Enantioselective conjugate addition of an α,α-dithioacetonitrile with nitroalkenes using chiral bis(imidazoline)-Pd complexes.
Enantioselective conjugate addition of an α,α-dithioacetonitrile with nitroalkenes using chiral bis(imidazoline)-Pd complexes. Chem Commun (Camb). 2019 Apr 18;: Authors: Nakamura S, Tokunaga A, Saito H, Kondo M Abstract The enantioselective conjugate addition reaction of an α,α-dithioacetonitrile with nitroalkenes was catalysed by chiral bis(imidazoline)-palladium pincer-type complexes. The reaction was applicable to various nitroalkenes to afford products in good yield with high enantioselectivity. The obtained products can be converted to γ-lactam and biologically activ...
Source: Chemical Communications - April 18, 2019 Category: Chemistry Authors: Nakamura S, Tokunaga A, Saito H, Kondo M Tags: Chem Commun (Camb) Source Type: research

Open-shell jellium aromaticity in metal clusters.
ve; M Abstract The 2N2 + 2N + 1 with S = N + 1/2 rule represented the extension to open-shell spherical compounds of the 2(N + 1)2 Hirsch rule for spherical aromatic species. In this work, we provide evidence that the jellium model with its magic numbers can also be extended to open-shell half-filled systems. PMID: 30997449 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 18, 2019 Category: Chemistry Authors: Poater J, Solà M Tags: Chem Commun (Camb) Source Type: research

Tandem catalysis by ultrathin metal-organic nanosheets formed through post-synthetic functionalisation of a layered framework.
Abstract Covalent post-synthetic functionalisation of layered metal-organic frameworks is demonstrated as a new approach to forming ultrathin nanosheets for use in catalysis. An aminoterephthalate framework was partially functionalised with sulfonate chains and exfoliated to form predominantly monolayer nanosheets able to catalyse a two-step acid-base reaction in one pot. PMID: 30997453 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 18, 2019 Category: Chemistry Authors: Nicks J, Zhang J, Foster JA Tags: Chem Commun (Camb) Source Type: research

DNA-mediated reversible capture and release of circulating tumor cells with a multivalent dual-specific aptamer coating network.
Abstract DNA-triggered reversible isolation and recovery of circulating tumor cells (CTCs) is presented based on a multivalent dual-specific aptamer-tethered rolling circle amplification (MA-RCA) network. The multivalent binding sites endow the MA-RCA network with a strong binding ability towards CTCs, and the repeated cell capture/release processes are also actualized in a noninvasive manner. PMID: 30997454 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 18, 2019 Category: Chemistry Authors: Lin Y, Jiang L, Huang Y, Yang Y, He Y, Lu C, Yang H Tags: Chem Commun (Camb) Source Type: research

Optimizing electron transfer from CdSe QDs to hydrogenase for photocatalytic H2 production.
Abstract A series of viologen related redox mediators of varying reduction potential has been characterized and their utility as electron shuttles between CdSe quantum dots and hydrogenase enzyme has been demonstrated. Tuning the mediator LUMO energy optimizes the performance of this hybrid photocatalytic system by balancing electron transfer rates of the shuttle. PMID: 30997456 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 18, 2019 Category: Chemistry Authors: Sanchez MLK, Wu CH, Adams MWW, Dyer RB Tags: Chem Commun (Camb) Source Type: research

Stable Sn2+ doped FAPbI3 nanocrystals for near-infrared LEDs.
Abstract Herein, we report Sn2+ doping in FAPbI3 NCs to stabilize the α-phase, while using propionic acid as a co-ligand. The Sn2+ doping enhances the emission quantum yield from 35% to 63% and dramatically improves the colloidal and phase stability. Also, we demonstrated the use of Sn doped FAPbI3 NCs in near-infrared (NIR) LEDs. PMID: 30997459 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 18, 2019 Category: Chemistry Authors: Begum R, Chin XY, Li M, Damodaran B, Sum TC, Mhaisalkar S, Mathews N Tags: Chem Commun (Camb) Source Type: research

pH-Dependent structure of water-exposed surfaces of CdSe quantum dots.
Abstract Increasing negative charge density at the surfaces of CdSe quantum dots (QDs) effects a bathochromic shift of their ground state optical spectra with increasing pH due to electrostatic and chemical modifications at the QD surface. These modifications are enabled by weakly-bound ligands that expose the surface to the aqueous environment. PMID: 30997460 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 18, 2019 Category: Chemistry Authors: Westmoreland DE, Nap RJ, Arcudi F, Szleifer I, Weiss EA Tags: Chem Commun (Camb) Source Type: research

