An alginate-confined peroxygenase-CLEA for styrene epoxidation
Chem Commun (Camb). 2021 May 14. doi: 10.1039/d1cc01868j. Online ahead of print.ABSTRACTOxyfunctionalisation reactions in neat substrate still pose a challenge for biocatalysis. Here, we report an alginate-confined peroxygenase-CLEA to catalyse the enantioselective epoxidation of cis-β-methylstyrene in a solvent-free reaction system achieving turnover numbers of 96 000 for the biocatalyst and epoxide concentrations of 48 mM.PMID:33987632 | DOI:10.1039/d1cc01868j (Source: Chemical Communications)
Source: Chemical Communications - May 14, 2021 Category: Chemistry Authors: Friederike E H Nintzel Yinqi Wu Matteo Planchestainer Martin Held Miguel Alcalde Frank Hollmann Source Type: research

Photoluminescence enhancement by controllable aggregation and polymerization of octanuclear gold clusters
Chem Commun (Camb). 2021 May 14. doi: 10.1039/d1cc01162f. Online ahead of print.ABSTRACTAggregation-induced luminescence behaviors of polynuclear metal clusters are intriguing but still mysterious to date. Herein, we synthesize a series of Au8 clusters with different peripheral ligands to investigate their different supramolecular assembly and distinguishable aggregation-induced luminescent behaviors in solution upon the variation of concentration and solvent polarity. Complex 1a is surrounded by two tetraphenyl ethylene (TPE) moieties, whose dense stacking engenders strong aggregation in solution. Furthermore, the incorpo...
Source: Chemical Communications - May 14, 2021 Category: Chemistry Authors: Biao Yang Han Wu Liang Zhao Source Type: research

Development of temperature dependent oxygen releasable nanofilm by modulating oxidation state of myoglobin
Chem Commun (Camb). 2021 May 14. doi: 10.1039/d1cc01545a. Online ahead of print.ABSTRACTControlled release of oxygen from myoglobin was achieved by modulating autoxidation of oxymyoglobin using ascorbic acid as a reductant by temperature variation. Long-term storage, prompt release and re-storage of oxygen were also available with this system. Furthermore, 20 nm thick nanofilms composed of oxymyoglobin and type I collagen containing ascorbic acid could successfully show autoxidation of oxymyoglobin in response to environmental temperature. The ultrathin nanofilms will be useful as oxygen-controlled releasable scaffolds for...
Source: Chemical Communications - May 14, 2021 Category: Chemistry Authors: Daisuke Tomioka Hirotaka Nakatsuji Shigeru Miyagawa Yoshiki Sawa Michiya Matsusaki Source Type: research

Filamentous chaperone protein-based hydrogel stabilizes enzymes against thermal inactivation
We report a filamentous chaperone-based protein hydrogel capable of stabilizing enzymes against thermal inactivation. The hydrogel backbone consists of a thermostable chaperone protein, the gamma-prefoldin (γPFD) from Methanocaldococcus jannaschii, which self-assembles into a fibrous structure. Specific coiled-coil interactions engineered into the wildtype γPFD trigger the formation of a cross-linked network of protein filaments. The structure of the filamentous chaperone is preserved through the designed coiled-coil interactions. The resulting hydrogel enables entrapped enzymes to retain greater activity after...
Source: Chemical Communications - May 14, 2021 Category: Chemistry Authors: Dawei Xu Samuel Lim Yuhong Cao Abner Abad Aubrey Nayeon Kang Douglas S Clark Source Type: research

Titanocene pnictinidene complexes
Chem Commun (Camb). 2021 May 14. doi: 10.1039/d1cc01305j. Online ahead of print.ABSTRACTThe phospha-Wittig reagent MesTerPPMe3 (MesTer = 2,6-{2,4,6-Me3-C6H2}-C6H3) and arsa-Wittig reagent DipTerAsPMe3 (DipTer = 2,6-{2,6-iPr2-C6H3}-C6H3) have been employed to synthesize the titanocene complexes Cp2Ti(PMe3)PnAr (Pn = P, As) with terminal phosphinidene or arsinidene ligands, respectively. Ab initio studies show that the description as singlet biradicaloids in their ground state is warranted.PMID:33989372 | DOI:10.1039/d1cc01305j (Source: Chemical Communications)
Source: Chemical Communications - May 14, 2021 Category: Chemistry Authors: Malte Fischer Fabian Rei ß Christian Hering-Junghans Source Type: research

