Tract Source Type: research

Delays in urgent endoscopic interventions in a gastrointestinal endoscopy referral center and dedicated COVID unit: Riding the waves?
Since the start of the COVID-19 pandemic [1], major healthcare protocol overhauls have been enforced worldwide in order to contain the disease. Due to system-wide reduced availability and because endoscopic interventions were considered to carry a high risk of transmission [2], local practices suffered significant changes including strict prioritization and increased waiting time for most endoscopic procedures. Position statements issued by expert societies offered guidance [3] on procedure stratification according to the level of emergency, but many decisions were still taken on a case-by-case basis, leading to inhomogeno...
Source: Digestive and Liver Disease - August 8, 2021 Category: Gastroenterology Authors: Andrei Voiosu, Bianca Alexandra Dinescu, Andreea Bengu ș, Radu Bogdan Mateescu, Mihail Radu Voiosu, Theodor Voiosu Tags: Correspondence Source Type: research

POST COVID-19 Cholangiopathy – A Deep Dive
Enteric symptoms are significant in COVID-19 and are sometimes the only symptoms presented by the patient [1]. The common gastrointestinal symptom reported among COVID-19 patients is lack of appetite, nausea, vomiting, diarrhea and abdominal pain/discomfort [1]. Alteration in respiratory tract microbial flora can damage the gastrointestinal tract through immune activation, also known as the ‘gut-lung-axis’ [2]. When the infection is directly through the gastrointestinal tract, it can spread to the respiratory tract through blood [2]. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 8, 2021 Category: Gastroenterology Authors: Lakshmi Deepak Bethineedi, Tarun Kumar Suvvari Tags: Correspondence Source Type: research

Clinical impact of videocapsule and double balloon enteroscopy on small bowel bleeding: results from a large monocentric cohort in the last 19 years
Suspected small bowel bleeding (SSBB) is the main indication for videocapsule endoscopy (VCE) and double balloon enteroscopy (DBE). We assessed the impact of both modalities in a large cohort of SSBB patients in a European tertiary center. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 7, 2021 Category: Gastroenterology Authors: Luca Elli, Lucia Scaramella, Gian Eugenio Tontini, Matilde Topa, Dario Conte, Reena Sidhu, Emanuele Rondonotti, Roberto Penagini, Maurizio Vecchi Tags: Digestive Endoscopy Source Type: research

Pre-procedural use of thrombopoietin-receptor agonists in cirrhosis and severe thrombocytopenia: A systematic review and meta-analysis
Severe thrombocytopenia in cirrhosis can preclude invasive procedures. Platelet transfusion is recommended if platelet count pre-procedure is potential alternative to platelet transfusion is thrombopoietin-receptor (TPO) agonists. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 7, 2021 Category: Gastroenterology Authors: Peter D. Rose, Minnie Au, Richard J. Woodman, Derrick Tee, Mohamad A Chinnaratha Tags: Meta-Analysis Source Type: research

GLP-1 receptor agonists and reduction of liver fat content in NAFLD patients: Just a question of weight loss?
Glucagon-like peptide 1 (GLP-1) is an endogenous intestinal hormone which promotes insulin secretion in response to (oral) glucose [1,2]. GLP-1 receptor agonists (such as exenatide, liraglutide, dulaglutide and semaglutide) are a class of glucose-lowering drugs, approved for the treatment of type 2 diabetes (T2DM), able to improve glycemic control (with a HbA1c reduction ranging from −1% to −1.5%), insulin resistance, as well as to promote significant weight loss (on average 3–5 kg) [1,2]. In genetically induced and diet-induced diabetic mice, rats and rhesus macaques, GLP-1 receptors have been docum...
Source: Digestive and Liver Disease - August 5, 2021 Category: Gastroenterology Authors: Alessandro Mantovani Tags: Correspondence Source Type: research

Difficult biliary cannulation in patients with distal malignant biliary obstruction: An underestimated problem?
Failed biliary cannulation still poses a major challenge in patients undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP). To date, there is a lack of data on rates of Difficult Biliary Cannulation (DBC) in patients with distal malignant biliary obstruction (DMBO). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 4, 2021 Category: Gastroenterology Authors: Alessandro Fugazza, Edoardo Troncone, Arnaldo Amato, Ilaria Tarantino, Andrea Iannone, Giulio Donato, Ferdinando D'Amico, Giuseppe Mogavero, Michele Amata, Carlo Fabbri, Franco Radaelli, Pietro Occhipinti, Alessandro Repici, Andrea Anderloni Tags: Liver, Pancreas and Biliary Tract Source Type: research

