TWiV 664: TWiV is for the dogs
On this mid-week edition, does it matter that SARS-CoV-2 is mutating, seasonal coronavirus immunity is short-lived, another bogus claim that the virus was produced in a laboratory (it came from Nature), and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Coronavirus is mutating (Nature) Seasonal CoV immunity is short (Nat Med) Sorry, no link to the fake science document! Letters read on TWiV 664 Timestamps by Jolene. Thanks! In...
Source: This Week in Virology - MP3 Edition - September 17, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 656: See, it can be done!
Daniel Griffin provides a clinical report on COVID-19, surgeons Lisa Smith and David Bruce detail how they have helped their Chattanooga community during the pandemic, then we discuss racial and ethnic disparities among COVID-19 cases, no more premarket review of laboratory developed tests by FDA; and emergency use authorization of convalescent plasma is on hold. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Daniel Griffin, Lisa A. Smith, and W. David Bruce Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Racial and ethnic di...
Source: This Week in Virology - MP3 Edition - August 23, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 651: FDA rules with Denise Esposito
Daniel Griffin provides a clinical report on COVID-19, then former FDA Chief of Staff to the Commissioner Denise Esposito joins us to explain the challenges in approving vaccines, antiviral drugs, and diagnostic tests during a pandemic, followed by answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Denise Esposito Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Template for at-home, OTC diagnostic tests (FDA) Postdoctoral position...
Source: This Week in Virology - MP3 Edition - August 9, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 645: Lions and tigers and zookeepers (oh my)
Daniel Griffin provides a clinical report on COVID-19, followed by a review of the State Department document on the Wuhan BSL-4 laboratory, the report on infection of tigers and lions in the Bronx Zoo, and, answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode State Dept. memo on Wuhan BSL-4 lab (pdf) Biosafety levels (Wikipedia) Inside a BSL-4 (TWiV) From people to panthers (bioRxiv) Letter...
Source: This Week in Virology - MP3 Edition - July 26, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 628: Physical distance for COVID-19
Vincent and Rich discuss the SARS-CoV-2 D614G amino acid change in the spike glyprotein, duration of infectious virus shedding from patients, virus transmission among hamsters infected in the laboratory, and tackle listener email. Hosts: Vincent Racaniello and Rich Condit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Austin TX key indicators for staging D614 amino acid change (Scripps) Virus shedding in hospitalized patients (medRxiv) Hamster SARS-CoV-2 model (Nature) COVID-19 host genetic initiative Image credit Letters read on...
Source: This Week in Virology - MP3 Edition - June 18, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 627: Singapore National Centre for Infectious Diseases
Vincent visits the National Centre for Infectious Diseases and speaks with Executive Director Leo Yee-Sin and Consultant Nancy Tee about the main hub for both clinical treatment of infectious diseases and outbreak management in Singapore. Host: Vincent Racaniello Guests: Leo Yee-Sin and Nancy Tee Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode National Centre for Infectious Diseases National Public Health Laboratory Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv (Source: This Wee...
Source: This Week in Virology - MP3 Edition - June 17, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 626: Ralph Baric and fancy ferrets
Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin, Chuck Knirsch, and Ralph Baric Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Mouse-adapted SARS-CoV-2 model (bioRxiv) SARS-CoV-2 mRNA vaccine (bioRxiv) ASM resources for #shutdownstem President Obama on sustaining momentum for change (...
Source: This Week in Virology - MP3 Edition - June 14, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 619: Recombination led to emergence of SARS-CoV-2
Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Raul Rabadan Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Rabadan Laboratory Understanding Coronavirus (Amazon) Topological Data Analysis for Genomics and Evolution (Amazon) Recombination and mutation shaped SARS-CoV-2 (bioRxiv) Bat CoV with cleavage site insertion (Curr Biol) Timestamps by Jolene. Thanks! Intro music i...
Source: This Week in Virology - MP3 Edition - May 27, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

ASFH Implanting an Artificial Retina – part 2
Guest: Daniel Palanker, PhD Professor, Department of Ophthalmology Director, Hansen Experimental Physics Laboratory Stanford University Stanford, CA (Source: As Seen From Here)
Source: As Seen From Here - May 15, 2020 Category: Opthalmology Authors: JYoungMD at gmail.com Source Type: podcasts

