Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple  negative breast cancer cells
TNBC is the most aggressive breast cancer with higher recurrence and mortality rate than other types of breast cancer. There is an urgent need for identification of therapeutic agents with unique mode of actio... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 20, 2021 Category: Hematology Authors: Yahui Ding, Xiaoping Chen, Can Liu, Weizhi Ge, Qin Wang, Xin Hao, Mengmeng Wang, Yue Chen and Quan Zhang Tags: Research Source Type: research

Prevalence and reclassification of BRCA1 and BRCA2 variants in a large, unselected Chinese Han breast cancer cohort
Accurate interpretation of BRCA1/2 variants is critical for risk assessment and precise treatment of breast cancer (BC). Hence, the establishment of an ethnicity-based BRCA1/2 variant database of the Chinese popu... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 18, 2021 Category: Hematology Authors: Yun Liu, Honglian Wang, Xin Wang, Jiaqi Liu, Junjian Li, Xiang Wang, Yun Zhang, Zhigang Bai, Qinghua Zhou, Ying Wu, Yi Shen, Xiaoling Weng, Fatao Liu, Jiancheng Guo, Lijun Di, Olivier Gires & hellip; Tags: Letter to the Editor Source Type: research

Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia
Exportin 1 (XPO1/CRM1) is a key mediator of nuclear export with relevance to multiple cancers, including chronic lymphocytic leukemia (CLL). Whole exome sequencing has identified hot-spot somatic XPO1 point mutat... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 15, 2021 Category: Hematology Authors: Janek S. Walker, Zachary A. Hing, Bonnie Harrington, Jordan Baumhardt, Hatice Gulcin Ozer, Amy Lehman, Brian Giacopelli, Larry Beaver, Katie Williams, Jordan N. Skinner, Casey B. Cempre, Qingxiang Sun, Sharon Shacham, Benjamin R. Stromberg, Matthew K. Sum Tags: Research Source Type: research

STOML2 potentiates metastasis of hepatocellular carcinoma by promoting PINK1-mediated mitophagy and regulates sensitivity to lenvatinib
Dysregulation of both mitochondrial biogenesis and mitophagy is critical to sustain oncogenic signaling pathways. However, the mechanism of mitophagy in promoting hepatocellular carcinoma (HCC) progression rem... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 14, 2021 Category: Hematology Authors: Yahui Zheng, Chong Huang, Lu Lu, Kangkang Yu, Jing Zhao, Mingquan Chen, Lu Liu, Qingfeng Sun, Zhifei Lin, Jianming Zheng, Jinhong Chen and Jubo Zhang Tags: Research Source Type: research

Targeting hypoxic tumor microenvironment in pancreatic cancer
Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic cancer harbors ample stromal... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 13, 2021 Category: Hematology Authors: Jinxin Tao, Gang Yang, Wenchuan Zhou, Jiangdong Qiu, Guangyu Chen, Wenhao Luo, Fangyu Zhao, Lei You, Lianfang Zheng, Taiping Zhang and Yupei Zhao Tags: Review Source Type: research

Observations on the use of Bruton ’s tyrosine kinase inhibitors in SAR-CoV-2 and cancer
Bruton ’s tyrosine kinase (BTK) inhibitors, drugs utilized in cancer, are being repurposed for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) (COVID-19). Recently, BTK inhibitors acalabrutinib and... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 13, 2021 Category: Hematology Authors: Brooke Benner and William E. Carson Tags: Letter to the Editor Source Type: research

The CXCL12gamma chemokine immobilized by heparan sulfate on stromal niche cells controls adhesion and mediates drug resistance in multiple myeloma
The survival and proliferation of multiple myeloma (MM) cells in the bone marrow (BM) critically depend on interaction with stromal cells expressing the chemokine CXCL12. CXCL12 regulates the homing to the BM ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 12, 2021 Category: Hematology Authors: Zemin Ren, Hildo Lantermans, Annemieke Kuil, Willem Kraan, Fernando Arenzana-Seisdedos, Marie Jos é Kersten, Marcel Spaargaren and Steven T. Pals Tags: Research Source Type: research

