Cyanation of glycine derivatives
We report a catalytic oxidative C-H cyanation of glycine derivatives using a simple copper(i) catalyst with NFSI as an oxidant via a radical process to furnish α-cyano glycine derivatives, which are useful intermediates for organic synthesis. CuCl acted as both a one-electron reductant and a transition-metal catalyst in this transformation. NFSI served as a one-electron oxidant and generated a N-centered radical as a H-abstractor. The reaction displayed broad substrate scope and mild reaction conditions.PMID:33623936 | DOI:10.1039/d0cc08126d (Source: Chemical Communications)
Source: Chemical Communications - February 24, 2021 Category: Chemistry Authors: Jia Liang Ying Fu Xiazhen Bao Lanlan Ou Tongzhi Sang Yong Yuan Congde Huo Source Type: research

Hybrid nanoreceptors for high sensitivity detection of small molecules by NMR chemosensing
Chem Commun (Camb). 2021 Feb 24. doi: 10.1039/d0cc07559k. Online ahead of print.ABSTRACT"Nanoparticle-assisted NMR chemosensing" combines magnetization transfer NMR techniques with the recognition abilities of gold nanoparticles (AuNPs) to isolate the NMR spectrum of relevant organic species in mixtures. The efficiency of the magnetization transfer is crucial to set the detection limit of the technique. To this aim, a second generation of nanoreceptors obtained by the self-organization of 2 nm AuNPs onto the surface of bigger silica nanoparticles shows better magnetization transfer performances, allowing the dete...
Source: Chemical Communications - February 24, 2021 Category: Chemistry Authors: Federico De Biasi Daniele Rosa-Gastaldo Fabrizio Mancin Federico Rastrelli Source Type: research

Oxidative cross-coupling processes inspired by the Chan-Lam reaction
Chem Commun (Camb). 2021 Feb 24. doi: 10.1039/d1cc00213a. Online ahead of print.ABSTRACTThe Cu-catalyzed oxidative cross-coupling of N- and O-nucleophiles with aryl boronic acids (the Chan-Lam reaction) remains among the most useful approaches to prepare aniline and phenol derivatives. The combination of high chemoselectivity, mild reaction conditions, and the ability to use simple Cu-salts as catalysts makes this process a valuable alternative to aromatic substitutions and Pd-catalyzed reactions of aryl electrophiles (Buchwald-Hartwig coupling). Despite the widespread use of Chan-Lam reactions in synthesis, the analogous ...
Source: Chemical Communications - February 24, 2021 Category: Chemistry Authors: Michael G J Doyle Rylan J Lundgren Source Type: research

The discovery of SKLB-0335 as a paralog-selective EZH2 covalent inhibitor
Chem Commun (Camb). 2021 Feb 24. doi: 10.1039/d0cc04670a. Online ahead of print.ABSTRACTBy targeting the unique Cys663 of EZH2, SKLB-0335 displays high paralog-selectivity on EZH2. Biochemical studies show that SKLB-0335 can covalently bind to EZH2 at its S-adenosylmethionine (SAM) pocket and inhibit H3K27Me3. SKLB-0335 could be an effective chemical probe with which to further investigate the specific biological functions of EZH2.PMID:33623946 | DOI:10.1039/d0cc04670a (Source: Chemical Communications)
Source: Chemical Communications - February 24, 2021 Category: Chemistry Authors: Qiangsheng Zhang Xi Hu Lu Li Lidan Zhang Guoquan Wan Qiang Feng Yongxia Zhu Ningyu Wang Zhihao Liu Luoting Yu Source Type: research

Self-assembly and guest-induced disassembly of triply interlocked [2]catenanes
Chem Commun (Camb). 2021 Feb 24. doi: 10.1039/d0cc08052g. Online ahead of print.ABSTRACTTwo fascinating triply interlocked [2]catenanes and one simple triangular prism metallacage were constructed by tuning the widths of the organometallic dinuclear building blocks. Notably, the interlocked architectures were disassembled in the presence of large aromatic molecules to form their corresponding monomeric host-guest complexes.PMID:33623947 | DOI:10.1039/d0cc08052g (Source: Chemical Communications)
Source: Chemical Communications - February 24, 2021 Category: Chemistry Authors: Ying-Ying Zhang Feng-Yi Qiu Hua-Tian Shi Weibin Yu Source Type: research

Interaction of cyclosporin A molecules with alkali and transition metal atoms on Cu(111)
Chem Commun (Camb). 2021 Feb 23. doi: 10.1039/d1cc00125f. Online ahead of print.ABSTRACTThe structure of a cyclic peptide with important biological functionalities, cyclosporin A (CsA), is investigated at the single molecule level. Its adsorption on Cu(111) under ultra-high vacuum is characterised with scanning tunnelling microscopy (STM) and density functional theory. With STM investigations, we demonstrate element specific on-surface coordination schemes of CsA with coadsorbed K, Co and Fe atoms. Thus, clear insights emerge in the behaviour of cyclic peptides at interfaces and their interactions with different metal atom...
Source: Chemical Communications - February 23, 2021 Category: Chemistry Authors: Yuanyuan Guo Li Jiang Ari Paavo Seitsonen Bodong Zhang Joachim Reichert Anthoula C Papageorgiou Johannes V Barth Source Type: research

