Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development
Anlotinib is a new, orally administered tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor rece... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 19, 2018 Category: Hematology Authors: Guoshuang Shen, Fangchao Zheng, Dengfeng Ren, Feng Du, Qiuxia Dong, Ziyi Wang, Fuxing Zhao, Raees Ahmad and Jiuda Zhao Tags: Review Source Type: research

JAG1 overexpression contributes to Notch1 signaling and the migration of HTLV-1-transformed ATL cells
HTLV-1 is a retrovirus that infects over 20 million people worldwide and is responsible for the hematopoietic malignancy adult T cell leukemia (ATL). We previously demonstrated that Notch is constitutively act... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 19, 2018 Category: Hematology Authors: Marcia Bellon, Ramona Moles, Hassiba Chaib-Mezrag, Joanna Pancewicz and Christophe Nicot Tags: Research Source Type: research

Long non-coding RNAs in esophageal cancer: molecular mechanisms, functions, and potential applications
Esophageal cancer (EC) is the sixth leading cause of cancer-related death worldwide. The lack of early diagnostic biomarkers and effective prognostic indicators for metastasis and recurrence has resulted in th... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 17, 2018 Category: Hematology Authors: Min Su, Yuhang Xiao, Junliang Ma, Deliang Cao, Yong Zhou, Hui Wang, Qianjin Liao and Wenxiang Wang Tags: Review Source Type: research

Novel antibodies against GPIb α inhibit pulmonary metastasis by affecting vWF-GPIbα interaction
Platelet glycoprotein Ib α (GPIbα) extracellular domain, which is part of the receptor complex GPIb-IX-V, plays an important role in tumor metastasis. However, the mechanism through which GPIbα participates in ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 17, 2018 Category: Hematology Authors: Yingxue Qi, Wenchun Chen, Xinyu Liang, Ke Xu, Xiangyu Gu, Fengying Wu, Xuemei Fan, Shengxiang Ren, Junling Liu, Jun Zhang, Renhao Li, Jianwen Liu and Xin Liang Tags: Research Source Type: research

Organoid technology and applications in cancer research
During the past decade, the three-dimensional organoid technology has sprung up and become more and more popular among researchers. Organoids are the miniatures of in vivo tissues and organs, and faithfully re... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 15, 2018 Category: Hematology Authors: Hanxiao Xu, Xiaodong Lyu, Ming Yi, Weiheng Zhao, Yongping Song and Kongming Wu Tags: Review Source Type: research

Overexpression of CLC-3 is regulated by XRCC5 and is a poor prognostic biomarker for gastric cancer
Recently, many potential prognostic biomarkers for gastric cancer (GC) have been identified, but the prognosis of advanced GC patients remains poor. Chloride channels are promising cancer biomarkers, and their... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 14, 2018 Category: Hematology Authors: Zhuoyu Gu, Yixin Li, Xiaoya Yang, Meisheng Yu, Zhanru Chen, Chan Zhao, Lixin Chen and Liwei Wang Tags: Research Source Type: research

Selective killing of circulating tumor cells prevents metastasis and extends survival
Distant metastasis is initiated by circulating tumor cells (CTCs), which are considered to be a determining factor for the degree of metastasis and the survival of cancer patients. Although CTC-based diagnosti... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 10, 2018 Category: Hematology Authors: Yi Rang Kim, Jung Ki Yoo, Chang Wook Jeong and Jin Woo Choi Tags: Letter to the Editor Source Type: research

The lncRNA NEAT1 activates Wnt/ β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5
The long noncoding RNA nuclear-enriched abundant transcript 1 (NEAT1) has been reported to be overexpressed in colorectal cancer (CRC). However, its underlying mechanisms in the progression of CRC have not bee... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 5, 2018 Category: Hematology Authors: Meng Zhang, Weiwei Weng, Qiongyan Zhang, Yong Wu, Shujuan Ni, Cong Tan, Midie Xu, Hui Sun, Chenchen Liu, Ping Wei and Xiang Du Tags: Research Source Type: research

Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA
Mantle cell lymphoma (MCL) is an aggressive B-non-Hodgkin lymphoma with generally poor outcome. MCL is characterized by an aberrantly high cyclin D1-driven CDK4 activity. New molecular targeted therapies such ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 4, 2018 Category: Hematology Authors: Simon Heine, Markus Kleih, Neus Gim énez, Kathrin Böpple, German Ott, Dolors Colomer, Walter E. Aulitzky, Heiko van der Kuip and Elisabeth Silkenstedt Tags: Research Source Type: research

