The FOXP3 Δ2 isoform supports regulatory T cell development and protects against severe IPEX
Loss of FOXP3fl and retained expression of FOXP3 Δ2 isoforms due to a novel FOXP3 mutation, demonstrates that FOXP3Δ2 can support Treg development and mediate an attenuated IPEX phenotype. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 20, 2019 Category: Allergy & Immunology Authors: Katie Frith, Anne-Laure Joly, Cindy S. Ma, Stuart G. Tangye, Zuzana Lohse, Christina Seitz, Charles F. Verge, John Andersson, Paul Gray Source Type: research

Therapeutic potential of D prostanoid receptor 1 signal enhancement in a murine model of food allergy
Mast cells play a key role in the development of antigen-induced food allergies. Activated mast cells release several inflammatory mediators that induce local intestinal inflammation and lead to systemic allergy symptoms. This intestinal inflammation stimulates infiltration of mucosal mast cells (MMCs) into the intestinal tract, resulting in expansion of intestinal mast cells. Furthermore, patients with food allergies possess greater numbers of intestinal mast cells than those without food allergies. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 19, 2019 Category: Allergy & Immunology Authors: Tatsuro Nakamura, Rina Hirai, Yuri Tachibana, Sakura Masuko, Nanae Nagata, Takahisa Murata Tags: Letter to the Editor Source Type: research

Distribution of subsets of blood monocytic cells throughout life
This study provides a novel and detailed frame of reference of normal counts of different monocytic cell subsets in blood throughout life and highlights their differential distribution among distinct lymphoid tissues. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 16, 2019 Category: Allergy & Immunology Authors: Daniela Damasceno, Cristina Teodosio, Wouter B.L. van den Bossche, Mart ín Perez-Andres, Sonia Arriba-Méndez, Luis Muñoz-Bellvis, Alfonso Romero, Juan F. Blanco, Ana Remesal, Noemi Puig, Sergio Matarraz, José Luis Vicente-Villardón, Jacques J.M. van Source Type: research

Double-blind, randomised, placebo-controlled trial of allergen-specific immunotherapy with major allergen Alt a 1
It is the first phase III clinical trial conducted with only one protein, Alt a 1, for the treatment of allergies. Significant clinical improvement has been achieved after one year of treatment with a high safety profile. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 14, 2019 Category: Allergy & Immunology Authors: Ana Isabel Tabar, Luis Prieto, Pilar Alba, Antonio Nieto, Mercedes Rodr íguez, Miguel Torrecillas, Beatriz Huertas, Elisa Gómez, Francisco Javier Fernández, Miguel Blanca, David Rodríguez, Ricardo Palacios Source Type: research

Amoxicillin sensitization rate in patients with eruptions after Helicobacter pylori eradication therapy
I read with interest the recent article by Ito et  al.1 The authors reported that only 2 of 15 patients with skin eruptions after eradication therapy for Helicobacter pylori using amoxicillin, clarithromycin, and a proton pump inhibitor had positive results on repeated drug lymphocyte transformation tests (LTTs), and in another patient CD4+ T cell s expressed CD154 in response to the drugs. They elegantly demonstrated that a significant proportion of the patients with negative drug-specific responses (9/12) exhibited H pylori–specific immune responses. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 13, 2019 Category: Allergy & Immunology Authors: Kazuhiro Kawai Tags: Correspondence Source Type: research

Reply
We thank Dr Kawai for his comments1 on our study2 on hypersensitivity to Helicobacter pylori induced during eradication therapy that results in skin manifestations. Dr Kawai raised a question about the results of lymphocyte transformation tests (LTTs) for patients with skin eruptions after H pylori eradication therapy. He showed a high frequency of positive LTT results in patients with skin eruptions and suggested that this difference is caused by the timing of the LTTs. At his institution, the LTTs were performed once within 3  days after onset, whereas at our institution, the drug LTTs were performed at least 3 time...
Source: Journal of Allergy and Clinical Immunology - March 13, 2019 Category: Allergy & Immunology Authors: Akito Hasegawa, Riichiro Abe Tags: Correspondence Source Type: research