Efficacy and safety of geptanolimab (GB226) for relapsed or refractory peripheral T cell lymphoma: an open-label phase 2 study (Gxplore-002)
Peripheral T cell lymphoma (PTCL) is a rare disease and recent approved drugs for relapsed/refractory (r/r) PTCL provided limited clinical benefit. We conducted this study to evaluate the efficacy and safety o... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 12, 2021 Category: Hematology Authors: Yuankai Shi, Jianqiu Wu, Zhen Wang, Liling Zhang, Zhao Wang, Mingzhi Zhang, Hong Cen, Zhigang Peng, Yufu Li, Lei Fan, Ye Guo, Liping Ma, Jie Cui, Yuhuan Gao, Haiyan Yang, Hongyu Zhang & hellip; Tags: Research Source Type: research

The integration of immune checkpoint inhibitors with VEGF targeted agents in advanced gastric and gastroesophageal adenocarcinoma: a review on the rationale and results of early phase trials
Several targeted therapies have shown efficacy in patients with advanced gastric cancer (GC) and gastroesophageal junction adenocarcinoma (GEJC), including anti-angiogenic agents and immune checkpoint inhibito... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 12, 2021 Category: Hematology Authors: Anwaar Saeed, Robin Park and Weijing Sun Tags: Review Source Type: research

Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism
Key hepatic molecules linking gut dysbiosis and hepatocarcinogenesis remain largely unknown. Gut-derived gut microbiota contains pathogen-associated molecular patterns (PAMPs) that may circulate into the liver... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 7, 2021 Category: Hematology Authors: Yi Zhou, Liang Hu, Wenqing Tang, Dongping Li, Lijie Ma, Hongchun Liu, Shuncai Zhang, Xiaojie Zhang, Ling Dong, Xizhong Shen, She Chen, Ruyi Xue and Si Zhang Tags: Research Source Type: research

Regulation of PD-L1 expression in the tumor microenvironment
Programmed death-ligand 1 (PD-L1) on cancer cells engages with programmed cell death-1 (PD-1) on immune cells, contributing to cancer immune escape. For multiple cancer types, the PD-1/PD-L1 axis is the major ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 7, 2021 Category: Hematology Authors: Ming Yi, Mengke Niu, Linping Xu, Suxia Luo and Kongming Wu Tags: Review Source Type: research

Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in mice
Prior chemotherapy and/or underlying morbidity commonly leads to poor mobilisation of hematopoietic stem cells (HSC) for transplantation in cancer patients. Increasing the number of available HSC prior to mobi... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 6, 2021 Category: Hematology Authors: Simranpreet Kaur, Anuj Sehgal, Andy C. Wu, Susan M. Millard, Lena Batoon, Cheyenne J. Sandrock, Michelle Ferrari-Cestari, Jean-Pierre Levesque, David A. Hume, Liza J. Raggatt and Allison R. Pettit Tags: Research Source Type: research

Maintenance therapy in acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation
Relapse remains the main cause of treatment failure in acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Emerging evidence has demonstrated that AML patien... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 6, 2021 Category: Hematology Authors: Li Xuan and Qifa Liu Tags: Review Source Type: research

How we treat mature B-cell neoplasms (indolent B-cell lymphomas)
Mature B cell neoplasms, previously indolent non-Hodgkin lymphomas (iNHLs), are a heterogeneous group of malignancies sharing similar disease courses and treatment paradigms. Most patients with iNHL have an ex... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 6, 2021 Category: Hematology Authors: Melissa Lumish, Lorenzo Falchi, Brandon S. Imber, Michael Scordo, Gottfried von Keudell and Erel Joffe Tags: Review Source Type: research

HOMER3 facilitates growth factor-mediated β-Catenin tyrosine phosphorylation and activation to promote metastasis in triple negative breast cancer
HOMER family scaffolding proteins (HOMER1-3) play critical roles in the development and progression of human disease by regulating the assembly of signal transduction complexes in response to extrinsic stimuli... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 6, 2021 Category: Hematology Authors: Qinghua Liu, Lixin He, Siqi Li, Fengyan Li, Guangzheng Deng, Xinjian Huang, Muwen Yang, Yunyun Xiao, Xiangfu Chen, Ying Ouyang, Jinxin Chen, Xuxia Wu, Xi Wang, Libing Song and Chuyong Lin Tags: Research Source Type: research

NK cell-based cancer immunotherapy: from basic biology to clinical development
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in immune activation against abnormal cells. Different from events required for T cell activation, NK cell activat... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 6, 2021 Category: Hematology Authors: Sizhe Liu, Vasiliy Galat, Yekaterina Galat4, Yoo Kyung Annie Lee, Derek Wainwright and Jennifer Wu Tags: Review Source Type: research