Benzylidene succinimides as 3C synthons for the asymmetric tandem Mannich reaction/transamidation of cyclic trifluoromethyl ketimines to obtain F < sub > 3 < /sub > C-containing polycyclic dihydroquinazolinones
Chem Commun (Camb). 2021 Feb 23. doi: 10.1039/d0cc08131k. Online ahead of print.ABSTRACTBy taking advantage of benzylidene succinimides as a new class of 3C synthons, a highly diastereo- and enantioselective tandem Mannich reaction/transamidation has been established by reacting them with cyclic trifluoromethyl N-acyl ketimines. Using a Cinchona alkaloid-derived squaramide as the catalyst, the tandem reaction proceeded smoothly under mild conditions and afforded a range of F3C-containing chiral polycyclic dihydroquinazolinones with excellent results (up to 99% yield, all cases>20 : 1 dr, up to 99% ee).PMID:33620365 | DO...
Source: Chemical Communications - February 23, 2021 Category: Chemistry Authors: Xia-Yan Zhang Pei-Hao Dou Wen-Ya Lu Yong You Jian-Qiang Zhao Zhen-Hua Wang Wei-Cheng Yuan Source Type: research

Ultrasensitive visual detection of Hg < sup > 2+ < /sup > ions < em > via < /em > the Tyndall effect of gold nanoparticles
Chem Commun (Camb). 2021 Feb 23. doi: 10.1039/d0cc08003a. Online ahead of print.ABSTRACTThis work reports a new methodology for naked-eye nanosensing of Hg2+ where the Tyndall effect of gold nanoparticles (GNPs) acts as a light scattering signalling readout. Its utility is demonstrated with ultrasensitive detection of the target with a limit down to 0.13 nM (∼5461-fold sensitivity improvement over conventional GNP-based methods with surface plasmon resonance signalling).PMID:33621285 | DOI:10.1039/d0cc08003a (Source: Chemical Communications)
Source: Chemical Communications - February 23, 2021 Category: Chemistry Authors: Zihao Deng Wenying Jin Qiaobo Yin Jinkun Huang Ziheng Huang Haiyan Fu Yali Yuan Jianmei Zou Jinfang Nie Yun Zhang Source Type: research

The impact of the counterion in the performance of ionic hydrotropes
Chem Commun (Camb). 2021 Feb 23. doi: 10.1039/d0cc08092f. Online ahead of print.ABSTRACTThe efficiency of an ionic hydrotrope is shown to increase with the hydrophobicity of its counterion, challenging the common view that ionic hydrotropes should possess a small, densely charged counterion such as sodium or chloride.PMID:33621286 | DOI:10.1039/d0cc08092f (Source: Chemical Communications)
Source: Chemical Communications - February 23, 2021 Category: Chemistry Authors: Dinis O Abranches Jordana Benfica Bruna P Soares Ana M Ferreira T ânia E Sintra Seishi Shimizu Jo ão A P Coutinho Source Type: research

Understanding of TEMPO-electrocatalyzed acceptorless dehydrogenation of tetrahydroquinoline by < em > in situ < /em > extractive electrospray ionization mass spectrometry
Chem Commun (Camb). 2021 Feb 23. doi: 10.1039/d0cc08209k. Online ahead of print.ABSTRACTThe TEMPO-electrocatalyzed acceptorless dehydrogenation of tetrahydroquinoline, a transformation in green synthesis and hydrogen storage, has been investigated by coupling of an electrocatalytic system with in situ extraction electrospray ionization mass spectrometry. Dynamic changes in important species and intermediates were monitored, which evoked an updated AD understanding.PMID:33621287 | DOI:10.1039/d0cc08209k (Source: Chemical Communications)
Source: Chemical Communications - February 23, 2021 Category: Chemistry Authors: Weixiang Li Jianghui Sun Yan Wang Jinping Qiao Lixin He Jin Ouyang Na Na Source Type: research

The antibacterial activities of MoS < sub > 2 < /sub > nanosheets towards multi-drug resistant bacteria
Chem Commun (Camb). 2021 Feb 23. doi: 10.1039/d1cc00327e. Online ahead of print.ABSTRACTWe demonstrated that molybdenum disulfide (MoS2) nanosheets can be an excellent solar disinfection agent for multi-drug resistant (MDR) bacteria with disinfection efficiencies>99.9999% in only 30 min. Distinct from other reactive oxygen species (ROS)-dependent photocatalysts, both ROS generation and size decrease contributed to the high antibacterial efficiencies of MoS2.PMID:33621298 | DOI:10.1039/d1cc00327e (Source: Chemical Communications)
Source: Chemical Communications - February 23, 2021 Category: Chemistry Authors: Yingcan Zhao Yuexiao Jia Jiayi Xu Liang Han Feng He Xingyu Jiang Source Type: research

The < em > in situ < /em > formation of an electrolyte < em > via < /em > the lithiation of Mg(BH < sub > 4 < /sub > ) < sub > 2 < /sub > in an all-solid-state lithium battery
Chem Commun (Camb). 2021 Feb 23. doi: 10.1039/d0cc08366f. Online ahead of print.ABSTRACTThe present work proposes a new approach to increasing the capacity of all-solid-state batteries, based on the in situ formation of an electrolyte in a Mg(BH4)2 electrode. Charge/discharge assessments of the electrode composed of Mg(BH4)2 and acetylene black showed an initial reversible capacity of 563 mA h g-1-Mg(BH4)2.PMID:33621300 | DOI:10.1039/d0cc08366f (Source: Chemical Communications)
Source: Chemical Communications - February 23, 2021 Category: Chemistry Authors: Hiroki Sato Ryo Sakamoto Hironari Minami Hiroaki Izumi Keiko Ideta Atsushi Inoishi Shigeto Okada Source Type: research

