Immune Checkpoint Inhibitor-induced Polymyalgia Rheumatica
Polymyalgia rheumatica (PMR) immune-related adverse events (ICI-PMRs) represent a novel, distinct entity, despite many clinical, laboratory, and imaging similarities to classical PMR. Important questions remain in differentiating ICI-PMR from classical PMR, as well as other immune-related adverse events and PMR mimics. Despite this, ICI-PMR currently takes treatment cues from classical PMR, albeit with considerations relevant to cancer immunotherapy. Comparisons between ICI-PMR and classical PMR may provide further bidirectional insights, especially given that important questions remain unanswered about both diseases. The ...
Source: Rheumatic Disease Clinics of North America - April 25, 2024 Category: Rheumatology Authors: David F.L. Liew, Sarah L. Mackie, Alice Tison, Sebastian E. Sattui, Max Yates, Russell R.C. Buchanan, Claire E. Owen Source Type: research
Intestinal Parasitic Infections in People Referring to the Central Laboratory of Meshkin Shahr County, Ardabil Province, Iran
CONCLUSION: In- spite of betterment of the health condition in Iran and reduction of parasitic infection, intestinal parasitic infections are still a considerable public health issue in some parts of Iran.PMID:38654952 | PMC:PMC11033542 | DOI:10.18502/ijpa.v19i1.15217 (Source: Iranian Journal of Parasitology)
Source: Iranian Journal of Parasitology - April 24, 2024 Category: Parasitology Authors: Pooria Asadi Zabihollah Zarei Mehdi Mohebali Zahra Alizadeh Faezeh Najafi Shahrokh Izadi Zahra Heidari Source Type: research
Visceral Leishmaniasis (VL) Clinical Presentation, Laboratory Findings, Treatment Options and Outcome
CONCLUSION: VL should be included in the differential diagnosis of any child who presents with fever, splenomegaly, and anemia. Concerning the treatment strategy in this study, liposomal amphotericin B had more efficiency and shorter hospitalization duration.PMID:38654944 | PMC:PMC11033536 | DOI:10.18502/ijpa.v19i1.15190 (Source: Iranian Journal of Parasitology)
Source: Iranian Journal of Parasitology - April 24, 2024 Category: Parasitology Authors: Mahmoud Khodabandeh Elham Moradian Maedeh Sarvari Mahsa Soti Khiabani Source Type: research
Molecular Genotyping of < em > Giardia duodenalis < /em > in Humans in the Yazd County, Central of Iran
CONCLUSION: Assemblages A and B are the most prevalent in Central Iran. The molecular identification of G. duodenalis isolates from animals and implementing control programs.PMID:38654947 | PMC:PMC11033543 | DOI:10.18502/ijpa.v19i1.15216 (Source: Iranian Journal of Parasitology)
Source: Iranian Journal of Parasitology - April 24, 2024 Category: Parasitology Authors: Elaheh Hezardastan Ali Fattahi Bafghi Gilda Eslami Mahmoud Vakili Source Type: research
A Troublesome Complication of Hydatid Cysts; Intra-Abdominal Rupture: A 10-Year Study from a High-Volume Center
CONCLUSION: Hydatid cyst rupture should be considered in cases of acute abdomen, particularly in regions where the disease is endemic, as in our region. The ruptured hydatid cyst was primarily observed in the liver (94.11% of cases).PMID:38654950 | PMC:PMC11033535 | DOI:10.18502/ijpa.v19i1.15199 (Source: Iranian Journal of Parasitology)
Source: Iranian Journal of Parasitology - April 24, 2024 Category: Parasitology Authors: H üseyin Yönder Mehmet Sait Berhuni Hasan Elkan Abdullah Özgönül Ahmet Bertan Vedat Kaplan Ali Uzunk öy Source Type: research
In Vitro Gamma Mutagenesis Techniques in Rice (Oryza sativa L. var. Lazarroz FL)
Methods Mol Biol. 2024;2788:243-255. doi: 10.1007/978-1-0716-3782-1_14.ABSTRACTGamma radiation (60Co)-induced mutagenesis offers an alternative to develop rice lines by accelerating the spontaneous mutation process and increasing the pool of allelic variants available for breeding. Ionizing radiation works by direct or indirect damage to DNA and subsequent mutations. The technique can take advantage of in vitro protocols to optimize resources and accelerate the development of traits. This is achieved by exposing mutants to a selection agent of interest in controlled conditions and evaluating large numbers of plants in redu...