MEK inhibitors for the treatment of non-small cell lung cancer
BRAF and KRAS are two key oncogenes in the RAS/RAF/MEK/MAPK signaling pathway. Concomitant mutations in both KRAS and BRAF genes have been identified in non-small cell lung cancer (NSCLC). They lead to the pro... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 5, 2021 Category: Hematology Authors: Jing Han, Yang Liu, Sen Yang, Xuan Wu, Hongle Li and Qiming Wang Tags: Review Source Type: research

The management of metastatic GIST: current standard and investigational therapeutics
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. The majority of GISTs harbor gain of function mutations in either KIT or PDGFR α. Determination of the G... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - January 5, 2021 Category: Hematology Authors: Ciara M. Kelly, Laura Gutierrez Sainz and Ping Chi Tags: Review Source Type: research

Novel targeted therapies of T cell lymphomas
T cell lymphomas (TCL) comprise a heterogeneous group of non-Hodgkin lymphomas (NHL) that often present at an advanced stage at the time of diagnosis and that most commonly have an aggressive clinical course. ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 31, 2020 Category: Hematology Authors: Katarzyna I żykowska, Karolina Rassek, Dorota Korsak and Grzegorz K. Przybylski Tags: Review Source Type: research

New agents and regimens for diffuse large B cell lymphoma
As a widely recognized standard regimen, R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) is able to cure two-thirds patients with diffuse large B cell lymphoma (DLBCL), and t... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 14, 2020 Category: Hematology Authors: Liang Wang, Lin-rong Li and Ken H. Young Tags: Review Source Type: research

MCL-1 inhibitors, fast-lane development of a new class of anti-cancer agents
Cell death escape is one of the most prominent features of tumor cells and closely linked to the dysregulation of members of the Bcl-2 family of proteins. Among those, the anti-apoptotic family member myeloid ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 11, 2020 Category: Hematology Authors: Arnold Bolomsky, Meike Vogler, Murat Cem K öse, Caroline A. Heckman, Grégory Ehx, Heinz Ludwig and Jo Caers Tags: Review Source Type: research

Impact of treatment delay due to the pandemic of COVID-19 on the efficacy of immunotherapy in head and neck cancer patients
Immunotherapy has been a new standard for recurrent/metastatic head and neck cancers (R/M HNC). One of the prominent characteristics of cancer immunotherapy is the induction of immune memory followed by endure... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 11, 2020 Category: Hematology Authors: Gaili Chen, Qiuji Wu, Huangang Jiang, Zheng Li, Xinying Hua, Xiaoyan Hu, Haijun Yu, Conghua Xie and Yahua Zhong Tags: Letter to the Editor Source Type: research

Trajectory of chemical cocktail-induced neutrophil reprogramming
We reported before for the first time that diverse differentiated ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 10, 2020 Category: Hematology Authors: Yi Zhou, Chuijin Wei, Shumin Xiong, Liaoliao Dong, Zhu Chen, Sai-Juan Chen and Lin Cheng Tags: Letter to the Editor Source Type: research

GD2 or HER2 targeting T cell engaging bispecific antibodies to treat osteosarcoma
The cure rate for metastatic osteosarcoma has not substantially improved over the past decades. Clinical trials of anti-HER2 trastuzumab or anti-GD2 dinutuximab for metastatic or refractory osteosarcoma were n... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 10, 2020 Category: Hematology Authors: Jeong A. Park and Nai-Kong V. Cheung Tags: Research Source Type: research

Natural killer cell-based immunotherapy for acute myeloid leukemia
Despite considerable progress has been achieved in the treatment of acute myeloid leukemia over the past decades, relapse remains a major problem. Novel therapeutic options aimed at attaining minimal residual ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 7, 2020 Category: Hematology Authors: Jing Xu and Ting Niu Tags: Review Source Type: research

Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy
Natural killer (NK) cells are a critical component of the innate immune system. Chimeric antigen receptors (CARs) re-direct NK cells toward tumor cells carrying corresponding antigens, creating major opportuni... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 7, 2020 Category: Hematology Authors: Ahmet Yilmaz, Hanwei Cui, Michael A. Caligiuri and Jianhua Yu Tags: Review Source Type: research