An alginate-confined peroxygenase-CLEA for styrene epoxidation
Chem Commun (Camb). 2021 May 14. doi: 10.1039/d1cc01868j. Online ahead of print.ABSTRACTOxyfunctionalisation reactions in neat substrate still pose a challenge for biocatalysis. Here, we report an alginate-confined peroxygenase-CLEA to catalyse the enantioselective epoxidation of cis-β-methylstyrene in a solvent-free reaction system achieving turnover numbers of 96 000 for the biocatalyst and epoxide concentrations of 48 mM.PMID:33987632 | DOI:10.1039/d1cc01868j (Source: Chemical Communications)
Source: Chemical Communications - May 14, 2021 Category: Chemistry Authors: Friederike E H Nintzel Yinqi Wu Matteo Planchestainer Martin Held Miguel Alcalde Frank Hollmann Source Type: research

Photoluminescence enhancement by controllable aggregation and polymerization of octanuclear gold clusters
Chem Commun (Camb). 2021 May 14. doi: 10.1039/d1cc01162f. Online ahead of print.ABSTRACTAggregation-induced luminescence behaviors of polynuclear metal clusters are intriguing but still mysterious to date. Herein, we synthesize a series of Au8 clusters with different peripheral ligands to investigate their different supramolecular assembly and distinguishable aggregation-induced luminescent behaviors in solution upon the variation of concentration and solvent polarity. Complex 1a is surrounded by two tetraphenyl ethylene (TPE) moieties, whose dense stacking engenders strong aggregation in solution. Furthermore, the incorpo...
Source: Chemical Communications - May 14, 2021 Category: Chemistry Authors: Biao Yang Han Wu Liang Zhao Source Type: research

Development of temperature dependent oxygen releasable nanofilm by modulating oxidation state of myoglobin
Chem Commun (Camb). 2021 May 14. doi: 10.1039/d1cc01545a. Online ahead of print.ABSTRACTControlled release of oxygen from myoglobin was achieved by modulating autoxidation of oxymyoglobin using ascorbic acid as a reductant by temperature variation. Long-term storage, prompt release and re-storage of oxygen were also available with this system. Furthermore, 20 nm thick nanofilms composed of oxymyoglobin and type I collagen containing ascorbic acid could successfully show autoxidation of oxymyoglobin in response to environmental temperature. The ultrathin nanofilms will be useful as oxygen-controlled releasable scaffolds for...
Source: Chemical Communications - May 14, 2021 Category: Chemistry Authors: Daisuke Tomioka Hirotaka Nakatsuji Shigeru Miyagawa Yoshiki Sawa Michiya Matsusaki Source Type: research

Filamentous chaperone protein-based hydrogel stabilizes enzymes against thermal inactivation
We report a filamentous chaperone-based protein hydrogel capable of stabilizing enzymes against thermal inactivation. The hydrogel backbone consists of a thermostable chaperone protein, the gamma-prefoldin (γPFD) from Methanocaldococcus jannaschii, which self-assembles into a fibrous structure. Specific coiled-coil interactions engineered into the wildtype γPFD trigger the formation of a cross-linked network of protein filaments. The structure of the filamentous chaperone is preserved through the designed coiled-coil interactions. The resulting hydrogel enables entrapped enzymes to retain greater activity after...
Source: Chemical Communications - May 14, 2021 Category: Chemistry Authors: Dawei Xu Samuel Lim Yuhong Cao Abner Abad Aubrey Nayeon Kang Douglas S Clark Source Type: research

Titanocene pnictinidene complexes
Chem Commun (Camb). 2021 May 14. doi: 10.1039/d1cc01305j. Online ahead of print.ABSTRACTThe phospha-Wittig reagent MesTerPPMe3 (MesTer = 2,6-{2,4,6-Me3-C6H2}-C6H3) and arsa-Wittig reagent DipTerAsPMe3 (DipTer = 2,6-{2,6-iPr2-C6H3}-C6H3) have been employed to synthesize the titanocene complexes Cp2Ti(PMe3)PnAr (Pn = P, As) with terminal phosphinidene or arsinidene ligands, respectively. Ab initio studies show that the description as singlet biradicaloids in their ground state is warranted.PMID:33989372 | DOI:10.1039/d1cc01305j (Source: Chemical Communications)
Source: Chemical Communications - May 14, 2021 Category: Chemistry Authors: Malte Fischer Fabian Rei ß Christian Hering-Junghans Source Type: research

Highly enantioselective tandem cycloisomerization/Diels-Alder reaction of 2-(1-alkynyl)-2-alken-1-ones and enals: dual catalysis with platinum and amines
Chem Commun (Camb). 2021 May 13. doi: 10.1039/d1cc02080c. Online ahead of print.ABSTRACTHerein, we disclosed a highly efficient strategy of enantioselective synthesis of 2,3-furan-fused carbocycles bearing three-contiguous stereocenters. This transformation is catalyzed by dual catalysis of PtCl4/chiral amines via tandem dehydrogenative annulation/Diels-Alder reaction of 2-(1-alkynyl)-2-alken-1-ones and enals. The in situ generation of the furan-based ortho-quinodimethane intermediates and the iminium activation of enals are crucial to this transformation.PMID:33982035 | DOI:10.1039/d1cc02080c (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Liejin Zhou Lu Liu Source Type: research

