A single-cell survey of cellular hierarchy in acute myeloid leukemia
Acute myeloid leukemia (AML) is a fatal hematopoietic malignancy and has a prognosis that varies with its genetic complexity. However, there has been no appropriate integrative analysis on the hierarchy of dif... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 25, 2020 Category: Hematology Authors: Junqing Wu, Yanyu Xiao, Jie Sun, Huiyu Sun, Haide Chen, Yuanyuan Zhu, Huarui Fu, Chengxuan Yu, Weigao E., Shujing Lai, Lifeng Ma, Jiaqi Li, Lijiang Fei, Mengmeng Jiang, Jingjing Wang, Fang Ye & hellip; Tags: Research Source Type: research

Advances in the assessment of minimal residual disease in mantle cell lymphoma
The clinical impact of minimal residual disease detection at early time points or during follow-ups has been shown to accurately predict relapses among patients with lymphomas, mainly in follicular and diffuse... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 24, 2020 Category: Hematology Authors: Dayoung Jung, Preetesh Jain, Yixin Yao and Michael Wang Tags: Review Source Type: research

A WEE1 family business: regulation of mitosis, cancer progression, and therapeutic target
The inhibition of the DNA damage response (DDR) pathway in the treatment of cancer has recently gained interest, and different DDR inhibitors have been developed. Among them, the most promising ones target the... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 21, 2020 Category: Hematology Authors: Andrea Ghelli Luserna di Ror à, Claudio Cerchione, Giovanni Martinelli and Giorgia Simonetti Tags: Review Source Type: research

BCMA-targeted immunotherapy for multiple myeloma
B cell maturation antigen (BCMA) is a novel treatment target for multiple myeloma (MM) due to its highly selective expression in malignant plasma cells (PCs). Multiple BCMA-targeted therapeutics, including ant... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 17, 2020 Category: Hematology Authors: Bo Yu, Tianbo Jiang and Delong Liu Tags: Review Source Type: research

Tie2-mediated vascular remodeling by ferritin-based protein C nanoparticles confers antitumor and anti-metastatic activities
Conventional therapeutic approaches for tumor angiogenesis, which are primarily focused on the inhibition of active angiogenesis to starve cancerous cells, target the vascular endothelial growth factor signali... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 14, 2020 Category: Hematology Authors: Young Sun Choi, Hyeonha Jang, Biki Gupta, Ji-Hak Jeong, Yun Ge, Chul Soon Yong, Jong Oh Kim, Jong-Sup Bae, Im-Sook Song, In-San Kim and You Mie Lee Tags: Research Source Type: research

Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance
Extrachromosomal circular DNA was recently found to be particularly abundant in multiple human cancer cells, although its frequency varies among different tumor types. Elevated levels of extrachromosomal circu... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 14, 2020 Category: Hematology Authors: Yuanliang Yan, Guijie Guo, Jinzhou Huang, Ming Gao, Qian Zhu, Shuangshuang Zeng, Zhicheng Gong and Zhijie Xu Tags: Review Source Type: research

Efficacy and safety of CD19 CAR T constructed with a new anti-CD19 chimeric antigen receptor in relapsed or refractory acute lymphoblastic leukemia
Recent evidence suggests that resistance to CD19 chimeric antigen receptor (CAR)-modified T cell therapy may be due to the presence of CD19 isoforms that lose binding to the single-chain variable fragment (scF... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 7, 2020 Category: Hematology Authors: Runxia Gu, Fang Liu, Dehui Zou, Yingxi Xu, Yang Lu, Bingcheng Liu, Wei Liu, Xiaojuan Chen, Kaiqi Liu, Ye Guo, Xiaoyuan Gong, Rui Lv, Xia Chen, Chunlin Zhou, Mengjun Zhong, Huijun Wang & hellip; Tags: Research Source Type: research

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19
Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic state that places them at a dramatically increased lethal risk. Although platelet activation is critical for thrombosis and is respo... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 4, 2020 Category: Hematology Authors: Si Zhang, Yangyang Liu, Xiaofang Wang, Li Yang, Haishan Li, Yuyan Wang, Mengduan Liu, Xiaoyan Zhao, Youhua Xie, Yan Yang, Shenghui Zhang, Zhichao Fan, Jianzeng Dong, Zhenghong Yuan, Zhongren Ding, Yi Zhang & hellip; Tags: Research Source Type: research

tRNA-derived RNA fragments in cancer: current status and future perspectives
Non-coding RNAs (ncRNAs) have been the focus of many studies over the last few decades, and their fundamental roles in human diseases have been well established. Transfer RNAs (tRNAs) are housekeeping ncRNAs t... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 4, 2020 Category: Hematology Authors: Mengqian Yu, Bingjian Lu, Jisong Zhang, Jinwang Ding, Pengyuan Liu and Yan Lu Tags: Review Source Type: research

Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation
Synthetic lethality is a lethal phenomenon in which the occurrence of a single genetic event is tolerable for cell survival, whereas the co-occurrence of multiple genetic events results in cell death. The main... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 3, 2020 Category: Hematology Authors: Win Topatana, Sarun Juengpanich, Shijie Li, Jiasheng Cao, Jiahao Hu, Jiyoung Lee, Kenneth Suliyanto, Diana Ma, Bin Zhang, Mingyu Chen and Xiujun Cai Tags: Review Source Type: research

Modeling tumor development and metastasis using paired organoids derived from patients with colorectal cancer liver metastases
Tumor metastasis accounts for the majority of cancer-related deaths; it is therefore important to develop preclinical models that faithfully recapitulate disease progression. Here, we generated paired organoid... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 3, 2020 Category: Hematology Authors: He Li, Weixing Dai, Xi Xia, Renjie Wang, Jing Zhao, Lingyu Han, Shaobo Mo, Wenqiang Xiang, Lin Du, Guangya Zhu, Jingjing Xie, Jun Yu, Nan Liu, Mingzhu Huang, Jidong Zhu and Guoxiang Cai Tags: Letter to the Editor Source Type: research

Roles of METTL3 in cancer: mechanisms and therapeutic targeting
N6-methyladenosine (m6A) is the most abundant mRNA modification and is catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is the sole catalytic subunit. Accumulating evidence i... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 27, 2020 Category: Hematology Authors: Chengwu Zeng, Wanxu Huang, Yangqiu Li and Hengyou Weng Tags: Review Source Type: research

HMGB1 in inflammation and cancer
High mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein widely distributed in eukaryotic cells and is involved in DNA damage repair and genomic stability maintenance. In response to sti... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 24, 2020 Category: Hematology Authors: Shumin Wang and Yi Zhang Tags: Editorial Source Type: research

Daratumumab, bortezomib, and dexamethasone in relapsed or refractory multiple myeloma: subgroup analysis of CASTOR based on cytogenetic risk
Multiple myeloma (MM) patients with high cytogenetic risk have poor outcomes. In CASTOR, daratumumab plus bortezomib/dexamethasone (D-Vd) prolonged progression-free survival (PFS) versus bortezomib/dexamethaso... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 20, 2020 Category: Hematology Authors: Katja Weisel, Andrew Spencer, Suzanne Lentzsch, Herv é Avet-Loiseau, Tomer M. Mark, Ivan Spicka, Tamas Masszi, Birgitta Lauri, Mark-David Levin, Alberto Bosi, Vania Hungria, Michele Cavo, Je-Jung Lee, Ajay Nooka, Hang Quach, Markus Munder & hellip; Tags: Research Source Type: research

Targeting EphA2 in cancer
Eph receptors and the corresponding Eph receptor-interacting (ephrin) ligands jointly constitute a critical cell signaling network that has multiple functions. The tyrosine kinase EphA2, which belongs to the f... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 18, 2020 Category: Hematology Authors: Ta Xiao, Yuhang Xiao, Wenxiang Wang, Yan Yan Tang, Zhiqiang Xiao and Min Su Tags: Review Source Type: research

The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy
Cancer is characterized as a complex disease caused by coordinated alterations of multiple signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined pathways in cancer biology, and it... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 17, 2020 Category: Hematology Authors: Jimin Yuan, Xiaoduo Dong, Jiajun Yap and Jiancheng Hu Tags: Review Source Type: research

ETV4 promotes late development of prostatic intraepithelial neoplasia and cell proliferation through direct and p53-mediated downregulation of p21
ETV4 is one of the ETS proteins overexpressed in prostate cancer (PC) as a result of recurrent chromosomal translocations. In human prostate cell lines, ETV4 promotes migration, invasion, and proliferation; ho... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 13, 2020 Category: Hematology Authors: Irene Cosi, Annamaria Pellecchia, Emanuele De Lorenzo, Eugenio Torre, Michela Sica, Gabriella Nesi, Rosario Notaro and Maria De Angioletti Tags: Research Source Type: research

