High tumor infiltrating lymphocytes are significantly associated with pathological complete response in triple negative breast cancer treated with neoadjuvant KEYNOTE-522 chemoimmunotherapy
ConclusionOur real-world data demonstrates high TIL is significantly associated with pCR rate in the K522 regimen and may potentially serve as a biomarker to select optimal treatment. The pCR rate of 48.4% in our study is lower than that reported in K522, potentially due to the smaller size of our study; however, this may also indicate differences between real-world data and clinical trial results. Larger studies are warranted to further investigate the role of immune cells in TNBC response to K522 and other treatment regimens. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - May 1, 2024 Category: Cancer & Oncology Source Type: research
Modulating extracellular matrix stiffness: a strategic approach to boost cancer immunotherapy
Cell Death & Disease, Published online: 01 May 2024; doi:10.1038/s41419-024-06697-4Modulating extracellular matrix stiffness: a strategic approach to boost cancer immunotherapy (Source: Cell death and disease)
Source: Cell death and disease - May 1, 2024 Category: Internal Medicine Authors: Zizhao Mai Yunfan Lin Pei Lin Xinyuan Zhao Li Cui Source Type: research
Treatment of Hemimasticatory Spasm and Facial Myokymia Associated with Hemifacial Atrophy and Localized Morphea with Botulinum Neurotoxin and Immunotherapy
Background: Hemimasticatory spasm (HMS) is a rare paroxysmal movement disorder characterized by the dysfunction of the motor branch of the trigeminal nerve affecting the muscles of mastication and culminating in a painful spasm of the masticatory muscles. HMS is associated with progressive hemifacial hemiatrophy (Parry-Romberg syndrome), and localized scleroderma (morphea). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: F. Mustafa, K. Sai Krishna, D.M. Radhakrishnan, B.K. Khaitan, D. Garg, A. Agarwal, A.K. Pandit, A.K. Srivastava Source Type: research
Noninvasively Deciphering the Immunosuppressive Tumor Microenvironment Using Galectin-1 PET to Inform Immunotherapy Responses
Conclusion: Our study underscores the potential of Gal-1–targeted PET imaging as a valuable strategy for early-stage monitoring of tumor responses to ICB therapy. Additionally, Gal-1 inhibition effectively counteracts the immunosuppressive TME, resulting in enhanced immunotherapy efficacy. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Liu, N., Yang, X., Gao, C., Wang, J., Zeng, Y., Zhang, L., Yin, Q., Zhang, T., Zhou, H., Li, K., Du, J., Zhou, S., Zhao, X., Zhu, H., Yang, Z., Liu, Z. Tags: FEATURED BASIC SCIENCE ARTICLE Source Type: research
Cancers, Vol. 16, Pages 1759: Kinetics of IFN & gamma;-Induced Cytokines and Development of Immune-Related Adverse Events in Patients Receiving PD-(L)1 Inhibitors
In conclusion, our study elucidates the dynamic changes in cytokine profiles associated with serious irAE development during treatment with PD-(L)1 inhibitors. The study’s findings offer valuable insights into the intricate IFN-induced immune responses associated with irAEs and propose potential predictive markers for their severity. (Source: Cancers)
Source: Cancers - May 1, 2024 Category: Cancer & Oncology Authors: Leticia Alserawan Maria Mulet Ge òrgia Anguera Mariona Riudavets Carlos Zamora Rub én Osuna-Gómez Jorgina Serra-L ópez Andr és Barba Joaquín Ivana Sullivan Margarita Majem Silvia Vidal Tags: Article Source Type: research
Multi-cohort comprehensive analysis unveiling the clinical value and therapeutic effect of < em > GNAL < /em > in glioma
In this study, we aimed to investigate the role and relationship between OSPRGs and glioma. Univariate and multivariate Cox regression analyses were performed to assess the relationship between OSPRGs and the overall survival of glioma based on public cohorts, and the target gene (G Protein Subunit Alpha L, GNAL) was screened. The association of GNAL expression with clinicopathological characteristics, gene mutation landscape, tumor immune microenvironment (TIME), deoxyribonucleic acid (DNA) methylation, and naris-occlusion controlled genes (NOCGs) was performed. Immunohistochemistry was used to evaluate GNAL level in glio...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Zhen Liu Liangwang Yang Zhengxing Xie Hui Yu Tianyi Gu Daoming Shi Ning Cai Shenghua Zhuo Source Type: research
Association of opioid use with survival in patients with cancer treated with immune checkpoint inhibitors: it is time for evidence-based behaviors
Oncologist. 2024 Apr 30:oyae081. doi: 10.1093/oncolo/oyae081. Online ahead of print.ABSTRACTCancer is a leading cause of morbidity and mortality worldwide, with pain experienced by most patients undergoing cancer treatment. Opioids are the recommended treatment for cancer pain management, but recent studies suggest a negative association between opioid use and survival rates among patients undergoing immunotherapy. However, conclusions cannot be drawn regarding causality from these observational data. Immunotherapy, which boosts the body's immune system to fight cancer cells, has emerged as a promising treatment option for...
