JL1 Antigen Expression on Bone Marrow Lymphoma Cells from Patients With Non-Hodgkin Lymphoma.
CONCLUSIONS: JL1 positivity was associated with superior complete response and less BM involvement in NHL following chemotherapy. PMID: 31432632 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Performance of Copeptin for Early Diagnosis of Acute Myocardial Infarction in an Emergency Department Setting.
CONCLUSIONS: The combination of TnI and copeptin improves AMI diagnostic performance in patients with early-onset chest pain in an ED setting. PMID: 31432633 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Development of Tigecycline Resistance in Carbapenemase-Producing Klebsiella pneumoniae Sequence Type 147 via AcrAB Overproduction Mediated by Replacement of the ramA Promoter.
CONCLUSIONS: The K. pneumoniae isolate developed tigecycline resistance during tigecycline treatment. It was related to the overexpression of the AcrAB resistance-nodulation-cell division efflux system due to promoter replacement. PMID: 31432634 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Adjustment of Modified Carbapenem Inactivation Method Conditions for Rapid Detection of Carbapenemase-Producing Acinetobacter baumannii.
CONCLUSIONS: We established optimal mCIM conditions for simple, accurate, and reproducible detection of carbapenemase-producing A. baumannii. PMID: 31432635 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

A Novel Mismatched PCR-Restriction Fragment Length Polymorphism Assay for Rapid Detection of gyrA and parC Mutations Associated With Fluoroquinolone Resistance in Acinetobacter baumannii.
CONCLUSIONS: This assay specifically amplified gyrA and parC from A. baumannii and detected A. baumannii gyrA and parC mutations with FQ resistance. PMID: 31432636 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Performance Evaluation of a New Automated Chemiluminescent Immunoanalyzer-Based Interferon-Gamma Releasing Assay AdvanSure I3 in Comparison With the QuantiFERON-TB Gold In-Tube Assay.
CONCLUSIONS: CLIA-IGRA is a reliable assay for LTBI diagnosis, with performance similar to that of QFT-GIT. PMID: 31432637 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Clinical Usefulness of Cancer Antigen (CA) 125, Human Epididymis 4, and CA72-4 Levels and Risk of Ovarian Malignancy Algorithm Values for Diagnosing Ovarian Tumors in Korean Patients With and Without Endometriosis.
Authors: Shin KH, Kim HH, Kwon BS, Suh DS, Joo JK, Kim KH Abstract BACKGROUND: Tumor markers are useful for detection and preoperative evaluation of ovarian tumors. We evaluated the clinical usefulness of cancer antigen (CA) 125, human epididymis 4 (HE4), and CA72-4 levels and Risk of Ovarian Malignancy Algorithm (ROMA) values for differential diagnosis of malignant and borderline tumors among suspected ovarian tumors, and the effects of endometriosis on these tumor markers. METHODS: In a total of 266 patients (213, 14, and 39 with benign, borderline and malignant tumors, respectively), CA125, HE4, and CA72-4 l...
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Human B1 Cells are the Main Blood Group A-Specific B Cells That Have a Moderate Correlation With Anti-A Antibody Titer.
CONCLUSIONS: Human B1 cells are the key blood group A-specific B cells that have a moderate correlation with anti-A antibody titer and therefore constitute a potential therapeutic target for successful ABO-incompatible transplantation. PMID: 31432639 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus in Korea: High Rate of False Resistance to Linezolid by the VITEK 2 System.
Authors: Yoo IY, Kang OK, Shim HJ, Huh HJ, Lee NY Abstract As various linezolid resistance mechanisms have been identified in methicillin-resistant Staphylococcus aureus (MRSA), we investigated the molecular characteristics of MRSA with elevated linezolid minimum inhibitory concentrations (MICs), using the VITEK 2 system (bioMérieux, Marcy-l'Étoile, France). Twenty-seven MRSA isolates from 14 patients exhibiting linezolid MICs ≥8 μg/mL were examined by broth microdilution (BMD) test as well as by sequencing for mutations in the 23S rRNA gene or ribosomal proteins (L3, L4, and L22) and the presen...
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Comparison of 16S Ribosomal RNA Targeted Sequencing and Culture for Bacterial Identification in Normally Sterile Body Fluid Samples: Report of a 10-Year Clinical Laboratory Review.
Authors: Yoo IY, Kang OK, Lee MK, Kim YJ, Cho SY, Huh K, Kang CI, Chung DR, Peck KR, Huh HJ, Lee NY Abstract As 16S ribosomal RNA (rRNA)-targeted sequencing can detect DNA from non-viable bacteria, it can be used to identify pathogens from clinical samples even in patients pretreated with antibiotics. We compared the results of 16S rRNA-targeted sequencing and culture for identifying bacterial species in normally sterile body fluid (NSBF): cerebrospinal, pericardial, peritoneal and pleural fluids. Over a 10-year period, a total of 312 NSBF samples were evaluated simultaneously using 16S rRNA-targeted sequencing and...
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Evaluating Diagnostic Tests for Helicobacter pylori Infection Without a Reference Standard: Use of Latent Class Analysis.
Authors: Jekarl DW, Choi H, Kim JY, Lee S, Gweon TG, Lee HK, Kim Y Abstract Evaluation of diagnostic tests requires reference standards, which are often unavailable. Latent class analysis (LCA) can be used to evaluate diagnostic tests without reference standards, using a combination of observed and estimated results. Conditionally independent diagnostic tests for Helicobacter pylori infection are required. We used LCA to construct a reference standard and evaluate the capability of non-invasive tests (stool antigen test and serum antibody test) to diagnose H. pylori infection compared with the conventional method, ...
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Performance Evaluation of the QXDx BCR-ABL %IS Droplet Digital PCR Assay.
In conclusion, the QXDx BCR-ABL %IS ddPCR assay can provide reliable results for CML patients. PMID: 31432643 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

