COVID-19 and Venous Thromboembolism Risk
Conditions:   Venous Thromboembolism;   Covid19 Intervention:   Other: Laboratory test positive for SARS-CoV-2 virus Sponsors:   University of California, San Francisco;   Kaiser Permanente Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 29, 2020 Category: Research Source Type: clinical trials

An efficacy and safety study of rivaroxaban for the prevention of deep vein thrombosis in patients with left iliac vein compression treated with stent implantation (PLICTS): study protocol for a prospective randomized controlled trial
This study is a multicenter, randomized controlled trial. We will recruit 224 patients with thrombotic LIVCS from 9 hospitals. Moreover, these patients will be randomized to either the experimental group (rivaroxaban) or the control group (warfarin plus nadroparin). The primary outcome is stent occlusion rate. Secondary outcomes are quality of life scale survey results, all-cause mortality, anticoagulation-related mortality, and the proportion of participants with stent displacement/fracture, thrombosis, hemorrhage, and other vascular events.DiscussionThis study will provide reliable, evidence-based clinical evidence for t...
Source: Trials - September 29, 2020 Category: Research Source Type: clinical trials

Effects of Licorice on clinical symptoms and laboratory signs in moderately ill patients with pneumonia from COVID-19: A structured summary of a study protocol for a randomized controlled trial
This study is being conducted at Shahid Mohammadi Hospital, Bandar Abbas, Iran.ParticipantsBoth male and female patients with ≥18 years of age (≥ 35 kg of weight), admitted at the Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas for treatment, screened for the following criteria.Inclusion criteria:1. Confirmed diagnosis of SARS-CoV-2 infection (via polymerase chain reaction [PCR] and/or antibody test).2. Presenting as moderate COVID-19 pneumonia (via chest computed tomography (CT) and/or X-ray) requiring hospitalization.3. Hospitalized ≤48 hours.4. Signing informed consent and will...
Source: Trials - September 15, 2020 Category: Research Source Type: clinical trials

Cerebral Autoregulation in Pediatric ECMO (ECMOX 2)
Conditions:   Acute Respiratory Distress Syndrome (ARDS);   Cardiogenic Shock;   Cardiac Arrest Intervention:   Sponsors:   Nantes University Hospital;   Istituto Giannina Gaslini;   Pediatric Intensive Care Unit, Trousseau University Hospital, France;   Pediatric Intensive Care Unit, Necker University Hospital, France;   Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences , University of Cambridge, UK Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 14, 2020 Category: Research Source Type: clinical trials

A quadruple blind, randomised controlled trial of gargling agents in reducing intraoral viral load among hospitalised COVID-19 patients: A structured summary of a study protocol for a randomised controlled trial
This study protocol was registered atwww.clinicaltrials.gov on 10 April 2020NCT04341688.Full protocolThe full protocol is attached as an additional file, accessible from the Trials website (Additional file1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. The study protocol has been reported in accordance with the Standard Protocol Items: Recommendations for Clinical Interventional Trials (SPIRIT) guidelines (Additional file2).Fig. 1Flow diagram of study-participants ’ timeline (Source: Trials)
Source: Trials - September 14, 2020 Category: Research Source Type: clinical trials

Cerebral Autoregulation in Pediatric ECMO (ECMOX 2)
Conditions:   Acute Respiratory Distress Syndrome (ARDS);   Cardiogenic Shock;   Cardiac Arrest Intervention:   Sponsors:   Nantes University Hospital;   Istituto Giannina Gaslini;   Pediatric Intensive Care Unit, Trousseau University Hospital, France;   Pediatric Intensive Care Unit, Necker University Hospital, France;   Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences , University of Cambridge, UK Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 13, 2020 Category: Research Source Type: clinical trials

Enoxaparin for primary thromboprophylaxis in ambulatory patients with coronavirus disease-2019 (the OVID study): a structured summary of a study protocol for a randomized controlled trial
AbstractObjectivesThe OVID study will demonstrate whether prophylactic-dose enoxaparin improves survival and reduces hospitalizations in symptomatic ambulatory patients aged 50 or older diagnosed with COVID-19, a novel viral disease characterized by severe systemic, pulmonary, and vessel inflammation and coagulation activation.Trial designThe OVID study is conducted as a multicentre open-label superiority randomised controlled trial.ParticipantsInclusion Criteria1. Signed patient informed consent after being fully informed about the study ’s background.2. Patients aged 50 years or older with a positive test for SARS-...
Source: Trials - September 9, 2020 Category: Research Source Type: clinical trials