A new mode of cyclobutenedione ring opening for the synthesis of 2-oxobut-3-enamides and tetrasubstituted furans
Chem Commun (Camb). 2021 May 13. doi: 10.1039/d1cc02097h. Online ahead of print.ABSTRACTA dichotomy between the additions of organolithiums and lithium amides to cyclobutenediones is described wherein the former give carbonyl addition products while the latter induce ring opening by enone cleavage via O- to C-lithium transfer. This distinct mode of ring scission gives access to 2-oxobut-3-enamides and tetrasubstituted furans.PMID:33982046 | DOI:10.1039/d1cc02097h (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Ryan M Bennett Wei Sun Dharyl C Wilson Mark E Light David C Harrowven Source Type: research

In vivo monitoring of volatile metabolic trajectories enables rapid diagnosis of influenza A infection
We report that influenza A virus infection induces changes in odor traits that could be captured by real-time high-resolution mass spectrometry in a living mouse model. The most striking changes in the volatile metabolites may be associated mostly to glyoxylate/dicarboxylate metabolism.PMID:33982681 | DOI:10.1039/d1cc01061a (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Zhihong Yin Wenbo Huang Kapil Dev Singh Zhaoming Chen Xing Chen Zhen Zhou Zifeng Yang Pablo Sinues Xue Li Source Type: research

Sulfuroxygen interaction-controlled ( < em > Z < /em > )-selective < em > anti < /em > -Markovnikov vinyl sulfides
Chem Commun (Camb). 2021 May 13. doi: 10.1039/d1cc01257f. Online ahead of print.ABSTRACTThe sulfur oxygen (SO) interaction was used herein to obtain (Z)-selective anti-Markovnikov vinyl sulfides from the addition of thiyl radicals to terminal alkynes. DFT calculations predicted that SO interaction originated from the delocalization of the lone-pair of the carbonyl oxygen to the adjacent σ* orbital of the S atom of C-S.PMID:33982682 | DOI:10.1039/d1cc01257f (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Milan Pramanik Ashis Mathuri Prasenjit Mal Source Type: research

A near-infrared fluorescent probe for accurately diagnosing cancer by sequential detection of cysteine and H < sup > < /sup >
Chem Commun (Camb). 2021 May 14;57(39):4811-4814. doi: 10.1039/d1cc01228b. Epub 2021 Apr 16.ABSTRACTA near-infrared fluorescent probe, CyAc, is synthesized for accurately diagnosing cancer in vivo by sequential detection of Cys and H+. CyAc can not only achieve a good distinction between normal cells and cancer cells, but also distinguish normal mice from tumor mice.PMID:33982685 | DOI:10.1039/d1cc01228b (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Zun-Pan She Wen-Xin Wang Guo-Jiang Mao Wen-Li Jiang Zhi-Qing Wang Yongfei Li Chun-Yan Li Source Type: research

Nanodisc reconstitution of flavin mononucleotide binding domain of cytochrome-P450-reductase enables high-resolution NMR probing
Chem Commun (Camb). 2021 May 14;57(39):4819-4822. doi: 10.1039/d1cc01018b. Epub 2021 Apr 16.ABSTRACTCytochrome-P450-reductase transfers electrons to cytochrome-P450 through its flavin mononucleotide binding domain (FBD). Despite the importance of membrane-anchoring for FBD function, studies have focused on its soluble domain lacking the transmembrane-domain. Here we demonstrate that the reconstitution of FBD in nanodiscs enables high-resolution NMR measurements and renders a stable conformation.PMID:33982687 | DOI:10.1039/d1cc01018b (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Bankala Krishnarjuna Toshio Yamazaki G M Anantharamaiah Ayyalusamy Ramamoorthy Source Type: research

Construction of an optically controllable CRISPR-Cas9 system using a DNA origami nanostructure
Chem Commun (Camb). 2021 May 13. doi: 10.1039/d1cc00876e. Online ahead of print.ABSTRACTWe demonstrated the photo-controlled sequence-selective dsDNA cleavage using a DNA origami structure with Cas9 nuclease. The activity of Cas9 incorporated inside the ring-shaped DNA origami was completely suppressed. After photoirradiation, Cas9 was released, and its activity for selective dsDNA cleavage was restored.PMID:33982688 | DOI:10.1039/d1cc00876e (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Katsuhiko Abe Hiroshi Sugiyama Masayuki Endo Source Type: research