Targeting immune checkpoints in hematological malignancies
Immune checkpoint blockade (ICB) therapies such as anti-programmed death 1 (PD-1) and anti-CTLA-4 (cytotoxic T lymphocyte-associated protein 4) have dramatically transformed treatment in solid tumor oncology. ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 12, 2020 Category: Hematology Authors: Basit Salik, Mark J. Smyth and Kyohei Nakamura Tags: Review Source Type: research

Principles and innovative technologies for decrypting noncoding RNAs: from discovery and functional prediction to clinical application
Noncoding RNAs (ncRNAs) are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including d... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 10, 2020 Category: Hematology Authors: Yu-Meng Sun and Yue-Qin Chen Tags: Review Source Type: research

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity
In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has achieved considerable success in the clinic. However, ICIs are significantly limited by the fact that only one third of pa... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 10, 2020 Category: Hematology Authors: Rong Tang, Jin Xu, Bo Zhang, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Xianjun Yu and Si Shi Tags: Review Source Type: research

The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myeloma
Multiple Myeloma (MM) is a hematological malignancy with genomic heterogeneity and poor survival outcome. Apart from the central role of genetic lesions, epigenetic anomalies have been identified as drivers in... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 6, 2020 Category: Hematology Authors: Samrat Roy Choudhury, Cody Ashby, Ruslana Tytarenko, Michael Bauer, Yan Wang, Shayu Deshpande, Judith Den, Carolina Schinke, Maurizio Zangari, Sharmilan Thanendrarajan, Faith E. Davies, Frits van Rhee, Gareth J. Morgan and Brian A. Walker Tags: Research Source Type: research

Correction to: m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 3, 2020 Category: Hematology Authors: Dan Jin, Jiwei Guo, Yan Wu, Jing Du, Lijuan Yang, Xiaohong Wang, Weihua Di, Baoguang Hu, Jiajia An, Lingqun Kong, Lei Pan and Guoming Su Tags: Correction Source Type: research

Dendritic cell biology and its role in tumor immunotherapy
As crucial antigen presenting cells, dendritic cells (DCs) play a vital role in tumor immunotherapy. Taking into account the many recent advances in DC biology, we discuss how DCs (1) recognize pathogenic anti... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 3, 2020 Category: Hematology Authors: Yingying Wang, Ying Xiang, Victoria W. Xin, Xian-Wang Wang, Xiao-Chun Peng, Xiao-Qin Liu, Dong Wang, Na Li, Jun-Ting Cheng, Yan-Ning Lyv, Shu-Zhong Cui, Zhaowu Ma, Qing Zhang and Hong-Wu Xin Tags: Review Source Type: research

EZH2: a novel target for cancer treatment
Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of polycomb repressive complex 2 (PRC2) that can alter downstream target genes expression by trimethylation of Lys-27 in histone 3 (H3K27me3). ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 28, 2020 Category: Hematology Authors: Ran Duan, Wenfang Du and Weijian Guo Tags: Review Source Type: research

SBRT combined with PD-1/PD-L1 inhibitors in NSCLC treatment: a focus on the mechanisms, advances, and future challenges
Immune checkpoint inhibitors targeting programmed cell death 1 (PD-1), programmed cell death ligand-1 (PD-L1), and others have shown potent clinical efficacy and have revolutionized the treatment protocols of ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 28, 2020 Category: Hematology Authors: Yu Chen, Min Gao, Zhaoqin Huang, Jinming Yu and Xiangjiao Meng Tags: Review Source Type: research

Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies
Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that utilize the ubiquitin proteasome system (UPS) to degrade proteins of interest (POI). PROTACs are potentially superior to con... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 27, 2020 Category: Hematology Authors: Yonghan He, Sajid Khan, Zhiguang Huo, Dongwen Lv, Xuan Zhang, Xingui Liu, Yaxia Yuan, Robert Hromas, Mingjiang Xu, Guangrong Zheng and Daohong Zhou Tags: Review Source Type: research

