Antifungal and anti-biofilm effect of the calcium channel blocker verapamil on non-albicans Candida species.
In this study, we investigated the effect of verapamil on cell viability and its antifungal and anti-biofilm activity in non-albicans Candida species. Verapamil was not toxic to keratinocyte cells; moreover, C. krusei, C. parapsilosis, and C. glabrata were susceptible to verapamil with a minimal inhibitory concentration (MIC) of 1250 μM; in addition, this drug displayed fungistatic effect at the evaluated concentrations. After treatment with verapamil, reduced viability, biomass, and mitochondrial activity were observed in biofilms of the non-albicans Candida species C. krusei, C. glabrata, and C. parapsilosis. These fi...
Source: An Acad Bras Cienc - December 19, 2020 Category: Science Authors: Scorzoni L, Menezes RT, Pereira TC, Oliveira PS, Ribeiro FC, Santos ELS, Fugisaki LRO, Oliveira LD, Amorim JBO Tags: An Acad Bras Cienc Source Type: research

Floristic patterns of alluvial forests in Atlantic Forest and Pampa: Climate and geographic insertion as determining factors.
chi P Abstract The aims of this study were to identify floristic assemblages for alluvial forests in the Atlantic Forest and Pampa regions in Brazil, assess the level of floristic similarity between assemblages, and determine environmental gradients and indicator species for these assemblages. Surveys carried out in alluvial forests in the Atlantic Forest and Pampa regions were selected, based on which a presence/absence matrix was built for tree species. A cluster analysis was performed to verify the existence of species assemblages. Floristic similarity was determined by means of the Sorensen Distance measure, f...
Source: An Acad Bras Cienc - December 19, 2020 Category: Science Authors: Silva JO, GalvÃo F, Silva AC, Higuchi P Tags: An Acad Bras Cienc Source Type: research

Pollen morphology of family Solanaceae and its taxonomic significance.
In this study, thirteen species belonging to ten genera of Solanaceae have been studied using light and scanning electron microscopy for both qualitative and quantitative features. Solanaceae is a eurypalynous family and a significant variation was observed in pollen size, shape, polarity and exine sculpturing. Examined plant species includes, Brugmansia suaveolens, Capsicum annuum, Cestrum parqui, Datura innoxia, Solanum lycopersicum, Nicotiana plumbaginifolia, Petunia hybrida, Physalis minima, Solanum americanum, Solanum erianthum, Solanum melongena, Solanum surattense and Withania somnifera. The prominent pollen type is...
Source: An Acad Bras Cienc - December 19, 2020 Category: Science Authors: Ashfaq S, Ahmad M, Zafar M, Sultana S, Bahadur S, Ahmed SN, Gul S, Nazish M Tags: An Acad Bras Cienc Source Type: research

Microencapsulated carvacrol and cinnamaldehyde replace growth-promoting antibiotics: Effect on performance and meat quality in broiler chickens.
Abstract The aim was to evaluate the use of mixture of microencapsulated carvacrol and cinnamaldehyde as a replacement for growth-promoting antibiotics in broiler diets on performance, intestinal quality, organ development, carcass yields and cuts, and meat quality. In the trial were used 600 male chicks, allocated in a completely randomized design, with five treatments and eight replicates of 15 birds, reared up to 41 days of age. The treatments were: Negative Control (NC), Positive Control (PC) 30 mg/kg of virginiamycin, NC+100 mg/kg of essential oils, NC+200 mg/kg of essential oils and NC+400 mg/kg of essential...
Source: An Acad Bras Cienc - December 19, 2020 Category: Science Authors: Bosetti GE, Griebler L, Aniecevski E, Facchi CS, Baggio C, Rossatto G, Leite F, Valentini FDA, Santo AD, Pagnussatt H, Boiago MM, Petrolli TG Tags: An Acad Bras Cienc Source Type: research

Role of the endocannabinoid system on the antihyperalgesic action of gabapentin in animal model of neuropathic pain induced by partial sciatic nerve ligation.
This study aims to investigate the contribution of the endocannabinoid system to the antihyperalgesic action of gabapentin. Mus musculus Swiss, male, were submitted to PSL. On the 7th and 14th days post PSL, different groups were treated with CB1 receptor antagonist, AM281 via i.t. (2 μg/5 μl) or i.pl. (10 μg/20 μl) or CB2, AM630 via i.t. (5 μL i.t.) or (20 μL i.p.) and 15 min after gabapentin (30 mg / kg orally). Mechanical hyperalgesia was measured by the frequency of paw removal by the von Frey monofilament. Gabapentin demonstrated antihypernociceptive action, which was attenuated in animals pretreated...
Source: An Acad Bras Cienc - December 19, 2020 Category: Science Authors: Buffon AC, Javornik MA, Heymanns AC, Salm DC, Horewicz VV, Martins DF, Piovezan AP Tags: An Acad Bras Cienc Source Type: research

Gene Expression Profiling in Human Brain Microvascular Endothelial Cells in Response to Treponema pallidum Subspecies pallidum.
Abstract Neurosyphilis (NS) is a neurological disorder caused by Treponema pallidum subspecies pallidum (T. pallidum), but how T. pallidum attach to and cross the blood-brain barrier (BBB) and how BBB response to this bacteria remain unclear. To explore how the human brain microvascular endothelial cells (HBMECs) response to T. pallidum, the Agilent SurePrint G3 Human Gene Expression 8×60K microarray was used. The results revealed that 249 genes were differentially expressed in HBMECs infected with T. pallidum. In particular, genes encoding proteins involved in bacterial adhesion, endothelial cell activation...
Source: An Acad Bras Cienc - December 19, 2020 Category: Science Authors: Wu F, Shen K, Xie YI, Wang H, Sun Y, Wang Q Tags: An Acad Bras Cienc Source Type: research