First Case of Double T-Cell Receptor Alpha/Delta Rearrangements of t(11;14) and inv(14) and Subsequent JAK2 Rearrangement in a Patient With T-cell Acute Lymphoblastic Leukemia.
Authors: Seol CA, Cho YU, Jang S, Park CJ, Lee JH, Seo EJ PMID: 31432644 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

The First Korean Case of Epstein-Barr Virus-positive Natural Killer/T-cell Lymphoma That Progressed From Severe Mosquito Bite Allergy, With Coexistence of Hemophagocytic Lymphohistiocytosis.
Authors: Lee S, Park CJ, Cho YU, Jang S, Huh J, Kim H PMID: 31432645 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Five Korean Cases of Respiratory Tract Infection by Filamentous Basidiomycetes.
Authors: Lee JM, Han E, Kim J, Park JH, Sung GH, Shin JH, Park YJ PMID: 31432646 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Relationship of Circulating Cytomegalovirus Levels Obtained Through Antigenemia Testing and Quantitative PCR Differs Between Children and Adults.
Authors: Choi S, Kim YJ, Yoo KH, Sung KW, Koo HH, Kim SJ, Jang JH, Kim K, Jung CW, Huh HJ, Kang ES PMID: 31432647 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Laboratory Investigation of the 900-km Lapland Extreme Challenge.
Authors: Stenner E, Giovannella L, Raffaelli G, Delbello G, Ruscio M, Verna R PMID: 31432648 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Current Aspects of Clonal Hematopoiesis: Implications for Clinical Diagnosis.
Authors: Karner K, George TI, Patel JL Abstract The broad dissemination of next-generation sequencing capability has increased recognition of clonal hematopoiesis in various clinical settings. In hematologically normal individuals, somatic mutations may occur at an increasing frequency with age in genes that are also commonly mutated in overt myeloid malignancies such as AML and MDS (e.g., DNMT3A, TET2, and ASXL1). This is referred to as clonal hematopoiesis of indeterminate potential (CHIP) and is a benign state; however, it carries a risk of progression to hematologic malignancy as well as mortality primarily bec...
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Korean Society for Genetic Diagnostics Guidelines for Validation of Next-Generation Sequencing-Based Somatic Variant Detection in Hematologic Malignancies.
This article presents guidelines developed through consensus among a panel of experts from the Korean Society for Genetic Diagnostics. They are based on experiences with the validation processes of NGS-based somatic panels for hematologic malignancies, with reference to previous international recommendations. These guidelines describe basic parameters with emphasis on the design of a validation protocol for NGS-based somatic panels to be used in practice. In addition, they suggest thresholds of key metrics, including minimum coverage, mean coverage with uniformity index, and minimum variant allele frequency, for the initia...
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Screening for Gestational Diabetes Mellitus by Measuring Glycated Hemoglobin Can Reduce the Use of the Glucose Challenge Test.
CONCLUSIONS: HbA1c can be used as a screening test prior to the GCT, thereby reducing the need for the GCT among pregnant women at a low risk of GDM. PMID: 31240879 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Application of the Whole Genome-Based Bacterial Identification System, TrueBac ID, Using Clinical Isolates That Were Not Identified With Three Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) Systems.
CONCLUSIONS: TrueBac ID successfully identified the majority of isolates that MALDI-TOF MS failed to identify. Genome-based identification can be a useful tool in clinical laboratories, with its superior accuracy and database-driven operations. PMID: 31240880 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Serotype Distribution and Antimicrobial Resistance of Invasive and Noninvasive Streptococcus pneumoniae Isolates in Korea between 2014 and 2016.
CONCLUSIONS: There were significant changes in the major S. pneumoniae serotypes in the community. Non-PCV13 serotypes increased in patients ≤5 years old following the introduction of national immunization programs with the 10- and 13-polyvalent vaccines. PMID: 31240881 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Molecular Genetics of von Willebrand Disease in Korean Patients: Novel Variants and Limited Diagnostic Utility of Multiplex Ligation-Dependent Probe Amplification Analyses.
CONCLUSIONS: This study revealed the spectrum of VWF variants, including novel ones, and limited diagnostic utility of MLPA analyses in Korean patients with VWD. PMID: 31240882 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Development of Statistical Software for the Korean Laboratory Accreditation Program Using R Language: LaboStats.
CONCLUSIONS: LaboStats can be useful for evaluating clinical test performance characteristics and preparing documents requested by KLAP. PMID: 31240883 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

