A novel strategy to identify asthma-associated microbial clusters
Increasing evidence indicates that the development of asthma is associated with microbial communities in indoor environments.1,2 However, because of high temporal and spatial variations and the multidimensionality of microbiome data set, it is challenging to identify an accurate set of protective and risk microbes for asthma. The current standard is performing association analysis between asthma and microbial community composition or quantity of cellular components (eg, endotoxins or microbial volatile organic compounds). (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 18, 2020 Category: Allergy & Immunology Authors: Xi Fu, Qianqian Yuan, Yanling Li, Yu Sun Tags: Correspondence Source Type: research

Reply
In our recent report we studied associations between early-life exposure to individual bacterial genera of the indoor microbiota and the development of asthma.1 In a correspondence to this report, Fu et  al2 compliment our novel approach, but question some of the statistical choices made and ask for a new sensitivity analysis. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 18, 2020 Category: Allergy & Immunology Authors: Anne M. Karvonen, Pirkka V. Kirjavainen, Martin T äubel, Juha Pekkanen Tags: Correspondence Source Type: research

Towards personalization of asthma treatment according to trigger factors
Asthma is a severe and chronic disabling disease affecting more than 300 million people world-wide. While in the past few drugs for treatment of asthma were available, new treatment options are currently emerging which appear to be highly effective in certain subgroups of patients. Accordingly there is a need for biomarkers which allow selection of patients for refined and personalized treatment strategies. Recently, serological chip tests based on micro-arrayed allergen molecules and peptides derived from the most common rhinovirus strains have been developed which may discriminate two of the most common forms of asthma, ...
Source: Journal of Allergy and Clinical Immunology - February 18, 2020 Category: Allergy & Immunology Authors: Katarzyna Niespodziana, Kristina Borochova, Petra Pazderova, Thomas Schlederer, Natalia Astafyeva, Tatiana Baranovskaya, Mohamed-Ridha Barbouche, Evgenyi Beltiukov, Angelika Berger, Elena Borzova, Jean Bousquet, Roxana S. Bumbacea, Snezhana Bychkovskaya, Source Type: research

Toll-like receptor 2 impacts the development of oral tolerance in mouse pups via a milk-dependent mechanism
Expression of the innate immune receptor TLR2 by mothers profoundly influences oral tolerance development in mice, through a milk-dependent mechanism. Maternal innate immunity alters the impact of breast feeding on allergy development. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 14, 2020 Category: Allergy & Immunology Authors: Bassel Dawod, Ian D. Haidl, Meghan B. Azad, Jean S. Marshall Source Type: research

Anti-Saccharomyces cerevisiae Immunogloblin G and Immunoglobulin A antibodies are associated with systemic inflammation and advanced disease in hidradenitis suppurativa
This is the first prospective study showing that ASCA are biomarkers for HS, especially in severe inflammatory forms, but not in PV, supporting the contribution of a gut fungal dysbiosis to HS pathogenesis. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 13, 2020 Category: Allergy & Immunology Authors: Florence Assan, Jeremy Gottlieb, Florence Tubach, Said Lebbah, Nicolas Guigue, Geoffroy Hickman, Emeline Pape, Marine Madrange, Emmanuel Delaporte, Boualem Sendid, Fran çois Aubin, Francis Derouin, Stéphane Bretagne, Pascal Richette, Asma Smahi, Emilie Source Type: research

Primary prevention of asthma in high-risk children using HDM SLIT; assessment at age 6 years
Treatment of high-risk infants with HDM SLIT during early life resulted in a trend for reduction in asthma rates mid-childhood. This may be a viable preventative therapy for childhood asthma. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 11, 2020 Category: Allergy & Immunology Authors: Cherry Alviani, Graham Roberts, Frances Mitchell, Jane Martin, Zaraquiza Zolkipli, Louise J. Michaelis, Pandurangan Vijayanand, Ramesh Kurukulaaratchy, Hasan Arshad Source Type: research

Plasma protein profiling reflects Th1-driven immune dysregulation in common variable immunodeficiency
Pathway analysis of high-sensitivity plasma protein profiling revealed interferon- γ as an upstream regulator of immune dysregulation in CVID, which opens up for new diagnostic and treatment strategies. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 10, 2020 Category: Allergy & Immunology Authors: Jonas Hultberg, Jan Ernerudh, Marie Larsson, Åsa Nilsdotter-Augustinsson, Sofia Nyström Source Type: research

