Aetiological molecular identification of sexually transmitted infections that cause urethral discharge syndrome and genital ulcer disease in Brazilian men: a nationwide study
Conclusion
This study provided the acquisition of unprecedented data on the aetiology of UDS and GUD in Brazil, demonstrated the presence of a variety of pathogens in both sample types and reaffirmed the aetiologies known to be most prevalent globally. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Bazzo, M. L., Machado, H. d. M., Martins, J. M., Schörner, M. A., Buss, K., Barazzetti, F. H., Gaspar, P. C., Bigolin, A., Benzaken, A., de Carvalho, S. V. F., Andrade, L. d. F., Ferreira, W. A., Figueiroa, F., Fontana, R. M., da Silva, M. F. d. C Tags: Original research Source Type: research
Can laboratory HIV and infectious syphilis data inform future pre-exposure prophylaxis use in women in Ontario, Canada?
Conclusion
Although it is clinically appropriate to recommend HIV PrEP to women with syphilis, Ontario surveillance data suggest that the population-level impact of this strategy on the HIV epidemic in Ontario would have been modest during this 11-year period. Future studies should explore additional ways of prioritising women for PrEP. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Sadeghi, Y., Nelson, P., Sullivan, A., Allen, V., Hasso, M., Liu, J., Tran, V., Tan, D. H. S. Tags: Open access Short reports Source Type: research
Phenotypic and Immunological Characterization of Patients with Activated PI3K δ Syndrome 1 Presenting with Autoimmunity
ConclusionsThe pathogenic immune phenotype of APDS1 patients included (1) deceased CD3+ T-cell and B-cell counts and increased IgG levels in patients with autoimmunity, (2) an imbalanced T helper cell subset, (3) increased proportions of autoreactive B cells, and (4) distinct autoantibody reactivities in patients with autoimmunity. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - April 18, 2024 Category: Allergy & Immunology Source Type: research
Wide use of broad-spectrum antibiotics in very low birth weight infants with spontaneous focal intestinal perforation —is it really justified?
ConclusionThe use of carbapenems as broad-spectrum antimicrobials agents might not be justified in most VLBW infants with FIP. Knowledge on the development of the neonatal gut microbiota, local resistance patterns and individual microbiological findings should be taken into consideration when implementing antimicrobial stewardship programs (ASPs). (Source: Infection)
Source: Infection - April 18, 2024 Category: Infectious Diseases Source Type: research
Non-betahemolytic streptococcal bacteremia, cardiac implantable electronic device, endocarditis, extraction, and outcome; a population-based retrospective cohort study
ConclusionThe study did not find a high risk of IE in patients with NBHSB and CIED. Most cases of IE were in conjunction with a simultaneous HVP. A management algorithm is suggested. (Source: Infection)
Source: Infection - April 18, 2024 Category: Infectious Diseases Source Type: research
Noninvasive Prenatal Diagnosis of SEA-Thalassemia by Combining 1000 Genomes Database and Relative Haplotype Dosage
. (Source: Hemoglobin)
Source: Hemoglobin - April 18, 2024 Category: Hematology Authors: Dewen LiuXuejuan NongFengming LaiChen NongTaizhong WangYulian Tanga Graduate School, Youjiang Medical University for Nationalities, Baise, Guangxi, Chinab Center for Medical Laboratory Science, Affiliated Hospital of Youjiang Medical University for Nation Source Type: research
Editorial Comments: looking for some innovative diagnostic or developmental research studies that might influence our laboratory and clinical decision-making
For this issue, I have invited two leading experts to share the outcome of their innovative ongoing studies on the advancement of in vivo assessment of RBC and platelet function testing in specialized emergency cases. Prof. Jason Acker ’s team reports on two interrelated topics that are exceedingly relevant to modern Transfusion Medicine. The first manuscript is aimed at the influence of RBC quality in red cell concentrates on vascular redox homeostasis and associated redox signalling measures which are novel in vivo quality mea surements of red cell concentrates and reflect future directions in post-transfusion redox an...
