Hepatocyte-specific METTL3 ablation by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and postnatal lethality
In this study, we explored the potential reasons why hepatocyte-specific METTL3 homozygous disruption by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and then postnatal lethality.MAIN METHODS: Mice with hepatocyte-specific METTL3 knockout were generated by simultaneously crossing METTL3fl/fl mice with Alb-iCre mice (GPT; Strain No. T003814) purchased from the GemPharmatech Co., Ltd., (Nanjing, China) or with Alb-Cre mice (JAX; Strain No. 003574) obtained from The Jackson Laboratory, followed by combined-phenotype analysis. The publicly available RNA-sequencing data deposited in ...
Source: Aging - April 24, 2024 Category: Biomedical Science Authors: Shihao Huang Yingchun Li Bingjie Wang Zhihao Zhou Yonglong Li Lingjun Shen Jinge Cong Liuxin Han Xudong Xiang Jiawei Xia Danhua He Zhanlin Zhao Ying Zhou Qiwen Li Guanqi Dai Hanzhang Shen Taoyan Lin Aibing Wu Junshuang Jia Dong Xiao Jing Li Wentao Zhao Xi Source Type: research
Iron deficiency in astrocytes alters cellular status and impacts on oligodendrocyte differentiation
J Neurosci Res. 2024 Apr;102(4):e25334. doi: 10.1002/jnr.25334.ABSTRACTIron deficiency (ID) has been shown to affect central nervous system (CNS) development and induce hypomyelination. Previous work from our laboratory in a gestational ID model showed that both oligodendrocyte (OLG) and astrocyte (AST) maturation was impaired. To explore the contribution of AST iron to the myelination process, we generated an in vitro ID model by silencing divalent metal transporter 1 (DMT1) in AST (siDMT1 AST) or treating AST with Fe3+ chelator deferoxamine (DFX; DFX AST). siDMT1 AST showed no changes in proliferation but remained immatu...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Mar ía Silvina Marcora Vanesa Soledad Mattera Pilar Go ñi Florencia Aybar Jorge Daniel Correale Juana Maria Pasquini Source Type: research
Patients hospitalized with active tuberculosis and Covid-19 coinfection: A matched case-control from the Brazilian Covid-19 Registry
An Acad Bras Cienc. 2024 Apr 22;96(1):e20230791. doi: 10.1590/0001-3765202420230791. eCollection 2024.ABSTRACTAlthough control of Covid-19 has improved, the virus continues to cause infections, such as tuberculosis, that is still endemic in many countries, representing a scenario of coinfection. To compare Covid-19 clinical manifestations and outcomes between patients with active tuberculosis infection and matched controls. This is a matched case-control study based on data from the Brazilian Covid-19 Registry, in hospitalized patients aged 18 or over with laboratory confirmed Covid-19 from March 1, 2020, to March 31, 2022...
Source: An Acad Bras Cienc - April 24, 2024 Category: Science Authors: Rafael L R Carvalho Gabriella G Aguiar Jessica F B Moreira Daniella N Pereira Val éria Maria Augusto Alexandre V Schwarzbold Carolina C Matos Danyelle R A Rios Fel ício R Costa Fernando Anschau Jos é Miguel Chatkin Karen B Ruschel Marcelo Carneiro Neim Source Type: research
Cascade ring expansion reactions for the synthesis of medium-sized rings and macrocycles
Chem Commun (Camb). 2024 Apr 24. doi: 10.1039/d4cc01303d. Online ahead of print.ABSTRACTThis Feature Article discusses recent advances in the development of cascade ring expansion reactions for the synthesis of medium-sized rings and macrocycles. Cascade ring expansion reactions have much potential for use in the synthesis of biologically important medium-sized rings and macrocycles, most notably as they don't require high dilution conditions, which are commonly used in established end-to-end macrocyclisation methods. Operation by cascade ring expansion method can allow large ring products to be accessed via rearrangements...
Source: Chemical Communications - April 24, 2024 Category: Chemistry Authors: Jack M Wootton Jerry K F Tam William P Unsworth Source Type: research
Crown Ether Electrolyte Induced Li2O2 Amorphization for Low Polarization and Long Lifespan Li-O2 batteries
Angew Chem Int Ed Engl. 2024 Apr 24:e202403521. doi: 10.1002/anie.202403521. Online ahead of print.ABSTRACTLithium-oxygen batteries possess an extremely high theoretical energy density, rendering them a prime candidate for next-generation secondary batteries. However, they still face multiple problems such as huge charge polarization and poor cycle life, which lay a significant gap between laboratory research and commercial applications. In this work, we adapt 15-crown-5 ether (C15) as solvent to regulate the generation of discharge products in lithium-oxygen batteries. The coronal structure endows C15 with strong affinity...
Source: Angewandte Chemie - April 24, 2024 Category: Chemistry Authors: Meng Li Jiaxin Wu Zichang You Zhongqin Dai Yuanfan Gu Lei Shi Meifen Wu Zhaoyin Wen Source Type: research
A real ‐time signal processing software package for the electrophysiology laboratory
ConclusionWe have developed and demonstrated the feasibility of a readily scalable and open-access Python-based plug in to an electroanatomic mapping system (EnSiteX) to allow real-time processing and display of electrogram (EGM) based information for the procedural electrophysiologist to view intraprocedurally in the electrophysiology laboratory. The availability, to the clinician, of traditional and novel EGM-based metrics at the time of intervention, such as atrial fibrillation ablation, allows for key mechanistic insights into critical unresolved questions regarding arrhythmia mechanism. (Source: Journal of Cardiovascu...
