Assembly of branched ubiquitin oligomers by click chemistry.
Abstract Ubiquitin monomers functionalized with an azide or multiple alkynes were utilized for the assembly of branched ubiquitin oligomers (K6/K11, K11/K48, K11/K63, K6/K11/K48) by click chemistry. The oligomers resist deubiquitylase-catalysed hydrolysis and exhibit stability in eukaryotic cell lysates. PMID: 31612161 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 15, 2019 Category: Chemistry Authors: Zhao X, Scheffner M, Marx A Tags: Chem Commun (Camb) Source Type: research

Selective and sensitive fluorescence "turn-on" detection of 4-thiouridine in nucleic acids via oxidative amination.
Selective and sensitive fluorescence "turn-on" detection of 4-thiouridine in nucleic acids via oxidative amination. Chem Commun (Camb). 2019 Oct 15;: Authors: Wang J, Shang J, Qin Z, Tong A, Xiang Y Abstract A fluorescence "turn-on" method for digestion-free analysis of 4-thiouridine (s4U) in nucleic acids was developed in this work based on the oxidative amination of s4U by fluoresceinamine (FAM-NH2) and periodate (IO4-). It was 125-fold more sensitive for s4U detection than the traditional UV330 absorption method, and showed excellent selectivity to s4U over 2-thiouridine (s2U) a...
Source: Chemical Communications - October 15, 2019 Category: Chemistry Authors: Wang J, Shang J, Qin Z, Tong A, Xiang Y Tags: Chem Commun (Camb) Source Type: research

Polymyxin derivatives as broad-spectrum antibiotic agents.
Abstract We designed a few polymyxin derivatives which exhibit broad-spectrum antimicrobial activity. Lead compound P1 could disrupt bacterial membranes rapidly without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in an MRSA-infected thigh burden mouse model. PMID: 31612170 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 15, 2019 Category: Chemistry Authors: Su M, Wang M, Hong Y, Nimmagadda A, Shen N, Shi Y, Gao R, Zhang E, Cao C, Cai J Tags: Chem Commun (Camb) Source Type: research

Ultramacrocyclization via selective catenation in water.
Abstract A set of two cyclic [2]catenane dimers were self-assembled in aqueous media via selective hydrazone condensation, by means of either one-pot or post-functionalization procedures. Considering that each catenane is composed of two thirty-six member rings, each of these two cyclic [2]catenane dimers can be considered as a ultra-large macrocycle that contains more than fifty atoms in the ring framework. This cyclization methodology relying on catenation thus represents a novel approach for accomplishing ultramacrocyclization in pure water. PMID: 31612173 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 15, 2019 Category: Chemistry Authors: Chen Q, Chen L, Wang CY, Jiao T, Pan Y, Li H Tags: Chem Commun (Camb) Source Type: research

Organo metal halide perovskites effectively photosensitize the production of singlet oxygen (1 Δg).
Organo metal halide perovskites effectively photosensitize the production of singlet oxygen (1Δg). Chem Commun (Camb). 2019 Oct 15;: Authors: Zhang XF, Xu B Abstract Using the steady state and time resolved NIR emission and specific chemical trapping techniques, we show for the first time that metal halide perovskite quantum dots can effectively generate singlet oxygen with a quantum yield of up to 0.34, the highest among nano semiconductor/nano metal singlet oxygen photosensitizers. The mechanism is concluded to be due to energy transfer from triplet excitons to molecular oxygen. PMID: 316...
Source: Chemical Communications - October 15, 2019 Category: Chemistry Authors: Zhang XF, Xu B Tags: Chem Commun (Camb) Source Type: research

Four consecutive reactions in one pot: cascade formation of an unprecedented triphosphatricyclo[3.2.1.02,7]oct-3-ene.
, Müller C Abstract A hitherto unknown triphosphatricyclo[3.2.1.02,7]oct-3-ene was obtained in high yield by a total of four consecutive pericyclic reactions from di-2-pyrone and excess TMS-C[triple bond, length as m-dash]P. DFT calculations gave insight into the reaction mechanism. The chiral phosphorus cage readily forms coordination compounds with Au(i) and Cu(i). PMID: 31612181 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 15, 2019 Category: Chemistry Authors: Giese S, Buzsáki D, Nyulászi L, Müller C Tags: Chem Commun (Camb) Source Type: research

