Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) - Lifileucel (Amtagvi)
Med Sci Monit. 2024 May 1;30:e944927. doi: 10.12659/MSM.944927.ABSTRACTOn February 16, 2024, the US Food and Drug Agency (FDA) granted accelerated approval to lifileucel (Amtagvi), an adoptive immune cell therapy with autologous ex vivo-expanded tumor-infiltrating lymphocytes (TILs) for adult patients with advanced or unresectable melanoma progressing after treatment with immune checkpoint inhibitors and, if BRAF V600 mutation-positive, BRAF/MEK inhibitors. The clinical studies supporting this regulatory approval have highlighted the complexity of the treatment manufacturing process and the requirements for patient selecti...
Source: Medical Science Monitor - May 1, 2024 Category: Research Authors: Dinah V Parums Source Type: research
Mechanisms of tumor immunosuppressive microenvironment formation in esophageal cancer
World J Gastroenterol. 2024 Apr 28;30(16):2195-2208. doi: 10.3748/wjg.v30.i16.2195.ABSTRACTAs a highly invasive malignancy, esophageal cancer (EC) is a global health issue, and was the eighth most prevalent cancer and the sixth leading cause of cancer-related death worldwide in 2020. Due to its highly immunogenic nature, emer-ging immunotherapy approaches, such as immune checkpoint blockade, have demonstrated promising efficacy in treating EC; however, certain limitations and challenges still exist. In addition, tumors may exhibit primary or acquired resistance to immunotherapy in the tumor immune microenvironment (TIME); ...
Source: World Journal of Gastroenterology - May 1, 2024 Category: Gastroenterology Authors: Xiao-Jun Zhang Yan Yu He-Ping Zhao Lei Guo Kun Dai Jing Lv Source Type: research
A novel mitochondrial unfolded protein response-related risk signature to predict prognosis, immunotherapy and sorafenib sensitivity in hepatocellular carcinoma
AbstractHepatocellular carcinoma (HCC) is a common cause of cancer-associated death worldwide. The mitochondrial unfolded protein response (UPRmt) not only maintains mitochondrial integrity but also regulates cancer progression and drug resistance. However, no study has used the UPRmt to construct a prognostic signature for HCC. This work aimed to establish a novel signature for predicting patient prognosis, immune cell infiltration, immunotherapy, and chemotherapy response based on UPRmt-related genes (MRGs). Transcriptional profiles and clinical information were obtained from the TCGA and ICGC databases. Cox regression a...
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
PANoptosis subtypes predict prognosis and immune efficacy in gastric cancer
AbstractPANoptosis is a form of inflammatory programmed cell death that is regulated by the PANoptosome. This PANoptosis possesses key characteristics of pyroptosis, apoptosis, and necroptosis, yet cannot be fully explained by any of these cell death modes. The unique nature of this cell death mechanism has garnered significant interest. However, the specific role of PANoptosis-associated features in gastric cancer (GC) is still uncertain. Patients were categorized into different PAN subtypes based on the expression of genes related to the PANoptosome. We conducted a systematic analysis to investigate the variations in pro...
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
The effects of HIV and oncogenic human papillomavirus on the tumor immune microenvironment of penile squamous cell carcinoma
In conclusion, the tumor microenvironment of penile squamous cell carcinoma seems to be affected by both HIV and HPV infections. TIM3 appears to be a potential therapeutic target in PSCC pat ients with hrHPV infections. (Source: PLoS One)
Source: PLoS One - May 1, 2024 Category: Biomedical Science Authors: Chibamba Mumba Source Type: research
The immunosuppressive landscape in tumor microenvironment
AbstractRecent advances in cancer immunotherapy, especially immune checkpoint inhibitors (ICIs), have revolutionized the clinical outcome of many cancer patients. Despite the fact that impressive progress has been made in recent decades, the response rate remains unsatisfactory, and many patients do not benefit from ICIs. Herein, we summarized advanced studies and the latest insights on immune inhibitory factors in the tumor microenvironment. Our in-depth discussion and updated landscape of tumor immunosuppressive microenvironment may provide new strategies for reversing tumor immune evasion, enhancing the efficacy of ICIs...