The very preterm neonate's role in prevention of atopic disease
I read with interest the November 2018 article titled “Cesarean delivery, preterm birth, and risk of food allergy: Nationwide Swedish cohort study of more than 1 million children.”1 This is an excellent start to our full-scope understanding of the variety of perinatal environmental factors that predispose our youngest infants to food allergy. These data bring support to a well-established association between cesarean delivery and increased risk of subsequent diagnosis of food allergy.2 However, I am particularly interested in the data generated in this study demonstrating an inverse association between food all...
Source: Journal of Allergy and Clinical Immunology - March 12, 2019 Category: Allergy & Immunology Authors: Andrew Winslow Tags: Correspondence Source Type: research

Reply
We sincerely appreciate Winslow's comment1 on our article.2 (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 12, 2019 Category: Allergy & Immunology Authors: Niki Mitselou, Erik Mel én, Jonas F. Ludvigsson Tags: Correspondence Source Type: research

Applying the CAMP trial asthma remission prediction model to the Dutch asthma remission studies
A small subset of patients with asthma can go into spontaneous remission later in life.1,2 Predicting this clinical trajectory would be of great interest, because these asthma remission subjects are not burdened by symptoms anymore and no longer require any medication. Wang et  al3 created a prediction model that could predict asthma remission outcome. They showed that the combination of normal FEV1/forced vital capacity (FVC) ratio, less severe bronchial hyperresponsiveness, and blood eosinophil counts of less than 500 cells/μL at age 8 years yields more than 80% pro bability to achieve asthma remission ...
Source: Journal of Allergy and Clinical Immunology - March 12, 2019 Category: Allergy & Immunology Authors: Orestes A. Carpaij, Judith M. Vonk, Martijn C. Nawijn, Huib A.M. Kerstjens, Gerard H. Koppelman, Maarten van den Berge Tags: Correspondence Source Type: research

Reply
In our article on childhood asthma remission from the Childhood Asthma Management Program (CAMP) cohort,1 we identified predictors of both asthma remission and persistence into adulthood. The predicted probability of asthma remission was the highest (82.6%) in subjects with a baseline FEV1 to forced vital capacity (FEV1/FVC) ratio of greater than or equal to 85%, provocative concentration causing a 20% fall in FEV1 (PC20) of greater than or equal to 1  mg/mL, and serum eosinophil count of less than 500 cells/μL. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 12, 2019 Category: Allergy & Immunology Authors: Alberta L. Wang, Kelan G. Tantisira Tags: Correspondence Source Type: research

IL-33trap is a novel IL-33 neutralizing biologic that inhibits allergic airway inflammation
IL-33 is an important therapeutic target in allergic diseases. Here we describe the generation and biological activity of a novel IL-33 antagonist, IL-33trap, which shows anti-inflammatory activities in a preclinical mouse model for acute allergic airway inflammation. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 12, 2019 Category: Allergy & Immunology Authors: Aurora Holgado, Harald Braun, Elien Van Nuffel, Sammy Detry, Martijn J. Schuijs, Kim Deswarte, Karl Vergote, Mira Haegman, Griet Baudelet, Jurgen Haustraete, Hamida Hammad, Bart N. Lambrecht, Savvas N. Savvides, Inna S. Afonina, Rudi Beyaert Source Type: research

Immunodeficiency and Epstein Barr virus induced lymphoproliferation caused by 4-1BB deficiency
We have identified a novel immunodeficiency associated with EBV induced lymphoproliferation due to a homozygous missense mutation in 4-1BB, demonstrating a critical role for 4-1BB in the human immune response against EBV-driven B cell lymphoproliferation. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 11, 2019 Category: Allergy & Immunology Authors: Mohammed Alosaimi, Manfred Hoenig, Faris Jaber, Craig D. Platt, Jennifer Jones, Jacqueline Wallace, Klaus-Michael Debatin, Ansgar Schulz, Eva Jacobsen, Peter M öller, Hanan E. Shamseldin., Ferdous Abdulwahab, Niema Ibrahim, Hosam Alardati, Faisal Almuhiz Source Type: research