Retraction: Differential detection and quantification of cyclic AMP and other adenosine phosphates in live cells.
Abstract Retraction of 'Differential detection and quantification of cyclic AMP and other adenosine phosphates in live cells' by Sujoy Das et al., Chem. Commun., 2017, 53, 7600-7603. PMID: 31612871 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 15, 2019 Category: Chemistry Authors: Das S, Sarkar HS, Uddin MR, Rissanen K, Mandal S, Sahoo P Tags: Chem Commun (Camb) Source Type: research

Correction: Unravelling a general mechanism of converting ionic B/N complexes into neutral B/N analogues of alkanes: H δ+Hδ- dihydrogen bonding assisted dehydrogenation.
Correction: Unravelling a general mechanism of converting ionic B/N complexes into neutral B/N analogues of alkanes: Hδ+Hδ- dihydrogen bonding assisted dehydrogenation. Chem Commun (Camb). 2019 Oct 15;: Authors: Chen XM, Liu SC, Xu CQ, Jing Y, Wei D, Li J, Chen X Abstract Correction for 'Unravelling a general mechanism of converting ionic B/N complexes into neutral B/N analogues of alkanes: Hδ+Hδ- dihydrogen bonding assisted dehydrogenation' by Xi-Meng Chen et al., Chem. Commun., 2019, 55, 12239-12242. PMID: 31612873 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 15, 2019 Category: Chemistry Authors: Chen XM, Liu SC, Xu CQ, Jing Y, Wei D, Li J, Chen X Tags: Chem Commun (Camb) Source Type: research

Combining sol-gel and microfluidics processes for the synthesis of protein-containing hybrid microgels.
oisselle JM Abstract Biocompatible chemical cross-linked hybrid polyethylene glycol-based hydrogels were obtained from a sol-gel process using bis-silylated molecular precursors in biocompatible conditions. This soft procedure (pH = 7.4, at 25 °C), allows the production of microgels by microfluidics and easy encapsulation of a model protein (Bovin Serum Albumine, BSA). PMID: 31612874 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 15, 2019 Category: Chemistry Authors: Tourné-Péteilh C, Robin B, Lions M, Martinez J, Mehdi A, Subra G, Devoisselle JM Tags: Chem Commun (Camb) Source Type: research

"Off-on" switching of intracellular singlet oxygen release under biocompatible conditions.
"Off-on" switching of intracellular singlet oxygen release under biocompatible conditions. Chem Commun (Camb). 2019 Oct 15;: Authors: Ucar E, Xi D, Seven O, Kaya C, Peng X, Sun W, Akkaya EU Abstract Precise spatiotemporal control of singlet oxygen generation is of immense importance considering its involvement in photodynamic therapy. In this work, we present a rational design for an endoperoxide which is highly stable at ambient temperatures yet, can rapidly be converted into a highly labile endoperoxide, thus releasing the "stored" singlet oxygen on demand. The "off-on"...
Source: Chemical Communications - October 15, 2019 Category: Chemistry Authors: Ucar E, Xi D, Seven O, Kaya C, Peng X, Sun W, Akkaya EU Tags: Chem Commun (Camb) Source Type: research

Etchable SERS nanosensor for accurate pH and hydrogen peroxide sensing in living cells.
Abstract No methodology has been built to distinguish intracellular SERS nanosensors from cell outer membrane bound-ones. Here we propose a "turning off" strategy by combining etchable SERS nanosensors with a non-permeable etchant. The SERS signals outside the living cells can be rapidly removed, leaving only the internalized nanosensors for imaging and thereby allowing accurate intracellular pH and H2O2 sensing. PMID: 31608348 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 14, 2019 Category: Chemistry Authors: Bai L, Wang X, Zhang K, Tan X, Zhang Y, Xie W Tags: Chem Commun (Camb) Source Type: research

Correction: Fluorescence of a chiral pentaphene derivative derived from the hexabenzocoronene Motif.
r S Abstract Correction for 'Fluorescence of a chiral pentaphene derivative derived from the hexabenzocoronene Motif' by Philipp Rietsch et al., Chem. Commun., 2019, 55, 10515-10518. PMID: 31608351 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 14, 2019 Category: Chemistry Authors: Rietsch P, Soyka J, Brülls S, Er J, Hoffmann K, Beerhues J, Sarkar B, Resch-Genger U, Eigler S Tags: Chem Commun (Camb) Source Type: research