Impact of different exercise intensities on pregnant rats and on their offspring.
In conclusion, the moderate-exercise intensity caused beneficial effects for maternal environment and the mild and moderate-exercise presented similar fetal repercussions. Nevertheless, the heavy-exercise intensity caused maternal metabolic alterations that damaged the fetal growth. Therefore, these findings confirm that physical intensity should be carefully conducted to avoid maternal complications and, consequently, compromised fetal repercussions. PMID: 33331442 [PubMed - indexed for MEDLINE] (Source: An Acad Bras Cienc)
Source: An Acad Bras Cienc - December 19, 2020 Category: Science Authors: Netto AO, Macedo NCD, Gallego FQ, Sinzato YK, Volpato GT, Zambrano E, Damasceno DC Tags: An Acad Bras Cienc Source Type: research

Resistance training prevents the reduction of insulin-mediated vasodilation in the mesenteric artery of dexamethasone-treated rats.
This study evaluated whether resistance training (RT) could prevent glucocorticoid-induced vascular changes. Wistar rats were divided into groups: control (CO), dexamethasone (DEX), and Dexamethasone+RT (DEX+RT). On the eighth week, dexamethasone was administered in the DEX and DEX+RT groups. Thereafter, the animals were sacrificed and blood samples were used to assess the lipid profile, glucose and insulin. Vascular reactivity to insulin and phenylephrine (Phe) were evaluated. The DEX+RT group presented an improvement in the lipid profile, fasting glucose, and insulin levels compared to the DEX group. In addition, vasodil...
Source: An Acad Bras Cienc - December 19, 2020 Category: Science Authors: Araujo JES, Macedo FN, Oliveira DPM, Britto RM, Quintans JSS, Barreto RSS, Santos MRV, Quintans-Junior LJ, Barreto AS Tags: An Acad Bras Cienc Source Type: research

Production of HPMC-films for lactase administration.
Abstract The present work aimed to develop and characterize HPMC-films (HFs) based on hydroxypropylmethylcellulose (HPMC) with the addition of lactase for later application in the reduction of lactose in whole milk. The HFs were produced by the casting technique, with the addition of 1, 3, 5 and 7 g of lactase per 100 g of filmogenic solution. All the formulations presented a high capacity of film formation, but the thickness and time of disintegration increased according to the added lactase concentration. Regardless of the formulation developed, HFs in whole milk, a reduction in the lactose content (~ 80%) occur...
Source: An Acad Bras Cienc - December 19, 2020 Category: Science Authors: Silva HRPD, Stevanato N, Garcia VAS, Silva CD Tags: An Acad Bras Cienc Source Type: research

Antimicrobial potential of Pectis substriata essential oil (Asteraceae) against drug-resistant Staphylococcus strains.
Abstract Resistant bacterial infections represent one of the major threats in worldwide health services. In this scenario, plant essential oils are considered promising antimicrobial agents. Therefore, this study aimed to evaluate the antimicrobial potential of Pectis substriata essential oil alone and in combination with antibiotics, against clinical drug-resistant bacterial strains. The essential oil from the plant aerial parts was obtained by hydrodistillation. Antimicrobial activity was assessed against standard and clinical bacterial strains by broth microdilution method, and the synergistic effect was evalua...
Source: An Acad Bras Cienc - December 19, 2020 Category: Science Authors: Jesus GS, Micheletti AC, Takahashi KM, Matayoshi T, Pott A, Yoshida NC Tags: An Acad Bras Cienc Source Type: research

Oral and uterine leiomyomas exhibit high immunoexpression of Cripto-1 compared to normal myometrium.
Abstract Leiomyomas are the most common benign tumors in women. Many of them are associated with significant morbidity. The present study aimed to analyze histomorphological and histochemical characteristics and immunoexpression of Cripto-1 in oral leiomyomas (OL), uterine leiomyomas (UL), and normal myometrium (NM). Sample was composed of ten OL, 11 UL and 11 NM. Histomorphological characteristics were analyzed at 100 and 400x magnifications with HE staining. The immunoexpression of Cripto-1 was analyzed in five high-power fields. Statistical analysis considered a significant difference when p
Source: An Acad Bras Cienc - December 19, 2020 Category: Science Authors: Silva AF, Silva ECCD, Oliveira CN, Rocha KBF, Miguel MCC, Pereira JS Tags: An Acad Bras Cienc Source Type: research

Antimicrobial potential of Copaiba Oil (Copaifera multijuga Hayne-Leguminosae) against bubaline mastitis multiresistant isolates.
Abstract Copaiba oil is a natural product used by Amazonian populations and recognized for its medicinal properties because it has significant antimicrobial activity for several pathogenic microorganisms. The present work aimed to evaluate and characterize the effect of natural oil produced by copaiba - Copaifera multijuga against multiresistant isolates of bubaline mastitis. The nitrocefin test was performed with isolates of Staphylococcus aureus from bubaline mastitis, which were 100% positive for beta-lactamase enzyme detection. Minimum Bactericidal Concentration (MBC) of 25% to 3.12% was obtained for Enterococ...
Source: An Acad Bras Cienc - December 19, 2020 Category: Science Authors: Oliveira DFF, Nascimento TP, Rodrigues CH, Batista JMS, Liu TPSL, Medeiros ES, Mota RA, Costa RMPB, Porto TS, Porto CS, Porto ALF Tags: An Acad Bras Cienc Source Type: research