Liquid crystalline microspheres of azobenzene amphiphiles formed by thermally induced pH changes in binary water-hydrolytic ionic liquid media.
Abstract Anionic azobenzene-containing bilayered membranes dispersed in binary water-ionic liquid (IL) media undergo proton-responsive transformation into liquid crystalline microspheres (LCMs). This transformation was induced by protons released by the heat-induced hydrolysis of tetrafluoroborate ions in the ILs. This work demonstrates the first beneficial use of hydrolysis-susceptible ILs in chemistry. PMID: 30997907 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 18, 2019 Category: Chemistry Authors: Kang TS, Morikawa MA, Kimizuka N Tags: Chem Commun (Camb) Source Type: research

Crystal melting and glass formation in copper thiocyanate based coordination polymers.
Abstract Crystal melting and glass formation of coordination polymers (CPs) and metal-organic frameworks (MOFs) are rare thermal events. To expand the library of melting CP/MOFs, we utilized anti-crystal engineering in ionic liquids to construct CPs. A combination of Cu+ and 4,4'-bipyridin-1-ium derivatives afforded four melting CPs showing stable liquid and glassy states. PMID: 30997908 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 18, 2019 Category: Chemistry Authors: Nagarkar SS, Kurasho H, Duong NT, Nishiyama Y, Kitagawa S, Horike S Tags: Chem Commun (Camb) Source Type: research

Catalysis: energy is the measure of all things.
Abstract Is there any place in the extremely well-established field of catalytic kinetics for new interpretations or novel models that can change the basic doctrines and viewpoints of catalytic cycles? Since the first introduction of the energy span model, we started to believe that indeed there is. Herein we will evaluate from mathematical, physical and applied perspectives the advantages in using the energy representation for the depiction of the kinetics of catalysis, compared to the usual rate constant representation. We will discuss many concepts such as the energy span, the determining states, the determinin...
Source: Chemical Communications - April 18, 2019 Category: Chemistry Authors: Solel E, Tarannam N, Kozuch S Tags: Chem Commun (Camb) Source Type: research

Light-activated "cycle-reversible intramolecular charge transfer" fluorescent probe: monitoring of pHi trace change induced by UV light in programmed cell death.
Light-activated "cycle-reversible intramolecular charge transfer" fluorescent probe: monitoring of pHi trace change induced by UV light in programmed cell death. Chem Commun (Camb). 2019 Apr 17;: Authors: Jiang T, Wang X, Wang G, Wang Y, Wang K, Xuan X, Chen C, Jiang K, Zhang H Abstract Under the synergistic effects of protonation and deprotonation, a light-activated fluorescent probe (UV-SP) exhibited "cycle-reversible intramolecular charge transfer (ICT)" for different pH after activation by UV light, resulting in emission of multiple ratio fluorescent signals (FI563/FI595 and FI...
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Jiang T, Wang X, Wang G, Wang Y, Wang K, Xuan X, Chen C, Jiang K, Zhang H Tags: Chem Commun (Camb) Source Type: research

Dihalogen-bridged NHC-palladium(i) dimers: synthesis, characterisation and applications in cross-coupling reactions.
n LJ Abstract A di-iodo-bridged PdI dimer bearing an N-heterocyclic carbene ligand was made accessible via the reduction of [(IPr)PdI2]2 in basic methanol solution. The structural features of [(IPr)PdI]2 were explored by single-crystal X-ray analysis. It was found to be a convenient one-component precatalyst with high activity in Suzuki-Miyaura, Buchwald-Hartwig, and Sonogashira reactions. PMID: 30993276 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Pirkl N, Del Grosso A, Mallick B, Doppiu A, Gooßen LJ Tags: Chem Commun (Camb) Source Type: research