[Au7Ag9(dppf)3(CF3CO2)7BF4]n: a linear nanocluster polymer from molecular Au7Ag8 clusters covalently linked by silver atoms.
We report the total structure determination of a covalently bonded nanocluster polymer [Au7Ag9(dppf)3(CF3CO2)7BF4]n (1). This features a one-dimensional linear chain, consisting of unique molecular building blocks, Au7Ag8(dppf)3(CF3CO2)7 clusters, which are linked together by Ag-O bonds rather than Au-Au interactions or bidentate organic bridges as previously reported. PMID: 31608354 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 14, 2019 Category: Chemistry Authors: Wen ZR, Guan ZJ, Zhang Y, Lin YM, Wang QM Tags: Chem Commun (Camb) Source Type: research

Ultrasensitive photoelectrochemical microRNA biosensor based on doxorubicin sensitized graphitic carbon nitride assisted by a target-activated enzyme-free DNA walker.
Abstract Herein, a photoelectrochemical biosensor was successfully constructed on the basis of a sensitization strategy of doxorubicin sensitized graphitic carbon nitride for the ultrasensitive detection of microRNA-141 with the assistance of a target-activated enzyme-free DNA walker. PMID: 31608901 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 14, 2019 Category: Chemistry Authors: Wang Y, Xia L, Wei C, Wang H, Wang H, Yuan R, Wei S Tags: Chem Commun (Camb) Source Type: research

A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy.
Abstract A distyryl boron dipyrromethene based photosensitiser substituted with 1,2,4,5-tetrazine and alkyne moieties was prepared. Through site-specific bioorthogonal reactions with the complementary functional tags anchored on the membrane of A431 human epidermoid carcinoma cells, this versatile photosensitiser exhibited enhanced cellular uptake and photocytotoxicity. The bioorthogonal ligation was also demonstrated in tumour-bearing nude mice. PMID: 31608902 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 14, 2019 Category: Chemistry Authors: Guo X, Wong RCH, Zhou Y, Ng DKP, Lo PC Tags: Chem Commun (Camb) Source Type: research

Molecular spinning top: visualizing the dynamics of M3N@C80 with variable temperature single crystal X-ray diffraction.
Abstract Variable temperature X-ray diffraction studies on two single crystals containing M3N@C80, i.e., Ho2LuN@C80·NiOEP·2(C6H6) and Lu3N@C80·NiOEP·2(C6H6), (NiOEP = Nickel octaethylporphyrin) unravelled the temperature dependent rotation of the M3N cluster and C80 cage on the static NiOEP molecule. PMID: 31608903 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 14, 2019 Category: Chemistry Authors: Liu F, Spree L Tags: Chem Commun (Camb) Source Type: research

Direct monitoring of equilibrium protein folding-unfolding by atomic force microscopy: pushing the limit.
We report the direct observation of equilibrium folding-unfolding dynamics of a mechanically labile, three helix bundle protein GA using a commercial atomic force microscope (AFM). Our study extends the capability of commercial AFMs towards studying protein unfolding/refolding at equilibrium as well as increasingly complex biomolecular systems in the context of biological function. PMID: 31608905 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 14, 2019 Category: Chemistry Authors: Xiao A, Li H Tags: Chem Commun (Camb) Source Type: research

Visible light-mediated selective α-functionalization of 1,3-dicarbonyl compounds via disulfide induced aerobic oxidation.
Visible light-mediated selective α-functionalization of 1,3-dicarbonyl compounds via disulfide induced aerobic oxidation. Chem Commun (Camb). 2019 Oct 14;: Authors: Zhao J, Yang F, Yu Z, Tang X, Wu Y, Ma C, Meng Q Abstract A visible light-mediated α-functionalization of 1,3-dicarbonyl compounds with switchable selectivity induced by disulfide is disclosed. Upon irradiation with visible light, the metal- and base-free α-hydroxylation or α-hydroxymethylation reaction proceeded smoothly through a disulfide-catalyzed oxidation under mild conditions. The combination of a continuous-...
Source: Chemical Communications - October 14, 2019 Category: Chemistry Authors: Zhao J, Yang F, Yu Z, Tang X, Wu Y, Ma C, Meng Q Tags: Chem Commun (Camb) Source Type: research

Ultrasonication-promoted synthesis of luminescent sulfur nano-dots for cellular imaging applications.
Abstract An ultrasonication-promoted strategy was proposed to synthesize luminescent S-dots, which reduced the synthesis time from the commonly used 5 days to several hours. The as-synthesized S-dots show a high photostability and low cytotoxicity, and are then successfully applied for cellular imaging. PMID: 31608907 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 14, 2019 Category: Chemistry Authors: Zhang C, Zhang P, Ji X, Wang H, Kuang H, Cao W, Pan M, Shi YE, Wang Z Tags: Chem Commun (Camb) Source Type: research

