Post-infectious ibs following Clostridioides difficile infection; role of microbiota and implications for treatment
Up to 25% of patients recovering from antibiotic-treated Clostridioides difficile infection (CDI) develop functional symptoms reminiscent of Post-Infectious Irritable Bowel Syndrome (PI-IBS). For patients with persistent symptoms following infection, a clinical dilemma arises as to whether to provide additional antibiotic treatment or to adopt a conservative symptom-based approach. Here, we review the literature on CDI-related PI-IBS and compare the findings with PI-IBS. We review proposed mechanisms, including the role of C. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 22, 2024 Category: Gastroenterology Authors: Dana Taghaddos, Zarwa Saqib, Xaiopeng Bai, Premysl Bercik, Stephen M. Collins Tags: Review Article Source Type: research
Assessing ChatGPT and perplexity AI performance
This study assessed ChatGPT 3.5 and Perplexity AI's performance in answering gastroenterology-related questions from the 2023 Italian national residency admissi on test (SSM23). The study contrasted the chatbots' performance and concordance with test results from prior years. The procedures comprised feeding SSM23 questions into the chatbots and calculating the sum of their scores and right answers. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 22, 2024 Category: Gastroenterology Authors: Hinpetch Daungsupawong, Viroj Wiwanitkit Tags: Correspondence Source Type: research
Gastritis cystica profunda presenting as an ulcerated lesion
A 57-year-old man was referred to our hospital due to repeated upper abdominal discomfort for more than 1 year. Endoscopy was performed 4 times in the past and gastric cancer was suspected, but biopsy showed inflammation. In our hospital, endoscopy showed a 2.5 cm diameter depressed lesion on the gastric angle (Fig. 1A) and magnifying narrow band imaging observed the central surface structure of the lesion disappeared (Fig. 1B). Endoscopic ultrasound (EUS) revealed a 0.8 × 0.7 cm anechoic area in the submucosa (Fig. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 22, 2024 Category: Gastroenterology Authors: Yang Li, Ruide Liu, Ziqiang Wang, Yi Mou Tags: Image of the Month Source Type: research
A case of refractory severe pyoderma gangrenosum successfully treated with upadacitinib
A 59-year-old woman affected by colonic Crohn's disease and perianal disease underwent colectomy and end ileostomy. Persistently active luminal disease was associated with severe pyoderma gangrenosum localized to the upper and lower limbs. Previous treatments with intravenous steroids and infliximab were not effective on pyoderma gangrenosum lesions. The image shows the evolution of a large and deep lesion localized on the right hand, after starting upadacitinib 45 mg once a day, with clear improvement and almost complete healing in 6 weeks of treatment (Fig. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 21, 2024 Category: Gastroenterology Authors: Marco Mendolaro, Enrico Morello, Paola Salacone, Rodolfo Rocca Tags: Image of the Month Source Type: research
Artificial intelligence-assisted colonoscopy to identify histologic remission and predict the outcomes of patients with ulcerative colitis: A systematic review
This systematic review evaluated the current status of AI-assisted colonoscopy to identify histologic remission and predict the clinical outcomes of patients with ulcerative colitis. The use of artificial intelligence (AI) has increased substantially across several medical fields, including gastrointestinal endoscopy. Evidence suggests that it may be helpful to predict histologic remission and relapse, which would be beneficial because current histological diagnosis is limited by the inconvenience of obtaining biopsies and the high cost and time-intensiveness of pathological diagnosis. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 21, 2024 Category: Gastroenterology Authors: Yasuharu Maeda, Shin-ei Kudo, Giovanni Santacroce, Noriyuki Ogata, Masashi Misawa, Marietta Iacucci Tags: Alimentary Tract Source Type: research
Author's reply: “Assessing ChatGPT and perplexity AI performance”
None. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 21, 2024 Category: Gastroenterology Authors: Raffaele Pellegrino, Antonietta Gerarda Gravina Tags: Correspondence Source Type: research
Comment on “Echopattern parameter as an aid to profile Crohn's disease patients”
With a great interest in its subject matter, we extensively reviewed and analyzed an interesting article that was recently published by your journal, entitled “Echopattern parameter as a tool for characterizing Crohn's disease patients' profiles [1]”, authored by Cristofaro et al. We commend the Authors for their innovative efforts. Their core findings suggest that the assessment of bowel wall echopattern enables the differentiation of various Crohn's Disease (CD) behaviors, particularly noting that a hypoechoic echopattern correlates with both clinical and ultrasonographic (US) markers of inflammation, as well as poor...