Palladium-catalyzed diastereoselective cross-coupling of two aryl halides < em > via < /em > C-H activation: synthesis of chiral eight-membered nitrogen heterocycles
Chem Commun (Camb). 2021 Feb 23. doi: 10.1039/d1cc00398d. Online ahead of print.ABSTRACTA method for the synthesis of enantiopure eight-membered nitrogen heterocycles has been developed through diastereoselective cross-coupling of 2-iodobiphenyls with 2-bromobenzylamines. The products represent a novel type of chiral scaffold, which feature easy modification and high configurative stability and have the potential to be applied in asymmetric synthesis. Palladacycles that were formed via the C-H activation of 2-iodobiphenyls should act as the intermediates. The reaction provides a new strategy for the synthesis of medium-siz...
Source: Chemical Communications - February 23, 2021 Category: Chemistry Authors: Cang Cheng Xiang Zuo Dongdong Tu Bin Wan Yanghui Zhang Source Type: research

Fine-tuning of the optical output in a dual responsive catenane switch
Chem Commun (Camb). 2021 Feb 23. doi: 10.1039/d1cc00310k. Online ahead of print.ABSTRACTA [2]catenane switch where the intramolecular pyrene excimer emission can be controlled by orthogonal cation binding and solvent polarity change in various amplitudes and dynamic ranges is reported.PMID:33621303 | DOI:10.1039/d1cc00310k (Source: Chemical Communications)
Source: Chemical Communications - February 23, 2021 Category: Chemistry Authors: Yulin Deng Samuel Kin-Man Lai Linghui Kong Ho Yu Au-Yeung Source Type: research

Metal alkoxide-derived Co@NC/NCNS as a highly efficient bifunctional oxygen electrocatalyst
Chem Commun (Camb). 2021 Feb 23. doi: 10.1039/d1cc00431j. Online ahead of print.ABSTRACTA promising bifunctional catalyst integrating Co@NC units and porous structure carbon nanosheets (Co@NC/NCNS) is in situ prepared by the calcination and subsequent acid etching of a mixture containing metal alkoxide and melamine. Benefiting from the synergism among the active sites and porous structure, the optimal Co@NC/NCNS-800 exhibits superior activity for the ORR/OER.PMID:33621305 | DOI:10.1039/d1cc00431j (Source: Chemical Communications)
Source: Chemical Communications - February 23, 2021 Category: Chemistry Authors: Ying Wang Hongjie Yuan Fan Liu Tianjun Hu Source Type: research

A bioinspired oxoiron(IV) motif supported on a N < sub > 2 < /sub > S < sub > 2 < /sub > macrocyclic ligand
Chem Commun (Camb). 2021 Feb 23. doi: 10.1039/d1cc00250c. Online ahead of print.ABSTRACTA mononuclear oxoiron(iv) complex 1-trans bearing two equatorial sulfur ligations is synthesized and characterized as an active-site model of the elusive sulfur-ligated FeIV[double bond, length as m-dash]O intermediates in non-heme iron oxygenases. The introduction of sulfur ligands weakens the Fe[double bond, length as m-dash]O bond and enhances the oxidative reactivity of the FeIV[double bond, length as m-dash]O unit with a diminished deuterium kinetic isotope effect, thereby providing a compelling rationale for nature's use of the ci...
Source: Chemical Communications - February 23, 2021 Category: Chemistry Authors: Jennifer Deutscher Philipp Gerschel Katrin Warm Uwe Kuhlmann Stefan Mebs Michael Haumann Holger Dau Peter Hildebrandt Ulf-Peter Apfel Kallol Ray Source Type: research

Reversible polymorphic structural transition of crown-like nickel nanoclusters and its effect on conductivity
We report the reversible polymorphic phase transition of [Ni6(PET)12] (PET = phenylethanethiol) and its effect on the conductivity. This cluster's self-assembly leads to two polymorphic structures with distinct conductivity, caused by variation of the non-covalent SS interactions. These results enlighten the effect of non-covalent interactions on conductivity.PMID:33621307 | DOI:10.1039/d1cc00402f (Source: Chemical Communications)
Source: Chemical Communications - February 23, 2021 Category: Chemistry Authors: Manju P Maman Akashdeep Nath None Anjusree S Bikas C Das Sukhendu Mandal Source Type: research

Interfacial cationization to quicken redox-responsive drug release
Chem Commun (Camb). 2021 Feb 23. doi: 10.1039/d1cc00156f. Online ahead of print.ABSTRACTInterfacial cationization could greatly increase the redox-responsiveness of disulfide bond-linked lipid-drug nanoassemblies (NAs) due to the generation and concentration of ionized thiols at the alkalized NAs' cationic interface. This strategy could be used to prepare redox-ultrasensitive nanocarriers for efficient intracellular drug delivery.PMID:33621308 | DOI:10.1039/d1cc00156f (Source: Chemical Communications)
Source: Chemical Communications - February 23, 2021 Category: Chemistry Authors: Yaxin Zheng Jie Lei Qi Li Xuan Jin Qingyuan Li Yang Li Source Type: research

