Metabolomic profiling revealed altered lipid metabolite levels in childhood food allergy
The pathophysiology of childhood food allergy (FA) and its natural history are poorly understood. Clarification of the underlying mechanism may aid in identifying novel biomarkers and strategies for clinical intervention in children with FA. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 26, 2021 Category: Allergy & Immunology Authors: Haerin Jang, Eun Gyul Kim, Mina Kim, Soo Yeon Kim, Yoon Hee Kim, Myung Hyun Sohn, Kyung Won Kim Source Type: research

2021 Year in Review: Spotlight on Eosinophils
This review highlights recent advances in the understanding of eosinophils and eosinophilic diseases, particularly eosinophilic gastrointestinal diseases during the last year. The increasing incidence of diseases marked by eosinophilia has been documented and highlighted the need to understand eosinophil biology and eosinophilic contributions to disease. Significant insight into the nature of eosinophilic diseases has been achieved using next-generation sequencing technologies, proteomic analysis, and machine learning to analyze tissue biopsies. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 25, 2021 Category: Allergy & Immunology Authors: Julia L.M. Dunn, Marc E. Rothenberg Source Type: research

Autoimmune Consequences of Biologics
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 24, 2021 Category: Allergy & Immunology Authors: Rashmi Dhital, Arthur Kavanaugh Source Type: research

Dynamic Manifestation of Autoimmune Diseases in Skin – Cytokine Hubs and Paradoxical Reactions
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 24, 2021 Category: Allergy & Immunology Authors: Shuai Shao, Allison C. Billi, Johann E. Gudjonsson Source Type: research

The COVID-19 as an infectome paradigm of autoimmunity
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 23, 2021 Category: Allergy & Immunology Authors: Arad Dotan, Naim Mahroum, Dimitrios P. Bogdanos, Yehuda Shoenfeld Source Type: research

The epithelial barrier hypothesis proposes a comprehensive understanding of the origins of allergic and other chronic non-communicable diseases
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 22, 2021 Category: Allergy & Immunology Authors: Cezmi A. Akdis Source Type: research

CD38 plays an age-related role in cholinergic deregulation of airway smooth muscle contractility
The acetylcholine-PI3K/Akt-CD38 pathway is a potential anti-AHR target in asthmatic children. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 17, 2021 Category: Allergy & Immunology Authors: Yan Bai, Alonso G.P. Guedes, Ramaswamy Krishnan, Xingbin Ai Source Type: research

Antibody-mediated Neuropsychiatric Disorders
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 17, 2021 Category: Allergy & Immunology Authors: Josep Dalmau, Francesc Graus Source Type: research

Severe COVID-19 is associated with hyperactivation of the alternative complement pathway
We show that activation of the alternative complement pathway characterizes COVID-19 severity. Specifically, low properdin levels were associated with use of mechanical ventilation. This work provides a rationale for the specific inhibition of the alternative complement pathway. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 16, 2021 Category: Allergy & Immunology Authors: Jeremy Boussier, Nader Yatim, Armance Marchal, J érôme Hadjadj, Bruno Charbit, Carine El Sissy, Nicolas Carlier, Frédéric Pène, Luc Mouthon, Pierre-Louis Tharaux, Anne Bergeron, David M. Smadja, Frédéric Rieux-Laucat, Darragh Duffy, Solen Kernéis, Source Type: research

Immune checkpoints skewing might be the cause of continuous immune activation in nasal polyps; new opportunities for therapies.
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 16, 2021 Category: Allergy & Immunology Authors: Alex KleinJan Source Type: research

Discovering metabolite quantitative trait loci in asthma using an isolated population
Integration of metabolomics with genetics may advance understanding of disease pathogenesis but has been underutilized in asthma genetic studies. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 12, 2021 Category: Allergy & Immunology Authors: Randi K. Johnson, Tonya Brunetti, Kevin Quinn, Katrina Doenges, Monica Campbell, Christopher Arehart, Margaret A. Taub, Rasika A. Mathias, Nichole Reisdorph, Kathleen C. Barnes, Michelle Daya Source Type: research

