A potent immunomodulatory role of exosomes derived from mesenchymal stromal cells in preventing cGVHD
Mesenchymal stromal cells (MSCs) are a promising therapy for preventing chronic Graft-Versus-Host Disease (cGVHD) due to their potent immunomodulatory properties. However, the safety concerns regarding the use... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 7, 2018 Category: Hematology Authors: Peilong Lai, Xiaomei Chen, Liyan Guo, Yulian Wang, Xialin Liu, Yan Liu, Tian Zhou, Tian Huang, Suxia Geng, Chengwei Luo, Xin Huang, Suijing Wu, Wei Ling, Xin Du, Chang He and Jianyu Weng Tags: Research Source Type: research

Advances in multiple omics of natural-killer/T cell lymphoma
Natural-killer/T cell lymphoma (NKTCL) represents the most common subtype of extranodal lymphoma with aggressive clinical behavior. Prevalent in Asians and South Americans, the pathogenesis of NKTCL remains to... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 4, 2018 Category: Hematology Authors: Jie Xiong and Wei-Li Zhao Tags: Review Source Type: research

FLT3 inhibitors in acute myeloid leukemia
FLT3 mutations are one of the most common findings in acute myeloid leukemia (AML). FLT3 inhibitors have been in active clinical development. Midostaurin as the first-in-class FLT3 inhibitor has been approved ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - December 4, 2018 Category: Hematology Authors: Mei Wu, Chuntuan Li and Xiongpeng Zhu Tags: Review Source Type: research

Universal CARs, universal T cells, and universal CAR T cells
Currently, the two approved T cell products with chimeric antigen receptors (CAR) are from autologous T cells. These CAR T cells approved for clinical use must be generated on a custom-made basis. This case-by... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 27, 2018 Category: Hematology Authors: Juanjuan Zhao, Quande Lin, Yongping Song and Delong Liu Tags: Review Source Type: research

Long non-coding RNAs in hematological malignancies: translating basic techniques into diagnostic and therapeutic strategies
Recent studies have revealed that non-coding regions comprise the vast majority of the human genome and long non-coding RNAs (lncRNAs) are a diverse class of non-coding RNAs that has been implicated in a varie... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 22, 2018 Category: Hematology Authors: Nonthaphat Kent Wong, Chien-Ling Huang, Rashidul Islam and Shea Ping Yip Tags: Review Source Type: research

Chimeric antigen receptor-modified T cell therapy in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL), a common type of B cell chronic lymphoproliferative disorder in adults, has witnessed enormous development in its treatment in recent years. New drugs such as ibrutinib, ide... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 20, 2018 Category: Hematology Authors: Yixin Zou, Wei Xu and Jianyong Li Tags: Review Source Type: research

Clinical utility of tumor genomic profiling in patients with high plasma circulating tumor DNA burden or metabolically active tumors
This retrospective study was undertaken to determine if the plasma circulating tumor DNA (ctDNA) level and tumor biological features in patients with advanced solid tumors affected the detection of genomic alt... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - November 6, 2018 Category: Hematology Authors: Cathy Zhou, Zilong Yuan, Weijie Ma, Lihong Qi, Angelique Mahavongtrakul, Ying Li, Hong Li, Jay Gong, Reggie R. Fan, Jin Li, Michael Molmen, Travis A. Clark, Dean Pavlick, Garrett M. Frampton, Brady Forcier, Elizabeth H. Moore & hellip; Tags: Research Source Type: research

Anti-BCMA CAR-T cells for treatment of plasma cell dyscrasia: case report on POEMS syndrome and multiple myeloma
POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome still has no standard treatment. On the basis that both POEMS syndrome and myeloma have an underlying plas... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - October 22, 2018 Category: Hematology Authors: Jinhuan Xu, Qiuxiang Wang, Hao Xu, Chaojiang Gu, Lijun Jiang, Jue Wang, Di Wang, Bin Xu, Xia Mao, Jin Wang, Zhiqiong Wang, Yi Xiao, Yicheng Zhang, Chunrui Li and Jianfeng Zhou Tags: Case report Source Type: research