Source: Transfusion and Apheresis Science - April 18, 2024 Category: Hematology Authors: Jerard Seghatchthiian Source Type: research
D-dimer and risk of venous thromboembolism recurrence: Comparison of two studies with similar designs but different laboratory and clinical results
D-dimer testing may help deciding the duration of anticoagulation in subjects at high risk of venous thromboembolism (VTE) recurrence. Two management studies on this issue have been published (DULCIS in 2014 and APIDULCIS in 2022). They had similar designs but had important different results. Aim of this article is to compare their results. (Source: Thrombosis Research)
Source: Thrombosis Research - April 18, 2024 Category: Hematology Authors: Gualtiero Palareti, Cristina Legnani, Alberto Tosetto, Daniela Poli, Sophie Testa, Walter Ageno, Vittorio Pengo, Benilde Cosmi, Paolo Prandoni Tags: Full Length Article Source Type: research
A multidisciplinary obesity registry for Iranian adults: a protocol
ConclusionThis registry aims to provide a comprehensive dataset on the epidemiology, outcomes and management process of obesity to serve as a foundation for later research projects and improve medical approaches toward this condition. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
The value of lipid accumulation products in predicting type 2 diabetes mellitus: a cross-sectional study on elderlies over 65 in Shanghai
ConclusionLAP is more significantly associated with the risk of T2DM in elderlies than FPG, UN or NC, and it serves as a strong predictor of T2DM. However, this is impacted by FPG and neck circumference to a certain extent. Future large-scale studies are needed to confirm its efficacy in predicting diabetes. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
(Non)-Exertional Variables of Cardiopulmonary Exercise Testing in Heart Failure with and Without Cardiac Amyloidosis
AbstractPurpose of ReviewCardiac amyloidosis (CA) constitutes an important etiology of heart failure with preserved ejection fraction (HFpEF) or heart failure with mildly reduced ejection fraction (HFmrEF). Since patients with CA show early exhaustion, we aimed to investigate whether non-exertional variables of cardiopulmonary exercise testing (CPET) provide additional information in comparison to traditional peak oxygen consumption (VO2peak).Recent FindingsWe retrospectively investigated CPET variables of patients with HFpEF and HFmrEF with (n = 21) and without (n = 21, HF) CA at comparable age and ejection fracti...
Source: Current Heart Failure Reports - April 18, 2024 Category: Cardiology Source Type: research
Sensors, Vol. 24, Pages 2587: Piezoelectric Sensors as Energy Harvesters for Ultra Low-Power IoT Applications
zebon
The aim of this paper is to discuss the usability of vibrations as energy sources, for the implementation of energy self-sufficient wireless sensing platforms within the Industrial Internet of Things (IIoT) framework. In this context, this paper proposes to equip vibrating assets like machinery with piezoelectric sensors, used to set up energy self-sufficient sensing platforms for hard-to-reach positions. Preliminary measurements as well as extended laboratory tests are proposed to understand the behavior of commercial piezoelectric sensors when employed as energy harvesters. First, a general architecture for a v...
Source: Sensors - April 18, 2024 Category: Biotechnology Authors: Francesco Rigo Marco Migliorini Alessandro Pozzebon Tags: Article Source Type: research
Sensors, Vol. 24, Pages 2588: A Laboratory Machine Verifying the Operation of a Hydraulic Rope Equalizer with Tensometric Sensors
This article presents a structural design, a 3D model and an implemented solution of a laboratory device capable of simulating a practical method of evenly distributing the total weight of the load into partial tensile forces of the same size acting on a selected number of load-bearing ropes. The laboratory equipment uses two pairs of three steel cables of finite length for the simulations. During the experimental measurements, tensile forces derived from the tractive force of the piston rods, pushed into the bodies of the hydraulic cylinders by the pressure of the hydraulic oil supplied through the pipeline under the pist...
Source: Sensors - April 18, 2024 Category: Biotechnology Authors: Leopold Hrabovsk ý Ji ří Fries Štěpán Pravda Tags: Article Source Type: research
Invited commentary on: sudden cardiac death
Postmortem examination holds a pivotal role in our society. The implications of this procedure are vast, ranging from medicolegal consequences to characterisation of heritable genetic syndromes and closure for those proximal to the deceased. Despite its widespread intrinsic value, a surprising 1%–5% of postmortem examinations will lack revealing gross, histologic, or laboratory findings that inform the cause of death.1 2 The so-called ‘negative autopsy’ is a challenge for the medical system and relatives of the deceased alike. A specific list of differential diagnoses is considered in the setting of a neg...
Source: Journal of Clinical Pathology - April 18, 2024 Category: Pathology Authors: Bois, M.D., M. C. Tags: Grand rounds commentary Source Type: research
From Castleman disease histopathological features to idiopathic multicentric Castleman disease: a multiparametric approach to exclude potential iMCD histopathological mimickers
Conclusions
HHV-8+ MCD and PCN/POEMS-related CD are the major mimickers of iMCD in lymph node biopsies. Grading of the five histopathological features for CD might be useful to, in conjunction with complete ancillary testing, suggest for specific disease entities. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - April 18, 2024 Category: Pathology Authors: Rodriguez Merino, L., Pomares, A. A., Arce, J. R., Montes-Moreno, S. Tags: Original research Source Type: research