Μένος: power, life force, and purpose in mentoring
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 12, 2021 Category: Allergy & Immunology Authors: Kathleen E. Sullivan Source Type: research

TNF-inhibition in vasculitis management in adenosine deaminase 2 deficiency (DADA2)
Deficiency of adenosine deaminase 2 (DADA2) is a recessively inherited autoinflammatory disorder caused by a loss of functional ADA2 protein. TNF inhibition (TNFi) has proven to be highly effective in treating inflammatory manifestations. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 11, 2021 Category: Allergy & Immunology Authors: Natalie T. Deuitch, Dan Yang, Pui Y. Lee, Xiaomin Yu, Natalia Sampaio Moura, Oskar Schnappauf, Amanda K. Ombrello, Deborah Stone, Hye Sun Kuehn, Sergio D. Rosenzweig, Patrycja Hoffmann, Cornelia Cudrici, Deborah M. Levy, Elizabeth Kessler, Jennifer B. Soe Source Type: research

Treatment of chronic or relapsing COVID-19 in immunodeficiency
Patients with some types of immunodeficiency can suffer chronic or relapsing infection with SARS-CoV-2. This leads to morbidity and mortality, infection control challenges and the risk of evolution of novel viral variants. Optimal treatment for chronic COVID-19 is unknown. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 11, 2021 Category: Allergy & Immunology Authors: Li-An K. Brown, Ed Moran, Anna Goodman, Helen Baxendale, William Bermingham, Matthew Buckland, Iman AbdulKhaliq, Hannah Jarvis, Michael Hunter, Surendra Karanam, Aisha Patel, Megan Jenkins, Alexander Robbins, Sujoy Khan, Thomas Simpson, Stephen Jolles, Jo Source Type: research

Thunderstorm Asthma in Seasonal Allergic Rhinitis: The TAISAR study
Thunderstorm asthma (TA) epidemics are events with a potentially catastrophic impact and this study is the first to define thresholds in accessible clinical tests that indicate increased TA risk in those with seasonal allergic rhinitis. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 10, 2021 Category: Allergy & Immunology Authors: Jo A. Douglass, Caroline Lodge, Samantha Chan, Alice Doherty, Ju Ann Tan, Celina Jin, Alastair Stewart, Anne M. Southcott, Andrew Gillman, Joy Lee, Danny Csutoros, Liam Hannan, Laurence Ruane, Sara Barnes, Lou Irving, Nur-Shirin Harun, Phillipe Lachapelle Source Type: research

Molecular and clinical effects of selective TYK2 inhibition with deucravacitinib in psoriasis
This manuscript describes the molecular and clinical responses of patients with psoriasis treated with deucravacitinib, a selective tyrosine kinase 2 (TYK2) inhibitor. Findings support selectivity of deucravacitinib for TYK2 over Janus kinases 1 –3. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 9, 2021 Category: Allergy & Immunology Authors: Ian M. Catlett, Yanhua Hu, Lu Gao, Subhashis Banerjee, Kenneth Gordon, James G. Krueger Source Type: research

Biologics for chronic rhinosinusitis with nasal polyps (CRSwNP)
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 6, 2021 Category: Allergy & Immunology Authors: Glenis K. Scadding, Guy W. Scadding Source Type: research

Cellular and systemic energy metabolic dysregulation in asthma development —a hypothesis-generating approach
The roles of systemic and airway-specific epithelial energy metabolism in altering the developmental programming of airway epithelial cells (AECs) in early life are poorly understood. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 2, 2021 Category: Allergy & Immunology Authors: Sergejs Berdnikovs, Dawn C. Newcomb, Tebeb Gebretsadik, Brittney M. Snyder, Derek A. Wiggins, Kadijah S. Poleon, Tina V. Hartert Tags: Brief report Source Type: research

