The global, regional, and national burden of cancer among adolescents and young adults in 204 countries and territories, 1990 –2019: a population-based study
We report on the latest estimates of burden of AYA cancers in 204 cou... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 9, 2021 Category: Hematology Authors: Yi Feng Wen, Meng Xuan Chen, Guosheng Yin, Ruitao Lin, Yu Jie Zhong, Qian Qian Dong and Hai Ming Wong Tags: Research Source Type: research

CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients
The chimera antigen receptor (CAR) T cell therapy is a novel and potential targeted therapy and has achieved satisfactory efficacy in patients with relapsed or refractory multiple myeloma (MM) in recent years.... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 9, 2021 Category: Hematology Authors: Mengying Ke, Liqing Kang, Ling Wang, Shu Yang, Yajun Wang, Haiyan Liu, Chunyan Gu, Hongming Huang and Ye Yang Tags: Letter to the Editor Source Type: research

Applications of single-cell sequencing in cancer research: progress and perspectives
Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and metabolomics sequencing, is a powerful tool to decipher the cellular and molecular landscape at a single-cell resolution... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 9, 2021 Category: Hematology Authors: Yalan Lei, Rong Tang, Jin Xu, Wei Wang, Bo Zhang, Jiang Liu, Xianjun Yu and Si Shi Tags: Review Source Type: research

Antibody-drug conjugates for the treatment of lymphoma: clinical advances and latest progress
Antibody-drug conjugates (ADCs) are a promising class of immunotherapies with the potential to specifically target tumor cells and ameliorate the therapeutic index of cytotoxic drugs. ADCs comprise monoclonal ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 5, 2021 Category: Hematology Authors: Yurou Chu, Xiangxiang Zhou and Xin Wang Tags: Review Source Type: research

Hemophagocytic lymphohistiocytosis after COVID-19 vaccination
Cases of thrombotic thrombocytopenia induced by coronavirus disease 2019 (COVID-19) vaccines have been reported recently. Herein, we describe the first case of another critical disorder, hemophagocytic lymphoh... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 4, 2021 Category: Hematology Authors: Liang V. Tang and Yu Hu Tags: Letter to the Editor Source Type: research

Nanomaterials for cancer therapy: current progress and perspectives
Cancer is a disease with complex pathological process. Current chemotherapy faces problems such as lack of specificity, cytotoxicity, induction of multi-drug resistance and stem-like cells growth. Nanomaterial... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 31, 2021 Category: Hematology Authors: Zhe Cheng, Maoyu Li, Raja Dey and Yongheng Chen Tags: Review Source Type: research

Low titers of SARS-CoV-2 neutralizing antibodies after first vaccination dose in cancer patients receiving checkpoint inhibitors
Vaccination for SARS-CoV-2 provides significant protection against the infection in the general population. However, only limited data exist for patients with cancer under systemic therapy. Based on this, our ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 31, 2021 Category: Hematology Authors: Evangelos Terpos, Flora Zagouri, Michalis Liontos, Aimilia D. Sklirou, Konstantinos Koutsoukos, Christos Markellos, Alexandros Briasoulis, Eleni-Dimitra Papanagnou, Ioannis P. Trougakos and Meletios-Athanasios Dimopoulos Tags: Letter to the Editor Source Type: research

Post-transplant cyclophosphamide containing regimens after matched sibling, matched unrelated and haploidentical donor transplants in patients with acute lymphoblastic leukemia in first complete remission, a comparative study of the ALWP of the EBMT
There is no information on the impact of donor type in allogeneic hematopoietic stem cell transplantation (HCT) using homogeneous graft-versus-host (GVHD) prophylaxis with post-transplant cyclophosphamide (PTC... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 28, 2021 Category: Hematology Authors: Jaime Sanz, Jacques-Emmanuel Galimard, Myriam Labopin, Boris Afanasyev, Moiseev Ivan Sergeevich, Emanuele Angelucci, Nicolaus Kr öger, Yener Koc, Fabio Ciceri, J. L. Diez-Martin, Mutlu Arat, Simona Sica, Montserrat Rovira, Mahmoud Aljurf, Johanna Tischer Tags: Research Source Type: research

TET2 and DNMT3A mutations and exceptional response to 4 ′-thio-2′-deoxycytidine in human solid tumor models
This study aims to investigate TET2/DNMT3A mutations and antitumor activity... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 26, 2021 Category: Hematology Authors: Sherry X. Yang, Melinda Hollingshead, Larry Rubinstein, Dat Nguyen, Angelo B. A. Larenjeira, Robert J. Kinders, Michael Difilippantonio and James H. Doroshow Tags: Research Source Type: research

