Study of Association of Chromosomal Region 1Q21-23 with Rheumatoid Arthritis and Their Correlation with Severity of Disease
CONCLUSION: Bigger cohort studies will allow better genomic elucidation of clinically defined intermediate phenotypes evaluated in RA patients by virtue of the autoimmune origin of the disease and its diverse symptoms in patients. Genetic-molecular studies can be a milestone for adopting effective personalized treatment for such progressively debilitating diseases. How to cite this article: Gauri LA, Meena MK, Singh U, et al. Study of Association of Chromosomal Region 1Q21-23 with Rheumatoid Arthritis and Their Correlation with Severity of Disease. J Assoc Physicians India 2023;71(9):28-32.PMID:38700298 | DOI:10.59556/japi...
Source: Journal of the Association of Physicians of India - May 3, 2024 Category: General Medicine Authors: Liyakat Ali Gauri Manoj Kumar Meena Ummed Singh Nikita Manoj Nadeem Liyakat Ramratan Yadav Ambreen Liyakat None Nisha Source Type: research
Using machine learning algorithms based on patient admission laboratory parameters to predict adverse outcomes in COVID-19 patients
In this study, we present a novel predictive model centered on routine clinical laboratory test data to swiftly forecast patient survival outcomes upon admission. Our model integrates feature selection algorithms and binary classification algorithms, optimizing algorithmic selection through meticulous parameter control. Notably, we developed an algorithm coupling Lasso and SVM methodologies, achieving a remarkable area under the ROC curve of 0.9277 with the use of merely 8 clinical laboratory parameters collected upon admission. Our primary contribution lies in the utilization of straightforward laboratory parameters for p...
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Yuchen Fu Xuejing Xu Juan Du Taihong Huang Jiping Shi Guanghao Song Qing Gu Han Shen Sen Wang Source Type: research
Prospective Deep Learning-based Quantitative Assessment of Coronary Plaque by CT Angiography Compared with Intravascular Ultrasound
CONCLUSIONS: Artificial intelligence enabled CCTA quantification and characterization of atherosclerosis demonstrated strong agreement with IVUS reference standard measurements. This tool may prove effective for accurate evaluation of coronary atherosclerotic burden and cardiovascular risk assessment.[ClinicalTrails.gov identifier: NCT05138289].PMID:38700097 | DOI:10.1093/ehjci/jeae115 (Source: Atherosclerosis)
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Jagat Narula Thomas D Stuckey Gaku Nakazawa Amir Ahmadi Mitsuaki Matsumura Kersten Petersen Saba Mirza Nicholas Ng Sarah Mullen Michiel Schaap Jonathan Leipsic Campbell Rogers Charles A Taylor Harout Yacoub Himanshu Gupta Hitoshi Matsuo Sarah Rinehart Aki Source Type: research
Evaluation of the Pneumonia Panel on laboratory samples from an Italian pediatric center: results from a monocentric study
New Microbiol. 2024 May;47(1):33-37.ABSTRACTLower respiratory tract infections (LRTI) are still burdened by considerable morbidity and mortality. Rapid and appropriate treatment imply knowledge of the underlying causative pathogen; while it is tempting to offer broad spectrum antibiotics, Antimicrobial Stewardship Practices invite a judicious use of the latter, especially when bacteria are not the cause. However, the epidemiology shifts to multidrug resistant (MDR) pathogens that require optimization of molecules in order to provide optimal treatment. Novel methods requiring direct sample result testing such as the Biofire...
Source: New Microbiologica - May 3, 2024 Category: Microbiology Authors: Cristiana de Luca Emanuela Gallo Gabriella Tripepi Ornella Leone Source Type: research
Jugular Foramen Paragangliomas
Adv Tech Stand Neurosurg. 2024;49:201-229. doi: 10.1007/978-3-031-42398-7_10.ABSTRACTParagangliomas are the most common tumors at jugular foramen and pose a great surgical challenge. Careful clinical history and physical examination must be performed to adequately evaluate neurological deficits and its chronologic evolution, also to delineate an overview of the patient performance status. Complete imaging evaluation including MRI and CT scans should be performed, and angiography is a must to depict tumor blood supply and sigmoid sinus/internal jugular vein patency. Screening for multifocal paragangliomas is advisable, with...
