Determinants of omalizumab dose-related efficacy in oral immunotherapy: evidence from a cohort of 181 patients.
Capsule summaryUsing a large cohort of food allergic patients undergoing oral immunotherapy, the dose-related efficacy of omalizumab is shown to be dependent on its dosage per weight and independent of total IgE levels. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 24, 2020 Category: Allergy & Immunology Authors: Pauline Azzano, Maxime Paquin, Alexandra Langlois, Charles Morin, Guy Parizeault, Jonathan Lacombe-Barrios, Kathryn Samaan, Fran çois Graham, Louis Paradis, Anne Des Roches, Philippe Begin Source Type: research

Coronavirus Disease 2019 in patients with inborn errors of immunity: an international study
Capsule Summary: Clinical data from 94 SARS-CoV-2-infected individuals affected by inborn errors of immunity provide initial insights into the requirements and redundancies of immune pathways in host defense against and severity of SARS-CoV-2 infection. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 24, 2020 Category: Allergy & Immunology Authors: Isabelle Meyts, Giorgia Bucciol, Isabella Quinti, B énédicte Neven, Alain Fischer, Elena Seoane, Eduardo Lopez-Granados, Carla Gianelli, Angel Robles-Marhuenda, Pierre-Yves Jeandel, Catherine Paillard, Vijay G. Sankaran, Yesim Yilmaz Demirdag, Vassilios Source Type: research

Combined immunodeficiency caused by a novel homozygous NFKB1 mutation
We describe a homozygous mutation in NFKB1 (G960R) that interrupts T and B cell maturation and is associated with severe viral, microbial and fungal infections during infancy. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 24, 2020 Category: Allergy & Immunology Authors: Amarilla B. Mandola, Nigel Sharfe, Zahra Nagdi, Harjit Dadi, Linda Vong, Daniele Merico, Bo Ngan, Brenda Reid, Chaim M. Roifman, CM Source Type: research

Timing of exposure to environmental adjuvants is critical to mitigate peanut allergy
Capsule summary:Toll-like receptor ligands in indoor dust act as environmental adjuvants to promote sensitization to inhaled peanut in mice. The timing of exposure to environmental adjuvants relative to peanut is a determinant of peanut allergy development. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 23, 2020 Category: Allergy & Immunology Authors: Johanna M. Smeekens, Robert M. Immormino, Michael D. Kulis, Timothy P. Moran Source Type: research

Compartmental immunophenotyping in COVID-19 ARDS: a case series
Capsule summary: The lungs of patients with COVID-19 ARDS are heavily inflamed and conceal a depleted and hyperactivated T cell population; these distinct immunological changes likely contribute to the severe lung injury observed in this condition. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 22, 2020 Category: Allergy & Immunology Authors: Andreas Ronit, Ronan M.G. Berg, Jakob T. Bay, Anna K. Haugaard, Magnus G. Ahlstr öm, Kristoffer S. Burgdorf, Henrik Ullum, Sara B. Rørvig, Klaus Tjelle, Nicolai B. Foss, Thomas Benfield, Hanne Vibeke Marquart, Ronni R. Plovsing Source Type: research

In lasting tribute: Charles E. Reed, March 13, 1922, to July 24, 2020
On July 24, 2020, Dr Charles E. Reed passed away at age 98 years. Dr Reed had a long and distinguished career; he was Professor of Medicine and Head of the Allergy programs at the University of Wisconsin Medical School (1961-1978), Madison, Wisconsin, and the Mayo Clinic (1978-1987), Rochester, Minnesota. During his career, Charlie provided key and effective leadership for our specialty. In 1971-1976, he was Co-Chairman of the first conjoint American Board of Allergy and Immunology (1971-1976). As the concept and initiation of a conjoint board was a new endeavor with many questions to consider, diplomacy, at many levels, w...
Source: Journal of Allergy and Clinical Immunology - September 22, 2020 Category: Allergy & Immunology Authors: Robert K. Bush, William W. Busse, James T. Li Tags: In lasting tribute Source Type: research