Abnormally activated OPN/integrin αVβ3/FAK signalling is responsible for EGFR-TKI resistance in EGFR mutant non-small-cell lung cancer
Acquired epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance limits the long-term clinical efficacy of tyrosine kinase-targeting drugs. Although most of the mechanisms of acquired ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 7, 2020 Category: Hematology Authors: Yulong Fu, Yang Zhang, Zhe Lei, Ting Liu, Tingting Cai, Anqi Wang, Wenwen Du, Yuanyuan Zeng, Jianjie Zhu, Zeyi Liu and Jian-an Huang Tags: Research Source Type: research

Proteomic signatures of 16 major types of human cancer reveal universal and cancer-type-specific proteins for the identification of potential therapeutic targets
Proteomic characterization of cancers is essential for a comprehensive understanding of key molecular aberrations. However, proteomic profiling of a large cohort of cancer tissues is often limited by the conve... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 7, 2020 Category: Hematology Authors: Yangying Zhou, T. Mamie Lih, Jianbo Pan, Naseruddin H öti, Mingming Dong, Liwei Cao, Yingwei Hu, Kyung-Cho Cho, Shao-Yung Chen, Rodrigo Vargas Eguez, Edward Gabrielson, Daniel W. Chan, Hui Zhang and Qing Kay Li Tags: Research Source Type: research

Targeting the Wnt/ β-catenin signaling pathway in cancer
The aberrant Wnt/ β-catenin signaling pathway facilitates cancer stem cell renewal, cell proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy response. Accumulated investi... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 4, 2020 Category: Hematology Authors: Ya Zhang and Xin Wang Tags: Review Source Type: research

RNA sequencing: new technologies and applications in cancer research
Over the past few decades, RNA sequencing has significantly progressed, becoming a paramount approach for transcriptome profiling. The revolution from bulk RNA sequencing to single-molecular, single-cell and s... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 4, 2020 Category: Hematology Authors: Mingye Hong, Shuang Tao, Ling Zhang, Li-Ting Diao, Xuanmei Huang, Shaohui Huang, Shu-Juan Xie, Zhen-Dong Xiao and Hua Zhang Tags: Review Source Type: research

Safety and clinical efficacy of BCMA CAR-T-cell therapy in multiple myeloma
B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR)-T-cell therapy is an emerging treatment option for multiple myeloma. The aim of this systematic review and meta-analysis was to determi... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 3, 2020 Category: Hematology Authors: Gils Roex, Marijke Timmers, Kristien Wouters, Diana Campillo-Davo, Donovan Flumens, Wilfried Schroyens, Yiwei Chu, Zwi N. Berneman, Eva Lion, Feifei Luo and S ébastien Anguille Tags: Research Source Type: research

Novel therapeutics in myeloproliferative neoplasms
Hyperactive signaling of the Janus-Associated Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) pathway is central to the pathogenesis of Philadelphia-chromosome-negative myeloproliferative ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 2, 2020 Category: Hematology Authors: Sangeetha Venugopal and John Mascarenhas Tags: Review Source Type: research

Interplay between endoplasmic reticulum stress and non-coding RNAs in cancer
To survive, cancer cells are subjected to various internal and external adverse factors, including genetic mutations, hypoxia, nutritional deficiencies, and drug toxicity. All of these factors result in the ac... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 2, 2020 Category: Hematology Authors: Tianming Zhao, Juan Du and Hui Zeng Tags: Review Source Type: research

Thrombocytopenia and thrombosis in hospitalized patients with COVID-19
As our understanding on coronavirus disease 2019 (COVID-19) deepens, it is increasingly recognized that COVID-19 is more than a respiratory condition. Thrombocytopenia and thromboembolic complications are a co... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 1, 2020 Category: Hematology Authors: Heng Mei, Lili Luo and Yu Hu Tags: Editorial Source Type: research

Targeting the myeloid checkpoint receptor SIRP α potentiates innate and adaptive immune responses to promote anti-tumor activity
Signal regulatory protein α (SIRPα) is a myeloid-lineage inhibitory receptor that restricts innate immunity through engagement of its cell surface ligand CD47. Blockade of the CD47–SIRPα interaction synergizes... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 30, 2020 Category: Hematology Authors: Tracy C. Kuo, Amy Chen, Ons Harrabi, Jonathan T. Sockolosky, Anli Zhang, Emma Sangalang, Laura V. Doyle, Steven E. Kauder, Danielle Fontaine, Sangeetha Bollini, Bora Han, Yang-Xin Fu, Janet Sim, Jaume Pons and Hong I. Wan Tags: Research Source Type: research