Ex vivo and in vivo T cell-depleted allogeneic stem cell transplantation in patients with acute myeloid leukemia in first complete remission resulted in similar overall survival: on behalf of the ALWP of the EBMT and the MSKCC
Graft-versus-host disease (GVHD) is one of the leading causes of non-relapse mortality and morbidity after allogeneic hematopoietic stem cell transplantation (allo-HCT). (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - October 20, 2018 Category: Hematology Authors: Florent Malard, Myriam Labopin, Christina Cho, Didier Blaise, Esperanza B. Papadopoulos, Jakob Passweg, Richard O ’Reilly, Edouard Forcade, Molly Maloy, Liisa Volin, Hugo Castro-Malaspina, Yosr Hicheri, Ann A. Jakubowski, Corentin Orvain, Sergio Giralt, Tags: Research Source Type: research

Molecular profiling of hormone receptor-positive, HER2-negative breast cancers from patients treated with neoadjuvant endocrine therapy in the CARMINA 02 trial (UCBG-0609)
This study w... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - October 11, 2018 Category: Hematology Authors: Xu Liang, Adrien Briaux, V éronique Becette, Camille Benoist, Anais Boulai, Walid Chemlali, Anne Schnitzler, Sylvain Baulande, Sofia Rivera, Marie-Ange Mouret-Reynier, Laurence Venat Bouvet, Thibaut De La Motte Rouge, Jérôme Lemonnier, Florence Lerebou Tags: Research Source Type: research

Role of platelets and platelet receptors in cancer metastasis
The interaction of tumor cells with platelets is a prerequisite for successful hematogenous metastatic dissemination. Upon tumor cell arrival in the blood, tumor cells immediately activate platelets to form a ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - October 11, 2018 Category: Hematology Authors: Martin Schlesinger Tags: Review Source Type: research

Tim-3 expression and its role in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common tumors in the world, and its mortality is still on the rise. Limited treatments and low chemotherapy sensitivity of HCC make new therapeutic strategies ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - October 11, 2018 Category: Hematology Authors: Feifei Liu, Yanning Liu and Zhi Chen Tags: Review Source Type: research

Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis
In spite of major advances in treatment, multiple myeloma (MM) is currently an incurable malignancy due to the emergence of drug-resistant clones. We previously showed that MM cells upregulate the transcriptio... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - October 4, 2018 Category: Hematology Authors: Daniela N Petrusca, Denise Toscani, Feng-Ming Wang, Cheolkyu Park, Colin D Crean, Judith L Anderson, Silvia Marino, Khalid S Mohammad, Dan Zhou, Rebecca Silbermann, Quanhong Sun, Noriyoshi Kurihara, Deborah L Galson, Nicola Giuliani and G David Roodman Tags: Research Source Type: research

Cytokine release syndrome: grading, modeling, and new therapy
Genetically modified T cells that express a chimeric antigen receptor (CAR) are opening a new frontier in cancer immunotherapy. CAR T cells currently are in clinical trials for many cancer types. Cytokine rele... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 24, 2018 Category: Hematology Authors: Delong Liu and Juanjuan Zhao Tags: Review Source Type: research

A phase Ib study to assess the efficacy and safety of vismodegib in combination with ruxolitinib in patients with intermediate- or high-risk myelofibrosis
The JAK inhibitor (JAKi) ruxolitinib is standard treatment for myelofibrosis (MF), but some patients are unresponsive. Pre-clinical and clinical data suggest that addition of a Hedgehog pathway inhibitor (HPI)... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 24, 2018 Category: Hematology Authors: Stephen Couban, Giulia Benevolo, William Donnellan, Jennifer Cultrera, Steffen Koschmieder, Srdan Verstovsek, Gregory Hooper, Christian Hertig, Maneesh Tandon, Natalie Dimier, Vikram Malhi and Francesco Passamonti Tags: Letter to the Editor Source Type: research

Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development
Anlotinib is a new, orally administered tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor rece... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 19, 2018 Category: Hematology Authors: Guoshuang Shen, Fangchao Zheng, Dengfeng Ren, Feng Du, Qiuxia Dong, Ziyi Wang, Fuxing Zhao, Raees Ahmad and Jiuda Zhao Tags: Review Source Type: research

JAG1 overexpression contributes to Notch1 signaling and the migration of HTLV-1-transformed ATL cells
HTLV-1 is a retrovirus that infects over 20 million people worldwide and is responsible for the hematopoietic malignancy adult T cell leukemia (ATL). We previously demonstrated that Notch is constitutively act... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 19, 2018 Category: Hematology Authors: Marcia Bellon, Ramona Moles, Hassiba Chaib-Mezrag, Joanna Pancewicz and Christophe Nicot Tags: Research Source Type: research

