24-h passive heat and cold exposures did not modify energy intake and appetite but strongly modify food reward
Br J Nutr. 2024 Apr 18:1-40. doi: 10.1017/S0007114524000825. Online ahead of print.ABSTRACTEffects of acute thermal exposures on appetite appear hypothetical in reason of very heterogeneous methodologies. The aim of this study was therefore to clearly define the effects of passive 24-h cold (16°C) and heat (32°C) exposures on appetitive responses compared to a thermo neutral condition (24°C). Twenty-three healthy, young, and active male participants realised three sessions (from 1 pm) in a laboratory conceived like an apartment dressed with the same outfit (Clo=1). Three meals composed of three or four cold or warm dish...
Source: The British Journal of Nutrition - April 18, 2024 Category: Nutrition Authors: Maxime Coca Louis Besan çon M égane Erblang St éphanie Bourdon Arnaud Gruel Beno ît Lepetit Vincent Beauchamps Blandine Tavard Pauline Oustric Graham Finlayson David Thivel Alexandra Malgoyre Pierre-Emmanuel Tardo-Dino Cyprien Bourrilhon Keyne Charlot Source Type: research
Wide use of broad-spectrum antibiotics in very low birth weight infants with spontaneous focal intestinal perforation —is it really justified?
ConclusionThe use of carbapenems as broad-spectrum antimicrobials agents might not be justified in most VLBW infants with FIP. Knowledge on the development of the neonatal gut microbiota, local resistance patterns and individual microbiological findings should be taken into consideration when implementing antimicrobial stewardship programs (ASPs). (Source: Infection)
Source: Infection - April 18, 2024 Category: Infectious Diseases Source Type: research
Non-betahemolytic streptococcal bacteremia, cardiac implantable electronic device, endocarditis, extraction, and outcome; a population-based retrospective cohort study
ConclusionThe study did not find a high risk of IE in patients with NBHSB and CIED. Most cases of IE were in conjunction with a simultaneous HVP. A management algorithm is suggested. (Source: Infection)
Source: Infection - April 18, 2024 Category: Infectious Diseases Source Type: research
The predictive power of data: machine learning analysis for Covid-19 mortality based on personal, clinical, preclinical, and laboratory variables in a case –control study
The COVID-19 pandemic has presented unprecedented public health challenges worldwide. Understanding the factors contributing to COVID-19 mortality is critical for effective management and intervention strategi... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 18, 2024 Category: Infectious Diseases Authors: Maryam Seyedtabib, Roya Najafi-Vosough and Naser Kamyari Tags: Research Source Type: research
Implementation of a Three-Way Comparability Assessment for a Bioanalytical Anti-Drug Antibody Method
AbstractImmunogenicity evaluation is a critical part of drug development. Regulatory guidelines from multiple health agencies provide recommendations for the development and validation of anti-drug antibody (ADA) assays to assess immunogenicity in clinical trials. These recommendations primarily describe an ADA method run in one bioanalytical laboratory supporting a biotherapeutic molecule; however, there are increasing instances that may necessitate the support of the ADA method being run in more than one laboratory. A program can rapidly expand into multiple clinical studies within one or multiple countries, where the mo...
Source: The AAPS Journal - April 18, 2024 Category: Drugs & Pharmacology Source Type: research
Seasonal discrepancy of airborne fungal diversity and community structure in Lentinula edodes factory
. (Source: Mycology)
Source: Mycology - April 18, 2024 Category: Biology Authors: Wenbing GongKaixiao QiuZhen ZhuangLujun ZhangXueqing LiuXiao YuYinbing BianYang Xiaoa State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Institute of Applied Mycology, Huazhong Agricultural University, Wuhan, Chinab Institute of Source Type: research
Emergence of OXA-48-producing Klebsiella pneumoniae in Lithuania, 2023: a multi-cluster, multi-hospital outbreak
In 2023, an increase of OXA-48-producingKlebsiella pneumoniae was noticed by the Lithuanian National Public Health Surveillance Laboratory. Whole genome sequencing (WGS) of 106 OXA-48-producingK. pneumoniae isolates revealed three distinct clusters of carbapenemase-producingK. pneumoniae high-risk clones, including sequence type (ST) 45 (n = 35 isolates), ST392 (n = 32) and ST395 (n = 28), involving six, six and nine hospitals in different regions, respectively. These results enabled targeted investigation and control, and underscore the value of national WGS-based surveillance for antim...
