Identification of Potential Genomic Alterations Using Pan-Cancer Cell-Free DNA Next-Generation Sequencing in Patients With Gastric Cancer
CONCLUSIONS: Next-generation sequencing of cfDNA is a promising technique for the molecular profiling of GC. Evidence suggests that cfDNA analysis can provide accurate and reliable information on somatic genomic alterations in patients with GC, potentially replacing tissue biopsy as a diagnostic and prognostic tool. Through cfDNA analysis for molecular profiling, it may be possible to translate the molecular classification into therapeutic targets and predictive biomarkers, leading to personalized treatment options for patients with GC in the future.PMID:37903652 | DOI:10.3343/alm.2023.0187 (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - October 30, 2023 Category: Laboratory Medicine Authors: Boyeon Kim Yoonjung Kim Jae Yong Cho Kyung-A Lee Source Type: research
Evaluation of a Modified Protocol for the SepsiPrep Kit for Direct Identification and Antimicrobial Susceptibility Testing From Positive Blood Culture Using BACTEC Plus and BacT/Alert Blood Culture Bottles
Ann Lab Med. 2023 Oct 30. doi: 10.3343/alm.2023.0294. Online ahead of print.NO ABSTRACTPMID:37903653 | DOI:10.3343/alm.2023.0294 (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - October 30, 2023 Category: Laboratory Medicine Authors: In Young Yoo Sung Il Ha Hee Jae Huh Tae Yeul Kim Hyang Jin Shim Hyeyoung Lee Jayoung Kim Nam Yong Lee Yeon-Joon Park Source Type: research
Head-to-Head Comparison of Nine Assays for the Detection of Anti- < em > Echinococcus < /em > Antibodies: A Retrospective Evaluation
CONCLUSIONS: Echinococcus serological assays are highly variable in terms of sensitivity and specificity. Knowledge of the pre-test probability in the patient cohort is required to choose a suitable assay. A combined approach with screening and confirmatory assays may be the best diagnostic strategy in many situations.PMID:37880992 | DOI:10.3343/alm.2023.0212 (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - October 26, 2023 Category: Laboratory Medicine Authors: Carolina Mattwich Kristina Huber Gisela Bretzel Sebastian Suerbaum Andreas Wieser Karl Dichtl Source Type: research
Next-Generation Sequencing-Based Molecular Profiling Using Cell-Free DNA: A Valuable Tool for the Diagnostic and Prognostic Evaluation of Patients With Gastric Cancer
Ann Lab Med. 2023 Oct 26. doi: 10.3343/alm.2023.0391. Online ahead of print.NO ABSTRACTPMID:37880993 | DOI:10.3343/alm.2023.0391 (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - October 26, 2023 Category: Laboratory Medicine Authors: Mi-Ae Jang Source Type: research
Head-to-Head Comparison of Nine Assays for the Detection of Anti- < em > Echinococcus < /em > Antibodies: A Retrospective Evaluation
CONCLUSIONS: Echinococcus serological assays are highly variable in terms of sensitivity and specificity. Knowledge of the pre-test probability in the patient cohort is required to choose a suitable assay. A combined approach with screening and confirmatory assays may be the best diagnostic strategy in many situations.PMID:37880992 | DOI:10.3343/alm.2023.0212 (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - October 26, 2023 Category: Laboratory Medicine Authors: Carolina Mattwich Kristina Huber Gisela Bretzel Sebastian Suerbaum Andreas Wieser Karl Dichtl Source Type: research
Next-Generation Sequencing-Based Molecular Profiling Using Cell-Free DNA: A Valuable Tool for the Diagnostic and Prognostic Evaluation of Patients With Gastric Cancer
Ann Lab Med. 2023 Oct 26. doi: 10.3343/alm.2023.0391. Online ahead of print.NO ABSTRACTPMID:37880993 | DOI:10.3343/alm.2023.0391 (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - October 26, 2023 Category: Laboratory Medicine Authors: Mi-Ae Jang Source Type: research
Head-to-Head Comparison of Nine Assays for the Detection of Anti- < em > Echinococcus < /em > Antibodies: A Retrospective Evaluation
CONCLUSIONS: Echinococcus serological assays are highly variable in terms of sensitivity and specificity. Knowledge of the pre-test probability in the patient cohort is required to choose a suitable assay. A combined approach with screening and confirmatory assays may be the best diagnostic strategy in many situations.PMID:37880992 | DOI:10.3343/alm.2023.0212 (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - October 26, 2023 Category: Laboratory Medicine Authors: Carolina Mattwich Kristina Huber Gisela Bretzel Sebastian Suerbaum Andreas Wieser Karl Dichtl Source Type: research
Next-Generation Sequencing-Based Molecular Profiling Using Cell-Free DNA: A Valuable Tool for the Diagnostic and Prognostic Evaluation of Patients With Gastric Cancer
Ann Lab Med. 2023 Oct 26. doi: 10.3343/alm.2023.0391. Online ahead of print.NO ABSTRACTPMID:37880993 | DOI:10.3343/alm.2023.0391 (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - October 26, 2023 Category: Laboratory Medicine Authors: Mi-Ae Jang Source Type: research