Histone deacetylase 6 in cancer
Histone acetylation and deacetylation are important epigenetic mechanisms that regulate gene expression and transcription. Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family that not only part... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - September 3, 2018 Category: Hematology Authors: Ting Li, Chao Zhang, Shafat Hassan, Xinyue Liu, Fengju Song, Kexin Chen, Wei Zhang and Jilong Yang Tags: Review Source Type: research

Haploidentical transplantation is associated with better overall survival when compared to single cord blood transplantation: an EBMT-Eurocord study of acute leukemia patients conditioned with thiotepa, busulfan, and fludarabine
Thiotepa-busulfan-fludarabine (TBF) is a widely used conditioning regimen in single umbilical cord blood transplantation (SUCBT). More recently, it was introduced in the setting of non-T cell depleted haploide... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 30, 2018 Category: Hematology Authors: Federica Giannotti, Myriam Labopin, Roni Shouval, Jaime Sanz, William Arcese, Emanuele Angelucci, Jorge Sierra, Josep-Maria Ribera Santasusana, Stella Santarone, Bruno Benedetto, Alessandro Rambaldi, Riccardo Saccardi, Didier Blaise, Michele Angelo Carell Tags: Research Source Type: research

Mouse avatar models of esophageal squamous cell carcinoma proved the potential for EGFR-TKI afatinib and uncovered Src family kinases involved in acquired resistance
No approved targeted agents are available for esophageal squamous cell carcinoma (ESCC). Informative genomic analysis and mouse patient-derived xenografts (PDX) also called mouse avatar can greatly expedite dr... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 29, 2018 Category: Hematology Authors: Zhentao Liu, Zuhua Chen, Jingyuan Wang, Mengqi Zhang, Zhongwu Li, Shubin Wang, Bin Dong, Cheng Zhang, Jing Gao and Lin Shen Tags: Research Source Type: research

The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models
The CNOT3 protein is a subunit of the CCR4-NOT complex, which is involved in mRNA degradation. We recently identified CNOT3 loss-of-function mutations in patients with T-cell acute lymphoblastic leukemia (T-ALL). (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 25, 2018 Category: Hematology Authors: Carmen Vicente, Rocco Stirparo, Sofie Demeyer, Charles E. de Bock, Olga Gielen, Mardelle Atkins, Jiekun Yan, Georg Halder, Bassem A. Hassan and Jan Cools Tags: Research Source Type: research

The roles of metallothioneins in carcinogenesis
Metallothioneins (MTs) are small cysteine-rich proteins that play important roles in metal homeostasis and protection against heavy metal toxicity, DNA damage, and oxidative stress. In humans, MTs have four ma... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 23, 2018 Category: Hematology Authors: Manfei Si and Jinghe Lang Tags: Review Source Type: research

Emerging roles of long non-coding RNAs in tumor metabolism
Compared with normal cells, tumor cells display distinct metabolic characteristics. Long non-coding RNAs (lncRNAs), a large class of regulatory RNA molecules with limited or no protein-coding capacity, play ke... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 22, 2018 Category: Hematology Authors: Hui Sun, Zhaohui Huang, Weiqi Sheng and Mi-die Xu Tags: Review Source Type: research

Simple deep sequencing-based post-remission MRD surveillance predicts clinical relapse in B-ALL
Next-generation sequencing (NGS) of the rearranged immunoglobulin heavy-chain gene has emerged as a highly sensitive method to detect minimal residual disease (MRD) in B acute lymphoblastic leukemia/lymphoma (... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 22, 2018 Category: Hematology Authors: Shuhua Cheng, Giorgio Inghirami, Shuo Cheng and Wayne Tam Tags: Research Source Type: research

Successful treatment of secondary poor graft function post allogeneic hematopoietic stem cell transplantation with eltrombopag
Poor graft function (PGF) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Current treatment strategies include the use of growth factors, CD34+-selected st... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 16, 2018 Category: Hematology Authors: Cen Tang, Feng Chen, Danqing Kong, Qinfen Ma, Haiping Dai, Jia Yin, Zheng Li, Jia Chen, Xiaming Zhu, Xinliang Mao, Depei Wu and Xiaowen Tang Tags: Letter to the Editor Source Type: research