Fasted condition in multicomponent training does not affect health parameters in physically active post-menopausal women.
DISCUSSION: The current research results, the first in the context of aging, agree with previous studies that analyzed chronic effects of fasting, showing that fasted exercise training did not improve anthropometric measurements, body composition, or blood markers compared to the fed condition after long-term exercise training. Together, these findings suggest that fasting during multicomponent training does not affect health parameters in physically active post-menopausal women. PMID: 33331448 [PubMed - indexed for MEDLINE] (Source: An Acad Bras Cienc)
Source: An Acad Bras Cienc - December 19, 2020 Category: Science Authors: Rodrigues JAL, Cunha THA, Ferezin LP, Bueno-JÚnior CR Tags: An Acad Bras Cienc Source Type: research

Physical exercise associated with vitamin D chronic supplementation reduces kidney injury induced by monosodium glutamate.
Abstract The aim was to evaluate the effects of chronic vitamin D (VD) supplementation associated with regular swimming over renal histomorphometric aspects in obese rats. Thirty Wistar male rats (5 days old) were used. Twenty four rats were given subcutaneous injections of monosodium glutamate (MSG; 4 g/kg), and six control rats were given an equimolar saline solution. At 21-days-old, the MSG-treated rats were randomly distributed among sedentary animals (S) and exercised (E, swimming; 3x/week). These groups were subdivided into groups orally supplemented with VD (12 μg/kg; 3x/week) or not supplemented (NS), t...
Source: An Acad Bras Cienc - December 19, 2020 Category: Science Authors: Zanuzo K, Guareschi ZM, Detogni AC, Huning LP, Rodrigues PF, Porto EM, Grassiolli S, Amorim JPA Tags: An Acad Bras Cienc Source Type: research

Ecology, interactions and human perceptions of Cerdocyon thous in rural landscapes in the state of Pernambuco, Brazil.
Abstract Human populations maintain diverse relationships with wild animals that lead to both positive and negative interactions. The aim of the present study was to investigate the ecology, interactions and human perceptions of Cerdocyon thous in rural landscapes in the state of Pernambuco in northeastern Brazil. Interviews were held from November to December 2015. Data collection involved the use of a semi-structured questionnaire and photographs of the fox. Most interviewees (96.94%) demonstrated knowledge of the species, attributing eight different vernacular denominations to the animal. The interviewees also ...
Source: An Acad Bras Cienc - December 11, 2020 Category: Science Authors: Silva LTD, Souza ACFF, Silva LAMD Tags: An Acad Bras Cienc Source Type: research

Information items to improve Integration Readiness Levels evaluation.
This article contributes to the research in integration readiness assessments, aims to support professionals who carry out evidence-based evaluations and, consequently, may contribute to improving the accuracy of decision-making in the systems integration by using this scale. PMID: 33295483 [PubMed - in process] (Source: An Acad Bras Cienc)
Source: An Acad Bras Cienc - December 11, 2020 Category: Science Authors: Jesus GT, Chagas Junior MF Tags: An Acad Bras Cienc Source Type: research

Isolation and identification of Saccharomyces cerevisiae for fermentation of rice polishing in Livestock feeding.
Abstract Biomass of Saccharomyces cerevisiae wasenhancedin rice polishing by fermentation to increase protein contents of feedfor its use in livestock. Broth culture of Saccharomyces cerevisiae (2.6×108CFU/mL) was prepared from culture obtained by continuous streaking. The isolated culture was identified morphologically by Gram staining and confirmed by biochemical characteristics. Rice polishing was sieved to remove larger particles. Then it was distributed to 4 treatments in triplicates. Treatments were represented as rice polishing (RP), rice polishing plus Saccharomyces culture (RPSC), rice polishing plu...
Source: An Acad Bras Cienc - December 11, 2020 Category: Science Authors: Sharif M, Zafar MH, Rahman SU, Anam S, Ashfaq K, Aqib AI Tags: An Acad Bras Cienc Source Type: research

Assessing raw materials as potential adsorbents to remove acidic compounds from Brazilian crude oils by ESI (-) FT-ICR MS.
Abstract The presence of acidic compounds as naphthenic acids in crude oil causes several problems for the petroleum industry, including corrosion in both upstream and downstream production processes. Based on this scenario, the main objective of this work was to investigate the removal of the acidic compound from two Brazilian heavy oils by adsorption processes using six potential adsorbents: powdered shale, activated carbon, bentonite, silica gel, powdered sandstone and powdered wood. These raw materials were previously characterized by conventional and surface analysis techniques, which show that they offer a g...
Source: An Acad Bras Cienc - December 11, 2020 Category: Science Authors: Abib GAP, Martins LL, Araujo LLGC, Isidorio TV, Pudenzi MA, Santos VH, Cruz GFD Tags: An Acad Bras Cienc Source Type: research