Immune Phenotypes in Individuals Positive for Antinuclear Antibodies: The Impact of Race and Ethnicity
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 21, 2020 Category: Allergy & Immunology Authors: David S. Pisetsky Source Type: research

Long-term outcomes for adults with chronic granulomatous disease in the united kingdom
Uncorrected CGD is associated with significant morbidity and mortality in adulthood, in particular due to inflammatory complications including life-limiting interstitial lung disease. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 20, 2020 Category: Allergy & Immunology Authors: Luiza C. Campos, Giulia Di Colo, Vruti Dattani, Helen Braggins, Dinakantha Kumararatne, Anthony P. Williams, Hana Alachkar, Stephen Jolles, Alexandra Battersby, Theresa Cole, Suzanne Elcombe, Kimberly C. Gilmour, David Goldblatt, Andrew R. Gennery, Jamand Source Type: research

It ’s that time of year - APRIL promotes humoral immunity in humans
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 20, 2020 Category: Allergy & Immunology Authors: Stuart G. Tangye Source Type: research

Elevated plasma sTIM-3 levels in severe Covid-19 patients
Capsule summaryOur study evaluating plasma leukocyte activation markers during hospitalization for COVID-19 disease indicate neutrophil and T cell activation, with signs of T cell exhaustion, associated with severe outcome. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 20, 2020 Category: Allergy & Immunology Authors: Thor Ueland, Lars Heggelund, Andreas Lind, Aleksander R. Holten, Kristian Tonby, Annika E. Michelsen, Synne Jenum, Marthe J. J ørgensen, Andreas Barratt-Due, Linda G. Skeie, Ingvild Nordøy, Mai Sasaki Aanensen Fraz, Else Quist-Paulsen E, Søren E. Pisch Source Type: research

Reply
We appreciate Li and Liu1 for their interests in and comments on our article.2 Although most patients with severe coronavirus disease 2019 (COVID-19) have a self-limited disease course, about 10% to 15% subsequently developed critical illness and experienced a high mortality.3,4 In our randomized controlled trial, we evaluated whether the use of ruxolitinib was safe and superior in shortening the time to recovery and in preventing severe COVID-19 from progression. Given below are our point-to-point responses to each of the comments. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 18, 2020 Category: Allergy & Immunology Authors: Yang Cao, Jia Wei, Gaoxiang Wang, Liting Chen, Hui Luo, Jianfeng Zhou Tags: Correspondence Source Type: research

Whether the timing of patient randomization interferes with the assessment of the efficacy of ruxolitinib for severe COVID-19
We read with great interest the article titled ‘‘Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial’’ by Cao et al.1 The study, which finally included 41 patients, evaluated the efficacy and safety of ruxolitinib for severe COVID-19 cases. They found that rux olitinib recipients had a significant chest computed tomography (CT) improvement, a faster recovery from lymphopenia, and favorable side-effect profile. However, we think it is appropriate to comment on the methods used in this study. (Source: Journal of All...
Source: Journal of Allergy and Clinical Immunology - September 17, 2020 Category: Allergy & Immunology Authors: Hailan Li, Huaping Liu Tags: Correspondence Source Type: research

Regarding “Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial”
We read with great interest the article titled ‘‘Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial’’ by Cao et al.1 The study, which finally included 41 patients, evaluated the efficacy and safety of ruxolitinib for severe COVID-19 cases. They finally found that ruxolitinib recipients had a significant chest computed tomography (CT) improvement, a faster recovery from lymphopenia, and favorable side-effect profile. However, we think it is appropriate to comment on the methods used in this study. (Source: Journal...
Source: Journal of Allergy and Clinical Immunology - September 17, 2020 Category: Allergy & Immunology Authors: Hailan Li, Huaping Liu Tags: Correspondence Source Type: research