Apolipoprotein E is a Concentration-dependent Pulmonary Danger Signal that Activates the NLRP3 Inflammasome and IL-1 β Secretion by Asthmatic Macrophages
Apolipoprotein E is a concentration-dependent danger signal in the lung that can prime and activate the NLRP3 inflammasome in asthmatic macrophages to secrete IL-1 β. This may promote and amplify inflammation when pulmonary APOE concentrations are increased above normal levels. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 11, 2019 Category: Allergy & Immunology Authors: Elizabeth M. Gordon, Xianglan Yao, Haitao Xu, William Karkowsky, Maryann Kaler, Or Kalchiem-Dekel, Amisha V. Barochia, Meixia Gao, Karen J. Keeran, Kenneth R. Jeffries, Stewart J. Levine Source Type: research

Loss of bronchoprotection with ICS+LABA, beta-receptor dynamics, and the effect of alendronate
When used with ICS, regular LABA use does not cause reductions in bronchoprotection in a majority of patients. In those who become more sensitive to bronchoconstrictors, downregulation of beta-receptors may not account for this sensitivity. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 11, 2019 Category: Allergy & Immunology Authors: Juan Carlos Cardet, Xiaofeng Jiang, Quan Lu, Norma Gerard, Kristen McIntire, Homer A. Boushey, Mario Castro, Vernon M. Chinchilli, Christopher D. Codispoti, Anne-Marie Dyer, Fernando Holguin, Monica Kraft, Stephen Lazarus, Robert F. Lemanske, Njira Lugogo Source Type: research

Harmonized Outcome Measures for Use in Asthma Patient Registries and Clinical Practice
A minimum set of patient outcome measures was developed through a consensus-based process for use in asthma research and clinical practice. Measure definitions were mapped to standardized terminologies to support implementation in electronic health records. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 8, 2019 Category: Allergy & Immunology Authors: Richard E. Gliklich, Mario Castro, Michelle B. Leavy, Valerie G. Press, Amisha Barochia, Christopher L. Carroll, Julie Harris, Sarah S. Rittner, Robert Freishtat, Reynold A. Panettieri, Giselle S. Mosnaim Source Type: research

Galectin-3 is Essential for IgE-Dependent Activation of Human Basophils by A549 Lung Epithelial Cells
Using novel co-culture model systems, galectin-3 is shown to facilitate basophil secretion of IL-4/IL-13, with implications that this unique mode of activation may be linked to a variety of diseases ranging from asthma to cancer. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 8, 2019 Category: Allergy & Immunology Authors: John T. Schroeder, Abiodun A. Adeosun, Danh Do, Anja P. Bieneman Source Type: research

Dust mite induces leukocyte exosomes with proinflammatory effects towards airway epithelial cells
Leukocytes from dust-mite- allergic, human donors secrete exosomes in response to house dust mite exposure. Exosomes from dust-mite stimulated PBMCs have proinflammatory effects on airway epithelial cells. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 8, 2019 Category: Allergy & Immunology Authors: Kristin A. Lambert, Man-Hsun Hsu, Zoe C. Laryea, Yuanjun Zhao, Alanna N. Roff, Jeffrey M. Sundstrom, Faoud T. Ishmael Source Type: research

Ezh2 controls development of natural killer T cells that cause spontaneous asthma-like pathology
The epigenetic regulator Ezh2 suppresses development of an IL-4-expressing natural killer T cell population that causes hyper-IgE, airway inflammation and airway hyperreactivity in mice. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 6, 2019 Category: Allergy & Immunology Authors: Damon Tumes, Kiyoshi Hirahara, Magdalene Papadopoulos, Kenta Shinoda, Atsushi Onodera, Jin Kumagai, Kwok Ho Yip, Harshita Pant, Kota Kokubo, Kiuchi Masahiro, Ami Aoki, Kazushige Obata-Ninomiya, Koji Tokoyoda, Yusuke Endo, Motoko Y. Kimura, Toshinori Nakay Source Type: research

