Immune checkpoint inhibitor-associated gastritis: Patterns and management
World J Gastroenterol. 2024 Apr 14;30(14):1941-1948. doi: 10.3748/wjg.v30.i14.1941.ABSTRACTImmune checkpoint inhibitors (ICIs) are widely used due to their effectiveness in treating various tumors. Immune-related adverse events (irAEs) are defined as adverse effects resulting from ICI treatment. Gastrointestinal irAEs are a common type of irAEs characterized by intestinal side effects, such as diarrhea and colitis, which may lead to the cessation of ICIs. Although irAE gastritis is rarely reported, it may lead to serious complications such as gastrorrhagia. Furthermore, irAE gastritis is often difficult to identify early d...
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Jing Lin Zhong-Qiao Lin Shi-Cheng Zheng Yu Chen Source Type: research
PD-L1 Immunohistochemical Expression in Endometrial Carcinoma: Egyptian Cross-Sectional Study
CONCLUSION: Our results concluded that PD-L1 expression was greater in both TCs and TILs in a subgroup of patients that have advanced age, LVSI and are TILs-rich, identifying them as potential candidates for anti-PD-1/PD-L1 immunotherapy.PMID:38680006 | DOI:10.31557/APJCP.2024.25.4.1441 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Maha Gamal Wahba Soliman Saba Soliman Maha Elsayed Salama Sarah Nasr Zeinab Abd El-Azeem Al Shereef Source Type: research
Evaluation of the Combined Effect of Caffeine and 5-Fluorouracil on Colorectal Cancer Cell Lines
In this study, initially HCT116 and HEK293 cell lines were cultured as cancer and normal cells, respectively. These cell lines were then evaluated for cytotoxicity, induction of apoptosis, and rate of cell migration. All data were analyzed by statistical methods.RESULTS: The results indicated that a combination of caffeine and 5-FU augmented their cytotoxicity in HCT116 cells but reduced cytotoxicity in HEK293 cells. No reduction was observed in the migration of HCT116 cells that were treated with caffeine or a combination of caffeine and 5-FU. Also, it seems that caffeine reverses the apoptotic effect of 5-FU in HCT116 ce...
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Fatemeh Khavari Mohammad Taheri Hamed Manoochehri Pejman Molaei Fatemeh Nouri Source Type: research
Targeted and immunotherapy for the management of advanced urothelial carcinoma of the bladder
CONCLUSION: Six targeted and immunotherapeutic agents have been approved for patients with advanced urothelial bladder cancer. They all have demonstrated activity in patients for whom disease has progressed during or after platinum-based therapy. Pembrolizumab, with and without enfortumab, has demonstrated first-line activity, and avelumab is a key maintenance therapy after first-line treatment. The results of additional clinical trials should provide evidence to establish the exact role in therapy of each agent in patients with advanced disease.PMID:38679913 | DOI:10.1093/ajhp/zxae090 (Source: American Journal of Health-S...
Source: American Journal of Health-System Pharmacy : AJHP - April 29, 2024 Category: Drugs & Pharmacology Authors: Robert J Cersosimo Source Type: research
Insights into metastatic roadmap of head and neck cancer squamous cell carcinoma based on clinical, histopathological and molecular profiles
Mol Biol Rep. 2024 Apr 29;51(1):597. doi: 10.1007/s11033-024-09476-8.ABSTRACTThe incidence of head and neck cancer (HNC), constituting approximately one in ten cancer cases worldwide, affects approximately 644,000 individuals annually. Managing this complex disease involves various treatment modalities such as systemic therapy, radiation, and surgery, particularly for patients with locally advanced disease. HNC treatment necessitates a multidisciplinary approach due to alterations in patients' genomes affecting their functionality. Predominantly, squamous cell carcinomas (SCCs), the majority of HNCs, arise from the upper a...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Nicholas S Mastronikolis Alexander Delides Efthymios Kyrodimos Zoi Piperigkou Despoina Spyropoulou Evangelos Giotakis Evangelos Tsiambas Nikos K Karamanos Source Type: research
Staging and systemic treatment of ocular and periocular metastases
Ophthalmologie. 2024 Apr 29. doi: 10.1007/s00347-024-02034-4. Online ahead of print.ABSTRACTMetastases of malignant diseases are the most frequent tumors diagnosed in the human eye. They occur in approximately 5-10% of patients with solid tumors during the course of the disease. Their frequency is particularly high in patients with breast and lung cancer. Many highly sensitive periorbital tissues can be affected by the localization of the metastatic lesions and pose a number of clinical challenges. The main goal of the therapy of ocular metastases consists of the control of tumor growth (including the control of other poss...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Daniela D örfel Neele Babst Ludwig Maximillian Heindl Vinodh Kakkassery Martin R M üller Source Type: research
Use of quantitative bias analysis to evaluate single-arm trials with real-world data external controls