All-carbon phosphoranes < em > via < /em > difluorocarbene trapping
Chem Commun (Camb). 2021 May 13;57(39):4823-4826. doi: 10.1039/d1cc01075a.ABSTRACTA reaction of intramolecularly disposed phosphonium and phenoxide (or thiophenoxide) fragments with difluorocarbene affording all-carbon λ5-phosphoranes is described. The presence of electron-withdrawing CHF2-groups at the phosphonium center is important for the phosphorane formation. In a phosphorane, both phenyl groups located in the equatorial positions undergo 1,2-P,C migration under thermal conditions.PMID:33982701 | DOI:10.1039/d1cc01075a (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Vladimir O Smirnov Alexander D Volodin Alexander A Korlyukov Alexander D Dilman Source Type: research

An expedient synthesis of highly functionalized 1,3-dienes by employing cyclopropenes as < em > C < /em > < sub > 4 < /sub > units
Chem Commun (Camb). 2021 May 13. doi: 10.1039/d1cc01254a. Online ahead of print.ABSTRACTAn efficient method has been described to synthesize dicarbonyl functionalized 1,3-dienes by cleaving the C[double bond, length as m-dash]C bond of enaminones with cyclopropenes in the presence of a rhodium catalyst. The acetate-substituted cyclopropenes are judiciously chosen as standard C4 units of 1,3-diene precursors. The reactions are believed to undergo a unique cutting and insertion process, involving a C[double bond, length as m-dash]C bond cleavage of the enaminone and insertion of a new C(sp2) source with the formation of two ...
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Chengzhou Jiang Jiamin Wu Jiabin Han Kai Chen Yang Qian Zhengyu Zhang Yaojia Jiang Source Type: research

Synthesis of 2-isoxazolyl-2,3-dihydrobenzofurans < em > via < /em > palladium-catalyzed cascade cyclization of alkenyl ethers
Chem Commun (Camb). 2021 May 13;57(39):4799-4802. doi: 10.1039/d1cc00709b.ABSTRACTA novel palladium-catalyzed cascade cyclization reaction of alkenyl ethers with alkynyl oxime ethers for the construction of poly-heterocyclic scaffolds has been developed, in which the electron-rich alkene moiety functions as a three-atom unit, simultaneously dealing well with the coordination and regioselectivity of electron-rich olefins under metal catalysis. The strategy features excellent regio- and chemoselectivities as well as good functional group tolerance. Moreover, the newly formed 2-isoxazolyl-2,3-dihydrobenzofuran products can be...
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Fei Zhou Can Li Meng Li Yangbin Jin Huanfeng Jiang Yingjun Zhang Wanqing Wu Source Type: research

Confronting molecular rotors and self-quenched dimers as fluorogenic BODIPY systems to probe biotin receptors in cancer cells
Chem Commun (Camb). 2021 May 13;57(39):4807-4810. doi: 10.1039/d1cc00108f.ABSTRACTProbing receptors at the cell surface to monitor their expression level can be performed with fluorogenic dyes. Biotin receptors (BRs) are particularly interesting as they are overexpressed in cancer cells. Herein, to image BRs, we adapted and systematically compared two fluorogenic systems based on BODIPYs: a molecular rotor and a self-quenched dimer that light up in response to high viscosity and low polarity of the membrane, respectively. The fluorogenic dimer proved to be more efficient than the rotor and allowed BRs to be imaged in cance...
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Kyong T Fam Lazare Saladin Andrey S Klymchenko Mayeul Collot Source Type: research

Co-self-assembly of multiple DNA origami nanostructures in a single pot
Chem Commun (Camb). 2021 May 13;57(39):4795-4798. doi: 10.1039/d1cc00049g.ABSTRACTSimultaneous self-assembly of two distinct DNA origami nanostructures folded with the same scaffold strand was achieved in a single pot. Relative yields were tuned by adjusting concentrations of the competing strands, correlating well with folding kinetics of individual structures. These results can faciliate efficient fabrication of multi-structure systems and materials.PMID:33982710 | DOI:10.1039/d1cc00049g (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Joshua A Johnson Vasiliki Kolliopoulos Carlos E Castro Source Type: research

Interrogating biomineralization one amino acid at a time: amplification of mutational effects in protein-aided titania morphogenesis through reaction-diffusion control
Chem Commun (Camb). 2021 May 13;57(39):4803-4806. doi: 10.1039/d1cc01521d.ABSTRACTTo emulate the control that biomineralizing organisms exert over reactant transport, we construct a countercurrent reaction-diffusion chamber in which an agarose hydrogel regulates the fluxes of inorganic precursor and precipitating solid-binding protein. We show that the morphology of the bioprecipitated titania can be changed from monolithic to interconnected particle networks and dispersed nanoparticles either by decreasing reaction time or by increasing agarose weight percentage at constant precursor and protein concentrations. More strik...
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Karthik Pushpavanam Brittney Hellner Fran çois Baneyx Source Type: research

