Efficacy and Safety of Neoadjuvant Subcutaneous Envafolimab in dMMR/MSI-H Locally Advanced Colon Cancer
ConclusionsEnvafolimab yielded promising surgical outcomes and safety in dMMR/MSI-H locally advanced colon cancer, representing a promising treatment modality for this population. (Source: Targeted Oncology)
Source: Targeted Oncology - April 30, 2024 Category: Cancer & Oncology Source Type: research
Biomimetic nanodrug blocks CD73 to inhibit adenosine and boosts antitumor immune response synergically with photothermal stimulation
Combination of tumor immunotherapy with photothermal therapy (PTT) is a feasible tactic to overcome the drawback of immunotherapy such as poor immune response. Via triggering the immunogenic cells death (ICD), PT... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 30, 2024 Category: Nanotechnology Authors: Tan Li, Xingyu Zhang, Chengyu Shi, Qiao Liu and Yuetao Zhao Tags: Research Source Type: research
The association of ROS1 mutation with cancer immunity and its impact on the efficacy of pan-cancer immunotherapy
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 30, 2024 Category: Research Authors: Yingying Li, Hong Zhao, Jinyuan Huang, Huimeng Yan and Bin Zhao Tags: Letter to the Editor Source Type: research
Leveraging radiomics and machine learning to differentiate radiation necrosis from recurrence in patients with brain metastases
ConclusionsRadiomics with ML may assist the diagnostic ability of distinguishing RN from tumor recurrence after SRS. Further work is needed to validate this in a larger multi-institutional cohort and prospectively evaluate it ’s utility in patient care. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 30, 2024 Category: Cancer & Oncology Source Type: research
What is the future of immune checkpoints inhibitors for metastatic triple negative breast cancers?
Immunotherapy, Ahead of Print. (Source: Immunotherapy)
Source: Immunotherapy - April 30, 2024 Category: Allergy & Immunology Authors: Ramon Andrade de Mello K átia Roque Perez Puteri Abdul Haris Source Type: research
Correction to: 3D bioprinted tumor model: a prompt and convenient platform for overcoming immunotherapy resistance by recapitulating the tumor microenvironment
(Source: Cellular Oncology)
Source: Cellular Oncology - April 30, 2024 Category: Cancer & Oncology Source Type: research
Finding your CAR: The road ahead for engineered T-cells
Adoptive cellular therapy using chimeric antigen receptors (CAR) has transformed immunotherapy by engineering T cells to target specific antigens on tumor cells. As the field continues to advance, pathology laboratories will play increasingly essential roles in the complicated multi-step process of CAR-T therapy. These include the detection of targetable tumor antigens by flow cytometry or immunohistochemistry at the time of disease diagnosis and the isolation and infusion of CAR-T cells. Additional roles include (1) detecting antigen loss or heterogeneity that renders resistance to CAR-T as well as identifying alternative...
Source: American Journal of Pathology - April 30, 2024 Category: Pathology Authors: Po-Han Chen, Rianna Raghunandan, Jon S. Morrow, Samuel G. Katz Tags: Review Source Type: research
Overexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer
ConclusionsKCNK1 was significantly overexpressed in BC. A complex and sophisticated three-dimensional spatial transcriptional regulatory network existed in the KCNK1 TSS and promoted the upregulated of KCNK1 expression. The high expression of KCNK1 might be involved in the cell cycle, cellular metabolism, and tumour microenvironment through the regulation of potassium channels, and ultimately contributed to the deterioration of BC. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 30, 2024 Category: Research Source Type: research
Molecules, Vol. 29, Pages 2073: Therapeutic Applications of Nanomedicine: Recent Developments and Future Perspectives
Greish
The concept of nanomedicine has evolved significantly in recent decades, leveraging the unique phenomenon known as the enhanced permeability and retention (EPR) effect. This has facilitated major advancements in targeted drug delivery, imaging, and individualized therapy through the integration of nanotechnology principles into medicine. Numerous nanomedicines have been developed and applied for disease treatment, with a particular focus on cancer therapy. Recently, nanomedicine has been utilized in various advanced fields, including diagnosis, vaccines, immunotherapy, gene delivery, and tissue engineering. Mul...