CD38-directed CAR-T cell therapy: a novel immunotherapy strategy for relapsed acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment for acute myeloid leukemia (AML). However, most patients experience relapse after allo-HSCT, with a poor progn... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 25, 2021 Category: Hematology Authors: Qingya Cui, Chongsheng Qian, Nan Xu, Liqing Kang, Haiping Dai, Wei Cui, Baoquan Song, Jia Yin, Zheng Li, Xiaming Zhu, Changju Qu, Tianhui Liu, Wenhong Shen, Mingqing Zhu, Lei Yu, Depei Wu & hellip; Tags: Letter to the Editor Source Type: research

Postoperative circulating tumor DNA as markers of recurrence risk in stages II to III colorectal cancer
Precise methods for postoperative risk stratification to guide the administration of adjuvant chemotherapy (ACT) in localized colorectal cancer (CRC) are still lacking. Here, we conducted a prospective, observ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 17, 2021 Category: Hematology Authors: Gong Chen, Junjie Peng, Qian Xiao, Hao-Xiang Wu, Xiaojun Wu, Fulong Wang, Liren Li, Peirong Ding, Qi Zhao, Yaqi Li, Da Wang, Yang Shao, Hua Bao, Zhizhong Pan, Ke-Feng Ding, Sanjun Cai & hellip; Tags: Research Source Type: research

Fifth-week immunogenicity and safety of anti-SARS-CoV-2 BNT162b2 vaccine in patients with multiple myeloma and myeloproliferative malignancies on active treatment: preliminary data from a single institution
Safety and immunogenicity of BNT162b2 mRNA vaccine are unknown in hematological patients; both were evaluated prospectively in 42 patients with multiple myeloma (MM) and 50 with myeloproliferative malignancies... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 17, 2021 Category: Hematology Authors: Fulvia Pimpinelli, Francesco Marchesi, Giulia Piaggio, Diana Giannarelli, Elena Papa, Paolo Falcucci, Martina Pontone, Simona Di Martino, Valentina Laquintana, Antonia La Malfa, Enea Gino Di Domenico, Ornella Di Bella, Gianluca Falzone, Fabrizio Ensoli, B Tags: Research Source Type: research

Role of lysosomes in physiological activities, diseases, and therapy
Long known as digestive organelles, lysosomes have now emerged as multifaceted centers responsible for degradation, nutrient sensing, and immunity. Growing evidence also implicates role of lysosome-related mec... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 14, 2021 Category: Hematology Authors: Ziqi Zhang, Pengfei Yue, Tianqi Lu, Yang Wang, Yuquan Wei and Xiawei Wei Tags: Review Source Type: research

Immunotherapies targeting stimulatory pathways and beyond
Co-stimulatory and co-inhibitory molecules play a critical role in T cell function. Tumor cells escape immune surveillance by promoting immunosuppression. Immunotherapy targeting inhibitory molecules like anti... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 12, 2021 Category: Hematology Authors: Julian A. Marin-Acevedo, ErinMarie O. Kimbrough, Rami Manochakian, Yujie Zhao and Yanyan Lou Tags: Review Source Type: research

Long non-coding RNAs in brain tumors: roles and potential as therapeutic targets
Brain tumors are associated with adverse outcomes despite improvements in radiation therapy, chemotherapy, and photodynamic therapy. However, treatment approaches are evolving, and new biological phenomena are... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 12, 2021 Category: Hematology Authors: Sung-Hyun Kim, Key-Hwan Lim, Sumin Yang and Jae-Yeol Joo Tags: Review Source Type: research

Bispecific T cell engagers: an emerging therapy for management of hematologic malignancies
Harnessing the power of immune cells, especially T cells, to enhance anti-tumor activities has become a promising strategy in clinical management of hematologic malignancies. The emerging bispecific antibodies... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 3, 2021 Category: Hematology Authors: Zheng Tian, Ming Liu, Ya Zhang and Xin Wang Tags: Review Source Type: research