Ammonia exposition during gestation induces neonatal oxidative damage in the brain and long-term cognitive alteration in rats.
zol F Abstract Ammonia is involved in the pathogenesis of neurological conditions associated with hyperammonemia, including hepatic encephalopathy. Few is known about the effects of gestational exposition to ammonia in the developing brain, and the possible long-term consequences of such exposure. We aimed to evaluate the effects of ammonia exposure during the gestation and the possible long-term cognitive alterations on pups. Eight female rats were divided into two groups: (1) control (saline solution); (2) ammonia (ammonium acetate, 2,5mmol/Kg). Each rat received a single subcutaneous injection during all gestat...
Source: An Acad Bras Cienc - December 11, 2020 Category: Science Authors: Dominguini D, Dall'igna DM, Nogueira L, Steckert AV, GonÇalves RC, Michels M, Quevedo J, Ritter C, Barichello T, Dal-Pizzol F Tags: An Acad Bras Cienc Source Type: research

Does Sciaena umbra (Linnaeus 1758) otolith protect tissues against nephropathy, oxidative stress and inflammation induced by ethylene glycol?
Abstract Sciaena umbra is a species of fish with large otoliths. These otoliths are used for treatment of kidney stone disease with high morbidity among the public. In present study, the first group was determined as a control. Group 2 was applied to rats by adding 1% ethylene glycol to drinking water. Group 3 rats were given 50 mg/kg otolith by gavage daily. Group 4 rats were administered by adding ethylene glycol and otolith was given. Group 5 rats were added ethylene glycol for the first 30 days. Then next 15 days, the rats were given only otolith. the Serum CREA and BUN levels and urine calcium, phosphate and ...
Source: An Acad Bras Cienc - December 11, 2020 Category: Science Authors: Aksoy L, Yaylali M, Suyundikov M Tags: An Acad Bras Cienc Source Type: research

Antioxidant activitiy of Lactobacillus plantarum , Lactobacillus sake and Lactobacillus curvatus strains isolated from fermented Turkish Sucuk.
İ Abstract In recent years, it is very important to find more safe and natural antioxidants than biological sources to replace synthetic antioxidants. The antioxidant properties of 22 lactic acid bacteria were investigated in vitro in the present study. The conducted in vitro antioxidant assays included scavenging the 2,2-diphenyl-1-picrylhydrazil (DPPH) free radical, metal (Fe+2) ion chelation, hydroxyl radical and superoxide radical scavenging properties, and anti-lipid peroxidation. Analysis of DPPH free radical scavenging property of microorganisms demonstrated that Lactobacillus plantarum IH14L (90.34 &plus...
Source: An Acad Bras Cienc - December 11, 2020 Category: Science Authors: DÜz M, DoĞan YN, DoĞan İ Tags: An Acad Bras Cienc Source Type: research

Prevalence of Illicit Drug Use During Pregnancy: A Global Perspective.
This study reveals worrying data about pregnant drug-user population, mainly the underestimation of prevalence in studies that use only questionnaires or similar methods in comparison to studies that use toxicological analysis of biological matrices. This scenario reveals necessity for health systems in different countries to establish specific public health policies for this population. PMID: 33295578 [PubMed - in process] (Source: An Acad Bras Cienc)
Source: An Acad Bras Cienc - December 11, 2020 Category: Science Authors: Tavella RA, DE Abreu VOM, Muccillo-Baisch AL, DA Silva JÚnior FMR Tags: An Acad Bras Cienc Source Type: research

FAS gene polymorphisms (rs3740286 and rs4064) were not associated with pre-eclampsia risk.
ti CW Abstract Pre-eclampsia results in real risk and significant impact on indicators related to maternal and child health. The only known treatment is delivery of the fetus and placenta. Despite intensive research, the causes of PE remain to be elucidated. It is suggested that pre-eclampsia is caused by a global maternal inflammatory response to a damaged placenta. Besides inflammation, cytotoxic and apoptotic mechanisms are also implicated in the pathogenesis of pre-eclampsia. Considering the importance of apoptosis to pre-eclampsia genesis, the aim of this study was to determine the frequencies of the genotype...
Source: An Acad Bras Cienc - December 11, 2020 Category: Science Authors: Tanaka SCSV, Orlando JÚnior IC, Hortolani ACC, Cintra MTR, Balarin MAS, Silva SRD, Pissetti CW Tags: An Acad Bras Cienc Source Type: research

Evaluation of hematology, general serum biochemistry, bone turnover markers and bone marrow cytology in a glucocorticoid treated ovariectomized sheep model for osteoporosis research.
as IR Abstract Osteoporosis is a metabolic disorder characterized by a loss of bone mass and structure and increasing the risk of fragility fractures, mostly among postmenopausal women. Sheep is a recognized large animal model for osteoporosis research. An experimental group of ewes (3-4 years old) was subjected to ovariectomy (OVX) and weekly glucocorticoid (GC) application for 24 weeks and compared with a sham control group. Blood and bone marrow parameters were analyzed before and 24 weeks after OVX and GC administration. Osteopenia was confirmed through micro-computed tomography and histomorphometric analysis ...
Source: An Acad Bras Cienc - December 11, 2020 Category: Science Authors: Coelho CA, Bordelo JP, Camassa JA, Barros VA, Babo PS, Gomes ME, Reis RL, Azevedo JT, Requicha JF, FaÍsca P, Carvalho PP, Viegas CA, Dias IR Tags: An Acad Bras Cienc Source Type: research