Head-to-Head Comparison of Nine Assays for the Detection of Anti- < em > Echinococcus < /em > Antibodies: A Retrospective Evaluation
CONCLUSIONS: Echinococcus serological assays are highly variable in terms of sensitivity and specificity. Knowledge of the pre-test probability in the patient cohort is required to choose a suitable assay. A combined approach with screening and confirmatory assays may be the best diagnostic strategy in many situations.PMID:37880992 | DOI:10.3343/alm.2023.0212 (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - October 26, 2023 Category: Laboratory Medicine Authors: Carolina Mattwich Kristina Huber Gisela Bretzel Sebastian Suerbaum Andreas Wieser Karl Dichtl Source Type: research
Next-Generation Sequencing-Based Molecular Profiling Using Cell-Free DNA: A Valuable Tool for the Diagnostic and Prognostic Evaluation of Patients With Gastric Cancer
Ann Lab Med. 2023 Oct 26. doi: 10.3343/alm.2023.0391. Online ahead of print.NO ABSTRACTPMID:37880993 | DOI:10.3343/alm.2023.0391 (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - October 26, 2023 Category: Laboratory Medicine Authors: Mi-Ae Jang Source Type: research
The Use of Bone-Turnover Markers in Asia-Pacific Populations
Ann Lab Med. 2023 Oct 23. doi: 10.3343/alm.2023.0214. Online ahead of print.ABSTRACTBone-turnover marker (BTM) measurements in the blood or urine reflect the bone-remodeling rate and may be useful for studying and clinically managing metabolic bone diseases. Substantial evidence supporting the diagnostic use of BTMs has accumulated in recent years, together with the publication of several guidelines. Most clinical trials and observational and reference-interval studies have been performed in the Northern Hemisphere and have mainly involved Caucasian populations. This review focuses on the available data for populations fro...
Source: Annals of Laboratory Medicine - October 23, 2023 Category: Laboratory Medicine Authors: Samuel Vasikaran Subashini C Thambiah Rui Zhen Tan Tze Ping Loh APFCB Harmonization of Reference Interval Working Group Source Type: research
A Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneously Determining Meropenem and Linezolid in Blood and Cerebrospinal Fluid
Ann Lab Med. 2023 Oct 23. doi: 10.3343/alm.2023.0250. Online ahead of print.ABSTRACTAntibiotic therapy requires appropriate dosage of drugs for effective treatment. Too low antibiotic concentrations may lead to treatment failure and the development of resistant pathogens, whereas overdosing may cause neurological side effects or hemolytic diseases. Meropenem and linezolid are used only in the treatment of serious infections or when other antibiotics are no longer effective as well as for treating central nervous system infections. It is difficult or sometimes even impossible to predict the relation between dosing of antibi...
Source: Annals of Laboratory Medicine - October 23, 2023 Category: Laboratory Medicine Authors: Joanna Berska Jolanta Bugajska Krystyna Sztefko Source Type: research
The LEAP Checklist for Laboratory Evaluation and Analytical Performance Characteristics Reporting of Clinical Measurement Procedures
Ann Lab Med. 2023 Oct 23. doi: 10.3343/alm.2023.0342. Online ahead of print.ABSTRACTReporting a measurement procedure and its analytical performance following method evaluation in a peer-reviewed journal is an important means for clinical laboratory practitioners to share their findings. It also represents an important source of evidence base to help others make informed decisions about their practice. At present, there are significant variations in the information reported in laboratory medicine journal publications describing the analytical performance of measurement procedures. These variations also challenge authors, r...
Source: Annals of Laboratory Medicine - October 23, 2023 Category: Laboratory Medicine Authors: Tze Ping Loh Brian R Cooke Thi Chi Mai Tran Corey Markus Rosita Zakaria Chung Shun Ho Elvar Theodorsson Ronda F Greaves IFCC Working Group on Method Evaluation Protocols (WG-MEP) Source Type: research
The Use of Bone-Turnover Markers in Asia-Pacific Populations
Ann Lab Med. 2023 Oct 23. doi: 10.3343/alm.2023.0214. Online ahead of print.ABSTRACTBone-turnover marker (BTM) measurements in the blood or urine reflect the bone-remodeling rate and may be useful for studying and clinically managing metabolic bone diseases. Substantial evidence supporting the diagnostic use of BTMs has accumulated in recent years, together with the publication of several guidelines. Most clinical trials and observational and reference-interval studies have been performed in the Northern Hemisphere and have mainly involved Caucasian populations. This review focuses on the available data for populations fro...
Source: Annals of Laboratory Medicine - October 23, 2023 Category: Laboratory Medicine Authors: Samuel Vasikaran Subashini C Thambiah Rui Zhen Tan Tze Ping Loh APFCB Harmonization of Reference Interval Working Group Source Type: research
