Higher matrix stiffness as an independent initiator triggers epithelial-mesenchymal transition and facilitates HCC metastasis
Increased liver stiffness exerts a detrimental role in driving hepatocellular carcinoma (HCC) malignancy and progression, and indicates a high risk of unfavorable outcomes. However, it remains largely unknown ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 8, 2019 Category: Hematology Authors: Yinying Dong, Qiongdan Zheng, Zhiming Wang, Xiahui Lin, Yang You, Sifan Wu, Yaohui Wang, Chao Hu, Xiaoying Xie, Jie Chen, Dongmei Gao, Yan Zhao, Weizhong Wu, Yinkun Liu, Zhenggang Ren, Rongxin Chen & hellip; Tags: Research Source Type: research

CAR-T “the living drugs”, immune checkpoint inhibitors, and precision medicine: a new era of cancer therapy
New advances in the design and manufacture of monoclonal antibodies, bispecific T cell engagers, and antibody-drug conjugates make the antibody-directed agents more powerful with less toxicities. Small molecul... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 8, 2019 Category: Hematology Authors: Delong Liu Tags: Editorial Source Type: research

Immunotherapy in HER2-positive breast cancer: state of the art and future perspectives
Breast cancer (BC) is a complex disease with primary or acquired incurability characteristics in a significant part of patients. Immunotherapeutical agents represent an emerging option for breast cancer treatm... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - October 29, 2019 Category: Hematology Authors: E. Krasniqi, G. Barchiesi, L. Pizzuti, M. Mazzotta, A. Venuti, M. Maugeri-Sacc à, G. Sanguineti, G. Massimiani, D. Sergi, S. Carpano, P. Marchetti, S. Tomao, T. Gamucci, R. De Maria, F. Tomao, C. Natoli & hellip; Tags: Review Source Type: research

Emerging agents and regimens for hepatocellular carcinoma
Liver cancer, mostly hepatocellular carcinoma (HCC), is the second leading cause of cancer mortality globally. Most patients need at least one systemic therapy at different phases of their treatment for HCC. S... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - October 26, 2019 Category: Hematology Authors: Xiao-Dong Zhu and Hui-Chuan Sun Tags: Review Source Type: research

Correction to: Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells
The original article [1] contained an error in Fig. 7c whereby the same flow image was accidentally misused for the second and fourth group. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - October 24, 2019 Category: Hematology Authors: Lufeng Zheng, Qianqian Guo, Chenxi Xiang, Shijia Liu, Yuzhang Jiang, Lanlan Gao, Haiwei Ni, Ting Wang, Qiong Zhao, Hai Liu, Yingying Xing, Yaohui Wang, Xiaoman Li and Tao Xi Tags: Correction Source Type: research

Measurable residual disease at myeloablative allogeneic transplantation in adults with acute lymphoblastic leukemia: a retrospective registry study on 2780 patients from the acute leukemia working party of the EBMT
Assessment of measurable residual disease (MRD) is rapidly transforming the therapeutic and prognostic landscape of a wide range of hematological malignancies. Its prognostic value in acute lymphoblastic leuke... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - October 23, 2019 Category: Hematology Authors: Ji ří Pavlů, Myriam Labopin, Riitta Niittyvuopio, Gerard Socié, Ibrahim Yakoub-Agha, Depei Wu, Peter Remenyi, Jakob Passweg, Dietrich W. Beelen, Mahmoud Aljurf, Nicolaus Kröger, Hélène Labussière-Wallet, Zinaida Perić, Sebastian Giebel, Arnon Nag Tags: Research Source Type: research

RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia
Additional sex combs-like 1 (ASXL1) mutations have been described in all forms of myeloid neoplasms including chronic myelomonocytic leukemia (CMML) and associated with inferior outcomes, yet the molecular pathog... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - October 22, 2019 Category: Hematology Authors: Rabindranath Bera, Ming-Chun Chiu, Ying-Jung Huang, Tung-Huei Lin, Ming-Chung Kuo and Lee-Yung Shih Tags: Research Source Type: research

Myeloid-derived suppressor cells in hematological malignancies: friends or foes
Myeloid-derived suppressor cells (MDSCs) are newly identified immature myeloid cells that are characterized by the ability to suppress immune responses and expand during cancer, infection, and inflammatory dis... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - October 22, 2019 Category: Hematology Authors: Meng Lv, Ke Wang and Xiao-jun Huang Tags: Review Source Type: research