ASFH Implanting an Artificial Retina – part 1
Guest: Daniel Palanker, PhD Professor, Department of Ophthalmology Director, Hansen Experimental Physics Laboratory Stanford University Stanford, CA (Source: As Seen From Here)
Source: As Seen From Here - May 1, 2020 Category: Opthalmology Authors: JYoungMD at gmail.com Source Type: podcasts

TWiV 602: Coronavirus immunology with Stanley Perlman
Stanley Perlman joins TWiV to discuss immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, including prospects for a vaccine. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Stanley Perlman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Perlman Laboratory An Iowa Caucus of Viruses (TWiV 538) Anti-SARS-CoV spike IgG and acute lung injury (JCI Insight) T cell responses to respiratory CoV (Immunol Res) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenk...
Source: This Week in Virology - MP3 Edition - April 16, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 588: Coronavirus update - Save the pangolin!
The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode WHO CoV sitreps Epidemiology of COVID-19 (China CDC) COVID-19 incubation period (J...
Source: This Week in Virology - MP3 Edition - February 23, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 583: Galveston virus hunters
Vincent and Rich travel to Galveston National Laboratory to speak with Jim LeDuc, Tom Ksiazek, and Bob Tesch about their long careers as virus hunters. Hosts: Vincent Racaniello and Rich Condit Guests: Jim LeDuc, Tom Ksiazek, and Bob Tesh Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - January 19, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 555: Fidelity and the single cell
From ASM Microbe 2019, Vincent, Brianne and Calvin meet up with Craig Cameron to discuss his career and his work exploring RNA-dependent RNA synthesis and single cell virology. Hosts: Vincent Racaniello, Brianne Barker, and Calvin Yeager Guest: Craig Cameron Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Cameron laboratory Curioscity podcast Ribavirin is an RNA virus mutagen (Nat Med) RNA virus error catastrophe: test using ribavirin (PNAS) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology qu...
Source: This Week in Virology - MP3 Edition - July 7, 2019 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

Creating chimeras for organ transplants and how bats switch between their eyes and ears on the wing
Researchers have been making animal embryos from two different species, so-called “chimeras,” for years, by introducing stem cells from one species into a very early embryo of another species. The ultimate goal is to coax the foreign cells into forming an organ for transplantation. But questions abound: Can evolutionarily distant animals, like pigs and humans, be mixed togeth er to produce such organs? Or could species closely related to us, like chimps and macaques, stand in for tests with human cells? Staff Writer Kelly Servick joins host Sarah Crespi to discuss the research, the regulations, and the growing ...
Source: Science Magazine Podcast - June 27, 2019 Category: Science Authors: Science Tags: Scientific Community Source Type: podcasts

Creating chimeras for organ transplants and how bats switch between their eyes and ears on the wing
Researchers have been making animal embryos from two different species, so-called “chimeras,” for years, by introducing stem cells from one species into a very early embryo of another species. The ultimate goal is to coax the foreign cells into forming an organ for transplantation. But questions abound: Can evolutionarily distant animals, like pigs and humans, be mixed togeth er to produce such organs? Or could species closely related to us, like chimps and macaques, stand in for tests with human cells? Staff Writer Kelly Servick joins host Sarah Crespi to discuss the research, the regulations, and the growing ...
Source: Science Magazine Podcast - June 27, 2019 Category: Science Authors: Science Tags: Scientific Community Source Type: podcasts

"Next Wave" -- The Discovery Files
An NSF-funded wave research laboratory sets the stage to study the structural integrity of buildings under severe weather conditions, which could help engineers devise better building codes and standards to protect future coastal structures. (Source: The Discovery Files)
Source: The Discovery Files - June 13, 2019 Category: Science Authors: National Science Foundation Source Type: podcasts