Impact of prenatal lipopolysaccharide exposure on the development of rats.
In this study, the aim was to investigate the impact of prenatal lipopolysaccharide exposure on the development of rats. Fifty pregnant rats received intraperitoneal administration of lipopolysaccharide (100 µg/kg), or saline at the same dose, on the 9.5th day of pregnancy. The offspring of these rats were analyzed for indicators of brain and somatic development and maturation of physical characteristics. Refl ex ontogenesis was also analyzed by vibrissae placement, negative geotaxis, palmar grasp, precipice aversion, decubitus recovery and acceleration reaction. Administration of lipopolysaccharide on the 9.5th gest...
Source: An Acad Bras Cienc - December 11, 2020 Category: Science Authors: Silva MG, Daros GC, Santos GM, Angelino IP, Bitencourt RM, Fortunato JJ Tags: An Acad Bras Cienc Source Type: research

Protease from Mucor subtilissimus UCP 1262: Evaluation of several specific protease activities and purification of a fibrinolytic enzyme.
Abstract The industrial demand for proteolytic enzymes is stimulating the search for new enzyme sources. Fungal enzymes are preferred over bacterial enzymes, and more effective and easier to extract. The aim of this work was to evaluate the potential of protease production by solid state fermentation (SSF) of Mucor subtilissimus UCP 1262, evaluate different specific activities, purify and partially characterize the enzyme in terms of biochemical as to the optimal pH and temperature. Initially, the enzyme crude extract was screened for 3 different proteolytic activities, collagenolytic (161.4 U/mL), keratinolytic (...
Source: An Acad Bras Cienc - December 11, 2020 Category: Science Authors: Nascimento TP, Conniff AES, Moura JAS, Batista JMS, Costa RMPB, Porto CS, Takaki GMC, Porto TS, Porto ALF Tags: An Acad Bras Cienc Source Type: research

Anti-Leishmania amazonensis activity of the terpenoid fraction from Eugenia pruniformis leaves.
This study aimed to evaluate the anti-Leishmania amazonensis activity of the terpenoid fraction of Eugenia pruniformis leaves (TF-EpL). TF-EpL was active against the promastigote and intracellular amastigote forms of L. amazonensis with IC50(24h) value of 43.60μg/mL and 44.77μg/mL, respectively. TF-EpL altered the cell cycle of the parasite, increasing 2.32-fold the cells in the Sub-G0/G1 phase. TF-EpL also changed the ΔΨm and increased ROS and the number of annexin-V-PI positive promastigotes, which suggests incidental death. β-sitosterol, ursolic acid, corosolic acid and asiatic acid were isolated fr...
Source: An Acad Bras Cienc - December 11, 2020 Category: Science Authors: Albuquerque RDDG, Oliveira AP, Ferreira C, Passos CLA, Fialho E, Soares DC, Amaral VF, Bezerra GB, Esteves RS, Santos MG, Albert ALM, Rocha L Tags: An Acad Bras Cienc Source Type: research

A glance upon Epigenetic and COVID-19.
e;o F Abstract Epigenetics studies focused on SARS-CoV-2 infection to assist in the perception of pathophysiology can direct prospective approaches for the COVID-19 treatment. There is an intrinsic relationship between epigenetic marks and the adaptation of the immune system, which determines the outcome of the pathogen-host interaction. Recently, studies have shown that there is an increased expression of the ACE2 receptor in individuals with Lupus, the origin of this phenomenon is from DNA's methylation deregulation process that consequently, become this group more suitable to be infected by SARS-CoV-2. There is...
Source: An Acad Bras Cienc - December 11, 2020 Category: Science Authors: Freitas NL, Azevedo PRG, BrandÃo F Tags: An Acad Bras Cienc Source Type: research

Not everything is condemned by COVID-19.
Atilde;es A Abstract The increase in the number of studies related to the health of university students has attracted attention at the time of COVID-19. This initiative contributes to preparing the school environment for the return of face-to-face activities with conducts that minimize the damage caused by the pandemic. The role of each actor in the educational scenario is fundamental for us to be able to reap good fruits after this storm. PMID: 33295585 [PubMed - in process] (Source: An Acad Bras Cienc)
Source: An Acad Bras Cienc - December 11, 2020 Category: Science Authors: JÚnior WP, Neto FFL, Grabe-GuimarÃes A Tags: An Acad Bras Cienc Source Type: research

A brief summary of the impact and performance of different scientific fields at the AABC.
PMID: 33295586 [PubMed - in process] (Source: An Acad Bras Cienc)
Source: An Acad Bras Cienc - December 7, 2020 Category: Science Authors: Kellner AWA Tags: An Acad Bras Cienc Source Type: research

Partial inclusion of bis(1,10-phenanthroline)silver(I) salicylate in β-cyclodextrin: Spectroscopic characterization, in vitro and in silico antimicrobial evaluation.
Partial inclusion of bis(1,10-phenanthroline)silver(I) salicylate in β-cyclodextrin: Spectroscopic characterization, in vitro and in silico antimicrobial evaluation. An Acad Bras Cienc. 2020;92(3):e20181323 Authors: BriÑez-Ortega E, Almeida VL, Lopes JCD, Burgos AE Abstract Silver complexes containing 1,10-phenanthroline as a coordinated ligand have been of great interest due to their antibacterial and antifungal pharmacological properties. In this paper, we describe the synthesis of a new partial inclusion complex of bis(1,10-phenanthroline)silver(I) salicylate in β-cyclodextrin (&be...
Source: An Acad Bras Cienc - December 3, 2020 Category: Science Authors: BriÑez-Ortega E, Almeida VL, Lopes JCD, Burgos AE Tags: An Acad Bras Cienc Source Type: research