Abscopal effect of radiotherapy combined with immune checkpoint inhibitors
Radiotherapy (RT) is used routinely as a standard treatment for more than 50% of patients with malignant tumors. The abscopal effect induced by local RT, which is considered as a systemic anti-tumor immune res... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 16, 2018 Category: Hematology Authors: Yang Liu, Yinping Dong, Li Kong, Fang Shi, Hui Zhu and Jinming Yu Tags: Review Source Type: research

Recombination of a dual-CAR-modified T lymphocyte to accurately eliminate pancreatic malignancy
The therapeutic application of T cells endowing with chimeric antigen receptors (CARs) is faced with “on-target, off-tumor” toxicity against solid tumors, particularly in the treatment of the pancreatic cancer... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 13, 2018 Category: Hematology Authors: Erhao Zhang, Peiwei Yang, Jieyi Gu, Heming Wu, Xiaowei Chi, Chen Liu, Ying Wang, Jianpeng Xue, Weiyan Qi, Qingbo Sun, Shengnan Zhang, Jialiang Hu and Hanmei Xu Tags: Research Source Type: research

Evaluation of an alternative ruxolitinib dosing regimen in patients with myelofibrosis: an open-label phase 2 study
Ruxolitinib improves splenomegaly and symptoms in patients with intermediate-2 or high-risk myelofibrosis; however, nearly half develop grade 3/4 anemia and/or thrombocytopenia, necessitating dose reductions a... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 7, 2018 Category: Hematology Authors: Moshe Talpaz, Susan Erickson-Viitanen, Kevin Hou, Solomon Hamburg and Maria R. Baer Tags: Research Source Type: research

Targeting the IDO1 pathway in cancer: from bench to bedside
Indoleamine 2, 3-dioxygenases (IDO1 and IDO2) and tryptophan 2, 3-dioxygenase (TDO) are tryptophan catabolic enzymes that catalyze the conversion of tryptophan into kynurenine. The depletion of tryptophan and ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 2, 2018 Category: Hematology Authors: Ming Liu, Xu Wang, Lei Wang, Xiaodong Ma, Zhaojian Gong, Shanshan Zhang and Yong Li Tags: Review Source Type: research

Targeting WEE1 to enhance conventional therapies for acute lymphoblastic leukemia
Despite the recent progress that has been made in the understanding and treatment of acute lymphoblastic leukemia (ALL), the outcome is still dismal in adult ALL cases. Several studies in solid tumors identifi... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - August 1, 2018 Category: Hematology Authors: Andrea Ghelli Luserna Di Ror à, Neil Beeharry, Enrica Imbrogno, Anna Ferrari, Valentina Robustelli, Simona Righi, Elena Sabattini, Maria Vittoria Verga Falzacappa, Chiara Ronchini, Nicoletta Testoni, Carmen Baldazzi, Cristina Papayannidis, Maria Chiara A Tags: Research Source Type: research

Function and clinical significance of circRNAs in solid tumors
Circular RNA (circRNA) is a new type of endogenous non-coding RNAs (ncRNAs). circRNA regulates gene expression in many biological processes, and it also participates in the initiation and development of variou... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 31, 2018 Category: Hematology Authors: Yiting Geng, Jingting Jiang and Changping Wu Tags: Review Source Type: research

Immune cell subset differentiation and tissue inflammation
Immune cells were traditionally considered as major pro-inflammatory contributors. Recent advances in molecular immunology prove that immune cell lineages are composed of different subsets capable of a vast ar... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 31, 2018 Category: Hematology Authors: Pu Fang, Xinyuan Li, Jin Dai, Lauren Cole, Javier Andres Camacho, Yuling Zhang, Yong Ji, Jingfeng Wang, Xiao-Feng Yang and Hong Wang Tags: Review Source Type: research

Frequency and clinical impact of CDKN2A/ARF/CDKN2B gene deletions as assessed by in-depth genetic analyses in adult T cell acute lymphoblastic leukemia
Recurrent deletions of the CDKN2A/ARF/CDKN2B genes encoded at chromosome 9p21 have been described in both pediatric and adult acute lymphoblastic leukemia (ALL), but their prognostic value remains controversial, ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 24, 2018 Category: Hematology Authors: E. Genesc à, A. Lazarenkov, M. Morgades, G. Berbis, N. Ruíz-Xivillé, P. Gómez-Marzo, J. Ribera, J. Juncà, A. González-Pérez, S. Mercadal, R. Guardia, M. T. Artola, M. J. Moreno, J. Martínez-López, L. Zamora, P. Barba & hellip; Tags: Letter to the Editor Source Type: research

Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy
Ubiquitination is a basic post-translational modification for cellular homeostasis, and members of the conjugating enzyme (E2) family are the key components of the ubiquitin –proteasome system. However, the rol... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 17, 2018 Category: Hematology Authors: Tong Shen, Ling-Dong Cai, Yu-Hong Liu, Shi Li, Wen-Juan Gan, Xiu-Ming Li, Jing-Ru Wang, Peng-Da Guo, Qun Zhou, Xing-Xing Lu, Li-Na Sun and Jian-Ming Li Tags: Research Source Type: research

Correction to: Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways
The original article [1] contained minor typesetting errors affecting the following authors: Ziang Jeff Gao, Xiao Zhen Zhou, and Kun Ping Lu. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 11, 2018 Category: Hematology Authors: Xiaolan Lian, Yu-Min Lin, Shingo Kozono, Megan K. Herbert, Xin Li, Xiaohong Yuan, Jiangrui Guo, Yafei Guo, Min Tang, Jia Lin, Yiping Huang, Bixin Wang, Chenxi Qiu, Cheng-Yu Tsai, Jane Xie, Ziang Jeff Gao & hellip; Tags: Correction Source Type: research

Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia
In this study, w... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 9, 2018 Category: Hematology Authors: Ling Xu, Danlin Yao, Jiaxiong Tan, Zifan He, Zhi Yu, Jie Chen, Gengxin Luo, Chunli Wang, Fenfang Zhou, Xianfeng Zha, Shaohua Chen and Yangqiu Li Tags: Letter to the Editor Source Type: research

Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells
Triple-negative breast cancer (TNBC) is an aggressive disease that currently lacks effective targeted therapy. NKG2D ligands (NKG2DLs) are expressed on various tumor types and immunosuppressive cells within tu... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 6, 2018 Category: Hematology Authors: Yali Han, Wei Xie, De-Gang Song and Daniel J. Powell Jr Tags: Research Source Type: research

T cell senescence and CAR-T cell exhaustion in hematological malignancies
T cell senescence has been recognized to play an immunosuppressive role in the aging population and cancer patients. Strategies dedicated to preventing or reversing replicative and premature T cell senescence ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 4, 2018 Category: Hematology Authors: Dimitri Kasakovski, Ling Xu and Yangqiu Li Tags: Review Source Type: research

Correction to: miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy
The original article [1] contains a spelling error in the authorship; the authors would like to note the correct spelling of the second author, Jiajia Xi. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 3, 2018 Category: Hematology Authors: Qian Huang, Jiajia Xi, Lei Wang, Xu Wang, Xiaodong Ma, Qipan Deng, Yong Lu, Munish Kumar, Zhiyuan Zhou, Ling Li, Zhaoyang Zeng, Ken H. Young, Qing Yi, Mingzhi Zhang and Yong Li Tags: Correction Source Type: research

Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression
Colorectal cancer (CRC) arises in a multistep molecular network process, which is from either discrete genetic perturbation or epigenetic dysregulation. The long non-coding RNAs (lncRNAs), emerging as key mole... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - July 3, 2018 Category: Hematology Authors: Yang Li, Changqian Zeng, Jialei Hu, Yue Pan, Yujia Shan, Bing Liu and Li Jia Tags: Research Source Type: research

Multi-center phase II trial of bortezomib and rituximab maintenance combination therapy in patients with mantle cell lymphoma after consolidative autologous stem cell transplantation
Mantle cell lymphoma (MCL) is an aggressive and incurable lymphoma. Standard of care for younger patients with MCL is induction chemotherapy followed by autologous stem cell transplantation (auto-HCT). Rituxim... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 28, 2018 Category: Hematology Authors: Robert W. Chen, Joycelynne M. Palmer, Sarah Tomassetti, Leslie L. Popplewell, Jessica Alluin, Pritsana Chomchan, Auayporn P. Nademanee, Tanya Siddiqi, Ni-Chun Tsai, Lu Chen, Fay Zuo, Rosemarie Abary, Ji-lian Cai, Alex F. Herrera, John J. Rossi, Steven T. Tags: Research Source Type: research