POEMS Syndrome: Bone Marrow, Laboratory, and Clinical Findings in 24 Korean Patients.
Authors: Shim H, Seol CA, Park CJ, Cho YU, Seo EJ, Lee JH, Yoon DH, Suh CW, Park SH, Jang S Abstract POEMS syndrome is a rare paraneoplastic syndrome, which includes polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes due to plasma cell (PC) neoplasm. Diagnosis of this disease is challenging because of its rarity and complex clinical manifestations. We attempted to identify the key clinical features and characteristic bone marrow (BM) findings of POEMS syndrome, by reviewing the medical records and BM analyses of 24 Korean patients. Frequent clinical manifestations included polyneuropathy (100...
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Comparison of Six Commercial Diagnostic Tests for the Detection of Dengue Virus Non-Structural-1 Antigen and IgM/IgG Antibodies.
Authors: Lee H, Ryu JH, Park HS, Park KH, Bae H, Yun S, Choi AR, Cho SY, Park C, Lee DG, Lim J, Lee J, Lee S, Shin S, Park H, Oh EJ Abstract ELISAs and rapid diagnostic tests (RDTs) are widely used for diagnosing dengue virus (DENV) infection. Using 138 single blood samples, we compared the ability to detect non-structural (NS)-1 antigen and anti-DENV IgM/IgG antibodies among (1) DENV Detect NS1 ELISA, DENV Detect IgM capture ELISA and DENV Detect IgG ELISA (InBios International, Inc.); (2) Anti-Dengue virus IgM Human ELISA and Anti-Dengue virus IgG Human ELISA (Abcam); (3) Dengue virus NS1 ELISA, Anti-Dengue virus...
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

EDTA Treatment for Overcoming the Prozone Effect and for Predicting C1q Binding in HLA Antibody Testing.
Authors: Kim HS, Choi AR, Yang M, Oh EJ Abstract The Luminex-based single antigen bead (SAB) assay is widely used to detect HLA antibody in transplant recipients. However, one limitation of the SAB assay is the prozone effect, which occurs mostly as a result of complement interference. We investigated the efficacy of EDTA treatment for overcoming the prozone effect and predicting C1q binding of HLA antibody. We subjected 27 non-treated (naïve) and EDTA-treated serum samples from highly sensitized patients to IgG-SAB assays, and we confirmed the prozone effect in 53% and 31% of class I and class II antibody tes...
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

