Cancers, Vol. 16, Pages 1737: High Serum Levels of CCL20 Are Associated with Recurrence and Unfavorable Overall Survival in Advanced Melanoma Patients Receiving Immunotherapy
Conclusions: CCL20 may represent a novel blood-based biomarker for the prediction of resistance to immunotherapy that can be used in combination with established strong clinical predictors (e.g., ECOG performance score) and laboratory markers (e.g., S100) in advanced melanoma patients. Future prospective randomized trials are needed to establish CCL20 as a liquid biopsy-based biomarker in advanced melanoma. (Source: Cancers)
Source: Cancers - April 29, 2024 Category: Cancer & Oncology Authors: Julian K ött Inka Lilott Hoehne Isabel Heidrich Noah Zimmermann Kim-Lea Reese Tim Zell Glenn Geidel Alessandra R ünger Stefan W. Schneider Klaus Pantel Daniel J. Smit Christoffer Gebhardt Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1735: Management of High-Risk Neuroblastoma with Soft-Tissue-Only Disease in the Era of Anti-GD2 Immunotherapy
In conclusion, adding treatment with anti-GD2 mAbs at the stage of MRD helps prevent relapse that unequivocally portends poor survival. (Source: Cancers)
Source: Cancers - April 29, 2024 Category: Cancer & Oncology Authors: Maite Gorostegui Juan Pablo Mu ñoz Sara Perez-Jaume Margarida Simao-Rafael Cristina Larrosa Moira Garraus Noelia Salvador Cinzia Lavarino Lucas Krauel Salvador Ma ñe Alicia Casta ñeda Jaume Mora Tags: Article Source Type: research
Viruses, Vol. 16, Pages 707: The Adaptive Immune Response in Hepatitis B Virus-Associated Hepatocellular Carcinoma Is Characterized by Dysfunctional and Exhausted HBV-Specific T Cells
na Weis
This systematic review investigates the immunosuppressive environment in HBV-associated hepatocellular carcinoma (HCC), characterized by dysfunctional and exhausted HBV-specific T cells alongside an increased infiltration of HBV-specific CD4+ T cells, particularly regulatory T cells (Tregs). Heightened expression of checkpoint inhibitors, notably PD-1, is linked with disease progression and recurrence, indicating its potential as both a prognostic indicator and a target for immunotherapy. Nevertheless, using PD-1 inhibitors has shown limited effectiveness. In a future perspective, understanding the intricate in...
Source: Viruses - April 29, 2024 Category: Virology Authors: Malene Broholm Anne-Sofie Mathiasen Ása Didriksen Apol Nina Weis Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1728: FDG-PET in Chimeric Antigen Receptor T-Cell (CAR T-Cell) Therapy Toxicity: A Systematic Review
This study offers a pioneering exploration of this promising field, with the goal of encouraging further and more focused research in upcoming clinical trials. (Source: Cancers)
Source: Cancers - April 29, 2024 Category: Cancer & Oncology Authors: Akram Al-Ibraheem Ahmed Saad Abdlkadir Egesta Lopci Sudqi Allouzi Diana Paez Maryam Alkuwari Mohammad Makoseh Fuad Novruzov Sharjeel Usmani Kamal Al-Rabi Asem Mansour Tags: Systematic Review Source Type: research
Tumor cells inhibit the activation of ILC2s through up-regulating PD-1 expression
Immunopharmacol Immunotoxicol. 2024 Apr 28:1-10. doi: 10.1080/08923973.2024.2347315. Online ahead of print.ABSTRACTUp-regulating programmed cell death ligand-1(PD-L1) expressed on tumor cells and tumor-infiltrating myeloid cells interacting with up-regulated programmed cell death-1 (PD-1) expressed on tumor-infiltrating lymphoid cells greatly hinder their tumor-inhibiting effect. It is necessary to explore the deep mechanism of this negative effect, so as to find the potential methods to improve the immunotherapy efficiency. Here, we found that the PD-1 expression in lung cancer-infiltrating type II innate lymphoid cells (...