TWiV 531: Circ du RNA
Patrick Moore returns to TWiV to discuss the discovery from the Chang-Moore laboratory of circular RNAs in cells infected with herpesviruses. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Guest: Patrick Moore Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Cancer virology at Pitt Alice Huang’s DI particles (PubMed) Circular DNA tumor viruses make ci...
Source: This Week in Virology - MP3 Edition - January 20, 2019 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 530: Quiet please!
Steve Goff returns to TWiV to discuss the work of his laboratory on how retroviral genomes are silenced in infected cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Guest: Steve Goff Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! 🎼 They’ll histone you when you start to transcribe, And they’ll histone you just for tryin’ to get by, So be careful when you uncoat your genome, ‘Cause everybody must histone. Links for this episode Please take the TWiV listener survey ASV 2019 European C...
Source: This Week in Virology - MP3 Edition - January 13, 2019 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 525: The A Bee Cs of bee viruses
Michelle Flenniken joins TWiV to talk about honeybees and the work of her laboratory on honeybee viruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Michelle Flenniken Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MSU Pollinator Health Center Honeybee antiviral defenses (Sci Rep) The buzz about honeybee viruses (PLoS Path) Recently identified bee viruses (Curr Op Insect Sci) Videos on honey bee researchat MSU, honey bee pathogens, honey bee pathogen detection (YouTube) Timestamps...
Source: This Week in Virology - MP3 Edition - December 16, 2018 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 520: This old mouse
The TWiVidae review universal influenza vaccines that are in clinical trials, and discovery of an atypical parvovirus that causes chronic kidney disease in middle aged, immunocompromised laboratory mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit,  Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode PhD and postdoctoral programs at Dept of Microbiology, Icahn School of Medicine at Mount Sinai MSc program Molecular Biology and Pathology of Viruses, Univ Colleg...
Source: This Week in Virology - MP3 Edition - November 18, 2018 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

A big increase in monkey research and an overhaul for the metric system
A new report suggests a big increase in the use of monkeys in laboratory experiments in the United States in 2017. Online News Editor David Grimm joins host Sarah Crespi to discuss which areas of research are experiencing this rise and the possible reasons behind it. Also this week, host Meagan Cantwell talks with staff writer Adrian Cho about a final push to affix the metric system’s measures to physical constants instead of physical objects. That means the perfectly formed 1-kilogram cylinder known as Le Grand K is no more; it also means that the meter, th e ampere, and other units of measure are now derived usin...
Source: Science Magazine Podcast - November 8, 2018 Category: Science Authors: Science Tags: Scientific Community Source Type: podcasts

A big increase in monkey research and an overhaul for the metric system
A new report suggests a big increase in the use of monkeys in laboratory experiments in the United States in 2017. Online News Editor David Grimm joins host Sarah Crespi to discuss which areas of research are experiencing this rise and the possible reasons behind it. Also this week, host Meagan Cantwell talks with staff writer Adrian Cho about a final push to affix the metric system’s measures to physical constants instead of physical objects. That means the perfectly formed 1-kilogram cylinder known as Le Grand K is no more; it also means that the meter, th e ampere, and other units of measure are now derived usin...
Source: Science Magazine Podcast - November 8, 2018 Category: Science Authors: Science Tags: Scientific Community Source Type: podcasts

Targeting Vulnerabilities Arising from Dysregulated Histone Demethylase Function in Kidney Cancer
Abhishek A. Chakraborty Instructor in Medicine Department of Medical Oncology Laboratory of William Kaelin Dana-Farber Cancer Institute Harvard Medical School discusses Targeting ... Author: kidneycancer Added: 11/06/2018 (Source: Oncology Tube)
Source: Oncology Tube - November 6, 2018 Category: Cancer & Oncology Source Type: podcasts

Using Mutational Signatures To Tailor New Treatments
Thomas Helleday, Phd, Helleday Laboratory, Discusses Using Mutational Signatures To Tailor New Treatments. At ESMO Oncology Conference - Munich, Germany On October 19, 2018. Author: Cancer-News Added: 10/29/2018 (Source: Oncology Tube)
Source: Oncology Tube - October 29, 2018 Category: Cancer & Oncology Source Type: podcasts

Personlized therapy for MDS: Advancements and the future
Torsten Haferlach, MD, PhD, of the Munich Leukaemia laboratory, Munich, Germany, highlights the rapidly expanding field of molecular diagnostics, moving us towards personalized medicine for patients w... Author: VJHemOnc Added: 09/28/2018 (Source: Oncology Tube)
Source: Oncology Tube - September 28, 2018 Category: Cancer & Oncology Source Type: podcasts

"Mudicinal Properties" -- The Discovery Files
Arizona State University and Mayo Clinic researchers have found that one type of clay, Oregon blue clay, may help fight disease-causing bacteria in wounds, including treatment-resistant bacteria. In laboratory tests, the researchers found that the clay has antibacterial effects against bacteria such as Escherichia coli and Staphylococcus aureus, including strains such as carbapenem-resistant Enterobacteriaceae and methicillin-resistant Staphylococcus aureus (MRSA). (Source: The Discovery Files)
Source: The Discovery Files - September 6, 2018 Category: Science Authors: National Science Foundation Source Type: podcasts