Redox switching of an artificial transmembrane signal transduction system
Chem Commun (Camb). 2021 Feb 22. doi: 10.1039/d0cc08322d. Online ahead of print.ABSTRACTTransmission of chemical signals across lipid bilayer membranes can be achieved using membrane-anchored molecules, where molecular motion across the bilayer is controlled by switching the polarity of two different head groups. An external redox signal delivered by ascorbic acid was used to trigger membrane translocation in a synthetic transduction system.PMID:33616133 | DOI:10.1039/d0cc08322d (Source: Chemical Communications)
Source: Chemical Communications - February 22, 2021 Category: Chemistry Authors: Lucia Trevisan Istvan Kocsis Christopher A Hunter Source Type: research

Non-symmetric mechanophores prepared from radical-type symmetric mechanophores: bespoke mechanofunctional polymers
Chem Commun (Camb). 2021 Feb 22. doi: 10.1039/d0cc08048a. Online ahead of print.ABSTRACTA non-symmetric radical-type mechanophore (CF/ABF) was synthesized by molecular crossing between two radical-type mechanophores. The thermal stability and mechanoresponsiveness of CF/ABF were found to be tunable by altering the properties of the parent RMs. The CF/ABF-centred polymers showed mixed mechanochromism derived from the simultaneous generation of two radical species.PMID:33616134 | DOI:10.1039/d0cc08048a (Source: Chemical Communications)
Source: Chemical Communications - February 22, 2021 Category: Chemistry Authors: Kosaku Yanada Sota Kato Daisuke Aoki Koichiro Mikami Hajime Sugita Hideyuki Otsuka Source Type: research

Gas sorption of nano-porous supramolecules formed by multi-hydrogen bonded coordination capsules
Chem Commun (Camb). 2021 Feb 22. doi: 10.1039/d0cc07869g. Online ahead of print.ABSTRACT[{ReI(CO)3(Hbim)}3(tpta)]2 (1, Hbim- = 2,2'-biimidazolate monoanion, tpta = 2,4,6-tripyridyl-1,3,5-triazine) was prepared as a nano-space supramolecule by using a new group of H-bonded coordination capsules. The hamburger bun-shaped half unit [{ReI(CO)3(Hbim)}3(tpta)] contains six intermolecular H-bonds of Hbim- ligands with complementary dual NHN types, and three [ReI(CO)3(Hbim)] are coordinated by bridging tridentate tpta. Interestingly, mechanical grinding easily would convert single crystals of 1 to an amorphous state with minor cry...
Source: Chemical Communications - February 22, 2021 Category: Chemistry Authors: Makoto Tadokoro Hironobu Machida Ryuji Toyofuku Megumi Murakami Hajime Kamebuchi Kyosuke Isoda Fumiya Kobayashi Kiyonori Takahashi Shin'ichiro Noro Takayoshi Nakamura Source Type: research

A continuous flow synthesis of [1.1.1]propellane and bicyclo[1.1.1]pentane derivatives
Chem Commun (Camb). 2021 Feb 22. doi: 10.1039/d0cc08124h. Online ahead of print.ABSTRACTA continuous flow process to generate [1.1.1]propellane on demand is presented rendering solutions of [1.1.1]propellane that can directly be derivatised into various bicyclo[1.1.1]pentane (BCP) species. This was realised in throughputs up to 8.5 mmol h-1 providing an attractive and straightforward access to gram quantities of selected BCP building blocks. Lastly, a continuous photochemical transformation of [1.1.1]propellane into valuable BCPs bearing mixed ester/acyl chloride moieties was developed.PMID:33616143 | DOI:10.1039/d0cc08124...
Source: Chemical Communications - February 22, 2021 Category: Chemistry Authors: Kian Donnelly Marcus Baumann Source Type: research

Accelerating the oxygen evolution reaction kinetics of Co < sub > 3 < /sub > O < sub > 4 < /sub > in neutral electrolyte by decorating RuO < sub > 2 < /sub >
Chem Commun (Camb). 2021 Feb 22. doi: 10.1039/d1cc00309g. Online ahead of print.ABSTRACTDeveloping efficient electrocatalysts for the neutral oxygen evolution reaction (OER) is important but still challenging. Herein, by combining density functional theory calculations and experiments, we have demonstrated that the decoration of RuO2 can effectively accelerate the OER kinetics of Co3O4 in neutral electrolyte. High activity (365 mV at 10 mA cm-2) and decent stability (up to 100 h) are achieved by RuO2-decorated Co3O4 in 1 M PBS electrolyte.PMID:33616145 | DOI:10.1039/d1cc00309g (Source: Chemical Communications)
Source: Chemical Communications - February 22, 2021 Category: Chemistry Authors: Kaifa Lu Guanru Chang Hui Zhang Xin-Yao Yu Source Type: research