MAGE-A1 in lung adenocarcinoma as a promising target of chimeric antigen receptor T cells
Cancer/testis antigens (CTAs) are a special type of tumor antigen and are believed to act as potential targets for cancer immunotherapy. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - October 22, 2019 Category: Hematology Authors: Yuan Mao, Weifei Fan, Hao Hu, Louqian Zhang, Jerod Michel, Yaqin Wu, Jun Wang, Lizhou Jia, Xiaojun Tang, Li Xu, Yan Chen, Jin Zhu, Zhenqing Feng, Lin Xu, Rong Yin and Qi Tang Tags: Research Source Type: research

Global, regional, and national burden of Hodgkin lymphoma from 1990 to 2017: estimates from the 2017 Global Burden of Disease study
Hodgkin lymphoma (HL) is an uncommon B cell lymphoma. We assessed the global, regional, and national burden of HL from 1990 to 2017, by gender, age, and social-demographic index (SDI). (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - October 22, 2019 Category: Hematology Authors: Linghui Zhou, Yujiao Deng, Na Li, Yi Zheng, Tian Tian, Zhen Zhai, Si Yang, Qian Hao, Ying Wu, Dingli Song, Dai Zhang, Jun Lyu and Zhijun Dai Tags: Research Source Type: research

circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression
Circular RNAs (circRNAs) represent a type of endogenous noncoding RNAs that are generated by back-splicing events and favor repetitive sequences. Recent studies have reported that cancer-associated chromosomal... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - October 17, 2019 Category: Hematology Authors: Wei Huang, Ke Fang, Tian-Qi Chen, Zhan-Cheng Zeng, Yu-Meng Sun, Cai Han, Lin-Yu Sun, Zhen-Hua Chen, Qian-Qian Yang, Qi Pan, Xue-Qun Luo, Wen-Tao Wang and Yue-Qin Chen Tags: Research Source Type: research

APRIL and BAFF: novel biomarkers for central nervous system lymphoma
Early diagnosis of CNS lymphoma (CNSL) is essential for successful therapy of this rapidly progressing brain tumor. However, in patients presenting with focal brain lesions, fast and reliable diagnosis of PCNS... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - October 15, 2019 Category: Hematology Authors: Matthias Mulazzani, Marion Huber, Sabine Borchard, Sigrid Langer, Barbara Angele, Elisabeth Schuh, Edgar Meinl, Martin Dreyling, Tobias Birnbaum, Andreas Straube, Uwe Koedel and Louisa von Baumgarten Tags: Research Source Type: research

Heterogeneity of cancer-associated fibroblasts and roles in the progression, prognosis, and therapy of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a lethal disease, and recurrence and metastasis are the major causes of death in HCC patients. Cancer-associated fibroblasts (CAFs), a major stromal cell type in the HCC micro... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 23, 2019 Category: Hematology Authors: Zeli Yin, Chengyong Dong, Keqiu Jiang, Zhe Xu, Rui Li, Kun Guo, Shujuan Shao and Liming Wang Tags: Review Source Type: research

Recent drug approvals for acute myeloid leukemia
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, with an incidence that increases with age, and a generally poor prognosis. The disease is clinically and genetically heterogene... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 18, 2019 Category: Hematology Authors: Catherine Lai, Kimberley Doucette and Kelly Norsworthy Tags: Review Source Type: research

Prospects for combining immune checkpoint blockade with PARP inhibition
The immunogenicity of a cancer cell is derived from accumulated somatic mutations. However, on the contrary to increased immunogenicity, anti-cancer immune response tends to be feeble. This impaired anti-cance... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 14, 2019 Category: Hematology Authors: Anping Li, Ming Yi, Shuang Qin, Qian Chu, Suxia Luo and Kongming Wu Tags: Review Source Type: research

TCR-like antibodies in cancer immunotherapy
Cancer immunotherapy has been regarded as the most significant scientific breakthrough of 2013, and antibody therapy is at the core of this breakthrough. Despite significant success achieved in recent years, i... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 14, 2019 Category: Hematology Authors: Qinghua He, Zhaoyu Liu, Zhihua Liu, Yuxiong Lai, Xinke Zhou and Jinsheng Weng Tags: Review Source Type: research

Incidence and death in 29 cancer groups in 2017 and trend analysis from 1990 to 2017 from the Global Burden of Disease Study
This study aimed to quantitatively estimate the mortality, morbidity, and analyze the trends of ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 12, 2019 Category: Hematology Authors: Longfei Lin, Lei Yan, Yuling Liu, Fang Yuan, Hui Li and Jian Ni Tags: Research Source Type: research