Iodine-doped sulfurized polyacrylonitrile with enhanced electrochemical performance for room-temperature sodium/potassium sulfur batteries.
Abstract Iodine-doped sulfurized polyacrylonitrile (I-S@pPAN) is reported for room-temperature sodium sulfur (RT-Na/S) and potassium sulfur (RT-K/S) batteries operated in ester-based electrolytes. It delivers an unprecedented capacity of 994 mA h g-1 at 2C (3350 mA g-1) for the RT-Na/S battery, whilst a reversible capacity of 947 mA h g-1 at 0.1C for the RT-K/S battery. PMID: 30993277 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Ma S, Zuo P, Zhang H, Yu Z, Cui C, He M, Yin G Tags: Chem Commun (Camb) Source Type: research

Photocontrolled endogenous reactive oxygen species (ROS) generation.
Abstract A cell-permeable small molecule for light-triggered generation of endogenous reactive oxygen species (ROS) is reported. PMID: 30993280 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Sharma AK, Singh H, Chakrapani H Tags: Chem Commun (Camb) Source Type: research

A multifunctional persistent luminescent nanoprobe for imaging guided dual-stimulus responsive and triple-synergistic therapy of drug resistant tumor cells.
We report the design and fabrication of a multifunctional persistent luminescent nanoprobe for imaging guided dual-stimulus responsive and triple-synergistic therapy of drug resistant tumor. The integration of the dual-stimulus of an acidic microenvironment and laser irradiation with the triple-synergistic therapy of doxorubicin, photothermal and siRNA offers excellent therapeutic performance for drug resistant tumor cells with high specificity and little side effects. PMID: 30993283 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Su FX, Zhao X, Dai C, Li YJ, Yang CX, Yan XP Tags: Chem Commun (Camb) Source Type: research

Enantioselective iridium catalyzed α-alkylation of azlactones by a tandem asymmetric allylic alkylation/aza-Cope rearrangement.
Enantioselective iridium catalyzed α-alkylation of azlactones by a tandem asymmetric allylic alkylation/aza-Cope rearrangement. Chem Commun (Camb). 2019 Apr 17;: Authors: Bai XD, Zhang QF, He Y Abstract The development of an iridium catalyzed enantioselective α-alkylation of azlactones has been described. The reaction provides rapid access to a wide range of enantio-enriched quaternary carbon center allylated 2,4-diaryloxazol-5(2H)-ones in excellent yields with high enantioselectivities. The transformation was achieved through a tandem allylic alkylation/aza-Cope rearrangement, affording t...
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Bai XD, Zhang QF, He Y Tags: Chem Commun (Camb) Source Type: research

Electrocatalytic N2-to-NH3 conversion with high faradaic efficiency enabled using a Bi nanosheet array.
Abstract Electrocatalytic N2 reduction represents a promising alternative to the conventional Haber-Bosch process for ambient N2-to-NH3 fixation, but it is severely challenged by competitive hydrogen evolution, which limits the current efficiency for NH3 formation. In this work, a nanosheet array of metallic Bi, an environmentally benign elemental substance previously predicted theoretically to have low hydrogen-evolving activity, is proposed as a superior catalyst for N2 reduction electrocatalysis. Electrochemical tests show that the Bi nanosheet array on Cu foil as a stable 3D catalyst electrode achieves a high ...
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Zhang R, Ji L, Kong W, Wang H, Zhao R, Chen H, Li T, Li B, Luo Y, Sun X Tags: Chem Commun (Camb) Source Type: research

Elucidating the mechanism of the structure-dependent enzymatic activity of Fe-N/C oxidase mimics.
Abstract Herein, we develop an Fe-N/C-CNT nanomaterial with Fe-N3 units as a paradigm for excellent oxidase mimics by theoretical prediction and experimental implementation. The mechanism of the structure-dependent enzymatic activity is systematically investigated and elucidated from the perspective of the different configurations of M-Nx models (x = 0, 3, 4, and 5; M = Fe, Co, and Ni). PMID: 30993298 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Wang Y, Zhang Z, Jia G, Zheng L, Zhao J, Cui X Tags: Chem Commun (Camb) Source Type: research