Immunologic Mechanisms of Short-course of Lolium Perenne Peptide Immunotherapy: A Randomized Double-Blind Placebo-Controlled Trial
Pre-seasonal short-course of hydrolysates of Lolium perenne peptides (LPP) immunotherapy is clinically effective and accompanied by modulation of T and B cell subsets. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 4, 2019 Category: Allergy & Immunology Authors: Hanisah Sharif, Iesha Singh, Lubna Kouser, Ralph M ösges, Marie-Alix Bonny, Angeliki Karamani, Rebecca V. Parkin, Nicolas Bovy, Uday Kishore, Abigail Robb, Michael Katotomichelakis, Gabriele Holtappels, Lara Derycke, Francis Corazza, Rémy von Frenckell, Source Type: research

Corrigendum
With regard to the article in the December 2018 issue entitled, “Role of human forkhead box P3 in early thymic maturation and peripheral T-cell homeostasis” (J Allergy Clin Immunol 2018;142:1909-21.e9), the authors have notified the Journal that one co-author's funding grant was inadvertently omitted. The funding statement should be amended to read “Suppor t for Laura Passerini was provided from the Italian Ministry of Health GR-2011-02346941.” The authors regret the error. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Tags: Corrigendum Source Type: research

Corrigendum
With regard to the Editorial published in the January 2019 issues of JACI and JACI: In Practice entitled “Indirect treatment comparisons and biologics” (J Allergy Clin Immunol 2019;143:84-6), the authors have notified both Journals that the last terms in the equation in the first column contained an error. The equation should read: TX−Ty = [TX−PX] − [TY−PY] + [PX−PY] rather than TX−Ty = [TX−PX] − [TY−PY] − [TX−PY] as printed. Additionally, a dollar sign was missing from Table I, last column, 3rd line, which should be modified ...
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Tags: Corrigendum Source Type: research

Molecular diagnosis for allergen immunotherapy
The extensive use of allergen molecules in birth cohort studies revealed that atopic sensitization is a sequential IgE response to distinct non –cross-reacting molecules from the same allergenic source (ie, molecular spreading), starting with an initiator molecule. This phenomenon reaches different degrees of progression (monomolecular, oligomolecular, and polymolecular) according to the individual atopic propensity and allergen exposure, thus producing an extreme heterogeneity of IgE sensitization profiles in patient populations. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Authors: Paolo Maria Matricardi, Stephanie Dramburg, Ekaterina Potapova, Chrysanthi Skevaki, Harald Renz Tags: Reviews and feature article Source Type: research

News Beyond Our Pages
Hereditary angioedema (HAE) is characterized by recurrent and unpredictable angioedema attacks and occurs as a result of impairment of C1 esterase inhibitor activity, which leads to dysregulation of plasma kallikrein activity and excessive production of bradykinin. Banerji et al (JAMA 2018;320:2108-2; https://doi.org/10.1001/jama.2018.16773) assessed the efficacy of lanadelumab, an mAb that targets active plasma kallikrein, in the prevention of HAE attacks in a multicenter phase 3 trial. One hundred thirteen patients were randomized to receive one of 3 doses of subcutaneous lanadelumab or placebo over 26 weeks. (Source: Jo...
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Authors: Marc E. Rothenberg, Jean Bousquet Tags: News beyond our pages Source Type: research

Understanding differences in allergen immunotherapy products and practices in North America and Europe
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Tags: Continuing Medical Education examination Source Type: research

Understanding differences in allergen immunotherapy products and practices in North America and Europe
Allergen immunotherapy (AIT) is thought to be clinically effective and safe in treating allergic rhinitis, asthma, and stinging insect allergy in Europe and North America. However, there are intercontinental differences in AIT therapeutic products in terms of their application and regulation. In North America unmodified standardized and nonstandardized aqueous aeroallergen extracts are approved and used almost exclusively for subcutaneous immunotherapy, whereas more product options are available in Europe, including adsorbed allergens, chemically modified allergens, or both. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Authors: Vera Mahler, Robert E. Esch, J örg Kleine-Tebbe, William J. Lavery, Greg Plunkett, Stefan Vieths, David I. Bernstein Tags: Reviews and feature article Source Type: research