Targeting IgE polyadenylation signal with antisense oligonucleotides decreases IgE secretion and plasma cell viability
This study demonstrates that targeting the secreted IgE polyadenylation signal using antisense oligonucleotides strongly reduces IgE secretion and provokes apoptosis of IgE-expressing plasma cells, opening new therapeutic perspectives in patients suffering from IgE-dependent allergic diseases. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 2, 2021 Category: Allergy & Immunology Authors: Anne Marchalot, Catherine Horiot, Jean-Marie Lambert, Claire Carrion, Christelle Oblet, Justine Pollet, Michel Cogn é, Jeanne Moreau, Brice Laffleur, Laurent Delpy Source Type: research

Efficacy and Safety of Baked Milk Oral Immunotherapy in Children with Severe Milk Allergy: A Randomized, Double-blind, Placebo-controlled Phase 2 Trial
Cow ’s milk allergy is the most common food allergy in young children and has no current treatment. Oral immunotherapy studies to date have shown efficacy but high rates of adverse reactions. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 2, 2021 Category: Allergy & Immunology Authors: Jennifer Dantzer, Joan Dunlop, Kevin J. Psoter, Corinne Keet, Robert Wood Source Type: research

Cellular and systemic energy metabolic dysregulation in asthma development- a hypothesis-generating approach
The roles of systemic and airway-specific epithelial energy metabolism in altering the developmental programming of airway epithelial cells (AECs) in early life are poorly understood. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 2, 2021 Category: Allergy & Immunology Authors: Sergejs Berdnikovs, Dawn C. Newcomb, Tebeb Gebretsadik, Brittney M. Snyder, Derek A. Wiggins, Kadijah S. Poleon, Tina V. Hartert Source Type: research

Corrigendum
With regard to the article in the October 2020 issue entitled “Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations” (J Allergy Clin Immunol 2020;146:901-11), the authors report the following errors regarding the nomenclature of several variants/mutations in NFKB1, to be amended as follows: (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2021 Category: Allergy & Immunology Tags: Corrigendum Source Type: research

News Beyond Our Pages
Izadi et al (Am J Respir Crit Care Med 2021 May 24; https://doi.org/10.1164/rccm.202010-3763OC) utilized data from the Childhood Asthma Management Program longitudinal cohort, which consists of pediatric subjects with mild-to-moderate asthma, in order to identify the childhood factors that predict the development of severe persistent asthma later in life. Low post-bronchodilator FEV1/FVC ratio and maternal smoking during pregnancy significantly increased the risk of developing persistent severe asthma from late adolescence into early adulthood. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2021 Category: Allergy & Immunology Authors: Marc E. Rothenberg, Jean Bousquet Tags: News beyond our pages Source Type: research

The impact of environmental injustice and social determinants of health on the role of air pollution in asthma and allergic disease in the United States
There is clear evidence that exposure to environmental air pollution is associated with immune dysregulation, asthma, and other allergic diseases. However, the burden of air pollution exposure is not equally distributed across the United States. Many social and environmental factors place communities of color and people who are in poverty at increased risk of exposure to pollution and morbidity from asthma and allergies. Here, we review the evidence that supports the relationship between air pollution and asthma, while considering the social determinants of health that contribute to disparities in exposures and outcomes. (...
Source: Journal of Allergy and Clinical Immunology - November 1, 2021 Category: Allergy & Immunology Authors: Quindelyn Cook, Kira Argenio, Stephanie Lovinsky-Desir Tags: Reviews and feature article Source Type: research

The impact of environmental injustice and social determinants of health on the role of air pollution in asthma and allergic disease in the United States
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2021 Category: Allergy & Immunology Tags: Reviews and feature articles Source Type: research