On the cause and consequences of IgE to galactose- α-1,3-galactose: A Report from the National Institute of Allergy and Infectious Disease Workshop on Understanding IgE-Mediated Mammalian Meat Allergy
The mammalian meat allergy known as the ‘α-Gal syndrome’ relates to IgE specific for galactose-α-1,3-galactose (α-Gal), an oligosaccharide which is present in cells and tissues of non-primate mammals. The recognition of delayed reactions to food derived from mammals in patients with IgE to α-Gal and also the association with tick bites has been increasing world-wide. In 2018, the National Institute of Allergy and Infectious Diseases, Division of Allergy, Immunology and Transplantation, sponsored a workshop on this emerging tick-related disease. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 10, 2020 Category: Allergy & Immunology Authors: Thomas A.E. Platts-Mills, Scott P. Commins, Tilo Biedermann, Marianne van Hage, Michael Levin, Lisa A. Beck, Maria Diuk-Wasser, Uta Jappe, Danijela Apostolovic, Michael Minnicozzi, Marshall Plaut, Jeffrey M. Wilson Source Type: research

Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis
Single-cell transcriptomic profiling of AD reveals distinct compositional and cell-specific gene expression changes, and a novel inflammatory fibroblast subpopulation that may orchestrate T-cell migration/trafficking and type 2 immune responses. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 6, 2020 Category: Allergy & Immunology Authors: Helen He, Hemant Suryawanshi, Pavel Morozov, Jes ús Gay-Mimbrera, Ester Del Duca, Hyun Je Kim, Naoya Kameyama, Yeriel Estrada, Evan Der, James G. Krueger, Juan Ruano, Thomas Tuschl, Emma Guttman-Yassky Source Type: research

Preventing Anaphylaxis Fatalities: Should We Target Bradykinin?
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 6, 2020 Category: Allergy & Immunology Authors: Allen P. Kaplan Source Type: research

Altered gut microbiota by azithromycin attenuates airway inflammation in allergic asthma
Allergic inflammation in the asthmatic airway may change gut microbiota; azithromycin treatment could alter gut microbiota (especially increased proportion of Clostridiales), reducing airway inflammation. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 6, 2020 Category: Allergy & Immunology Authors: Han-Ki Park, Youngwoo Choi, Dong-Hyun Lee, Sujeong Kim, Jong-Myung Lee, Sae Won Choi, Hee-Ra Lee, Mina Rho, Hae-Sim Park Source Type: research

Pathological and therapeutic implications of eosinophil-derived semaphorin 4D in eosinophilic chronic rhinosinusitis
Eosinophilic chronic rhinosinusitis (ECRS) is a subtype of chronic rhinosinusitis. Clinical markers for ECRS disease activity and treatment strategies have not been sufficiently established. Although semaphorins are originally identified as neuronal guidance factors, it is becoming clear that they play key roles in immune regulation and inflammatory diseases. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 5, 2020 Category: Allergy & Immunology Authors: Takeshi Tsuda, Masayuki Nishide, Yohei Maeda, Yoshitomo Hayama, Shohei Koyama, Satoshi Nojima, Hyota Takamatsu, Daisuke Okuzaki, Takayoshi Morita, Takeshi Nakatani, Yasuhiro Kato, Yoshimitsu Nakanishi, Yu Futami, Yasuhiko Suga, Yujiro Naito, Hachiro Konak Source Type: research

Baseline sputum eosinophil+neutrophil subgroups ’ clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) Cohort
Combined elevated sputum eosinophils+neutrophils in asthma associated with lowest lung function, greater healthcare utilization, and longitudinally, further spirometric loss, implicating cell-cell interactions or overlapping inflammatory pathways while increased eosinophils or neutrophils alone show less effect. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 5, 2020 Category: Allergy & Immunology Authors: A.T. Hastie, D.T. Mauger, L.C. Denlinger, A. Coverstone, M. Castro, S. Erzurum, N. Jarjour, B.D. Levy, D.A. Meyers, W.C. Moore, B. Phillips, S.E. Wenzel, J.V. Fahy, E. Israel, E.R. Bleecker, NHLBI SARP 3 Investigators Source Type: research