Efficient synthesis and enzymatic extension of an N-GlcNAz asparagine building block.
Abstract N-Azidoacetyl-d-glucosamine (GlcNAz) is a particularly useful tool in chemical biology as the azide is a metabolically stable yet accessible handle within biological systems. Herein, we report a practical synthesis of FmocAsn(N-Ac3GlcNAz)OH, a building block for solid phase peptide synthesis (SPPS). Protecting group manipulations are minimised by taking advantage of the inherent chemoselectivity of phosphine-mediated azide reduction, and the resulting glycosyl amine is employed directly in the opening of Fmoc protected aspartic anhydride. We show potential application of the building block by establishing...
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Marqvorsen MHS, Paramasivam S, Doelman W, Fairbanks AJ, van Kasteren SI Tags: Chem Commun (Camb) Source Type: research

Copper-catalyzed ring-opening C(sp3)-N coupling of cycloketone oxime esters: access to 1 °, 2° and 3° alkyl amines.
Copper-catalyzed ring-opening C(sp3)-N coupling of cycloketone oxime esters: access to 1°, 2° and 3° alkyl amines. Chem Commun (Camb). 2019 Apr 17;: Authors: Tian L, Gao S, Wang R, Li Y, Tang C, Shi L, Fu J Abstract A novel copper-catalyzed C(sp3)-N coupling of cycloketone oxime esters with nitrogen nucleophiles has been realized. All of the N-aryl/alkylanilines, anilines and benzophenone imine could be employed in this protocol to produce a variety of 1°, 2° and 3° alkyl amines in one or two steps. These resultant cyano-containing alkyl amines were proven to be versatile synth...
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Tian L, Gao S, Wang R, Li Y, Tang C, Shi L, Fu J Tags: Chem Commun (Camb) Source Type: research

Nickel phthalocyanine as an excellent hole-transport material in inverted planar perovskite solar cells.
Abstract Pristine nickel phthalocyanine (NiPc) was introduced as a hole transporting material (HTM) in inverted planar perovskite solar cells (PSCs) for the first time. A power conversion efficiency of 14.3% was achieved, outperforming the values obtained in the solar cells based on the CuPc HTM, which is a typical representative of metal phthalocyanine based HTMs. Moreover, inverted planar PSCs based on NiPc HTMs show a very weak hysteresis behavior. PMID: 30994129 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Haider M, Zhen C, Wu T, Wu J, Jia C, Liu G, Cheng HM Tags: Chem Commun (Camb) Source Type: research

Supramolecular switching of the self-assembly of cyclic peptide-polymer conjugates via host-guest chemistry.
Abstract A supramolecular strategy of switching the self-assembly of cyclic peptide-polymer conjugates using host-guest chemistry is proposed. The formation of tubular supramolecular polymers based on cyclic peptide-polymer conjugates can be controlled by reversibly attaching cucurbit[7]uril onto the cyclic peptide via host-guest interactions. PMID: 30994130 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Song Q, Yang J, Rho JY, Perrier S Tags: Chem Commun (Camb) Source Type: research

Probing the photovoltaic properties of Ga-doped CdS-Cu2S core-shell heterostructured nanowire devices.
This study demonstrates the possibility of modulating not only the properties of CdS NWs through the incorporation of dopant Ga atoms but also the photovoltaic properties of Cu2S-CdS p-n heterostructured NW devices, paving the way for the exploitation of nanostructures within optoelectronics. PMID: 30994633 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Lu MY, Hong MH, Ruan YM, Lu MP Tags: Chem Commun (Camb) Source Type: research

Visible-light-mediated guest trapping in a photosensitizing porous coordination network: metal-free C-C bond-forming modification of metal-organic frameworks for aqueous-phase herbicide adsorption.
Abstract A series of furan/thiophene-derived Cr-MIL-101s were obtained via visible-light-mediated C-C bond-forming catalysis within photosensitizing porous materials. The guest trapping process was achieved under very mild and metal-free conditions, affording newly functionalized MOFs with more π-π stacking, hydrogen bonding properties and excellent adsorption capacity in removing herbicides from aquatic environments. PMID: 30994647 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Yang Y, Che J, Wang B, Wu Y, Chen B, Gao L, Dong X, Zhao J Tags: Chem Commun (Camb) Source Type: research