Allogeneic hematopoietic cell transplantation with cord blood versus mismatched unrelated donor with post-transplant cyclophosphamide in acute myeloid leukemia
Allogeneic hematopoietic cell transplantation (allo-HCT) using a mismatched unrelated donor (MMUD) and cord blood transplantation (CBT) are valid alternatives for patients without a fully human leukocyte antig... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 3, 2021 Category: Hematology Authors: Bhagirathbhai Dholaria, Myriam Labopin, Jaime Sanz, Annalisa Ruggeri, Jan Cornelissen, H élène Labussière-Wallet, Didier Blaise, Edouard Forcade, Patrice Chevallier, Anna Grassi, Ludmila Zubarovskaya, Jürgen Kuball, Patrice Ceballos, Fabio Ciceri, Fre Tags: Research Source Type: research

Oncogenetic landscape and clinical impact of IDH1 and IDH2 mutations in T-ALL
IDH1 and IDH2 mutations (IDH1/2Mut) are recognized as recurrent genetic alterations in acute myeloid leukemia (AML) and associated with both clinical impact and therapeutic opportunity due to the recent developme... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 3, 2021 Category: Hematology Authors: Mathieu Simonin, Aline Schmidt, Christophe Bontoux, Marie- Émilie Dourthe, Etienne Lengliné, Guillaume P. Andrieu, Ludovic Lhermitte, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Françoise Huguet, Isabelle Arnoux, Stéphane Ducassou, Elizabeth Tags: Rapid communication Source Type: research

Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy
Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are considered as specialized immune cells that can be genetically modified to obtain capable effector cells for adopt... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 1, 2021 Category: Hematology Authors: Ying Gong, Roel G. J. Klein Wolterink, Jianxiang Wang, Gerard M. J. Bos and Wilfred T. V. Germeraad Tags: Review Source Type: research

SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism
Evidence suggests that platelets may directly interact with SARS-CoV-2, raising the concern whether ACE2 receptor plays a role in this interaction. The current study showed that SARS-CoV-2 interacts with both ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 29, 2021 Category: Hematology Authors: Shu Shen, Jingyuan Zhang, Yaohui Fang, Sihong Lu, Jun Wu, Xin Zheng and Fei Deng Tags: Letter to the Editor Source Type: research

HLA-A2.1-restricted ECM1-derived epitope LA through DC cross-activation priming CD8+ T and NK cells: a novel therapeutic tumour vaccine
This study aimed to develop therapeutic tumour vaccines based on... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 28, 2021 Category: Hematology Authors: Zhaojin Yu, Wensi Liu, Ying He, Mingli Sun, Jiankun Yu, Xue Jiao, Qiang Han, Haichao Tang, Bing Zhang, Yunkai Xian, Jing Qi, Jing Gong, Wang Xin, Gang Shi, Fengping Shan, Rui Zhang & hellip; Tags: Research Source Type: research

Current and future treatment strategies in chronic lymphocytic leukemia
Treatment decisions for patients with chronic lymphocytic leukemia (CLL) are dependent on symptoms and classification into high-, medium-, or low-risk categories. The prognosis for CLL hinges, in part, on the ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 26, 2021 Category: Hematology Authors: Krish Patel and John M. Pagel Tags: Review Source Type: research

Targeting the metabolic vulnerability of acute myeloid leukemia blasts with a combination of venetoclax and 8-chloro-adenosine
BCL ‐2 inhibition through venetoclax (VEN) targets acute myeloid leukemia (AML) blast cells and leukemic stem cells (LSCs). Although VEN-containing regimens yield 60–70% clinical response rates, the vast majori... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 26, 2021 Category: Hematology Authors: Ralf Buettner, Le Xuan Truong Nguyen, Corey Morales, Min-Hsuan Chen, Xiwei Wu, Lisa S. Chen, Dinh Hoa Hoang, Servando Hernandez Vargas, Vinod Pullarkat, Varsha Gandhi, Guido Marcucci and Steven T. Rosen Tags: Research Source Type: research

Targeting MCL-1 in cancer: current status and perspectives
Myeloid leukemia 1 (MCL-1) is an antiapoptotic protein of the BCL-2 family that prevents apoptosis by binding to the pro-apoptotic BCL-2 proteins. Overexpression of MCL-1 is frequently observed in many tumor t... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 21, 2021 Category: Hematology Authors: Haolan Wang, Ming Guo, Hudie Wei and Yongheng Chen Tags: Review Source Type: research

Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy
Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme enzyme that catalyzes the oxidation of L-tryptophan. Functionally, IDO1 has played a pivotal role in cancer immune escape via catalyzing the initial step of the kynu... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 21, 2021 Category: Hematology Authors: Kai Tang, Ya-Hong Wu, Yihui Song and Bin Yu Tags: Review Source Type: research