Long non-coding RNAs in esophageal cancer: molecular mechanisms, functions, and potential applications
Esophageal cancer (EC) is the sixth leading cause of cancer-related death worldwide. The lack of early diagnostic biomarkers and effective prognostic indicators for metastasis and recurrence has resulted in th... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 17, 2018 Category: Hematology Authors: Min Su, Yuhang Xiao, Junliang Ma, Deliang Cao, Yong Zhou, Hui Wang, Qianjin Liao and Wenxiang Wang Tags: Review Source Type: research

Novel antibodies against GPIb α inhibit pulmonary metastasis by affecting vWF-GPIbα interaction
Platelet glycoprotein Ib α (GPIbα) extracellular domain, which is part of the receptor complex GPIb-IX-V, plays an important role in tumor metastasis. However, the mechanism through which GPIbα participates in ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 17, 2018 Category: Hematology Authors: Yingxue Qi, Wenchun Chen, Xinyu Liang, Ke Xu, Xiangyu Gu, Fengying Wu, Xuemei Fan, Shengxiang Ren, Junling Liu, Jun Zhang, Renhao Li, Jianwen Liu and Xin Liang Tags: Research Source Type: research

Organoid technology and applications in cancer research
During the past decade, the three-dimensional organoid technology has sprung up and become more and more popular among researchers. Organoids are the miniatures of in vivo tissues and organs, and faithfully re... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 15, 2018 Category: Hematology Authors: Hanxiao Xu, Xiaodong Lyu, Ming Yi, Weiheng Zhao, Yongping Song and Kongming Wu Tags: Review Source Type: research

Overexpression of CLC-3 is regulated by XRCC5 and is a poor prognostic biomarker for gastric cancer
Recently, many potential prognostic biomarkers for gastric cancer (GC) have been identified, but the prognosis of advanced GC patients remains poor. Chloride channels are promising cancer biomarkers, and their... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 14, 2018 Category: Hematology Authors: Zhuoyu Gu, Yixin Li, Xiaoya Yang, Meisheng Yu, Zhanru Chen, Chan Zhao, Lixin Chen and Liwei Wang Tags: Research Source Type: research

Selective killing of circulating tumor cells prevents metastasis and extends survival
Distant metastasis is initiated by circulating tumor cells (CTCs), which are considered to be a determining factor for the degree of metastasis and the survival of cancer patients. Although CTC-based diagnosti... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 10, 2018 Category: Hematology Authors: Yi Rang Kim, Jung Ki Yoo, Chang Wook Jeong and Jin Woo Choi Tags: Letter to the Editor Source Type: research

The lncRNA NEAT1 activates Wnt/ β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5
The long noncoding RNA nuclear-enriched abundant transcript 1 (NEAT1) has been reported to be overexpressed in colorectal cancer (CRC). However, its underlying mechanisms in the progression of CRC have not bee... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 5, 2018 Category: Hematology Authors: Meng Zhang, Weiwei Weng, Qiongyan Zhang, Yong Wu, Shujuan Ni, Cong Tan, Midie Xu, Hui Sun, Chenchen Liu, Ping Wei and Xiang Du Tags: Research Source Type: research

Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA
Mantle cell lymphoma (MCL) is an aggressive B-non-Hodgkin lymphoma with generally poor outcome. MCL is characterized by an aberrantly high cyclin D1-driven CDK4 activity. New molecular targeted therapies such ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 4, 2018 Category: Hematology Authors: Simon Heine, Markus Kleih, Neus Gim énez, Kathrin Böpple, German Ott, Dolors Colomer, Walter E. Aulitzky, Heiko van der Kuip and Elisabeth Silkenstedt Tags: Research Source Type: research

Histone deacetylase 6 in cancer
Histone acetylation and deacetylation are important epigenetic mechanisms that regulate gene expression and transcription. Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family that not only part... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 3, 2018 Category: Hematology Authors: Ting Li, Chao Zhang, Shafat Hassan, Xinyue Liu, Fengju Song, Kexin Chen, Wei Zhang and Jilong Yang Tags: Review Source Type: research