The dilemma between acid and base catalysis in the synthesis of benzimidazole from o-phenylenediamine and carbon dioxide.
Abstract The tandem synthesis of benzimidazole and other azoles can be achived by the N-formylation of ortho-substituted anilines followed by a cyclization reaction. However, CO2-based N-formylations with hydrosilane reducing agents are base catalyzed whereas the cyclization reaction is acid catalyzed. The mismatch in catalytic conditions means that only one of the steps can be catalyzed in a single pot reaction. While the N-formylation reaction is frequently the target of catalyst development, the cyclization reaction requires comparably much harsher reaction conditions. Identification of these difficulties lead ...
Source: Chemical Communications - October 14, 2019 Category: Chemistry Authors: Hulla M, Nussbaum S, Bonnin AR, Dyson PJ Tags: Chem Commun (Camb) Source Type: research

Strong circularly polarized luminescence of an octahedral chromium(iii) complex.
Abstract The chiral spin-flip luminophore [Cr(ddpd)2]3+ can be resolved into enantiopure material by chiral HPLC. The corresponding enantiomers show very high luminescence dissymmetry factors of up to ∣glum ∣≈ 0.093 in circularly polarized luminescence (CPL) measurements for the "ruby-like" phosphorescence transition 2E/2T1 → 4A2 in the near-IR region around λ ≈ 775 nm. PMID: 31608909 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 14, 2019 Category: Chemistry Authors: Dee C, Zinna F, Kitzmann WR, Pescitelli G, Heinze K, Di Bari L, Seitz M Tags: Chem Commun (Camb) Source Type: research

Small molecule activation by multimetallic uranium complexes supported by siloxide ligands.
Abstract The synthesis and reactivity of uranium compounds supported by the tris-tert-butoxysiloxide ligand is surveyed. The multiple binding modes of the tert-butoxysiloxide ligand have proven very well suited to stabilize highly reactive homo- and heteropolymetallic complexes of uranium that have shown an unusual high reactivity towards small molecules such as CO2, CS2, chalcogens and azides. Moreover, these ligands have allowed the isolation of dinuclear nitride and oxide bridged complexes of uranium in various oxidation states. The ability of the tris-tert-butoxysiloxide ligands to trap alkali ions in these ni...
Source: Chemical Communications - October 14, 2019 Category: Chemistry Authors: Barluzzi L, Falcone M, Mazzanti M Tags: Chem Commun (Camb) Source Type: research

UV-cured gel polymer electrolytes with improved stability for advanced aqueous Li-ion batteries.
We report the development of a new class of "water-in-salt" electrolytes based on UV photopolymerized acrylic polymers. Incorporation of "water-in-bisalt" in a polymer matrix reduces water activity, expands the electrochemical stability window to 4.1 V, and dramatically improves cycle life in full cells with lithium titanate anodes compared to liquid water-based electrolytes. PMID: 31608913 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 14, 2019 Category: Chemistry Authors: Langevin SA, Tan B, Freeman AW, Gagnon JC, Hoffman CM, Logan MW, Maranchi JP, Gerasopoulos K Tags: Chem Commun (Camb) Source Type: research

Highly chemoselective difluoromethylative homologation of iso(thio)cyanates: expeditious access to unprecedented α,α-difluoro(thio)amides.
Highly chemoselective difluoromethylative homologation of iso(thio)cyanates: expeditious access to unprecedented α,α-difluoro(thio)amides. Chem Commun (Camb). 2019 Oct 11;: Authors: Miele M, D'Orsi R, Sridharan V, Holzer W, Pace V Abstract The new motif - α,α-difluoromethyl thioamide - has been assembled starting from isothiocyanate (as thioamide precursor) and a formal difluoromethyl-carbanion generated from commercially available TMSCHF2. Upon proper activation of this reagent with potassium tert-amylate, the high-yielding transfer of the difluorinated nucleophile takes place...
Source: Chemical Communications - October 11, 2019 Category: Chemistry Authors: Miele M, D'Orsi R, Sridharan V, Holzer W, Pace V Tags: Chem Commun (Camb) Source Type: research

