Role of lactulose for prophylaxis against hepatic encephalopathy in cirrhotic patients with upper gastrointestinal bleeding: A randomized trial
ConclusionFive-day lactulose is ineffective as prophylaxis against HE in cirrhotic patients with AUGIB. Unnecessary  treatment with laxatives should be avoided in these patients.Trial registrationClinical trial registry number TCTR20200526003 (retrospectively registered) (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - June 15, 2021 Category: Gastroenterology Source Type: research

Small bowel enteroscopy: Indian experience
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - June 2, 2021 Category: Gastroenterology Source Type: research

Microscopy of the starry sky
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - May 29, 2021 Category: Gastroenterology Source Type: research

Eosinophilic gastroenteritis: Clinical characteristics and management
AbstractThere is paucity of published data related to eosinophilic gastroenteritis (EGE). We aimed to study the clinical characteristics, management, and follow-up of EGE.  From March 2014 to December 2018, patients with gastrointestinal (GI) symptoms suspected to have EGE were investigated. This is a retrospective study. Complete blood count, upper GI endoscopy (UGIE), and biopsy were done. Contrast-enhanced computed tomography (CECT) abdomen was done when intestina l obstruction was suspected. Laparoscopic small bowel resection or stricturoplasty and full-thickness biopsy were obtained. EGE was diagnosed if the biop...
Source: Indian Journal of Gastroenterology - May 28, 2021 Category: Gastroenterology Source Type: research

Diet and nutrition in the management of inflammatory bowel disease
AbstractThe role of diet and its manipulation in the management of inflammatory bowel disease (IBD) is gradually acquiring central stage. Certain dietary factors have been identified as putative triggers in IBD as some other factors are found to be protective. The dietary manipulation as part of comprehensive IBD care should be done by the clinician in conjunction with a skilled dietitian. Nutritional deficiencies are common in patients with IBD and can have long-term effects on disease course and quality of life in these patients. So, early identification and correction of these deficiencies along with proper nutritional ...
Source: Indian Journal of Gastroenterology - May 26, 2021 Category: Gastroenterology Source Type: research

Effect of moderate aerobic exercises on symptoms of functional dyspepsia
The objective was to study the effects of moderate aerobic exercise on symptoms of FD and to compare the effect of conventional treatment alone vs. exercise plus conventional treatment.MethodsOut of 112 patients, 72 were randomly divided into controls (conventional treatment;  n=36) and experimental (aerobic exercise for 30 min per session, 5 times a week for 6 weeks with conventional treatment;n=36) groups. Both the  groups were assessed on day 1 and at the end of 6 weeks, using Glasgow Dyspepsia Severity Score (GDSS), Depression Anxiety Stress Scales-42 (DASS-42), and visual analogue scale (VAS).ResultsPre-trea...
Source: Indian Journal of Gastroenterology - May 26, 2021 Category: Gastroenterology Source Type: research

Computed tomography features predictive of intra-abdominal hypertension in acute necrotizing pancreatitis:  A prospective study
ConclusionPresence of RBS, moderate-gross ascites, and pancreatic necrosis of>  50% on CECT can predict the presence of IAH in these groups of patients. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - May 21, 2021 Category: Gastroenterology Source Type: research

Comparison of the efficacy of growth factor collagen and antibiotic collagen on colon anastomosis in   experimental animals with peritonitis
Conclusion FGF-C and AB-C may have potential utility in anastomosis healing, especially in those susceptible to infection due to anastomosis leak. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - May 21, 2021 Category: Gastroenterology Source Type: research

Living donor liver transplantation for hepatocellular carcinoma in Indian patients — Is the scenario different?
ConclusionPatients with HCC in India present late for liver transplant. Most patients have some form of decompensation before they undergo LT. In selected patients, overall survival was comparable with other indications for LDLT with acceptable recurrence rates. RETREAT score was best to predict recurrence. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - May 21, 2021 Category: Gastroenterology Source Type: research