Volatile Compounds of Different Fresh Wet Noodle Cultivars Evaluated by Headspace Solid-Phase Microextraction-Gas Chromatography-Mass Spectrometry.
This study was carried out to determine the volatile compounds from four samples of fresh wet noodles and the changes in the volatile compound composition during the storage process. The volatile compounds from four samples of fresh wet noodles were characterized by headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME/GC-MS). The compositions of the volatile compounds varied among fresh and cooked wet noodles made from the raw potato/wheat flour or wheat flour. A total of 194 volatile compounds were detected in the raw potato noodles, main volatiles including aldehydes, ...
Source: An Acad Bras Cienc - December 3, 2020 Category: Science Authors: Wu Y, Liang S, Zheng Y, Zhang M Tags: An Acad Bras Cienc Source Type: research

Genetic structure and diversity of native Guadua species (Poaceae: Bambusoideae) in natural populations of the Brazilian Amazon rainforest.
This study aimed to evaluate the genetic diversity and structure of two native Guadua species in natural populations in the Southwestern region of the Brazilian Amazon. Therefore, the genetic diversity and structure of Guadua aff. chaparensis and Guadua aff. lynnclarkiae were evaluated with the use of microsatellite molecular markers (SSR). It was verified that the average genetic diversity for the populations studied was considered high ( H ^ e =0.5) compared to other species of bamboo. All populations had rare and private alleles, and none of them presented significant values of inbreeding. The populations were divergent...
Source: An Acad Bras Cienc - December 3, 2020 Category: Science Authors: Silva SMM, Martins K, Costa FHS, Campos T, Scherwinski-Pereira JE Tags: An Acad Bras Cienc Source Type: research

Assessment of SNP-SNP interactions by using square contingency table analysis.
In this study, symmetry models for square contingency tables are applied to the cross-classified SNP-SNP interactions data. Results from a genome-wide association analysis of blood pressure are used as a prior evidence for the interacted SNPs. PMID: 33263659 [PubMed - as supplied by publisher] (Source: An Acad Bras Cienc)
Source: An Acad Bras Cienc - December 3, 2020 Category: Science Authors: KaradaĞ Ö, Altun G, AktaŞ S Tags: An Acad Bras Cienc Source Type: research

Characterization, fractionation and mobility of trace elements in surface sediments of the Jequiezinho River, Bahia, Brazil.
This study evaluated the geochemical distribution and potential mobility of some metals (Pb, Co, Ca, Cr, Mg, Cu, Fe, Mn, Ni and Zn) in sediments of the Jequiezinho River. Sediment samples were collected at ten different sites along the river. The silt/clay fraction was submitted to acid digestion and sequential extraction with analysis by FAAS. The results indicated that, in the more densely populated region, there was an increase in concentrations of Cr, Ni, Cu, Co, Pb, and Zn. The contents found were compared with the guideline values of TEL (Threshold Effect Levels) and PEL (Probable Effect Levels)​​, not exceeding ...
Source: An Acad Bras Cienc - December 3, 2020 Category: Science Authors: Silva DS, Cerqueira UMFM, Aguiar RM, Carneiro PLS, Bezerra MA Tags: An Acad Bras Cienc Source Type: research

Comparison of modified alpha functions of the PR-EoS for volume and enthalpy prediction of natural gases.
r EFD Abstract Proper simulation of processes of the natural gas industry such as dehydration, liquefaction and regasification require accurate prediction of thermodynamic properties of the working fluids. For such processes, cubic equations of state are the calculation methods most frequently employed. Among them, the Peng-Robinson equation is usually the one recommended for gas, refinery and petrochemical applications in many simulators. Numerous works have been proposed in order to improve the temperature dependence relation of the attraction parameter of the equation - the so called alpha function. In this wor...
Source: An Acad Bras Cienc - December 3, 2020 Category: Science Authors: GonÇalves AF, Costa AOSD, Costa Junior EFD Tags: An Acad Bras Cienc Source Type: research

Influence of depth on bryozoan richness and distribution from the continental shelf of the northern coast of Bahia State, north-eastern Brazil.
Abstract Biological and abiotic processes influence ecosystem structure and species distribution. For bryozoan assemblages, depth, substratum and habitat structure are among the main factors influencing their distribution. Ecological studies on bryozoan fauna from Brazil are scarce and factors affecting the distribution and/or diversity of this common group are obscure. Here we attempted to verify the influence of bathymetry on bryozoan richness on the north shore of Bahia State, north-eastern Brazil. We identified 57 bryozoan taxa, comprising 35 families and 50 genera, all belonging to the Cheilostomata. Retevirg...
Source: An Acad Bras Cienc - December 3, 2020 Category: Science Authors: Almeida ACS, Souza FBC, Vieira LM, Nogueira MM Tags: An Acad Bras Cienc Source Type: research

Anti-inflammatory and Anti-endoplasmic reticulum stress Effects of catalpol Against myocardial ischemia-reperfusion injury in streptozotocin-induced diabetic rats.
In conclusion, catalpol exerts cardioprotective effects in diabetic rats by attenuating inflammation and inhibiting ERS. PMID: 33237136 [PubMed - as supplied by publisher] (Source: An Acad Bras Cienc)
Source: An Acad Bras Cienc - November 26, 2020 Category: Science Authors: Bi F, Xu Y, Chen G, Wang P Tags: An Acad Bras Cienc Source Type: research

