The role of diet in the pathophysiology and management of irritable bowel syndrome
AbstractIrritable bowel syndrome (IBS) is a chronic gastrointestinal (GI)  disorder that reportedly affects 5% to 20% of the world population. The etiology of IBS is not completely understood, but diet appears to play an important role in its pathophysiology. Asian diets differ considerably from those in Western countries, which might explain differences in the prevalenc e, sex, and clinical presentation seen between patients with IBS in Asian and Western countries. Dietary regimes such as a low-fermentable oligo-, di-, monosaccharides, and polyols (FODMAP) diet and the modified National Institute for Health and Care ...
Source: Indian Journal of Gastroenterology - March 5, 2021 Category: Gastroenterology Source Type: research

The relationship between dietary intakes and prevalence of irritable bowel syndrome in adolescent girls: A cross-sectional study
ConclusionsThe higher intake of caffeine was positively associated with IBS prevalence. Additionally, a negative association was seen between soluble dietary fiber intake and the chance of having IBS. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - March 5, 2021 Category: Gastroenterology Source Type: research

Toll-like receptor 4 (TLR4) antagonists as potential therapeutics for intestinal inflammation
AbstractGastrointestinal inflammation is a hallmark of highly prevalent disorders, including cancer treatment –induced mucositis and ulcerative colitis. These disorders cause debilitating symptoms, have a significant impact on quality of life, and are poorly managed. The activation of toll-like receptor 4 (TLR4) has been proposed to have a major influence on the inflammatory signalling pathways of the int estinal tract. Inhibition of TLR4 has been postulated as an effective way to treat intestinal inflammation. However, there are a limited number of studies looking into the potential of TLR4 antagonism as a therapeut...
Source: Indian Journal of Gastroenterology - March 5, 2021 Category: Gastroenterology Source Type: research

Editorial commentary on the Indian Journal of Gastroenterology January –February 2021
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - March 5, 2021 Category: Gastroenterology Source Type: research

Spontaneous giant biloma resulting from multifocal left hepatic duct perforation
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - March 5, 2021 Category: Gastroenterology Source Type: research

Idiopathic acute pancreatitis —A myth or reality? Role of endoscopic ultrasonography and magnetic resonance cholangiopancreatography in its diagnosis
ConclusionsEUS and MRCP are useful modalities in the etiological diagnosis of IAP and should be used in conjunction. EUS is better for establishing a possible biliary etiology and MRCP for an anatomical alteration in pancreatobiliary ducts. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - February 6, 2021 Category: Gastroenterology Source Type: research

Prognostic impact of incidentally detected hepatocellular carcinoma in explanted livers after living donor liver transplantation
ConclusionsIncidence of iHCC in explanted livers after LDLT is low and most patients have very early-stage tumors with excellent recurrence-free survival. Hence,  no specific post-transplant surveillance or treatment is necessary. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - February 6, 2021 Category: Gastroenterology Source Type: research

Acknowledgements
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 23, 2021 Category: Gastroenterology Source Type: research

Publication ethics: Role and responsibility of authors
This article discusses various unethical publication practices in research. Also, the role and responsibilities of authors have been discussed with the purpose of maintaining the credibility and objectivity of publication. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 22, 2021 Category: Gastroenterology Source Type: research

Neonatal and infantile cholestasis: An overlooked health burden with unmet needs
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 21, 2021 Category: Gastroenterology Source Type: research

Editorial commentary on the Indian Journal of Gastroenterology November-December 2020
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 18, 2021 Category: Gastroenterology Source Type: research

Diagnostic yield of endoscopic ultrasound –guided fine-needle aspiration of tubercular lymphadenitis using combination of cytology and Gene Xpert Mycobacterium tuberculosis /rifampicin (MTB/RIF) genes
AbstractDiagnostic yield of an automated molecular test, Gene XpertMycobacterium tuberculosis/rifampicin (MTB/RIF), was evaluated in this study to simultaneously detect the MTB gene and resistance to rifampicin (RIF) on cytology samples acquired via endoscopic ultrasound (EUS) –guided fine-needle aspiration (FNAC) in suspected tubercular lymphadenitis. Microscopy, cytology, Gene Xpert MTB/RIF assay data on Acid-fast bacillus (AFB), and traditional culture of lymph nodes were retrospectively analyzed. Thirty-one patients (median age 33.5 years, inter-quartile range [IQR ] 21–66, 18, 58% female) presented wi...
Source: Indian Journal of Gastroenterology - January 14, 2021 Category: Gastroenterology Source Type: research