Novel agents and regimens for hematological malignancies: recent updates from 2020 ASH annual meeting
Antibodies and chimeric antigen receptor-engineered T cells (CAR-T) are increasingly used for cancer immunotherapy. Small molecule inhibitors targeting cellular oncoproteins and enzymes such as BCR-ABL, JAK2, ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 21, 2021 Category: Hematology Authors: Jing-Zhou Hou, Jing Christine Ye, Jeffrey J. Pu, Hongtao Liu, Wei Ding, Hong Zheng and Delong Liu Tags: Review Source Type: research

CAR-T cells and BiTEs in solid tumors: challenges and perspectives
Chimeric antigen receptor (CAR)-modified T cells and BiTEs are both immunotherapies which redirect T cell specificity against a tumor-specific antigen through the use of antibody fragments. They demonstrated r... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 19, 2021 Category: Hematology Authors: Julien Edeline, Roch Houot, Aur élien Marabelle and Marion Alcantara Tags: Review Source Type: research

Impact of the COVID-19 pandemic on diagnosis, stage, and initial treatment of breast cancer in the Netherlands: a population-based study
The onset of the COVID-19 pandemic forced the Dutch national screening program to a halt and increased the burden on health care services, necessitating the introduction of specific breast cancer treatment rec... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 17, 2021 Category: Hematology Authors: Anouk H. Eijkelboom, Linda de Munck, Marie-Jeanne T. F. D. Vrancken Peeters, Mireille J. M. Broeders, Luc J. A. Strobbe, Monique E. M. M. Bos, Marjanka K. Schmidt, Cristina Guerrero Paez, Marjolein L. Smidt, Maud Bessems, Janneke Verloop, Sabine Linn, Mar Tags: Research Source Type: research

Stop hate crimes and racism
(Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 16, 2021 Category: Hematology Tags: Editorial Source Type: research

Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies
Bispecific T cell engagers (BiTEs) are an innovative class of immunotherapeutics that redirect T cells to tumor surface antigens. While efficacious against certain hematological malignancies, limited bioavaila... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 16, 2021 Category: Hematology Authors: Johannes P. W. Heidbuechel and Christine E. Engeland Tags: Review Source Type: research

Correction to: Alantolactone selectively ablates acute myeloid leukemia stem and progenitor cells
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 15, 2021 Category: Hematology Authors: Yahui Ding, Huier Gao, Yu Zhang, Ye Li, Neil Vasdev, Yingdai Gao, Yue Chen and Quan Zhang Tags: Correction Source Type: research

Effect of prior treatments on selinexor, bortezomib, and dexamethasone in previously treated multiple myeloma
Therapeutic regimens for previously treated multiple myeloma (MM) may not provide prolonged disease control and are often complicated by significant adverse events, including peripheral neuropathy. In patients... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 13, 2021 Category: Hematology Authors: Maria V. Mateos, Maria Gavriatopoulou, Thierry Facon, Holger W. Auner, Xavier Leleu, Roman H ájek, Meletios A. Dimopoulos, Sosana Delimpasi, Maryana Simonova, Ivan Špička, Ludĕk Pour, Iryna Kriachok, Halyna Pylypenko, Vadim Doronin, Ganna Usenko, Reub Tags: Letter to the Editor Source Type: research

CLK1/SRSF5 pathway induces aberrant exon skipping of METTL14 and Cyclin L2 and promotes growth and metastasis of pancreatic cancer
Both aberrant alternative splicing and m6A methylation play complicated roles in the development of pancreatic cancer (PC), while the relationship between these two RNA modifications remains unclear. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 13, 2021 Category: Hematology Authors: Shi Chen, Can Yang, Zu-Wei Wang, Jian-Fei Hu, Jing-Jing Pan, Cheng-Yu Liao, Jia-Qiang Zhang, Jiang-Zhi Chen, Yi Huang, Long Huang, Qian Zhan, Yi-Feng Tian, Bai-Yong Shen and Yao-Dong Wang Tags: Research Source Type: research

Targeting neddylation E2s: a novel therapeutic strategy in cancer
Ubiquitin-conjugating enzyme E2 M (UBE2M) and ubiquitin-conjugating enzyme E2 F (UBE2F) are the two NEDD8-conjugating enzymes of the neddylation pathway that take part in posttranslational modification and cha... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 7, 2021 Category: Hematology Authors: Yi-Chao Zheng, Yan-Jia Guo, Bo Wang, Chong Wang, M. A. A. Mamun, Ya Gao and Hong-Min Liu Tags: Review Source Type: research

