The Role of Immune Aging in Neurodegenerative Conditions
The research community has come to see chronic inflammation and other age-related immune system dysfunctions as an important aspect of neurodegenerative conditions. Inflammation in the short term is necessary for defense against pathogens and regeneration following injury. Unresolved, constant inflammation is harmful to tissue structure and function, however, changing cell behavior for the worse. In brain tissue, the effects of inflammatory signaling on the behavior of innate immune cells called microglia appears particularly important. Neurogenerative conditions are characterized by activated microglia. These microglia ar...
Source: Fight Aging! - April 23, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Enabling Microglia to Better Clear Amyloid by Interfering in the LILRB4-APOE Interaction
Researchers here describe a mechanism that reduces the ability of microglia to ingest and clear misfolded amyloid-β, the protein aggregates associated with Alzheimer's disease. Interestingly, this involves APOE, and thus might be affected by the different APOE variants connected to Alzheimer's disease risk. The researchers demonstrate that interfering in the interaction between APOE and the LILRB4 receptor present on microglia can restore microglia-mediated clearance of amyloid-β.
Toxic clumps of brain proteins are features of many neurodegenerative conditions, including Alzheimer's disease (AD), Parkinson's dis...
Source: Fight Aging! - April 11, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 1st 2024
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression can promote increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes.
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A Skeptical View of the Role of Nuclear DNA Damage in Aging
https://www.fightaging.org/archives/2024/03/a-skeptical-view-of-the-role-of-nuclear-dna-damage-in-aging/
It is evident and settled that stochastic nuclear DNA damag...
Source: Fight Aging! - March 31, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Long and Tortured History of Alpha-Synuclein and Parkinson ’s Disease
This study tracks the decades-long journey to harness alpha-synuclein as a treatment for Parkinson’s disease. Steven Zecola an activist who tracks Parkinson’s research and was on THCB last month discussing it, offers three key changes needed to overcome the underlying challenges.
A Quick Start for Alpha-Synuclein R&D
In the mid-1990’s, Parkinson’s patient advocacy groups had become impatient by the absence of any major therapeutic advances in the 25 years since L-dopa had been approved for Parkinson’s disease (PD).
The Director of National Institute of Neurological Disorders and Stroke (NINDS) se...
Source: The Health Care Blog - March 29, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Medical Practice Parkinson's Disease Steven Zecola Source Type: blogs
Predicting the Order of Arrival of the First Rejuvenation Therapies
It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven in principle but not concretely. The world progresses but my biases remain much the same: the first rejuvenation therapies to work well enough to merit the name will be based on the SENS vision, that aging is at root caused by a few classes of accumulated cell and tissue damage, and biotechnologies that either repa...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
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Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Thoughts on What is Revealed in the Trial Data for Amyloid- β Clearance
There are now several immunotherapies capable of clearing amyloid-β aggregates from the aging brain, and a sizable amount of clinical trial data to look through. Sadly, this approach doesn't much help patients in the later stages of Alzheimer's disease, but the evidence to date suggests that it may be useful in prevention if the clearance is conducted early enough. Amyloid-β aggregation causes mild cognitive impairment in and of itself, but really just sets the stage for a set of different processes, inflammation and tau aggregation, that drive the late stage of Alzheimer's disease. At that point, clearing amyloid-β mak...
Source: Fight Aging! - March 22, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Intralymphatic immunotherapy and the future of allergy care [PODCAST]
Subscribe to The Podcast by KevinMD. Watch on YouTube. Catch up on old episodes! Join Kara Wada, an adult and pediatric allergy and immunology physician. We’ll delve into the world of allergy treatments, exploring the challenges faced by millions dealing with seasonal and year-round allergies. From traditional methods like medications and avoidance to revolutionary advancements
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Intralymphatic immunotherapy and the future of allergy care [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 20, 2024 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Allergies & Immunology Source Type: blogs
Fight Aging! Newsletter, March 11th 2024
In conclusion, this Mendelian randomization study found that Streptococcus was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process.