Long noncoding RNA GSTM3TV2 upregulates LAT2 and OLR1 by competitively sponging let-7 to promote gemcitabine resistance in pancreatic cancer
Chemoresistance is one of the main causes of poor prognosis in pancreatic cancer patients. Understanding the mechanisms implicated in chemoresistance of pancreatic cancer is critical to improving patient outco... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 12, 2019 Category: Hematology Authors: Guangbing Xiong, Chang Liu, Gang Yang, Mengyu Feng, Jianwei Xu, Fangyu Zhao, Lei You, Li Zhou, Lianfang Zheng, Ya Hu, Xiaowo Wang, Taiping Zhang and Yupei Zhao Tags: Research Source Type: research

Antibody-drug conjugates in clinical trials for lymphoid malignancies and multiple myeloma
Antibody-drug conjugates (ADC) represent a distinct family of chemoimmunotherapy agents. ADCs are composed of monoclonal antibodies conjugated to cytotoxic payloads via specialized chemical linkers. ADCs there... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 10, 2019 Category: Hematology Authors: Bo Yu and Delong Liu Tags: Review Source Type: research

Cancer-associated adipocytes: key players in breast cancer progression
Adipocytes are one of the primary stromal cells in many tissues, and they are considered to play an active role in the tumor microenvironment. Cancer-associated adipocytes (CAAs) are not only found adjacent to... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 10, 2019 Category: Hematology Authors: Qi Wu, Bei Li, Zhiyu Li, Juanjuan Li, Si Sun and Shengrong Sun Tags: Review Source Type: research

Tumor neoantigens: from basic research to clinical applications
Tumor neoantigen is the truly foreign protein and entirely absent from normal human organs/tissues. It could be specifically recognized by neoantigen-specific T cell receptors (TCRs) in the context of major hi... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 6, 2019 Category: Hematology Authors: Tao Jiang, Tao Shi, Henghui Zhang, Jie Hu, Yuanlin Song, Jia Wei, Shengxiang Ren and Caicun Zhou Tags: Review Source Type: research

LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis
Long non-coding RNAs (lncRNAs) have been associated with non-small cell lung cancer (NSCLC), but the underlying molecular mechanisms of their specific roles in mediating aerobic glycolysis have been poorly exp... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 5, 2019 Category: Hematology Authors: Qian Hua, Mingming Jin, Baoming Mi, Fei Xu, Tian Li, Li Zhao, Jianjun Liu and Gang Huang Tags: Research Source Type: research

Immune checkpoint inhibitors of PD-L1 as cancer therapeutics
Since the discovery of immune checkpoint proteins, there has been a special interest in developing antibodies that block programmed cell death 1 receptor (PD-1) and programmed cell death receptor ligand 1 (PD-... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 5, 2019 Category: Hematology Authors: Akintunde Akinleye and Zoaib Rasool Tags: Review Source Type: research

Emerging therapeutic agents for genitourinary cancers
The treatment of genitourinary malignancies has dramatically evolved over recent years. Renal cell carcinoma, urothelial carcinoma of the bladder, and prostate adenocarcinoma are the most commonly encountered ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 4, 2019 Category: Hematology Authors: Kevin Zarrabi, Azzam Paroya and Shenhong Wu Tags: Review Source Type: research

CircRNAs in cancer metabolism: a review
Altered energy metabolism is a hallmark of tumors aiming at supplying necessary nutrients for tumorigenesis and development. These redirected metabolic pathways associated with carbohydrate, lipid and amino ac... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 4, 2019 Category: Hematology Authors: Tao Yu, Yanfen Wang, Yu Fan, Na Fang, Tongshan Wang, Tongpeng Xu and Yongqian Shu Tags: Review Source Type: research

Low-dose post-transplant cyclophosphamide and anti-thymocyte globulin as an effective strategy for GVHD prevention in haploidentical patients
Low-dose post-transplant cyclophosphamide (PTCy) in conjunction with anti-thymocyte globulin (ATG) appears as a potentially effective graft-versus-host disease (GVHD) prevention strategy in haploidentical hema... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 3, 2019 Category: Hematology Authors: Yu Wang, De-Pei Wu, Qi-Fa Liu, Lan-Ping Xu, Kai-Yan Liu, Xiao-Hui Zhang, Wen-Jing Yu, Yang Xu, Fen Huang and Xiao-Jun Huang Tags: Research Source Type: research