Source: Immunopharmacology and Immunotoxicology - April 28, 2024 Category: Allergy & Immunology Authors: Chaoyun Yin Yani Pa Guangyu Li Qiang Chen Xizu Wang Xijun He Huangao Zhou Source Type: research
Characterization of the prognostic, diagnostic, and immunological roles of DSCC1 and its genomic alteration and instability in human cancers
In this study, we obtained data on physiological conditions, transcriptional expression, survival prognosis, genomic alteration, genomic instability, enriched pathways, immune infiltration, and immunotherapy from The Cancer Genome Atlas, The Genotype-Tissue Expression, cBioPortal, and other publicly available databases to systematically characterize the oncogenic and immunological roles of DSCC1 in 33 different cancers. We found that DSCC1 expression was upregulated at both mRNA and protein levels in various cancers. Additionally, DSCC1 expression was associated with higher tumor stage and grade in specific cancers. DSCC1 ...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Hailong Liu Zhiwei Cui Rongli Wang Lijun Wang Lihui Wang Feiyan Cheng Rumeng Pan Xinyuan Yang Source Type: research
MAL, a potential immunotherapy target, is associated with poor prognosis in cancer patients
In conclusion, the pan-cancer study indicates that MAL with excellent prognostic value is a potential immunotherapy target in multiple cancers.PMID:38678596 | DOI:10.14715/cmb/2024.70.4.39 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Ruinian Zheng Biao Yao Yongkang Ye Ruijuan Luo Zhiming Wu Xiarong Hu Yinjiao Yuan Xuebing Pan Caixiang Liu Linxuan Huang Yongmei Luo Dan Yang NiYa Shang Yamin Tian Jun Jia Source Type: research
Mechanistic role of pyroptosis in tumor microenvironment and tumor immunotherapy
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):260-267. doi: 10.14715/cmb/2024.70.4.41.ABSTRACTIn recent decades, extraordinary attention has been devoted to cell death pathways principally because of multifaceted regulatory roles in normal developmental and pathophysiological processes. The removal of functionally defective, infected or potentially malignant cells is regulated by programmed cell death (PCD) cascades. Pyroptotic cell death is a highly complicated pro-inflammatory form of cell death. Pyroptosis is characterized by the formation of pores in the plasma membrane by oligomerization of the N-terminal fragment...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Rukset Attar Muhammad Zahid Qureshi Uteuliyev Yerzhan Sabitaliyevich Ishmuratova Margarita Yulaevna Mirna Azalea Romero Source Type: research
Tumor cells inhibit the activation of ILC2s through up-regulating PD-1 expression
Immunopharmacol Immunotoxicol. 2024 Apr 28:1-10. doi: 10.1080/08923973.2024.2347315. Online ahead of print.ABSTRACTUp-regulating programmed cell death ligand-1(PD-L1) expressed on tumor cells and tumor-infiltrating myeloid cells interacting with up-regulated programmed cell death-1 (PD-1) expressed on tumor-infiltrating lymphoid cells greatly hinder their tumor-inhibiting effect. It is necessary to explore the deep mechanism of this negative effect, so as to find the potential methods to improve the immunotherapy efficiency. Here, we found that the PD-1 expression in lung cancer-infiltrating type II innate lymphoid cells (...