Lactoferrin is required for early B cell development in C57BL/6 mice
Lactoferrin (Lf) is widely distributed in mammalian milk, various tissues, and their exocrine fluids and has many physiological functions, such as bacteriostasis, antivirus, and immunoregulation. Here, we prov... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 7, 2021 Category: Hematology Authors: Lingyu Wei, Can Liu, Jia Wang, Xiang Zheng, Qiu Peng, Qiurong Ye, Zailong Qin, Zhengshuo Li, Xiaoyue Zhang, Yangge Wu, Yuqing Wen, Xuemei Zhang, Qun Yan and Jian Ma Tags: Letter to the Editor Source Type: research

Novel therapies emerging in oncology to target the TGF- β pathway
The TGF- β signaling pathway governs key cellular processes under physiologic conditions and is deregulated in many pathologies, including cancer. TGF-β is a multifunctional cytokine that acts in a cell- and co... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 6, 2021 Category: Hematology Authors: Byung-Gyu Kim, Ehsan Malek, Sung Hee Choi, James J. Ignatz-Hoover and James J. Driscoll Tags: Review Source Type: research

Structure, function and inhibition of critical protein –protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins
Mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) is an important transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a master regulator for transcription of important genes ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 6, 2021 Category: Hematology Authors: Xin Li and Yongcheng Song Tags: Review Source Type: research

Outcome of haploidentical versus matched sibling donors in hematopoietic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Non-T-cell depleted haploidentical hematopoietic stem cell transplantation (HaploSCT) is being increasingly used in acute lymphoblastic leukemia (ALL) with improving patient outcomes. We have recently reported... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 1, 2021 Category: Hematology Authors: Arnon Nagler, Myriam Labopin, Mohamed Houhou, Mahmoud Aljurf, Ashrafsadat Mousavi, Rose-Marie Hamladji, Mohsen Al Zahrani, Sergey Bondarenko, Mutlu Arat, Emanuele Angelucci, Yener Koc, Zafer G ülbas, Simona Sica, Jean Henri Bourhis, Jonathan Canaani, Eol Tags: Research Source Type: research

HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A-dependent stabilization of ILF3 mRNA
N6-methyladenosine (m6A) modification is the most prevalent modification in eukaryotic RNAs while accumulating studies suggest that m6A aberrant expression plays an important role in cancer. HNRNPA2B1 is a m6A... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 1, 2021 Category: Hematology Authors: Fengjie Jiang, Xiaozhu Tang, Chao Tang, Zhen Hua, Mengying Ke, Chen Wang, Jiamin Zhao, Shengyao Gao, Artur Jurczyszyn, Siegfried Janz, Meral Beksac, Fenghuang Zhan, Chunyan Gu and Ye Yang Tags: Letter to the Editor Source Type: research

Myeloproliferative neoplasm-driving Calr frameshift promotes the development of pulmonary hypertension in mice
Frameshifts in the Calreticulin (CALR) exon 9 provide a recurrent driver mutation of essential thrombocythemia (ET) and primary myelofibrosis among myeloproliferative neoplasms (MPNs). Here, we generated knock-in... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 30, 2021 Category: Hematology Authors: Keiji Minakawa, Tetsuro Yokokawa, Koki Ueda, Osamu Nakajima, Tomofumi Misaka, Yusuke Kimishima, Kento Wada, Yusuke Tomita, Saori Miura, Yuka Sato, Kosaku Mimura, Koichi Sugimoto, Kazuhiko Nakazato, Kenneth E. Nollet, Kazuei Ogawa, Takayuki Ikezoe & hellip Tags: Letter to the Editor Source Type: research

Prostate cancer and PARP inhibitors: progress and challenges
Despite survival improvements achieved over the last two decades, prostate cancer remains lethal at the metastatic castration-resistant stage (mCRPC) and new therapeutic approaches are needed. Germinal and/or ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 29, 2021 Category: Hematology Authors: Diego Teyssonneau, Henri Margot, Mathilde Cabart, Myl ène Anonnay, Paul Sargos, Nam-Son Vuong, Isabelle Soubeyran, Nicolas Sevenet and Guilhem Roubaud Tags: Review Source Type: research