Who is the best haploidentical donor for acquired severe aplastic anemia? Experience from a multicenter study
Haploidentical transplantation has been proposed as an effective treatment for severe aplastic anemia (SAA). The majority of patients have more than one HLA-haploidentical donor. Herein, we compared the outcom... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 2, 2019 Category: Hematology Authors: Lan-Ping Xu, Shun-Qing Wang, Yan-Ru Ma, Su-Jun Gao, Yi-Fei Cheng, Yuan-Yuan Zhang, Wen-Jian Mo, Xiao-Dong Mo, Yu-Ping Zhang, Chen-Hua Yan, Yu-Hong Chen, Ming Zhou, Yu Wang, Xiao-Hui Zhang, Kai-Yan Liu and Xiao-Jun Huang Tags: Research Source Type: research

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy
Among all the stromal cells that present in the tumor microenvironment, cancer-associated fibroblasts (CAFs) are one of the most abundant and critical components of the tumor mesenchyme, which not only provide... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 28, 2019 Category: Hematology Authors: Tongyan Liu, Chencheng Han, Siwei Wang, Panqi Fang, Zhifei Ma, Lin Xu and Rong Yin Tags: Review Source Type: research

Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment
Plenty of immune cells infiltrate into the tumor microenvironment (TME) during tumor progression, in which myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of immature myeloid cell... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 22, 2019 Category: Hematology Authors: Xinyu Tian, Han Shen, Zhiyang Li, Tingting Wang and Shengjun Wang Tags: Review Source Type: research

CD33 splice site genotype was not associated with outcomes of patients receiving the anti-CD33 drug conjugate SGN-CD33A
We tested whether a single nucleotide polymorphism (SNP) that affects splicing of CD33 predicted response to treatment in adults with acute myeloid leukemia (AML) who received the novel CD33 antibody-drug conj... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 22, 2019 Category: Hematology Authors: Michele Stanchina, Alessandro Pastore, Sean Devlin, Christopher Famulare, Eytan Stein and Justin Taylor Tags: Letter to the Editor Source Type: research

Correction to: High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer
The original article [1] contains an error in Fig. 2 whereby Fig. 2D has mistakenly been omitted. Fig. 2 can be viewed in its entirety – including Fig. 2D – in this Correction article. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 26, 2019 Category: Hematology Authors: Wenwu Xiao, Weijie Ma, Sixi Wei, Qianping Li, Ruiwu Liu, Randy P. Carney, Kevin Yang, Joyce Lee, Alan Nyugen, Ken Y. Yoneda, Kit S. Lam and Tianhong Li Tags: Correction Source Type: research

Novel and emerging therapies for B cell lymphoma
Lymphomas are a heterogeneous group of lymphoproliferative disorders, with unique clinical and biological characteristics that exhibit variable response to therapy. Advances in chemo-immunotherapy have improve... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 25, 2019 Category: Hematology Authors: Sabarish Ayyappan and Kami Maddocks Tags: Review Source Type: research

Dual inhibition of IGF-IR and ALK as an effective strategy to eradicate NPM-ALK+ T-cell lymphoma
Nucleophosmin-anaplastic lymphoma kinase-expressing (NPM-ALK+) T cell lymphoma is an aggressive neoplasm. NPM-ALK, an oncogenic tyrosine kinase, plays a critical role in this lymphoma. Recently, selective ALK inh... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 24, 2019 Category: Hematology Authors: Bhawana George, Suraj Konnath George, Wenyu Shi, Abedul Haque, Ping Shi, Ghazaleh Eskandari, Magnus Axelson, Olle Larsson, Ahmed O. Kaseb and Hesham M. Amin Tags: Research Source Type: research

The long noncoding RNA H19 promotes tamoxifen resistance in breast cancer via autophagy
Tamoxifen resistance remains a clinical challenge for hormone receptor-positive breast cancer. Recently, dysregulations in autophagy have been suggested as a potential mechanism for tamoxifen resistance. Altho... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 24, 2019 Category: Hematology Authors: Ji Wang, Shuduo Xie, Jingjing Yang, Hanchu Xiong, Yunlu Jia, Yulu Zhou, Yongxia Chen, Xiaogang Ying, Cong Chen, Chenyang Ye, Linbo Wang and Jichun Zhou Tags: Research Source Type: research

Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancer
The biological function of protein arginine methyltransferase 3 (PRMT3) is not well known because very few physiological substrates of this methyltransferase have been identified to date. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 19, 2019 Category: Hematology Authors: Ming-Chuan Hsu, Ya-Li Tsai, Chia-Hsien Lin, Mei-Ren Pan, Yan-Shen Shan, Tsung-Yen Cheng, Skye Hung-Chun Cheng, Li-Tzong Chen and Wen-Chun Hung Tags: Research Source Type: research

Super-enhancers: critical roles and therapeutic targets in hematologic malignancies
Super-enhancers (SEs) in a broad range of human cell types are large clusters of enhancers with aberrant high levels of transcription factor binding, which are central to drive expression of genes in controlli... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 16, 2019 Category: Hematology Authors: Yunlu Jia, Wee-Joo Chng and Jianbiao Zhou Tags: Review Source Type: research

Emerging trends in immunotherapy for pediatric sarcomas
While promising, immunotherapy has yet to be fully unlocked for the preponderance of cancers where conventional chemoradiation reigns. This remains particularly evident in pediatric sarcomas where standard of ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 16, 2019 Category: Hematology Authors: Kyle A. Dyson, Brian D. Stover, Adam Grippin, Hector R. Mendez-Gomez, Joanne Lagmay, Duane A. Mitchell and Elias J. Sayour Tags: Review Source Type: research

Genomic landscape and its correlations with tumor mutational burden, PD-L1 expression, and immune cells infiltration in Chinese lung squamous cell carcinoma
To depict the genomic landscape of Chinese early-stage lung squamous cell carcinoma (LUSC) and investigate its correlation with tumor mutation burden (TMB), PD-L1 expression, and immune infiltrates. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 12, 2019 Category: Hematology Authors: Tao Jiang, Jinpeng Shi, Zhengwei Dong, Likun Hou, Chao Zhao, Xuefei Li, Beibei Mao, Wei Zhu, Xianchao Guo, Henghui Zhang, Ji He, Xiaoxia Chen, Chunxia Su, Shengxiang Ren, Chunyan Wu and Caicun Zhou Tags: Research Source Type: research

Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications
Tumor metastasis is a major contributor to the death of cancer patients. It is driven not only by the intrinsic alterations in tumor cells, but also by the implicated cross-talk between cancer cells and their ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 12, 2019 Category: Hematology Authors: Yuxin Lin, Jianxin Xu and Huiyin Lan Tags: Review Source Type: research

K+-Cl − cotransporter 1 (KCC1): a housekeeping membrane protein that plays key supplemental roles in hematopoietic and cancer cells
During the 1970s, a Na+-independent, ouabain-insensitive, N-ethylmaleimide-stimulated K+-Cl − cotransport mechanism was identified in red blood cells for the first time and in a variety of cell types afterward. Du... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 11, 2019 Category: Hematology Authors: A. P. Garneau, S. Slimani, L. E. Tremblay, M. J. Fiola, A. A. Marcoux and P. Isenring Tags: Review Source Type: research

Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors
Double/triple-hit lymphomas (DHL/THL) account for 5 –10% of diffuse large B cell lymphoma (DLBCL) with rearrangement of MYC and BCL2 and/or BCL6 resulting in MYC overexpression. Despite the poor prognosis of DHL, ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 9, 2019 Category: Hematology Authors: Weiping Li, Shiv K. Gupta, Weiguo Han, Ryan A. Kundson, Sara Nelson, Darlene Knutson, Patricia T. Greipp, Sherine F. Elsawa, Eduardo M. Sotomayor and Mamta Gupta Tags: Rapid communication Source Type: research

Nuclear factor of activated T-cells, NFATC1, governs FLT3ITD-driven hematopoietic stem cell transformation and a poor prognosis in AML
Acute myeloid leukemia (AML) patients with a high allelic burden of an internal tandem duplication (ITD)-mutated FMS-like Tyrosine Kinase-3 (FLT3) have a dismal outcome. FLT3ITD triggers the proliferation of the ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 8, 2019 Category: Hematology Authors: Maria Solovey, Ying Wang, Christian Michel, Klaus H. Metzeler, Tobias Herold, Joachim R. G öthert, Volker Ellenrieder, Elisabeth Hessmann, Stefan Gattenlöhner, Andreas Neubauer, Dinko Pavlinic, Vladimir Benes, Oliver Rupp and Andreas Burchert Tags: Research Source Type: research