Source: Journal of Cardiovascular Electrophysiology - April 24, 2024 Category: Cardiology Authors: Kathryn D. Tiver,
Campbell Strong,
Dhani Dharmaprani,
Darius Chapman,
Evan Jenkins,
Sobhan Salari Shahrbabaki,
Anand N. Ganesan Tags: BRIEF COMMUNICATION Source Type: research
Randomized investigation of the MitraClip device in heart failure: Design and rationale of the RESHAPE ‐HF2 trial design
ConclusionsThe RESHAPE-HF2 trial will provide sound evidence on the MitraClip device and its effects in HF patients with FMR. The recruitment was recently completed with 506 randomized patients. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - April 24, 2024 Category: Cardiology Authors: Stefan D. Anker,
Tim Friede,
Ralph Stephan von Bardeleben,
Javed Butler,
Kaneez Fatima,
Monika Diek,
Jutta Heinrich,
Gerd Hasenfu ß,
Wolfgang Schillinger,
Piotr Ponikowski Tags: Study Design Source Type: research
Clinical Pathologic Conference Case #6: Oral and Cutaneous Findings in a 14-year-old Female
A 14-year-old female with a history of Kawasaki disease was referred to a university oral medicine clinic by her orthodontist due to swollen, hemorrhagic gingiva and tooth mobility. Scurvy was suspected by the patient's nurse practitioner and confirmed by a measure of ascorbic acid in plasma of less than 5 μmol per liter (0.1 mg per deciliter; reference range, 23 to 114 μmol per liter [0.4 to 2.0 mg per deciliter]). Laboratory testing also revealed vitamin D deficiency with a measured 25-hydroxyvitamin D level of less than 23.3 ng per milliliter (50 nmol per liter; reference range 32.0-100.0 ng per milliliter). (Source: ...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 24, 2024 Category: ENT & OMF Authors: Sarah Glass, Mark Mintline Source Type: research
Antibiotics daptomycin interacts with S protein of SARS-CoV-2 to promote cell invasion of Omicron (B1.1.529) pseudovirus
Volume 15, Issue 1, December 2024 . (Source: Virulence)
Source: Virulence - April 24, 2024 Category: Virology Authors: Xu CaoLan HuangMin TangYue LiangXinpeng LiuHuijin HouShufang LiangDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China Source Type: research
Co-immunization with DNA vaccines encoding yidR and IL-17 augments host immune response against Klebsiella pneumoniae infection in mouse model
Volume 15, Issue 1, December 2024 . (Source: Virulence)
Source: Virulence - April 24, 2024 Category: Virology Authors: Zheng LvXuan ZhangKelei ZhaoLianming DuXinrong WangYiwen ChuTing Huanga Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, School of pharmacy, Chengdu University, Chengdu, Chinab Institute for Advanced Study, Chengdu University, Ch Source Type: research
Phenolic compounds from Limonium densiflorum: a multifaceted approach to antioxidant, anti-inflammatory, anticancer, and anti-influenza activities
. (Source: International Journal of Environmental Health Research)
Source: International Journal of Environmental Health Research - April 24, 2024 Category: Environmental Health Authors: Faten MediniRiadh KsouriKamel MsaadaJean Legaulta Laboratory of Aromatic and Medicinal Plants (LPAM), Center of Biotechnology of Borj-Cedria, Hammam-Lif, Tunisiab LASEVE Laboratory, Quebec University at Chicoutimi, 555 Boulvard of the University, Chicouti Source Type: research
Chemical structures, biological activities, and biosynthetic analysis of secondary metabolites of the Diatrypaceae family: A comprehensive review
. (Source: Mycology)
Source: Mycology - April 24, 2024 Category: Biology Authors: Shi-Jie KangLing ZhaoHaiqiang WangJin ‑Ming GaoJianzhao Qia Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A & F University, Yangling, Chinab Department of Pharmacy, School of Medicine, Xi ’ Source Type: research
Prebiotic utilisation provides Lactiplantibacillus plantarum a competitive advantage in vitro, but is not reflected by an increased intestinal fitness
Volume 16, Issue 1, January-December 2024 . (Source: Gut Microbes)
Source: Gut Microbes - April 24, 2024 Category: Microbiology Authors: Jori FuhrenMarkus SchwalbeJos BoekhorstChristiane R öschHenk A. ScholsMichiel Kleerebezema Host Microbe Interactomics Group, Wageningen University & Research, Wageningen, The Netherlandsb Laboratory of Food Chemistry, Wageningen University & Research, Source Type: research
Rituximab in non-systemic vasculitic neuropathy: a single-center experience
DiscussionAnti-CD20 therapy might be an alternative in NSVN patients requiring further treatment escalation or treatment switch due to side effects of corticosteroids or cyclophosphamide. (Source: Journal of Neurology)
Source: Journal of Neurology - April 24, 2024 Category: Neurology Source Type: research
Effects of a dietary intervention on cardiometabolic risk and food consumption in a workplace
by Archana Shrestha, Dipesh Tamrakar, Bhawana Ghinanju, Deepa Shrestha, Parashar Khadka, Bikram Adhikari, Jayana Shrestha, Suruchi Waiwa, Prajjwal Pyakurel, Niroj Bhandari, Biraj Man Karmacharya, Akina Shrestha, Rajeev Shrestha, Rajendra Dev Bhatta, Vasanti Malik, Josiemer Mattei, Donna Spiegelman
BackgroundWorksite-based health programs have shown positive impacts on employee health and have led to significant improvements in cardiovascular risk factor profiles. We aimed to determine the effect of cafeteria intervention on cardio-metabolic risk factors diet in a worksite setting (Dhulikhel Hospital) in Nepal. MethodsIn th...
Source: PLoS One - April 24, 2024 Category: Biomedical Science Authors: Archana Shrestha Source Type: research
