A Prospective Observational Study of Autoimmune Encephalitis in Northwestern India
CONCLUSION: Autoimmune encephalitis (AIE), a potentially treatable immune-responsive entity, is a common neurological problem and may be an answer to a large number of cases having unexplained encephalitis. Good clinical acumen and knowledge are required for early diagnosis and treatment of this potentially reversible disorder. How to cite this article: Sharma B, Paul M, Bagaria AK. A Prospective Observational Study of Autoimmune Encephalitis in Northwestern India. J Assoc Physicians India 2023;71(9):39-44.PMID:38700300 | DOI:10.59556/japi.71.0312 (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - May 3, 2024 Category: General Medicine Authors: Bhawna Sharma Madhuparna Paul Amit K Bagaria Source Type: research
PD-1/PD-L1 pathway: Current research in breast cancer
CONCLUSIONS: The combination of PD-1/PD-L1 is essential for many malignancies. According to the evidence presented, this combination presents both an opportunity and a challenge in cancer treatment. Since many solid cancers, especially BC, express high levels of PD-1/PD-L1, cancer treatment mainly involves targeted therapies.PMID:38701137 | DOI:10.3233/BD-249006 (Source: Breast Disease)
Source: Breast Disease - May 3, 2024 Category: Cancer & Oncology Authors: Salman Ardi Syamsu Muhammad Faruk Nilam Smaradania Elridho Sampepajung Agung Sindu Pranoto Febie Irsandy Iin Fadhilah Utami Tammasse Source Type: research
Efficacy and safety of transarterial chemoembolization combined with targeted therapy and immunotherapy versus with targeted monotherapy in unresectable hepatocellular carcinoma: A systematic review and meta-analysis
CONCLUSION: Current evidence suggests that, on the basis of TACE combined with targeted therapy, the addition of immunotherapy provides better clinical efficacy and survival benefits for unresectable HCC patients, with good tolerability.PMID:38701263 | DOI:10.1097/MD.0000000000038037 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Jingwen Feng Yi Zhao Lin Zhai Jingxu Zhou Source Type: research
Bone mineral density as an individual prognostic biomarker in NSCLC patients treated with immune checkpoint inhibitors
CONCLUSION: Lower baseline BMD is associated with worse clinical outcomes in NSCLC patients treated with ICIs. As a reliable and easily obtained individual prognostic biomarker, BMD can become a routine detection indicator before immunotherapy.PMID:38698843 | PMC:PMC11063287 | DOI:10.3389/fimmu.2024.1332303 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Jie Lou Bingxin Gong Yi Li Yusheng Guo Lin Li Jing Wang Weiwei Liu Ziang You Hongyong Zhang Feng Pan Bo Liang Lian Yang Guofeng Zhou Source Type: research
A Method for the Production of Recombinant VSVs with Confirmation of Biological Activity
Acta Naturae. 2024 Jan-Mar;16(1):59-66. doi: 10.32607/actanaturae.27314.ABSTRACTThe design of new effective cancer treatment methods is a promising and important research field in translational medicine. Oncolytic viruses can induce immunogenic cell death by activating the body's immune system to recognize tumor cells. This work presents the results for optimizing the production of recombinant vesicular stomatitis viruses (rVSVs). To ensure the assembly of viral particles, we developed the HEK293TN-T7 cell line, which stably expresses DNA-dependent RNA polymerase 7 for viral genome transcription, and obtained helper plasmi...