Glyphosate induces benign monoclonal gammopathy and promotes multiple myeloma progression in mice
Glyphosate is the most widely used herbicide in the USA and worldwide. There has been considerable debate about its carcinogenicity. Epidemiological studies suggest that multiple myeloma (MM) and non-Hodgkin l... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 5, 2019 Category: Hematology Authors: Lei Wang, Qipan Deng, Hui Hu, Ming Liu, Zhaojian Gong, Shanshan Zhang, Zijun Y. Xu-Monette, Zhongxin Lu, Ken H. Young, Xiaodong Ma and Yong Li Tags: Research Source Type: research

Targeting mTOR for cancer therapy
Mechanistic target of rapamycin (mTOR) is a protein kinase regulating cell growth, survival, metabolism, and immunity. mTOR is usually assembled into several complexes such as mTOR complex 1/2 (mTORC1/2). In c... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 5, 2019 Category: Hematology Authors: Hui Hua, Qingbin Kong, Hongying Zhang, Jiao Wang, Ting Luo and Yangfu Jiang Tags: Review Source Type: research

Leukemia relapse following unmanipulated haploidentical transplantation: a risk factor analysis on behalf of the ALWP of the EBMT
As information on incidence, risk factors, and outcome of acute leukemia (AL) relapse after unmanipulated haploidentical stem cell transplantation (haplo-SCT) is scarce, a retrospective registry study was perf... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 4, 2019 Category: Hematology Authors: Simona Piemontese, Ariane Boumendil, Myriam Labopin, Christoph Schmid, Fabio Ciceri, William Arcese, Yener Koc, Zafar Gulbas, Johanna Tischer, Benedetto Bruno, Depei Wu, Didier Blaise, Dietrich Beelen, Giuseppe Irrera, Annalisa Ruggeri, Mohamed Houhou & h Tags: Research Source Type: research

Engineering switchable and programmable universal CARs for CAR T therapy
A traditional chimeric antigen receptor (CAR) has a fixed design, and one type of CAR T cells can only target one antigen epitope. This rigid design limits clinical application and leads to exceptionally high ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 4, 2019 Category: Hematology Authors: Delong Liu, Juanjuan Zhao and Yongping Song Tags: Review Source Type: research

Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia
The chromosomal rearrangements of the mixed-lineage leukemia gene MLL (KMT2A) have been extensively characterized as a potent oncogenic driver in leukemia. For its oncogenic function, most MLL-fusion proteins ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 28, 2019 Category: Hematology Authors: Krzysztof Brzezinka, Ekaterina Nevedomskaya, Ralf Lesche, Michael Steckel, Ashley L. Eheim, Andrea Haegebarth and Carlo Stresemann Tags: Research Source Type: research

Potential immune escape mechanisms underlying the distinct clinical outcome of immune checkpoint blockades in small cell lung cancer
Small cell lung cancer (SCLC) is one of the deadliest cancer types in the world. Despite the high response rate to frontline platinum-containing doublets, relapse is inevitable for the majority of patients and... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 28, 2019 Category: Hematology Authors: Yaru Tian, Xiaoyang Zhai, Anqin Han, Hui Zhu and Jinming Yu Tags: Review Source Type: research

Inflammasome inhibitors: promising therapeutic approaches against cancer
Inflammation has long been accepted as a key component of carcinogenesis. During inflammation, inflammasomes are potent contributors to the activation of inflammatory cytokines that lead to an inflammatory cas... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 26, 2019 Category: Hematology Authors: Shengchao Xu, Xizhe Li, Yuanqi Liu, Yu Xia, Ruimin Chang and Chunfang Zhang Tags: Review Source Type: research

Prospective target assessment and multimodal prediction of survival for personalized and risk-adapted treatment strategies in multiple myeloma in the GMMG-MM5 multicenter trial
Personalized and risk-adapted treatment strategies in multiple myeloma prerequisite feasibility of prospective assessment, reporting of targets, and prediction of survival probability in clinical routine. Our ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 26, 2019 Category: Hematology Authors: Dirk Hose, Susanne Beck, Hans Salwender, Martina Emde, Uta Bertsch, Christina Kunz, Christoph Scheid, Mathias H änel, Katja Weisel, Thomas Hielscher, Marc S. Raab, Hartmut Goldschmidt, Anna Jauch, Jérôme Moreaux and Anja Seckinger Tags: Research Source Type: research