Supramolecularly modulated carbon-centered radicals: toward selective oxidation from benzyl alcohol to aldehyde

Chem Commun (Camb). 2024 Apr 25. doi: 10.1039/d4cc01240b. Online ahead of print.ABSTRACTThe reactivity of ketyl radicals and benzoyl radicals, two key intermediates of photo-induced oxidation of benzyl alcohol, can be stabilized by the host-guest interaction of the radicals with cucurbit[7]uril. As a result, the selectivity of photo-induced oxidation from benzyl alcohol to aldehyde is significantly improved by diminishing side reactions and inhibiting the generation of carboxylic acid products. This work presents a new route to modulate the reactivity of radical intermediates, enriching the chemistry of supramolecular intermediates and the toolbox of supramolecular catalysis.PMID:38659373 | DOI:10.1039/d4cc01240b

Source: Chemical Communications - April 25, 2024 Category: Chemistry Authors: Xingchen Tang Shan Mei Jiang-Fei Xu Xi Zhang Source Type: research