Chromenopyrazole-based bipolar host materials for solution-processable thermally activated delayed fluorescence OLEDs exhibiting high efficiency and low roll-off.
This study reports the design, synthesis, and characterization of two new bipolar host materials, DCzCP and TCzCP. Both materials were implemented as hosts by doping a known green thermally activated delayed fluorescent (TADF) emitter (t4CzIPN) in solution-processable OLEDs. DCzCP-based devices afford the best performance with the maximum external quantum efficiency (EQE) of 21.2%. Notably, the EQE was maintained at 20.7% and 19.7% at a practical luminance of 500 cd m-2 and 1000 cd m-2, respectively, demonstrating very small roll-off. PMID: 31602441 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 11, 2019 Category: Chemistry Authors: Godumala M, Yoon J, Lee C, Jeong JE, Park S, Woo HY, Cho MJ, Choi DH Tags: Chem Commun (Camb) Source Type: research

A novel Mn-Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion.
Abstract A bimetallic complex, containing Mn(ii) and Cu(ii) moieties, was synthesized for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a hydroxyl radical (˙OH) via a Fenton-like reaction involving a Mn complex, and simultaneously depleting glutathione via a Cu complex induced oxidative reaction, thereby enhancing the efficiency of CDT. PMID: 31602444 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 11, 2019 Category: Chemistry Authors: Cao S, Fan J, Sun W, Li F, Li K, Tai X, Peng X Tags: Chem Commun (Camb) Source Type: research

Advances in helicene derivatives with circularly polarized luminescence.
Abstract Chiral materials have been widely present in people's lives, and their in-depth application research is underway. Generally, the circularly polarized light obtained from nonpolarized light through filters would result in brightness loss. Scientists have found that chirality can be introduced into organic compounds to obtain circularly polarized luminescence (CPL). Chiral compounds with CPL properties have attracted great attention and interest in recent years for their wide potential applications in 3D information displays, quantum communication, spintronics information storage, CPL lasers, nonlinear opti...
Source: Chemical Communications - October 11, 2019 Category: Chemistry Authors: Zhao WL, Li M, Lu HY, Chen CF Tags: Chem Commun (Camb) Source Type: research

A robust MOF-based trap with high-density active alkyl thiol for the super-efficient capture of mercury.
Abstract The first Zr-based metal-organic frameworks (MOFs) with high-density active alkyl thiol were successfully constructed in an aqueous phase. Thanks to the strong affinity between alkyl thiol and Hg2+ ions, the robust MOFs feature high adsorption capacity (734 mg g-1), ultra-fast kinetics (removing 99.99% Hg2+ in 5 min), super-high capture efficiency (dropping Hg2+ concentration from 10 000 ppb to 0.11 ppb), wide working range of pH, high selectivity and good reusability. PMID: 31603149 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 11, 2019 Category: Chemistry Authors: Yang P, Shu Y, Zhuang Q, Li Y, Gu J Tags: Chem Commun (Camb) Source Type: research

Bicyclic (amino)(borata)carbene derived from diazadiborinine and isonitrile.
Abstract The reaction of 1,4,2,5-diazadiborinine (1) with two equivalents of an aryl isonitrile afforded a bicyclic product containing an indole unit (2) or ketenimine moiety (3), suggesting the generation of a B,N-carbene intermediate formed via a [4+2] cycloaddition reaction in the initial step. The employment of the tolyl(phenyl isonitrile)gold complex (PhNCAuTol) as the substrate allowed the bicyclic (amino)(borata)carbene gold complexes (4, 5) to be accessed. PMID: 31603151 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 11, 2019 Category: Chemistry Authors: Wang B, Koshino K, Kinjo R Tags: Chem Commun (Camb) Source Type: research

Calcium stannyl formation by organostannane dehydrogenation.
Abstract Reaction of the dimeric calcium hydride, [(BDI)CaH]2 (1), with Ph3SnH ensues with elimination of H2 to provide [(BDI)Ca-μ2-H-(SnPh3)Ca(BDI)] (3) and [(BDI)Ca(SnPh3)]2 (4) alongside dismutation to Ph4Sn, H2 and Sn(0). DFT analysis indicates that stannyl anion formation occurs through deprotonation of Ph3SnH and with retention of dinuclear species throughout the reactions. PMID: 31603152 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 11, 2019 Category: Chemistry Authors: Morris LJ, Hill MS, Manners I, McMullin CL, Mahon MF, Rajabi NA Tags: Chem Commun (Camb) Source Type: research

Super electron donor-mediated reductive desulfurization reactions.
Abstract The desulfurization of thioacetals and thioethers by a pyridine-derived electron donor is described. This methodology provides efficient access to the reduced products in high yields and does not require the use of transition-metals, elemental alkali-metals, or hydrogen atom donors. PMID: 31603153 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 11, 2019 Category: Chemistry Authors: Nozawa-Kumada K, Ito S, Noguchi K, Shigeno M, Kondo Y Tags: Chem Commun (Camb) Source Type: research