Haploidentical transplantation is associated with better overall survival when compared to single cord blood transplantation: an EBMT-Eurocord study of acute leukemia patients conditioned with thiotepa, busulfan, and fludarabine
Thiotepa-busulfan-fludarabine (TBF) is a widely used conditioning regimen in single umbilical cord blood transplantation (SUCBT). More recently, it was introduced in the setting of non-T cell depleted haploide... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 30, 2018 Category: Hematology Authors: Federica Giannotti, Myriam Labopin, Roni Shouval, Jaime Sanz, William Arcese, Emanuele Angelucci, Jorge Sierra, Josep-Maria Ribera Santasusana, Stella Santarone, Bruno Benedetto, Alessandro Rambaldi, Riccardo Saccardi, Didier Blaise, Michele Angelo Carell Tags: Research Source Type: research

Mouse avatar models of esophageal squamous cell carcinoma proved the potential for EGFR-TKI afatinib and uncovered Src family kinases involved in acquired resistance
No approved targeted agents are available for esophageal squamous cell carcinoma (ESCC). Informative genomic analysis and mouse patient-derived xenografts (PDX) also called mouse avatar can greatly expedite dr... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 29, 2018 Category: Hematology Authors: Zhentao Liu, Zuhua Chen, Jingyuan Wang, Mengqi Zhang, Zhongwu Li, Shubin Wang, Bin Dong, Cheng Zhang, Jing Gao and Lin Shen Tags: Research Source Type: research

The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models
The CNOT3 protein is a subunit of the CCR4-NOT complex, which is involved in mRNA degradation. We recently identified CNOT3 loss-of-function mutations in patients with T-cell acute lymphoblastic leukemia (T-ALL). (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 25, 2018 Category: Hematology Authors: Carmen Vicente, Rocco Stirparo, Sofie Demeyer, Charles E. de Bock, Olga Gielen, Mardelle Atkins, Jiekun Yan, Georg Halder, Bassem A. Hassan and Jan Cools Tags: Research Source Type: research

The roles of metallothioneins in carcinogenesis
Metallothioneins (MTs) are small cysteine-rich proteins that play important roles in metal homeostasis and protection against heavy metal toxicity, DNA damage, and oxidative stress. In humans, MTs have four ma... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 23, 2018 Category: Hematology Authors: Manfei Si and Jinghe Lang Tags: Review Source Type: research

Emerging roles of long non-coding RNAs in tumor metabolism
Compared with normal cells, tumor cells display distinct metabolic characteristics. Long non-coding RNAs (lncRNAs), a large class of regulatory RNA molecules with limited or no protein-coding capacity, play ke... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 22, 2018 Category: Hematology Authors: Hui Sun, Zhaohui Huang, Weiqi Sheng and Mi-die Xu Tags: Review Source Type: research

Simple deep sequencing-based post-remission MRD surveillance predicts clinical relapse in B-ALL
Next-generation sequencing (NGS) of the rearranged immunoglobulin heavy-chain gene has emerged as a highly sensitive method to detect minimal residual disease (MRD) in B acute lymphoblastic leukemia/lymphoma (... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 22, 2018 Category: Hematology Authors: Shuhua Cheng, Giorgio Inghirami, Shuo Cheng and Wayne Tam Tags: Research Source Type: research

Successful treatment of secondary poor graft function post allogeneic hematopoietic stem cell transplantation with eltrombopag
Poor graft function (PGF) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Current treatment strategies include the use of growth factors, CD34+-selected st... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 16, 2018 Category: Hematology Authors: Cen Tang, Feng Chen, Danqing Kong, Qinfen Ma, Haiping Dai, Jia Yin, Zheng Li, Jia Chen, Xiaming Zhu, Xinliang Mao, Depei Wu and Xiaowen Tang Tags: Letter to the Editor Source Type: research

Abscopal effect of radiotherapy combined with immune checkpoint inhibitors
Radiotherapy (RT) is used routinely as a standard treatment for more than 50% of patients with malignant tumors. The abscopal effect induced by local RT, which is considered as a systemic anti-tumor immune res... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 16, 2018 Category: Hematology Authors: Yang Liu, Yinping Dong, Li Kong, Fang Shi, Hui Zhu and Jinming Yu Tags: Review Source Type: research

Recombination of a dual-CAR-modified T lymphocyte to accurately eliminate pancreatic malignancy
The therapeutic application of T cells endowing with chimeric antigen receptors (CARs) is faced with “on-target, off-tumor” toxicity against solid tumors, particularly in the treatment of the pancreatic cancer... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 13, 2018 Category: Hematology Authors: Erhao Zhang, Peiwei Yang, Jieyi Gu, Heming Wu, Xiaowei Chi, Chen Liu, Ying Wang, Jianpeng Xue, Weiyan Qi, Qingbo Sun, Shengnan Zhang, Jialiang Hu and Hanmei Xu Tags: Research Source Type: research