Source: The Oncologist - April 30, 2024 Category: Cancer & Oncology Authors: Raffaele Giusti Giampiero Porzio Marco Maltoni Marco Filetti Arturo Cuomo Elena Bandieri Dario Trapani Eduardo Bruera Source Type: research
Multi-cohort comprehensive analysis unveiling the clinical value and therapeutic effect of < em > GNAL < /em > in glioma
In this study, we aimed to investigate the role and relationship between OSPRGs and glioma. Univariate and multivariate Cox regression analyses were performed to assess the relationship between OSPRGs and the overall survival of glioma based on public cohorts, and the target gene (G Protein Subunit Alpha L, GNAL) was screened. The association of GNAL expression with clinicopathological characteristics, gene mutation landscape, tumor immune microenvironment (TIME), deoxyribonucleic acid (DNA) methylation, and naris-occlusion controlled genes (NOCGs) was performed. Immunohistochemistry was used to evaluate GNAL level in glio...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Zhen Liu Liangwang Yang Zhengxing Xie Hui Yu Tianyi Gu Daoming Shi Ning Cai Shenghua Zhuo Source Type: research
Association of opioid use with survival in patients with cancer treated with immune checkpoint inhibitors: it is time for evidence-based behaviors
Oncologist. 2024 Apr 30:oyae081. doi: 10.1093/oncolo/oyae081. Online ahead of print.ABSTRACTCancer is a leading cause of morbidity and mortality worldwide, with pain experienced by most patients undergoing cancer treatment. Opioids are the recommended treatment for cancer pain management, but recent studies suggest a negative association between opioid use and survival rates among patients undergoing immunotherapy. However, conclusions cannot be drawn regarding causality from these observational data. Immunotherapy, which boosts the body's immune system to fight cancer cells, has emerged as a promising treatment option for...