Prevalence and risk factors of gastroesophageal reflux disease in a rural Indian population
ConclusionIn this rural Indian population, 10.7% had GERD and predominant rice eating, tobacco chewing, and carbonated soft drink intake were the risk factors. Psychological comorbidities were common. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 14, 2021 Category: Gastroenterology Source Type: research

Evaluation of esophageal motor function in patients with gastroesophageal reflux using multiple rapid swallows
AbstractMultiple rapid swallow (MRS) is a complementary test performed during high-resolution esophageal manometry (HREM). The present study was done to assess the MRS findings in patients with gastroesophageal reflux disease (GERD) who have normal peristalsis and minor motility disorders. This is a retrospective analysis from a prospectively maintained database of patients referred for HREM study to our center. The recorded  details included age, sex, symptoms with duration, and upper gastrointestinal endoscopy reports. HREM data included basal inspiratory and expiratory pressures, median integrated relaxation pressu...
Source: Indian Journal of Gastroenterology - January 13, 2021 Category: Gastroenterology Source Type: research

A novel homozygous frameshift variant in the ABCC2-gene in Dubin-Johnson syndrome may predispose to chronic liver disease
AbstractDubin-Johnson syndrome (DJS), an autosomal recessive disorder presenting with conjugated hyperbilirubinemia, is not associated with progression to chronic liver disease (CLD). Next-generation sequencing, application of bioinformatics pipeline, and segregation analysis were performed on 8 members of a consanguineous family with DJS and CLD. A novel variant, c.4406_4407delTA (p.Leu1469fs), in theABCC2-gene in a homozygous state was found to be associated with DJS and CLD in proband and afflicted family members. DJS may not be a benign entity and novel genetic  variants may be associated with progressive liver di...
Source: Indian Journal of Gastroenterology - January 11, 2021 Category: Gastroenterology Source Type: research

Gastric secretion in patients with caustic ingestion: A prospective study
This study was planned to determine the changes in gastric acid output in patients with caustic ingestion.MethodsIt was a prospective study done at a tertiary care center in northern India. Twenty consecutive patients in chronic phase of caustic ingestion were evaluated for the study. The gastric secretory function was estimated in the basal state and following pentagastrin stimulation. These results were compared with normal values for our laboratory.ResultsThe mean age of the included patients (n = 20) was 27.35 ± 2.96 years and 14 patients were male. Sixteen (80%) patients had a h...
Source: Indian Journal of Gastroenterology - January 8, 2021 Category: Gastroenterology Source Type: research

Cognitive dysfunction in ulcerative colitis patients in remission and its comparison with patients with irritable bowel syndrome and healthy controls
ConclusionPatients with IBD-UC in remission show impairments in cognitive functioning compared to the IBS and healthy control groups as assessed on cognitive function testing on MMSE, MoCA and mean peak latency of the p300 wave. This impairment in cognitive function is  unlikely to be due to premorbid levels of intellectual functioning and is likely to have impact on health-related quality of life. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 8, 2021 Category: Gastroenterology Source Type: research

Clofazimine-related duodenal pigmentation
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 8, 2021 Category: Gastroenterology Source Type: research

Esophageal graft versus host disease
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 8, 2021 Category: Gastroenterology Source Type: research

Role of therapeutic plasma exchange in acute liver failure due to yellow phosphorus poisoning
AbstractBackgroundTherapeutic plasma exchange (TPE) has been utilized in various liver disorders. There is limited data on the efficacy of TPE in patients with acute liver failure (ALF).MethodsStudy group consisted of patients who underwent TPE for ALF due to yellow phosphorous poisoning (YPP) between 2015 and 2019. Demographic data and biochemical parameters were recorded before and after TPE. Overall survival and transplant-free survival (based on King ’s College Hospital Criteria [KCHC]) were analyzed.ResultsForty-three patients underwent TPE for ALF due to YPP. Most of them were young males. Overall survival was ...
Source: Indian Journal of Gastroenterology - January 6, 2021 Category: Gastroenterology Source Type: research