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: V D Moroz N B Gasanov A D Egorov A S Malogolovkin M O Nagornykh E N Subcheva E S Kolosova A Yu Fizikova R A Ivanov A V Karabelsky Source Type: research
Designing combination therapies for cancer treatment: application of a mathematical framework combining CAR T-cell immunotherapy and targeted radionuclide therapy
DISCUSSION: Mathematical models are crucial tools for optimizing the delivery of cancer combination therapy regimens with application along the lines of achieving cure, maximizing survival or minimizing toxicity.PMID:38698840 | PMC:PMC11063284 | DOI:10.3389/fimmu.2024.1358478 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Vikram Adhikarla Dennis Awuah Enrico Caserta Megan Minnix Maxim Kuznetsov Amrita Krishnan Jefferey Y C Wong John E Shively Xiuli Wang Flavia Pichiorri Russell C Rockne Source Type: research
Contemporary Management of Pediatric Brainstem Tumors
Adv Tech Stand Neurosurg. 2024;49:231-254. doi: 10.1007/978-3-031-42398-7_11.ABSTRACTBrain tumors are the second most common malignancy in childhood. Around 15-20% of pediatric brain tumors occur in the brainstem. The most common type of brainstem tumor are diffuse tumors in the ventral pons, whereas focal tumors tend to arise from the midbrain, medulla, and dorsal pons. Glioma is the most common pathological entity. Contemporary management consists of surgery, radiotherapy, chemotherapy, and other adjuvant treatment. Surgical options range from biopsy to radical excision. Biopsy can be performed for diagnostic and prognos...
Source: Advances and Technical Standards in Neurosurgery - May 3, 2024 Category: Neurosurgery Authors: Sheng-Che Chou Yu-Ning Chen Hsin-Yi Huang Meng-Fai Kuo Tai-Tong Wong Sung-Hsin Kuo Shih-Hung Yang Source Type: research
Navigating the landscape of epitranscriptomics and host immunity [REVIEW]
RNA modifications, also termed epitranscriptomic marks, encompass chemical alterations to individual nucleotides, including processes such as methylation and editing. These marks contribute to a wide range of biological processes, many of which are related to host immune system defense. The functions of immune-related RNA modifications can be categorized into three main groups: regulation of immunogenic RNAs, control of genes involved in innate immune response, and facilitation of adaptive immunity. Here, we provide an overview of recent research findings that elucidate the contributions of RNA modifications to each of the...
Source: Genome Research - May 3, 2024 Category: Genetics & Stem Cells Authors: Huang, E., Frydman, C., Xiao, X. Tags: REVIEW Source Type: research
Reactions and adverse events induced by T-cell engagers as anti-cancer immunotherapies, a comprehensive review.
T-cell engagers (TCE) are cancer immunotherapies that have recently demonstrated meaningful benefit for patients with hematological malignancies and solid tumors. The anticipated widespread use of T cell engagers poses implementation challenges and highlights the need for guidance to anticipate, mitigate, and manage adverse events. By mobilizing T-cells directly at the contact of tumor cells, TCE mount an obligatory and immediate anti-tumor immune response that could result in diverse reactions and adverse events. (Source: European Journal of Cancer)
Source: European Journal of Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Arthur G éraud, Thomas Hueso, Ariane Laparra, Naike Bige, Kaissa Ouali, Cécile Cauquil, Annabelle Stoclin, François-Xavier Danlos, Antoine Hollebecque, Vincent Ribrag, Anas Gazzah, Vincent Goldschmidt, Capucine Baldini, Steve Suzzoni, Rastislav Bahleda Tags: Review Source Type: research
CXCR6-positive circulating mucosal-associated invariant T cells can identify patients with non-small cell lung cancer responding to anti-PD-1 immunotherapy
Mucosal-associated invariant T (MAIT) cells have been reported to regulate tumor immunity. However, the immune characteristics of MAIT cells in non-small cell lung cancer (NSCLC) and their correlation with the... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 3, 2024 Category: Cancer & Oncology Authors: Jingjing Qu, Binggen Wu, Lijun Chen, Zuoshi Wen, Liangjie Fang, Jing Zheng, Qian Shen, Jianfu Heng, Jianya Zhou and Jianying Zhou Tags: Research Source Type: research
Toxicity of immunotherapy combinations with chemotherapy across tumor indications: Current knowledge and practical recommendations