First Case of Transformation of Immunoglobulin Heavy Chain Variable-Mutated Chronic Lymphocytic Leukemia Into Chronic Myeloid Leukemia.
Authors: Zhang X, Guo X PMID: 31240887 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Fluoranthene-Induced Cytotoxicity and Direct Effect of Aryl Hydrocarbon Receptor Antagonist on Hematopoietic Stem Cell Differentiation.
Authors: Yang SH, Kang MG, Kim HR, Lee YE, Na BR, Lee JH, Shin JH, Shin MG PMID: 31240888 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Improvement in External Quality Assessment Results for Qualitative Fecal Immunochemical Tests in Korea After Feedback to Manufacturers.
Authors: Lee W, Ryoo N, Suh HS, Jeon CH, Urinalysis and Routine Microscopy Subcommittee, Korean Association of External Quality Assessment Service PMID: 31240889 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

First Case of Aureimonas altamirensis Bacteremia in Korea.
Authors: Kim N, Hwang JH, Cho YG, Kim DS, Lee HS, Lee J PMID: 31240890 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Accuracy of BacT/Alert Virtuo for Measuring Blood Volume for Blood Culture.
Authors: Lee S, Kim S PMID: 31240891 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

First Case of Trueperella bernardiae Bacteremia in an Immunocompromised Patient in Korea.
Authors: Roh J, Kim M, Kim D, Yong D, Lee K PMID: 31240892 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

First Isolation of Mycobacterium virginiense From a Human Pulmonary Specimen.
Authors: Jung J, Yoo IY, Jhun BW, Koh WJ, Lee NY, Huh HJ PMID: 31240893 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Pitfalls of ABO Genotyping Based on Targeted Single Nucleotide Variant Analysis Due to a Nondeletional O Allele Lacking c.261delG: First Report of ABO*O.09.01 in Korea.
Authors: Yang D, Kim B, Song DY, Kim TY, Kim MJ, Cho SI, Kim H, Seong MW, Park SS PMID: 31240894 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