Correction to: The design and development of covalent protein-protein interaction inhibitors for cancer treatment
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 24, 2020 Category: Hematology Authors: Sha-Sha Cheng, Guan-Jun Yang, Wanhe Wang, Chung-Hang Leung and Dik-Lung Ma Tags: Correction Source Type: research

Crosstalks between inflammasome and autophagy in cancer
Both inflammasomes and autophagy have important roles in the intracellular homeostasis, inflammation, and pathology; the dysregulation of these processes is often associated with the pathogenesis of numerous c... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 23, 2020 Category: Hematology Authors: Chaeuk Chung, Wonhyoung Seo, Prashanta Silwal and Eun-Kyeong Jo Tags: Review Source Type: research

Roles of hsa-miR-12462 and SLC9A1 in acute myeloid leukemia
In this study, we defined a novel miRNA,... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 23, 2020 Category: Hematology Authors: Yan Jia, Wei Liu, Hui-En Zhan, Xiao-Ping Yi, Hui Liang, Qi-Li Zheng, Xin-Ya Jiang, Hai-Yan Zhou, Liang Zhao, Xie-Lan Zhao and Hui Zeng Tags: Letter to the Editor Source Type: research

Epidemiological trends of tracheal, bronchus, and lung cancer at the global, regional, and national levels: a population-based study
We examined the tracheal, bronchus, an... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 20, 2020 Category: Hematology Authors: Yujiao Deng, Peng Zhao, Linghui Zhou, Dong Xiang, Jingjing Hu, Yu Liu, Jian Ruan, Xianghua Ye, Yi Zheng, Jia Yao, Zhen Zhai, Shuqian Wang, Si Yang, Ying Wu, Na Li, Peng Xu & hellip; Tags: Research Source Type: research

CDK7 inhibitor THZ1 enhances antiPD-1 therapy efficacy via the p38 α/MYC/PD-L1 signaling in non-small cell lung cancer
The cyclin-dependent kinase 7 (CDK7) subunit of TFIIH regulates RNA polymerase-II-based transcription and promotes tumor progression. However, the mechanisms involved in CDK7-mediated immune evasion are unclea... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 20, 2020 Category: Hematology Authors: Jian Wang, Ruiguang Zhang, Zhenyu Lin, Sheng Zhang, Yaobing Chen, Jing Tang, Jiaxin Hong, Xiaoshu Zhou, Yan Zong, Yingzhuo Xu, Rui Meng, Shuangbing Xu, Li Liu, Tao Zhang, Kunyu Yang, Xiaorong Dong & hellip; Tags: Research Source Type: research

DT2216 —a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas
Patients with advanced T cell lymphomas (TCLs) have limited therapeutic options and poor outcomes in part because their TCLs evade apoptosis through upregulation of anti-apoptotic Bcl-2 proteins. Subsets of TC... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 16, 2020 Category: Hematology Authors: Yonghan He, Raphael Koch, Vivekananda Budamagunta, Peiyi Zhang, Xuan Zhang, Sajid Khan, Dinesh Thummuri, Yuma T. Ortiz, Xin Zhang, Dongwen Lv, Janet S. Wiegand, Wen Li, Adam C. Palmer, Guangrong Zheng, David M. Weinstock and Daohong Zhou Tags: Research Source Type: research

Role of CD47 in Hematological Malignancies
CD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by nearly all cells of the body. It plays an integral role in various immune responses as well as autoimmunity, by sending... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 16, 2020 Category: Hematology Authors: Entsar Eladl, Rosemarie Tremblay-LeMay, Nasrin Rastgoo, Rumina Musani, Wenming Chen, Aijun Liu and Hong Chang Tags: Review Source Type: research

Modeling neoplastic disease with spheroids and organoids
Cancer is a complex disease in which both genetic defects and microenvironmental components contribute to the development, progression, and metastasization of disease, representing major hurdles in the identif... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 16, 2020 Category: Hematology Authors: Michele Zanoni, Michela Cortesi, Alice Zamagni, Chiara Arienti, Sara Pignatta and Anna Tesei Tags: Review Source Type: research