TWiV 508: Bioweapon
Jens returns to present a brief history of bioweapons, with a focus on the program in the Soviet Union, the largest ever undertaken, and his experience working in the decommissioned Soviet bioweapons laboratory known as Vector. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Jens Kuhn Become a patron of TWiV! Links for this episode Russia's Bioweapons Labs (Nature) Medical Aspects of Biological Warfare The Soviet Biological Weapons Program by Leitenberg, Zilinskas, Kuhn Biological Threats in the 21st Century by Lentzos Bioterrorism and Biocrimes by W....
Source: This Week in Virology - MP3 Edition - August 26, 2018 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

Challenges for access to CAR T-cell therapy
Speaking from the 2018 European School of Hematology (ESH) Clinical Updates on Acute Leukemias, held in Budapest, Hungary, Torsten Haferlach, MD, of MLL Munich Leukemia Laboratory, Munich, Germany sta... Author: VJHemOnc Added: 08/16/2018 (Source: Oncology Tube)
Source: Oncology Tube - August 16, 2018 Category: Cancer & Oncology Source Type: podcasts

Advice about ALL treatment in the clinical setting
In this interview, Torsten Haferlach, MD, of MLL Munich Leukemia Laboratory, Munich, Germany, reflects on the differences between the treatment of acute lymphoblastic leukemia (ALL) in clinical practi... Author: VJHemOnc Added: 08/16/2018 (Source: Oncology Tube)
Source: Oncology Tube - August 16, 2018 Category: Cancer & Oncology Source Type: podcasts

Important stratifications for the treatment of ALL
Speaking from the 2018 European School of Hematology (ESH) Clinical Updates on Acute Leukemias, held in Budapest, Hungary, Torsten Haferlach, MD, of MLL Munich Leukemia Laboratory, Munich, Germany, st... Author: VJHemOnc Added: 08/16/2018 (Source: Oncology Tube)
Source: Oncology Tube - August 16, 2018 Category: Cancer & Oncology Source Type: podcasts

ALL diagnostics: challenges and considerations
In this interview, Torsten Haferlach, MD, of MLL Munich Leukemia Laboratory, Munich, Germany, speaks about the difficulties in diagnosing and treating particular subsets of acute lymphoblastic leukemi... Author: VJHemOnc Added: 08/16/2018 (Source: Oncology Tube)
Source: Oncology Tube - August 16, 2018 Category: Cancer & Oncology Source Type: podcasts

TWiV 506: A Cafeteria full of jelly rolls
The TWiVniks explain how the three-dimensional structure of the giant Cafeteria roenbergensis virus suggests a new mode of assembly, and the apparent elimination of dengue fever in an Australian city by release of mosquitoes harboring Wolbachia. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference New DRC Ebola strains distinct (Outbreak News) Immunizations for new DRC Ebola outbreak (The Scientist) Structure of Cafeteria roenbergensis virus (Sci Rep) Chuan (River) Xiao laborat...
Source: This Week in Virology - MP3 Edition - August 12, 2018 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 503: The greening of TWiV
Vincent, Rich and Kathy travel to ASV 2018 at the University of Maryland to speak with Svetlana Folimonova and Anne Simon about their work on viruses that infect plants. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Svetlana Folimonova and Anne Simon Become a patron of TWiV! Links for this episode Simon laboratory Folimonova laboratory CTV superinfection exclusion (Virol) 3'-CITEs in viral genome (J Virol) Video of this episode (YouTube) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - July 22, 2018 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

The role of TP53 in CLL
In this interview, Christopher Fox, MBChB(Hons), MRCP, FRCPath, of Nottingham University Hospitals NHS Trust, Nottingham, UK, provides an overview of the role of TP53 mutations in both the laboratory ... Author: VJHemOnc Added: 06/26/2018 (Source: Oncology Tube)
Source: Oncology Tube - June 26, 2018 Category: Cancer & Oncology Source Type: podcasts

Pathology and laboratory medicine
Kenneth Fleming and John Nkengasong discuss the importance of pathology services, as part ofThe Lancet’s Series on pathology and laboratory medicine in low-income and middle-income countries. (Source: Listen to The Lancet)
Source: Listen to The Lancet - March 15, 2018 Category: General Medicine Authors: The Lancet Source Type: podcasts