Source: Molecules - April 30, 2024 Category: Chemistry Authors: Farah Rehan Mingjie Zhang Jun Fang Khaled Greish Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1747: Recent Progress in Treatment for HER2-Positive Advanced Gastric Cancer
aki
Human epidermal receptor (HER) 2-positive advanced gastric cancer is one of the major subtypes of gastric cancer, accounting for ~20% of all cases. Although combination therapy with trastuzumab and chemotherapy provides meaningful survival benefit, clinical trials targeting HER2 have failed to demonstrate clinical benefits in first- or subsequent-line treatment. Trastuzumab deruxtecan, an antibody–drug conjugate, has shown positive results even in later-line treatment and has become new standard treatment. In first-line therapy, combination therapy with pembrolizumab and trastuzumab plus chemotherapy ...
Source: Cancers - April 30, 2024 Category: Cancer & Oncology Authors: Takeshi Kawakami Kentaro Yamazaki Tags: Review Source Type: research
PD-L1 Immunohistochemical Expression in Endometrial Carcinoma: Egyptian Cross-Sectional Study
CONCLUSION: Our results concluded that PD-L1 expression was greater in both TCs and TILs in a subgroup of patients that have advanced age, LVSI and are TILs-rich, identifying them as potential candidates for anti-PD-1/PD-L1 immunotherapy.PMID:38680006 | DOI:10.31557/APJCP.2024.25.4.1441 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Maha Gamal Wahba Soliman Saba Soliman Maha Elsayed Salama Sarah Nasr Zeinab Abd El-Azeem Al Shereef Source Type: research
Evaluation of the Combined Effect of Caffeine and 5-Fluorouracil on Colorectal Cancer Cell Lines
In this study, initially HCT116 and HEK293 cell lines were cultured as cancer and normal cells, respectively. These cell lines were then evaluated for cytotoxicity, induction of apoptosis, and rate of cell migration. All data were analyzed by statistical methods.RESULTS: The results indicated that a combination of caffeine and 5-FU augmented their cytotoxicity in HCT116 cells but reduced cytotoxicity in HEK293 cells. No reduction was observed in the migration of HCT116 cells that were treated with caffeine or a combination of caffeine and 5-FU. Also, it seems that caffeine reverses the apoptotic effect of 5-FU in HCT116 ce...
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Fatemeh Khavari Mohammad Taheri Hamed Manoochehri Pejman Molaei Fatemeh Nouri Source Type: research
PD-L1 Immunohistochemical Expression in Endometrial Carcinoma: Egyptian Cross-Sectional Study
CONCLUSION: Our results concluded that PD-L1 expression was greater in both TCs and TILs in a subgroup of patients that have advanced age, LVSI and are TILs-rich, identifying them as potential candidates for anti-PD-1/PD-L1 immunotherapy.PMID:38680006 | DOI:10.31557/APJCP.2024.25.4.1441 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Maha Gamal Wahba Soliman Saba Soliman Maha Elsayed Salama Sarah Nasr Zeinab Abd El-Azeem Al Shereef Source Type: research
Evaluation of the Combined Effect of Caffeine and 5-Fluorouracil on Colorectal Cancer Cell Lines
In this study, initially HCT116 and HEK293 cell lines were cultured as cancer and normal cells, respectively. These cell lines were then evaluated for cytotoxicity, induction of apoptosis, and rate of cell migration. All data were analyzed by statistical methods.RESULTS: The results indicated that a combination of caffeine and 5-FU augmented their cytotoxicity in HCT116 cells but reduced cytotoxicity in HEK293 cells. No reduction was observed in the migration of HCT116 cells that were treated with caffeine or a combination of caffeine and 5-FU. Also, it seems that caffeine reverses the apoptotic effect of 5-FU in HCT116 ce...
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Fatemeh Khavari Mohammad Taheri Hamed Manoochehri Pejman Molaei Fatemeh Nouri Source Type: research
Immune checkpoint inhibitor-associated gastritis: Patterns and management
World J Gastroenterol. 2024 Apr 14;30(14):1941-1948. doi: 10.3748/wjg.v30.i14.1941.ABSTRACTImmune checkpoint inhibitors (ICIs) are widely used due to their effectiveness in treating various tumors. Immune-related adverse events (irAEs) are defined as adverse effects resulting from ICI treatment. Gastrointestinal irAEs are a common type of irAEs characterized by intestinal side effects, such as diarrhea and colitis, which may lead to the cessation of ICIs. Although irAE gastritis is rarely reported, it may lead to serious complications such as gastrorrhagia. Furthermore, irAE gastritis is often difficult to identify early d...
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Jing Lin Zhong-Qiao Lin Shi-Cheng Zheng Yu Chen Source Type: research