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer
The insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) plays essential roles in embryogenesis and carcinogenesis. IGF2BP1 serves as a post-transcriptional fine-tuner regulating the expression of som... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 28, 2018 Category: Hematology Authors: Xinwei Huang, Hong Zhang, Xiaoran Guo, Zongxin Zhu, Haibo Cai and Xiangyang Kong Tags: Review Source Type: research

Targeting ERBB2 mutations in solid tumors: biological and clinical implications
Preclinical data have shown that ERBB2 activating mutations are responsive to HER2 tyrosine kinase inhibitors. The aim of this study is to characterize the landscape of ERBB2 mutations in solid tumors and the ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 25, 2018 Category: Hematology Authors: Sophie Cousin, Emmanuel Khalifa, Amandine Crombe, Yech ’an Laizet, Carlo Lucchesi, Maud Toulmonde, Sylvestre Le Moulec, Céline Auzanneau, Isabelle Soubeyran and Antoine Italiano Tags: Letter to the Editor Source Type: research

Combating head and neck cancer metastases by targeting Src using multifunctional nanoparticle-based saracatinib
Inhibition of metastasis of head and neck squamous cell carcinoma (HNSCC) is one of the most important challenges in cancer treatment. Src, a non-receptor tyrosine kinase, has been implicated as a key promoter... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 20, 2018 Category: Hematology Authors: Liwei Lang, Chloe Shay, Yuanping Xiong, Parth Thakkar, Ron Chemmalakuzhy, Xuli Wang and Yong Teng Tags: Research Source Type: research

Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy
Bcr-Abl inhibitors paved the way of targeted therapy epoch. Imatinib was the first tyrosine kinase inhibitor to be discovered with high specificity for Bcr-Abl protein resulting from t(9, 22)-derived Philadelp... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 20, 2018 Category: Hematology Authors: Federico Rossari, Filippo Minutolo and Enrico Orciuolo Tags: Review Source Type: research

NF- κB signaling and its relevance to the treatment of mantle cell lymphoma
Mantle cell lymphoma is an aggressive subtype of non-Hodgkin B cell lymphoma that is characterized by a poor prognosis determined by Ki67 and Mantle Cell International Prognostic Index scores, but it is becomi... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 15, 2018 Category: Hematology Authors: Swathi Balaji, Makhdum Ahmed, Elizabeth Lorence, Fangfang Yan, Krystle Nomie and Michael Wang Tags: Review Source Type: research

Exosomes released by hepatocarcinoma cells endow adipocytes with tumor-promoting properties
The initiation and progression of hepatocellular carcinoma (HCC) are largely dependent on its local microenvironment. Adipocytes are an important component of hepatic microenvironment in nonalcoholic fatty liv... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 14, 2018 Category: Hematology Authors: Shihua Wang, Meiqian Xu, Xiaoxia Li, Xiaodong Su, Xian Xiao, Armand Keating and Robert Chunhua Zhao Tags: Research Source Type: research

Correction to: Grading of cytokine release syndrome associated with the CAR T cell therapy tisagenlecleucel
The original article contains several small errors. The errors& concurrent corrections are listed below [1]: (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 13, 2018 Category: Hematology Authors: D. Porter, N. Frey, P. A. Wood, Y. Weng and S. A. Grupp Tags: Correction Source Type: research

Predictors of atrial fibrillation in ibrutinib-treated CLL patients: a prospective study
Ibrutinib is an oral irreversible inhibitor of Bruton ’s tyrosine kinase, indicated for the treatment of chronic lymphocytic leukaemia. The drug is generally well tolerated; however, not infrequent side effects... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 11, 2018 Category: Hematology Authors: Gianluigi Reda, Bruno Fattizzo, Ramona Cassin, Veronica Mattiello, Tatiana Tonella, Diana Giannarelli, Ferdinando Massari and Agostino Cortelezzi Tags: Letter to the Editor Source Type: research

Overcoming endocrine resistance in metastatic hormone receptor-positive breast cancer
Endocrine therapy has historically formed the basis of treatment of metastatic hormone receptor-positive breast cancer. The development of endocrine resistance has led to the development of newer endocrine dru... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 11, 2018 Category: Hematology Authors: Anishka D ’Souza, Darcy Spicer and Janice Lu Tags: Review Source Type: research