MABp1: 'Clever' New Antibody Targeting Colorectal Cancer
A trial using MABp1, an antibody targeting interleukin 1 alpha, showed some benefit for patients with advanced colorectal cancer, but Dr Kerr thinks the clinical endpoint used was a'little soft.'(Source: Medscape Pathology and Laboratory Medicine Podcast)
Source: Medscape Pathology and Laboratory Medicine Podcast - February 14, 2018 Category: Laboratory Medicine Authors: Medscape Source Type: podcasts

Next Steps for Immunotherapies, Cell Therapies in Oncology
At ESMO 2017, Drs Zimmermann, Svane, and Coukos discuss successes and setbacks in immuno-oncology. (Source: Medscape Pathology and Laboratory Medicine Podcast)
Source: Medscape Pathology and Laboratory Medicine Podcast - February 9, 2018 Category: Laboratory Medicine Authors: Medscape Source Type: podcasts

Dr. Peter Lucas discusses clinical trial testing
Dr. Peter Lucas, Director of Laboratory Services & Principal Investigator at NSABP, discusses clinical trial testing. Author: NSABP_Foundation Added: 01/12/2018 (Source: Oncology Tube)
Source: Oncology Tube - January 12, 2018 Category: Cancer & Oncology Source Type: podcasts

Wisely Choosing the Right Lab Tests
Dr Lundberg discussed the American Society for Clinical Pathology's list of 20 lab tests you should carefully consider before ordering. (Source: Medscape Pathology and Laboratory Medicine Podcast)
Source: Medscape Pathology and Laboratory Medicine Podcast - December 11, 2017 Category: Laboratory Medicine Authors: Medscape Source Type: podcasts

"Cancer Advance" -- The Discovery Files
Scientists have developed an effective new strategy for treating cancer, which has wiped out the disease to near completion in cellular cultures in the laboratory. The treatment works by controlling chromatin, a group of macromolecules -- including DNA, RNA and proteins -- that houses genetic information within cells and determines which genes get suppressed or expressed. (Source: The Discovery Files)
Source: The Discovery Files - November 29, 2017 Category: Science Authors: National Science Foundation Source Type: podcasts

TWiV 467: Jon and Ted's Excellent Adventure
Jon and Teddy Yewdell join the TWiV team to talk about their careers, their research, and the problems with biomedical research. Hosts: Vincent Racaniello, Alan Dove,and Rich Condit Guest: Jon Yewdell and Teddy Yewdell Become a patron of TWiV! Links for this episode Jon Yewdell laboratory Chaudhuri laboratory Truth Wins by Jon Yewdell (epub or mobi download) Noncoding RNAs and class switch recombination (Int Imm) Translating DRiPs (J Leuk Biol) Lamprey VLRP response to influenza virus (eLife) The Biomedical Research Crisis (TWiV 208) This episode is brought to you by the Department...
Source: This Week in Virology - MP3 Edition - November 12, 2017 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 465: Theodora the explorer
Theodora Hatziioannou joins the TWiV team to discuss a macaque model for AIDS, and how a cell protein that blocks HIV-1 infection interacts with double-stranded RNA. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Theodora Hatziioannou Become a patron of TWiV! Links for this episode ASU-UofA Joint Virology Symposium Laboratory of Retrovirology, Rockefeller University HIV-1-induced AIDS in monkeys (Science) APOBEC3H bound to duplex RNA (Nat Comm) Center for HIV RNA studies Image: Two molecules of APOBEC3H bound to dsRNA This...
Source: This Week in Virology - MP3 Edition - October 29, 2017 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 462: Splicing RNA with Phillip A. Sharp
Vincent speaks with 1993 Nobel Laureate Phillip A. Sharp about his career and his seminal discovery of RNA splicing in mammalian cells, which changed our understanding of gene structure. Hosts: Vincent Racaniello Guest: Phillip A. Sharp Become a patron of TWiV! Links for this episode Meet the Microbiologist Sharp Laboratory Spliced segments of adenovirus late mRNA (PNAS) Video of this interview (YouTube) This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chem...
Source: This Week in Virology - MP3 Edition - October 7, 2017 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 460: Penn, a great sandbox for science
Vincent travels to the University of Pennsylvania and speaks with virologists Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss about their careers and their research. Host: Vincent Racaniello Guests: Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss Become a patron of TWiV! Links for this episode Cohen Laboratory Hensley Laboratory Lopez Laboratory Weiss Laboratory This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological D...
Source: This Week in Virology - MP3 Edition - September 24, 2017 Category: Virology Authors: Vincent Racaniello Source Type: podcasts