The Editors' Choice
Tree pollen allergy is often caused by pollen from the birch tree family, including hazel, alder, birch, and others. Cosensitization to pollen within this family is common, extending the season and geographic area in which allergic symptoms are triggered. In this issue, Biedermann et  al (p 1058) report results of a large phase III clinical trial on a new sublingual immunotherapy tablet containing birch pollen extract (SQ tree SLIT-tablet; ALK-Abelló, Hørsholm, Denmark) for treatment of allergic rhinoconjunctivitis: (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Authors: Zuhair K. Ballas, Associate Editors of the JACI Tags: The Editors' choice Source Type: research

Cover 1
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Source Type: research

Brief Overview of This Month's JACI
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Source Type: research

Table of Contents
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Source Type: research

Editorial Board
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Source Type: research

Information for Readers
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Source Type: research

News & Notes
While the topic of food allergy was heavily featured at the 2019 AAAAI Annual Meeting, you may be looking for an even greater breadth of knowledge on this topic. That ’s why AAAAI President Robert A. Wood, MD, FAAAAI, has designed a new food allergy course taking place September 6-8, 2019, in Chicago, Illinois. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Tags: Reader service Source Type: research

Continuing Medical Education Calendar
The following offer AMA PRA Category 1 Credits ™ and meet the ABAI requirements for MOC: (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Source Type: research

A Special Thank-You to Our Reviewers
The Editors wish to acknowledge the contributions of the following colleagues in the field of allergy and immunology who served as reviewers for JACI during 2018. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Source Type: research

Defects in memory B-cell and plasma cell subsets expressing different immunoglobulin-subclasses in CVID and Ig-subclass deficiencies
Dissection of the blood plasma cell and memory B-cell compartments and their immunoglobulin-subclass expression patterns in predominantly antibody deficiencies, shows unique B-cell defective profiles associated with the diagnostic subtype and clinical manifestations of the disease. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Authors: Elena Blanco, Mart ín Pérez-Andrés, Sonia Arriba-Méndez, Cristina Serrano, Ignacio Criado, Lucía del Pino-Molina, Susana Silva, Ignacio Madruga, Marina Bakardjieva, Catarina Martins, Ana Serra Caetano, Alfonso Romero, Teresa Contreras-Sanfeliciano, C Source Type: research

Impact of weather and climate change with indoor and outdoor air quality in asthma
Weather and climate change are constant and ever-changing processes that impact allergy and asthma. The purpose of this report is to provide information since the last climate change review with focus on asthmatic disease. PubMed and internet searches for topics included climate and weather change, air pollution, particulate, greenhouse gasses, traffic, insect habitat, and mitigation, in addition to references contributed by the individual authors. Changes in patterns of outdoor aeroallergens due to increasing temperatures and amounts of carbon dioxide in the atmosphere are major factors linked to increased duration of pol...
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Authors: Jill A. Poole, Charles S. Barnes, Jeffrey G. Demain, Jonathan A. Bernstein, Mahesh A. Padukudru, William Sheehan, Guillermo Guidos, James Wedner, Rosa Codina, Estelle Levetin, John R. Cohn, Steve Kagen, Jay Portnoy, Andre E. Nel Source Type: research

Impaired control of multiple virus infections in a family with complete IRF9 deficiency
We report a kindred deficient in IRF9. The absence of this factor inactivates the interferon response and provokes a marked susceptibility to infection with both RNA and DNA viruses. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Authors: Mar ía Bravo García-Morato, Ane Calvo Apalategi, Luz Yadira Bravo-Gallego, Alfonso Blázquez Moreno, Miriam Simón-Fuentes, Jenny V. Garmendia, Ana Méndez Echevarría, Teresa del Rosal Rabes, Ángeles Domínguez-Soto, Eduardo López-Granados, Hugh T. R Source Type: research