Elimination of macrophage-entrapped antibiotic-resistant bacteria by a targeted metal-organic framework-based nanoplatform
Chem Commun (Camb). 2021 Feb 22. doi: 10.1039/d0cc08340b. Online ahead of print.ABSTRACTA novel metal-organic framework-based platform was designed and constructed for photosensitizer delivery for the elimination of intracellular antibiotic-resistant bacteria. With the merit of targeting and internalizing ability, the system could kill the stealthy bacteria efficiently under light irradiation.PMID:33616152 | DOI:10.1039/d0cc08340b (Source: Chemical Communications)
Source: Chemical Communications - February 22, 2021 Category: Chemistry Authors: Xuemeng Liu Qingqing Deng Lu Zhang Yanjuan Sang Kai Dong Jinsong Ren Xiaogang Qu Source Type: research

Size-selective synthesis of platinum nanoparticles on transition-metal dichalcogenides for the hydrogen evolution reaction
We report a micellar system to prepare Pt-TMDs composites with tunable Pt nanoparticles (NPs, 2-6 nm in size) on single-layer TMDs (MoS2, TiS2, TaS2) nanosheets. The Pt-MoS2 composites have shown excellent performance for the hydrogen evolution reaction (HER) with the Pt NPs exhibiting a volcano-type size effect toward HER activity due to the synergistic effects between the Pt NPs and MoS2.PMID:33616580 | DOI:10.1039/d0cc08091h (Source: Chemical Communications)
Source: Chemical Communications - February 22, 2021 Category: Chemistry Authors: Liang Mei Xiaoping Gao Zhan Gao Qingyong Zhang Xinge Yu Andrey L Rogach Zhiyuan Zeng Source Type: research

Self-sorting of porous Cu < sub > 4 < /sub > L < sub > 2 < /sub > L' < sub > 2 < /sub > metal-organic cages composed of isomerisable ligands
We report the self-sorting of a dynamic combinatorial library (DCL) of metal-organic cages composed of a rotationally isomerisable ligand. Convergence of the DCL occurs upon crystallisation and leads to low-symmetry Cu4L2L'2 cages that display differing porosities based on their overall shape and ligand configuration.PMID:33616581 | DOI:10.1039/d0cc08076d (Source: Chemical Communications)
Source: Chemical Communications - February 22, 2021 Category: Chemistry Authors: Adrian W Markwell-Heys Matthew L Schneider Jenica Marie L Madridejos Gregory F Metha Witold M Bloch Source Type: research

Cross-coupling reactions with esters, aldehydes, and alcohols
Chem Commun (Camb). 2021 Feb 22. doi: 10.1039/d0cc08389e. Online ahead of print.ABSTRACTCross-coupling reactions to form biaryls and π bond addition reactions to prepare substituted carbonyls or alcohols represent two of the most frequently performed families of chemical reactions. Recent progress in catalysis has uncovered substantial overlap between these two seemingly distinct topics. In particular, esters, aldehydes, and alcohols have been shown to act as carbon-based coupling partners in a range of Ni- and Pd-catalyzed reactions to prepare amides, ketones, substituted alcohols, alkanes, and more. These reactions pr...
Source: Chemical Communications - February 22, 2021 Category: Chemistry Authors: Yan-Long Zheng Stephen G Newman Source Type: research

Copper-based single-atom alloys for heterogeneous catalysis
Chem Commun (Camb). 2021 Feb 22. doi: 10.1039/d1cc00062d. Online ahead of print.ABSTRACTHeterogeneous catalysts, as crucial industrial commodities, play an important role in industrial production, especially in energy catalysis. Traditional noble metal catalysts cannot meet the increasing demand. Therefore, the exploration of cost-effective catalysts with high activity and selectivity is important to promote chemical production. Single-atom alloy (SAA) catalysts reduce the use of precious metals compared with traditional catalysts. The unique structure of SAAs, extremely high atom utilization and high catalytic selectivity...
Source: Chemical Communications - February 22, 2021 Category: Chemistry Authors: Fengjuan Qin Wenxing Chen Source Type: research

UV-induced photolysis of polyurethanes
Chem Commun (Camb). 2021 Feb 22. doi: 10.1039/d1cc00124h. Online ahead of print.ABSTRACTWaste production associated with the use of non-degradable materials in packaging is a growing cause of environmental concern, with the polyurethane (PU) class being notorious for their lack of degradability. Herein, we incorporate photosensitive ortho-Nitrobenzyl units into PUs to achieve controllable photodegradability. We performed their photolysis in solution and thin films which can inform the design of degradable adhesives.PMID:33616594 | DOI:10.1039/d1cc00124h (Source: Chemical Communications)
Source: Chemical Communications - February 22, 2021 Category: Chemistry Authors: Charlotte Petit Julian Bachmann Lukas Michalek Yohann Catel Eva Blasco James P Blinco Andreas-N Unterreiner Christopher Barner-Kowollik Source Type: research

Metal-responsive reversible binding of triplex-forming oligonucleotides with 5-hydroxyuracil nucleobases
Chem Commun (Camb). 2021 Feb 22. doi: 10.1039/d1cc00553g. Online ahead of print.ABSTRACTMetal-responsive triplex-forming oligonucleotides (TFOs) were synthesised by incorporating 5-hydroxyuracil (UOH) nucleobases as metal recognition sites. Binding of the UOH-containing TFO to the target natural DNA duplexes was reversibly regulated by the addition and removal of GdIII ions under isothermal conditions.PMID:33616595 | DOI:10.1039/d1cc00553g (Source: Chemical Communications)
Source: Chemical Communications - February 22, 2021 Category: Chemistry Authors: Kotaro Nishiyama Keita Mori Yusuke Takezawa Mitsuhiko Shionoya Source Type: research