Immunotherapy emerged as an additional therapeutic arm in the arsenal against cancer. This new approach is directed towards the host ’s immune system and tumor microenvironment as opposed to the intratumor target of chemotherapy agents. It had achieved unprecedented prolonged responses in a variety of tumors. Immune checkpoint inhibitors (ICI) were the first agents to get numerous histology agnostic tumor approvals, challenging the concept of “one drug-one tumor”. (Source: Cancer Treatment Reviews)
Source: Cancer Treatment Reviews - May 3, 2024 Category: Cancer & Oncology Authors: Layal Rached, Ariane Laparra, Madona Sakkal, Fran çois-Xavier Danlos, Fabrice Barlesi, Franck Carbonnel, Eleonora De Martin, Michel Ducreux, Caroline Even, Jerome Le Pavec, Jean-Marie Michot, Joana MRibeiro, Florian Scotte, Santiago Ponce Aix, Olivier La Source Type: research
Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma
There are no effective approaches to overcome the immunosuppressive activity of tumor-associated macrophages (TAMs). De Leo et al. report that monocyte-derived macrophages (MDMs), but not microglia (MGs), are major contributors to the immunosuppression associated with TAMs in glioblastoma and demonstrate that PERK-perturbed glucose metabolism drives MDM immunosuppressive programs via histone lactylation. Targeting of PERK -driven histone lactylation boosts the effect of immunotherapy. (Source: Immunity)
Source: Immunity - May 3, 2024 Category: Allergy & Immunology Authors: Alessandra De Leo, Alessio Ugolini, Xiaoqing Yu, Fabio Scirocchi, Delia Scocozza, Barbara Peixoto, Angelica Pace, Luca D ’Angelo, James K.C. Liu, Arnold B. Etame, Aurelia Rughetti, Marianna Nuti, Antonio Santoro, Michael A. Vogelbaum, Jose R. Conejo-Gar Tags: Article Source Type: research
Multi-omic profiling reveals potential biomarkers of hepatocellular carcinoma prognosis and therapy response among mitochondria-associated cell death genes in the context of 3P medicine
ConclusionThis study developed a novel predictive model for LIHC, namely MCDI. Incorporating MCDI into the PPPM framework will enhance clinical decision-making processes and optimize individualized treatment strategies for LIHC patients.Graphical Abstract (Source: EPMA Journal)
Source: EPMA Journal - May 3, 2024 Category: International Medicine & Public Health Source Type: research
Application of Genomic Medicine in Africa: 14th Conference of the African Society of Human Genetics and the 2nd International Congress of the Moroccan Society of Genomics and Human Genetics, Rabat, Morocco 2022
Am J Trop Med Hyg. 2024 May 2:tpmd230808. doi: 10.4269/ajtmh.23-0808. Online ahead of print.ABSTRACTThe 14th African Society of Human Genetics (AfSHG) Morocco Meeting and 2nd International Congress of the Moroccan Society of Genomics and Human Genetics (SM2GH), held in Rabat, Morocco, from December 12 through 17, 2022, brought together 298 attendees from 23 countries, organized by the AfSHG in collaboration with the SM2GH. The conference's overarching theme was "Applications of Genomics Medicine in Africa," covering a wide range of topics, including population genetics, genetics of infectious diseases, hereditary disorders...
Source: The American Journal of Tropical Medicine and Hygiene - May 2, 2024 Category: Tropical Medicine Authors: Meryem Fakhkhari Ikram Salih Najwa Maazaz Victoria Nembaware Nchangwi Syntia Munung Alice Matimba Sanaa Chala Ahmed Belmouden Karon Chappell Leon Mutesa Ghada El-Kamah Hicham Oumzil Larbi Baassi Younes Abbas Mohamed Zahir Alimohamed Michele Ramsay Scott W Source Type: research
Extracellular Vesicles-powered Immunotherapy: Unleashing the Potential for Safer and More Effective Cancer Treatment
This article discusses the importance of integrating nanomedicines into OIMTs, highlighting the challenges with current anti-OIMT methods. It also explores key considerations for designing nanomedicines tailored for OIMTs, aiming to improve upon existing immunotherapy techniques. Additionally, the article looks into innovative approaches like biomimicry and the use of natural biomaterial-based nanocarriers (NCs). These advancements have the potential to transform the delivery of immunotherapy. Lastly, the article addresses the challenges of moving OIMTs from theory to clinical practice, providing insights into the future o...
Source: Archives of Biochemistry and Biophysics - May 2, 2024 Category: Biochemistry Authors: Pratiksha Tiwari Krishna Yadav Ravi Prakash Shukla Avijit Kumar Bakshi Dilip Panwar Sweety Das Prabhat Ranjan Mishra Source Type: research