Chicago Classification of esophageal motility disorders: Past, present, and future
AbstractThe Chicago Classification (CC) is a dynamic, evolving classification scheme created by a diverse group of international esophageal experts. Its application has transformed the way esophageal motor data are used to define motility disorders, each iteration seeking to advance, simplify, and standardize the way clinicians worldwide diagnose esophageal dysmotility. The most recent update, CC version 4.0 (CCv4.0), emphasizes the importance of clinical context and distinguishes clinically relevant, conclusive manometric diagnoses from irrelevant manometric observations. Future iterations of CC may refine the classificat...
Source: Indian Journal of Gastroenterology - May 19, 2021 Category: Gastroenterology Source Type: research

Editorial commentary on the Indian Journal of Gastroenterology – May–June 2021
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - May 19, 2021 Category: Gastroenterology Source Type: research

Prevalence of liver injury in 445 patients with Corona Virus Disease-19-Single-centre experience from southern India
ConclusionLiver test abnormalities were widespread in patients with COVID-19. Most of the patients had borderline or mild transaminase elevation. Despite only mild changes, patients with abnormal LFT were more likely to be symptomatic and had more severe disease and mortality. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - May 15, 2021 Category: Gastroenterology Source Type: research

Evaluating the efficacy of nitazoxanide in uncomplicated amebic liver abscess
ConclusionsThis study shows equivalent efficacy of nitazoxanide in uncomplicated amebic liver abscess as compared to metronidazole, with better tolerability and advantage of simultaneous luminal clearance, thus reducing chances of recurrence.Trial registrationCTRI/2019/01/017249 (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - May 15, 2021 Category: Gastroenterology Source Type: research

Baveno criteria perform better than expanded Baveno and Rete Sicilia Selezione Terapia –Hepatitis C virus criteria for predicting varices needing treatment
ConclusionBaveno criteria are useful to avoid screening endoscopies in patients with cirrhosis of viral etiologies. In contrast, although expanded Baveno criteria and RESIST-HCV criteria spare more endoscopies, a high missed VNT rate limits their applicability. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - May 15, 2021 Category: Gastroenterology Source Type: research

Current practices in the management of corrosive ingestion in children: A questionnaire-based survey and recommendations
ConclusionCorrosive ingestion mostly affects 2 –5-year olds and is accidental in majority. It can be potentially prevented by proper storage and labelling of corrosives. An algorithm for management is proposed. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - May 15, 2021 Category: Gastroenterology Source Type: research

Management of scope-induced type I duodenal perforations: Over-the-scope clip versus surgery
ConclusionsOTSC is a feasible and better option in type I duodenal perforations with a shorter hospital stay. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - May 11, 2021 Category: Gastroenterology Source Type: research

Serum C-reactive protein and neutrophil-to-lymphocyte ratio as predictors of survival in cirrhotic patients with systemic inflammatory response syndrome and bacterial infection
AbstractBackgroundCirrhotic patients are prone to infections due to underlying immune dysfunction  in them. We aimed to study the role of inflammatory markers, serum C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR), in predicting infection, blood culture positivity, and short-term (1 month) mortality in hospitalized cirrhotic patients.MethodsThis  prospective study was done over a period of 14 months (October 2017 to November 2018). Patient data included age, gender, etiology of cirrhosis, reason for admission, and comorbidity. Laboratory tests included blood chemistry and blood ce...
Source: Indian Journal of Gastroenterology - May 11, 2021 Category: Gastroenterology Source Type: research

Editorial commentary on the Indian Journal of Gastroenterology  - March-April 2021
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - May 7, 2021 Category: Gastroenterology Source Type: research

Innovative rescue therapy for ulcer bleeding after band ligation: New ENDOLOOP/clips/grasping forceps technique
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - April 19, 2021 Category: Gastroenterology Source Type: research

Abdominal cocoon —An uncommon cause of intestinal obstruction
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - April 16, 2021 Category: Gastroenterology Source Type: research

Low prevalence of gastroesophageal reflux symptoms in vegetarians
This study compares the prevalence of GERS in vegetarians with non-vegetarian controls from the general population. Frequency and severity of GERS (heartburn and/or acid regurgitation) were assessed with a self-administrated questionnaire.ResultsWithin 1 year, any GERS were experienced by 19 of 100 (19%) vegetarians and by 98 of 250 (39.2%) non-vegetarian controls (p
Source: Indian Journal of Gastroenterology - April 12, 2021 Category: Gastroenterology Source Type: research