Vanadium dioxide nanostructures with remarkable surface-enhanced Raman scattering activity
Chem Commun (Camb). 2021 May 13;57(39):4815-4818. doi: 10.1039/d0cc08105a.ABSTRACTStructure and size control are always considered to be effective routes to enhance the sensitivity of materials. Herein, rough VO2 (D) nanostars and nanospheres with highly dense and rough surfaces were synthesized. Accompanied by the properties inherited from the rough VO2 nanospheres, i.e., high adsorption and strong plasma resonance, these VO2 (D) nanospheres exhibit highly sensitive activity as a surface enhanced Raman spectrum substrate. The detection limit of Rhodamine 6G on this semiconductor SERS substrate is as low as 10-9 M.PMID:339...
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Haomin Guan Zheng Tian Qinghong Kong Guangcheng Xi Source Type: research

Palladium catalyzed divergent cycloadditions of vinylidenecyclopropane-diesters with methyleneindolinones enabled by zwitterionic π-propargyl palladium species
Chem Commun (Camb). 2021 May 13;57(39):4783-4786. doi: 10.1039/d1cc01453f.ABSTRACTA palladium-catalyzed divergent synthesis of spirooxindoles fused with a five- or a six-membered ring by a cycloaddition reaction of vinylidenecyclopropane-diesters with methyleneindolinones was disclosed. This protocol features an in situ generated unprecedented zwitterionic π-propargyl palladium species in cycloaddition reactions and a switchable process between (3+2) and (4+2) cycloadditions by changing the phosphine ligand.PMID:33982717 | DOI:10.1039/d1cc01453f (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Ben Niu Yin Wei Min Shi Source Type: research

A layer-by-layer assembled D/L-arginine-calix[4]arene-Si-surface for macroscopic enantio-selective discrimination of ( < em > R < /em > )/( < em > S < /em > )-ibuprofen
Chem Commun (Camb). 2021 May 13. doi: 10.1039/d1cc01307f. Online ahead of print.ABSTRACTChiral arginine was introduced by layer-by-layer assembly onto a calix[4]arene-diacid modified silica surface to control the adsorption of different kinds of ibuprofen droplets. The droplet of (S)-ibuprofen slid off rapidly, whereas the droplet of (R)-ibuprofen absorbed on the modified surface.PMID:33982718 | DOI:10.1039/d1cc01307f (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Xiong Li Yingying Yang Jiaxin Quan Jin Zhang Ming Cheng Hewei Yan Siyun Zhang Lei Yang Zhiyan Lu Haibing Li Source Type: research

Sensitive, general and portable detection of RNAs combining duplex-specific nuclease transduction with an off-shelf signalling platform
We report a novel RNA sensing platform by combining the RNA:DNA hybridization, duplex-specific nuclease (DSN) amplification, and personal glucose meter (PGM) readout. The so-called DSN-PGM sensing platform is sensitive, specific and general to both microRNA and long virus RNA. The detection procedure is simple and instrument-free, thus holding particular potential in the development of portable and point-of-care measurements.PMID:33982719 | DOI:10.1039/d1cc01715b (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Lulu Guo Huan Li Rujian Zhao Yidan Tang Bingling Li Source Type: research

Visible-light-induced ligand to metal charge transfer excitation enabled phosphorylation of aryl halides
Chem Commun (Camb). 2021 May 13. doi: 10.1039/d1cc01858b. Online ahead of print.ABSTRACTWe herein described a visible light induced nickel(II)-catalyzed cross-coupling of secondary phosphine oxides with aryl halides. The Ni(I) species and chlorine atom radical Cl˙ were generated via the ligand to metal charge transfer (LMCT) process of the NiCl2(PPh3)2, which allows nickel(IV)-phosphorus species in situ formation, giving various tertiary phosphine oxides under photocatalyst-free conditions.PMID:33982720 | DOI:10.1039/d1cc01858b (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Hong Hou Bing Zhou Jiawei Wang Duhao Sun Huaguang Yu Xiaoyun Chen Ying Han Yaocheng Shi Chaoguo Yan Shaoqun Zhu Source Type: research