Evaluation of an alternative ruxolitinib dosing regimen in patients with myelofibrosis: an open-label phase 2 study
Ruxolitinib improves splenomegaly and symptoms in patients with intermediate-2 or high-risk myelofibrosis; however, nearly half develop grade 3/4 anemia and/or thrombocytopenia, necessitating dose reductions a... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 7, 2018 Category: Hematology Authors: Moshe Talpaz, Susan Erickson-Viitanen, Kevin Hou, Solomon Hamburg and Maria R. Baer Tags: Research Source Type: research

Targeting the IDO1 pathway in cancer: from bench to bedside
Indoleamine 2, 3-dioxygenases (IDO1 and IDO2) and tryptophan 2, 3-dioxygenase (TDO) are tryptophan catabolic enzymes that catalyze the conversion of tryptophan into kynurenine. The depletion of tryptophan and ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 2, 2018 Category: Hematology Authors: Ming Liu, Xu Wang, Lei Wang, Xiaodong Ma, Zhaojian Gong, Shanshan Zhang and Yong Li Tags: Review Source Type: research

Targeting WEE1 to enhance conventional therapies for acute lymphoblastic leukemia
Despite the recent progress that has been made in the understanding and treatment of acute lymphoblastic leukemia (ALL), the outcome is still dismal in adult ALL cases. Several studies in solid tumors identifi... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 1, 2018 Category: Hematology Authors: Andrea Ghelli Luserna Di Ror à, Neil Beeharry, Enrica Imbrogno, Anna Ferrari, Valentina Robustelli, Simona Righi, Elena Sabattini, Maria Vittoria Verga Falzacappa, Chiara Ronchini, Nicoletta Testoni, Carmen Baldazzi, Cristina Papayannidis, Maria Chiara A Tags: Research Source Type: research

Function and clinical significance of circRNAs in solid tumors
Circular RNA (circRNA) is a new type of endogenous non-coding RNAs (ncRNAs). circRNA regulates gene expression in many biological processes, and it also participates in the initiation and development of variou... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 31, 2018 Category: Hematology Authors: Yiting Geng, Jingting Jiang and Changping Wu Tags: Review Source Type: research

Immune cell subset differentiation and tissue inflammation
Immune cells were traditionally considered as major pro-inflammatory contributors. Recent advances in molecular immunology prove that immune cell lineages are composed of different subsets capable of a vast ar... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 31, 2018 Category: Hematology Authors: Pu Fang, Xinyuan Li, Jin Dai, Lauren Cole, Javier Andres Camacho, Yuling Zhang, Yong Ji, Jingfeng Wang, Xiao-Feng Yang and Hong Wang Tags: Review Source Type: research

Frequency and clinical impact of CDKN2A/ARF/CDKN2B gene deletions as assessed by in-depth genetic analyses in adult T cell acute lymphoblastic leukemia
Recurrent deletions of the CDKN2A/ARF/CDKN2B genes encoded at chromosome 9p21 have been described in both pediatric and adult acute lymphoblastic leukemia (ALL), but their prognostic value remains controversial, ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 24, 2018 Category: Hematology Authors: E. Genesc à, A. Lazarenkov, M. Morgades, G. Berbis, N. Ruíz-Xivillé, P. Gómez-Marzo, J. Ribera, J. Juncà, A. González-Pérez, S. Mercadal, R. Guardia, M. T. Artola, M. J. Moreno, J. Martínez-López, L. Zamora, P. Barba & hellip; Tags: Letter to the Editor Source Type: research

Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy
Ubiquitination is a basic post-translational modification for cellular homeostasis, and members of the conjugating enzyme (E2) family are the key components of the ubiquitin –proteasome system. However, the rol... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 17, 2018 Category: Hematology Authors: Tong Shen, Ling-Dong Cai, Yu-Hong Liu, Shi Li, Wen-Juan Gan, Xiu-Ming Li, Jing-Ru Wang, Peng-Da Guo, Qun Zhou, Xing-Xing Lu, Li-Na Sun and Jian-Ming Li Tags: Research Source Type: research