Survival outcomes and clinical benefit in patients with acute myeloid leukemia treated with glasdegib and low-dose cytarabine according to response to therapy
The phase 2 BRIGHT AML 1003 trial evaluated efficacy and safety of glasdegib + low-dose cytarabine (LDAC) in patients with acute myeloid leukemia ineligible for intensive chemotherapy. The multicenter, open-la... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 14, 2020 Category: Hematology Authors: Jorge E. Cortes, Florian H. Heidel, Walter Fiedler, B. Douglas Smith, Tadeusz Robak, Pau Montesinos, Anna Candoni, Brian Leber, Mikkael A. Sekeres, Daniel A. Pollyea, Roxanne Ferdinand, Weidong Wendy Ma, Thomas O ’Brien, Ashleigh O’Connell, Geoffrey C Tags: Research Source Type: research

Beyond thrombosis: the impact of tissue factor signaling in cancer
Tissue factor (TF) is the primary initiator of the coagulation cascade, though its effects extend well beyond hemostasis. When TF binds to Factor VII, the resulting TF:FVIIa complex can proteolytically cleave ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 14, 2020 Category: Hematology Authors: Dusten Unruh and Craig Horbinski Tags: Review Source Type: research

A tertiary center experience of multiple myeloma patients with COVID-19: lessons learned and the path forward
The COVID-19 pandemic, caused by SARS-CoV-2 virus, has resulted in over 100,000 deaths in the USA. Our institution has treated over 2000 COVID-19 patients during the pandemic in New York City. The pandemic dir... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 14, 2020 Category: Hematology Authors: Bo Wang, Oliver Van Oekelen, Tarek H. Mouhieddine, Diane Marie Del Valle, Joshua Richter, Hearn Jay Cho, Shambavi Richard, Ajai Chari, Sacha Gnjatic, Miriam Merad, Sundar Jagannath, Samir Parekh and Deepu Madduri Tags: Research Source Type: research

High mobility group box 1 (HMGB1): a pivotal regulator of hematopoietic malignancies
High mobility group box 1 (HMGB1) is a nonhistone chromatin-associated protein that has been widely reported to play a pivotal role in the pathogenesis of hematopoietic malignancies. As a representative damage... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 13, 2020 Category: Hematology Authors: Shunling Yuan, Zhaoping Liu, Zhenru Xu, Jing Liu and Ji Zhang Tags: Review Source Type: research

Bovine pestivirus is a new alternative virus for multiple myeloma oncolytic virotherapy
In this study, we investigated... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 11, 2020 Category: Hematology Authors: Valentina Marchica, Valentina Franceschi, Rosanna Vescovini, Paola Storti, Emanuela Vicario, Denise Toscani, Alessia Zorzoli, Irma Airoldi, Benedetta Dalla Palma, Nicoletta Campanini, Eugenia Martella, Cristina Mancini, Federica Costa, Gaetano Donofrio an Tags: Research Source Type: research

RNA-binding proteins in tumor progression
RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and important biological functions. They are critical to maintain the transcriptome through post-transcriptionally controlling t... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 11, 2020 Category: Hematology Authors: Hai Qin, Haiwei Ni, Yichen Liu, Yaqin Yuan, Tao Xi, Xiaoman Li and Lufeng Zheng Tags: Review Source Type: research

Constructing an automatic diagnosis and severity-classification model for acromegaly using facial photographs by deep learning
Due to acromegaly ’s insidious onset and slow progression, its diagnosis is usually delayed, thus causing severe complications and treatment difficulty. A convenient screening method is imperative. Based on our... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 3, 2020 Category: Hematology Authors: Yanguo Kong, Xiangyi Kong, Cheng He, Changsong Liu, Liting Wang, Lijuan Su, Jun Gao, Qi Guo and Ran Cheng Tags: Letter to the Editor Source Type: research

Post-transplant cyclophosphamide versus antithymocyte globulin in patients with acute myeloid leukemia in first complete remission undergoing allogeneic stem cell transplantation from 10/10 HLA-matched unrelated donors
Graft-versus-host disease (GVHD) remains a major contributor to mortality and morbidity after allogeneic stem-cell transplantation (allo-HSCT). The updated recommendations suggest that rabbit antithymocyte glo... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 3, 2020 Category: Hematology Authors: Eolia Brissot, Myriam Labopin, Ian Moiseev, J. J. Cornelissen, Ellen Meijer, Gwendolyn Van Gorkom, Montserrat Rovira, Fabio Ciceri, Laimonas Griskevicius, Didier Blaise, Edouard Forcade, Martin Mistrik, Stephan Mielke, Claude Eric Bulabois, Riitta Niittyv Tags: Research Source Type: research