Direct functionalization of cyclic ethers with maleimide iodides < em > via < /em > free radial-mediated sp < sup > 3 < /sup > C-H activation
Chem Commun (Camb). 2021 May 13;57(39):4787-4790. doi: 10.1039/d1cc01484f.ABSTRACTCyclic ethers are important scaffolds employed in the synthesis of various natural products and pharmaceutical ingredients. A novel free radical-initiated reaction between cyclic ethers and maleimide iodides through C-H activation is developed, avoiding the use of transition metallic catalysts. This method provides a simple approach to derive cyclic ethers, which were further applied in various cross coupling reactions.PMID:33982730 | DOI:10.1039/d1cc01484f (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Xiaoyu Cheng Baojun Li Mengsi Zhang Haotian Lu Wenbo Wang Yun Ding Aiguo Hu Source Type: research

Late-stage ligand functionalization < em > via < /em > the Staudinger reaction using phosphine-appended 2,2'-bipyridine
Chem Commun (Camb). 2021 May 13. doi: 10.1039/d1cc01407b. Online ahead of print.ABSTRACTThe ability of a phosphine-appended-2,2'-bipyridine ligand ((Ph2P)2bpy) to serve as a platform for late-stage ligand modifications was evaluated using tetrahedral (Ph2P)2bpyFeCl2. We employed a post-metalation Staudinger reaction to install a series of functionalized arenes, including those containing Brønsted and Lewis acidic groups. This reaction sequence represents a versatile strategy to both tune the ligand donor properties as well as directly incorporate appended functionality.PMID:33982731 | DOI:10.1039/d1cc01407b (Source:...
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Deeb Taher Jessica R Wilson Grayson Ritch Matthias Zeller Nathaniel K Szymczak Source Type: research

Highly enantioselective tandem cycloisomerization/Diels-Alder reaction of 2-(1-alkynyl)-2-alken-1-ones and enals: dual catalysis with platinum and amines
Chem Commun (Camb). 2021 May 13. doi: 10.1039/d1cc02080c. Online ahead of print.ABSTRACTHerein, we disclosed a highly efficient strategy of enantioselective synthesis of 2,3-furan-fused carbocycles bearing three-contiguous stereocenters. This transformation is catalyzed by dual catalysis of PtCl4/chiral amines via tandem dehydrogenative annulation/Diels-Alder reaction of 2-(1-alkynyl)-2-alken-1-ones and enals. The in situ generation of the furan-based ortho-quinodimethane intermediates and the iminium activation of enals are crucial to this transformation.PMID:33982035 | DOI:10.1039/d1cc02080c (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Liejin Zhou Lu Liu Source Type: research

A new mode of cyclobutenedione ring opening for the synthesis of 2-oxobut-3-enamides and tetrasubstituted furans
Chem Commun (Camb). 2021 May 13. doi: 10.1039/d1cc02097h. Online ahead of print.ABSTRACTA dichotomy between the additions of organolithiums and lithium amides to cyclobutenediones is described wherein the former give carbonyl addition products while the latter induce ring opening by enone cleavage via O- to C-lithium transfer. This distinct mode of ring scission gives access to 2-oxobut-3-enamides and tetrasubstituted furans.PMID:33982046 | DOI:10.1039/d1cc02097h (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Ryan M Bennett Wei Sun Dharyl C Wilson Mark E Light David C Harrowven Source Type: research

In vivo monitoring of volatile metabolic trajectories enables rapid diagnosis of influenza A infection
We report that influenza A virus infection induces changes in odor traits that could be captured by real-time high-resolution mass spectrometry in a living mouse model. The most striking changes in the volatile metabolites may be associated mostly to glyoxylate/dicarboxylate metabolism.PMID:33982681 | DOI:10.1039/d1cc01061a (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Zhihong Yin Wenbo Huang Kapil Dev Singh Zhaoming Chen Xing Chen Zhen Zhou Zifeng Yang Pablo Sinues Xue Li Source Type: research

Sulfuroxygen interaction-controlled ( < em > Z < /em > )-selective < em > anti < /em > -Markovnikov vinyl sulfides
Chem Commun (Camb). 2021 May 13. doi: 10.1039/d1cc01257f. Online ahead of print.ABSTRACTThe sulfur oxygen (SO) interaction was used herein to obtain (Z)-selective anti-Markovnikov vinyl sulfides from the addition of thiyl radicals to terminal alkynes. DFT calculations predicted that SO interaction originated from the delocalization of the lone-pair of the carbonyl oxygen to the adjacent σ* orbital of the S atom of C-S.PMID:33982682 | DOI:10.1039/d1cc01257f (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Milan Pramanik Ashis Mathuri Prasenjit Mal Source Type: research