RIG-I and TLR4 Responses and Adverse Outcomes in Pediatric Influenza-Related Critical Illness
Suppression of both RIG-I and TLR4-mediated immune responses is common in previously immunocompetent children with critical influenza and is associated with worse clinical outcomes than suppression of either pathway alone. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 5, 2020 Category: Allergy & Immunology Authors: Tanya Novak, Mark W. Hall, Douglas R. McDonald, Margaret M. Newhams, Anushay J. Mistry, Angela Panoskaltsis-Mortari, Peter M. Mourani, Laura L. Loftis, Scott L. Weiss, Keiko M. Tarquinio, Barry Markovitz, Mary E. Hartman, Adam Schwarz, Wolfgang G. Junger, Source Type: research

Atopic Dermatitis Independently Increases Sensitization above Parental Atopy: the MPAACH Study
Early sensitization is ∼50% higher in children with atopic dermatitis compared to children from a high-risk allergy cohort with comparable rates of parental atopy. AD may increase sensitization risk over heredity alone. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 5, 2020 Category: Allergy & Immunology Authors: John W. Kroner, Asel Baatyrbek kyzy, Jeffrey W. Burkle, Lisa J. Martin, Grace K. LeMasters, David I. Bernstein, James E. Lockey, Patrick Ryan, Gurjit K. Khurana Hershey, Jocelyn M. Biagini Myers Source Type: research

Optimal Identification of Human Conventional and Non-conventional (CRTH2-IL7R α-) ILC2s Using Additional Surface Markers
We identified top GATA3-correlated cell-surface expressed genes in human ILCs by RNA-seq. The new surface markers such as CD30 and TNFR2 identified a previously unrecognized human ILC2 population, which is likely to contribute to asthma. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 4, 2020 Category: Allergy & Immunology Authors: Sucai Liu, Kapil Sirohi, Mukesh Verma, Jerome McKay, Lidia Michalec, Anand Sripada, Tomas Danhorn, Donald Rollins, James Good, Magdalena M. Gorska, Richard J. Martin, Rafeul Alam Source Type: research

An endothelial microRNA-1 –regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitis
Airway eosinophilia is a prominent feature of asthma and chronic rhinosinusitis (CRS), and the endothelium plays a key role in eosinophil trafficking. To date, microRNA-1 (miR-1) is the only microRNA known to be regulated in the lung endothelium in asthma models. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Authors: Asawari Korde, Farida Ahangari, Maria Haslip, Xuchen Zhang, Qing Liu, Lauren Cohn, Jose L. Gomez, Geoffrey Chupp, Jordan S. Pober, Anjelica Gonzalez, Shervin S. Takyar Tags: Rhinitis, sinusitis, and ocular allergy Source Type: research

Corrigendum
With regard to the Letter to the Editor in the September 2019 issue entitled ‘‘Respiratory syncytial virus nonstructural protein 1 downregulates glucocorticoid receptor expression through miR-29a’’ (J Allergy Clin Immunol 2019;144:854-857), it has been brought to the editors’ attention that an affiliation was incorrect as printed for authors Leiqiong Gao, Shi Mo, J un Xie, Sisi Chen, Xiang Wen, Xiaoru Long, and Luo Ren. Affiliation “a” for these authors should have read: The Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, Natio...
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Tags: Corrigendum Source Type: research

Corrigenda
With regard to the article in the August 2019 issue entitled “EMSY expression affects multiple components of skin barrier with relevance to atopic dermatitis” (J Allergy Clin Immunol 2019; 144:470-81), the authors report that they have identified an error in the method that was used for plotting data in Fig 5, A. The correct method is as follows: (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Tags: Corrigendum Source Type: research

The TWEAK/Fn14 axis in anaphylactic shock
Anaphylaxis, described more than 100 years ago, remains the immune response that requires the most rapid, and definitive, treatment to prevent death.1 Moreover, the sudden onset of severe anaphylaxis may be the first clue that a person is susceptible to this catastrophic and potentially life-threatening reaction.2 And, remarkably, the most effective treatment for severe anaphylaxis is intramuscular epinephrine, and this has been true for more than 40 years.1-3 (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Authors: Stephen J. Galli Tags: Editorial Source Type: research