Autoantibody signature in hepatocellular carcinoma using seromics
Alpha-fetoprotein (AFP) is a widely used biomarker for hepatocellular carcinoma (HCC) early detection. However, low sensitivity and false negativity of AFP raise the requirement of more effective early diagnos... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 2, 2020 Category: Hematology Authors: Shu Zhang, Yuming Liu, Jing Chen, Hong Shu, Siyun Shen, Yin Li, Xinyuan Lu, Xinyi Cao, Liangqing Dong, Jieyi Shi, Ya Cao, Xiaoying Wang, Jian Zhou, Yinkun Liu, Lei Chen, Jia Fan & hellip; Tags: Research Source Type: research

Recent advances in CAR-T cell engineering
Chimeric antigen receptor T (CAR-T) cell therapy is regarded as an effective solution for relapsed or refractory tumors, particularly for hematological malignancies. Although the initially approved anti-CD19 C... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 2, 2020 Category: Hematology Authors: Ruihao Huang, Xiaoping Li, Yundi He, Wen Zhu, Lei Gao, Yao Liu, Li Gao, Qin Wen, Jiang F. Zhong, Cheng Zhang and Xi Zhang Tags: Review Source Type: research

VISTA: an immune regulatory protein checking tumor and immune cells in cancer immunotherapy
VISTA (V-domain immunoglobulin suppressor of T cell activation) is a well-established immune regulatory receptor. However, pre-clinical investigations indicated more complicated influences of VISTA on cancer i... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 29, 2020 Category: Hematology Authors: Xing Huang, Xiaozhen Zhang, Enliang Li, Gang Zhang, Xun Wang, Tianyu Tang, Xueli Bai and Tingbo Liang Tags: Review Source Type: research

Oncolytic viruses for cancer immunotherapy
In this review, we discuss the use of oncolytic viruses in cancer immunotherapy treatments in general, with a particular focus on adenoviruses. These serve as a model to elucidate how versatile viruses are, an... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 29, 2020 Category: Hematology Authors: Otto Hemminki, Jo ão Manuel dos Santos and Akseli Hemminki Tags: Review Source Type: research

cGAS-STING, an important pathway in cancer immunotherapy
Cytosolic DNA sensing, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, is an important novel role in the immune system. Multiple STING agonists were developed for cancer therap... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 22, 2020 Category: Hematology Authors: Minlin Jiang, Peixin Chen, Lei Wang, Wei Li, Bin Chen, Yu Liu, Hao Wang, Sha Zhao, Lingyun Ye, Yayi He and Caicun Zhou Tags: Review Source Type: research

Measurable residual disease in multiple myeloma: ready for clinical practice?
The landscape of multiple myeloma (MM) has changed considerably in the past two decades regarding new treatments, insight into disease biology and innovation in the techniques available to assess measurable re... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 22, 2020 Category: Hematology Authors: Leire Burgos, Noemi Puig, Maria-Teresa Cedena, Mar ía-Victoria Mateos, Juan José Lahuerta, Bruno Paiva and Jesús F. San-Miguel Tags: Review Source Type: research

Combination therapy of BCR-ABL-positive B cell acute lymphoblastic leukemia by tyrosine kinase inhibitor dasatinib and c-JUN N-terminal kinase inhibition
The Philadelphia chromosome (Ph), which leads to the creation and expression of the fusion gene product BCR-ABL, underlines the pathogenesis of chronic myelogenous leukemia (CML) and a fraction of adult and pe... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 18, 2020 Category: Hematology Authors: Xinhua Xiao, Ping Liu, Donghe Li, Zhizhou Xia, Peihong Wang, Xiuli Zhang, Mingzhu Liu, Lujian Liao, Bo Jiao and Ruibao Ren Tags: Research Source Type: research

The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia
Mixed-lineage leukemia (MLL) gene rearrangements trigger aberrant epigenetic modification and gene expression in hematopoietic stem and progenitor cells, which generates one of the most aggressive subtypes of leu... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 17, 2020 Category: Hematology Authors: Wen-Tao Wang, Tian-Qi Chen, Zhan-Cheng Zeng, Qi Pan, Wei Huang, Cai Han, Ke Fang, Lin-Yu Sun, Qian-Qian Yang, Dan Wang, Xue-Qun Luo, Yu-Meng Sun and Yue-Qin Chen Tags: Research Source Type: research