First Case in Korea of a Patient With Anti-PP1Pk Antibodies: Successful Blood Management via Acute Normovolemic Hemodilution.
Authors: Ha C, Choi S, Yu H, Chun S, Kim KH, Lee JH, Han IW, Cho D PMID: 31240895 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Erratum: Challenges and Considerations in Sequence Variant Interpretation for Mendelian Disorders.
Authors: Kim YE, Ki CS, Jang MA Abstract This corrects the article on p. 421 in vol. 39, PMID: 31037860. PMID: 31240896 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - June 28, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Challenges and Considerations in Sequence Variant Interpretation for Mendelian Disorders.
We describe the critical elements of variant interpretation processes and potential pitfalls through practical examples and provide updated information based on a review of recent literature. The variant classification we describe is meant to be applicable to sequence variants for Mendelian disorders, whether identified by single-gene tests, multi-gene panels, exome sequencing, or genome sequencing. Continuing efforts to improve the reproducibility and objectivity of sequence variant interpretation across individuals and laboratories are needed. PMID: 31037860 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - May 2, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Flow Cytometric Analysis of T Cells in Hemophagocytic Lymphohistiocytosis.
CONCLUSIONS: An aberrant T cell immunophenotype may assist in discriminating EBV-negative secondary HLH and EBV-positive HLH. However, it may not be useful as a prognostic marker. PMID: 31037861 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - May 2, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Clonal Cell Proliferation in Paroxysmal Nocturnal Hemoglobinuria: Evaluation of PIGA Mutations and T-cell Receptor Clonality.
CONCLUSIONS: PIGA mutations were present in approximately 80% of PNH patients. PNH clone size varies according to blood cell lineage, and clonal cells may obtain proliferation potential or gain a survival advantage over normal cells. PMID: 31037862 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - May 2, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Use of Liquid Chromatography-Tandem Mass Spectrometry for Clinical Testing in Korean Laboratories: a Questionnaire Survey.
CONCLUSIONS: LC-MS/MS has been successfully introduced in Korean clinical laboratories and is used within a quality framework. Further efforts for harmonization on a nationwide basis could facilitate the widespread use of LC-MS/MS. PMID: 31037863 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - May 2, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Circulating Biologically Active Adrenomedullin Predicts Organ Failure and Mortality in Sepsis.
Authors: Kim H, Hur M, Struck J, Bergmann A, Di Somma S Abstract BACKGROUND: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Biologically active adrenomedullin (bio-ADM) is an emerging biomarker for sepsis. We explored whether bio-ADM concentration could predict severity, organ failure, and 30-day mortality in septic patients. METHODS: In 215 septic patients (109 patients with sepsis; 106 patients with septic shock), bio-ADM concentration was measured at diagnosis of sepsis, using sphingotest bio-ADM (Sphingotec GmbH, Hennigsdorf, Germany) and analyzed in term...
Source: Annals of Laboratory Medicine - May 2, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Performance of the cobas u 701 Analyzer in Urinary Tract Infection Screening.
CONCLUSIONS: cobas u 701 can substantially reduce the number of urine samples requiring culture, with a low false-negative rate and a high NPV. PMID: 31037865 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - May 2, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Performance Evaluation of the Newly Developed BD Phoenix NMIC-500 Panel Using Clinical Isolates of Gram-Negative Bacilli.
CONCLUSIONS: The BD Phoenix NMIC-500 panel shows promise for AST and CPO detection. PMID: 31037866 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - May 2, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Comparison of cobas EGFR Mutation Test v2 and PANAMutyper-R-EGFR for Detection and Semi-Quantification of Epidermal Growth Factor Receptor Mutations in Plasma and Pleural Effusion Supernatant.
Authors: Han AL, Kim HR, Choi KH, Hwang KE, Zhu M, Huang Y, Wu M, Lee YJ, Park MC, Cho JH, Park DS Abstract BACKGROUND: Plasma epidermal growth factor receptor (EGFR) mutation tests are less invasive than tissue EGFR mutation tests. We determined which of two kits is more efficient: cobas EGFR Mutation test v2 (cobasv2; Roche Molecular Systems, Pleasanton, CA, USA) or PANAMutyper-R-EGFR (Mutyper; Panagene, Daejeon, Korea). We also evaluated whether pleural effusion supernatant (PE-SUP) samples are assayable, similar to plasma samples, using these two kits. METHODS: We analyzed 156 plasma and PE-SUP samples (31 ...
Source: Annals of Laboratory Medicine - May 2, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Comparison of Characteristics of Streptococcus dysgalactiae subsp. equisimilis Isolates Causing Repetitive vs Single Infections.
In conclusion, clinicians encountering patients with repetitive infections should be aware of both possibilities: recurrence with closely related strains and reinfection with different strains. PMID: 31037868 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - May 2, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

First Report of a Patient With Natural Killer-Lymphoblastic Leukemia/Lymphoma in Korea.
Authors: Lee J, Kim HY, Han B, Kim M, Park JY, Chung Y, Lee YK PMID: 31037869 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - May 2, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Two Rare Cases of Therapy-Related Acute Lymphoblastic Leukemia in Patients With Plasma Cell Myeloma.
Authors: Lee HY, Park CJ, Ahn A, Lee MY, Cho YU, Jang S, Seo EJ, Lee KH, Lee JH PMID: 31037870 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - May 2, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Letter: Eliminating or Minimizing the Effects of Cold Agglutinins on the Accuracy of Complete Blood Count Results.
Authors: La Gioia A PMID: 31037871 [PubMed - indexed for MEDLINE] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - May 2, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Correspondence: Response to "Eliminating or Minimizing the Effects of Cold Agglutinins on the Accuracy of Complete Blood Count Results".
Correspondence: Response to "Eliminating or Minimizing the Effects of Cold Agglutinins on the Accuracy of Complete Blood Count Results". Ann Lab Med. 2019 Sep;39(5):501-502 Authors: Rim JH, Yoo J PMID: 31037872 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - May 2, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research