CONCLUSION: These findings suggest that QBA can provide an intuitive framework for bias analysis, providing a key means of challenging assumptions about the evidence. However, the accuracy of bias analysis is itself dependent on correct specification of the bias model and bias factors. Ultimately, study design should reduce bias, but QBA allows us to evaluate the impact of unavoidable bias to assess the quality of the evidence.PMID:38680093 | DOI:10.1002/pds.5796 (Source: Cancer Control)
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Christen Gray Eleanor Ralphs Matthew P Fox Timothy L Lash Geoffrey Liu Tzuyung Doug Kou Donna R Rivera Jaclyn Bosco Kim Van Naarden Braun Fiona Grimson Deborah Layton Source Type: research
Checkpoint inhibitor immunotherapy induced inflammatory arthritis secondary to Nivolumab and Ipilimumab: a pediatric first
Immune checkpoint inhibitors (ICIs) have expanded the arsenal of cancer therapeutics over the last decade but are associated with a spectrum of immune-related adverse events (irAEs), including inflammatory art... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - April 29, 2024 Category: Rheumatology Authors: John A. Storwick, Herman Tam, Daniel G. Rosenbaum and Kristin Houghton Tags: Case Report Source Type: research
CD8+ T cell-based cancer immunotherapy
The immune system in humans is a defense department against both exogenous and endogenous hazards, where CD8+ T cells play a crucial role in opposing pathological threats. Various immunotherapies based on CD8+ T ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 29, 2024 Category: Research Authors: Yanxia Chen, Dingning Yu, Hui Qian, Yinghong Shi and Zhimin Tao Tags: Review Source Type: research
Alpha and Beta Radiation for Theragnostics
Targeted radionuclide therapy (TRT) has significantly evolved from its beginnings with iodine-131 to employing carrier molecules with beta emitting isotopes like lutetium-177. With the success of Lu-177-DOTATATE for neuroendocrine tumors and Lu-177-PSMA-617 for prostate cancer, several other beta emitting radioisotopes, such as Cu-67 and Tb-161, are being explored for TRT. The field has also expanded into targeted alpha therapy (TAT) with agents like radium-223 for bone metastases in prostate cancer, and several other alpha emitter radioisotopes with carrier molecules, such as Ac-225, and Pb-212 under clinical trials. Desp...
Source: PET Clinics - April 29, 2024 Category: Radiology Authors: Hong Song, George Sgouros Source Type: research
Structural Analysis of Human IgE Monoclonal Antibody Epitopes on Dust Mite Allergen Der p 2
Capsule summaryMajor mite allergen epitope mutants with decreased IgE reactivity, designed based on structurally determined conformational epitopes on the allergen, are the basis for designing future hypoallergens for immunotherapy. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 29, 2024 Category: Allergy & Immunology Authors: Alyssa Ball, Kriti Khatri, Jill Glesner, Lisa D. Vailes, Sabina W ünschmann, Scott A. Gabel, Geoffrey A. Mueller, Jian Zhang, R. Stokes Peebles, Martin D. Chapman, Scott A. Smith, Maksymilian Chruszcz, Anna Pomés Source Type: research
Analyses of tumor microenvironment in patients with advanced renal cell carcinoma receiving immunotherapy (Meet-URO 18 study)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Source: Future Oncology - April 29, 2024 Category: Cancer & Oncology Authors: Fabio Catalano Matteo Brunelli Alessio Signori Pasquale Rescigno Sebastiano Buti Luca Galli Massimiliano Spada Cristina Masini Francesca Galuppini Valerio Gaetano Vellone Gabriele Gaggero Marco Maruzzo Sara Merler Francesca Vignani Alessia Cavo Davide Bim Source Type: research
The S100 family is a prognostic biomarker and correlated with immune cell infiltration in pan-cancer
ConclusionOur analysis demonstrated the role of S100 family in formation of TME diversity and complexity, enabling deeper cognition of TME infiltration characterization and the development of personalized immunotherapy strategies targeting S100 family for unique tumor types. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 29, 2024 Category: Cancer & Oncology Source Type: research
The application of plant-exosome-like nanovesicles as improved drug delivery systems for cancer vaccines
AbstractThe use of cancer immunotherapeutics is currently increasing. Cancer vaccines, as a form of immunotherapy, are gaining much attention in the medical community since specific tumor-antigens can activate immune cells to induce an anti-tumor immune response. However, the delivery of cancer vaccines presents many issues for research scientists when designing cancer treatments and requires further investigation. Nanoparticles, synthetic liposomes, bacterial vectors, viral particles, and mammalian exosomes have delivered cancer vaccines. In contrast, the use of many of these nanotechnologies produces many issues of cytot...
Source: Hormones and Cancer - April 29, 2024 Category: Cancer & Oncology Source Type: research
Immunosuppressive tumor microenvironment and immunotherapy of hepatocellular carcinoma: current status and prospectives
Hepatocellular carcinoma (HCC) is a major health concern worldwide, with limited therapeutic options and poor prognosis. In recent years, immunotherapies such as immune checkpoint inhibitors (ICIs) have made g... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 29, 2024 Category: Hematology Authors: Ke-Yu Shen, Ying Zhu, Sun-Zhe Xie and Lun-Xiu Qin Tags: Review Source Type: research