T cell mitochondrial dysfunction and lymphopenia in DOCK2-deficient patients
This study delineates the mitochondrial defects in DOCK2-deficient T cells contributing to the T cell lymphopenia characteristic of this primary immunodeficiency. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Authors: Mohammed F. Alosaimi, Hiba Shendi, Abdallah Beano, Kelsey Stafstrom, Rabab El Hawary, Safa Meshaal, Nermeen Galal, Sung-Yun Pai, Aisha El-Marsafy, Raif S. Geha, Janet Chou Source Type: research

Mast cells – promotors of health and modulators of disease
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2019 Category: Allergy & Immunology Authors: Marcus Maurer, Martin K öberle, Martin Metz, Tilo Biedermann Source Type: research

Gene expression signatures of circulating human type 1, 2 and 3 innate lymphoid cells
We explored gene expression profile of circulating helper-like innate lymphoid cells (ILC). In addition to identifying novel gene signatures, we discovered abnormal T cell receptor expression in ILC, suggesting a link between these cell types. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 27, 2019 Category: Allergy & Immunology Authors: Shuo Li, Hideaki Morita, Milena Sokolowska, Ge Tan, Tadech Boonpiyathad, Lennart Opitz, Keisuke Orimo, Stuart Archer, Kirstin Jansen, Mimi Tang, Damian Purcell, Magdalena Plebanski, Cezmi A. Akdis Source Type: research

Fevipiprant, a selective prostaglandin-D2 receptor-2 antagonist, inhibits human group-2 innate lymphoid cell aggregation and function
Fevipiprant is a potent inhibitor of PGD2-mediated ILC2 activation. The findings support further development as a therapeutic intervention for asthma. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 27, 2019 Category: Allergy & Immunology Authors: Clare Hardman, Wentao Chen, Jian Luo, Paul Batty, Yi-Ling Chen, Janina Nahler, Yanqiu Wu, Ian D. Pavord, Veit J. Erpenbeck, David A. Sandham, Luzheng Xue, Graham Ogg Source Type: research

The MALT1 locus and Peanut Avoidance in the Risk for Peanut Allergy
We identified a strong association between peanut allergy and the MALT1 locus in LEAP participants in the peanut avoidance group with 58.6% of carriers developing peanut allergy at 60 months as compared to 12.7% of non-carriers. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 27, 2019 Category: Allergy & Immunology Authors: Alexandra Winters, Henry T. Bahnson, Ingo Ruczinski, Meher P. Boorgula, Claire Malley, Ali R. Keramati, Sameer Chavan, David Larson, Karen Cerosaletti, Peter H. Sayre, Marshall Plaut, George Du Toit, Gideon Lack, Kathleen C. Barnes, Gerald T. Nepom, Rasik Source Type: research

F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in humans
FCHO1 deficiency is a novel autosomal recessive combined immune deficiency with impaired clathrin-mediated endocytosis (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 26, 2019 Category: Allergy & Immunology Authors: Enrica Calzoni, Craig D. Platt, Sevgi Keles, Hye Sun Kuehn, Sarah Beaussant-Cohen, Yu Zhang, Julia Pazmandi, Gaetana Lanzi, Francesca Pala, Azzeddine Tahiat, Hasibe Artac, Raul Jimenez Heredia, Jasmin Dmytrus, Ismail Reisli, Vedat Uygun, Dilara Uygun, Ays Source Type: research

Lack of Protein Prenylation Promotes Nlrp3 Inflammasome Assembly in Human Monocytes
We demonstrate that blocking the mevalonate pathway and protein prenylation in human monocytes leads to enhanced activity of an NLRP3-dependent, but not Pyrin-dependent, inflammasome, suggesting a prominent role for NLRP3 in the pathogenesis of mevalonate kinase deficiency. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 21, 2019 Category: Allergy & Immunology Authors: Oliver P. Skinner, Julie Jurczyluk, Paul J. Baker, Seth L. Masters, Alicia Rios Wilks, Misaki S. Clearwater, Avril A.B. Robertson, Kate Schroder, Sam Mehr, Marcia A. Munoz, Michael J. Rogers Source Type: research