Ischemic jejunal stricture in patients with extrahepatic  portal vein obstruction
We report three patients with EHPVO, who developed jejunal strictures due to MVT. They presented with symptoms of proximal bowel obstruction. Two of these patients had evidence of recurrent deep vein thrombosis (DVT), suggesting possibility of an underlying prothrombotic state. One of them had completely occluded bilateral iliac veins and inferior vena cava following DVT, 10 years ago. At the same time, he was identified as having a portal cavernoma. Contrast-enhanced computed tomography showed portal cavernoma together with MVT in all the patients. The thrombus was identified in the jejunal veins in two patients...
Source: Indian Journal of Gastroenterology - January 6, 2021 Category: Gastroenterology Source Type: research

Prevalence and risk factors for gastroesophageal reflux disease in the Indian population: A  meta-analysis and meta-regression study
AbstractBackgroundIndian population –based studies on the prevalence and risk factors for gastroesophageal reflux disease (GERD) are scanty, and a meta-analysis and a meta-regression of prevalence and risk factors based on the existing data have not yet been reported.MethodsA systematic review of all the available publications from India reporting data regarding prevalence and risk factors of GERD was performed. Heterogeneity was assessed usingI2 statistics. The meta-analysis was undertaken to measure the average proportion reported in the existing studies, and meta-regression models were used to explore the risk fac...
Source: Indian Journal of Gastroenterology - January 6, 2021 Category: Gastroenterology Source Type: research

Intra-biliary rupture of hepatic hydatid cyst: An uncommon presentation of a common disease
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 2, 2021 Category: Gastroenterology Source Type: research

Prevalence of celiac disease in Iranian patients with type 1 diabetes: A  systematic review and meta-analysis
AbstractPatients with type 1 diabetes mellitus (T1DM) are at high risk for celiac disease (CD) due to the common genetic background and interaction between environmental and immunological factors. The purpose of this systematic review and meta-analysis was to estimate the prevalence of CD  among Iranian patients with type 1 diabetes. The search for articles was conducted using the following keywords: “celiac disease,” “celiac,” “coeliac disease,” “diabetes,” “Iran,” and all other possible combinations of these terms. The following databases were searched from...
Source: Indian Journal of Gastroenterology - December 1, 2020 Category: Gastroenterology Source Type: research

Splenic stiffness and platelet count to predict varices needing treatment in pediatric extrahepatic  portal vein obstruction
ConclusionSSM is higher in EHPVO bleeders but SSM and platelet counts are unreliable to predict VNT in pediatric EHPVO. Surveillance endoscopies may be needed in all pediatric EHPVO until better screening strategies are available.Trial registrationNot applicable (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 24, 2020 Category: Gastroenterology Source Type: research

Hepatosplenic cat scratch disease: The usefulness of liver biopsy
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 24, 2020 Category: Gastroenterology Source Type: research

Outcome of hepatitis C –related liver transplantation in direct-acting antiviral era
ConclusionIn the DAA era, HCV as an indication for LT has decreased and patients have less severe disease at transplantation. There is a trend towards better patient survival. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 24, 2020 Category: Gastroenterology Source Type: research

Prevalence, overlap, and risk factors for Rome IV functional gastrointestinal disorders among college students in northern India
AbstractBackground/PurposeThere is scarcity of data on prevalence, overlap, and risk factors for functional gastrointestinal disorders (FGID) by Rome IV criteria. We evaluated these factors among medical, nursing, and humanities students.MethodsRome IV Diagnostic Questionnaire (for all FGIDs), Rome III questionnaire (for irritable bowel syndrome [IBS], functional diarrhea [FDr], and functional constipation [FC]), and questionnaires assessing demography, physical activity, anxiety, and depression were used.ResultsA total of 1309 college students were included (medical 425, nursing 390, humanities 494; mean age 20.5  ...
Source: Indian Journal of Gastroenterology - November 23, 2020 Category: Gastroenterology Source Type: research

Indian Journal of Gastroenterology September-October 2020
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 23, 2020 Category: Gastroenterology Source Type: research

The effect of a low-nickel diet and nickel sensitization on gastroesophageal reflux disease: A pilot study
ConclusionsA low-nickel diet improves GERD symptoms, but responsiveness to a low-nickel diet does not correlate with epicutaneous patch testing to nickel.Trial registrationClinicalTrials.gov number: NCT03720756 (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 21, 2020 Category: Gastroenterology Source Type: research