Efficacy and safety of mepolizumab in hypereosinophilic syndrome: a Phase III, randomized, placebo-controlled trial
This is the largest interventional clinical study performed in patients with HES to date and demonstrates for the first time that mepolizumab is associated with a reduction in disease flares without significant adverse events. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 17, 2020 Category: Allergy & Immunology Authors: Florence Roufosse, Jean-Emmanuel Kahn, Marc E. Rothenberg, Andrew J. Wardlaw, Amy D. Klion, Suyong Yun Kirby, Martyn J. Gilson, Jane H. Bentley, Eric S. Bradford, Steven W. Yancey, Jonathan Steinfeld, Gerald J. Gleich Source Type: research

A substantial neutrophilic inflammation as regular part of severe type 2 chronic rhinosinusitis with nasal polyps
Capsule Summary: We show that severe type 2 CRSwNP patients display a profound neutrophilic inflammation, with increased activation status and proteolytic activity, co-existing with severe eosinophilia (EETosis and CLC-deposition), and independent of IL-17. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 16, 2020 Category: Allergy & Immunology Authors: Tim Delemarre, Gabriele Holtappels, Natalie De Ruyck, Nan Zhang, Hans Nauwynck, Claus Bachert, Elien Gevaert Source Type: research

Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development
Capsule SummaryWe identify an NLRP3 gain-of-function variant that is activated in the colon via post-translational mechanism. It will facilitate diagnosis and precision treatment for patients with NLRP3-associated VEOIBD. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 14, 2020 Category: Allergy & Immunology Authors: Lingli Zhou, Tao Liu, Bing Huang, Man Luo, Zhanghua Chen, Zhiyao Zhao, Jun Wang, Daniel Leung, Xingtian Yang, Koon Wing Chan, Yukun Liu, Liya Xiong, Peiyu Chen, Hongli Wang, Liping Ye, Hanquan Liang, Seth L. Masters, Andrew M. Lew, Sitang Gong, Fan Bai, J Source Type: research

Type 2-high asthma is associated with a specific indoor mycobiome and microbiome
This study is the first to date that investigates both the endogenous and the exogenous mycobiomes and microbiomes of asthmatic patients and reveals associations between indoor microbial communities, exacerbation, and T2 of severe asthma. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 11, 2020 Category: Allergy & Immunology Authors: V.A.N.D.E.N.B.O.R.G.H.T. Louise-Eva, Rapha ël ENAUD, Charlotte URIEN, Noémie CORON, G.I.R.O.D.E.T. Pierre-Olivier, Stéphanie FERREIRA, Patrick BERGER, Laurence DELHAES Source Type: research

ARGX-117, a therapeutic complement inhibiting antibody targeting C2
Activation of the classical and lectin pathway of complement may contribute to tissue damage and organ dysfunction of antibody-mediated diseases and ischemia-reperfusion conditions. Complement factors are being considered as targets for therapeutic intervention (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 11, 2020 Category: Allergy & Immunology Authors: Inge Van de Walle, Karen Silence, Kevin Budding, Liesbeth Van de Ven, Kim Dijkxhoorn, Elisabeth de Zeeuw, Cafer Yildiz, Sofie Gabriels, Jean-Michel Percier, Johanna Wildemann, Jan Meeldijk, Peter J. Simons, Louis Boon, Linda Cox, Rob Holgate, Rolf Urbanus Source Type: research

Air pollution and IgE sensitization in four European birth cohorts - the MeDALL project
Capsule summary: Exposure to ambient air pollution does not increase the overall risk of sensitization to inhalant and food allergens, but IgE sensitization to birch and major grass pollen allergens may be related to air pollutants. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 11, 2020 Category: Allergy & Immunology Authors: Erik Mel én, Marie Standl, Ulrike Gehring, Hicran Altug, Josep Maria Antó, Dietrich Berdel, Anna Bergström, Jean Bousquet, Joachim Heinrich, Gerard H. Koppelman, Inger Kull, Christian Lupinek, Iana Markevych, Tamara Schikowski, Elisabeth Thiering, Rudo Source Type: research