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Considering the Mechanisms of Vascular Calcification
https://www.fightaging.org/archives/2024/03/considering-the-mechanisms-of-vascular-calcification/
Harmful calcification of structures in the cardiovascular system proceeds alongside the development of the fatty lesions of atherosclerosis. Both disease processes are accelerated by chronic inflammation, but d...
Source: Fight Aging! - March 10, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Blood Tests for Alzheimer's Disease Continue to Look Promising
In recent years, data has shown correlations between specific blood biomarkers and Alzheimer's disease pathology in the brain, such as the burden of misfolded, aggregated amyloid-β. This has led to the development of a variety of blood tests for Alzheimer's disease, intended to replace the presently onerous testing that requires either expensive imaging or invasive analysis of cerebrospinal fluid. Alzheimer's disease develops slowly over time, a long period of raised amyloid-β levels in the brain setting the stage for later dysfunction. Early testing for the risk of later Alzheimer's disease enabled attempts to slow or e...
Source: Fight Aging! - March 6, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 26th 2024
In conclusion, mTORC1 signaling contributes to the ISC fate decision, enabling regional control of intestinal cell differentiation in response to nutrition.
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Reviewing the Development of Senotherapeutics to Treat Aging
https://www.fightaging.org/archives/2024/02/reviewing-the-development-of-senotherapeutics-to-treat-aging/
Senescent cells accumulate with age and contribute meaningfully to chronic inflammation and degenerative aging. Destroying these cells produces rapid and sizable reversal of age-related diseases in mice, demonstrating that the presence of senescence cells ...
Source: Fight Aging! - February 25, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the Development of Senotherapeutics to Treat Aging
Senescent cells accumulate with age and contribute meaningfully to chronic inflammation and degenerative aging. Destroying these cells produces rapid and sizable reversal of age-related diseases in mice, demonstrating that the presence of senescence cells acts to maintain a more dysfunctional, inflamed metabolism. This is well known by now, and numerous biotech companies in the first wave of development of senolytic treatments to selectively destroy senescent cells are in varying stages of preclinical and clinical development. Meanwhile, the off-label use of dasatinib and quercetin, a low-cost senolytic therapy that is nei...
Source: Fight Aging! - February 19, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 5th 2024
In conclusion, the Immunity and Redox Clocks allow BA quantification in mice and both the ImmunolAge and RedoxAge in mice relate to lifespan.
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Senolytic CAR T Cell Therapy Improves Health in Aged Mice
https://www.fightaging.org/archives/2024/01/senolytic-car-t-cell-therapy-improves-health-in-aged-mice/
To the degree that senescent cells in a tissue exhibit distinctive surface features, one can deploy technologies such as chimeric antigen receptor T cells to selectively destroy them. T cells will destroy whatever cell binds to the chimeric antigen receptor they are equipped w...
Source: Fight Aging! - February 4, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Amyloid- β Biochemistry as a Cause of Blood-Brain Barrier Leakage in Alzheimer's Disease
Alzheimer's disease is a complex degenerative failure of a complex system, the brain. This complexity is illustrated by the continuing debate over which of the many identified mechanisms are the primary cause. Is it amyloid-β aggregation, or some aspect of the halo of biochemistry associated with that aggregation, or is it chronic inflammation, or cellular senescence in supporting cells of the brain, or vascular dysfunction and leakage of the blood-brain barrier, or neurofibrillary tangles, or the presence of persistent viruses. All of these mechanisms interact with one another, and the direction of causation between any ...
Source: Fight Aging! - January 30, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Intralymphatic immunotherapy: a breakthrough approach for allergies
Are you or a loved one constantly battling the frustrating symptoms of seasonal or year-round allergies? You are not alone; millions around the globe are affected by sneezing, itchy, watery red eyes, stuffy, runny noses, and headaches. Avoidance of triggers and medications may provide temporary relief, but for those seeking a longer-lasting or more natural
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Intralymphatic immunotherapy: a breakthrough approach for allergies originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 28, 2024 Category: General Medicine Authors: Amber Patterson, MD &