Structural racism and its pathways to asthma and atopic dermatitis
Black, Latinx, and Indigenous people in the United States experience a disproportionate burden of asthma and atopic dermatitis. The study of these disease disparities has focused on proximal socioenvironmental exposures and on the biomechanistic (including genetic) differences between racial and ethnic groups. Although biomedical research in allergy and immunology stands to benefit from the inclusion of diverse study populations, the narrow focus on biologic mechanisms disregards the complexity of interactions across biologic and structural factors, including the effects of structural racism. (Source: Journal of Allergy an...
Source: Journal of Allergy and Clinical Immunology - November 1, 2021 Category: Allergy & Immunology Authors: Adali Martinez, Rosemarie de la Rosa, Mahasin Mujahid, Neeta Thakur Tags: Reviews and feature article Source Type: research

The Editors ’ Choice
Both asthma and obesity disproportionately affect minority children and those in low-income families. While several studies have demonstrated associations between childhood obesity and asthma, few have investigated patterns of weight gain in early childhood and the development of asthma, particularly in high-risk populations. In this issue, Lovinsky-Desir et  al (p 1219) examined trajectories of several different indicators of adiposity in a longitudinal birth cohort of 609 predominately Black and Latinx children living in 4 US cities. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2021 Category: Allergy & Immunology Tags: The Editors ’ choice Source Type: research

Cover 1
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2021 Category: Allergy & Immunology Source Type: research

Brief Overview of This Month's JACI
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2021 Category: Allergy & Immunology Source Type: research

Table of Contents
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2021 Category: Allergy & Immunology Source Type: research

Editorial Board
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2021 Category: Allergy & Immunology Source Type: research

Information for Readers
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2021 Category: Allergy & Immunology Source Type: research

News & Notes
Simulated patient encounters that provide you with real-life situations in an interactive learning environment are the focus of two new modules launched as part of a new “Providing Enhanced Medical Support for Patients with Primary Immunodeficiency Disorders (PIDD)” program offered by the AAAAI to address skill gaps in the diagnosis and care of patients with PIDD. The two new modules are: (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2021 Category: Allergy & Immunology Tags: Reader service Source Type: research

CME Calendar-AAAAI
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2021 Category: Allergy & Immunology Source Type: research

Immune Health Grades: Finding Resilience in the COVID-19 Pandemic and Beyond
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2021 Category: Allergy & Immunology Authors: Vincent C. Marconi, Venkatesh Krishnan, E. Wesley Ely, Monty Montano Source Type: research

Isotype-specific binding patterns of serum antibodies to multiple conformational epitopes of Bet v 1
Capsule summary: Mapping of conformational epitopes of the major birch pollen allergen, Bet v 1, using chimeric proteins showed that epitope recognition profiles were specific to each patient and differed between IgE, IgG1 and IgG4. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 1, 2021 Category: Allergy & Immunology Authors: Stefanie Schmalz, Vanessa Mayr, Alexandra Shosherova, Barbara Gepp, Daniela Ackerbauer, Gunter Sturm, Barbara Bohle, Heimo Breiteneder, Christian Radauer Source Type: research

Allergists are critical in actively guiding  schools in the development of food allergy policies
We read with interest the guidelines set forth by Waserman et  al1 for preventing and managing food-induced allergic reactions in child care centers and schools. Evidence dating back decades highlights the fact that schools are unprepared for medical emergencies, specifically anaphylaxis.2 Various groups have set forth recommendations encompassing food polici es and education for school staff in an attempt to address this need3; however, as detailed in the article by Waserman et al,1 there is no evidence that schools are any better prepared than they were 20 years ago. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 29, 2021 Category: Allergy & Immunology Authors: Alice E.W. Hoyt, Jennifer E. Goertz Tags: Correspondence Source Type: research

Reply
I would like to thank Hoyt and Goertze1 for their thoughtful comments on our recent article “Prevention and management of allergic reactions to food in child care centers and schools: Practice guidelines,” which appeared in the Journal of Allergy and Clinical Immunology earlier this year.2 We wholeheartedly agree that allergists have important roles to play in supporting the management of food allergy in child care centers and schools. Allergists and other health care professionals who support community members affected by allergy are among the intended audience of these guidelines, and it was an oversight on o...
Source: Journal of Allergy and Clinical Immunology - October 29, 2021 Category: Allergy & Immunology Authors: Susan Waserman Tags: Correspondence Source Type: research