Blocking of Transient Receptor Potential Vanilloid 1 (TRPV1) promotes terminal mitophagy in multiple myeloma, disturbing calcium homeostasis and targeting ubiquitin pathway and bortezomib-induced unfolded protein response
Chemoresistance remains a major treatment obstacle in multiple myeloma (MM). Novel new therapies are thus in need. Transient Receptor Potential Vanilloid type 1 (TRPV1) is a calcium-permeable ion channel that ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 25, 2020 Category: Hematology Authors: Katia Beider, Evgenia Rosenberg, Valeria Dimenshtein-Voevoda, Yaarit Sirovsky, Julia Vladimirsky, Hila Magen, Olga Ostrovsky, Avichai Shimoni, Zohar Bromberg, Lola Weiss, Amnon Peled and Arnon Nagler Tags: Research Source Type: research

Targeting autophagy to overcome drug resistance: further developments
Inhibiting cell survival and inducing cell death are the main approaches of tumor therapy. Autophagy plays an important role on intracellular metabolic homeostasis by eliminating dysfunctional or unnecessary p... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 25, 2020 Category: Hematology Authors: Haocai Chang and Zhengzhi Zou Tags: Review Source Type: research

Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches
Aging drives the genetic and epigenetic changes that result in a decline in hematopoietic stem cell (HSC) functioning. Such changes lead to aging-related hematopoietic/immune impairments and hematopoietic diso... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 23, 2020 Category: Hematology Authors: Lei Zhang, Ryan Mack, Peter Breslin and Jiwang Zhang Tags: Review Source Type: research

The promising role of noncoding RNAs in cancer-associated fibroblasts: an overview of current status and future perspectives
As the most important component of the stromal cell population in the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) are crucial players in tumor initiation and progression. The interaction... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 19, 2020 Category: Hematology Authors: Zengli Fang, Jin Xu, Bo Zhang, Wei Wang, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Xianjun Yu and Si Shi Tags: Review Source Type: research

Therapeutic targeting of FLT3 and associated drug resistance in acute myeloid leukemia
Acute myeloid leukemia (AML) is a heterogeneous disease caused by several gene mutations and cytogenetic abnormalities affecting differentiation and proliferation of myeloid lineage cells. FLT3 is a receptor t... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 19, 2020 Category: Hematology Authors: Melat T. Gebru and Hong-Gang Wang Tags: Review Source Type: research

Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer
Mounting evidence has demonstrated the vital importance of tumor-associated macrophages (TAMs) and exosomes in the formation of the premetastatic niche. However, the molecular mechanisms by which tumor-derived... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 19, 2020 Category: Hematology Authors: Senlin Zhao, Yushuai Mi, Bingjie Guan, Binbin Zheng, Ping Wei, Yanzi Gu, Zhengxiang Zhang, Sanjun Cai, Ye Xu, Xinxiang Li, Xuefeng He, Xinyang Zhong, Guichao Li, Zhiyu Chen and Dawei Li Tags: Research Source Type: research

Pluripotent stem cell-derived CAR-macrophage cells with antigen-dependent anti-cancer cell functions
The Chimera antigen receptor (CAR)-T cell therapy has gained great success in the clinic. However, there are still major challenges for its wider applications in a variety of cancer types including lack of eff... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 11, 2020 Category: Hematology Authors: Li Zhang, Lin Tian, Xiaoyang Dai, Hua Yu, Jiajia Wang, Anhua Lei, Mengmeng Zhu, Jianpo Xu, Wei Zhao, Yuqing Zhu, Zhen Sun, Hao Zhang, Yongxian Hu, Yanlin Wang, Yuming Xu, George M. Church & hellip; Tags: Letter to the Editor Source Type: research

Immunosenescence: a key player in cancer development
Immunosenescence is a process of immune dysfunction that occurs with age and includes remodeling of lymphoid organs, leading to changes in the immune function of the elderly, which is closely related to the de... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 10, 2020 Category: Hematology Authors: Jingyao Lian, Ying Yue, Weina Yu and Yi Zhang Tags: Review Source Type: research