Source: Mol Biol Cell - April 24, 2024 Category: Molecular Biology Authors: Jason P érez Alejandro Hern ández-Soto Ana Abdelnour-Esquivel Walter Vargas-Segura William Watson-Guido Andr és Gatica-Arias Source Type: research
Hepatocyte-specific METTL3 ablation by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and postnatal lethality
In this study, we explored the potential reasons why hepatocyte-specific METTL3 homozygous disruption by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and then postnatal lethality.MAIN METHODS: Mice with hepatocyte-specific METTL3 knockout were generated by simultaneously crossing METTL3fl/fl mice with Alb-iCre mice (GPT; Strain No. T003814) purchased from the GemPharmatech Co., Ltd., (Nanjing, China) or with Alb-Cre mice (JAX; Strain No. 003574) obtained from The Jackson Laboratory, followed by combined-phenotype analysis. The publicly available RNA-sequencing data deposited in ...
Source: Aging - April 24, 2024 Category: Biomedical Science Authors: Shihao Huang Yingchun Li Bingjie Wang Zhihao Zhou Yonglong Li Lingjun Shen Jinge Cong Liuxin Han Xudong Xiang Jiawei Xia Danhua He Zhanlin Zhao Ying Zhou Qiwen Li Guanqi Dai Hanzhang Shen Taoyan Lin Aibing Wu Junshuang Jia Dong Xiao Jing Li Wentao Zhao Xi Source Type: research
Iron deficiency in astrocytes alters cellular status and impacts on oligodendrocyte differentiation
J Neurosci Res. 2024 Apr;102(4):e25334. doi: 10.1002/jnr.25334.ABSTRACTIron deficiency (ID) has been shown to affect central nervous system (CNS) development and induce hypomyelination. Previous work from our laboratory in a gestational ID model showed that both oligodendrocyte (OLG) and astrocyte (AST) maturation was impaired. To explore the contribution of AST iron to the myelination process, we generated an in vitro ID model by silencing divalent metal transporter 1 (DMT1) in AST (siDMT1 AST) or treating AST with Fe3+ chelator deferoxamine (DFX; DFX AST). siDMT1 AST showed no changes in proliferation but remained immatu...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Mar ía Silvina Marcora Vanesa Soledad Mattera Pilar Go ñi Florencia Aybar Jorge Daniel Correale Juana Maria Pasquini Source Type: research
Patients hospitalized with active tuberculosis and Covid-19 coinfection: A matched case-control from the Brazilian Covid-19 Registry
An Acad Bras Cienc. 2024 Apr 22;96(1):e20230791. doi: 10.1590/0001-3765202420230791. eCollection 2024.ABSTRACTAlthough control of Covid-19 has improved, the virus continues to cause infections, such as tuberculosis, that is still endemic in many countries, representing a scenario of coinfection. To compare Covid-19 clinical manifestations and outcomes between patients with active tuberculosis infection and matched controls. This is a matched case-control study based on data from the Brazilian Covid-19 Registry, in hospitalized patients aged 18 or over with laboratory confirmed Covid-19 from March 1, 2020, to March 31, 2022...
Source: An Acad Bras Cienc - April 24, 2024 Category: Science Authors: Rafael L R Carvalho Gabriella G Aguiar Jessica F B Moreira Daniella N Pereira Val éria Maria Augusto Alexandre V Schwarzbold Carolina C Matos Danyelle R A Rios Fel ício R Costa Fernando Anschau Jos é Miguel Chatkin Karen B Ruschel Marcelo Carneiro Neim Source Type: research
Cascade ring expansion reactions for the synthesis of medium-sized rings and macrocycles
Chem Commun (Camb). 2024 Apr 24. doi: 10.1039/d4cc01303d. Online ahead of print.ABSTRACTThis Feature Article discusses recent advances in the development of cascade ring expansion reactions for the synthesis of medium-sized rings and macrocycles. Cascade ring expansion reactions have much potential for use in the synthesis of biologically important medium-sized rings and macrocycles, most notably as they don't require high dilution conditions, which are commonly used in established end-to-end macrocyclisation methods. Operation by cascade ring expansion method can allow large ring products to be accessed via rearrangements...