The prevalence of uninvestigated dyspepsia and the association of physical exercise with quality of life of uninvestigated dyspepsia patients in Indonesia: An internet-based survey
AbstractBackgroundEpidemiological data on the prevalence of uninvestigated dyspepsia (UD) and its impact on the health-related quality of life (HRQOL) in Indonesian population are still lacking. There is no study investigating the association between exercise and the HRQOL in UD patients. We aimed to investigate the prevalence of UD and its association with physical exercise, and its impact on HRQOL in Indonesian patients with UD.MethodsThis was a population-based, cross-sectional study, conducted using an internet-based questionnaire which was randomly distributed throughout Indonesia using the social media. The questionn...
Source: Indian Journal of Gastroenterology - November 21, 2020 Category: Gastroenterology Source Type: research

Association between anti-acid therapies and advanced fibrosis in type 2 diabetics with biopsy-proven non-alcoholic fatty liver disease
AbstractBackgrounds and AimsData on associations of antacid therapies with advanced fibrosis (AF) in patients with non-alcoholic fatty liver disease (NAFLD) are limited. We aimed to assess the association of histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) with AF in NAFLD patients with underlying type 2 diabetes (T2D).MethodsWe retrospectively reviewed patient ’s charts with T2D who had a liver biopsy for suspected NAFLD. Fibrosis stages were determined as F0–F4, AF being F3–4. Laboratory data and use of various medications within 24 months of liver biopsies were used for t...
Source: Indian Journal of Gastroenterology - November 21, 2020 Category: Gastroenterology Source Type: research

Monitoring photographic proof of cecal intubation: A closed-loop audit of best practice colonoscopy
AbstractGold standard colonoscopy in the UK demands a 90% cecal intubation (CI) rate. Endoscopists must provide photographic evidence of CI, which can include images of the terminal ileum, appendix orifice, anastomosis or ileocecal valve. Whilst photographic proof of intubation should be obtained for all complete colonoscopies, this is not routinely audited. Three hundred and ninety-six complete colonoscopies were analyzed, 200 in an initial audit, and 196 in a second audit. Photos taken during colonoscopy were reviewed for evidence of successful CI, as well as whether these photographs had been marked as “proof of i...
Source: Indian Journal of Gastroenterology - November 21, 2020 Category: Gastroenterology Source Type: research

Second correction to: Diet and inflammatory bowel disease: The Asian Working Group guidelines
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 21, 2020 Category: Gastroenterology Source Type: research

Utility of bowel ultrasound in assessing disease activity in Crohn ’s disease
ConclusionLoss of stratification, BWT,  and Doppler activity in the bowel wall correlate with endoscopic and clinical disease activity in CD. GIUS is a sensitive modality in assessing disease activity in CD.  (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 17, 2020 Category: Gastroenterology Source Type: research

Endoscopic mucosal resection for early esophageal carcinoma is effective and safe but necessitates continued surveillance
ConclusionEMR is effective and safe for the management of early EC. The risk of cancer recurrence, albeit small, warrants surveillance. Complete eradication of Barrett ’s should be attempted in all patients after EMR of AC. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 17, 2020 Category: Gastroenterology Source Type: research

In vitro analysis of gallstone formation in the presence of bacteria
AbstractAimIn our previous study, we have isolated different genera of bacteria from gallstones and this intrigued us to study their role in gallstone formation. The isolates exhibited certain biliary activities like urease activity, slime production, and β-glucuronidase production. We aimed to investigate the role of these factors in the formation of gallstone in in vitro conditions at a supersaturated concentration of cholesterol.MethodologyTo mimic bile in in vitro state, Brilliant Green Bile Broth (BGBB) media having a composition similar to human bile was used. Four different experimental sets were prepared, each...
Source: Indian Journal of Gastroenterology - November 17, 2020 Category: Gastroenterology Source Type: research

Single-balloon enteroscopy in management of small-bowel disorders
ConclusionSBE is a safe and effective procedure in diagnosing and treating small-bowel diseases. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 16, 2020 Category: Gastroenterology Source Type: research

Spectrum of mutations in genes associated with familial colorectal cancer syndrome (MLH1, MSH2, PMS2, MSH6, and APC): A not so common hereditary cancer syndrome in Indian population
We present here our experience and spectrum of pathogenic variants observed in this patient cohort and review on published studies describing molecular profile of Indian patients with CRC syndromes. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 16, 2020 Category: Gastroenterology Source Type: research

Correction to: Clinical efficacy of infliximab level and anti-infliximab antibody measurement in patients with inflammatory bowel disease: An audit
The published online version contain error for the author's name “Kiran Peddi” was incorrectly presented as “Kiran Peddy” (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 16, 2020 Category: Gastroenterology Source Type: research