New Clinical Diagnostic Criteria for Allergic Bronchopulmonary Aspergillosis/Mycosis and its Validation
There are several clinical diagnostic criteria for allergic bronchopulmonary aspergillosis (ABPA). However, these criteria have not been validated in detail, and no criteria for allergic bronchopulmonary mycosis (ABPM) is currently available. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 10, 2020 Category: Allergy & Immunology Authors: Koichiro Asano, Akira Hebisawa, Takashi Ishiguro, Noboru Takayanagi, Yasuhiko Nakamura, Junko Suzuki, Naoki Okada, Jun Tanaka, Yuma Fukutomi, Shigeharu Ueki, Koichi Fukunaga, Satoshi Konno, Hiroto Matsuse, Katsuhiko Kamei, Masami Taniguchi, Terufumi Shimo Source Type: research

Characterization of the Cytokine Storm Reflects Hyperinflammatory Endothelial Dysfunction in COVID-19
Capsule Summary: This detailed analysis of plasma biomarkers in COVID-19 patients provides definitive understanding of the cytokine storm and changes in vascular endothelial markers that may inform us of the changes in the Ordinal scale for COVID-19. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 10, 2020 Category: Allergy & Immunology Authors: Jonathan T. Sims, Venkatesh Krishnan, Ching-Yun Chang, Sarah M. Engle, Giacomo Casalini, George H. Rodgers, Nicoletta Bivi, Brian J. Nickoloff, Robert J. Konrad, Stephanie de Bono, Richard E. Higgs, Robert J. Benschop, Silvia Ottaviani, Anabela Cardoso, A Source Type: research

CaMKII Oxidation Regulates Cockroach Allergen-Induced Mitophagy in Asthma
Capsule summaryAllergen-induced excessive activation of autophagy in airway epithelium leads to increased ROS generation and release of pathogenic cytokines through oxidized CaMKII that may contribute to the development of Th2-associated allergic airway inflammation and asthma. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 10, 2020 Category: Allergy & Immunology Authors: Yan Zhang, Danh C. Do, Xinyue Hu, Ji Wang, Yilin Zhao, Sumita Mishra, Xin Zhang, Mei Wan, Peisong Gao Source Type: research

Impact of reported NSAID “allergies” on opioid use disorder in back pain
Reported NSAID allergy represents a risk factor for OUD in patients with chronic back pain. There may be an important role for Allergy specialists in the multi-disciplinary care, evaluation, and de-labeling of patients with pain and with reported NSAID allergies. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 8, 2020 Category: Allergy & Immunology Authors: Lily Li, Yuchiao Chang, Shuang Song, Elena Losina, Karen H. Costenbader, Tanya M. Laidlaw Source Type: research

Ssu72 regulates alveolar macrophage development and allergic airway inflammation by fine tuning of GM-CSF receptor signaling
Our study demonstrates that Ssu72 phosphatase binds to GM-CSF receptor βc, regulating GM-CSF signaling strength in AMs which plays critical role in development, and functions of AMs, thereby regulating immune responses in allergic airway inflammation. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 7, 2020 Category: Allergy & Immunology Authors: Yeon Duk Woo, Jaemoon Koh, Jae Sung Ko, Sehui Kim, Kyeong Cheon Jung, Yoon Kyung Jeon, Hye Young Kim, Ho Lee, Chang Woo Lee, Doo Hyun Chung Source Type: research

IL-10 production by ILC2s requires Blimp-1 and cMaf, modulates cellular metabolism and ameliorates airway hyperreactivity
Capsule Summary: Our data illustrate a novel, immunotherapeutic potential of ILC210s that can be modulated by signaling transcription factors and cellular metabolic pathways. Therefore, our data reveal promising avenues for the treatment of ILC2-dependent airway hyperreactivity. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 6, 2020 Category: Allergy & Immunology Authors: Emily Howard, Gavin Lewis, Lauriane Galle-Treger, Benjamin P. Hurrell, Doumet Georges Helou, Pedram Shafiei-Jahani, Jacob Painter, German Aleman Muench, Pejman Soroosh, Omid Akbari Source Type: research