Source: Eurosurveillance - April 18, 2024 Category: Infectious Diseases Authors: Paulius Grei čius, Marius Linkevicius, Jelena Razmuk, Jekaterina Sinotova, Erik Alm, Olov Svartström, Valeria Bortolaia, Eglė Kudirkienė, Louise Roer, Rene S Hendriksen, Gabija Tamoliūnaitė, Daniel Palm, Dominique L Monnet, Anke Kohlenberg and Algir Source Type: research
Thiostrepton suppresses triple-negative breast cancer through downregulating c-FLIP/SMAD2/3 signaling pathway
. (Source: Journal of Asian Natural Products Research)
Source: Journal of Asian Natural Products Research - April 18, 2024 Category: Complementary Medicine Authors: Wen-Die WangChao-Yang ZengYue ShangJun NiGao-Jie LiLi-Ping LiShuo-Han XiShu-Zhen Chena Department of Cancer Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing 100050, Chinab State Key Laboratory of Bioactive Subst Source Type: research
Effect and mechanism of gomisin D on the isoproterenol induced myocardial injury in H9C2 cells and mice
. (Source: Journal of Asian Natural Products Research)
Source: Journal of Asian Natural Products Research - April 18, 2024 Category: Complementary Medicine Authors: Zi-Han ChenYan-Xin LiuZhi-Wei ChenMo-Di LinJin-Lan ZhangZhe WangHua Suna State Key Laboratory of Digestive Health, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, Chinab Drug Analysis Research Laboratory, Institute of Mat Source Type: research
Distal renal tubular acidosis as a rare complication of vesicoureteral reflux in children: a case report and literature review
In conclusion, the development of hypokalemia and nephrolithiasis/nephrocalcinosis along with metabolic acidosis in a patient diagnosed with VUR should be considered as an indicator of impaired tubular functions. Also, the possibility of an underlying VUR in the p resence of recurrent urinary tract infection in a patient diagnosed with dRTA should not be ignored. (Source: CEN Case Reports)
Source: CEN Case Reports - April 18, 2024 Category: Urology & Nephrology Source Type: research
Aetiological molecular identification of sexually transmitted infections that cause urethral discharge syndrome and genital ulcer disease in Brazilian men: a nationwide study
Conclusion
This study provided the acquisition of unprecedented data on the aetiology of UDS and GUD in Brazil, demonstrated the presence of a variety of pathogens in both sample types and reaffirmed the aetiologies known to be most prevalent globally. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Bazzo, M. L., Machado, H. d. M., Martins, J. M., Schörner, M. A., Buss, K., Barazzetti, F. H., Gaspar, P. C., Bigolin, A., Benzaken, A., de Carvalho, S. V. F., Andrade, L. d. F., Ferreira, W. A., Figueiroa, F., Fontana, R. M., da Silva, M. F. d. C Tags: Original research Source Type: research
Can laboratory HIV and infectious syphilis data inform future pre-exposure prophylaxis use in women in Ontario, Canada?
Conclusion
Although it is clinically appropriate to recommend HIV PrEP to women with syphilis, Ontario surveillance data suggest that the population-level impact of this strategy on the HIV epidemic in Ontario would have been modest during this 11-year period. Future studies should explore additional ways of prioritising women for PrEP. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Sadeghi, Y., Nelson, P., Sullivan, A., Allen, V., Hasso, M., Liu, J., Tran, V., Tan, D. H. S. Tags: Open access Short reports Source Type: research
Phenotypic and Immunological Characterization of Patients with Activated PI3K δ Syndrome 1 Presenting with Autoimmunity
ConclusionsThe pathogenic immune phenotype of APDS1 patients included (1) deceased CD3+ T-cell and B-cell counts and increased IgG levels in patients with autoimmunity, (2) an imbalanced T helper cell subset, (3) increased proportions of autoreactive B cells, and (4) distinct autoantibody reactivities in patients with autoimmunity. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - April 18, 2024 Category: Allergy & Immunology Source Type: research
Wide use of broad-spectrum antibiotics in very low birth weight infants with spontaneous focal intestinal perforation —is it really justified?
ConclusionThe use of carbapenems as broad-spectrum antimicrobials agents might not be justified in most VLBW infants with FIP. Knowledge on the development of the neonatal gut microbiota, local resistance patterns and individual microbiological findings should be taken into consideration when implementing antimicrobial stewardship programs (ASPs). (Source: Infection)
Source: Infection - April 18, 2024 Category: Infectious Diseases Source Type: research
Non-betahemolytic streptococcal bacteremia, cardiac implantable electronic device, endocarditis, extraction, and outcome; a population-based retrospective cohort study
ConclusionThe study did not find a high risk of IE in patients with NBHSB and CIED. Most cases of IE were in conjunction with a simultaneous HVP. A management algorithm is suggested. (Source: Infection)
Source: Infection - April 18, 2024 Category: Infectious Diseases Source Type: research