Mapping aldehydic load in vivo by positron emission tomography with [18F]NA3BF3.
ler A Abstract A new radiotracer, [18F]NA3BF3, capable of rapid, stable, and catalyst-free complexation of aldehydes in vivo is reported. [18F]NA3BF3 was shown to bind aldehydes in live subjects using locally administered aldehyde-presenting microparticles, and was then applied to mapping aldehydic load in a mouse model of sepsis. [18F]NA3BF3 may enable the direct investigation of the chemical biology of aldehydes in living subjects, and may open avenues for the adoption of endogenous aldehydic load as an imaging biomarker of inflammatory pathology. PMID: 30994648 [PubMed - as supplied by publisher] (Source: ...
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Kirby A, Suchý M, Brouwer A, Shuhendler A Tags: Chem Commun (Camb) Source Type: research

A rapidly self-assembling soft-brush DNA hydrogel based on RCA products.
Abstract A rapid self-assembly strategy was developed for fabricating a novel soft-brush DNA hydrogel in one minute by introducing a pair of L-type probes into the RCA products. The L-type probes with universality achieved a controllable size and morphology of the DNA hydrogel, providing deeper insight into variability and probability in functional biomaterials. PMID: 30994649 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Song H, Zhang Y, Cheng P, Chen X, Luo Y, Xu W Tags: Chem Commun (Camb) Source Type: research

Stable gold graphitic nanocapsule doped hydrogels for efficient photothermal antibacterial applications.
Abstract Herein, we have fabricated gold nanorod graphitic nanocapsule (AuNR@G) doped poly(vinyl alcohol) (PVA)/chitosan (CS) hydrogels, which possessed highly efficient and stable photothermal antibacterial properties for both Gram-negative E. coli and Gram-positive S. aureus under the irradiation of a near-infrared laser. PMID: 30994651 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Xu ML, Guan LY, Li SK, Chen L, Chen Z Tags: Chem Commun (Camb) Source Type: research

Catalytic hydrazine disproportionation mediated by a thiolate-bridged VFe complex.
Abstract A heterobimetallic VFe complex is demonstrated to catalyse hydrazine disproportionation with yields of up to 1073 equivalents of NH3 per catalyst, comparable to the highest turnover known for any molecular catalyst. Notably, the heterobimetallic complex is appreciably more active than monometallic analogues of the V and Fe sites, suggesting that bimetallic cooperativity may facilitate the observed catalysis. PMID: 30994653 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Gu NX, Ung G, Peters JC Tags: Chem Commun (Camb) Source Type: research

Graphene oxide catalyzed ketone α-alkylation with alkenes: enhancement of graphene oxide activity by hydrogen bonding.
We report the first ketone-alkylation using olefins and alcohols as simple alkylating agents catalyzed by graphene oxide. Extensive studies of the graphene surface suggest a pathway involving dual activation of both coupling partners. Notably, we show that polar functional groups have a stabilizing effect on the GO surface, which results in a net enhancement of the catalytic activity. The method represents the first alkylation of carbonyl compounds using graphenes, which opens the door for the development of an array of protocols for ketone functionalization employing common carbonyl building blocks and readily available g...
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Meng G, Patel M, Luo F, Li Q, Flach C, Mendelsohn R, Garfunkel E, He H, Szostak M Tags: Chem Commun (Camb) Source Type: research

Multiple functional groups in UiO-66 improve chemical warfare agent simulant degradation.
Abstract A library of 26 mixed ligand UiO-66 analogs was synthesized, characterized, and screened for catalytic degradation of the chemical warfare agent (CWA) simulant dimethyl 4-nitrophenylphosphate (DMNP). The MOFs were screened and compared to physical mixtures of the same single component MOFs. Several of the MOFs display higher catalytic activity than the parent UiO-66 and other single ligand UiO-66 analogues. PMID: 30994655 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Kalaj M, Palomba JM, Bentz KC, Cohen SM Tags: Chem Commun (Camb) Source Type: research

Heavy-atom-free amorphous materials with facile preparation and efficient room-temperature phosphorescence emission.
Abstract Amorphous pure organic room-temperature phosphorescent small molecules without heavy atoms, based on the intermolecular hydrogen bonding network for the immobilization of luminophores, were designed and facilely prepared via modification of heavy-atom-free luminophores onto β-cyclodextrin. PMID: 30994657 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Zhao C, Jin Y, Wang J, Cao X, Ma X, Tian H Tags: Chem Commun (Camb) Source Type: research