Diagnostic utility of alarm features in predicting malignancy in patients with dyspeptic symptoms
ConclusionsPatients of age group 40 to 49 years with dyspeptic alarm symptoms (predominant weight loss) need prompt endoscopy to screen for malignancy. The alarm features are inexpensive screening tools, found to be useful in India, and should be utilized in countries with similar healthcare conditions and disease epidemiology. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - April 8, 2021 Category: Gastroenterology Source Type: research

Efficacy of polyethylene glycol 3350 as compared to lactulose in treatment of ROME IV criteria –defined pediatric functional constipation: A randomized controlled trial
AbstractBackground and AimsFunctional constipation is a common childhood problem, with a prevalence of approximately 3% worldwide. The aim of the study was to compare the efficacy of polyethylene glycol (PEG) 3350 and lactulose in the treatment of pediatric functional constipation.MethodsA total of 100 subjects with functional constipation were enrolled and centrally randomized to receive PEG 3350 (0.7 –1.5 mg/kg/day) or lactulose (0.7–2.0 g/kg/day).ResultsThere was a significant increase in median (min, max) stool frequency within 1 week in the PEG 3350 group as compared to the lactulose group (1 [0, 3] to 8 [...
Source: Indian Journal of Gastroenterology - April 8, 2021 Category: Gastroenterology Source Type: research

miR-222 regulates cell growth, apoptosis, and autophagy of interstitial cells of Cajal isolated from slow transit constipation rats by targeting c-kit
ConclusionmiR-222 induces apoptosis and excessive autophagy of ICC and may serve as potential biomarker for ICC loss in STC. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - April 1, 2021 Category: Gastroenterology Source Type: research

Efficacy of combining pentoxiphylline and vitamin E versus vitamin E alone in non-alcoholic steatohepatitis — A randomized pilot study
ConclusionsThese data show greater efficacy of a combination of PTX and VE in achieving fibrosis regression compared to VE alone with better metabolic homeostasis and amelioration of the pro-inflammatory status.Trial registrationClinical Trials Registry no. NCT01384578 (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - March 27, 2021 Category: Gastroenterology Source Type: research

Post liver transplant complications of Budd-Chiari syndrome
ConclusionsWhole-organ LT from deceased donors in patients with BCS had comparable outcomes with LT due to other causes of end-stage liver disease. In most instances, these patients should receive lifelong anticoagulation. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - March 20, 2021 Category: Gastroenterology Source Type: research

Micro-organic basis of functional gastrointestinal (GI) disorders: Role of microRNAs in GI pacemaking cells
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - March 19, 2021 Category: Gastroenterology Source Type: research

The role of diet in the pathophysiology and management of irritable bowel syndrome
AbstractIrritable bowel syndrome (IBS) is a chronic gastrointestinal (GI)  disorder that reportedly affects 5% to 20% of the world population. The etiology of IBS is not completely understood, but diet appears to play an important role in its pathophysiology. Asian diets differ considerably from those in Western countries, which might explain differences in the prevalenc e, sex, and clinical presentation seen between patients with IBS in Asian and Western countries. Dietary regimes such as a low-fermentable oligo-, di-, monosaccharides, and polyols (FODMAP) diet and the modified National Institute for Health and Care ...
Source: Indian Journal of Gastroenterology - March 5, 2021 Category: Gastroenterology Source Type: research

The relationship between dietary intakes and prevalence of irritable bowel syndrome in adolescent girls: A cross-sectional study
ConclusionsThe higher intake of caffeine was positively associated with IBS prevalence. Additionally, a negative association was seen between soluble dietary fiber intake and the chance of having IBS. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - March 5, 2021 Category: Gastroenterology Source Type: research

Toll-like receptor 4 (TLR4) antagonists as potential therapeutics for intestinal inflammation
AbstractGastrointestinal inflammation is a hallmark of highly prevalent disorders, including cancer treatment –induced mucositis and ulcerative colitis. These disorders cause debilitating symptoms, have a significant impact on quality of life, and are poorly managed. The activation of toll-like receptor 4 (TLR4) has been proposed to have a major influence on the inflammatory signalling pathways of the int estinal tract. Inhibition of TLR4 has been postulated as an effective way to treat intestinal inflammation. However, there are a limited number of studies looking into the potential of TLR4 antagonism as a therapeut...
Source: Indian Journal of Gastroenterology - March 5, 2021 Category: Gastroenterology Source Type: research