Therapeutic strategies in RET gene rearranged non-small cell lung cancer
The recent approvals by the Food and Drug Administration several tumor-agnostic drugs have resulted in a paradigm shift in cancer treatment from an organ/histology-specific strategy to biomarker-guided approac... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 26, 2021 Category: Hematology Authors: Leylah M. Drusbosky, Estelamari Rodriguez, Richa Dawar and Chukwuemeka V. Ikpeazu Tags: Review Source Type: research

Emerging agents and regimens for AML
Until recently, acute myeloid leukemia (AML) patients used to have limited treatment options, depending solely on cytarabine  + anthracycline (7 + 3) intensive chemotherapy and hypomethylating agents. Allogenei... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 23, 2021 Category: Hematology Authors: Hongtao Liu Tags: Review Source Type: research

Reduction of RUNX1 transcription factor activity by a CBFA2T3-mimicking peptide: application to B cell precursor acute lymphoblastic leukemia
B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) is the most common pediatric cancer. Identifying key players involved in proliferation of BCP-ALL cells is crucial to propose new therapeutic targets. Ru... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 20, 2021 Category: Hematology Authors: H élène Jakobczyk, Lydie Debaize, Benoit Soubise, Stéphane Avner, Jérémie Rouger-Gaudichon, Séverine Commet, Yan Jiang, Aurélien A. Sérandour, Anne-Gaëlle Rio, Jason S. Carroll, Christian Wichmann, Michael Lie-a-Ling, Georges Lacaud, Laurent Corc Tags: Research Source Type: research

Targeting chemokines for acute lymphoblastic leukemia therapy
Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by the malignant clonal expansion of lymphoid hematopoietic precursors. It is regulated by various signaling molecules such as cyt... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 20, 2021 Category: Hematology Authors: Zixi Hong, Zimeng Wei, Tian Xie, Lin Fu, Jiaxing Sun, Fuling Zhou, Muhammad Jamal, Qiuping Zhang and Liang Shao Tags: Review Source Type: research

Next generation of immune checkpoint inhibitors and beyond
The immune system is the core defense against cancer development and progression. Failure of the immune system to recognize and eliminate malignant cells plays an important role in the pathogenesis of cancer. ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 19, 2021 Category: Hematology Authors: Julian A. Marin-Acevedo, ErinMarie O. Kimbrough and Yanyan Lou Tags: Review Source Type: research

Low expression of TRAF3IP2-AS1 promotes progression of NONO-TFE3 translocation renal cell carcinoma by stimulating N6-methyladenosine of PARP1 mRNA and downregulating PTEN
NONO-TFE3 translocation renal cell carcinoma (NONO-TFE3 tRCC) is one subtype of RCCs associated with Xp11.2 translocation/TFE3 gene fusions RCC (Xp11.2 tRCCs). Long non-coding RNA (lncRNA) has attracted great att... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 19, 2021 Category: Hematology Authors: Lei Yang, Yi Chen, Ning Liu, QianCheng Shi, Xiaodong Han, Weidong Gan and Dongmei Li Tags: Research Source Type: research

Third-line therapy for chronic myeloid leukemia: current status and future directions
Chronic myeloid leukemia (CML) is driven by the BCR-ABL1 fusion protein, formed by a translocation between chromosomes 9 and 22 that creates the Philadelphia chromosome. The BCR-ABL1 fusion protein is an optim... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 18, 2021 Category: Hematology Authors: Jorge Cortes and Fabian Lang Tags: Review Source Type: research

Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy
Transgelin-2 is a 22 kDa actin-binding protein that has been proposed to act as an oncogenic factor, capable of contributing to tumorigenesis in a wide range of human malignancies. However, little is known whe... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 17, 2021 Category: Hematology Authors: Hye-Ran Kim, Jeong-Su Park, Jin-Hwa Park, Fatima Yasmin, Chang-Hyun Kim, Se Kyu Oh, Ik-Joo Chung and Chang-Duk Jun Tags: Research Source Type: research

Correction to: The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia
The original article [1] contains an error in Fig. 6b for the image of western blot panels. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - March 11, 2021 Category: Hematology Authors: Wen-Tao Wang, Tian-Qi Chen, Zhan-Cheng Zeng, Qi Pan, Wei Huang, Cai Han, Ke Fang, Lin-Yu Sun, Qian-Qian Yang, Dan Wang, Xue-Qun Luo, Yu-Meng Sun and Yue-Qin Chen Tags: Correction Source Type: research