Preferential synthesis of ethanol from syngas via dimethyl oxalate hydrogenation over an integrated catalyst.
Abstract An integrated catalyst that contains Fe5C2 and CuZnO-SiO2 with a dual-bed configuration was designed for the preferential synthesis of ethanol via dimethyl oxalate hydrogenation. The cooperation of the two catalyst components remarkably inhibited the formation of various byproducts, resulting in a significantly high ethanol yield of about 98%. PMID: 30994659 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Shang X, Huang H, Han Q, Xu Y, Zhao Y, Wang S, Ma X Tags: Chem Commun (Camb) Source Type: research

Size-controlled DNA-cross-linked hydrogel coated silica nanoparticles served as a ratiometric fluorescent probe for the detection of adenosine triphosphate in living cells.
Abstract Herein, we have designed a ratiometric fluorescent nanoprobe for adenosine triphosphate sensing and imaging in living cells, based on silica nanoparticles and a DNA-functionalized hybrid hydrogel. This ratiometric detecting method could validly avoid false-positive signals. Due to its controllable size, favorable biocompatibility and biostability, the nanohydrogel exhibited high cellular permeability and fast response in living cells. PMID: 30989156 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 16, 2019 Category: Chemistry Authors: Ji X, Wang J, Niu S, Ding C Tags: Chem Commun (Camb) Source Type: research

A two-dimensional crystal formed by pentamers on Au(111).
Abstract A new type of two-dimensional crystal comprising supramolecular pentamers on Au(111) is studied using an ultra-high vacuum low-temperature scanning tunnelling microscope. (2E,4E)-3-Methyl-5-(2,6,6-trimethylcyclohex-1-enyl)penta-2,4-dienoic acid molecules form pentamers through five-fold OH-O hydrogen bonds. In ordered arrays, pentamers interact with each other via van der Waals interactions. The impacts of different annealing temperatures and substrates on the formation of pentamer patterns are systemically investigated. PMID: 30989160 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 16, 2019 Category: Chemistry Authors: Yuan C, Xue N, Zhang X, Zhang Y, Li N, Xue Q, Wu T, Hou S, Wang Y Tags: Chem Commun (Camb) Source Type: research

Hydrogen atom transfer from 1,2- and 1,3-diols to the cumyloxyl radical. The role of structural effects on metal-ion induced C-H bond deactivation.
Abstract Strong C-H bond deactivation toward HAT has been observed in the reactions of the cumyloxyl radical with 1,2- and 1,3-diols, following addition of Li+ and Ca2+. Weaker effects have been observed with Mg2+. The role of the substrate structure and of the metal ion in the formation of Lewis acid-base complexes is discussed. PMID: 30990487 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 16, 2019 Category: Chemistry Authors: Martin T, Salamone M, Bietti M Tags: Chem Commun (Camb) Source Type: research

Covalently functionalized carbon nanoparticles with a chiral Mn-Salen: a new nanocatalyst for enantioselective epoxidation of alkenes.
to GT Abstract A new protocol to obtain carbon nanoparticles (CNPs) covalently functionalized with a chiral Mn-Salen catalyst is described here. The new nanocatalyst (CNPs-Mn-Salen) was tested in the enantioselective epoxidation of some representative alkenes (CN-chromene, 1,2-dihydronaphthalene and cis-β-ethyl styrene), obtaining better enantiomeric excess values than that of the catalyst single molecule, highlighting the role of the nanostructure in the enantioselectivity. PMID: 30990489 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 16, 2019 Category: Chemistry Authors: Zammataro A, Gangemi CMA, Pappalardo A, Toscano RM, Puglisi R, Nicotra G, Fragalà ME, Tuccitto N, Sfrazzetto GT Tags: Chem Commun (Camb) Source Type: research

Design and photoisomerization dynamics of a new family of synthetic 2-stroke light driven molecular rotary motors.
Abstract A new family of light driven molecular rotary motors, which can be synthesized from easily available precursor compounds and which are capable of completing a full 360° revolution by two photoisomerization steps only, is proposed. The non-adiabatic molecular dynamic simulations show that the photoisomerization steps of the motor's working cycle occur on an ultrafast time scale (ca. 200-300 fs), have a very high quantum yield of isomerization (0.91-0.97), and display high selectivity of torsion in the same direction. It is expected that the new motor should remain operational at lower temperatures than...
Source: Chemical Communications - April 16, 2019 Category: Chemistry Authors: Filatov M, Paolino M, Min SK, Choi CH Tags: Chem Commun (Camb) Source Type: research