A near-infrared fluorescent probe for accurately diagnosing cancer by sequential detection of cysteine and H < sup > < /sup >
Chem Commun (Camb). 2021 May 14;57(39):4811-4814. doi: 10.1039/d1cc01228b. Epub 2021 Apr 16.ABSTRACTA near-infrared fluorescent probe, CyAc, is synthesized for accurately diagnosing cancer in vivo by sequential detection of Cys and H+. CyAc can not only achieve a good distinction between normal cells and cancer cells, but also distinguish normal mice from tumor mice.PMID:33982685 | DOI:10.1039/d1cc01228b (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Zun-Pan She Wen-Xin Wang Guo-Jiang Mao Wen-Li Jiang Zhi-Qing Wang Yongfei Li Chun-Yan Li Source Type: research

Nanodisc reconstitution of flavin mononucleotide binding domain of cytochrome-P450-reductase enables high-resolution NMR probing
Chem Commun (Camb). 2021 May 14;57(39):4819-4822. doi: 10.1039/d1cc01018b. Epub 2021 Apr 16.ABSTRACTCytochrome-P450-reductase transfers electrons to cytochrome-P450 through its flavin mononucleotide binding domain (FBD). Despite the importance of membrane-anchoring for FBD function, studies have focused on its soluble domain lacking the transmembrane-domain. Here we demonstrate that the reconstitution of FBD in nanodiscs enables high-resolution NMR measurements and renders a stable conformation.PMID:33982687 | DOI:10.1039/d1cc01018b (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Bankala Krishnarjuna Toshio Yamazaki G M Anantharamaiah Ayyalusamy Ramamoorthy Source Type: research

Construction of an optically controllable CRISPR-Cas9 system using a DNA origami nanostructure
Chem Commun (Camb). 2021 May 13. doi: 10.1039/d1cc00876e. Online ahead of print.ABSTRACTWe demonstrated the photo-controlled sequence-selective dsDNA cleavage using a DNA origami structure with Cas9 nuclease. The activity of Cas9 incorporated inside the ring-shaped DNA origami was completely suppressed. After photoirradiation, Cas9 was released, and its activity for selective dsDNA cleavage was restored.PMID:33982688 | DOI:10.1039/d1cc00876e (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Katsuhiko Abe Hiroshi Sugiyama Masayuki Endo Source Type: research

Front cover
Chem Commun (Camb). 2021 May 14;57(39):4741. doi: 10.1039/D1CC90171K. Epub 2021 May 13.NO ABSTRACTPMID:33982691 | DOI:10.1039/D1CC90171K (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Source Type: research

Inside front cover
Chem Commun (Camb). 2021 May 14;57(39):4742. doi: 10.1039/D1CC90172A. Epub 2021 May 13.NO ABSTRACTPMID:33982692 | DOI:10.1039/D1CC90172A (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Source Type: research

Contents list
Chem Commun (Camb). 2021 May 14;57(39):4743-4750. doi: 10.1039/D1CC90173G. Epub 2021 May 13.NO ABSTRACTPMID:33982693 | DOI:10.1039/D1CC90173G (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Source Type: research

Inside back cover
Chem Commun (Camb). 2021 May 14;57(39):4863. doi: 10.1039/D1CC90174E. Epub 2021 May 13.NO ABSTRACTPMID:33982694 | DOI:10.1039/D1CC90174E (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Source Type: research

Back cover
Chem Commun (Camb). 2021 May 14;57(39):4864. doi: 10.1039/D1CC90175C. Epub 2021 May 13.NO ABSTRACTPMID:33982695 | DOI:10.1039/D1CC90175C (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Source Type: research

All-carbon phosphoranes < em > via < /em > difluorocarbene trapping
Chem Commun (Camb). 2021 May 13;57(39):4823-4826. doi: 10.1039/d1cc01075a.ABSTRACTA reaction of intramolecularly disposed phosphonium and phenoxide (or thiophenoxide) fragments with difluorocarbene affording all-carbon λ5-phosphoranes is described. The presence of electron-withdrawing CHF2-groups at the phosphonium center is important for the phosphorane formation. In a phosphorane, both phenyl groups located in the equatorial positions undergo 1,2-P,C migration under thermal conditions.PMID:33982701 | DOI:10.1039/d1cc01075a (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Vladimir O Smirnov Alexander D Volodin Alexander A Korlyukov Alexander D Dilman Source Type: research

An expedient synthesis of highly functionalized 1,3-dienes by employing cyclopropenes as < em > C < /em > < sub > 4 < /sub > units
Chem Commun (Camb). 2021 May 13. doi: 10.1039/d1cc01254a. Online ahead of print.ABSTRACTAn efficient method has been described to synthesize dicarbonyl functionalized 1,3-dienes by cleaving the C[double bond, length as m-dash]C bond of enaminones with cyclopropenes in the presence of a rhodium catalyst. The acetate-substituted cyclopropenes are judiciously chosen as standard C4 units of 1,3-diene precursors. The reactions are believed to undergo a unique cutting and insertion process, involving a C[double bond, length as m-dash]C bond cleavage of the enaminone and insertion of a new C(sp2) source with the formation of two ...
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Chengzhou Jiang Jiamin Wu Jiabin Han Kai Chen Yang Qian Zhengyu Zhang Yaojia Jiang Source Type: research