Self-assembly of aliphatic dipeptides coupled with porphyrin and BODIPY chromophores.
Abstract In this work, the self assembly ability of chromophores covalently linked to aliphatic dipeptides is described. Altering various parameters such as the protecting group, the solvent mixture, the dipeptide and the chromophore resulted in different nanostructures. Interestingly, a peptide-porphyrin hybrid is capable of forming a hydrogel in HFIP-water solvent mixture. PMID: 31603154 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 11, 2019 Category: Chemistry Authors: Nikoloudakis E, Mitropoulou K, Landrou G, Charalambidis G, Nikolaou V, Mitraki A, Coutsolelos AG Tags: Chem Commun (Camb) Source Type: research

A robust photocatalyst of Au25@ZIF-8@TiO2-ReP with dual photoreductive sites to promote photoelectron utilization in H2O splitting to H2 and CO2 reduction to CO.
We report a remarkable improvement of the activity and stability of a Au25@ZIF-8@TiO2-ReP catalyst via composition engineering with double redox active sites of Au25 NCs and a Re(i) complex for H2 and CO evolution to promote electron utilization. PMID: 31603164 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 11, 2019 Category: Chemistry Authors: Tian L, Luo Y, Chu K, Wu D, Shi J, Liang Z Tags: Chem Commun (Camb) Source Type: research

Enantioselective aryl-aryl coupling facilitated by chiral binuclear gold complexes.
Abstract Herein, we report stoichiometric investigations embodying the first highly enantioselective aryl-aryl coupling facilitated by a gold complex. With up to 91% ee, this is the first demonstration of a transmetalation and C(sp2)-C(sp2) reductive elimination sequence with high enantioselectivity using a gold complex. The results offer a basis for development of enantioselective gold-catalyzed aryl-aryl coupling reactions. PMID: 31603439 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 11, 2019 Category: Chemistry Authors: Himmelstrup J, Buendia MB, Sun XW, Kramer S Tags: Chem Commun (Camb) Source Type: research

An ultrasensitive electrochemiluminescence biosensor for nuclear factor kappa B p50 based on the proximity hybridization-induced hybridization chain reaction.
In this study, a highly selective and sensitive electrochemiluminescence (ECL) biosensor for the detection of NF-κB p50 has been developed, which combines the high selectivity of the proximity hybridization assay (PHA) with the high efficiency of the hybridization chain reaction (HCR). PMID: 31603440 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 11, 2019 Category: Chemistry Authors: Huang X, Zhang Y, Xu W, Xu W, Guo L, Qiu B, Lin Z Tags: Chem Commun (Camb) Source Type: research

Double metal cyanides as heterogeneous Lewis acid catalysts for nitrile synthesis via acid-nitrile exchange reactions.
Abstract A series of transition metal-based double metal cyanides (DMCs) were studied as catalysts for the synthesis of nitriles via acid-nitrile exchange reaction. The best nitrile yields were obtained with Co3[Co(CN6)]2 DMC, which proved to be a versatile, stable, reusable and highly active catalyst, exhibiting an activity comparable to that of homogeneous Lewis acid catalysts. PMID: 31603443 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 11, 2019 Category: Chemistry Authors: Marquez C, Corbet M, Smolders S, Marion P, De Vos D Tags: Chem Commun (Camb) Source Type: research

Asymmetric aerobic decarboxylative Povarov reactions of N-aryl α-amino acids with methylenephthalimidines via cooperative photoredox and chiral Brønsted acid catalysis.
Asymmetric aerobic decarboxylative Povarov reactions of N-aryl α-amino acids with methylenephthalimidines via cooperative photoredox and chiral Brønsted acid catalysis. Chem Commun (Camb). 2019 Oct 11;: Authors: Li J, Gu Z, Zhao X, Qiao B, Jiang Z Abstract An enantioselective aerobic decarboxylative Povarov reaction of N-aryl α-amino acids with methylenephthalimidines through cooperative photoredox and chiral Brønsted acid catalysis is reported. With a transition metal-free dual catalytic system including a chiral phosphoric acid and DPZ as a photosensitizer mediated by visib...
Source: Chemical Communications - October 11, 2019 Category: Chemistry Authors: Li J, Gu Z, Zhao X, Qiao B, Jiang Z Tags: Chem Commun (Camb) Source Type: research