Advances in Atopic Dermatitis in 2019-2020: Endotypes from skin barrier, ethnicity, properties of antigen, cytokine profiles, microbiome, and engagement of immune cells
Key research advances in atopic dermatitis (AD) suggest the complexity of its endotypes. A comprehensive serum biomarker panel revealed at least four types of AD. Some represent classic TH2-dominant AD with filaggrin mutations commonly reported in Europeans, a simultaneously activated multipolar axes of cytokines often reported in Asians, and an intrinsic type characterized by TH2-inferiority. Innate lymphoid cells, including NK cells, NKT cells, and fibroblasts, play a role in AD development and heterogeneity. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 28, 2021 Category: Allergy & Immunology Authors: Takashi Nomura, Kenji Kabashima Source Type: research

Hematopoietic cell transplantation in severe combined immunodeficiency: the SCETIDE 2006-2014 European cohort
This SCETIDE study on SCID transplants is the first to report similar 2-year event free survival for genetic subgroups. Absolute na ïve CD4 T-lymphocytes numbers at 1-year post-transplant strongly predict an uncomplicated clinical and immunological outcome (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 27, 2021 Category: Allergy & Immunology Authors: Arjan C. Lankester, Benedicte Neven, Nizar Mahlaoui, Erik GJ. von Asmuth, Virginie Courteille, Mikael Alligon, Michael H. Albert, Isabelle Badell Serra, Peter Bader, Dmitry Balashov, Rita Beier, Yves Bertrand, Stephane Blanche, Victoria Bordon, Robbert G. Source Type: research

Immune checkpoint molecules on ILC2s as potential therapeutic targets for allergic diseases
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 26, 2021 Category: Allergy & Immunology Authors: Hideaki Morita, Hirohisa Saito, Kenji Matsumoto Source Type: research

Epidemiology and management of asthma and atopic dermatitis in sub-Saharan Africa
This article provides an update on epidemiology, availability, and access of management strategies to patients suffering from bronchial asthma or atopic dermatitis in SSA. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 26, 2021 Category: Allergy & Immunology Authors: Chrysanthi Skevaki, James S. Ngocho, Caroline Amour, Peter Schmid-Grendelmeier, Blandina T. Mmbaga, Harald Renz Source Type: research

Caspase 8 Sounds the Alarm for Allergic Inflammation
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 23, 2021 Category: Allergy & Immunology Authors: Xueping Zhu, Caroline L. Sokol Source Type: research

SARS-CoV-2 –specific B- and T-cell immunity in a population-based study of young Swedish adults
Young adults are now considered major spreaders of coronavirus disease 2019 (COVID-19) disease. Although most young individuals experience mild to moderate disease, there are concerns of long-term adverse health effects. The impact of COVID-19 disease and to which extent population-level immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exists in young adults remain unclear. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 22, 2021 Category: Allergy & Immunology Authors: Sophia Bj örkander, Likun Du, Fanglei Zuo, Sandra Ekström, Yating Wang, Hui Wan, Natalia Sherina, Lisanne Schoutens, Juni Andréll, Niklas Andersson, Antonios Georgelis, Anna Bergström, Harold Marcotte, Inger Kull, Lennart Hammarström, Erik Melén, Qi Source Type: research