Source: Advances and Technical Standards in Neurosurgery - May 3, 2024 Category: Neurosurgery Authors: Guilherme H W Ceccato Luis A B Borba Source Type: research
Exploring Appropriate Reference Intervals and Clinical Decision Limits for Glucose-6-Phosphate Dehydrogenase Activity in Individuals From Guangzhou, China
CONCLUSIONS: Collectively, our findings contribute to a more accurate evaluation of G6PD-activity levels within the local population and provide valuable insights for clinical decision-making. Specifically, identifying threshold values for G6PD variants and hemolysis risk enables improved prediction and management of G6PD deficiency, ultimately enhancing patient care and treatment outcomes.PMID:38699793 | DOI:10.3343/alm.2023.0477 (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - May 3, 2024 Category: Laboratory Medicine Authors: Zhenyi Huang Ziyan Li Yating Li Yunshan Cao Suping Zhong Jinlu Liu Zhiqian Lin Lijuan Lin Yanping Fang Jing Zeng Zhaoying Su Huibin Li Jianfen Liang Biqing Zhu Zipei Lin Yongxin Huang Xuexi Yang Lingxiao Jiang Source Type: research
Health status and public health needs in a Togolese child health care centre modelled after the Dutch system
CONCLUSION: A large group of children in need of prevention and early treatment were detected, informed and treated by the centre. Further research is needed to confirm if this strategy can improve children's health in Sub-Saharan Africa. Our data are available for further research.PMID:38700227 | DOI:10.1080/03014460.2024.2342529 (Source: Annals of Human Biology)
Source: Annals of Human Biology - May 3, 2024 Category: Biology Authors: Paula van Dommelen C écile Schat-Savy Arjan Huizing Symone Detmar Leonhard A Bakker Paul H Verkerk Source Type: research
Supinoxin blocks Small Cell Lung Cancer Progression by Inhibiting Mitochondrial Respiration through the RNA Helicase DDX5
Res Sq [Preprint]. 2024 Apr 15:rs.3.rs-4169007. doi: 10.21203/rs.3.rs-4169007/v1.ABSTRACTDDX5 is a DEAD-box RNA helicase that is overexpressed and implicated in progression of several cancers 1-4. One of these is small cell lung cancer (SCLC). Our laboratory has demonstrated that the RNA helicase DDX5 is essential for the invasive growth of SCLC and mitochondrial respiration 5. SCLC is an extremely lethal, recalcitrant tumor 6,7, causing 250,000 deaths annually worldwide 8 and currently lacking effective treatments 9,10. Supinoxin (RX 5902), a compound having anti-cancer activity 11, is a known target of phosphor-DDX5 12,1...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Elizabeth Tran Subhadeep Das Matthew Russon Maria Zea Zheng Xing Sandra Torregrosa-Allen Heidi Cervantes Bennett Elzey Haley Harper Source Type: research
Combined Effects of Glenohumeral Mobilization, Stretching, and Thoracic Manipulation on Shoulder Internal Rotation Range of Motion
DISCUSSION: Both GH posterior mobilizations and sleeper stretches improved IR and horizontal adduction PROM in a single session. The addition of thoracic manipulation prior to local shoulder interventions resulted in smaller gains of both IR and horizontal adduction ROM.LEVEL OF EVIDENCE: Level 2.PMID:38699673 | PMC:PMC11065457 | DOI:10.26603/001c.95040 (Source: Physical Therapy)
Source: Physical Therapy - May 3, 2024 Category: Physiotherapy Authors: Brian T Swanson Marissa Hagenbruch Bernardine Lapaan Kirill Skipalskiy Source Type: research
Predictors of mortality, mortality rates, and clinical characteristics of adult patients with extreme hyperferritinemia
DiscussionExtreme hyperferritinemia is associated with high short-term mortality. Ferritin can be used as a marker of poor prognosis, particularly among patients with infection and malignancy. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 3, 2024 Category: General Medicine Source Type: research
Impact of COVID-19 pandemic on care of maintenance hemodialysis patients: a multicenter study
ConclusionThe COVID-19 pandemic and its related lockdown negatively affected multiple aspects of dialysis patient care. Continued access of optimum care in dialysis patients should be a priority in any future mass events. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - May 3, 2024 Category: Urology & Nephrology Source Type: research
Biochemical risk factors and outcomes of acute promyelocytic leukemia patients with thrombotic events: a matched pair analysis
AbstractAcute promyelocytic leukemia (APL) stands out as a distinctive form of acute leukemia, exhibiting a higher occurrence of thrombotic events when contrasted with other leukemia subtypes. Since thrombosis is a relatively rare but unfavorable condition with poor prognostic implications, it is crucial to determine the risk factors for thrombotic events in APL(thrombosis in large venous or arterial from onset to differentiation therapy in 30d). We performed a retrospective study involving 950 APL patients between January 2000 and October 2022, from which 123 were excluded by younger than 16 years of age, 95 were exclud...
Source: Journal of Thrombosis and Thrombolysis - May 3, 2024 Category: Hematology Source Type: research
What do we know about Aquafilling tissue filler? – A systematic review
ConclusionsOver time, Aquafilling injection can potentially result in a variety of complications. It triggers inflammation and prophylactic removal should be considered. MRI and USG are recommended in the diagnostic process. Elevated CRP, WBC, or ESR indicate the presence of comorbidity or advanced gel infection. The recommended treatment is radical surgery. There is not enough information available in the literature about reconstruction, especially regarding immediate reconstruction. Antibiotics should be administered according to the antibiogram, with ciprofloxacin and clindamycin being considered if empirical treatment ...
Source: European Journal of Plastic Surgery - May 3, 2024 Category: Cosmetic Surgery Source Type: research
Technologies for design-build-test-learn automation and computational modelling across the synthetic biology workflow: a review
AbstractMotivated by the need to parameterize and functionalize dynamic, multiscale simulations, as well as bridge the gap between advancing in silico and laboratory Synthetic Biology practices, this work evaluated and contextualized Synthetic Biology data standards and conversion, modelling and simulation methods, genetic design and optimization, software platforms, machine learning, assembly planning, automated modelling, combinatorial methods, biological circuit design and laboratory automation. This review also discusses technologies related to domain specific languages, libraries and APIs, databases, whole cell models...
Source: Network Modeling Analysis in Health Informatics and Bioinformatics - May 3, 2024 Category: Bioinformatics Source Type: research
Elemental composition and contaminants of saffron from different origins and geographical discrimination using chemometrics
. (Source: Food Additives and Contaminants Part A)
Source: Food Additives and Contaminants Part A - May 3, 2024 Category: Food Science Authors: Leena KumariS. Swarupa Tripathya CSIR-National Physical Laboratory, Dr. K.S. Krishnan Marg, New Delhi, Indiab ICAR-CIPHET (Central Institute of Post-Harvest Engineering and Technology), Ludhiana, Indiac Academy of Scientific and Innovative Research (AcSIR Source Type: research