Front cover
Chem Commun (Camb). 2021 May 13;57(39):4741. doi: 10.1039/d1cc90171k.NO ABSTRACTPMID:33982706 | DOI:10.1039/d1cc90171k (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Source Type: research

Synthesis of 2-isoxazolyl-2,3-dihydrobenzofurans < em > via < /em > palladium-catalyzed cascade cyclization of alkenyl ethers
Chem Commun (Camb). 2021 May 13;57(39):4799-4802. doi: 10.1039/d1cc00709b.ABSTRACTA novel palladium-catalyzed cascade cyclization reaction of alkenyl ethers with alkynyl oxime ethers for the construction of poly-heterocyclic scaffolds has been developed, in which the electron-rich alkene moiety functions as a three-atom unit, simultaneously dealing well with the coordination and regioselectivity of electron-rich olefins under metal catalysis. The strategy features excellent regio- and chemoselectivities as well as good functional group tolerance. Moreover, the newly formed 2-isoxazolyl-2,3-dihydrobenzofuran products can be...
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Fei Zhou Can Li Meng Li Yangbin Jin Huanfeng Jiang Yingjun Zhang Wanqing Wu Source Type: research

Confronting molecular rotors and self-quenched dimers as fluorogenic BODIPY systems to probe biotin receptors in cancer cells
Chem Commun (Camb). 2021 May 13;57(39):4807-4810. doi: 10.1039/d1cc00108f.ABSTRACTProbing receptors at the cell surface to monitor their expression level can be performed with fluorogenic dyes. Biotin receptors (BRs) are particularly interesting as they are overexpressed in cancer cells. Herein, to image BRs, we adapted and systematically compared two fluorogenic systems based on BODIPYs: a molecular rotor and a self-quenched dimer that light up in response to high viscosity and low polarity of the membrane, respectively. The fluorogenic dimer proved to be more efficient than the rotor and allowed BRs to be imaged in cance...
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Kyong T Fam Lazare Saladin Andrey S Klymchenko Mayeul Collot Source Type: research

Co-self-assembly of multiple DNA origami nanostructures in a single pot
Chem Commun (Camb). 2021 May 13;57(39):4795-4798. doi: 10.1039/d1cc00049g.ABSTRACTSimultaneous self-assembly of two distinct DNA origami nanostructures folded with the same scaffold strand was achieved in a single pot. Relative yields were tuned by adjusting concentrations of the competing strands, correlating well with folding kinetics of individual structures. These results can faciliate efficient fabrication of multi-structure systems and materials.PMID:33982710 | DOI:10.1039/d1cc00049g (Source: Chemical Communications)
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Joshua A Johnson Vasiliki Kolliopoulos Carlos E Castro Source Type: research

Interrogating biomineralization one amino acid at a time: amplification of mutational effects in protein-aided titania morphogenesis through reaction-diffusion control
Chem Commun (Camb). 2021 May 13;57(39):4803-4806. doi: 10.1039/d1cc01521d.ABSTRACTTo emulate the control that biomineralizing organisms exert over reactant transport, we construct a countercurrent reaction-diffusion chamber in which an agarose hydrogel regulates the fluxes of inorganic precursor and precipitating solid-binding protein. We show that the morphology of the bioprecipitated titania can be changed from monolithic to interconnected particle networks and dispersed nanoparticles either by decreasing reaction time or by increasing agarose weight percentage at constant precursor and protein concentrations. More strik...
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Karthik Pushpavanam Brittney Hellner Fran çois Baneyx Source Type: research

Vanadium dioxide nanostructures with remarkable surface-enhanced Raman scattering activity
Chem Commun (Camb). 2021 May 13;57(39):4815-4818. doi: 10.1039/d0cc08105a.ABSTRACTStructure and size control are always considered to be effective routes to enhance the sensitivity of materials. Herein, rough VO2 (D) nanostars and nanospheres with highly dense and rough surfaces were synthesized. Accompanied by the properties inherited from the rough VO2 nanospheres, i.e., high adsorption and strong plasma resonance, these VO2 (D) nanospheres exhibit highly sensitive activity as a surface enhanced Raman spectrum substrate. The detection limit of Rhodamine 6G on this semiconductor SERS substrate is as low as 10-9 M.PMID:339...
Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Haomin Guan Zheng Tian Qinghong Kong Guangcheng Xi Source Type: research