A 300 °IR sublingual tablet is an effective, safe treatment for house-dust-mite-induced allergic rhinitis: an international, double-blind, placebo-controlled, randomized Phase III clinical trial
Allergic rhinitis (AR) induced by house dust mites (HDMs) is a highly prevalent but often underdiagnosed and undertreated/untreated chronic disease. It often has a negative impact on sleep, work, leisure activities, and health-related quality of life. Allergen immunotherapy is a proven, safe treatment for respiratory allergies. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 2, 2020 Category: Allergy & Immunology Authors: Pascal Demoly, Jonathan Corren, Peter Creticos, Fr édéric De Blay, Philippe Gevaert, Peter Hellings, Krzysztof Kowal, Martine Le Gall, Natalia Nenasheva, Giovanni Passalacqua, Oliver Pfaar, Miguel Tortajada-Girbés, Carmen Vidal, Margitta Worm, Thomas B Source Type: research

A genome-wide association study of asthma hospitalizations in adults
Little is known about genetic determinants of severe asthma exacerbations. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 2, 2020 Category: Allergy & Immunology Authors: Qi Yan, Erick Forno, Esther Herrera-Luis, Maria Pino-Yanes, Ge Yang, Sam Oh, Edna Acosta-P érez, Donglei Hu, Celeste Eng, Scott Huntsman, José R. Rodriguez-Santana, Michelle M. Cloutier, Glorisa Canino, Esteban G. Burchard, Wei Chen, Juan C. Celedón Source Type: research

Randomized trial of early infant formula introduction to prevent cow ’s milk allergy
Previous research has produced conflicting evidence on the preventative effects of early cow ’s milk protein introduction on cow’s milk allergy (CMA). (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 2, 2020 Category: Allergy & Immunology Authors: Tetsuhiro Sakihara, Kenta Otsuji, Yohei Arakaki, Kazuya Hamada, Shiro Sugiura, Komei Ito Source Type: research

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection
The objective of this study was to provide an evidence-based review of the associated pathways and potential treatment of the hyperinflammatory state associated with severe acute respiratory syndrome coronavirus 2 infec tion. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 1, 2020 Category: Allergy & Immunology Authors: Ana Copaescu, Olivia Smibert, Andrew Gibson, Elizabeth J. Phillips, Jason A. Trubiano Tags: COVID-19 Source Type: research

News Beyond Our Pages
Detectable serum allergen-specific IgE is present without the development of allergy for unclear reasons and is responsible for up to 50% false positive rates in diagnosis of peanut allergy. Because the post-translational modification glycosylation is established to modulate the effector function of IgG, Shade et al (Nature 2020;582:265-70. https://doi.org/10.1038/s41586-020-2311-z) characterized the glycosylation patterns of serum IgE from peanut-allergic individuals and nonatopic controls. IgE from peanut-allergic individuals exhibited increased levels of sialic acid, and removal of sialic acid from IgE decreased its abi...
Source: Journal of Allergy and Clinical Immunology - September 1, 2020 Category: Allergy & Immunology Authors: Marc E. Rothenberg, Jean Bousquet Source Type: research

Neonatal Fc receptor in human immunity: Function and role in therapeutic intervention
The humoral immune response provides specific, long-lived protection against invading pathogens, via immunoglobulin production and other memory functions. IgG, the most abundant immunoglobulin isotype, has the longest half-life and protects against bacterial and viral infections. The neonatal Fc receptor (FcRn) transports IgG across barriers, for example, the placenta, enhancing fetal humoral immunity to levels similar to their mothers ’. Importantly, FcRn, by protecting IgG from intracellular degradation, results in an approximately 21-day circulating IgG half-life and high plasma levels; similarly, FcRn recycles al...
Source: Journal of Allergy and Clinical Immunology - September 1, 2020 Category: Allergy & Immunology Authors: Dhavalkumar D. Patel, James B. Bussel Tags: Reviews and feature article Source Type: research