Superexchange in the fast lane - intramolecular electron transfer in a molecular triad occurs by conformationally gated superexchange.
k B Abstract Photoinduced electron transfer via hopping is generally considered to have a stronger temperature dependence than electron transfer via superexchange. However, in this work, an opposite trend of the temperature dependence is observed. This unexpected result is rationalized by considering the specific geometrical and electronic structure of the Ru-bis(terpyridine) photosensitizer. PMID: 30990492 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 16, 2019 Category: Chemistry Authors: Luo Y, Wächtler M, Barthelmes K, Winter A, Schubert US, Dietzek B Tags: Chem Commun (Camb) Source Type: research

A supramolecular network derived by rotaxane tethering three ureido pyrimidinone groups.
Abstract A supramolecular network and its film were prepared via intermolecular hydrogen bonding of a [2]rotaxane with three ureido pyrimidinone groups. Adding less polar solvents such as CHCl3 to the rotaxane afforded a swollen rotaxane-cross-linked network. The properties of the film obtained by drying were evaluated to characterize it. PMID: 30984928 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 15, 2019 Category: Chemistry Authors: Rao SJ, Nakazono K, Liang X, Nakajima K, Takata T Tags: Chem Commun (Camb) Source Type: research

Target-controlled liposome amplification for versatile nanopore analysis.
Abstract We have reported a versatile nanopore method based on the combination of analyte-controlled liposome signal amplification and the nanopore detection of a reporter molecule, which largely extends the nanopore application range, and easily elevates the nanopore sensitivity to the fM level from the μM level. PMID: 30984931 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 15, 2019 Category: Chemistry Authors: Tian L, Wang Y, Kang XF Tags: Chem Commun (Camb) Source Type: research

Organocatalytic enantioselective direct alkylation of phloroglucinol derivatives: asymmetric total synthesis of (+)-aflatoxin B2.
Abstract The organocatalytic enantioselective Friedel-Crafts alkylation of phloroglucinol derivatives with enals is reported, providing general access to the benzylic chiral centers shown in a variety of phloroglucinol natural products. The synthetic utility is demonstrated by the very concise asymmetric total synthesis of aflatoxins B2. PMID: 30984932 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 15, 2019 Category: Chemistry Authors: Wang Z, Zu L Tags: Chem Commun (Camb) Source Type: research

Strong CPL of achiral AIE-active dyes induced by supramolecular self-assembly in chiral nematic liquid crystals (AIE-N*-LCs).
Abstract Chiral binaphthyl enantiomers (Guest 1) were doped into commercial nematic liquid crystals (N-LCs, Host E7) to form chiral nematic liquid crystals (N*-LCs). The new ternary AIE-N*-LCs prepared by introducing four achiral AIE dyes (Guest 2) into N*-LCs can give rise to strong CPL responses with high luminescence dissymmetry factor (gem) values of up to1.42. PMID: 30984933 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 15, 2019 Category: Chemistry Authors: Li X, Hu W, Wang Y, Quan Y, Cheng Y Tags: Chem Commun (Camb) Source Type: research

Developing chemically modified redox-responsive proteins as smart therapeutics.
Abstract The conditional control of protein function in response to the physiological changes of diseased cells is essential to develop smart protein therapeutics. Herein, we report a redox-responsive chemical modification of a protein by conjugating an intracellular glutathione (GSH)-cleavable ligand, NSA, onto a protein residue. We demonstrated that the NSA conjugation of Ribonuclease A (RNase A) enabled the control of the protein function by GSH in an aqueous solution and living cells, with extended applications for targeted cancer therapy using a lipid nanoparticle-based intracellular protein delivery strategy...
Source: Chemical Communications - April 15, 2019 Category: Chemistry Authors: Tang Q, Wang J, Jiang Y, Zhang M, Chang J, Xu Q, Mao L, Wang M Tags: Chem Commun (Camb) Source Type: research

Dynamic protein hydrogels with reversibly tunable stiffness regulate human lung fibroblast spreading reversibly.
We report the engineering of a protein-based dynamic hydrogel that can be reversibly tuned between stiff and soft states via a redox reaction. When cultured on this hydrogel surface, human lung fibroblasts can dynamically and reversibly change their morphology in response to changes in hydrogel stiffness. PMID: 30984936 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 15, 2019 Category: Chemistry Authors: Fu L, Haage A, Kong N, Tanentzapf G, Li H Tags: Chem Commun (Camb) Source Type: research