Electrochemical rearrangement protocols towards the construction of diverse molecular frameworks
Chem Commun (Camb). 2021 Feb 22. doi: 10.1039/d1cc00116g. Online ahead of print.ABSTRACTRearrangement reactions constitute a critical facet of synthetic organic chemistry and demonstrate an attractive way to take advantage of existing structures to access various important molecular frameworks. Electroorganic chemistry has emerged as an environmentally benign approach to carry out organic transformations by directly employing an electric current and avoids the use of stoichiometric chemical oxidants. The last few years have witnessed a resurgence of electroorganic chemistry that has promoted a renaissance of interest in th...
Source: Chemical Communications - February 22, 2021 Category: Chemistry Authors: Debarshi Saha Irshad Maajid Taily Rakesh Kumar Prabal Banerjee Source Type: research

A cyclic manipulation of cage isomers < em > via < /em > anion exchange and thermal isomerism
Chem Commun (Camb). 2021 Feb 22. doi: 10.1039/d0cc08303h. Online ahead of print.ABSTRACTA cyclic manipulation of peanut cage isomers has been achieved via anion exchange and unusual cage isomerism.PMID:33617614 | DOI:10.1039/d0cc08303h (Source: Chemical Communications)
Source: Chemical Communications - February 22, 2021 Category: Chemistry Authors: Seonghyeon Park Dongwon Kim Doheon Kim Dongwook Kim Ok-Sang Jung Source Type: research

Understanding active sites in molecular (photo)electrocatalysis through complementary vibrational spectroelectrochemistry
Chem Commun (Camb). 2021 Feb 19. doi: 10.1039/d0cc07376h. Online ahead of print.ABSTRACTSynthetic molecular (photo)electrocatalysts have been intensively studied due to their capability to drive key energy conversion reactions. In order to advance their potential through rational development, an in-depth mechanistic understanding of the catalytic reactions is required. In this article, we highlight in situ vibrational spectro-electrochemistry, specifically, confocal Raman and infrared absorption spectroscopy, as a highly capable method for obtaining profound insights into the structure and reactivity of electrode-immobilis...
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Khoa H Ly Inez M Weidinger Source Type: research

Multicharge β-cyclodextrin supramolecular assembly for ATP capture and drug release
Chem Commun (Camb). 2021 Feb 19. doi: 10.1039/d1cc00292a. Online ahead of print.ABSTRACTA hyaluronidase-responsive polysaccharide supramolecular assembly was constructed from an amphiphilic β-cyclodextrin bearing seven hexylimidazolium units (AMCD), adamantyl-grafted hyaluronic acid, and chlorambucil, which showed specific cancer cell targeting and controlled drug release abilities. Interestingly, ternary supramolecular assembly can disassemble in the presence of hyaluronidase, and the released AMCD can assemble with ATP to form a stable 1 : 1 complex, which enhanced the efficacy of chlorambucil on cancer chemotherapy...
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Changhui Chen Yong Chen Xianyin Dai Jingjing Li Shanshan Jia Shuaipeng Wang Yu Liu Source Type: research

Stuffed pumpkins: mechanochemical synthesis of host-guest complexes with cucurbit[7]uril
Chem Commun (Camb). 2021 Feb 19. doi: 10.1039/d1cc00240f. Online ahead of print.ABSTRACTSolvent-free mechanochemical synthesis (ball-milling) was used to prepare inclusion complexes with cucurbit[7]uril and four model guest molecules (adamantane, adamantyl-1-amine hydrochloride, toluidine hydrochloride, and p-phenylenediamine dihydrochloride). Successful formation of individual inclusions was independently confirmed by one- and two-dimensional solid-state NMR techniques and differential scanning calorimetry. Mechanochemical synthesis represents an alternative path towards new types of cucurbit[n]uril/guest inclusion comple...
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Martin Dra čínský Carina Santos Hurtado Eric Masson Ji ří Kaleta Source Type: research

Chorismate- and isochorismate converting enzymes: versatile catalysts acting on an important metabolic node
Chem Commun (Camb). 2021 Feb 19. doi: 10.1039/d0cc08078k. Online ahead of print.ABSTRACTChorismate and isochorismate represent an important branching point connecting primary and secondary metabolism in bacteria, fungi, archaea and plants. Chorismate- and isochorismate-converting enzymes are potential targets for new bioactive compounds, as well as valuable biocatalysts for the in vivo and in vitro synthesis of fine chemicals. The diversity of the products of chorismate- and isochorismate-converting enzymes is reflected in the enzymatic three-dimensional structures and molecular mechanisms. Due to the high reactivity of ch...
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Florian Hubrich Michael M üller Jennifer N Andexer Source Type: research

A cerium oxide@metal-organic framework nanoenzyme as a tandem catalyst for enhanced photodynamic therapy
Chem Commun (Camb). 2021 Feb 19. doi: 10.1039/d1cc00001b. Online ahead of print.ABSTRACTAn O2 self-evolving core-shell theranostic nanohybrid was developed by encapsulating a nanoenzyme cerium oxide (CeOx) in a metal-organic framework (MOF). The hybrid reveals a 9-fold higher apoptotic percentage than bare CeOx in a harsh hypoxic microenvironment through tandem homogenous catalysis. Simultaneously, the oxygen-promoted therapeutic efficiency was self-monitored by the hybrid with caspase-3 activation, paving the way for MOF-functionalized nanoenzymes in theranostics.PMID:33605969 | DOI:10.1039/d1cc00001b (Source: Chemical Communications)
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Jintong Liu Lin Yao Ye Wei Hong Xiong Tianrui Liu Hong Yang Jianping Lei Source Type: research