FAPI PET/CT research progress in digestive system tumours
18F-fluorodeoxyglucose positron emission tomography/computed tomography has been used in clinical practice for many years. This modality is of great value for tumour diagnosis, staging, and efficacy evaluations, but it has many limitations in the diagnosis and treatment of digestive system tumours. Fibroblast activation protein is highly expressed in gastrointestinal tumours. Various isotope-labelled fibroblast activation protein inhibitors are widely used in clinical research. These inhibitors have low background uptake in the brain, liver and oral/pharyngeal mucosa and show good contrast between the tumour and background...
Source: Digestive and Liver Disease - August 4, 2021 Category: Gastroenterology Authors: Dengsai Peng, Jing He, Hanxiang Liu, Jianpeng Cao, Yingwei Wang, Yue Chen Tags: Review Article Source Type: research

“Positron emission tomography for the diagnosis of tipsitis”
Sustained bacteremia associated with endovascular infection of transjugular intrahepatic portosystemic shunts (TIPS) is a rare but potentially severe complication in patients with a TIPS placed for the treatment and/or prevention of portal hypertension-related complications. The term tipsitis was first introduced by Sanyal and Reddy in 1998 and was defined as the occurrence of fever with positive blood cultures and either a thrombus or vegetations on the stent, or persistent bacteremia in a patient with a TIPS and no other detectable source of infection despite an extensive search [1]. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 2, 2021 Category: Gastroenterology Authors: Alejandro Lopez-Jerez, Rosa Martin-Mateos, Jes ús Fortun, Teresa Navarro, Agustín Albillos, Javier Graus Tags: Correspondence Source Type: research

Intercellular crosstalk of liver sinusoidal endothelial cells in liver fibrosis, cirrhosis and hepatocellular carcinoma
Intercellular crosstalk among various liver cells plays an important role in liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Capillarization of liver sinusoidal endothelial cells (LSECs) precedes fibrosis and accumulating evidence suggests that the crosstalk between LSECs and other liver cells is critical in the development and progression of liver fibrosis. LSECs dysfunction, a key event in the progression from fibrosis to cirrhosis, and subsequently obstruction of hepatic sinuses and increased intrahepatic vascular resistance (IHVR) contribute to development of portal hypertension (PHT) and cirrhosis. (Sou...
Source: Digestive and Liver Disease - August 2, 2021 Category: Gastroenterology Authors: Hui Li Tags: Review Article Source Type: research

Acute variceal bleeding and out-of-hours endoscopy: Evaluation of an emergency care setting according to baveno VI guidelines adherence
The extent to which patients with acute variceal bleeding (AVB) receive recommended care is largely unknown. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 2, 2021 Category: Gastroenterology Authors: Joana Alves da Silva, Daniela Falc ão, Luís Maia, Tiago Pereira Guedes, Mónica Garrido, Maria Inês Novo, Marta Rocha, Pedro Pinto, Teresa Moreira, José Manuel Ferreira, Isabel Pedroto Tags: Digestive Endoscopy Source Type: research

Clinical efficacy, drug sustainability and serum drug levels in Crohn's disease patients treated with ustekinumab – A prospective, multicenter cohort from Hungary
Although efficacy of ustekinumab (UST) has been demonstrated through randomized trials, data from real-life prospective cohorts are still limited. Our aim was to evaluate clinical efficacy, drug sustainability, dose intensification and results from therapeutic drug monitoring in UST treated patients with Crohn's disease (CD) using a prospective, nationwide, multicenter cohort. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 2, 2021 Category: Gastroenterology Authors: Lorant Gonczi, Kata Szanto, Klaudia Farkas, Tamas Molnar, Tamas Szamosi, Eszter Schafer, Petra A. Golovics, Laszlo Barkai, Livia Lontai, Barbara Lovasz, Mark Juhasz, Arpad Patai, Krisztina Sarang, Aron Vincze, Patricia Sarlos, Alexandra Farkas, Zsolt Dubr Tags: Alimentary Tract Source Type: research

Genetic predisposition, lifestyle risk, and obesity associate with the progression of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is prevalent worldwide. We aim to identify the factors promoting NAFLD progression. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 2, 2021 Category: Gastroenterology Authors: Zhenqiu Liu, Chen Suo, Renjia Zhao, Huangbo Yuan, Li Jin, Tiejun Zhang, Xingdong Chen Tags: Liver, Pancreas and Biliary Tract Source Type: research