News Beyond Our Pages
Maun et al (Cell 2019;179:417-31.e19. doi: https://doi.org/10.1016/j.cell.2019.09.009) discovered that mast cell –derived tryptase levels correlate with asthma severity independent of the degree of type 2 inflammation present. Furthermore, genetic alleles that increase the activity of tryptase decrease response to treatment with the IgE-neutralizing antibody omalizumab. In response to these findings, the aut hors generated a noncompetitive allosteric inhibitor of tryptase, which potently inhibited airway tryptase activity and reduced anaphylaxis in experimental animal models. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Authors: Marc E. Rothenberg, Jean Bousquet Tags: News beyond our pages Source Type: research

Telemedicine and emerging technologies for health care in allergy/immunology
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Tags: Continuing Medical Education examination Source Type: research

The Editors ’ Choice
Children with asthma are at risk for lower lung function in adulthood. Current asthma medications do little to mitigate this risk. In this issue, Grant et  al (p 646) examined whether reduction of mouse allergen exposure in mouse-allergic asthmatic children affected lung function growth over 1 year. They report that: (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Authors: Zuhair K. Ballas, Associate Editors of the JACI Tags: The Editors ’ choice Source Type: research

Telemedicine and emerging technologies for health care in allergy/immunology
Telemedicine (TM) has become a popular method of accessing medical services between providers and patients and is viewed as a cost-effective alternative to more traditional episodic face-to-face encounters. TM overcomes 2 barriers that patients face when seeking health care: distance and time. It is as effective as in-person visits for outpatient treatment of asthma, and it is a convenient way to provide inpatient consultations for patients when the allergist practices outside of the hospital. TM also has been used to manage patients with asthma in schools. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Authors: Jay M. Portnoy, Aarti Pandya, Morgan Waller, Tania Elliott Tags: Reviews and feature article Source Type: research

Cover 1
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Source Type: research

Brief Overview of This Month's JACI
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Source Type: research

Table of Contents
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Source Type: research

Editorial Board
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Source Type: research

Information for Readers
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Source Type: research

News & Notes
Join thousands of allergist/immunologists, allied health professionals and other industry experts at the premier event in A/I. With hundreds of sessions ranging from the latest in basic science to practical information for clinical applications, there ’s something for everyone at the AAAAI Annual Meeting. This year’s clinical theme will focus on biologics. The theme makes up about 20% of the sessions at the Annual Meeting and is chosen based on the needs of the AAAAI membership. Registration onsite will be available, so it’s not too late to plan your trip to “The City of Brotherly Love.” (Sour...
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Tags: Reader service Source Type: research

Continuing Medical Education Calendar
The following activities offer AMA PRA Category 1 Credit ™ and meet the ABAI requirements for Part II or Part IV MOC: (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Source Type: research

Current perspective of the etiopathogenesis of delayed-type, and T cell-mediated drug related skin diseases
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Authors: Marc Vocanson, Dean J. Naisbitt, Jean-Fran çois Nicolas Source Type: research

Treatment of severe lichen planus with the JAK inhibitor tofacitinib
Lichen planus (LP) is frequently difficult to treat. Here we show that JAK-STAT signaling is activated in LP and that treatment with a JAK inhibitor, tofacitinib, was effective in 3 patients with recalcitrant erosive LP. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Authors: William Damsky, Alice Wang, Brianna Olamiju, Danielle Peterson, Anjela Galan, Brett King Source Type: research

The Potential of microRNAs as Non-invasive Biomarkers in Acute Pediatric Asthma
Our study demonstrated that it ’s feasible to obtain quality microRNAs from nasal epithelium in ED setting. We found that miR-582-5p is overexpressed in severe asthmatics suggesting future potential of this microRNA as a clinical biomarker. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Authors: Aleksandra Trifunovic, Alan Dombkowski, Daniela Cukovic, Prashant Mahajan Source Type: research

Improving the diagnostic yield for filaggrin; concealed mutations in the Dutch population
This study emphasizes screening of the entire FLG gene beyond population-specific mutations. Screening was simplified by implementing single-molecule molecular-inversion-probes and NextGeneration Sequencing. The diagnostic yield of FLG mutations increased identifying novel mutations and enhancing further research opportunities. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Authors: Frank S. van Leersum, Ivo F. Nagtzaam, Carolien N. van Oosterhoud, Stijn A.I. Ghesquiere, Roel R.H.F.J. Brandts, Antoni Gosty ński, Peter M. Steijlen, Michel van Geel Source Type: research