Source: Immunopharmacology and Immunotoxicology - April 28, 2024 Category: Allergy & Immunology Authors: Chaoyun Yin Yani Pa Guangyu Li Qiang Chen Xizu Wang Xijun He Huangao Zhou Source Type: research
Mechanistic role of pyroptosis in tumor microenvironment and tumor immunotherapy
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):260-267. doi: 10.14715/cmb/2024.70.4.41.ABSTRACTIn recent decades, extraordinary attention has been devoted to cell death pathways principally because of multifaceted regulatory roles in normal developmental and pathophysiological processes. The removal of functionally defective, infected or potentially malignant cells is regulated by programmed cell death (PCD) cascades. Pyroptotic cell death is a highly complicated pro-inflammatory form of cell death. Pyroptosis is characterized by the formation of pores in the plasma membrane by oligomerization of the N-terminal fragment...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Rukset Attar Muhammad Zahid Qureshi Uteuliyev Yerzhan Sabitaliyevich Ishmuratova Margarita Yulaevna Mirna Azalea Romero Source Type: research
MAL, a potential immunotherapy target, is associated with poor prognosis in cancer patients
In conclusion, the pan-cancer study indicates that MAL with excellent prognostic value is a potential immunotherapy target in multiple cancers.PMID:38678596 | DOI:10.14715/cmb/2024.70.4.39 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Ruinian Zheng Biao Yao Yongkang Ye Ruijuan Luo Zhiming Wu Xiarong Hu Yinjiao Yuan Xuebing Pan Caixiang Liu Linxuan Huang Yongmei Luo Dan Yang NiYa Shang Yamin Tian Jun Jia Source Type: research
Characterization of the prognostic, diagnostic, and immunological roles of DSCC1 and its genomic alteration and instability in human cancers
In this study, we obtained data on physiological conditions, transcriptional expression, survival prognosis, genomic alteration, genomic instability, enriched pathways, immune infiltration, and immunotherapy from The Cancer Genome Atlas, The Genotype-Tissue Expression, cBioPortal, and other publicly available databases to systematically characterize the oncogenic and immunological roles of DSCC1 in 33 different cancers. We found that DSCC1 expression was upregulated at both mRNA and protein levels in various cancers. Additionally, DSCC1 expression was associated with higher tumor stage and grade in specific cancers. DSCC1 ...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Hailong Liu Zhiwei Cui Rongli Wang Lijun Wang Lihui Wang Feiyan Cheng Rumeng Pan Xinyuan Yang Source Type: research
Tumor cells inhibit the activation of ILC2s through up-regulating PD-1 expression
Immunopharmacol Immunotoxicol. 2024 Apr 28:1-10. doi: 10.1080/08923973.2024.2347315. Online ahead of print.ABSTRACTUp-regulating programmed cell death ligand-1(PD-L1) expressed on tumor cells and tumor-infiltrating myeloid cells interacting with up-regulated programmed cell death-1 (PD-1) expressed on tumor-infiltrating lymphoid cells greatly hinder their tumor-inhibiting effect. It is necessary to explore the deep mechanism of this negative effect, so as to find the potential methods to improve the immunotherapy efficiency. Here, we found that the PD-1 expression in lung cancer-infiltrating type II innate lymphoid cells (...
Source: Immunopharmacology and Immunotoxicology - April 28, 2024 Category: Allergy & Immunology Authors: Chaoyun Yin Yani Pa Guangyu Li Qiang Chen Xizu Wang Xijun He Huangao Zhou Source Type: research
Characterization of the prognostic, diagnostic, and immunological roles of DSCC1 and its genomic alteration and instability in human cancers
In this study, we obtained data on physiological conditions, transcriptional expression, survival prognosis, genomic alteration, genomic instability, enriched pathways, immune infiltration, and immunotherapy from The Cancer Genome Atlas, The Genotype-Tissue Expression, cBioPortal, and other publicly available databases to systematically characterize the oncogenic and immunological roles of DSCC1 in 33 different cancers. We found that DSCC1 expression was upregulated at both mRNA and protein levels in various cancers. Additionally, DSCC1 expression was associated with higher tumor stage and grade in specific cancers. DSCC1 ...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Hailong Liu Zhiwei Cui Rongli Wang Lijun Wang Lihui Wang Feiyan Cheng Rumeng Pan Xinyuan Yang Source Type: research
MAL, a potential immunotherapy target, is associated with poor prognosis in cancer patients
In conclusion, the pan-cancer study indicates that MAL with excellent prognostic value is a potential immunotherapy target in multiple cancers.PMID:38678596 | DOI:10.14715/cmb/2024.70.4.39 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Ruinian Zheng Biao Yao Yongkang Ye Ruijuan Luo Zhiming Wu Xiarong Hu Yinjiao Yuan Xuebing Pan Caixiang Liu Linxuan Huang Yongmei Luo Dan Yang NiYa Shang Yamin Tian Jun Jia Source Type: research
