Population descriptors in asthma and allergy research: Time to re-group
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 18, 2024 Category: Allergy & Immunology Authors: Carole Ober, Christine L.M. Joseph, John Novembre Source Type: research

β1 integrin-mediated mast cell immune-surveillance of blood vessel content
Immunoglobulin E, IgE)-mediated degranulation of mast cells, MCs) provides rapid protection against environmental hazards, including animal venoms. A fraction of tissue-resident MCs intimately associates with blood vessels. These perivascular MCs were reported to extend projections into the vessel lumen and to be the first MCs to acquire intravenously injected IgE, suggesting that IgE loading of MCs depends on their vascular association. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 15, 2024 Category: Allergy & Immunology Authors: Kristina Link, Lina Muhandes, Anastasia Polikarpova, Tim L ämmermann, Michael Sixt, Reinhard Fässler, Axel Roers Source Type: research

A Practical Guide for Implementing Omalizumab Therapy for Food Allergy
The recent approval of omalizumab for the treatment of IgE-mediated food allergy is an important step forward for the millions of food allergy patients in the US. Through the depletion of circulating IgE and the subsequent reduction of FC εR1 on key effector cells, patients increase their tolerance to food allergens. However, omalizumab does not permit patients to eat foods that they are allergic to with impunity. Rather, it protects them from most accidental exposures. In addition, omalizumab does not cure food allergy and has not demonstrated true immunomodulation. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 8, 2024 Category: Allergy & Immunology Authors: Thomas B. Casale, Alessandro Fiocchi, Matthew Greenhawt Source Type: research

Downregulation of otulin induces inflammasome activation in neutrophilic asthma
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 8, 2024 Category: Allergy & Immunology Authors: Quang Luu Quoc, YeJi Kim, Gunwoo Park, Thi Bich Tra Cao, Youngwoo Choi, Yong Hwan Park, Hae-Sim Park Source Type: research

Preparing Patients for Oral Immunotherapy (PPOINT): International Delphi consensus for procedural preparation and consent
Despite the promise of oral immunotherapy (OIT) to treat food allergies, this procedure is associated with potential risk. There is no current agreement about what elements should be included in the preparatory or consent process. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 8, 2024 Category: Allergy & Immunology Authors: Douglas P. Mack, Timothy E. Dribin, Paul J. Turner, Richard L. Wasserman, Mariam A. Hanna, Marcus Shaker, Mimi L.K. Tang, Pablo Rodr íguez del Río, Brad Sobolewski, Elissa M. Abrams, Aikaterini Anagnostou, Stefania Arasi, Sakina Bajowala, Philippe Bégi Source Type: research

Identification of pyruvic and maleic acid as potential markers for disease activity and prognosis in chronic urticaria
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 8, 2024 Category: Allergy & Immunology Authors: Xingxing Jian, Guixue Hou, Liqiao Li, Zhuo Diao, Yingfang Wu, Jiayi Wang, Lu Xie, Cong Peng, Liang Lin, Jie Li Source Type: research

Addressing Health Disparities and Transitions of Care in EGIDs
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 7, 2024 Category: Allergy & Immunology Authors: Mirna Chehade, Elizabeth T. Jensen, Benjamin L. Wright Source Type: research

Targeting Inhibitory Siglec-3 to Suppress IgE-Mediated Human Basophil Degranulation
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Suzanne M. Barshow, Maidul Islam, Scott Commins, Matthew S. Macauley, James C. Paulson, Michael D. Kulis Source Type: research

On mentoring and being mentored —a lifetime journey and legacy
When Zuhair Ballas and the Journal of Allergy and Clinical Immunology editors asked me to write an editorial on mentoring, I was honored to be included in a series of individuals whom I view as “giants” and role models in the field—Drs Frank Austen,1 Bill Busse,2 Dean Metcalfe,3 and Kate Sullivan4—and the equally important view from the fellow/trainee perspective by Drs Ayobami Akenroye and Corinne Keet.5 My perspective on mentoring and being mentored has literally been lifelong. I was born the daughter of an allergist, my late mother, Dr Chintana Phipatanakul, who became an allergist back in 1972, when I was 3 yea...
Source: Journal of Allergy and Clinical Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Wanda Phipatanakul Tags: Editorial Source Type: research

Immunoglobulin G4-related disease and B-cell malignancy due to an IKZF1 gain-of-function variant
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Blanca Garc ía-Solís, María Tapia-Torres, Ana García-Soidán, Elisa Hernández-Brito, María Teresa Martínez-Saavedra, José M. Lorenzo Salazar, Sonia García-Hernández, Ana Van Den Rym, Karan Mayani Mayani, José Vicente Govantes-Rodríguez, Adrian Source Type: research

On Mentoring and Being Mentored- a Lifetime Journey and Legacy
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Wanda Phipatanakul Source Type: research

Corrigendum
With regard to the article in the April 2022 issue entitled “Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome” (J Allergy Clin Immunol 2022;151:1081-95), author Eleonora Gambineri would like to update her affiliations to read: Department of NEUROFARBA, Section of Children's Health, University of Florence, Florence, Italy; and Centre of Excellence, Division of Pediatric Oncology/Hematology, Meyer Children’s Hospital IRCCS, Florence, Italy. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 1, 2024 Category: Allergy & Immunology Tags: Corrigendum Source Type: research

News beyond our pages
Janus kinase 1 (JAK1) is critical for type 2 cytokine signaling, and gain-of-function JAK1 mutations are associated with multiple chronic allergic disorders. Tamari et al (Cell 2024;187:44-61.e17; https://doi.org/10.1016/j.cell.2023.11.027) examined the tissue-specific immunoregulatory roles of JAK1 signaling. Spontaneous allergic inflammation was observed in the skin, but not the lungs, of mice containing a pathogenic human JAK1 gain-of-function variant. Moreover, the JAK1 gain-of-function variant protected against allergen-induced airway inflammation. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 1, 2024 Category: Allergy & Immunology Tags: News beyond our pages Source Type: research

The Editors ’ Choice
This study by Ruffner et  al (p 1063) examined esophageal biopsy tissue of pediatric (n = 51) and adult (n = 52) subjects with EoE in remission and control subjects (n = 48 pediatric, n = 167 adult) in association with the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). The authors used a traditio nal clinical cutoff ( (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 1, 2024 Category: Allergy & Immunology Tags: The editors ’ choice Source Type: research

Cover 1
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 1, 2024 Category: Allergy & Immunology Source Type: research