A case of refractory severe pyoderma gangrenosum successfully treated with upadacitinib

A 59-year-old woman affected by colonic Crohn's disease and perianal disease underwent colectomy and end ileostomy. Persistently active luminal disease was associated with severe pyoderma gangrenosum localized to the upper and lower limbs. Previous treatments with intravenous steroids and infliximab were not effective on pyoderma gangrenosum lesions. The image shows the evolution of a large and deep lesion localized on the right hand, after starting upadacitinib 45 mg once a day, with clear improvement and almost complete healing in 6 weeks of treatment (Fig.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Image of the Month Source Type: research