CCR Grand Rounds: Glypicans as Cancer Targets for CAR-T Immunotherapy
CCR Grand Rounds “ Glypicans as Cancer Targets for CAR-T Immunotherapy ” Mitchell Ho, Ph.D.Senior Investigator& Deputy ChiefLaboratory of Molecular BiologyCenter for Cancer Research, NCIFriday, April 19, 202412:00 – 1:00 p.m.Lipsett AmphitheaterAlso available to view via NIH Videocast.Dr. Mitchell Ho is a Senior Investigator and Deputy Chief of the Laboratory of Molecular Biology and Director of the Antibody Engineering Program at the Center for Cancer Research, NCI. Dr. Ho's research encompasses investigating molecular mechanisms by which glypicans such as GPC1, GPC2 and GPC3 regulate Wnt signaling, as well as d...
Source: Videocast - All Events - April 15, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar Series: Harnessing Mechanistic Insights into microRNA Function for Cancer Therapy
As a class of small non-coding RNAs, microRNAs (miRNAs) function as master gene regulators. My laboratory studies how miRNAs themselves are regulated and their applications in cancer treatment. Despite the success of using miRNAs including their isoforms (isomiRs) as disease biomarkers, development of miRNA-based cancer treatments was somewhat lagging behind mainly due to the difficulty in identifying tumor-driver miRNA variations. In this talk, I will discuss our endeavor in addressing this challenge by investigating the mechanisms of miRNA biogenesis and function. I will demonstrate how the addition of sequences at their...
Source: Videocast - All Events - April 1, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH FDA COVID-19 SIG: Metabolic causes and consequences of post-viral syndromes
Maayan Levy, PhD, is an Assistant Professor of Microbiology at the Perelman School of Medicine, University of Pennsylvania. Her research investigates the fascinating question of how metabolites derived from diet and from the microbiome play a pivotal role in regulating various aspects of host physiology. Moreover, she explores the potential therapeutic applications of these metabolites. Maayan completed her doctoral training at the Weizmann Institute of Science. During her PhD studies, she focused on crucial questions concerning the stability of the intestinal microbiome and made significant discoveries related to microbio...
Source: Videocast - All Events - March 27, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Neuropsychiatric lupus: a nonresolving inflammation
Following a serendipitous finding that some anti-DNA antibodies cross react with the NMDA receptor on neurons, the Diamond laboratory developed a model of cognitive impairment in SLE that has many features in common with the cognitive impairment experienced by patients with neuropsychiatric lupus. A major feature is microglial activation and dendritic pruning of neurons. As patients report cognitive impairment to be one of three symptoms that most interfere with quality of life, an understanding of pathogenesis is critical.Air date: 4/10/2024 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 21, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Neuronal Control of Cutaneous Inflammation
Daniel H. Kaplan, MD, PhD is a Professor within the Department of Dermatology and Immunology, University of Pittsburgh. His laboratory is currently focused on understanding how intracellular communication mechanisms between immune cells and non-hematopoietic cells in the skin modulate cutaneous immunity and skin disease. The upcoming seminar will focus on the unique contributions of individual subsets of peripheral sensory neurons to the maintenance of cutaneous homeostasis and the development of inflammation.Air date: 4/17/2024 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 18, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - IL-27: King of Cytokines
Cytokines are not inherently pro- or anti-inflammatory and the Hunter laboratory is interested in how these factors govern the development of immunity to infection but can also be involved in the prevention of immune hyperactivity. The presentation will cover the immunobiology of the cytokine IL-27, its ability to limit infection-induced pathological T cell and monocyte responses and how this pathway can be targeted as a cancer therapy. The knowledge of the biology of IL-27 can also be used to inform strategies to enhance mRNA vaccination.Air date: 4/3/2024 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 18, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
IVDs, LDTs, FDA and CLIA. Understanding the alphabet soup of laboratory assays
Laboratory assays (in vitro diagnostics, IVDs) performed on biological specimens are integral to research and clinical care. Both the FDA and CMS (CLIA) regulate laboratory assays, with distinct requirements and responsibilities. Research teams must be aware when FDA or CLIA regulations apply to the use and reporting of results from in vitro testing of biospecimens.Objectives for this session:Understand the difference between the CLIA and FDA regulationsUnderstand when an assay is an investigational device and subject to FDA regulationsUnderstand when CLIA appliesLearn about the process of obtaining CLIA certificationAir d...
Source: Videocast - All Events - March 5, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Grand Rounds: Biomaterials to Promote T Cell Immunity
CCR Grand Rounds “ Biomaterials to Promote T Cell Immunity ” David J. Mooney, Ph.D.Founding Core Faculty& Lead, Immuno-MaterialsWyss Institute at Harvard UniversityRobert P. Pinkas Family Professor of BioengineeringHarvard John A. Paulson School of Engineering and Applied SciencesFriday, March 22, 202412:00 – 1:00 p.m.Lipsett AmphitheaterDr. David J. Mooney is the Pinkas Family Professor of Bioengineering in the Harvard School of Engineering and Applied Sciences and a Core Faculty Member of the Wyss Institute. His laboratory designs biomaterials to promote regeneration and immunotherapy. He is a member o...