Modular design of nanobody-drug conjugates for targeted-delivery of platinum anticancer drugs with an MRI contrast agent.
Abstract A multifunctional nanobody-drug conjugate (NDC) was constructed in this work for the targeted delivery of a platinum prodrug and an MRI contrast agent. The NDC can be specifically internalized into EGFR positive cancer cells, resulting in higher therapeutic effect and lower side-effects relative to cisplatin. The Gd-binding domain enables the in situ detection of the drug distribution in vivo. PMID: 30984937 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 15, 2019 Category: Chemistry Authors: Huang H, Wu T, Shi H, Wu Y, Yang H, Zhong K, Wang Y, Liu Y Tags: Chem Commun (Camb) Source Type: research

Synthesis and controllable self-assembly of 3D amphiphilic organoplatinum(ii) metallacages in water.
Abstract An amphiphilic metallacage with tetragonal prismatic frameworks as a hydrophobic core and pendent tri(ethylene glycol) chains as hydrophilic tails was prepared successfully and showed controllable self-assembly behaviour in water. PMID: 30984940 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 15, 2019 Category: Chemistry Authors: Wang Y, Wang C, Long R, Cao Y, Fan D, Cen M, Cao L, Chen Y, Yao Y Tags: Chem Commun (Camb) Source Type: research

A 'sulfonyl-azide-free' (SAFE) aqueous-phase diazo transfer reaction for parallel and diversity-oriented synthesis.
Abstract Diazo transfer reactions are notoriously associated with the use of potentially explosive sulfonyl azides. The first 'sulfonyl-azide-free' (SAFE) protocol for producing diazo compounds from their active-methylene precursors via the Regitz diazo transfer reaction was developed and has displayed a remarkable substrate scope. It can be applied to generating arrays of diazo compounds for further evolution via combinatorial chemistry and a range of scaffold-generating transformations. PMID: 30985842 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 15, 2019 Category: Chemistry Authors: Dar'in D, Kantin G, Krasavin M Tags: Chem Commun (Camb) Source Type: research

Photooxygenation of 2-propargylfurans: a path to structurally diverse nitrogen-containing 5-membered rings.
uf D Abstract The photooxygenation of 2-propargylfurans enabled access to original nitrogen-containing cyclopentenones and related compounds in a one-pot fashion. By employing readily-available substrates such as furans and amines, we succeeded in achieving a high degree of molecular complexity. Relying on the introduction of an alkyne moiety and tailored substrates, this transformation reveals a new facet for reaction sequences featuring the photooxygenation of furans. PMID: 30976772 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 12, 2019 Category: Chemistry Authors: Marin L, Force G, Guillot R, Gandon V, Schulz E, Lebœuf D Tags: Chem Commun (Camb) Source Type: research

Light-driven catalytic hydrogenation of carbon dioxide at low-pressure by a trinuclear iridium polyhydride complex.
Abstract Low-pressure hydrogenation of carbon dioxide (CO2) has been achieved using a trinuclear iridium hexahydride complex 1. Complex 1 is ligated with a light-absorbing diphosphine ligand to induce light-sensitizing ability. Under photoirradiation, 1 catalyzes CO2 hydrogenation under low-pressure conditions (H2 (5 atm) and CO2 (5 atm)) and at ambient temperature to yield the corresponding formate in high yield. PMID: 30977471 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 12, 2019 Category: Chemistry Authors: Shitaya S, Nomura K, Inagaki A Tags: Chem Commun (Camb) Source Type: research

Simple alkanoyl acylating agents for reversible RNA functionalization and control.
We describe the synthesis and RNA acylation activity of a series of minimalist azidoalkanoyl imidazole reagents, with the aim of functionalizing RNA at 2'-hydroxyl groups at stoichiometric to superstoichiometric levels. We find marked effects of small structural changes on their ability to acylate and be reductively removed, and identify reagents and methods that enable efficient RNA functionalization and control. PMID: 30977472 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 12, 2019 Category: Chemistry Authors: Park HS, Kietrys AM, Kool ET Tags: Chem Commun (Camb) Source Type: research