Isolation and characterization of exosomes for cancer research
Exosomes are a subset of extracellular vesicles that carry specific combinations of proteins, nucleic acids, metabolites, and lipids. Mounting evidence suggests that exosomes participate in intercellular commu... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 10, 2020 Category: Hematology Authors: Le Zhu, Hao-Ting Sun, Shun Wang, Sheng-Lin Huang, Yan Zheng, Chao-Qun Wang, Bei-Yuan Hu, Wei Qin, Tian-Tian Zou, Yan Fu, Xiao-Tian Shen, Wen-Wei Zhu, Yan Geng, Lu Lu, Hu-liang Jia, Lun-Xiu Qin & hellip; Tags: Review Source Type: research

Emerging agents and regimens for multiple myeloma
The outcomes of multiple myeloma (MM) have been improved significantly with the therapies incorporating proteasome inhibitors (PI), immunomodulatory drugs, monoclonal antibodies (MoAb) and stem cell transplant... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 9, 2020 Category: Hematology Authors: Yang Yang, Yi Li, Huiyao Gu, Mengmeng Dong and Zhen Cai Tags: Review Source Type: research

HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 pathway
Pyroptosis is a form of proinflammatory gasdermin-mediated programmed cell death. Abnormal mucosal inflammation in the intestine is a critical risk factor for colitis-associated colorectal cancer (CAC). Howeve... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 7, 2020 Category: Hematology Authors: Gao Tan, Chongyang Huang, Jiaye Chen and Fachao Zhi Tags: Rapid communication Source Type: research

The impact of the temporary suspension of national cancer screening programmes due to the COVID-19 epidemic on the diagnosis of breast and colorectal cancer in the Netherlands
Oncological care was largely derailed due to the reprioritisation of health care services to handle the initial surge of COVID-19 patients adequately. Cancer screening programmes were no exception in this repr... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 4, 2020 Category: Hematology Authors: Avinash G. Dinmohamed, Matteo Cellamare, Otto Visser, Linda de Munck, Marloes A. G. Elferink, Pieter J. Westenend, Jelle Wesseling, Mireille J. M. Broeders, Ernst J. Kuipers, Matthias A. W. Merkx, Iris D. Nagtegaal and Sabine Siesling Tags: Letter to the Editor Source Type: research

XPO1 expression worsens the prognosis of unfavorable DLBCL that can be effectively targeted by selinexor in the absence of mutant p53
The XPO1 inhibitor selinexor was recently approved in relapsed/refractory DLBCL patients but only demonstrated modest anti-DLBCL efficacy, prompting us to investigate the prognostic effect of XPO1 in DLBCL pat... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 4, 2020 Category: Hematology Authors: Manman Deng, Mingzhi Zhang, Zijun Y. Xu-Monette, Lan V. Pham, Alexandar Tzankov, Carlo Visco, Xiaosheng Fang, Govind Bhagat, Feng Zhu, Karen Dybkaer, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, William W. L. Choi, Jooryung Huh & hellip; Tags: Letter to the Editor Source Type: research

In vivo evaluation of CD38 and CD138 as targets for nanoparticle-based drug delivery in multiple myeloma
Drug-loaded nanoparticles have established their benefits in the fight against multiple myeloma; however, ligand-targeted nanomedicine has yet to successfully translate to the clinic due to insufficient effica... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 2, 2020 Category: Hematology Authors: David T. Omstead, Franklin Mejia, Jenna Sjoerdsma, Baksun Kim, Jaeho Shin, Sabrina Khan, Junmin Wu, Tanyel Kiziltepe, Laurie E. Littlepage and Basar Bilgicer Tags: Research Source Type: research

Burden, trends, and risk factors of esophageal cancer in China from 1990 to 2017: an up-to-date overview and comparison with those in Japan and South Korea
The epidemiology of esophageal cancer (EC) can elucidate its causes and risk factors and help develop prevention strategies. We aimed to provide an overview of the burden, trends, and risk factors of EC in Chi... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 2, 2020 Category: Hematology Authors: Si Yang, Shuai Lin, Na Li, Yujiao Deng, Meng Wang, Dong Xiang, Grace Xiang, Shuqian Wang, Xianghua Ye, Yi Zheng, Jia Yao, Zhen Zhai, Ying Wu, Jingjing Hu, Huafeng Kang and Zhijun Dai Tags: Research Source Type: research