Editorial commentary on the Indian Journal of Gastroenterology January –February 2021
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - March 5, 2021 Category: Gastroenterology Source Type: research

Spontaneous giant biloma resulting from multifocal left hepatic duct perforation
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - March 5, 2021 Category: Gastroenterology Source Type: research

Idiopathic acute pancreatitis —A myth or reality? Role of endoscopic ultrasonography and magnetic resonance cholangiopancreatography in its diagnosis
ConclusionsEUS and MRCP are useful modalities in the etiological diagnosis of IAP and should be used in conjunction. EUS is better for establishing a possible biliary etiology and MRCP for an anatomical alteration in pancreatobiliary ducts. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - February 6, 2021 Category: Gastroenterology Source Type: research

Prognostic impact of incidentally detected hepatocellular carcinoma in explanted livers after living donor liver transplantation
ConclusionsIncidence of iHCC in explanted livers after LDLT is low and most patients have very early-stage tumors with excellent recurrence-free survival. Hence,  no specific post-transplant surveillance or treatment is necessary. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - February 6, 2021 Category: Gastroenterology Source Type: research

Acknowledgements
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 23, 2021 Category: Gastroenterology Source Type: research

Publication ethics: Role and responsibility of authors
This article discusses various unethical publication practices in research. Also, the role and responsibilities of authors have been discussed with the purpose of maintaining the credibility and objectivity of publication. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 22, 2021 Category: Gastroenterology Source Type: research

Neonatal and infantile cholestasis: An overlooked health burden with unmet needs
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 21, 2021 Category: Gastroenterology Source Type: research

Editorial commentary on the Indian Journal of Gastroenterology November-December 2020
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 18, 2021 Category: Gastroenterology Source Type: research

Diagnostic yield of endoscopic ultrasound –guided fine-needle aspiration of tubercular lymphadenitis using combination of cytology and Gene Xpert Mycobacterium tuberculosis /rifampicin (MTB/RIF) genes
AbstractDiagnostic yield of an automated molecular test, Gene XpertMycobacterium tuberculosis/rifampicin (MTB/RIF), was evaluated in this study to simultaneously detect the MTB gene and resistance to rifampicin (RIF) on cytology samples acquired via endoscopic ultrasound (EUS) –guided fine-needle aspiration (FNAC) in suspected tubercular lymphadenitis. Microscopy, cytology, Gene Xpert MTB/RIF assay data on Acid-fast bacillus (AFB), and traditional culture of lymph nodes were retrospectively analyzed. Thirty-one patients (median age 33.5 years, inter-quartile range [IQR ] 21–66, 18, 58% female) presented wi...
Source: Indian Journal of Gastroenterology - January 14, 2021 Category: Gastroenterology Source Type: research

Prevalence and risk factors of gastroesophageal reflux disease in a rural Indian population
ConclusionIn this rural Indian population, 10.7% had GERD and predominant rice eating, tobacco chewing, and carbonated soft drink intake were the risk factors. Psychological comorbidities were common. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 14, 2021 Category: Gastroenterology Source Type: research

Evaluation of esophageal motor function in patients with gastroesophageal reflux using multiple rapid swallows
AbstractMultiple rapid swallow (MRS) is a complementary test performed during high-resolution esophageal manometry (HREM). The present study was done to assess the MRS findings in patients with gastroesophageal reflux disease (GERD) who have normal peristalsis and minor motility disorders. This is a retrospective analysis from a prospectively maintained database of patients referred for HREM study to our center. The recorded  details included age, sex, symptoms with duration, and upper gastrointestinal endoscopy reports. HREM data included basal inspiratory and expiratory pressures, median integrated relaxation pressu...
Source: Indian Journal of Gastroenterology - January 13, 2021 Category: Gastroenterology Source Type: research