Serum folate metabolites, asthma, and lung function in a nationwide U.S. study
In a U.S. nationwide study, a high serum 5-MTHF to UMFA ratio is associated with decreased odds of asthma, increased FEV1 in children and adults, and increased FVC in adults. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Authors: Yueh-Ying Han, Erick Forno, Franziska Rosser, Juan C. Celed ón Source Type: research

Understanding the Asthmatic Response to an Experimental Rhinovirus Infection: Exploring the Effects of Blocking IgE
Allergic asthmatics experienced an augmented response to an experimental rhinovirus infection very early in the infection and during symptom resolution. The beneficial effect of blocking IgE with omalizumab was most prominent early in the infection. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Authors: Peter W. Heymann, Thomas AE. Platts-Mills, Judith A. Woodfolk, Larry Borish, Deborah D. Murphy, Holliday T. Carper, Mark R. Conaway, John W. Steinke, Lyndsey Muehling, Teague W. Gerald, Joshua L. Kennedy, Anne-Marie Irani, Matthew D. McGraw, Stephen V. Ea Source Type: research

Mast cells initiate the vascular response to contact allergens by sensing cell stress
Mast cells (MCs) contact hypersensitivity responses, but the mode of MC activation is not yet understood. Hoppe et al. show, that MCs trigger an immediate edema formation and neutrophil infiltration by sensing cell stress concomitantly via the ATP/P2X7 and IL-33/ST2 pathway. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2020 Category: Allergy & Immunology Authors: Anja Hoppe, Konstantinos Katsoulis-Dimitriou, Hanna Edler, Jan Dudeck, Sebastian Drube, Anne Dudeck Source Type: research

Genetics of chronic rhinosinusitis
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - January 30, 2020 Category: Allergy & Immunology Authors: Kyle B. Mitts, Eugene H. Chang Source Type: research

TEMPORARY REMOVAL: Update on the NAEPP asthma guidelines: The wait is over, or is it?
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated.The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - January 28, 2020 Category: Allergy & Immunology Authors: Stanley J. Szefler Source Type: research

Serum IL-6: A Biomarker in Childhood Asthma?
Serum IL-6 was associated with asthma exacerbation risk but not with symptoms or lung function in urban children; further studies to evaluate the role of IL-6 in the life course of asthma are needed. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - January 28, 2020 Category: Allergy & Immunology Authors: Daniel J. Jackson, Leonard B. Bacharier, Agustin Calatroni, Michelle A. Gill, Jack Hu, Andrew H. Liu, Lisa M. Wheatley, James E. Gern, Rebecca S. Gruchalla, Gurjit K. Khurana Hershey, Meyer Kattan, Carolyn M. Kercsmar, Haejin Kim, George T. O ’Connor, S Source Type: research

αIIb-integrin (CD41) associated with blood eosinophils is a potential biomarker for disease activity in eosinophilic esophagitis
Capsule summary: After EoE treatment, association of platelets with blood eosinophils, as reported by CD41, predicted esophageal eosinophil count. Percentage CD41+ circulating eosinophils is a potential non-invasive biomarker for EoE disease activity. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - January 28, 2020 Category: Allergy & Immunology Authors: Mats W. Johansson, Elizabeth M. McKernan, Paul S. Fichtinger, Evelyn L. Angulo, Jennifer L. Bagley, Kristine E. Lee, Michael D. Evans, Luis D. Lomeli, Deane F. Mosher, Shelly M. Cook, Eric A. Gaumnitz, Sameer K. Mathur Source Type: research

Clinical Factors Associated with Acute Exacerbations of Chronic Rhinosinusitis
This study identifies associations between high-risk patients with CRS experiencing frequent exacerbations requiring antibiotics, and allergic and immunologic diseases. Improved understanding of this patient population can lead to targeted interventions to reduce exacerbation frequency. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - January 28, 2020 Category: Allergy & Immunology Authors: Jason H. Kwah, Shaan N. Somani, Whitney W. Stevens, Robert C. Kern, Stephanie S. Smith, Kevin C. Welch, David B. Conley, Bruce K. Tan, Leslie C. Grammer, Amy Yang, Robert P. Schleimer, Anju T. Peters Source Type: research