Source: Videocast - All Events - February 28, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH-FDA COVID-19 SIG: Building a Technical Community of Practice in the Midst of a Pandemic: The Role of SPHERES in Genomic Surveillance for SARS-CoV-2, mpox and beyond.
Duncan MacCannell is the director for the Office of Advanced Molecular Detection (OAMD) at the Centers for Disease Control and Prevention (CDC). In this role, he helps coordinate and support the implementation and expansion of pathogen genomics, molecular epidemiology, scientific computing, and the use of innovative laboratory technologies across the public health system. This includes CDC ’ s four infectious disease centers, state and local health departments throughout the United States, and a growing global network of public health, academic and private sector institutions. Dr. MacCannell is an advocate for rapid, ope...
Source: Videocast - All Events - February 21, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
Biomaterials to Promote T Cell Immunity
CCR Grand Rounds “ Biomaterials to Promote T Cell Immunity ” David J. Mooney, Ph.D.Founding Core Faculty& Lead, Immuno-MaterialsWyss Institute at Harvard UniversityRobert P. Pinkas Family Professor of BioengineeringHarvard John A. Paulson School of Engineering and Applied SciencesFriday, March 22, 202412:00 – 1:00 p.m.Lipsett AmphitheaterAlso available to view via NIH Videocast.Dr. David Mooney is the Pinkas Family Professor of Bioengineering in the Harvard School of Engineering and Applied Sciences and a Core Faculty Member of the Wyss Institute. His laboratory designs biomaterials to promote regeneration and im...
Source: Videocast - All Events - February 21, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS J. Edward Rall Cultural Lecture: The Promises and Perils of AI in Biomedical Research and Health Care Delivery
Vinton G. Cerf has served as vice president and chief Internet evangelist for Google since October 2005. In this role, he contributes to global policy development and continued standardization and spread of the Internet. He is also an active public face for Google in the Internet world.From 1994 to 2005, Cerf served as the senior vice president of Technology Strategy for MCI. In this role, Cerf was responsible for helping to guide corporate strategy development from the technical perspective. Previously, Cerf served as MCI ’ s senior vice president of Architecture and Technology, leading a team of architects and engineer...
Source: Videocast - All Events - February 12, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
Understanding Immune Responses in Strongyloides stercoralis Infection: Implications for Bystander Effects on Tuberculosis and Type 2 Diabetes
Dr. Subash Babu is a distinguished physician-scientist with over two decades of expertise at the forefront of immunological research, particularly focusing on the intersection of infectious diseases and prevalent metabolic disorders in India. As the head of the NIAID-ICER laboratory in Chennai, his multidisciplinary approach is centered on helminth infections. His lab investigates protective immunity to filarial and Strongyloides stercoralis, offering insights crucial for vaccine development. Additionally, Dr. Babu explores the mechanisms underlying filarial lymphedema and the impact of helminth infections on tuberculosis ...
Source: Videocast - All Events - February 8, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - A new molecular regulatory pathway revealed by studying a human immunodysregulatory disorder
Our laboratory aims to elucidate molecular mechanisms regulating the human immune system and delineate how their derangements cause disease. As will be exemplified in the talk, our approach is to study patients with rare and poorly characterized inherited inborn errors of immunity who are followed at the NIH Clinical Center. By carefully investigating these “ experiments of nature ” we can draw inferences about molecular functions based on patient phenotypes. Our program broadly integrates the patients ’ clinical evaluations, assessments of their immune function, genetic and biochemical analyses to gain insights into...
Source: Videocast - All Events - February 2, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
Immunological mechanisms of mRNA vaccines- NIH FDA COVID-19 SIG Lecture Series
The production of antibodies (Abs) with high affinity and pathogen neutralization potential is crucial for preventing and fighting pathogen infection. To produce such Abs, na ï ve B cells are activated in response to cognate antigen and subsequently undergo rounds of somatic hypermutation and selection in germinal centers, specialized microanatomical sites in secondary lymphoid organs. This process of affinity maturation is tightly regulated by a specialized subset of CD4 T cells named T follicular helper (Tfh) cells. Our laboratory is interested in dissecting the complex biology of Tfh cells. Understanding (1) how Tfh di...
Source: Videocast - All Events - February 2, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Chronic psychological stress and macrophage inflammation in atherosclerosis
Atherosclerosis is recognized as a chronic inflammatory disease of the arteries that initiates through normal protective functions of the innate immune system, but goes awry through the failure to resolve macrophage inflammation in the arterial plaques. Dr. Fisher ’ s laboratory has pioneered multiple mouse models in which to study inflammation resolution in atherosclerosis. He has collaborated with a number of colleagues to apply these models to study mechanisms by which certain conditions, such as diabetes, kidney disease, and obesity, increase cardiovascular risk through their interference with plaque macrophage infla...
Source: Videocast - All Events - February 1, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