Prevalence of cirrhotic cardiomyopathy and its relationship  with serum pro-brain natriuretic peptide, hepatorenal syndrome, spontaneous bacterial peritonitis, and mortality
ConclusionThe study showed that diastolic dysfunction was  highly prevalent (56.6% of the study population) in cirrhosis patients. QTc interval and pro-BNP were also significantly raised. Also, complications of cirrhosis like HRS, spontaneous bacterial peritonitis, and hepatic encephalopathy were more common in the cirrhotic cardiomyopathy group. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 13, 2020 Category: Gastroenterology Source Type: research

Development of integrated neonatal cholestasis card for early recognition and referral of neonatal cholestasis
ConclusionThe integrated NC card proposes to recognize neonatal cholestasis at an early stage irrespective of etiology. It is a major step towards public health benefit both at the community as well as physicians ’ levels to enable early detection and timely referral and management. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 11, 2020 Category: Gastroenterology Source Type: research

Argon plasma coagulation —an effective treatment for solitary rectal ulcer syndrome: A single-center experience from western India
ConclusionsAPC with conventional therapy is effective in controlling bleeding and healing in SRUS refractory to conventional treatment. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 11, 2020 Category: Gastroenterology Source Type: research

Short-term mortality in patients with cirrhosis of the liver and acute kidney injury: A prospective observational study
ConclusionDevelopment of AKI as defined by the International Ascites Club in cirrhosis confers high short-term mortality. Jaundice, HE, AKI stage, creatinine at enrollment, bilirubin, CTP, and MELD score were the predictors of mortality.Bullet points of the study highlightsWhat is already known?• Renal failure is a common and severe complication of cirrhosis.• Serum creatinine is the most practical biomarker of renal function but it has many limitations in cirrhotic patients.• Creatinine kinetics–based definition of acute kidney injury (AKI) was proposed by the International Ascites Club.What is new in...
Source: Indian Journal of Gastroenterology - November 11, 2020 Category: Gastroenterology Source Type: research

Respiratory function and comfort levels in three different defecatory simulation postures in the elderly
ConclusionThe arm-supported, forward-leaning defecation posture provides a high degree of freedom in the abdomen due to proper forward-leaning, while the upper limb support improves the mobility of the upper thorax, thus ensuring high lung volume. In addition, the increased stability provides a comfortable feeling. Therefore, we conclude that the arm-supported, forward-leaning position is more effective for defecation than the general defecation position. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 11, 2020 Category: Gastroenterology Source Type: research

Hemoclips during motorized spiral enteroscopy —A unique case
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 7, 2020 Category: Gastroenterology Source Type: research

IgG4-related sclerosing cholangitis — A great mimicker
AbstractIgG4-related disease (IgG4 RD) is a multisystem disorder characterized by tumefactive (mass forming) lesions, storiform fibrosis, and IgG4-positive plasma cell infiltration. IgG4 sclerosing cholangitis (IgG4 SC) is the biliary manifestation of IgG4 RD, often in association with autoimmune pancreatitis (AIP). Here, we report two patients with IgG4-related cholangitis mimicking primary sclerosing cholangitis. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 6, 2020 Category: Gastroenterology Source Type: research

Effect of successive endoscopic procedures in polyp and adenoma detection rates: Too early is not always too good
ConclusionTheoretical endoscopist ’s fatigue due to cumulative performance of endoscopies does not diminish colonoscopy quality. Both PDR and ADR seem to improve after endoscopist’s cumulative rounds of performed endoscopies. This could be due to a “warm-up” effect. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - November 4, 2020 Category: Gastroenterology Source Type: research

Basics of meta-analysis
AbstractMeta-analysis is an approach to formally, systematically and quantitatively analyze multiple existing research studies and to synthesize new research findings based upon the existing data. Until the late 1970s, meta-analyses were not regularly reported in the medical literature, but since then there has been an exponential growth of meta-analyses and they are now among the most frequently cited form of research. A properly performed systematic review and meta-analysis is a very important tool in evidence-based medicine and a good understanding of the steps involved in doing a systematic review and meta-analysis is ...
Source: Indian Journal of Gastroenterology - November 4, 2020 Category: Gastroenterology Source Type: research

Gastrocutaneous fistula secondary to drainage tube penetration in a child: Closure using argon plasma coagulation
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - October 31, 2020 Category: Gastroenterology Source Type: research