Taurine Chloramine decreases cell viability and cytokine production in blood and spleen lymphocytes from septic rats.
Abstract Taurine (Tau) is an abundant amino acid in polymorphonuclear leukocytes that react with hypochlorous acid to form taurine chloramine (TauCl) under inflammatory conditions. We investigated potential interactions between lymphocytes and TauCl in rats submitted to cecal ligation. Animals were divided into sham or CLP groups (24 or 120 h) to isolate lymphocytes from blood and spleen. Lymphocytes were cultured at a concentration of 1×106 cells/mL and activated by concanavalin A. Tau and TauCl were added at 1, 10, and 100 μM. Cells were incubated with MTT to evaluate cell viability and cytokine concent...
Source: An Acad Bras Cienc - November 26, 2020 Category: Science Authors: Dall'igna DM, Luz JMD, Vuolo F, Michels M, Dal-Pizzol F Tags: An Acad Bras Cienc Source Type: research

Leaf extracts of Campomanesia xanthocarpa positively regulates atherosclerotic-related protein expression.
Abstract Atherosclerosis is caused by a monocyte-mediated inflammatory process that, in turn, is stimulated by cytokines and adhesion molecules. Monocytes are then differentiated into macrophages, leading to the formation of arterial atherosclerotic plaques. Recently, guavirova leaf extracts from Campomanesia xanthocarpa (EG) have shown potential effects on the treatment of plaque formation by reducing cholesterol, LDL levels and serum oxidative stress. We evaluated the effect of EG on the viability of human monocytic and endothelial cell lines at three time points (24, 48 and 72 hours) and whether it can modulate...
Source: An Acad Bras Cienc - November 26, 2020 Category: Science Authors: Cunha EBB, Silva NFD, Lima J, Serrato JA, Aita CAM, Herai RH Tags: An Acad Bras Cienc Source Type: research

Seseli petraeum M. Bieb. (Apiaceae) Significantly Inhibited Cellular Growth of A549 Lung Cancer Cells through G0/G1 Cell Cycle Arrest.
Abstract Seseli L. is an important genus of the Apiaceae family, with a large number of aromatic species. It is used in traditional medicine extensively, but there is quite limited information on their phytochemicals and biological activities. Seseli petraeum M. Bieb. grows in Northern Anatolia, and there are no phytochemical studies on this species. In the present study, we aimed to investigate the effect of the extracts of S. petraeum on A549 lung cancer cell proliferation. For this purpose, the antiproliferative effect was determined via MTT assay, and the extracts obtained from the root of S. petraeum showed a...
Source: An Acad Bras Cienc - November 26, 2020 Category: Science Authors: Cinar AS, Bakar-Ates F, Onder A Tags: An Acad Bras Cienc Source Type: research

Effects of grape juice consumption on muscle fatigue and oxidative stress in judo athletes: a randomized clinical trial.
CD Abstract Physiological levels of reactive oxygen species (ROS) are important for intracellular and extracellular redox regulation in signaling and defense processes. Strenuous exercise can also contribute to this imbalance, and the muscle fatigue, evidenced by impaired strength or power generation, can be caused by various reasons, including oxidative stress. Antioxidants can prevent the formation of ROS by intercepting free radicals. Twenty judo athletes were included in this randomized, double-blind clinical trial into grape juice and placebo groups, and they consumed grape juice or placebo daily for 14 days...
Source: An Acad Bras Cienc - November 26, 2020 Category: Science Authors: Goulart MJVC, Pisamiglio DS, MÖller GB, Dani C, Alves FD, Bock PM, Schneider CD Tags: An Acad Bras Cienc Source Type: research

Development of nanoparticles coated with cassava bagasse pectin (Manihot esculenta Crantz) containing β-carotene for mucoadhesive applications.
Development of nanoparticles coated with cassava bagasse pectin (Manihot esculenta Crantz) containing β-carotene for mucoadhesive applications. An Acad Bras Cienc. 2020;92(4):e20200134 Authors: Coelho B, Mazzarino L, Pitz HS, Feltrin C, Voytena APL, Coelho DS, Schneider NFZ, Neubert EO, SimÕes CMO, Maraschin M Abstract Pectin (PC) extracted from a solid residue from cassava roots (Manihot esculenta Crantz) was used to coat nanoparticles (NP) containing β-carotene (BC) aiming at the gastrointestinal administration of this lipophilic nutraceutical. The NP were prepared by spontaneous em...
Source: An Acad Bras Cienc - November 26, 2020 Category: Science Authors: Coelho B, Mazzarino L, Pitz HS, Feltrin C, Voytena APL, Coelho DS, Schneider NFZ, Neubert EO, SimÕes CMO, Maraschin M Tags: An Acad Bras Cienc Source Type: research

Effects of the inclusion of a çai oil in diet of prepartum Holstein cows on milk production, somatic cell counts and future lactation.
Effects of the inclusion of açai oil in diet of prepartum Holstein cows on milk production, somatic cell counts and future lactation. An Acad Bras Cienc. 2020;92(4):e20200149 Authors: Santos DSD, Klauck V, Souza CF, Baldissera MD, Theisen C, Bordignon B, Alba DF, Reis JH, Gebert RR, Vedovatto M, Silva ASD Abstract We measured the effects of açai oil in the diets of prepartum cows to evaluate health, milk production and quality. Sixteen Holstein cows were divided into two groups: SOY used as control, and AÇAI, test group. Occurred inclusion of 4% soybean or açai oils was pro...
Source: An Acad Bras Cienc - November 26, 2020 Category: Science Authors: Santos DSD, Klauck V, Souza CF, Baldissera MD, Theisen C, Bordignon B, Alba DF, Reis JH, Gebert RR, Vedovatto M, Silva ASD Tags: An Acad Bras Cienc Source Type: research