Basket trial of TRK inhibitors demonstrates efficacy in TRK fusion-positive cancers
Unlike many conventional cancers with preferential patterns of oncogenic genetic alterations, TRK fusions resulting from NTRK1/2/3 genetic alterations drive oncogenic transformations in more than 20 different ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 7, 2018 Category: Hematology Authors: Yu Chen and Ping Chi Tags: Research highlight Source Type: research

MET alterations detected in blood-derived circulating tumor DNA correlate with bone metastases and poor prognosis
We analyzed clinical associations of MET alterations in the plasma of patients with diverse malignancies. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 4, 2018 Category: Hematology Authors: Sadakatsu Ikeda, Maria Schwaederle, Mandakini Mohindra, Denis L. Fontes Jardim and Razelle Kurzrock Tags: Research Source Type: research

A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy
Despite the overwhelming number of investigations on AKT, little is known about lncRNA on AKT regulation, especially in GBM cells. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - June 4, 2018 Category: Hematology Authors: Changhong Liu, Yan Zhang, Xiaoling She, Li Fan, Peiyao Li, Jianbo Feng, Haijuan Fu, Qing Liu, Qiang Liu, Chunhua Zhao, Yingnan Sun and Minghua Wu Tags: Research Source Type: research

The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells
Epithelial-to-mesenchymal transition (EMT) has, in recent years, emerged as an important tumor cell behavior associated with high metastatic potential and drug resistance. Interestingly, protein SUMOylation an... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 31, 2018 Category: Hematology Authors: Nithila A. Joseph, Shiow-Her Chiou, Zoe Lung, Cheng-Lin Yang, Tze-Yi Lin, Hui-Wen Chang, H. Sunny Sun, Sachin Kumar Gupta, Laising Yen, Shulhn-Der Wang and Kuan-Chih Chow Tags: Research Source Type: research

Treating hematological malignancies with drugs inhibiting ribosome biogenesis: when and why
It is well known that chemotherapy can cure only some cancers in advanced stage, mostly those with an intact p53 pathway. Hematological cancers such as lymphoma and certain forms of leukemia are paradigmatic e... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 31, 2018 Category: Hematology Authors: Enrico Derenzini, Alessandra Rossi and Davide Trer é Tags: Review Source Type: research

Randomized, phase I/II study of gemcitabine plus IGF-1R antagonist (MK-0646) versus gemcitabine plus erlotinib with and without MK-0646 for advanced pancreatic adenocarcinoma
Binding of insulin-like growth factor-I (IGF-1) to its receptor (IGF-1R) initiates downstream signals that activate PI3K/Akt/mTOR and MEK/Erk pathways, which stimulate cancer cell proliferation and induce drug... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 30, 2018 Category: Hematology Authors: Reham Abdel-Wahab, Gauri R. Varadhachary, Priya R. Bhosale, Xuemei Wang, David R. Fogelman, Rachna T. Shroff, Michael J. Overman, Robert A. Wolff and Milind Javle Tags: Research Source Type: research

STARD13-correlated ceRNA network-directed inhibition on YAP/TAZ activity suppresses stemness of breast cancer via co-regulating Hippo and Rho-GTPase/F-actin signaling
Targeting cancer stem cells is critical for suppressing cancer progression and recurrence. Finding novel markers or related pathways could help eradicate or diagnose cancer in clinic. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 30, 2018 Category: Hematology Authors: Lufeng Zheng, Chenxi Xiang, Xiaoman Li, Qianqian Guo, Lanlan Gao, Haiwei Ni, Yufeng Xia and Tao Xi Tags: Research Source Type: research

Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways
The increasing genomic complexity of acute myeloid leukemia (AML), the most common form of acute leukemia, poses a major challenge to its therapy. To identify potent therapeutic targets with the ability to blo... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 30, 2018 Category: Hematology Authors: Xiaolan Lian, Yu-Min Lin, Shingo Kozono, Megan K. Herbert, Xin Li, Xiaohong Yuan, Jiangrui Guo, Yafei Guo, Min Tang, Jia Lin, Yiping Huang, Bixin Wang, Chenxi Qiu, Cheng-Yu Tsai, Jane Xie, Ziang Jeff Cao & hellip; Tags: Research Source Type: research