"Give me five" - an amino imidazoline-2-imine ligand stabilises the first neutral five-membered cyclic triel(I) carbenoides
We present the first cyclic five-membered triel(i) carbenoides E(AmIm) for E = Ga, In, Tl; AmIm = amido imidazoline-2-imine, which fill the current gap between four- and six-membered triel(i) carbenoides supported by HGiso and HNacNac. Ga(AmIm) can act as a strong σ-donor ligand in transition metal complexes, while the intermediacy of the Al(i) carbenoide Al(AmIm) is rationalised based on the isolation of an Al(iii) insertion product.PMID:33605974 | DOI:10.1039/d1cc00010a (Source: Chemical Communications)
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Lars Denker Bartosz Trzaskowski Ren é Frank Source Type: research

Photoinduced intramolecular carbosulfonylation of alkynes: access to sulfone-containing dibenzazepines from sulfur dioxide
Chem Commun (Camb). 2021 Feb 19. doi: 10.1039/d0cc07927h. Online ahead of print.ABSTRACTA photoinduced three-component reaction of N-benzyl-N-(2-ethynylaryl)amides, sulfur dioxide and aryldiazonium tetrafluoroborates is developed, providing an efficient and straightforward approach for the synthesis of diverse vinylsulfonylated dibenzazepine derivatives in moderate to good yields under mild conditions. This transformation proceeds smoothly at room temperature in the presence of visible light, which shows a wide range of substrate scope with good functional group compatibility. The synthetic utility of this methodology is f...
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Yanfang Yao Ziqing Yin Fu-Sheng He Xuwei Qin Wenlin Xie Jie Wu Source Type: research

Heteroternary cucurbit[8]uril complexes as supramolecular scaffolds for self-assembled bifunctional photoredoxcatalysts
Chem Commun (Camb). 2021 Feb 19. doi: 10.1039/d0cc08025j. Online ahead of print.ABSTRACTThe self-assembly of bifunctional photoredoxcatalysts is reported. A series of photosensitizers and water-reducing catalysts were functionalized with viologen- and naphthol-units, respectively. Subsequent formation of the heteroternary cucurbit[8]uril-viologen-naphthol complexes was used for the constitution of bifunctional photoredoxcatalysts for hydrogen generation.PMID:33606856 | DOI:10.1039/d0cc08025j (Source: Chemical Communications)
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Fabian Lutz Nerea Lorenzo-Parodi Torsten C Schmidt Jochen Niemeyer Source Type: research

pH-Dependent ion permeability control of a modified amphotericin B channel through metal complexation
Chem Commun (Camb). 2021 Feb 19. doi: 10.1039/d0cc08368b. Online ahead of print.ABSTRACTAmphotericin B incorporating 2,2'-bipyridine (bpy-AmB) forms a membrane channel exhibiting pH-dependent Ca2+ ion permeability with a selective response to Cu2+ ions. The coordination structure at bpy sites depends on the pH and metal ions can control the association state of bpy-AmB in the membrane.PMID:33606865 | DOI:10.1039/d0cc08368b (Source: Chemical Communications)
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Tomomi Koshiyama Yuki Inoue Sana Asada Koki Kawahara Shogo Ide Kazuma Yasuhara Masaaki Ohba Source Type: research

A high-stability biphasic layered cathode for sodium-ion batteries
Chem Commun (Camb). 2021 Feb 19. doi: 10.1039/d0cc08302j. Online ahead of print.ABSTRACTA novel biphasic layered Na0.62Ni0.33Mn0.62Sb0.05O2 cathode is introduced which can be easily synthesized via a solid-state reaction method. Compared with its monophasic counterpart Na0.67Ni0.33Mn0.67O2, biphasic Na0.62Ni0.33Mn0.62Sb0.05O2 displays a smoother (dis)charge profile, superior rate capability along with splendid cycling performance. Structural and kinetic studies respectively demonstrate extremely small volume strain and rapid charge transfer during the electrochemical process.PMID:33606867 | DOI:10.1039/d0cc08302j (Source: ...
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Yue Liang Hang Xu Kezhu Jiang Jingjing Bian Shaohua Guo Haoshen Zhou Source Type: research

Understanding active sites in molecular (photo)electrocatalysis through complementary vibrational spectroelectrochemistry.
Abstract Synthetic molecular (photo)electrocatalysts have been intensively studied due to their capability to drive key energy conversion reactions. In order to advance their potential through rational development, an in-depth mechanistic understanding of the catalytic reactions is required. In this article, we highlight in situ vibrational spectro-electrochemistry, specifically, confocal Raman and infrared absorption spectroscopy, as a highly capable method for obtaining profound insights into the structure and reactivity of electrode-immobilised molecular catalytic systems. Commonly employed experimental configu...
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Ly KH, Weidinger IM Tags: Chem Commun (Camb) Source Type: research