Handy fluorescent paper device based on a curcumin derivative for ultrafast detection of peroxide-based explosives.
We report a handy, simple and inexpensive paper device for extremely sensitive detection of peroxide-based explosives. The sensing device fabricated using a curcumin derivative was capable of ultrafast sensing of triacetone triperoxide. The detection time was below 5 s. Moreover, the sensor retained full function under storage at ambient temperature for at least 120 days. PMID: 31603447 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 11, 2019 Category: Chemistry Authors: Zhu QH, Zhang GH, Yuan WL, Wang SL, He L, Yong F, Tao GH Tags: Chem Commun (Camb) Source Type: research

A chromenone analog as an ATP-competitive, DNA non-intercalative topoisomerase II catalytic inhibitor with preferences toward the alpha isoform.
Abstract 5-Hydroxy-2-phenyl-7-(thiiran-2-ylmethoxy)-4H-chromen-4-one (compound 52) was found as a DNA non-intercalative topo II specific catalytic inhibitor by targeting its ATP-binding domain. Showing changes in interaction with Mg2+, it exhibited highly selective properties against the α-isoform with less toxicity, unlike other topo II poisons, such as etoposide. PMID: 31598611 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 10, 2019 Category: Chemistry Authors: Park S, Hwang SY, Shin J, Jo H, Na Y, Kwon Y Tags: Chem Commun (Camb) Source Type: research

Defective glycerolatocobalt(ii) for enhancing the oxygen evolution reaction.
This study expanded the family of metal-organic complexes for electrocatalysis and proved the critical role of CUMs in the OER directly. PMID: 31598613 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 10, 2019 Category: Chemistry Authors: He J, Zou Y, Wang S Tags: Chem Commun (Camb) Source Type: research

Site-selective modification of tryptophan and protein tryptophan residues through PdNP bionanohybrid-catalysed C-H activation in aqueous media.
Abstract Herein we report for the first time the site-selective C-H bond arylation of tryptophan and tryptophan residues in proteins in aqueous media at room temperature by using a PdNP bionanohybrid as a heterogeneous catalyst. The reaction proceeds using a stable aryldiazonium salt without a base. PMID: 31599273 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 10, 2019 Category: Chemistry Authors: Perez-Rizquez C, Abian O, Palomo JM Tags: Chem Commun (Camb) Source Type: research

Surfactant-templated zeolites for the production of active pharmaceutical intermediates.
acute;nez J Abstract A hierarchical USY zeolite has been produced using the surfactant-templating method and used as a catalyst for the production of two important active pharmaceutical ingredients. The presence of intracrystalline mesoporosity in the zeolite results in a significant increase in both the activity (up to 30 fold increase in TOF) and reusability for Friedel-Crafts alkylation and aldol condensation steps. PMID: 31599274 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 10, 2019 Category: Chemistry Authors: Linares N, Cirujano FG, De Vos DE, García-Martínez J Tags: Chem Commun (Camb) Source Type: research

Facile synthesis of sub-10 nm-sized bright red-emitting upconversion nanophosphors via tetrahedral YOF:Yb,Er seed-mediated growth.
Abstract Ultrasmall and uniform tetrahedral-shaped YOF:Yb,Er upconversion nanophosphors (UCNs) are synthesized and sub-10 nm YOF:Yb,Er/YOF core/shell UCNs are formed via YOF:Yb,Er seed-mediated synthesis. The ultrasmall YOF:Yb,Er/YOF core/shell UCNs realize intense red emission under near infrared light (λex = 980 nm). PMID: 31599275 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 10, 2019 Category: Chemistry Authors: Kang M, Kang HB, Park S, Jang HS Tags: Chem Commun (Camb) Source Type: research

Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging.
Abstract Here, we report the development of novel PET radiotracer ([11C]CW22) of BET proteins. In vivo imaging results in rodents and nonhuman primates (NHP) demonstrate that [11C]CW22 has excellent brain uptake, good specificity, good selectivity, suitable metabolism, appropriate kinetics and distribution in the brain. Our studies demonstrated that [11C]CW22 exhibits ideal properties as a PET imaging probe of BET proteins for further validation. PMID: 31599282 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 10, 2019 Category: Chemistry Authors: Bai P, Wey HY, Patnaik D, Lu X, Lan Y, Rokka J, Stephanie F, Haggarty SJ, Wang C Tags: Chem Commun (Camb) Source Type: research