Source: Immunologic Research - May 1, 2024 Category: Allergy & Immunology Source Type: research
High tumor infiltrating lymphocytes are significantly associated with pathological complete response in triple negative breast cancer treated with neoadjuvant KEYNOTE-522 chemoimmunotherapy
ConclusionOur real-world data demonstrates high TIL is significantly associated with pCR rate in the K522 regimen and may potentially serve as a biomarker to select optimal treatment. The pCR rate of 48.4% in our study is lower than that reported in K522, potentially due to the smaller size of our study; however, this may also indicate differences between real-world data and clinical trial results. Larger studies are warranted to further investigate the role of immune cells in TNBC response to K522 and other treatment regimens. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - May 1, 2024 Category: Cancer & Oncology Source Type: research
Modulating extracellular matrix stiffness: a strategic approach to boost cancer immunotherapy
Cell Death & Disease, Published online: 01 May 2024; doi:10.1038/s41419-024-06697-4Modulating extracellular matrix stiffness: a strategic approach to boost cancer immunotherapy (Source: Cell death and disease)
Source: Cell death and disease - May 1, 2024 Category: Internal Medicine Authors: Zizhao Mai Yunfan Lin Pei Lin Xinyuan Zhao Li Cui Source Type: research
Treatment of Hemimasticatory Spasm and Facial Myokymia Associated with Hemifacial Atrophy and Localized Morphea with Botulinum Neurotoxin and Immunotherapy
Background: Hemimasticatory spasm (HMS) is a rare paroxysmal movement disorder characterized by the dysfunction of the motor branch of the trigeminal nerve affecting the muscles of mastication and culminating in a painful spasm of the masticatory muscles. HMS is associated with progressive hemifacial hemiatrophy (Parry-Romberg syndrome), and localized scleroderma (morphea). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: F. Mustafa, K. Sai Krishna, D.M. Radhakrishnan, B.K. Khaitan, D. Garg, A. Agarwal, A.K. Pandit, A.K. Srivastava Source Type: research
Noninvasively Deciphering the Immunosuppressive Tumor Microenvironment Using Galectin-1 PET to Inform Immunotherapy Responses
Conclusion: Our study underscores the potential of Gal-1–targeted PET imaging as a valuable strategy for early-stage monitoring of tumor responses to ICB therapy. Additionally, Gal-1 inhibition effectively counteracts the immunosuppressive TME, resulting in enhanced immunotherapy efficacy. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Liu, N., Yang, X., Gao, C., Wang, J., Zeng, Y., Zhang, L., Yin, Q., Zhang, T., Zhou, H., Li, K., Du, J., Zhou, S., Zhao, X., Zhu, H., Yang, Z., Liu, Z. Tags: FEATURED BASIC SCIENCE ARTICLE Source Type: research
Cancers, Vol. 16, Pages 1759: Kinetics of IFN & gamma;-Induced Cytokines and Development of Immune-Related Adverse Events in Patients Receiving PD-(L)1 Inhibitors
In conclusion, our study elucidates the dynamic changes in cytokine profiles associated with serious irAE development during treatment with PD-(L)1 inhibitors. The study’s findings offer valuable insights into the intricate IFN-induced immune responses associated with irAEs and propose potential predictive markers for their severity. (Source: Cancers)
Source: Cancers - May 1, 2024 Category: Cancer & Oncology Authors: Leticia Alserawan Maria Mulet Ge òrgia Anguera Mariona Riudavets Carlos Zamora Rub én Osuna-Gómez Jorgina Serra-L ópez Andr és Barba Joaquín Ivana Sullivan Margarita Majem Silvia Vidal Tags: Article Source Type: research
Multi-cohort comprehensive analysis unveiling the clinical value and therapeutic effect of < em > GNAL < /em > in glioma
In this study, we aimed to investigate the role and relationship between OSPRGs and glioma. Univariate and multivariate Cox regression analyses were performed to assess the relationship between OSPRGs and the overall survival of glioma based on public cohorts, and the target gene (G Protein Subunit Alpha L, GNAL) was screened. The association of GNAL expression with clinicopathological characteristics, gene mutation landscape, tumor immune microenvironment (TIME), deoxyribonucleic acid (DNA) methylation, and naris-occlusion controlled genes (NOCGs) was performed. Immunohistochemistry was used to evaluate GNAL level in glio...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Zhen Liu Liangwang Yang Zhengxing Xie Hui Yu Tianyi Gu Daoming Shi Ning Cai Shenghua Zhuo Source Type: research
Association of opioid use with survival in patients with cancer treated with immune checkpoint inhibitors: it is time for evidence-based behaviors
Oncologist. 2024 Apr 30:oyae081. doi: 10.1093/oncolo/oyae081. Online ahead of print.ABSTRACTCancer is a leading cause of morbidity and mortality worldwide, with pain experienced by most patients undergoing cancer treatment. Opioids are the recommended treatment for cancer pain management, but recent studies suggest a negative association between opioid use and survival rates among patients undergoing immunotherapy. However, conclusions cannot be drawn regarding causality from these observational data. Immunotherapy, which boosts the body's immune system to fight cancer cells, has emerged as a promising treatment option for...
Source: The Oncologist - April 30, 2024 Category: Cancer & Oncology Authors: Raffaele Giusti Giampiero Porzio Marco Maltoni Marco Filetti Arturo Cuomo Elena Bandieri Dario Trapani Eduardo Bruera Source Type: research
Multi-cohort comprehensive analysis unveiling the clinical value and therapeutic effect of < em > GNAL < /em > in glioma
In this study, we aimed to investigate the role and relationship between OSPRGs and glioma. Univariate and multivariate Cox regression analyses were performed to assess the relationship between OSPRGs and the overall survival of glioma based on public cohorts, and the target gene (G Protein Subunit Alpha L, GNAL) was screened. The association of GNAL expression with clinicopathological characteristics, gene mutation landscape, tumor immune microenvironment (TIME), deoxyribonucleic acid (DNA) methylation, and naris-occlusion controlled genes (NOCGs) was performed. Immunohistochemistry was used to evaluate GNAL level in glio...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Zhen Liu Liangwang Yang Zhengxing Xie Hui Yu Tianyi Gu Daoming Shi Ning Cai Shenghua Zhuo Source Type: research
Association of opioid use with survival in patients with cancer treated with immune checkpoint inhibitors: it is time for evidence-based behaviors
Oncologist. 2024 Apr 30:oyae081. doi: 10.1093/oncolo/oyae081. Online ahead of print.ABSTRACTCancer is a leading cause of morbidity and mortality worldwide, with pain experienced by most patients undergoing cancer treatment. Opioids are the recommended treatment for cancer pain management, but recent studies suggest a negative association between opioid use and survival rates among patients undergoing immunotherapy. However, conclusions cannot be drawn regarding causality from these observational data. Immunotherapy, which boosts the body's immune system to fight cancer cells, has emerged as a promising treatment option for...
Source: The Oncologist - April 30, 2024 Category: Cancer & Oncology Authors: Raffaele Giusti Giampiero Porzio Marco Maltoni Marco Filetti Arturo Cuomo Elena Bandieri Dario Trapani Eduardo Bruera Source Type: research