Targeting FcRn for immunomodulation: Benefits, risks, and practical considerations
The neonatal fragment crystallizable (Fc) receptor (FcRn) functions as a recycling mechanism to prevent degradation and extend the half-life of IgG and albumin in the circulation. Several FcRn inhibitors selectively targeting IgG recycling are now moving rapidly toward clinical practice in neurology and hematology. These molecules accelerate the destruction of IgG, reducing pathogenic IgG and IgG immune complexes, with no anticipated effects on IgA, IgM, IgE, complement, plasma cells, B cells, or other cells of the innate or adaptive immune systems. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 1, 2020 Category: Allergy & Immunology Authors: Hans-Hartmut Peter, Hans D. Ochs, Charlotte Cunningham-Rundles, Donald C. Vinh, Peter Kiessling, Bernhard Greve, Stephen Jolles Tags: Reviews and feature article Source Type: research

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 1, 2020 Category: Allergy & Immunology Tags: Continuing Medical Education examination Source Type: research

The Editors ’ Choice
Although seasonal allergic rhinitis in response to pollen is  well established, the underlying immune responses, especially when it comes to identifying various cytokines, have not been scrutinized. In this issue, Gökkaya et al (p 583) set out to study the immune mediators that develop during springtime birch pollen exposure in 2 well-defined cohorts of v olunteers with and without seasonal allergic rhinitis (SAR). The subjects filled out a daily online symptom diary and underwent repeated biosampling of nasal fluid for an entire year. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 1, 2020 Category: Allergy & Immunology Authors: Zuhair K. Ballas, Associate Editors of the JACI Tags: The Editors ’ choice Source Type: research

Cover 1
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 1, 2020 Category: Allergy & Immunology Source Type: research

Brief Overview of This Month's JACI
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 1, 2020 Category: Allergy & Immunology Source Type: research

Table of Contents
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 1, 2020 Category: Allergy & Immunology Source Type: research

Editorial Board
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 1, 2020 Category: Allergy & Immunology Source Type: research

Information for Readers
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 1, 2020 Category: Allergy & Immunology Source Type: research

News & Notes
Discuss thought-provoking research, practice clinically-relevant skills and connect with colleagues at the 2021 AAAAI Virtual Annual Meeting. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 1, 2020 Category: Allergy & Immunology Source Type: research

Continuing Medical Education Calendar
The following activities offer AMA PRA Category 1 Credit ™ and meet the American Board of Allergy and Immunology (ABAI) requirements for Part II or Part IV Maintenance of Certification (MOC): (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 1, 2020 Category: Allergy & Immunology Source Type: research

Corrigendum
With regard to the Letter to the Editor in the March 2019 issue entitled ‘‘Immunologic reconstitution following hematopoietic stem cell transplantation despite lymph node paucity in NF-κB-inducing kinase deficiency’’ (J Allergy Clin Immunol 2019;143:1240-3.e4), it has been brought to the Editors’ attention that 3 authors were mistakenly omitted and should be i ncluded. The omitted authors are Nawal Al Kaabi, MD, Moza Al Hassani, MD, and Habiba Alsafar, MD. The institutional affiliation of Drs Al Kaabi and Al Hassani is the Department of Pediatrics, Sheikh Khalifa Medical City, Abu Dhabi,...
Source: Journal of Allergy and Clinical Immunology - September 1, 2020 Category: Allergy & Immunology Tags: Corrigendum Source Type: research