Correction to: Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways
The original article [1] contained minor typesetting errors affecting the following authors: Ziang Jeff Gao, Xiao Zhen Zhou, and Kun Ping Lu. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 11, 2018 Category: Hematology Authors: Xiaolan Lian, Yu-Min Lin, Shingo Kozono, Megan K. Herbert, Xin Li, Xiaohong Yuan, Jiangrui Guo, Yafei Guo, Min Tang, Jia Lin, Yiping Huang, Bixin Wang, Chenxi Qiu, Cheng-Yu Tsai, Jane Xie, Ziang Jeff Gao & hellip; Tags: Correction Source Type: research

Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia
In this study, w... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 9, 2018 Category: Hematology Authors: Ling Xu, Danlin Yao, Jiaxiong Tan, Zifan He, Zhi Yu, Jie Chen, Gengxin Luo, Chunli Wang, Fenfang Zhou, Xianfeng Zha, Shaohua Chen and Yangqiu Li Tags: Letter to the Editor Source Type: research

Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells
Triple-negative breast cancer (TNBC) is an aggressive disease that currently lacks effective targeted therapy. NKG2D ligands (NKG2DLs) are expressed on various tumor types and immunosuppressive cells within tu... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 6, 2018 Category: Hematology Authors: Yali Han, Wei Xie, De-Gang Song and Daniel J. Powell Jr Tags: Research Source Type: research

T cell senescence and CAR-T cell exhaustion in hematological malignancies
T cell senescence has been recognized to play an immunosuppressive role in the aging population and cancer patients. Strategies dedicated to preventing or reversing replicative and premature T cell senescence ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 4, 2018 Category: Hematology Authors: Dimitri Kasakovski, Ling Xu and Yangqiu Li Tags: Review Source Type: research

Correction to: miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy
The original article [1] contains a spelling error in the authorship; the authors would like to note the correct spelling of the second author, Jiajia Xi. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 3, 2018 Category: Hematology Authors: Qian Huang, Jiajia Xi, Lei Wang, Xu Wang, Xiaodong Ma, Qipan Deng, Yong Lu, Munish Kumar, Zhiyuan Zhou, Ling Li, Zhaoyang Zeng, Ken H. Young, Qing Yi, Mingzhi Zhang and Yong Li Tags: Correction Source Type: research

Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression
Colorectal cancer (CRC) arises in a multistep molecular network process, which is from either discrete genetic perturbation or epigenetic dysregulation. The long non-coding RNAs (lncRNAs), emerging as key mole... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 3, 2018 Category: Hematology Authors: Yang Li, Changqian Zeng, Jialei Hu, Yue Pan, Yujia Shan, Bing Liu and Li Jia Tags: Research Source Type: research

Multi-center phase II trial of bortezomib and rituximab maintenance combination therapy in patients with mantle cell lymphoma after consolidative autologous stem cell transplantation
Mantle cell lymphoma (MCL) is an aggressive and incurable lymphoma. Standard of care for younger patients with MCL is induction chemotherapy followed by autologous stem cell transplantation (auto-HCT). Rituxim... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 28, 2018 Category: Hematology Authors: Robert W. Chen, Joycelynne M. Palmer, Sarah Tomassetti, Leslie L. Popplewell, Jessica Alluin, Pritsana Chomchan, Auayporn P. Nademanee, Tanya Siddiqi, Ni-Chun Tsai, Lu Chen, Fay Zuo, Rosemarie Abary, Ji-lian Cai, Alex F. Herrera, John J. Rossi, Steven T. Tags: Research Source Type: research

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer
The insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) plays essential roles in embryogenesis and carcinogenesis. IGF2BP1 serves as a post-transcriptional fine-tuner regulating the expression of som... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 28, 2018 Category: Hematology Authors: Xinwei Huang, Hong Zhang, Xiaoran Guo, Zongxin Zhu, Haibo Cai and Xiangyang Kong Tags: Review Source Type: research

Targeting ERBB2 mutations in solid tumors: biological and clinical implications
Preclinical data have shown that ERBB2 activating mutations are responsive to HER2 tyrosine kinase inhibitors. The aim of this study is to characterize the landscape of ERBB2 mutations in solid tumors and the ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 25, 2018 Category: Hematology Authors: Sophie Cousin, Emmanuel Khalifa, Amandine Crombe, Yech ’an Laizet, Carlo Lucchesi, Maud Toulmonde, Sylvestre Le Moulec, Céline Auzanneau, Isabelle Soubeyran and Antoine Italiano Tags: Letter to the Editor Source Type: research