Etiologic Mechanisms, Myocardial Changes and Prognosis of Patients With MINOCA
Condition:   Myocardial Infarction With Nonobstructive Coronary Arteries Intervention:   Other: extended clinical, laboratory and instrumental examination; treatment options comparison Sponsors:   Vilnius University Hospital Santaros Klinikos;   Research Council of Lithuania Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 4, 2020 Category: Research Source Type: clinical trials

Efficacy and safety of Jia Wei Bushen Yiqi formulas as an adjunct therapy to systemic glucocorticoids on acute exacerbation of COPD: study protocol for a randomized, double-blinded, multi-center, placebo-controlled clinical trial
DiscussionBy demonstrating the advantages of utilizing TCM and an appropriate duration of systemic glucocorticoids, this effectiveness comparison trial will provide new references to physicians on how to improve the management of COPD exacerbation. The results of HPA axis and inflammation cytokine measurements will shed light on the molecular mechanisms and entail further mechanism studies.Trial registrationwww.chictr.org.cn ChiCTR1900023364. Registered on 24 May 2019. (Source: Trials)
Source: Trials - September 3, 2020 Category: Research Source Type: clinical trials

Leflunomide for the Treatment of Severe COVID-19 in Patients With a Concurrent Malignancy
Conditions:   Hematopoietic and Lymphoid Cell Neoplasm;   Malignant Solid Neoplasm;   Symptomatic COVID-19 Infection Laboratory-Confirmed Interventions:   Other: Best Practice;   Drug: Leflunomide;   Drug: Placebo Administration Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 31, 2020 Category: Research Source Type: clinical trials

Hydroxychloroquine plus personal protective equipment versus standard personal protective equipment alone for the prevention of COVID-19 infections among frontline healthcare workers: the HydrOxychloroquine Prophylaxis Evaluation(HOPE) trial: A structured summary of a study protocol for a randomized controlled trial
AbstractObjectivesTo evaluate the effect of the combination of hydroxychloroquine (HCQ) and standard personal protective equipment (PPE) compared to the use of standard personal protective equipment alone on the proportion of laboratory confirmed COVID-19 infections among frontline healthcare workers(HCWs) in IndiaTrial designHOPE is an investigator initiated multi-centre open-label parallel group randomized controlled trial.ParticipantsAll HCWs currently working in an environment with direct exposure to patients with confirmed COVID-19 infection are eligible to participate in the trial. The trial aims to be conducted acro...
Source: Trials - August 31, 2020 Category: Research Source Type: clinical trials

Efficacy of Hwangryunhaedok-tang (Huang-lian-jie-du-tang, Oren-gedoku-to) for patients with hyperlipidemia: a study protocol for a randomized, double-blind, placebo-controlled, parallel, investigator-initiated clinical trial
This study aims to explore the feasibility, effectiveness, and safety of HHT for hyperlipidemia treatment.MethodsThis is a study protocol for a randomized, double-blind, placebo-controlled, parallel, investigator-initiated, pilot clinical trial held in Daejeon, Republic of Korea. Thirty patients with hyperlipidemia will be randomly allocated to HHT or placebo granule groups in equal proportions. Participants will be administered HHT or placebo granules three times per day for 8  weeks and followed up for another 4 weeks. The primary outcome is low-density lipoprotein cholesterol at 8 weeks from the com...
Source: Trials - August 27, 2020 Category: Research Source Type: clinical trials

Mechanisms of Blood Pressure Dysfunction in Transmen Receiving Testosterone
Conditions:   Transgender Men;   Blood Pressure;   Hyperandrogenism Intervention:   Other: Trans men Sponsors:   Yale University;   The John B. Pierce Laboratory Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 24, 2020 Category: Research Source Type: clinical trials