A two carbon homologation of Friedel-Crafts alkylation enabled by photochemical alkene stitching: modular assembly of cyclolignans

Chem Commun (Camb). 2024 Apr 24. doi: 10.1039/d4cc00957f. Online ahead of print.ABSTRACTHerein we report an efficient two-carbon homologated variant of Friedel-Crafts alkylation via photochemical radical alkene stitching. Readily available feedstock alkenes are used as bridges between photogenerated alkyl radicals and arenes, opening a route to γ-aryl-carbonyls for chemo-divergent access to aryltetralone and γ-lactones, a gateway to 2,7'-cyclolignans.PMID:38656305 | DOI:10.1039/d4cc00957f

Source: Chemical Communications - April 24, 2024 Category: Chemistry Authors: Shyamal Pramanik Apurba Samanta Soumitra Maity Source Type: research