Update on the NAEPP asthma guidelines: The wait is over, or is it?
As an asthma specialist, one is often asked to discuss the asthma guidelines. The challenge that one faces is what guidelines do you use as a resource for discussion or presentation? It often comes down to: What is the question? What message does one want to deliver? And where is the most current information? Who is the target audience? This commentary will help answer those questions as it guides the reader through the new draft update of the NHLBI/NAEPP guidelines and then outlines differences between two widely used strategies for the management of asthma: the Global Initiative for Asthma (GINA) and the National Heart, ...
Source: Journal of Allergy and Clinical Immunology - January 28, 2020 Category: Allergy & Immunology Authors: Stanley J. Szefler Source Type: research

Anaphylaxis – a 2020 Practice Parameter Update, Systematic Review and GRADE Analysis
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - January 27, 2020 Category: Allergy & Immunology Authors: Marcus S. Shaker, Dana V. Wallace, David BK. Golden, John Oppenheimer, Jonathan A. Bernstein, Ronna CL. Campbell, Chitra Dinakar, Anne Ellis, Matthew Greenhawt, David A. Khan, David M. Lang, Eddy S. Lang, Jay A. Lieberman, Jay Portnoy, Matthew A. Rank, Da Source Type: research

2019: The Year in Review
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - January 27, 2020 Category: Allergy & Immunology Authors: Zuhair K. Ballas Source Type: research

Endotypes of chronic rhinosinusitis: impact on management
Following the trend in asthma, endotypes for chronic rhinosinusitis with nasal polyps (CRSwNP) have been established, with Type 2 immune reactions representing 80-100% of nasal polyp cases in Europe and the US. Endotyping is without doubt useful to predict the natural course of disease, to determine pharmacotherapy and the extent of surgery, and lately also to select patients for Type 2 biologics. However, with the opening of this new era of treatment, also limitations of the current possibilities in subgrouping patients became apparent, as 1) mixed endotypes often can be found and 2) predictions on the best biologic to be...
Source: Journal of Allergy and Clinical Immunology - January 27, 2020 Category: Allergy & Immunology Authors: Lars-Olaf Cardell, P är Stjärne, Karin Jonstam, Claus Bachert Source Type: research

Superantigen-related Th2 CD4+ T Cells in Non-asthmatic Chronic Rhinosinusitis with Nasal Polyps
Superantigen-related CD4+ T cells were expanded in NPs and ethmoidal mucosal tissues from non-asthmatic CRSwNP patients and exhibited a potent Th2 cytokine-producing ability. In addition, their expansion was associated with disease extent in CRSwNP. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - January 24, 2020 Category: Allergy & Immunology Authors: Min-Seok Rha, Sang-Wook Kim, Dong-Yeop Chang, Jin-Ku Lee, Jihye Kim, Su-Hyung Park, Roza Khamulratova, Hee-Suk Lim, Kyoung Mi Eun, Seung-No Hong, Dae Woo Kim, Eui-Cheol Shin Source Type: research

Severe combined immunodeficiency caused by Inositol-trisphosphate 3-Kinase B (ITPKB) deficiency
We identified a novel cause of T-B+NK+ severe combined immunodeficiency due to homozygous frameshift mutation in ITPKB, demonstrating the critical role of ITPKB in human T cell development. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - January 24, 2020 Category: Allergy & Immunology Authors: Abduarahman Almutairi, Jacqueline G. Wallace, Faris Jaber, Mohammed F. Alosaimi, Jennifer Jones, Mohamed T.H. Sallam, Marwa H. Elnagdy, Janet Chou, Ali Sobh, Raif S. Geha Source Type: research

Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts
Very few studies have examined the association between long-term outdoor air pollution and rhinitis severity in adults. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - January 23, 2020 Category: Allergy & Immunology Authors: Emilie Burte, B énédicte Leynaert, Alessandro Marcon, Jean Bousquet, Meriem Benmerad, Roberto Bono, Anne-Elie Carsin, Kees de Hoogh, Bertil Forsberg, Frederic Gormand, Joachim Heinrich, Jocelyne Just, Mark Nieuwenhuijsen, Isabelle Pin, Morgane Stempfele Source Type: research