Prophylactic allergen immunotherapy with Der p 2 prevents murine asthma by regulating lung GM-CSF
This mouse study demonstrates that repetitive inhalation of a single major house dust mite (HDM) allergen prevents HDM-induced allergic asthma development through suppressing the function of lung dendritic cells, thus providing an alternative to classical allergen-specific immunotherapy. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 20, 2019 Category: Allergy & Immunology Authors: Eline Haspeslagh, Manon Vanheerswynghels, Kim Deswarte, Justine van Moorleghem, Alain Jacquet, Bart N. Lambrecht, Hamida Hammad Source Type: research

Allergen immunotherapy improves defective follicular regulatory T cells in patients with allergic rhinitis
The defect of Tfr cells may contribute to aberrant IgE production in AR patients. The improvement of Tfr cells correlates with the clinical benefits of AIT in AR patients. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 20, 2019 Category: Allergy & Immunology Authors: Yin Yao, Zhi-Chao Wang, Nan Wang, Peng-Cheng Zhou, Cai-Ling Chen, Jia Song, Li Pan, Bo Liao, Xin-Hao Zhang, Yong-Shi Yang, Xiao-Yan Xu, Rong-Fei Zhu, Di Yu, Zheng Liu Source Type: research

Intestinal archaea inversely associated with childhood asthma
Methanosphaera stadtmanae, an immunogenic archaeal species found in the human gut microbiome, was detected less frequently in children with asthma. Gut archaea colonisation in childhood may be relevant to asthma and allergy risk. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 20, 2019 Category: Allergy & Immunology Authors: David J.M. Barnett, Monique Mommers, John Penders, Ilja C.W. Arts, Carel Thijs Source Type: research

B cell-intrinsic requirement for STK4 in humoral immunity in mice and humans
Humoral immune defects are described in 9 patients from 5 families with STK4 deficiency. A mouse model carrying the novel p.Y88del show that these defects are intrinsic to the B cells. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 20, 2019 Category: Allergy & Immunology Authors: Imogen Moran, Danielle T. Avery, Kathryn Payne, Helen Lenthall, E.Graham Davies, Siobhan Burns, Winnie Ip, Mat ÿfffedas M. Oleastro, Ismail Reisli, Sukru Guner, Sevgi Keles, Luigi Notarangelo, Elissa K. Deenick, Christopher C. Goodnow, David Zahra, Rober Source Type: research

Lymphoproliferative Disease in Wiskott-Aldrich Syndrome. Analysis of the French Registry of Primary Immunodeficiencies
Aggressive mature B-cell LPD can occur in WAS as in XLT pediatric and adult patients. Immunochemotherapy is applicable to all WAS/XLT patients, while transplantation still remains controversial for adult patients. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 20, 2019 Category: Allergy & Immunology Authors: Morgane Cheminant, Nizar Mahlaoui, C éline Desconclois, Danielle Canioni, Loïc Ysebaert, Loïc Dupré, Zilton Vasconcelos, Marion Malphettes, Despina Moshous, Bénédicte Neven, Pierre-Simon Rohrlich, Marc Bernard, Yves Bertrand, Alain Fischer, Felipe S Source Type: research

Lymphoproliferative disease in patients with Wiskott-Aldrich syndrome: Analysis of the French Registry of Primary Immunodeficiencies
Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary immune deficiency caused by mutations in the WAS gene. The clinical triad of microthrombocytopenia, eczema, and immunodeficiency defines the classical WAS phenotype, whereas the so-called “attenuated form,” X-linked thrombocytopenia (XLT), manifests with thrombocytopenia alone with or without mild eczema. An increased risk of lymphoproliferative disease (LPD) in patients with WAS/XLT has been described as early as 19611 and confers a poor prognosis to patients. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 20, 2019 Category: Allergy & Immunology Authors: Morgane Cheminant, Nizar Mahlaoui, C éline Desconclois, Danielle Canioni, Loïc Ysebaert, Loïc Dupré, Zilton Vasconcelos, Marion Malphettes, Despina Moshous, Bénédicte Neven, Pierre-Simon Rohrlich, Marc Bernard, Yves Bertrand, Alain Fischer, Felipe S Tags: Letter to the Editor Source Type: research