Coagulation factors induce human skin mast cell- and basophil-degranulation via activation of complement 5 and the C5a receptor
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 1, 2020 Category: Allergy & Immunology Authors: Yuhki Yanase, Yoshimi Matsuo, Shunsuke Takahagi, Tomoko Kawaguchi, Kazue Uchida, Kaori Ishii, Akio Tanaka, Daiki Matsubara, Koichiro Ozawa, Michihiro Hide Source Type: research

Enhancing the prediction of childhood asthma remission: integrating clinical factors with microRNAs
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 1, 2020 Category: Allergy & Immunology Authors: Alberta L. Wang, Jiang Li, Alvin T. Kho, Michael J. McGeachie, Kelan G. Tantisira Source Type: research

Efficacy and economics of targeted panel versus whole exome sequencing in 878 patients with suspected primary immunodeficiency
NGS has become a first-line tool for diagnosis of PID. However, patient access remains limited due to restricted insurance coverage and a lack of guidelines addressing use of targeted panels vs WES. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 1, 2020 Category: Allergy & Immunology Authors: Craig D. Platt, Fatima Zaman, Wayne Bainter, Kelsey Stafstrom, Abuarahman Almutairi, Margot Reigle, Sabrina Weeks, Raif S. Geha, Janet Chou, International Consortium for Immunodeficiencies Source Type: research

Dietary patterns in childhood and their effect on gut microbiota – an Asian perspective on atopy risk
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - August 26, 2020 Category: Allergy & Immunology Authors: Intan Hakimah Ismail, Christophe Lay, Noorizan HA. Majid, Way Seah Lee, Bee Wah Lee, Amir Hamzah Abdul Latiff, Hern Tze Tina Tan, Jan Knol, Yeong Yeh Lee Source Type: research

Persistent, refractory, and biphasic anaphylaxis: A  multidisciplinary Delphi study
The use of inconsistent definitions for anaphylaxis outcomes limits our understanding of the natural history and epidemiology of anaphylaxis, hindering clinical practice and research efforts. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - August 24, 2020 Category: Allergy & Immunology Authors: Timothy E. Dribin, Hugh A. Sampson, Carlos A. Camargo, David C. Brousseau, Jonathan M. Spergel, Mark I. Neuman, Marcus Shaker, Ronna L. Campbell, Kenneth A. Michelson, Susan A. Rudders, Amal H. Assa ’ad, Kimberly A. Risma, Mariana Castells, Lynda C. Sch Source Type: research

Human immune disorder associated with homozygous hypomorphic mutation affecting MALT1B splice variant
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - August 24, 2020 Category: Allergy & Immunology Authors: Necil Kutukculer, Thomas Seeholzer, Thomas J. O ’Neill, Carina Graß, Ayca Aykut, Neslihan Edeer Karaca, Asude Durmaz, Ozgur Cogulu, Guzide Aksu, Torben Gehring, Andreas Gewies, Daniel Krappmann Source Type: research

Immune dysregulation and Multisystem Inflammatory Syndrome in Children (MIS-C) in individuals with haploinsufficiency of SOCS1
To identify the mechanisms underlying the development of infection-driven autoimmune cytopenias. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - August 24, 2020 Category: Allergy & Immunology Authors: Pui Y. Lee, Craig D. Platt, Sabrina Weeks, Rachael F. Grace, George Maher, Kasey Gauthier, Sridevi Devana, Sally Vitali, Adrienne G. Randolph, Douglas R. McDonald, Raif S. Geha, Janet Chou Source Type: research

Plasma C3d levels as a diagnostic marker for complete complement factor I deficiency
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - August 24, 2020 Category: Allergy & Immunology Authors: Leslie Naesens, Julie Smet, Simon J. Tavernier, Petra Schelstraete, Levi Hoste, Stijn Lambrecht, Helene Verhelst, Jutte van der Werff Ten Bosch, Alina Ferster, Sophie Blumental, Pascale Hilbert, Tessa Kerre, Johan Van de Walle, Christoph Licht, Lubka T. R Source Type: research