Source: Chemical Communications - April 24, 2024 Category: Chemistry Authors: Jack M Wootton Jerry K F Tam William P Unsworth Source Type: research
Crown Ether Electrolyte Induced Li2O2 Amorphization for Low Polarization and Long Lifespan Li-O2 batteries
Angew Chem Int Ed Engl. 2024 Apr 24:e202403521. doi: 10.1002/anie.202403521. Online ahead of print.ABSTRACTLithium-oxygen batteries possess an extremely high theoretical energy density, rendering them a prime candidate for next-generation secondary batteries. However, they still face multiple problems such as huge charge polarization and poor cycle life, which lay a significant gap between laboratory research and commercial applications. In this work, we adapt 15-crown-5 ether (C15) as solvent to regulate the generation of discharge products in lithium-oxygen batteries. The coronal structure endows C15 with strong affinity...
Source: Angewandte Chemie - April 24, 2024 Category: Chemistry Authors: Meng Li Jiaxin Wu Zichang You Zhongqin Dai Yuanfan Gu Lei Shi Meifen Wu Zhaoyin Wen Source Type: research
A real ‐time signal processing software package for the electrophysiology laboratory
ConclusionWe have developed and demonstrated the feasibility of a readily scalable and open-access Python-based plug in to an electroanatomic mapping system (EnSiteX) to allow real-time processing and display of electrogram (EGM) based information for the procedural electrophysiologist to view intraprocedurally in the electrophysiology laboratory. The availability, to the clinician, of traditional and novel EGM-based metrics at the time of intervention, such as atrial fibrillation ablation, allows for key mechanistic insights into critical unresolved questions regarding arrhythmia mechanism. (Source: Journal of Cardiovascu...
Source: Journal of Cardiovascular Electrophysiology - April 24, 2024 Category: Cardiology Authors: Kathryn D. Tiver,
Campbell Strong,
Dhani Dharmaprani,
Darius Chapman,
Evan Jenkins,
Sobhan Salari Shahrbabaki,
Anand N. Ganesan Tags: BRIEF COMMUNICATION Source Type: research
Randomized investigation of the MitraClip device in heart failure: Design and rationale of the RESHAPE ‐HF2 trial design
ConclusionsThe RESHAPE-HF2 trial will provide sound evidence on the MitraClip device and its effects in HF patients with FMR. The recruitment was recently completed with 506 randomized patients. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - April 24, 2024 Category: Cardiology Authors: Stefan D. Anker,
Tim Friede,
Ralph Stephan von Bardeleben,
Javed Butler,
Kaneez Fatima,
Monika Diek,
Jutta Heinrich,
Gerd Hasenfu ß,
Wolfgang Schillinger,
Piotr Ponikowski Tags: Study Design Source Type: research
Clinical Pathologic Conference Case #6: Oral and Cutaneous Findings in a 14-year-old Female
A 14-year-old female with a history of Kawasaki disease was referred to a university oral medicine clinic by her orthodontist due to swollen, hemorrhagic gingiva and tooth mobility. Scurvy was suspected by the patient's nurse practitioner and confirmed by a measure of ascorbic acid in plasma of less than 5 μmol per liter (0.1 mg per deciliter; reference range, 23 to 114 μmol per liter [0.4 to 2.0 mg per deciliter]). Laboratory testing also revealed vitamin D deficiency with a measured 25-hydroxyvitamin D level of less than 23.3 ng per milliliter (50 nmol per liter; reference range 32.0-100.0 ng per milliliter). (Source: ...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 24, 2024 Category: ENT & OMF Authors: Sarah Glass, Mark Mintline Source Type: research
Effects of a dietary intervention on cardiometabolic risk and food consumption in a workplace
by Archana Shrestha, Dipesh Tamrakar, Bhawana Ghinanju, Deepa Shrestha, Parashar Khadka, Bikram Adhikari, Jayana Shrestha, Suruchi Waiwa, Prajjwal Pyakurel, Niroj Bhandari, Biraj Man Karmacharya, Akina Shrestha, Rajeev Shrestha, Rajendra Dev Bhatta, Vasanti Malik, Josiemer Mattei, Donna Spiegelman
BackgroundWorksite-based health programs have shown positive impacts on employee health and have led to significant improvements in cardiovascular risk factor profiles. We aimed to determine the effect of cafeteria intervention on cardio-metabolic risk factors diet in a worksite setting (Dhulikhel Hospital) in Nepal. MethodsIn th...
Source: PLoS One - April 24, 2024 Category: Biomedical Science Authors: Archana Shrestha Source Type: research