Multicharge β-cyclodextrin supramolecular assembly for ATP capture and drug release.
Multicharge β-cyclodextrin supramolecular assembly for ATP capture and drug release. Chem Commun (Camb). 2021 Feb 19;: Authors: Chen C, Chen Y, Dai X, Li J, Jia S, Wang S, Liu Y Abstract A hyaluronidase-responsive polysaccharide supramolecular assembly was constructed from an amphiphilic β-cyclodextrin bearing seven hexylimidazolium units (AMCD), adamantyl-grafted hyaluronic acid, and chlorambucil, which showed specific cancer cell targeting and controlled drug release abilities. Interestingly, ternary supramolecular assembly can disassemble in the presence of hyaluronidase, and the released...
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Chen C, Chen Y, Dai X, Li J, Jia S, Wang S, Liu Y Tags: Chem Commun (Camb) Source Type: research

Stuffed pumpkins: mechanochemical synthesis of host-guest complexes with cucurbit[7]uril.
E, Kaleta J Abstract Solvent-free mechanochemical synthesis (ball-milling) was used to prepare inclusion complexes with cucurbit[7]uril and four model guest molecules (adamantane, adamantyl-1-amine hydrochloride, toluidine hydrochloride, and p-phenylenediamine dihydrochloride). Successful formation of individual inclusions was independently confirmed by one- and two-dimensional solid-state NMR techniques and differential scanning calorimetry. Mechanochemical synthesis represents an alternative path towards new types of cucurbit[n]uril/guest inclusion complexes that are not accessible due to limited solubility of t...
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Dračínský M, Hurtado CS, Masson E, Kaleta J Tags: Chem Commun (Camb) Source Type: research

Chorismate- and isochorismate converting enzymes: versatile catalysts acting on an important metabolic node.
JN Abstract Chorismate and isochorismate represent an important branching point connecting primary and secondary metabolism in bacteria, fungi, archaea and plants. Chorismate- and isochorismate-converting enzymes are potential targets for new bioactive compounds, as well as valuable biocatalysts for the in vivo and in vitro synthesis of fine chemicals. The diversity of the products of chorismate- and isochorismate-converting enzymes is reflected in the enzymatic three-dimensional structures and molecular mechanisms. Due to the high reactivity of chorismate and its derivatives, these enzymes have evolved to be acc...
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Hubrich F, Müller M, Andexer JN Tags: Chem Commun (Camb) Source Type: research

A cerium oxide@metal-organic framework nanoenzyme as a tandem catalyst for enhanced photodynamic therapy.
Abstract An O2 self-evolving core-shell theranostic nanohybrid was developed by encapsulating a nanoenzyme cerium oxide (CeOx) in a metal-organic framework (MOF). The hybrid reveals a 9-fold higher apoptotic percentage than bare CeOx in a harsh hypoxic microenvironment through tandem homogenous catalysis. Simultaneously, the oxygen-promoted therapeutic efficiency was self-monitored by the hybrid with caspase-3 activation, paving the way for MOF-functionalized nanoenzymes in theranostics. PMID: 33605969 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Liu J, Ye LY, Xiong WH, Liu T, Yang H, Lei J Tags: Chem Commun (Camb) Source Type: research

"Give me five" - an amino imidazoline-2-imine ligand stabilises the first neutral five-membered cyclic triel(I) carbenoides.
We present the first cyclic five-membered triel(i) carbenoides E(AmIm) for E = Ga, In, Tl; AmIm = amido imidazoline-2-imine, which fill the current gap between four- and six-membered triel(i) carbenoides supported by HGiso and HNacNac. Ga(AmIm) can act as a strong σ-donor ligand in transition metal complexes, while the intermediacy of the Al(i) carbenoide Al(AmIm) is rationalised based on the isolation of an Al(iii) insertion product. PMID: 33605974 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Denker L, Trzaskowski B, Frank R Tags: Chem Commun (Camb) Source Type: research

Photoinduced intramolecular carbosulfonylation of alkynes: access to sulfone-containing dibenzazepines from sulfur dioxide.
Abstract A photoinduced three-component reaction of N-benzyl-N-(2-ethynylaryl)amides, sulfur dioxide and aryldiazonium tetrafluoroborates is developed, providing an efficient and straightforward approach for the synthesis of diverse vinylsulfonylated dibenzazepine derivatives in moderate to good yields under mild conditions. This transformation proceeds smoothly at room temperature in the presence of visible light, which shows a wide range of substrate scope with good functional group compatibility. The synthetic utility of this methodology is further demonstrated through Suzuki coupling. Mechanistic studies show ...
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Yao Y, Yin Z, He FS, Qin X, Xie W, Wu J Tags: Chem Commun (Camb) Source Type: research

Heteroternary cucurbit[8]uril complexes as supramolecular scaffolds for self-assembled bifunctional photoredoxcatalysts.
Abstract The self-assembly of bifunctional photoredoxcatalysts is reported. A series of photosensitizers and water-reducing catalysts were functionalized with viologen- and naphthol-units, respectively. Subsequent formation of the heteroternary cucurbit[8]uril-viologen-naphthol complexes was used for the constitution of bifunctional photoredoxcatalysts for hydrogen generation. PMID: 33606856 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Lutz F, Lorenzo-Parodi N, Schmidt TC, Niemeyer J Tags: Chem Commun (Camb) Source Type: research