Anti-inflammatory effects of vinpocetine in LPS-stimulated microglia via activation of AMPK.
Abstract Microglia are the resident immune cells in the central nervous system (CNS), which play important roles in the repair of neuroinflammatory injury. The present study investigated the anti-neuroinflammatory effects of vinpocetine induced by lipopolysaccharide (LPS) in BV2 microglia. BV2 microglia were pretreated with vinpocetine, and then stimulated with LPS (100 ng/mL). The cytotoxicity of BV2 microglia was assessed by MTT assay. The expression levels of nitrite oxide were measured by Griess assay. Proinflammatory cytokines and mediators were determined by Western blot, ELISA, or quantitative real-time PCR...
Source: An Acad Bras Cienc - November 26, 2020 Category: Science Authors: Zhou Q, Guo D, Li X, Wang Y, Ye X, Xue S, Wang X Tags: An Acad Bras Cienc Source Type: research

Relationship between the hsa miR 150-5p and FTO gene expression in white subcutaneous adipose tissue with overweight/obesity, lipid profile and glycemia.
no CR Abstract The overweight population is growing in the world, and the search for obesity-associated mechanisms is important for a better understanding of this disease. Few studies with the FTO gene and miRs show how they associate to obesity and how they can impact this disease. The aim of this study was to verify the relationship between the FTO gene and the hsa-miR-150-5p expression with overweight/obesity, lipid profile, and fast blood glucose. Men and women (18 years older or above), with body mass index ≥ 18.5 kg/m2, were enrolled in the present study and the FTO gene and hsa-miR-150-5p expression, bio...
Source: An Acad Bras Cienc - November 26, 2020 Category: Science Authors: Moraes VN, Queiroz AL, Martone D, Rodrigues JAL, Gomes MM, Salgado JÚnior W, Bueno CR Tags: An Acad Bras Cienc Source Type: research

Clinico-epidemiological and sociodemographic profile of HIV/AIDS patients who are co-infected with Toxoplasma gondii in the border region of Brazil.
Abstract The present study assessed clinico-epidemiological and sociodemographic characteristics and risk factors for human immunodeficiency virus (HIV) in patients who were co-infected with T. gondii in the border region of Brazil. HIV-positive patients who were attended by the Expert Assistance Service in Foz do Iguaçu city were assessed using a questionnaire and medical records. Of the 332 patients with HIV/autoimmune deficiency syndrome (AIDS) who were evaluated, 111 had serology for toxoplasmosis, which could be attributed to the location of the city (i.e., border region) and tourism that encourages th...
Source: An Acad Bras Cienc - November 26, 2020 Category: Science Authors: Moro JC, Moreira NM Tags: An Acad Bras Cienc Source Type: research

Schinopsis brasiliensis Engl. to combat the biofilm-dependents diseases in vitro.
This study aimed to evaluate the antimicrobial activity and cytotoxicity of extracts made from the bark of Schinopsis brasiliensis Engl. against five oral microorganisms and analyze their phytochemical and thermal degradation profile. The liquid-liquid partition was performed with hexane, chloroform and ethyl acetate. The identification and quantification of the chemical marker was done. Antimicrobial activity was evaluated based on the minimum inhibitory concentration. The cytotoxicity was analyzed based on the hemolysing potential of the samples. The thermal degradation profile was performed by two different methods. Gal...
Source: An Acad Bras Cienc - November 26, 2020 Category: Science Authors: Sette-DE-Souza PH, Santana CP, Sousa IMO, Foglio MA, Medeiros FD, Medeiros ACD Tags: An Acad Bras Cienc Source Type: research

Potentiation of the Effect of Lonidamine by Quercetin in MCF-7 human breast cancer cells through downregulation of MMP-2/9 mRNA Expression.
Abstract Combination therapies are becoming increasingly important to develop an effective treatment in cancer. Lonidamine is frequently used in cancer treatment, but it's often preferred to be used in combination with other drugs because of its side effects. In the present study, the efficacy of the combination of lonidamine with quercetin, a flavonoid of natural origin, on human MCF-7 breast cancer cells was evaluated. The results showed that the combined use of the compounds significantly increased cytotoxicity compared to administration alone (p
Source: An Acad Bras Cienc - November 26, 2020 Category: Science Authors: Ozkan E, Bakar-Ates F Tags: An Acad Bras Cienc Source Type: research

Chitosan gels for buccal delivery of Schinus molle L. essential oil in dogs: characterization and antimicrobial activity in vitro.
In this study, we evaluated the in vitro antimicrobial activity of SMEO against bacteria associated with periodontal disease in dogs, developed and evaluated the physicochemical properties of a novel chitosan-based buccal delivery system containing SMEO. SMEO showed antimicrobial activity against Gram positive and Gram negative bacteria associated with canine periodontitis, with MIC values of 750 µg.mL-1 for Staphylococcus spp. and Streptococcus spp, 1000 µg.mL-1 for Corynebacterium spp. and 1250 µg.mL-1 for Pseudomonas spp. All formulations evaluated presented adequate physicochemical properties, good st...
Source: An Acad Bras Cienc - November 26, 2020 Category: Science Authors: Alves MCC, Chaves DSA, Benevenuto BR, Farias BO, Coelho SMO, Ferreira TP, Pereira GA, Santos GCMD, Moreira LO, Freitas JP, Cid YP Tags: An Acad Bras Cienc Source Type: research