A novel homozygous frameshift variant in the ABCC2-gene in Dubin-Johnson syndrome may predispose to chronic liver disease
AbstractDubin-Johnson syndrome (DJS), an autosomal recessive disorder presenting with conjugated hyperbilirubinemia, is not associated with progression to chronic liver disease (CLD). Next-generation sequencing, application of bioinformatics pipeline, and segregation analysis were performed on 8 members of a consanguineous family with DJS and CLD. A novel variant, c.4406_4407delTA (p.Leu1469fs), in theABCC2-gene in a homozygous state was found to be associated with DJS and CLD in proband and afflicted family members. DJS may not be a benign entity and novel genetic  variants may be associated with progressive liver di...
Source: Indian Journal of Gastroenterology - January 11, 2021 Category: Gastroenterology Source Type: research

Gastric secretion in patients with caustic ingestion: A prospective study
This study was planned to determine the changes in gastric acid output in patients with caustic ingestion.MethodsIt was a prospective study done at a tertiary care center in northern India. Twenty consecutive patients in chronic phase of caustic ingestion were evaluated for the study. The gastric secretory function was estimated in the basal state and following pentagastrin stimulation. These results were compared with normal values for our laboratory.ResultsThe mean age of the included patients (n = 20) was 27.35 ± 2.96 years and 14 patients were male. Sixteen (80%) patients had a h...
Source: Indian Journal of Gastroenterology - January 8, 2021 Category: Gastroenterology Source Type: research

Cognitive dysfunction in ulcerative colitis patients in remission and its comparison with patients with irritable bowel syndrome and healthy controls
ConclusionPatients with IBD-UC in remission show impairments in cognitive functioning compared to the IBS and healthy control groups as assessed on cognitive function testing on MMSE, MoCA and mean peak latency of the p300 wave. This impairment in cognitive function is  unlikely to be due to premorbid levels of intellectual functioning and is likely to have impact on health-related quality of life. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 8, 2021 Category: Gastroenterology Source Type: research

Clofazimine-related duodenal pigmentation
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 8, 2021 Category: Gastroenterology Source Type: research

Esophageal graft versus host disease
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 8, 2021 Category: Gastroenterology Source Type: research

Role of therapeutic plasma exchange in acute liver failure due to yellow phosphorus poisoning
AbstractBackgroundTherapeutic plasma exchange (TPE) has been utilized in various liver disorders. There is limited data on the efficacy of TPE in patients with acute liver failure (ALF).MethodsStudy group consisted of patients who underwent TPE for ALF due to yellow phosphorous poisoning (YPP) between 2015 and 2019. Demographic data and biochemical parameters were recorded before and after TPE. Overall survival and transplant-free survival (based on King ’s College Hospital Criteria [KCHC]) were analyzed.ResultsForty-three patients underwent TPE for ALF due to YPP. Most of them were young males. Overall survival was ...
Source: Indian Journal of Gastroenterology - January 6, 2021 Category: Gastroenterology Source Type: research

Ischemic jejunal stricture in patients with extrahepatic  portal vein obstruction
We report three patients with EHPVO, who developed jejunal strictures due to MVT. They presented with symptoms of proximal bowel obstruction. Two of these patients had evidence of recurrent deep vein thrombosis (DVT), suggesting possibility of an underlying prothrombotic state. One of them had completely occluded bilateral iliac veins and inferior vena cava following DVT, 10 years ago. At the same time, he was identified as having a portal cavernoma. Contrast-enhanced computed tomography showed portal cavernoma together with MVT in all the patients. The thrombus was identified in the jejunal veins in two patients...
Source: Indian Journal of Gastroenterology - January 6, 2021 Category: Gastroenterology Source Type: research

Prevalence and risk factors for gastroesophageal reflux disease in the Indian population: A  meta-analysis and meta-regression study
AbstractBackgroundIndian population –based studies on the prevalence and risk factors for gastroesophageal reflux disease (GERD) are scanty, and a meta-analysis and a meta-regression of prevalence and risk factors based on the existing data have not yet been reported.MethodsA systematic review of all the available publications from India reporting data regarding prevalence and risk factors of GERD was performed. Heterogeneity was assessed usingI2 statistics. The meta-analysis was undertaken to measure the average proportion reported in the existing studies, and meta-regression models were used to explore the risk fac...
Source: Indian Journal of Gastroenterology - January 6, 2021 Category: Gastroenterology Source Type: research

Intra-biliary rupture of hepatic hydatid cyst: An uncommon presentation of a common disease
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 2, 2021 Category: Gastroenterology Source Type: research