Source: The Oncologist - April 30, 2024 Category: Cancer & Oncology Authors: Raffaele Giusti Giampiero Porzio Marco Maltoni Marco Filetti Arturo Cuomo Elena Bandieri Dario Trapani Eduardo Bruera Source Type: research
A Meta-Analysis Investigating the Efficacy and Safety of Allergen-Specific Immunotherapy in the Management of Respiratory Allergies
Conclusion: The results of our meta-analysis suggest that specific immunotherapy, while associated with some adverse effects, effectively reduces the symptoms of asthma and rhinitis. Therefore, we recommend its use in the treatment of respiratory allergies.PMID:38687911 | DOI:10.1080/02770903.2024.2349604 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Xue Li Juju Shang Jian Liu Yong Zhu Source Type: research
Multiomics Analysis of Disulfidptosis Patterns and Integrated Machine Learning to Predict Immunotherapy Response in Lung Adenocarcinoma
CONCLUSION: Our research introduces an innovative prognostic risk model predicated upon disulfidptosis genes for patients afflicted with Lung Adenocarcinoma (LUAD). This model proficiently forecasts the survival rates and therapeutic outcomes for LUAD patients, thereby delineating the high-risk population with distinctive immune cell infiltration and a state of immunosuppression. Furthermore, NAPSA can inhibit the proliferation and invasion capabilities of LUAD cells, thereby identifying new molecules for clinical targeted therapy.PMID:38685772 | DOI:10.2174/0109298673313281240425050032 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Junzhi Liu Huimin Li Nannan Zhang Qiuping Dong Zheng Liang Source Type: research
Pharmacological inhibition of HPK1 synergizes with PD-L1 blockade to provoke antitumor immunity against tumors with low antigenicity
Biochem Biophys Res Commun. 2024 Apr 24;715:149995. doi: 10.1016/j.bbrc.2024.149995. Online ahead of print.ABSTRACTImmune checkpoint inhibitors have significantly transformed the landscape of cancer therapy. Nevertheless, while these inhibitors are highly effective for certain patient groups, many do not benefit due to primary or acquired resistance. Specifically, these treatments often lack sufficient therapeutic efficacy against cancers with low antigenicity. Thus, the development of an effective strategy to overcome cancers with low antigenicity is imperative for advancing next-generation cancer immunotherapy. Here, we ...
Source: Biochemical and Biophysical Research communications - April 30, 2024 Category: Biochemistry Authors: Genzui Setsu Megumi Goto Kentaro Ito Tomoe Taira Masaya Miyamoto Tomohiro Watanabe Saito Higuchi Source Type: research
Multi-omics analysis reveals the association between specific solute carrier proteins gene expression patterns and the immune suppressive microenvironment in glioma
J Cell Mol Med. 2024 May;28(9):e18339. doi: 10.1111/jcmm.18339.ABSTRACTGlioma is the most prevalent malignant brain tumour. Currently, reshaping its tumour microenvironment has emerged as an appealing strategy to enhance therapeutic efficacy. As the largest group of transmembrane transport proteins, solute carrier proteins (SLCs) are responsible for the transmembrane transport of various metabolites and ions. They play a crucial role in regulating the metabolism and functions of malignant cells and immune cells within the tumour microenvironment, making them a promising target in cancer therapy. Through multidimensional da...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Wenjie Wu Cheng Jiang Wende Zhu Xiaobing Jiang Source Type: research
A potassium-chloride co-transporter with altered genome architecture functions as a suppressor in glioma
J Cell Mol Med. 2024 May;28(9):e18352. doi: 10.1111/jcmm.18352.ABSTRACTGliomas, the most lethal tumours in brain, have a poor prognosis despite accepting standard treatment. Limited benefits from current therapies can be attributed to genetic, epigenetic and microenvironmental cues that affect cell programming and drive tumour heterogeneity. Through the analysis of Hi-C data, we identified a potassium-chloride co-transporter SLC12A5 associated with disrupted topologically associating domain which was downregulated in tumour tissues. Multiple independent glioma cohorts were included to analyse the characterization of SLC12A...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Hongwei Liu Zhouyang Pan Xuelei Lin Long Chen Qi Yang Wei Zhang Luohuan Dai Yihao Zhang Wang Li Yinhua Chen Kang Peng Siyi Wanggou Feiyue Zeng Xuejun Li Source Type: research
Implications of intestinal microecology and immune function alterations for immunotherapy outcomes in advanced unresectable lung adenocarcinoma
CONCLUSION: The structuring of gut flora plays a pivotal role in augmenting the efficacy of anti-tumor immunotherapy, underscoring the interplay between intestinal microecology and immune response in cancer treatment outcomes.PMID:38685799 | PMC:PMC11058370 | DOI:10.1111/crj.13762 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Shuang He Jin Tian Jianhua Zang Lin Long Peng Liu Yexi Zhang Jun Xiao Source Type: research