Development of 4-oxime-1,8-naphthalimide as a bioorthogonal turn-on probe for fluorogenic protein labeling.
Abstract 4-Oxime-1,8-naphthalimide was reported as a novel bioorthogonal turn-on probe based on 1,3-dipolar cycloaddition reactions between in situ generated nitrile oxide and alkenes/alkynes. The resulting isoxazole products displayed dramatically strong fluorescence enhancement upon photoirradiation through isoxazole-oxazole photoisomerization. This new methodology was successfully applied for in situ fluorogenic protein labeling. PMID: 31599283 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 10, 2019 Category: Chemistry Authors: Tian Y, Li X, Yin D Tags: Chem Commun (Camb) Source Type: research

A silver-manganese dual co-catalyst for selective reduction of carbon dioxide into carbon monoxide over a potassium hexatitanate photocatalyst with water.
Abstract A Ag-Mn dual co-catalyst deposited on a K2Ti6O13 photocatalyst significantly enhances the photocatalytic CO2 reduction into CO with an extremely high selectivity of 98% by using H2O as an electron donor, owing to the properties of Ag and MnOx species for promoting CO and O2 formation, respectively. PMID: 31599285 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 10, 2019 Category: Chemistry Authors: Zhu X, Yamamoto A, Imai S, Tanaka A, Kominami H, Yoshida H Tags: Chem Commun (Camb) Source Type: research

Light-controlled efficient photoluminescence based on an europium β-diketonate complex with single-crystal-to-single-crystal [2+2] cycloaddition.
Light-controlled efficient photoluminescence based on an europium β-diketonate complex with single-crystal-to-single-crystal [2+2] cycloaddition. Chem Commun (Camb). 2019 Oct 10;: Authors: Zhang J, Li J, Feng X, Kong M, Hu ZB, Zheng YX, Song Y Abstract A brand new europium(iii) β-diketonate complex undergoes a single-crystal-to-single-crystal transformation via [2+2] cycloaddition after UV irradiation, triggering strong Eu(iii) red emission turn-on, which is highly photostable even after 50 hours of irradiation. A photo-patterning process is successfully conducted for security printing appli...
Source: Chemical Communications - October 10, 2019 Category: Chemistry Authors: Zhang J, Li J, Feng X, Kong M, Hu ZB, Zheng YX, Song Y Tags: Chem Commun (Camb) Source Type: research

SO2 conversion to sulfones: development and mechanistic insights of a sulfonylative Hiyama cross-coupling.
tat T Abstract A Pd-catalyzed Hiyama cross-coupling reaction using SO2 is described. The use of silicon-based nucleophiles leads to the formation of allyl sulfones under mild conditions with a broad functional group tolerance. Control experiments coupled with DFT calculations shed light on the key steps of the reaction mechanism, revealing the crucial role of a transient sulfinate anion. PMID: 31599297 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 10, 2019 Category: Chemistry Authors: Adenot A, Char J, von Wolff N, Lefèvre G, Anthore-Dalion L, Cantat T Tags: Chem Commun (Camb) Source Type: research

Highly isoselective ring-opening polymerization of rac-O-carboxyanhydrides using a zinc alkoxide initiator.
Abstract The stereoselective ring-opening polymerization (ROP) of O-carboxyanhydrides (OCAs) remains a major challenge due to the easy epimerization of monomers. In this work, using a zinc alkoxide initiator, highly efficient ROP of enantiopure 5-methyl-1,3-dioxolane-2,4-dione (LacOCA), 5-benzyl-1,3-dioxolane-2,4-dione (PheOCA), and 5-(4-(benzyloxy)benzyl)-1,3-dioxolane-2,4-dione (Try(Bn)OCA) was achieved without obvious epimerization. Moreover, highly isoselective ROP of rac-LacOCA, rac-PheOCA, and rac-Try(Bn)OCA was successful with the highest isoselectivity of Pm = 0.97 at -70 °C. PMID: 31599885 [PubMe...
Source: Chemical Communications - October 10, 2019 Category: Chemistry Authors: Cui Y, Jiang J, Pan X, Wu J Tags: Chem Commun (Camb) Source Type: research

Dye-sensitized LaFeO3 photocathode for solar-driven H2 generation.
Abstract Mesoporous LaFeO3 was used as a p-type visible-light-absorbing semiconductor (VLAS) substrate for light-driven H2 generation. The successful modification of LaFeO3 with a molecular dye (P1*) and a molecular hydrogen production catalyst (NiP) paved a novel way to construct DS-PEC photocathodes for solar-driven H2 generation by using VLASs. PMID: 31599888 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - October 10, 2019 Category: Chemistry Authors: Li F, Xu R, Nie C, Wu X, Zhang P, Duan L, Sun L Tags: Chem Commun (Camb) Source Type: research