SARS-CoV-2 specific B- and T-cell immunity in a population-based study of young Swedish adults
Young adults are now considered major spreaders of COVID-19 disease. Although most young individuals suffer from mild to moderate disease, there are concerns of long-term adverse health effects. The impact of COVID-19 disease and to which extent population-level immunity against SARS-CoV-2 exist in young adults remain unclear. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 22, 2021 Category: Allergy & Immunology Authors: Sophia Bj örkander, Likun Du, Fanglei Zuo, Sandra Ekström, Yating Wang, Hui Wan, Natalia Sherina, Lisanne Schoutens, Juni Andréll, Niklas Andersson, Antonios Georgelis, Anna Bergström, Harold Marcotte, Inger Kull, Lennart Hammarström, Erik Melén, Qi Source Type: research

Human stem cell-derived thymic epithelial cells enhance human T-cell development in a xenogeneic thymus
Generation of thymic tissue from pluripotent stem cells would provide therapies for acquired and congenital thymic insufficiency states. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 21, 2021 Category: Allergy & Immunology Authors: Rafael Gras-Pe ña, Nichole M. Danzl, Mohsen Khosravi-Maharlooei, Sean R. Campbell, Amanda E. Ruiz, Christopher A. Parks, William Meng Suen Savage, Markus A. Holzl, Debanjana Chatterjee, Megan Sykes Source Type: research

Upregulation of type 1 conventional dendritic cells implicates antigen cross-presentation in multisystem inflammatory syndrome
Multisystem inflammatory syndrome in children (MIS-C) is an acute, febrile, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated syndrome, often with cardiohemodynamic dysfunction. Insight into mechanism of disease is still incomplete. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 21, 2021 Category: Allergy & Immunology Authors: Janice J. Huang, Samantha B. Gaines, Mateo L. Amezcua, Tamar R. Lubell, Peter S. Dayan, Marissa Dale, Alexis D. Boneparth, Mark D. Hicar, Robert Winchester, Mark Gorelik Source Type: research

Human Stem Cell-Derived Thymic Epithelial Cells Enhance Human T Cell Development in a Xenogeneic Thymus.
Capsule SummaryHuman thymic epithelial cell progenitors generated from human pluripotent stem cells with a new protocol can support human thymopoiesis both in reaggregate grafts and in porcine thymic grafts, advancing potential treatment of human thymic insufficiencies. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 21, 2021 Category: Allergy & Immunology Authors: Rafael Gras-Pena, Nichole M. Danzl, Mohsen Khosravi-Maharlooei, Sean R. Campbell, Amanda E. Ruiz, Christopher A. Parks, William Meng Suen Savage, Markus A. Holzl, Debanjana Chatterjee, Megan Sykes Source Type: research

Climate Change and Global Issues in Allergy and Immunology
The steady increase in global temperatures, resulting from the combustion of fossil fuels and the accumulation of greenhouse gases (GHG), continues to destabilize all ecosystems worldwide. Although annual emissions must halve by 2030 and reach net-zero by 2050 to limit some of the most catastrophic impacts associated with a warming planet, the world ’s efforts to curb GHG emissions fall short of the commitments made in the 2015 Paris Agreement (1). To this effect, July 2021 was recently declared the hottest month ever recorded in 142 years (2). (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 21, 2021 Category: Allergy & Immunology Authors: Susan E. Pacheco, Guillermo Guidos, Isabella Annesi-Maesano, Ruby Pawankar, Gennaro D' Amato, Patricia Latour-Staffeld, Marylin Urrutia-Pereira, Matthew J. Kesic, Michelle L. Hernandez, AAAAI Environmental Exposures and Respiratory Health Committee Source Type: research

Glucocorticoids inhibit human hematopoietic stem cell differentiation toward a common ILC precursor
Capsule summary: GC treatment in patients receiving HSCT acts on HSC and induces a defect in hILCs development, which may affect innate defense against pathogens and the homeostasis of mucosal tissues. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 21, 2021 Category: Allergy & Immunology Authors: Linda Quatrini, Nicola Tumino, Francesca Besi, Cecilia Ciancaglini, Federica Galaverna, Antonio Giacomo Grasso, Pietro Merli, Franco Locatelli, Paola Vacca, Lorenzo Moretta Source Type: research