Source: Digestive and Liver Disease - April 19, 2024 Category: Gastroenterology Authors: Muhammad Rafay Shahzad Cheema, Mukarram Farooq, Urba Jalal, Maryum Shahzad Tags: Correspondence Source Type: research
Magnetic resonance imaging short protocols for intraductal papillary mucinous neoplasm (IPMN) surveillance: The time has come
To analyze the diagnostic performance of three short magnetic resonance imaging (MRI) protocols for the follow-up of pancratic intraductal papillary mucinous neoplasms (IPMN). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 13, 2024 Category: Gastroenterology Authors: Mirko D'Onofrio, Luca Geraci, Riccardo Lombardi De Robertis, Nicol ò Cardobi, Alberto Balduzzi, Luisa Tomaiuolo, Eda Bardhi, Niccolò Faccioli, Gregorio Aluffi, Giovanni Marchegiani, Roberto Salvia Tags: Liver, Pancreas and Biliary Tract Source Type: research
Oral Budesonide and low serum albumin levels at surgery are associated with a higher risk of postoperative intra-abdominal septic complications after primary ileocaecal resection for Crohn's disease: A retrospective analysis of 853 consecutive patients
The terminal ileum is the most frequent site of Crohn's Disease (CD) that necessitates surgery. Of the postoperative complications (POCs) associated with ileocaecal resection for CD, intra-abdominal septic complications (IASCs) include anastomotic leak, abscesses, and entero-cutaneous fistula.We aimed to identify predictors of IASCs and severe POCs (Clavien-Dindo ≥3) after primary ileocaecal resection for CD. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 13, 2024 Category: Gastroenterology Authors: Gerti Dajti, Stefano Cardelli, Giacomo Calini, Fernando Rizzello, Paolo Gionchetti, Maria Elena Flacco, Gilberto Poggioli, Matteo Rottoli Tags: Alimentary Tract Source Type: research
Whether and when to biopsy coeliac patients: A never-ending story
Coeliac disease (CD) is an autoimmune enteropathy that primarily affects the small intestine, causing mucosal inflammation and variable villous atrophy. It occurs in genetically predisposed subjects following the ingestion of gluten, a protein complex of cereals such as wheat, barley, rye, whose main fractions are prolamins (including gliadin) and gluten [1]. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 13, 2024 Category: Gastroenterology Authors: Salvatore Cucchiara, Beatrice Leter Tags: Editorial Source Type: research
Controversies in medical vs surgical management of ileocecal crohn's disease
Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) characterized by periods of relapsing luminal inflammation alternating with clinical remissions. Such chronic intestinal inflammation might lead to progressive bowel structural damage, resulting in the development of complications [1]. The Montreal classification perfectly reflects this natural history, describing a non-complicated, strictly inflammatory, CD behavior (B1 phenotype) and two complicated CD phenotypes: the stricturing CD behavior (B2) and the perforating CD behavior (B3). (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 13, 2024 Category: Gastroenterology Authors: L éon Maggiori, David Laharie Tags: Forum Source Type: research
Author's reply: “Bile reflux is associated with Barrett's esophagus”
We extend our gratitude to Dr. Li [1] and colleagues for their keen interest in our research, as expressed through their research letter which comments on our article, entitled “Association between endoscopic evidence of bile reflux and Barrett's esophagus: A large-scale case-control study” [2]. They conducted a meta-analysis including 6 cohort studies and concluded that bile reflux was associated with an increased risk of Barrett's esophagus, consistent with our study results. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 12, 2024 Category: Gastroenterology Authors: Yugo Iwaya Tags: Correspondence Source Type: research
Corrigendum to “Telemedicine in inflammatory bowel disease from its origin to the post pandemic golden age: A narrative review” [Digestive and Liver Disease, Volume 56, Issue 1, January 2024, Pages 1-6]
The authors regret that the author Amalia Di Petrillo's surname was tagged as Petrillo instead of Di Petrillo. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 8, 2024 Category: Gastroenterology Authors: Massimo Claudio Fantini, Erica Loddo, Amalia Di Petrillo, Sara Onali Tags: Corrigendum Source Type: research
Therapeutic endoscopy: Recent updates and future directions
The landscape of therapeutic endoscopy has undergone a remarkable evolution over the past few decades, carving out a niche that merges innovative technology with advanced clinical practice. As we venture further into the 21st century, the horizon of this field continues to expand, driven by rapid advancements in technology and a deeper understanding of gastrointestinal pathology. This review article aims to shed light on the recent advances and future trajectories of therapeutic endoscopy, focusing on pivotal areas such as third space endoscopy, endoscopic resection techniques, artificial endoscopy, endoscopic ultrasound (...
Source: Digestive and Liver Disease - April 6, 2024 Category: Gastroenterology Authors: Zaheer Nabi, D. Nageshwar Reddy Tags: Review Article Source Type: research
Preventing and managing cardiovascular events in patients with inflammatory bowel diseases treated with small-molecule drugs, an international Delphi consensus
Janus kinase (JAK) inhibitors and sphingosine 1 phosphate (S1P) receptor modulators are small molecule drugs (SMDs) approved for IBD treatment. Their use in clinical practice might be limited due to cardiovascular concerns. We aimed to provide guidance on risk assessment, monitoring, and management strategies, aiming to minimize potential cardiovascular risks of SMDs and to facilitate an adequate shared decision-making.A systematic literature search was conducted, and proposed statements were prepared. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 6, 2024 Category: Gastroenterology Authors: Pablo A. Olivera, Axel Dignass, Marla C. Dubinsky, Giovanni Peretto, Paulo G. Kotze, Iris Dotan, Taku Kobayashi, Subrata Ghosh, Fernando Magro, Jose Rocha Faria-Neto, Britta Siegmund, Silvio Danese, Laurent Peyrin-Biroulet Tags: Position Paper Source Type: research
